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Conserved domains on  [gi|1435243651|ref|NP_703151|]
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mediator of RNA polymerase II transcription subunit 19 isoform 2 [Homo sapiens]

Protein Classification

mediator of RNA polymerase II transcription subunit 19 family protein( domain architecture ID 10563233)

mediator of RNA polymerase II transcription subunit 19 (Med19) is a component of the mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med19 pfam10278
Mediator of RNA pol II transcription subunit 19; Med19 represents a family of conserved ...
 63-194 8.50e-72

Mediator of RNA pol II transcription subunit 19; Med19 represents a family of conserved proteins which are members of the multi-protein co-activator Mediator complex. Mediator is required for activation of RNA polymerase II transcription by DNA binding transactivators.


:

Pssm-ID: 287279  Cd Length: 178  Bit Score: 215.08  E-value: 8.50e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435243651  63 GPFYLMRELPGSTELTGSTNLITHYNLEQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILSSSFN 142
Cdd:pfam10278   1 GPFYLLKELPGYSELTGSTNLLTHYGLEHSYSKFCGKKVKEKLSSFLPHLPGMIDLPGTPENSSLRSLIEKPPIGGKELL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1435243651 143 PITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPGKPS 194
Cdd:pfam10278  81 PLTSVQLAGFRLHPGPLPEQYRHMHIQPPTKKHKNKHKKHRTQDPYSEETPL 132
 
Name Accession Description Interval E-value
Med19 pfam10278
Mediator of RNA pol II transcription subunit 19; Med19 represents a family of conserved ...
 63-194 8.50e-72

Mediator of RNA pol II transcription subunit 19; Med19 represents a family of conserved proteins which are members of the multi-protein co-activator Mediator complex. Mediator is required for activation of RNA polymerase II transcription by DNA binding transactivators.


Pssm-ID: 287279  Cd Length: 178  Bit Score: 215.08  E-value: 8.50e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435243651  63 GPFYLMRELPGSTELTGSTNLITHYNLEQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILSSSFN 142
Cdd:pfam10278   1 GPFYLLKELPGYSELTGSTNLLTHYGLEHSYSKFCGKKVKEKLSSFLPHLPGMIDLPGTPENSSLRSLIEKPPIGGKELL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1435243651 143 PITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPGKPS 194
Cdd:pfam10278  81 PLTSVQLAGFRLHPGPLPEQYRHMHIQPPTKKHKNKHKKHRTQDPYSEETPL 132
 
Name Accession Description Interval E-value
Med19 pfam10278
Mediator of RNA pol II transcription subunit 19; Med19 represents a family of conserved ...
 63-194 8.50e-72

Mediator of RNA pol II transcription subunit 19; Med19 represents a family of conserved proteins which are members of the multi-protein co-activator Mediator complex. Mediator is required for activation of RNA polymerase II transcription by DNA binding transactivators.


Pssm-ID: 287279  Cd Length: 178  Bit Score: 215.08  E-value: 8.50e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435243651  63 GPFYLMRELPGSTELTGSTNLITHYNLEQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILSSSFN 142
Cdd:pfam10278   1 GPFYLLKELPGYSELTGSTNLLTHYGLEHSYSKFCGKKVKEKLSSFLPHLPGMIDLPGTPENSSLRSLIEKPPIGGKELL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1435243651 143 PITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPGKPS 194
Cdd:pfam10278  81 PLTSVQLAGFRLHPGPLPEQYRHMHIQPPTKKHKNKHKKHRTQDPYSEETPL 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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