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Conserved domains on  [gi|25306257|ref|NP_733929|]
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brain-derived neurotrophic factor isoform a preproprotein [Homo sapiens]

Protein Classification

nerve growth factor family protein( domain architecture ID 10639753)

nerve growth factor family protein similar to brain-derived neurotrophic factor (BDNF) and venom nerve growth factor (v-NGF)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NGF smart00140
Nerve growth factor (NGF or beta-NGF); NGF is important for the development and maintenance of ...
133-240 8.24e-66

Nerve growth factor (NGF or beta-NGF); NGF is important for the development and maintenance of the sympathetic and sensory nervous systems.


:

Pssm-ID: 128445  Cd Length: 106  Bit Score: 199.25  E-value: 8.24e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25306257    133 ARRGELSVCDSISEWVTaaDKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQ 212
Cdd:smart00140   1 SHRGEYSVCDSISVWVT--DKTTATDISGNEVTVLGEVPVNNGPLKQYFYETRCKSPNPVKSGCRGIDSRHWNSQCKTTQ 78
                           90       100
                   ....*....|....*....|....*...
gi 25306257    213 SYVRALTMDSKKRIGWRFIRIDTSCVCT 240
Cdd:smart00140  79 TYVRALTSDANKRVGWRFIRIDTACVCV 106
 
Name Accession Description Interval E-value
NGF smart00140
Nerve growth factor (NGF or beta-NGF); NGF is important for the development and maintenance of ...
133-240 8.24e-66

Nerve growth factor (NGF or beta-NGF); NGF is important for the development and maintenance of the sympathetic and sensory nervous systems.


Pssm-ID: 128445  Cd Length: 106  Bit Score: 199.25  E-value: 8.24e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25306257    133 ARRGELSVCDSISEWVTaaDKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQ 212
Cdd:smart00140   1 SHRGEYSVCDSISVWVT--DKTTATDISGNEVTVLGEVPVNNGPLKQYFYETRCKSPNPVKSGCRGIDSRHWNSQCKTTQ 78
                           90       100
                   ....*....|....*....|....*...
gi 25306257    213 SYVRALTMDSKKRIGWRFIRIDTSCVCT 240
Cdd:smart00140  79 TYVRALTSDANKRVGWRFIRIDTACVCV 106
NGF pfam00243
Nerve growth factor family;
134-246 1.22e-59

Nerve growth factor family;


Pssm-ID: 459728  Cd Length: 112  Bit Score: 184.08  E-value: 1.22e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25306257   134 RRGELSVCDSISEWVTaaDKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGY-TKEGCRGIDKRHWNSQCRTTQ 212
Cdd:pfam00243   2 HRGEYSVCDSVSTWVT--NKTTAVDIRGNEVTVLGEVKTNNGVLKQYFFETKCRAGGPgGGSGCRGIDKRHWNSYCKTKQ 79
                          90       100       110
                  ....*....|....*....|....*....|....
gi 25306257   213 SYVRALTMDsKKRIGWRFIRIDTSCVCTLTIKRG 246
Cdd:pfam00243  80 SFVRALTID-KNKVGWRWIRIDTSCVCVLSRKSG 112
 
Name Accession Description Interval E-value
NGF smart00140
Nerve growth factor (NGF or beta-NGF); NGF is important for the development and maintenance of ...
133-240 8.24e-66

Nerve growth factor (NGF or beta-NGF); NGF is important for the development and maintenance of the sympathetic and sensory nervous systems.


Pssm-ID: 128445  Cd Length: 106  Bit Score: 199.25  E-value: 8.24e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25306257    133 ARRGELSVCDSISEWVTaaDKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQ 212
Cdd:smart00140   1 SHRGEYSVCDSISVWVT--DKTTATDISGNEVTVLGEVPVNNGPLKQYFYETRCKSPNPVKSGCRGIDSRHWNSQCKTTQ 78
                           90       100
                   ....*....|....*....|....*...
gi 25306257    213 SYVRALTMDSKKRIGWRFIRIDTSCVCT 240
Cdd:smart00140  79 TYVRALTSDANKRVGWRFIRIDTACVCV 106
NGF pfam00243
Nerve growth factor family;
134-246 1.22e-59

Nerve growth factor family;


Pssm-ID: 459728  Cd Length: 112  Bit Score: 184.08  E-value: 1.22e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25306257   134 RRGELSVCDSISEWVTaaDKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGY-TKEGCRGIDKRHWNSQCRTTQ 212
Cdd:pfam00243   2 HRGEYSVCDSVSTWVT--NKTTAVDIRGNEVTVLGEVKTNNGVLKQYFFETKCRAGGPgGGSGCRGIDKRHWNSYCKTKQ 79
                          90       100       110
                  ....*....|....*....|....*....|....
gi 25306257   213 SYVRALTMDsKKRIGWRFIRIDTSCVCTLTIKRG 246
Cdd:pfam00243  80 SFVRALTID-KNKVGWRWIRIDTSCVCVLSRKSG 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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