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Conserved domains on  [gi|56790319|ref|NP_694516|]
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one cut domain, family member, like [Danio rerio]

Protein Classification

CUT homeobox family transcription factor( domain architecture ID 10493120)

CUT homeobox family transcription factor regulates gene networks by controlling the expression of other transcription factors and plays an important role in cell differentiation and metabolism

Gene Ontology:  GO:0003700|GO:0030154

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 264-338 1.65e-39

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


:

Pssm-ID: 460543  Cd Length: 78  Bit Score: 136.57  E-value: 1.65e-39
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56790319   264 GEEINTKDVAQRIITELKRYSIPQAIFAERVLCRSQGTLSDLLRNPKPWGKLKSGRETFKRMSRWLQEPEFQRMA 338
Cdd:pfam02376   2 SEELDTKDIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLRKPKPWEKLKSGGRTFIRMYNWLSLPEDERME 76
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 361-415 7.31e-12

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 60.34  E-value: 7.31e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 56790319    361 PKRTRLVFTDLQRRTLMAIFRENHRPTKDLQITISQQLGLELSTVSNFFMNARRR 415
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
 
Name Accession Description Interval E-value
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 264-338 1.65e-39

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


Pssm-ID: 460543  Cd Length: 78  Bit Score: 136.57  E-value: 1.65e-39
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56790319   264 GEEINTKDVAQRIITELKRYSIPQAIFAERVLCRSQGTLSDLLRNPKPWGKLKSGRETFKRMSRWLQEPEFQRMA 338
Cdd:pfam02376   2 SEELDTKDIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLRKPKPWEKLKSGGRTFIRMYNWLSLPEDERME 76
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 361-415 7.31e-12

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 60.34  E-value: 7.31e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 56790319    361 PKRTRLVFTDLQRRTLMAIFRENHRPTKDLQITISQQLGLELSTVSNFFMNARRR 415
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 362-415 6.70e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 57.64  E-value: 6.70e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 56790319 362 KRTRLVFTDLQRRTLMAIFRENHRPTKDLQITISQQLGLELSTVSNFFMNARRR 415
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAK 54
Homeodomain pfam00046
Homeodomain;
362-415 6.46e-09

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 51.73  E-value: 6.46e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 56790319   362 KRTRLVFTDLQRRTLMAIFRENHRPTKDLQITISQQLGLELSTVSNFFMNARRR 415
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAK 54
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
353-416 4.86e-04

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 40.50  E-value: 4.86e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56790319 353 SKVERNQG----PKRTRLVFTDLQRRTLMAIFRENHRPTKDLQITISQQLGLELSTVSNFFMNARRRN 416
Cdd:COG5576  39 MKLERKQDgsspPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKE 106
 
Name Accession Description Interval E-value
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 264-338 1.65e-39

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


Pssm-ID: 460543  Cd Length: 78  Bit Score: 136.57  E-value: 1.65e-39
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56790319   264 GEEINTKDVAQRIITELKRYSIPQAIFAERVLCRSQGTLSDLLRNPKPWGKLKSGRETFKRMSRWLQEPEFQRMA 338
Cdd:pfam02376   2 SEELDTKDIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLRKPKPWEKLKSGGRTFIRMYNWLSLPEDERME 76
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 361-415 7.31e-12

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 60.34  E-value: 7.31e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 56790319    361 PKRTRLVFTDLQRRTLMAIFRENHRPTKDLQITISQQLGLELSTVSNFFMNARRR 415
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 362-415 6.70e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 57.64  E-value: 6.70e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 56790319 362 KRTRLVFTDLQRRTLMAIFRENHRPTKDLQITISQQLGLELSTVSNFFMNARRR 415
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAK 54
Homeodomain pfam00046
Homeodomain;
362-415 6.46e-09

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 51.73  E-value: 6.46e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 56790319   362 KRTRLVFTDLQRRTLMAIFRENHRPTKDLQITISQQLGLELSTVSNFFMNARRR 415
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAK 54
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
353-416 4.86e-04

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 40.50  E-value: 4.86e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56790319 353 SKVERNQG----PKRTRLVFTDLQRRTLMAIFRENHRPTKDLQITISQQLGLELSTVSNFFMNARRRN 416
Cdd:COG5576  39 MKLERKQDgsspPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKE 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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