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Conserved domains on  [gi|23463326|ref|NP_694948|]
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POU domain, class 5, transcription factor 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
121-192 2.01e-37

Pou domain - N-terminal to homeobox domain;


:

Pssm-ID: 459692  Cd Length: 72  Bit Score: 128.16  E-value: 2.01e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23463326   121 GILKELQQLAKELRQKRLSLGYSQADVGIAVGALFGKVLSQTTICRFEAQQLSVANMWKLRPLLKKWLKEVE 192
Cdd:pfam00157   1 LNLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain super family cl47488
Homeodomain;
225-261 5.99e-10

Homeodomain;


The actual alignment was detected with superfamily member pfam00046:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 54.43  E-value: 5.99e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 23463326   225 LEKFFQRCPKPTPQQISHIAGCLQLQKDVVRVWFYNR 261
Cdd:pfam00046  15 LEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNR 51
 
Name Accession Description Interval E-value
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
121-192 2.01e-37

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 128.16  E-value: 2.01e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23463326   121 GILKELQQLAKELRQKRLSLGYSQADVGIAVGALFGKVLSQTTICRFEAQQLSVANMWKLRPLLKKWLKEVE 192
Cdd:pfam00157   1 LNLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
POU smart00352
Found in Pit-Oct-Unc transcription factors;
118-192 2.22e-33

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 117.92  E-value: 2.22e-33
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23463326    118 DISGILKELQQLAKELRQKRLSLGYSQADVGIAVGALFGKVLSQTTICRFEAQQLSVANMWKLRPLLKKWLKEVE 192
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Homeodomain pfam00046
Homeodomain;
225-261 5.99e-10

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 54.43  E-value: 5.99e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 23463326   225 LEKFFQRCPKPTPQQISHIAGCLQLQKDVVRVWFYNR 261
Cdd:pfam00046  15 LEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNR 51
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 225-261 1.01e-08

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 50.71  E-value: 1.01e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 23463326    225 LEKFFQRCPKPTPQQISHIAGCLQLQKDVVRVWFYNR 261
Cdd:smart00389  16 LEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNR 52
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 225-261 3.07e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 49.55  E-value: 3.07e-08
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 23463326 225 LEKFFQRCPKPTPQQISHIAGCLQLQKDVVRVWFYNR 261
Cdd:cd00086  15 LEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNR 51
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 123-199 1.50e-03

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 37.31  E-value: 1.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23463326 123 LKELQQLAKELRQKRLSLGYSQADVGIAVGalfgkvLSQTTICRFEA--QQLSVANMWKLRPLLKKWLKEV---EAENLL 197
Cdd:COG3620  12 VSPDDTLGEALRLMRKELGLSQLPVAELVG------VSQSDILRIESgkRDPTVSTLEKIAEALGKELSAVlvvDDGKLV 85


                ..
gi 23463326 198 GL 199
Cdd:COG3620  86 GI 87
 
Name Accession Description Interval E-value
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
121-192 2.01e-37

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 128.16  E-value: 2.01e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23463326   121 GILKELQQLAKELRQKRLSLGYSQADVGIAVGALFGKVLSQTTICRFEAQQLSVANMWKLRPLLKKWLKEVE 192
Cdd:pfam00157   1 LNLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
POU smart00352
Found in Pit-Oct-Unc transcription factors;
118-192 2.22e-33

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 117.92  E-value: 2.22e-33
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23463326    118 DISGILKELQQLAKELRQKRLSLGYSQADVGIAVGALFGKVLSQTTICRFEAQQLSVANMWKLRPLLKKWLKEVE 192
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Homeodomain pfam00046
Homeodomain;
225-261 5.99e-10

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 54.43  E-value: 5.99e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 23463326   225 LEKFFQRCPKPTPQQISHIAGCLQLQKDVVRVWFYNR 261
Cdd:pfam00046  15 LEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNR 51
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 225-261 1.01e-08

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 50.71  E-value: 1.01e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 23463326    225 LEKFFQRCPKPTPQQISHIAGCLQLQKDVVRVWFYNR 261
Cdd:smart00389  16 LEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNR 52
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 225-261 3.07e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 49.55  E-value: 3.07e-08
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 23463326 225 LEKFFQRCPKPTPQQISHIAGCLQLQKDVVRVWFYNR 261
Cdd:cd00086  15 LEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNR 51
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 123-199 1.50e-03

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 37.31  E-value: 1.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23463326 123 LKELQQLAKELRQKRLSLGYSQADVGIAVGalfgkvLSQTTICRFEA--QQLSVANMWKLRPLLKKWLKEV---EAENLL 197
Cdd:COG3620  12 VSPDDTLGEALRLMRKELGLSQLPVAELVG------VSQSDILRIESgkRDPTVSTLEKIAEALGKELSAVlvvDDGKLV 85


                ..
gi 23463326 198 GL 199
Cdd:COG3620  86 GI 87
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
124-180 3.47e-03

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 36.13  E-value: 3.47e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 23463326 124 KELQQLAKELRQKRLSLGYSQADVGIAVGalfgkvLSQTTICRFEAQQ--LSVANMWKL 180
Cdd:COG1396   3 TLKKALGERLRELRKARGLTQEELAERLG------VSRSTISRIERGRrnPSLETLLKL 55
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
127-180 4.86e-03

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 35.21  E-value: 4.86e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23463326 127 QQLAKELRQKRLSLGYSQADVGIAVGalfgkvLSQTTICRFEA--QQLSVANMWKL 180
Cdd:COG1476   3 KKLGNRLKELRKERGLTQEELAELLG------VSRQTISAIENgkYNPSLELALKI 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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