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Conserved domains on  [gi|28572022|ref|NP_733312|]
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Autophagy-related 16, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
143-438 3.43e-56

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.28  E-value: 3.43e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 143 LGQANPTKILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWDIGknSTEPRAVLSGSSAGINSVDFDSTGAYILGTS 222
Cdd:COG2319 104 LWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAVTSVAFSPDGKLLASGS 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 223 NDYGARVWTVMDNRLRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRTLKIWDLRSIACIET-KFAGSSCNDLV-TTDslGS 300
Cdd:COG2319 182 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTlTGHSGSVRSVAfSPD--GR 259

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 301 TIISGHYDKKIRFWDIRTEKQADDVLMP-AKITSLDLSKDCNYLICSVRDDTIKLLDLRKNQVISTFTNEHFKISCdfar 379
Cdd:COG2319 260 LLASGSADGTVRLWDLATGELLRTLTGHsGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---- 335

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 380 ASFNSSGLKIACGSADGAIYIWNVNGFLE-ATLKGHSTAVNAVSWSPNNNMLASVGKNKR 438
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELlRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395
Atg16_CCD super family cl46300
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
 16-41 6.60e-08

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


The actual alignment was detected with superfamily member cd22887:

Pssm-ID: 480640 [Multi-domain]  Cd Length: 91  Bit Score: 49.87  E-value: 6.60e-08
                        10        20
                ....*....|....*....|....*.
gi 28572022  16 QDENRRLLERLMQYKSKDADKLNEEN 41
Cdd:cd22887  66 QEENDELVERWMAKKQQEADKMNEAN 91
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
143-438 3.43e-56

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.28  E-value: 3.43e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 143 LGQANPTKILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWDIGknSTEPRAVLSGSSAGINSVDFDSTGAYILGTS 222
Cdd:COG2319 104 LWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAVTSVAFSPDGKLLASGS 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 223 NDYGARVWTVMDNRLRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRTLKIWDLRSIACIET-KFAGSSCNDLV-TTDslGS 300
Cdd:COG2319 182 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTlTGHSGSVRSVAfSPD--GR 259

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 301 TIISGHYDKKIRFWDIRTEKQADDVLMP-AKITSLDLSKDCNYLICSVRDDTIKLLDLRKNQVISTFTNEHFKISCdfar 379
Cdd:COG2319 260 LLASGSADGTVRLWDLATGELLRTLTGHsGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---- 335

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 380 ASFNSSGLKIACGSADGAIYIWNVNGFLE-ATLKGHSTAVNAVSWSPNNNMLASVGKNKR 438
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELlRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 155-438 7.01e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 168.28  E-value: 7.01e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 155 FEAHENESHAVRWSPVERMVATGGADRKVKLWDIgkNSTEPRAVLSGSSAGINSVDFDSTGAYILGTSNDYGARVWTVMD 234
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 235 NRLRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRTLKIWDLRSIACIetkFAGSSCNDLVTT---DSLGSTIISGHYDKKI 311
Cdd:cd00200  83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL---TTLRGHTDWVNSvafSPDGTFVASSSQDGTI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 312 RFWDIRTEK-QADDVLMPAKITSLDLSKDCNYLICSVRDDTIKLLDLRKNQVISTFT-NEHFKISCdfaraSFNSSGLKI 389
Cdd:cd00200 160 KLWDLRTGKcVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSV-----AFSPDGYLL 234

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 28572022 390 ACGSADGAIYIWNVNGFLE-ATLKGHSTAVNAVSWSPNNNMLASVGKNKR 438
Cdd:cd00200 235 ASGSEDGTIRVWDLRTGECvQTLSGHTNSVTSLAWSPDGKRLASGSADGT 284
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 173-357 1.23e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.40  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022  173 MVATGGADRKVKLWDI------GKNSTEPRAVLSGSSAgINSVDFDSTGAYILGTSNDYGA-RVWTVMDNRLRHTLTGHS 245
Cdd:PLN00181 497 FFATAGVNKKIKIFECesiikdGRDIHYPVVELASRSK-LSGICWNSYIKSQVASSNFEGVvQVWDVARSQLVTEMKEHE 575

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022  246 GKVMAAKYVQ-EPIKVVTGSHDRTLKIWDLR---SIACIETKfaGSSCNDLVTTDSlGSTIISGHYDKKIRFWDIRTEKQ 321
Cdd:PLN00181 576 KRVWSIDYSSaDPTLLASGSDDGSVKLWSINqgvSIGTIKTK--ANICCVQFPSES-GRSLAFGSADHKVYYYDLRNPKL 652

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 28572022  322 ADDVLMP-AKITSLDLSKDCNYLICSVRDDTIKLLDL 357
Cdd:PLN00181 653 PLCTMIGhSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
 16-41 6.60e-08

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 49.87  E-value: 6.60e-08
                        10        20
                ....*....|....*....|....*.
gi 28572022  16 QDENRRLLERLMQYKSKDADKLNEEN 41
Cdd:cd22887  66 QEENDELVERWMAKKQQEADKMNEAN 91
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 150-187 2.26e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.26e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 28572022    150 KILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWD 187
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
150-187 2.37e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.37e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 28572022   150 KILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWD 187
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 16-38 5.90e-05

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 43.38  E-value: 5.90e-05
                          10        20
                  ....*....|....*....|...
gi 28572022    16 QDENRRLLERLMQYKSKDADKLN 38
Cdd:pfam08614 154 EKENRELVERWMKRKGQEAEAMN 176
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
143-438 3.43e-56

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.28  E-value: 3.43e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 143 LGQANPTKILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWDIGknSTEPRAVLSGSSAGINSVDFDSTGAYILGTS 222
Cdd:COG2319 104 LWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAVTSVAFSPDGKLLASGS 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 223 NDYGARVWTVMDNRLRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRTLKIWDLRSIACIET-KFAGSSCNDLV-TTDslGS 300
Cdd:COG2319 182 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTlTGHSGSVRSVAfSPD--GR 259

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 301 TIISGHYDKKIRFWDIRTEKQADDVLMP-AKITSLDLSKDCNYLICSVRDDTIKLLDLRKNQVISTFTNEHFKISCdfar 379
Cdd:COG2319 260 LLASGSADGTVRLWDLATGELLRTLTGHsGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---- 335

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 380 ASFNSSGLKIACGSADGAIYIWNVNGFLE-ATLKGHSTAVNAVSWSPNNNMLASVGKNKR 438
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELlRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395
WD40 COG2319
WD40 repeat [General function prediction only];
91-438 4.12e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.40  E-value: 4.12e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022  91 LIGDEDFDEAAINGAMEAIGLDDNEYISARFTAGEIAENSRASIDTLKATGYLGQANPTKILMKFEAHENESHAVRWSPV 170
Cdd:COG2319  10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 171 ERMVATGGADRKVKLWDIgkNSTEPRAVLSGSSAGINSVDFDSTGAYILGTSNDYGARVWTVMDNRLRHTLTGHSGKVMA 250
Cdd:COG2319  90 GRLLASASADGTVRLWDL--ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 251 A------KYvqepikVVTGSHDRTLKIWDLRSIACIETkFAGSScnDLVTtdSL-----GSTIISGHYDKKIRFWDIRTE 319
Cdd:COG2319 168 VafspdgKL------LASGSDDGTVRLWDLATGKLLRT-LTGHT--GAVR--SVafspdGKLLASGSADGTVRLWDLATG 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 320 KQAdDVLM--PAKITSLDLSKDCNYLICSVRDDTIKLLDLRKNQVISTFTNEHFKISCdfarASFNSSGLKIACGSADGA 397
Cdd:COG2319 237 KLL-RTLTghSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNS----VAFSPDGKLLASGSDDGT 311

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 28572022 398 IYIWNVN-GFLEATLKGHSTAVNAVSWSPNNNMLASVGKNKR 438
Cdd:COG2319 312 VRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 155-438 7.01e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 168.28  E-value: 7.01e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 155 FEAHENESHAVRWSPVERMVATGGADRKVKLWDIgkNSTEPRAVLSGSSAGINSVDFDSTGAYILGTSNDYGARVWTVMD 234
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 235 NRLRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRTLKIWDLRSIACIetkFAGSSCNDLVTT---DSLGSTIISGHYDKKI 311
Cdd:cd00200  83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL---TTLRGHTDWVNSvafSPDGTFVASSSQDGTI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 312 RFWDIRTEK-QADDVLMPAKITSLDLSKDCNYLICSVRDDTIKLLDLRKNQVISTFT-NEHFKISCdfaraSFNSSGLKI 389
Cdd:cd00200 160 KLWDLRTGKcVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSV-----AFSPDGYLL 234

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 28572022 390 ACGSADGAIYIWNVNGFLE-ATLKGHSTAVNAVSWSPNNNMLASVGKNKR 438
Cdd:cd00200 235 ASGSEDGTIRVWDLRTGECvQTLSGHTNSVTSLAWSPDGKRLASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
130-443 2.27e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.69  E-value: 2.27e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 130 SRASIDTLKATGYLGQANPTKILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWDIGknSTEPRAVLSGSSAGINSV 209
Cdd:COG2319   7 AALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAA--AGALLATLLGHTAAVLSV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 210 DFDSTGAYILGTSNDYGARVWTVMDNRLRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRTLKIWDLRSIACIETKFAGSSC 289
Cdd:COG2319  85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 290 NDLVTTDSLGSTIISGHYDKKIRFWDIRTEKQADDVL-MPAKITSLDLSKDCNYLICSVRDDTIKLLDLRKNQVISTFTN 368
Cdd:COG2319 165 VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG 244

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28572022 369 EHFKISCdfarASFNSSGLKIACGSADGAIYIWNVN-GFLEATLKGHSTAVNAVSWSPNNNMLASVGKNKRCTIYS 443
Cdd:COG2319 245 HSGSVRS----VAFSPDGRLLASGSADGTVRLWDLAtGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316
WD40 COG2319
WD40 repeat [General function prediction only];
155-405 4.09e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.83  E-value: 4.09e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 155 FEAHENESHAVRWSPVERMVATGGADRKVKLWDIgkNSTEPRAVLSGSSAGINSVDFDSTGAYILGTSNDYGARVWTVMD 234
Cdd:COG2319 158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 235 NRLRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRTLKIWDLRSIACIETkFAGSSC--NDLVTTDSlGSTIISGHYDKKIR 312
Cdd:COG2319 236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRT-LTGHSGgvNSVAFSPD-GKLLASGSDDGTVR 313

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 313 FWDIRTEKQADDVLMP-AKITSLDLSKDCNYLICSVRDDTIKLLDLRKNQVISTFTNEHFKISCdfarASFNSSGLKIAC 391
Cdd:COG2319 314 LWDLATGKLLRTLTGHtGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTS----VAFSPDGRTLAS 389

                       250
                ....*....|....
gi 28572022 392 GSADGAIYIWNVNG 405
Cdd:COG2319 390 GSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 195-442 5.60e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.39  E-value: 5.60e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 195 PRAVLSGSSAGINSVDFDSTGAYILGTSNDYGARVWTVMDNRLRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRTLKIWDL 274
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 275 RSIACIETkFAG--SSCNDLVTTDSlGSTIISGHYDKKIRFWDIRTEKQ-------ADDVlmpakiTSLDLSKDCNYLIC 345
Cdd:cd00200  81 ETGECVRT-LTGhtSYVSSVAFSPD-GRILSSSSRDKTIKVWDVETGKClttlrghTDWV------NSVAFSPDGTFVAS 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 346 SVRDDTIKLLDLRKNQVISTFTNEHFKISCdfarASFNSSGLKIACGSADGAIYIWNVN-GFLEATLKGHSTAVNAVSWS 424
Cdd:cd00200 153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNS----VAFSPDGEKLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAFS 228

                       250
                ....*....|....*...
gi 28572022 425 PNNNMLASVGKNkrCTIY 442
Cdd:cd00200 229 PDGYLLASGSED--GTIR 244
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 150-354 5.44e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.61  E-value: 5.44e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 150 KILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWDIgkNSTEPRAVLSGSSAGINSVDFDSTGAYILGTSNDYGARV 229
Cdd:cd00200  84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV--ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 230 WTVMDNRLRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRTLKIWDLRSIACIETkfaGSSCNDLVTT---DSLGSTIISGH 306
Cdd:cd00200 162 WDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT---LRGHENGVNSvafSPDGYLLASGS 238

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 28572022 307 YDKKIRFWDIRTEKQADDVLMPAK-ITSLDLSKDCNYLICSVRDDTIKL 354
Cdd:cd00200 239 EDGTIRVWDLRTGECVQTLSGHTNsVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 237-443 5.84e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.61  E-value: 5.84e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 237 LRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRTLKIWDLRSIACIETKFAGSSCNDLVTTDSLGSTIISGHYDKKIRFWDI 316
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 317 RTEKQADDVLM-PAKITSLDLSKDCNYLICSVRDDTIKLLDLRKNQVISTFTNehfkISCDFARASFNSSGLKIACGSAD 395
Cdd:cd00200  81 ETGECVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG----HTDWVNSVAFSPDGTFVASSSQD 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 28572022 396 GAIYIWNV-NGFLEATLKGHSTAVNAVSWSPNNNMLASVGKNKRCTIYS 443
Cdd:cd00200 157 GTIKLWDLrTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205
WD40 COG2319
WD40 repeat [General function prediction only];
166-443 1.22e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.42  E-value: 1.22e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 166 RWSPVERMVATGGADRKVKLWDIgkNSTEPRAVLSGSSAGINSVDFDSTGAYILGTSNDYGARVWTVMDNRLRHTLTGHS 245
Cdd:COG2319   1 ALSADGAALAAASADLALALLAA--ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 246 GKVMAAKYVQEPIKVVTGSHDRTLKIWDLRSIACIETKFAGSSCNDLVTTDSLGSTIISGHYDKKIRFWDIRTEKQADDV 325
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 326 LMPAK-ITSLDLSKDCNYLICSVRDDTIKLLDLRKNQVISTFTNEHFKISCdfarASFNSSGLKIACGSADGAIYIWNVN 404
Cdd:COG2319 159 TGHSGaVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS----VAFSPDGKLLASGSADGTVRLWDLA 234

