NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|159024817|ref|NP_739588|]
View 

Nonstructural protein NS4A [dengue virus type 2]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Flavi_NS4A super family cl03176
Flavivirus non-structural protein NS4A; Flaviviruses encode a single polyprotein. This is ...
 5-127 4.10e-38

Flavivirus non-structural protein NS4A; Flaviviruses encode a single polyprotein. This is cleaved into three structural and seven non-structural proteins. The NS4A protein is small and poorly conserved among the Flaviviruses. NS4A contains multiple hydrophobic potential membrane spanning regions. NS4A has only been found in cells infected by Kunjin virus.


The actual alignment was detected with superfamily member pfam01350:

Pssm-ID: 279666  Cd Length: 144  Bit Score: 125.79  E-value: 4.10e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159024817    5 NLITEMGRLPTFMTQKARDALDNLAVLHTAEAGGRAYNHALSELPETLETLLLLTLLATVTGGIFLFLMSGRGIGKMTLG 84
Cdd:pfam01350   1 DLILEIGELPDFLAKKAGEALDNISMFHHSEEGGKAYRHALEELPDAIEILMLFALAALLTGGMTIFFLSGKGIGKMSIA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 159024817   85 MCCIITASILLWYAQIQPHWIAASIILEFFLIVLLIPEPEKQR 127
Cdd:pfam01350  81 LGCMAACGALLFLAGVEPHHIAASIIIEFFLMVLLIPEPDQQR 123
 
Name Accession Description Interval E-value
Flavi_NS4A pfam01350
Flavivirus non-structural protein NS4A; Flaviviruses encode a single polyprotein. This is ...
 5-127 4.10e-38

Flavivirus non-structural protein NS4A; Flaviviruses encode a single polyprotein. This is cleaved into three structural and seven non-structural proteins. The NS4A protein is small and poorly conserved among the Flaviviruses. NS4A contains multiple hydrophobic potential membrane spanning regions. NS4A has only been found in cells infected by Kunjin virus.


Pssm-ID: 279666  Cd Length: 144  Bit Score: 125.79  E-value: 4.10e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159024817    5 NLITEMGRLPTFMTQKARDALDNLAVLHTAEAGGRAYNHALSELPETLETLLLLTLLATVTGGIFLFLMSGRGIGKMTLG 84
Cdd:pfam01350   1 DLILEIGELPDFLAKKAGEALDNISMFHHSEEGGKAYRHALEELPDAIEILMLFALAALLTGGMTIFFLSGKGIGKMSIA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 159024817   85 MCCIITASILLWYAQIQPHWIAASIILEFFLIVLLIPEPEKQR 127
Cdd:pfam01350  81 LGCMAACGALLFLAGVEPHHIAASIIIEFFLMVLLIPEPDQQR 123
 
Name Accession Description Interval E-value
Flavi_NS4A pfam01350
Flavivirus non-structural protein NS4A; Flaviviruses encode a single polyprotein. This is ...
 5-127 4.10e-38

Flavivirus non-structural protein NS4A; Flaviviruses encode a single polyprotein. This is cleaved into three structural and seven non-structural proteins. The NS4A protein is small and poorly conserved among the Flaviviruses. NS4A contains multiple hydrophobic potential membrane spanning regions. NS4A has only been found in cells infected by Kunjin virus.


Pssm-ID: 279666  Cd Length: 144  Bit Score: 125.79  E-value: 4.10e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159024817    5 NLITEMGRLPTFMTQKARDALDNLAVLHTAEAGGRAYNHALSELPETLETLLLLTLLATVTGGIFLFLMSGRGIGKMTLG 84
Cdd:pfam01350   1 DLILEIGELPDFLAKKAGEALDNISMFHHSEEGGKAYRHALEELPDAIEILMLFALAALLTGGMTIFFLSGKGIGKMSIA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 159024817   85 MCCIITASILLWYAQIQPHWIAASIILEFFLIVLLIPEPEKQR 127
Cdd:pfam01350  81 LGCMAACGALLFLAGVEPHHIAASIIIEFFLMVLLIPEPDQQR 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH