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Conserved domains on  [gi|23397464|ref|NP_694944|]
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gap junction beta-4 protein [Homo sapiens]

Protein Classification

gap junction protein( domain architecture ID 11981343)

gap junction protein form gap-junctions between cells and contains four transmembrane (TM) regions; one gap junction consists of a cluster of closely packed pairs of TM channels, the connexons, through which materials of low molecular weight diffuse from one cell to a neighboring cell

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Connexin pfam00029
Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane ...
 2-210 2.36e-123

Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.


:

Pssm-ID: 459638 [Multi-domain]  Cd Length: 217  Bit Score: 349.88  E-value: 2.36e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397464     2 NWAFLQGLLSGVNKYSTVLSRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFVCNTKQPGCPNVCYDEFFPVSHVRLWALQL 81
Cdd:pfam00029   1 DWSFLGRLLEEVNKHSTVVGKIWLTVLFIFRILVLGVAAESVWGDEQSDFVCNTLQPGCENVCYDAFFPISHIRFWVLQI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397464    82 ILVTCPSLLVVMHVAYREERERKH-HLKHGPNAPSLYDNLSKK--------RGGLWWTYLLSLIFKAAVDAGFLYIFHRL 152
Cdd:pfam00029  81 IFVSTPSLLYLGHVAHRIAREEKRrEKEEEEMEEELYEEEGKKeaepkvhiRGGLLWTYVLSLLFRIVLEVGFLVGQYYL 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 23397464   153 YKdYDMPRVVACSVEPCPHTVDCYISRPTEKKVFTYFMVTTAAICILLNLSEVFYLVG 210
Cdd:pfam00029 161 YG-FEVPPLFKCSRSPCPNTVDCFVSRPTEKTIFLLFMFVVSGLCLLLNLLELFYLGW 217
 
Name Accession Description Interval E-value
Connexin pfam00029
Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane ...
 2-210 2.36e-123

Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.


Pssm-ID: 459638 [Multi-domain]  Cd Length: 217  Bit Score: 349.88  E-value: 2.36e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397464     2 NWAFLQGLLSGVNKYSTVLSRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFVCNTKQPGCPNVCYDEFFPVSHVRLWALQL 81
Cdd:pfam00029   1 DWSFLGRLLEEVNKHSTVVGKIWLTVLFIFRILVLGVAAESVWGDEQSDFVCNTLQPGCENVCYDAFFPISHIRFWVLQI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397464    82 ILVTCPSLLVVMHVAYREERERKH-HLKHGPNAPSLYDNLSKK--------RGGLWWTYLLSLIFKAAVDAGFLYIFHRL 152
Cdd:pfam00029  81 IFVSTPSLLYLGHVAHRIAREEKRrEKEEEEMEEELYEEEGKKeaepkvhiRGGLLWTYVLSLLFRIVLEVGFLVGQYYL 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 23397464   153 YKdYDMPRVVACSVEPCPHTVDCYISRPTEKKVFTYFMVTTAAICILLNLSEVFYLVG 210
Cdd:pfam00029 161 YG-FEVPPLFKCSRSPCPNTVDCFVSRPTEKTIFLLFMFVVSGLCLLLNLLELFYLGW 217
Connexin_CCC smart01089
Gap junction channel protein cysteine-rich domain;
141-208 1.84e-33

Gap junction channel protein cysteine-rich domain;


Pssm-ID: 198157  Cd Length: 67  Bit Score: 116.05  E-value: 1.84e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23397464    141 VDAGFLYIFHRLYKdYDMPRVVACSVEPCPHTVDCYISRPTEKKVFTYFMVTTAAICILLNLSEVFYL 208
Cdd:smart01089   1 LEVGFLYGQYYLYG-FQVPPLYKCSRSPCPNTVDCFVSRPTEKTIFLIFMLVVSAICILLNLLELFYL 67
 
Name Accession Description Interval E-value
Connexin pfam00029
Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane ...
 2-210 2.36e-123

Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.


Pssm-ID: 459638 [Multi-domain]  Cd Length: 217  Bit Score: 349.88  E-value: 2.36e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397464     2 NWAFLQGLLSGVNKYSTVLSRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFVCNTKQPGCPNVCYDEFFPVSHVRLWALQL 81
Cdd:pfam00029   1 DWSFLGRLLEEVNKHSTVVGKIWLTVLFIFRILVLGVAAESVWGDEQSDFVCNTLQPGCENVCYDAFFPISHIRFWVLQI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397464    82 ILVTCPSLLVVMHVAYREERERKH-HLKHGPNAPSLYDNLSKK--------RGGLWWTYLLSLIFKAAVDAGFLYIFHRL 152
Cdd:pfam00029  81 IFVSTPSLLYLGHVAHRIAREEKRrEKEEEEMEEELYEEEGKKeaepkvhiRGGLLWTYVLSLLFRIVLEVGFLVGQYYL 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 23397464   153 YKdYDMPRVVACSVEPCPHTVDCYISRPTEKKVFTYFMVTTAAICILLNLSEVFYLVG 210
Cdd:pfam00029 161 YG-FEVPPLFKCSRSPCPNTVDCFVSRPTEKTIFLLFMFVVSGLCLLLNLLELFYLGW 217
Connexin_CCC smart01089
Gap junction channel protein cysteine-rich domain;
141-208 1.84e-33

Gap junction channel protein cysteine-rich domain;


Pssm-ID: 198157  Cd Length: 67  Bit Score: 116.05  E-value: 1.84e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23397464    141 VDAGFLYIFHRLYKdYDMPRVVACSVEPCPHTVDCYISRPTEKKVFTYFMVTTAAICILLNLSEVFYL 208
Cdd:smart01089   1 LEVGFLYGQYYLYG-FQVPPLYKCSRSPCPNTVDCFVSRPTEKTIFLIFMLVVSAICILLNLLELFYL 67
CNX smart00037
Connexin homologues; Connexin channels participate in the regulation of signaling between ...
 42-75 1.29e-21

Connexin homologues; Connexin channels participate in the regulation of signaling between developing and differentiated cell types.


Pssm-ID: 128352  Cd Length: 34  Bit Score: 84.42  E-value: 1.29e-21
                           10        20        30
                   ....*....|....*....|....*....|....
gi 23397464     42 EVWDDEQKDFVCNTKQPGCPNVCYDEFFPVSHVR 75
Cdd:smart00037   1 SVWGDEQSDFVCNTQQPGCENVCYDQAFPISHVR 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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