NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24850109|ref|NP_733800|]
View 

G-protein coupled bile acid receptor 1 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
28-284 1.67e-111

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15905:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 272  Bit Score: 324.78  E-value: 1.67e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109  28 IITANLLLALGIAWDRRLRSPPaGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVH 107
Cdd:cd15905  12 IIFANLFIILGIACNRKLHNTA-NYFFLSLLLADLLTGVALPFIPGMSNESRRGYHSCLFVYVAPNFLFLSFLANLLMVH 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 108 GERYMAVLRPLQP-----PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAA 182
Cdd:cd15905  91 YERYLCIVYPLQYhnfwvHRWVPLALLLTWALPLLFACLPALGWNNWTPGSNCSYKQVFPAAYIYLEVYGLVLPSILAIA 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 183 FLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTL 262
Cdd:cd15905 171 FMSVRVLAVARRQLQDICKLLRAVQRDGPSELEQQLNLRYAKCIAGVSLTFLVCWVPYIAYLLMSVLAIEQRPPLSPGTL 250
                       250       260
                ....*....|....*....|..
gi 24850109 263 LSLLSLGSASAAAVPVAMGLGD 284
Cdd:cd15905 251 LILSCVGSGSAAAVPVILGLGN 272
 
Name Accession Description Interval E-value
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
28-284 1.67e-111

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 324.78  E-value: 1.67e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109  28 IITANLLLALGIAWDRRLRSPPaGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVH 107
Cdd:cd15905  12 IIFANLFIILGIACNRKLHNTA-NYFFLSLLLADLLTGVALPFIPGMSNESRRGYHSCLFVYVAPNFLFLSFLANLLMVH 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 108 GERYMAVLRPLQP-----PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAA 182
Cdd:cd15905  91 YERYLCIVYPLQYhnfwvHRWVPLALLLTWALPLLFACLPALGWNNWTPGSNCSYKQVFPAAYIYLEVYGLVLPSILAIA 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 183 FLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTL 262
Cdd:cd15905 171 FMSVRVLAVARRQLQDICKLLRAVQRDGPSELEQQLNLRYAKCIAGVSLTFLVCWVPYIAYLLMSVLAIEQRPPLSPGTL 250
                       250       260
                ....*....|....*....|..
gi 24850109 263 LSLLSLGSASAAAVPVAMGLGD 284
Cdd:cd15905 251 LILSCVGSGSAAAVPVILGLGN 272
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
109-252 1.09e-05

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 46.14  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109   109 ERYMAVLRPLQPPG--SIRLA---LLLTWAGPLLFASLPAL-GWNHWTPGAN---CSSQaiFPAPYLYLEVY-------G 172
Cdd:pfam00001  82 DRYLAIVHPLRYKRrrTPRRAkvlILVIWVLALLLSLPPLLfGWTLTVPEGNvtvCFID--FPEDLSKPVSYtllisvlG 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109   173 LLLPaVGAAAFLSVRVLATAHRQLQdicRLERAVCRDEPSALARALtwrqaraqAGAMLLFGLCWGPYVATLLLSVLAYE 252
Cdd:pfam00001 160 FLLP-LLVILVCYTLIIRTLRKSAS---KQKSSERTQRRRKALKTL--------AVVVVVFILCWLPYHIVNLLDSLALD 227
 
Name Accession Description Interval E-value
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
28-284 1.67e-111

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 324.78  E-value: 1.67e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109  28 IITANLLLALGIAWDRRLRSPPaGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVH 107
Cdd:cd15905  12 IIFANLFIILGIACNRKLHNTA-NYFFLSLLLADLLTGVALPFIPGMSNESRRGYHSCLFVYVAPNFLFLSFLANLLMVH 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 108 GERYMAVLRPLQP-----PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAA 182
Cdd:cd15905  91 YERYLCIVYPLQYhnfwvHRWVPLALLLTWALPLLFACLPALGWNNWTPGSNCSYKQVFPAAYIYLEVYGLVLPSILAIA 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 183 FLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTL 262
Cdd:cd15905 171 FMSVRVLAVARRQLQDICKLLRAVQRDGPSELEQQLNLRYAKCIAGVSLTFLVCWVPYIAYLLMSVLAIEQRPPLSPGTL 250
                       250       260
                ....*....|....*....|..
gi 24850109 263 LSLLSLGSASAAAVPVAMGLGD 284
Cdd:cd15905 251 LILSCVGSGSAAAVPVILGLGN 272
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
28-249 2.01e-11