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 28572022 405 -GFLEATLKGHSTAVNAVSWSPNNNMLASVGKNKRCTIYS 443
Cdd:COG2319 235 tGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 150-315 3.16e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.42  E-value: 3.16e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 150 KILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWDIgkNSTEPRAVLSGSSAGINSVDFDSTGAYILGTSNDYGARV 229
Cdd:cd00200 126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL--RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 230 WTVMDNRLRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRTLKIWDLRSIACIETkFAG--SSCNDlVTTDSLGSTIISGHY 307
Cdd:cd00200 204 WDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT-LSGhtNSVTS-LAWSPDGKRLASGSA 281


                ....*...
gi 28572022 308 DKKIRFWD 315
Cdd:cd00200 282 DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
150-232 5.60e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.33  E-value: 5.60e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022 150 KILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWDIgkNSTEPRAVLSGSSAGINSVDFDSTGAYILGTSNDYGARV 229
Cdd:COG2319 321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398


                ...
gi 28572022 230 WTV 232
Cdd:COG2319 399 WDL 401
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 173-357 1.23e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.40  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022  173 MVATGGADRKVKLWDI------GKNSTEPRAVLSGSSAgINSVDFDSTGAYILGTSNDYGA-RVWTVMDNRLRHTLTGHS 245
Cdd:PLN00181 497 FFATAGVNKKIKIFECesiikdGRDIHYPVVELASRSK-LSGICWNSYIKSQVASSNFEGVvQVWDVARSQLVTEMKEHE 575

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022  246 GKVMAAKYVQ-EPIKVVTGSHDRTLKIWDLR---SIACIETKfaGSSCNDLVTTDSlGSTIISGHYDKKIRFWDIRTEKQ 321
Cdd:PLN00181 576 KRVWSIDYSSaDPTLLASGSDDGSVKLWSINqgvSIGTIKTK--ANICCVQFPSES-GRSLAFGSADHKVYYYDLRNPKL 652

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 28572022  322 ADDVLMP-AKITSLDLSKDCNYLICSVRDDTIKLLDL 357
Cdd:PLN00181 653 PLCTMIGhSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
 16-41 6.60e-08

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 49.87  E-value: 6.60e-08
                        10        20
                ....*....|....*....|....*.
gi 28572022  16 QDENRRLLERLMQYKSKDADKLNEEN 41
Cdd:cd22887  66 QEENDELVERWMAKKQQEADKMNEAN 91
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 150-187 2.26e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.26e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 28572022    150 KILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWD 187
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 404-443 6.33e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 6.33e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 28572022    404 NGFLEATLKGHSTAVNAVSWSPNNNMLASVGKNKRCTIYS 443
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
150-187 2.37e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.37e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 28572022   150 KILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWD 187
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 234-273 3.78e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.78e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 28572022    234 DNRLRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRTLKIWD 273
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
235-273 4.07e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 4.07e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 28572022   235 NRLRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRTLKIWD 273
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 16-38 5.90e-05

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 43.38  E-value: 5.90e-05
                          10        20
                  ....*....|....*....|...
gi 28572022    16 QDENRRLLERLMQYKSKDADKLN 38
Cdd:pfam08614 154 EKENRELVERWMKRKGQEAEAMN 176
WD40 pfam00400
WD domain, G-beta repeat;
405-443 1.47e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.47e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 28572022   405 GFLEATLKGHSTAVNAVSWSPNNNMLASVGKNKRCTIYS 443
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 304-366 1.61e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.17  E-value: 1.61e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28572022  304 SGHYDKKIRFWDIRTEKQADDVLMPAKITSLDLSKDCNYLICSVRDDTIKLLDLRKNQVISTF 366
Cdd:PTZ00420 143 SSGFDSFVNIWDIENEKRAFQINMPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSF 205
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 167-274 1.13e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.61  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28572022  167 WSPVERMVATGGADRKVKLWDIGKNSTEPRAVLSGSSAGINSVDFDSTGAYI-----------------LGTSNDYGARV 229
Cdd:PLN00181 560 WDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIgtiktkaniccvqfpseSGRSLAFGSAD 639

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 28572022  230 WTVMDNRLRH------TLTGHSGKVMAAKYVQEPiKVVTGSHDRTLKIWDL 274
Cdd:PLN00181 640 HKVYYYDLRNpklplcTMIGHSKTVSYVRFVDSS-TLVSSSTDNTLKLWDL 689
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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