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 63.46  E-value: 2.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109  28 IITANLLLALGIAWDRRLRSPP-------------AGCFFLSLllaglltglalpTLPGLWNQSRR-GYWSCLLVYLAPN 93
Cdd:cd00637  12 GLVGNLLVILVILRNRRLRTVTnyfilnlavadllVGLLVIPF------------SLVSLLLGRWWfGDALCKLLGFLQS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109  94 FSFLSLLANLLLVHGERYMAVLRPLQP-----PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAP---- 164
Cdd:cd00637  80 VSLLASILTLTAISVDRYLAIVHPLRYrrrftRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLtlsk 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 165 --YLYLEVYGLLLPAVgAAAFLSVRVLATAHRQLQDIcrleRAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVA 242
Cdd:cd00637 160 ayTIFLFVLLFLLPLL-VIIVCYVRIFRKLRRHRRRI----RSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFI 234

                ....*..
gi 24850109 243 TLLLSVL 249
Cdd:cd00637 235 LLLLDVF 241
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
109-257 4.30e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 53.45  E-value: 4.30e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 109 ERYMAVLRPLQ-----PPGSIRLALLLTWAGPLLFASLPALGWN-HWTPGANCSSQA-IFPAPYLYLEVYGLLLPaVGAA 181
Cdd:cd14972  94 DRYISIVHGLTyvnnvTNKRVKVLIALVWVWSVLLALLPVLGWNcVLCDQESCSPLGpGLPKSYLVLILVFFFIA-LVII 172
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 182 AFLSVRVLATAHRQLQDICRLERAVCRDEPSAlaraltwrqARAQAGAMLL----FGLCWGPYVATLLLSVLAYEQRPPL 257
Cdd:cd14972 173 VFLYVRIFWCLWRHANAIAARQEAAVPAQPST---------SRKLAKTVVIvlgvFLVCWLPLLILLVLDVLCPSVCDIQ 243
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
109-249 1.09e-05

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 46.43  E-value: 1.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 109 ERYMAVLRPLQP-PGSIRLALLL---TWAGPLLFASLPALGWNHWTP---GANCS-----SQAIFPAPYLYLEVYGLLLP 176
Cdd:cd14969  97 ERYLVIVRPLKAfRLSKRRALILiafIWLYGLFWALPPLFGWSSYVPeggGTSCSvdwysKDPNSLSYIVSLFVFCFFLP 176
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24850109 177 aVGAAAFLSVRVLATAHRQLQDICRLERAvcrdEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVL 249
Cdd:cd14969 177 -LAIIIFCYYKIYRTLRKMSKRAARRKNS----AITKRTKKAEKKVAKMVLVMIVAFLIAWTPYAVVSLYVSF 244
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
109-252 1.09e-05

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 46.14  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109   109 ERYMAVLRPLQPPG--SIRLA---LLLTWAGPLLFASLPAL-GWNHWTPGAN---CSSQaiFPAPYLYLEVY-------G 172
Cdd:pfam00001  82 DRYLAIVHPLRYKRrrTPRRAkvlILVIWVLALLLSLPPLLfGWTLTVPEGNvtvCFID--FPEDLSKPVSYtllisvlG 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109   173 LLLPaVGAAAFLSVRVLATAHRQLQdicRLERAVCRDEPSALARALtwrqaraqAGAMLLFGLCWGPYVATLLLSVLAYE 252
Cdd:pfam00001 160 FLLP-LLVILVCYTLIIRTLRKSAS---KQKSSERTQRRRKALKTL--------AVVVVVFILCWLPYHIVNLLDSLALD 227
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
108-259 2.59e-05

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 45.16  E-value: 2.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 108 GERYMAVLRPLQPPGS-----IRLALLLTWAGPLLFASLPALGWNHWTPGANCSSqaIFPapyLYLEVYGLLLPAVGAAA 182
Cdd:cd15349  95 VERYATMVRPVAENTAtktyrVYGMIVLCWILAFLIGFLPLLGWNCLCDFRSCSS--LLP---LYSKSYILFCLVIFFII 169
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24850109 183 FLSVRVLATAhrqlqdICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQ--RPPLGP 259
Cdd:cd15349 170 LLTIIGLYFA------IYCLVRASGQRVISARSRRRSLRLLKTVLMILGAFMVCWGPLFILLLVDFFCSSRscKPLFGM 242
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
109-240 3.88e-05

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 44.63  E-value: 3.88e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 109 ERYMAVLRPLQ-----PPGSIRLALLLTWAGPLLFASLPA-LGWNhwTPGANC-----SSQAIFPAPYLYLEVYGLL--- 174
Cdd:cd15051  97 DRYLAITAPLRypsrvTPRRVAIALAAIWVVSLAVSFLPIhLGWN--TPDGRVqngdtPNQCRFELNPPYVLLVAIGtfy 174
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24850109 175 LPAVGAAAfLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY 240
Cdd:cd15051 175 LPLLIMCG-VYLRIFRIAREQAKRINALTPASTANSSKSAATAREHKATVTLAAVLGAFIICWFPY 239
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
109-251 6.17e-05

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 43.86  E-value: 6.17e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 109 ERYMAVLRPLQPPG--SIRLALL---LTWAGPLLFASLPALGWNHWTP---GANCS----SQAIFPAPYL-YLEVYGLLL 175
Cdd:cd15083  97 DRYLVITRPMKASVriSHRRALIviaVVWLYSLLWVLPPLFGWSRYVLeglLTSCSfdylSRDDANRSYViCLLIFGFVL 176
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 176 PAVGAAA-----FLSVRvlatahrqlqdicRLERAVCRDEPSALARALTWRQARAQA---------GAMLLFGLCWGPYV 241
Cdd:cd15083 177 PLLIIIYcysfiFRAVR-------------RHEKAMKEMAKRFSKSELSSPKARRQAevktakialLLVLLFCLAWTPYA 243
                       170
                ....*....|
gi 24850109 242 ATLLLSVLAY 251
Cdd:cd15083 244 VVALIGQFGY 253
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
108-248 8.81e-05

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 43.61  E-value: 8.81e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 108 GERYMAVLRPLQPPGSIRLALLL----TWAGPLLFASLPALGWNHWTPGANCSSqaIFPapyLYLEVYGLLLPAVGAAAF 183
Cdd:cd15102  95 IERHLTMAKMKPYGASKTSRVLLligaCWLISLLLGGLPILGWNCLGALDACST--VLP---LYSKHYVLFCVTIFAGIL 169
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24850109 184 LSVRVLATAhrqlqdICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSV 248
Cdd:cd15102 170 AAIVALYAR------IYCLVRASGRKATRASASPRSLALLKTVLIVLLVFIACWGPLFILLLLDV 228
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
109-239 4.81e-03

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 38.00  E-value: 4.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 109 ERYMAVLRPL-----QPPGSIRLALLLTWAGPLLFASLPALGWNHWT---PGANC--------SSQAIFpaPYLYLevyG 172
Cdd:cd14981 100 ERFLAITHPFfynshVKKRRARLMLGAVWAFALLIASLPLLGLGSYVlqyPGTWCfldfysknTGDAAY--AYLYS---I 174
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24850109 173 LLLPAVGAAAFLSVRVLATahrqlqdICRLERAVCRDEPSALARAltwRQARAQ-------AGAMLLFGLCWGP 239
Cdd:cd14981 175 LGLLILLVTLLCNLLVIIT-------LLRMRRRKKRHRRSRRSAR---RQKRNEiqmvvllLAITVVFSVCWLP 238
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
109-253 5.37e-03

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 38.07  E-value: 5.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 109 ERYMAVLRPLQPPGSIR-----LALLLTWAGPLLFASLPALGWNHWTPGA---NCSSQAIF--PAPYLY---LEVYGLLL 175
Cdd:cd15337  98 DRYLVIAKPLEAMKKMTfkrafIMIIIIWLWSLLWSIPPFFGWGRYVPEGfqtSCTFDYLSrdLNNRLFilgLFIFGFLC 177
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 176 PaVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARA--LTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQ 253
Cdd:cd15337 178 P-LLIIIFCYVNIIRAVRNHEKEMTQTAKSGMGKDTEKNDARkkAEIRIAKVAIILISLFLLSWTPYAVVALLGQFGPAY 256
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
109-251 6.99e-03

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 37.77  E-value: 6.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 109 ERYMAVLRPLQppgSIR--------LALLLTWAGPLLFASLPALGWNHWTP---GANCSSQAIFPAP-------YLYLEV 170
Cdd:cd15336  97 DRYLVITKPLA---SIRwvskkramIIILLVWLYSLAWSLPPLFGWSAYVPeglLTSCTWDYMTFTPsvraytmLLFCFV 173
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 171 YGLLLPAVGAAAFLSVRVLATAHRQLQdicRLERAVCRDEPSALARALT-WRQARAQAGAMLLFGLCWGPYVATLLLSVL 249
Cdd:cd15336 174 FFIPLGIIIYCYLFIFLAIRSTGREVQ---KLGSQDRKEKAKQYQRMKNeWKMAKIAFVVILLFVLSWSPYACVALIAWA 250

                ..
gi 24850109 250 AY 251
Cdd:cd15336 251 GY 252
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
109-239 7.15e-03

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 37.62  E-value: 7.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 109 ERYMAVLRPLQPPGS-----IRLALLLTWAGPLLFASLPALGWN--------HWTPGANCSSQAIFPAPYL-YLEVYGLL 174
Cdd:cd14968  95 DRYLAIKIPLRYKSLvtgrrAWGAIAVCWVLSFLVGLTPMFGWNngaplesgCGEGGIQCLFEEVIPMDYMvYFNFFACV 174
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24850109 175 LPAVGAAAFLSVRVLATAHRQLQDICRLERAvcRDEPSALARALtwRQARAQAGAMLLFGLCWGP 239
Cdd:cd14968 175 LVPLLIMLVIYLRIFRVIRKQLRQIESLLRS--RRSRSTLQKEV--KAAKSLAIILFLFALCWLP 235
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
81-246 7.85e-03

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 37.45  E-value: 7.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109  81 GYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPL-----QPPGSIRLALLLTWAGPLLFAS--LPALGWNHWTPGA 153
Cdd:cd14971  69 GDFMCKFVHYFQQVSMHASIFTLVAMSLDRFLAVVYPLrslhiRTPRNALAASGCIWVVSLAVAApvLALHRLRNYTPGN 148
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 154 NCSSQAIFPAPY------LYLEVYGLLLPaVGAAAFLSVRVLAtahrqlqdicRLERAVCRDEPSALARALTWRQARAQA 227
Cdd:cd14971 149 RTVCSEAWPSRAhrrafaLCTFLFGYLLP-LLLICVCYAAMLR----------HLWRVAVRPVLSEGSRRAKRKVTRLVL 217
                       170
                ....*....|....*....
gi 24850109 228 GAMLLFGLCWGPYVATLLL 246
Cdd:cd14971 218 VVVVLFAACWGPIHAILLL 236
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
109-248 9.74e-03

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 37.12  E-value: 9.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24850109 109 ERYMAVLRP-----LQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSqaIFP-APYLYLEVY-GLLLPAVGAA 181
Cdd:cd15099  97 DRYLCIYQPsnyklLVTRTRAKVAILLMWCVTIIISFLPLMGWRCKTWDSPCSR--LFPyIDRHYLASWtGLQLVLLFLI 174
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24850109 182 AFLSVRVLATAHRQLQDIcrLERAVCRDEPSALARA-LTWRQARAQAGAMLLFGLCWGPYVATLLLSV 248
Cdd:cd15099 175 IYAYPYILWKAHRHEANM--GGPKLGRQQVKGQARMrMDIRLAKTLSLILLVLAICWLPVLAFMLVDV 240
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH