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Conserved domains on  [gi|26986559|ref|NP_758466|]
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lysine-specific histone demethylase 1B isoform 1 [Mus musculus]

Protein Classification

lysine-specific histone demethylase 1B( domain architecture ID 13726372)

lysine-specific histone demethylase 1B (KDM1B) demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor

EC:  1.14.99.66
Gene Symbol:  KDM1B
Gene Ontology:  GO:0008270|GO:0050660|GO:0032452|GO:0042393
PubMed:  23266887|23260659

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02328 super family cl33466
lysine-specific histone demethylase 1 homolog
 308-823 2.77e-94

lysine-specific histone demethylase 1 homolog


The actual alignment was detected with superfamily member PLN02328:

Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 313.47  E-value: 2.77e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  308 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LTVAAGQHLLPKHY 386
Cdd:PLN02328 163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  387 HNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVwddKSFK----GVVVGR--GPQIVNGCINNPVALMCEQL 460
Cdd:PLN02328 237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV---KTMKmkgdGVVAAAdlGGSVLTGINGNPLGVLARQL 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  461 GISMRKLGERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRK---DKTLLQDVPLGEKIEeiyrAFVKESGIQFSEL 537
Cdd:PLN02328 314 GLPLHKVRDICPLYLPDGKAVDAEIDSKIEASFNKLLDRVCKLRQamiEEVKSVDVNLGTALE----AFRHVYKVAEDPQ 389

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  538 EGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVT 617
Cdd:PLN02328 390 ERMLLNWHLANLEYANASLMSNLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVY 468

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  618 TTdGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQR 697
Cdd:PLN02328 469 AG-GQEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMR 544

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  698 GLFAVFYDMDSQQ--SVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSF 773
Cdd:PLN02328 545 GEFFLFYSYSSVSggPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFHPKGIvvPDPVQAVCTRWGKDCFTYGSYSY 624

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 26986559  774 VKTFGSGEAYDIIAEEI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 823
Cdd:PLN02328 625 VAVGSSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-191 8.81e-09

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 51.93  E-value: 8.81e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 26986559   138 YWVQCTKpeCGKWRQLTKEIQlTPHMARTYRCGMKPNtitkpdtPDH--CSFPEDL 191
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPD-------PKYnsCDAPEEI 46
 
Name Accession Description Interval E-value
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 308-823 2.77e-94

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 313.47  E-value: 2.77e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  308 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LTVAAGQHLLPKHY 386
Cdd:PLN02328 163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  387 HNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVwddKSFK----GVVVGR--GPQIVNGCINNPVALMCEQL 460
Cdd:PLN02328 237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV---KTMKmkgdGVVAAAdlGGSVLTGINGNPLGVLARQL 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  461 GISMRKLGERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRK---DKTLLQDVPLGEKIEeiyrAFVKESGIQFSEL 537
Cdd:PLN02328 314 GLPLHKVRDICPLYLPDGKAVDAEIDSKIEASFNKLLDRVCKLRQamiEEVKSVDVNLGTALE----AFRHVYKVAEDPQ 389

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  538 EGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVT 617
Cdd:PLN02328 390 ERMLLNWHLANLEYANASLMSNLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVY 468

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  618 TTdGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQR 697
Cdd:PLN02328 469 AG-GQEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMR 544

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  698 GLFAVFYDMDSQQ--SVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSF 773
Cdd:PLN02328 545 GEFFLFYSYSSVSggPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFHPKGIvvPDPVQAVCTRWGKDCFTYGSYSY 624

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 26986559  774 VKTFGSGEAYDIIAEEI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 823
Cdd:PLN02328 625 VAVGSSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 405-823 8.31e-73

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 245.48  E-value: 8.31e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559   405 RQLHNFGMKVTVLEAKDRIGGRVWDDKsFKGVVVGRGPQIVNGCiNNPVALMCEQLGI----SMRKLGERCDLIQEGGRI 480
Cdd:pfam01593   8 RELLRAGHDVTVLEARDRVGGRIRTVR-DDGFLIELGAMWFHGA-QPPLLALLKELGLedrlVLPDPAPFYTVLFAGGRR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559   481 TDPTVDkRMDFHFNALLDVVSEW----------------RKDKTLLQDVPLGEKIEEIYR-AFVKESGIQFSELEGQVLQ 543
Cdd:pfam01593  86 YPGDFR-RVPAGWEGLLEFGRLLsipeklrlglaalasdALDEFDLDDFSLAESLLFLGRrGPGDVEVWDRLIDPELFAA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559   544 FHLSNLEYACGSSLHQVSArSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAE---GLDIRLKSPVQSIDYTGDEVQVTTTD 620
Cdd:pfam01593 165 LPFASGAFAGDPSELSAGL-ALPLLWALLGEGGSLLLPRGGLGALPDALAAqllGGDVRLNTRVRSIDREGDGVTVTLTD 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559   621 GMGHSAQKVLVTVPLAILQRgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKvqgaDFFGHVPPSASQRGLF 700
Cdd:pfam01593 244 GEVIEADAVIVTVPLGVLKR--ILFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWPDL----GLLGLLSELLTGLGTA 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559   701 AVFYDMDS-----QQSVLMSVIT-GEAVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFV 774
Cdd:pfam01593 318 FSWLTFPNrappgKGLLLLVYVGpGDRARELEGLSDEELLQAVLRDLRKLFGE-EAPEPLRVLVSDWHTDPWPRGSYSLP 396

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 26986559   775 KTFGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 823
Cdd:pfam01593 397 QYGPGHDDYRPLARTPDPGLFFAGEHTSTGYPGTVEGAIESGRRAARAV 445
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
405-825 1.85e-72

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 244.06  E-value: 1.85e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559 405 RQLHNFGMKVTVLEAKDRIGGRVW-DDKSFKGVVVGRGPQIVNGcinNPVALM--CEQLGISMRKL--GERCDLIQEGGR 479
Cdd:COG1231  24 RELRKAGLDVTVLEARDRVGGRVWtLRFGDDGLYAELGAMRIPP---SHTNLLalARELGLPLEPFpnENGNALLYLGGK 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559 480 ITdptvdkRMDFHFNALLDVVSEWRK-DKTLLQDVPLGEKIEEIY-----RAFVKESGIQFSelegqVLQFHLSNLEYAC 553
Cdd:COG1231 101 RV------RAGEIAADLRGVAELLAKlLRALAAALDPWAHPAAELdreslAEWLRRNGASPS-----ARRLLGLLGAGEY 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559 554 GSSLHQVSARSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAEGL--DIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLV 631
Cdd:COG1231 170 GADPDELSLLDLLRYAASAGGGAQQFRIVGGMDQLPRALAAELgdRIRLGAPVTRIRQDGDGVTVTTDDGGTVRADAVIV 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559 632 TVPLAILQRgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFW--DSKVQGADFfghvppsaSQRGLFAVFY---DM 706
Cdd:COG1231 250 TVPPSVLRR--IEFDPPLPAAKRAAIQRLPYGAAIKVFLQFDRPFWeeDGLYGGISL--------TDLPIRQTWYpsnGP 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559 707 DSQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDII 786
Cdd:COG1231 320 DGGAGVLLGYVGGDDARALAALSPEERVAAALEQLARIFGV-YAAEPVDYVSTDWGRDPWSRGAYAAAPPGQLTAAGPAL 398

                       410       420       430
                ....*....|....*....|....*....|....*....
gi 26986559 787 AeEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAA 825
Cdd:COG1231 399 A-EPDGRIHFAGEHTSDEWPGWVEGALESGERAAAEILA 436
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-191 8.81e-09

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 51.93  E-value: 8.81e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 26986559   138 YWVQCTKpeCGKWRQLTKEIQlTPHMARTYRCGMKPNtitkpdtPDH--CSFPEDL 191
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPD-------PKYnsCDAPEEI 46
 
Name Accession Description Interval E-value
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 308-823 2.77e-94

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 313.47  E-value: 2.77e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  308 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LTVAAGQHLLPKHY 386
Cdd:PLN02328 163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  387 HNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVwddKSFK----GVVVGR--GPQIVNGCINNPVALMCEQL 460
Cdd:PLN02328 237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV---KTMKmkgdGVVAAAdlGGSVLTGINGNPLGVLARQL 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  461 GISMRKLGERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRK---DKTLLQDVPLGEKIEeiyrAFVKESGIQFSEL 537
Cdd:PLN02328 314 GLPLHKVRDICPLYLPDGKAVDAEIDSKIEASFNKLLDRVCKLRQamiEEVKSVDVNLGTALE----AFRHVYKVAEDPQ 389

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  538 EGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVT 617
Cdd:PLN02328 390 ERMLLNWHLANLEYANASLMSNLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVY 468

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  618 TTdGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQR 697
Cdd:PLN02328 469 AG-GQEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMR 544

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  698 GLFAVFYDMDSQQ--SVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSF 773
Cdd:PLN02328 545 GEFFLFYSYSSVSggPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFHPKGIvvPDPVQAVCTRWGKDCFTYGSYSY 624

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 26986559  774 VKTFGSGEAYDIIAEEI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 823
Cdd:PLN02328 625 VAVGSSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
PLN03000 PLN03000
amine oxidase
 313-824 3.48e-90

amine oxidase


Pssm-ID: 178578 [Multi-domain]  Cd Length: 881  Bit Score: 303.87  E-value: 3.48e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  313 YLALRNLILALWYTNCKEALTPQKCIphiivrGLVRIRCVQEVERILYFMTRKGLINTGVltVAAGQHLLPKHYHNKSVL 392
Cdd:PLN03000 117 YILIRNHIISKWRENISSWVTKEMFL------GSIPKHCSSLLDSAYNYLVTHGYINFGI--AQAIKDKFPAQSSKSSVV 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  393 VVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDK---SFKGVVVGRGPQIVNGCINNPVALMCEQLGISMRKLGE 469
Cdd:PLN03000 189 IVGAGLSGLAAARQLMRFGFKVTVLEGRKRPGGRVYTKKmeaNRVGAAADLGGSVLTGTLGNPLGIIARQLGSSLYKVRD 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  470 RCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRK---DKTLlqDVPLGEKIEeiyrAFVKESGIQFSELEGQVLQFHL 546
Cdd:PLN03000 269 KCPLYRVDGKPVDPDVDLKVEVAFNQLLDKASKLRQlmgDVSM--DVSLGAALE----TFRQVSGNDVATEEMGLFNWHL 342

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  547 SNLEYACGSSLHQVSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMgHSA 626
Cdd:PLN03000 343 ANLEYANAGLVSKLSLAFWDQDDPY-DMGGDHCFLPGGNGRLVQALAENVPILYEKTVQTIRYGSNGVKVIAGNQV-YEG 420

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  627 QKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFAVFYDM 706
Cdd:PLN03000 421 DMVLCTVPLGVLKNGSIKFVPELPQRKLDCIKRLGFGLLNKVAMLFPYVFWSTDL---DTFGHLTEDPNYRGEFFLFYSY 497

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  707 D--SQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEA 782
Cdd:PLN03000 498 ApvAGGPLLIALVAGEAAHKFETMPPTDAVTRVLHILRGIYEPQGInvPDPLQTVCTRWGGDPFSLGSYSNVAVGASGDD 577

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|...
gi 26986559  783 YDIIAEEI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKIA 824
Cdd:PLN03000 578 YDILAESVgDGRLFFAGEATTRRYPATMHGAFVTGLREAANMA 620
PLN02529 PLN02529
lysine-specific histone demethylase 1
 313-823 5.42e-89

lysine-specific histone demethylase 1


Pssm-ID: 178144 [Multi-domain]  Cd Length: 738  Bit Score: 297.19  E-value: 5.42e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  313 YLALRNLILALWYTNCKEALTpqkciphiivRGLVRIRCVQEVERILY----FMTRKGLINTGVLTVAAGQhlLPKHYHN 388
Cdd:PLN02529  93 YIVVRNHILARWRSNVGIWLS----------KGQIKETVSSEYEHLISaaydFLLYNGYINFGVSPSFASP--IPEEGTE 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  389 KSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDK-SFKG--VVVGRGPQIVNGCINNPVALMCEQLGISMR 465
Cdd:PLN02529 161 GSVIIVGAGLAGLAAARQLLSFGFKVVVLEGRNRPGGRVYTQKmGRKGqfAAVDLGGSVITGIHANPLGVLARQLSIPLH 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  466 KLGERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRK-DKTLLQDVPLGEKIEEIYRAFvkesGIQFSELEGQVLQF 544
Cdd:PLN02529 241 KVRDNCPLYKPDGALVDKEIDSNIEFIFNKLLDKVTELRQiMGGFANDISLGSVLERLRQLY----GVARSTEERQLLDW 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  545 HLSNLEYACGSSLHQVSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMgH 624
Cdd:PLN02529 317 HLANLEYANAGCLSDLSAAYWDQDDPY-EMGGDHCFLAGGNWRLINALCEGVPIFYGKTVDTIKYGNDGVEVIAGSQV-F 394

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  625 SAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFAVFY 704
Cdd:PLN02529 395 QADMVLCTVPLGVLKKRTIRFEPELPRRKLAAIDRLGFGLLNKVAMVFPSVFWGEEL---DTFGCLNESSNKRGEFFLFY 471

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  705 DMD--SQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELF--KEQEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSG 780
Cdd:PLN02529 472 GYHtvSGGPALVALVAGEAAQRFENTDPSTLLHRVLSVLRGIYnpKGINVPDPIQTICTRWGSDPLSYGSYSHVRVQSSG 551

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|...
gi 26986559  781 EAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 823
Cdd:PLN02529 552 SDYDILAESVSGRLFFAGEATTRQYPATMHGAFLSGLREASRI 594
PLN02976 PLN02976
amine oxidase
 389-823 2.03e-77

amine oxidase


Pssm-ID: 215527 [Multi-domain]  Cd Length: 1713  Bit Score: 274.82  E-value: 2.03e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559   389 KSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDKSFKGVVVGRGPQIVNGC--------INNPVALMCEQL 460
Cdd:PLN02976  694 KKIIVVGAGPAGLTAARHLQRQGFSVTVLEARSRIGGRVYTDRSSLSVPVDLGASIITGVeadvaterRPDPSSLICAQL 773

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559   461 GISMRKLGERCDL--IQEGGRITDpTVDKRMDFHFNALLD----VVSE-----------------------------WRK 505
Cdd:PLN02976  774 GLELTVLNSDCPLydVVTGEKVPA-DLDEALEAEYNSLLDdmvlLVAQkgehamkmsledgleyalkrrrmprpgvdIDE 852

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559   506 DKTLLQDVPL--GEKIEEIYRAFVKESGIQF-SELEGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFAQFAGDHTLLT 582
Cdd:PLN02976  853 TELGNAADDLydSASTGVDGGHCEKESKEDVlSPLERRVMNWHFAHLEYGCAALLKEVSLPYWNQDDVYGGFGGAHCMIK 932

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559   583 PGYSTIIEKLAEGLDIRLKSPVQSIDYTGDE----------VQVTTTDGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEK 652
Cdd:PLN02976  933 GGYSNVVESLAEGLDIHLNHVVTDVSYGSKDagasgssrkkVKVSTSNGSEFLGDAVLITVPLGCLKAETIKFSPPLPDW 1012

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559   653 KMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFAVFYDMDSQ--QSVLMSVITGEAVASLRTMDD 730
Cdd:PLN02976 1013 KYSSIQRLGFGVLNKVVLEFPEVFWDDSV---DYFGATAEETDLRGQCFMFWNVKKTvgAPVLIALVVGKAAIDGQSMSS 1089

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559   731 KQVLQQCMGILRELFKEQEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVT 810
Cdd:PLN02976 1090 SDHVNHALMVLRKLFGEALVPDPVASVVTDWGRDPFSYGAYSYVAIGASGEDYDILGRPVENCLFFAGEATCKEHPDTVG 1169

                         490
                  ....*....|...
gi 26986559   811 GAYLSGVREASKI 823
Cdd:PLN02976 1170 GAMMSGLREAVRI 1182
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 405-823 8.31e-73

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 245.48  E-value: 8.31e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559   405 RQLHNFGMKVTVLEAKDRIGGRVWDDKsFKGVVVGRGPQIVNGCiNNPVALMCEQLGI----SMRKLGERCDLIQEGGRI 480
Cdd:pfam01593   8 RELLRAGHDVTVLEARDRVGGRIRTVR-DDGFLIELGAMWFHGA-QPPLLALLKELGLedrlVLPDPAPFYTVLFAGGRR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559   481 TDPTVDkRMDFHFNALLDVVSEW----------------RKDKTLLQDVPLGEKIEEIYR-AFVKESGIQFSELEGQVLQ 543
Cdd:pfam01593  86 YPGDFR-RVPAGWEGLLEFGRLLsipeklrlglaalasdALDEFDLDDFSLAESLLFLGRrGPGDVEVWDRLIDPELFAA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559   544 FHLSNLEYACGSSLHQVSArSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAE---GLDIRLKSPVQSIDYTGDEVQVTTTD 620
Cdd:pfam01593 165 LPFASGAFAGDPSELSAGL-ALPLLWALLGEGGSLLLPRGGLGALPDALAAqllGGDVRLNTRVRSIDREGDGVTVTLTD 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559   621 GMGHSAQKVLVTVPLAILQRgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKvqgaDFFGHVPPSASQRGLF 700
Cdd:pfam01593 244 GEVIEADAVIVTVPLGVLKR--ILFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWPDL----GLLGLLSELLTGLGTA 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559   701 AVFYDMDS-----QQSVLMSVIT-GEAVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFV 774
Cdd:pfam01593 318 FSWLTFPNrappgKGLLLLVYVGpGDRARELEGLSDEELLQAVLRDLRKLFGE-EAPEPLRVLVSDWHTDPWPRGSYSLP 396

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 26986559   775 KTFGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 823
Cdd:pfam01593 397 QYGPGHDDYRPLARTPDPGLFFAGEHTSTGYPGTVEGAIESGRRAARAV 445
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
405-825 1.85e-72

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 244.06  E-value: 1.85e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559 405 RQLHNFGMKVTVLEAKDRIGGRVW-DDKSFKGVVVGRGPQIVNGcinNPVALM--CEQLGISMRKL--GERCDLIQEGGR 479
Cdd:COG1231  24 RELRKAGLDVTVLEARDRVGGRVWtLRFGDDGLYAELGAMRIPP---SHTNLLalARELGLPLEPFpnENGNALLYLGGK 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559 480 ITdptvdkRMDFHFNALLDVVSEWRK-DKTLLQDVPLGEKIEEIY-----RAFVKESGIQFSelegqVLQFHLSNLEYAC 553
Cdd:COG1231 101 RV------RAGEIAADLRGVAELLAKlLRALAAALDPWAHPAAELdreslAEWLRRNGASPS-----ARRLLGLLGAGEY 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559 554 GSSLHQVSARSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAEGL--DIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLV 631
Cdd:COG1231 170 GADPDELSLLDLLRYAASAGGGAQQFRIVGGMDQLPRALAAELgdRIRLGAPVTRIRQDGDGVTVTTDDGGTVRADAVIV 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559 632 TVPLAILQRgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFW--DSKVQGADFfghvppsaSQRGLFAVFY---DM 706
Cdd:COG1231 250 TVPPSVLRR--IEFDPPLPAAKRAAIQRLPYGAAIKVFLQFDRPFWeeDGLYGGISL--------TDLPIRQTWYpsnGP 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559 707 DSQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDII 786
Cdd:COG1231 320 DGGAGVLLGYVGGDDARALAALSPEERVAAALEQLARIFGV-YAAEPVDYVSTDWGRDPWSRGAYAAAPPGQLTAAGPAL 398

                       410       420       430
                ....*....|....*....|....*....|....*....
gi 26986559 787 AeEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAA 825
Cdd:COG1231 399 A-EPDGRIHFAGEHTSDEWPGWVEGALESGERAAAEILA 436
PLN02268 PLN02268
probable polyamine oxidase
 390-823 1.41e-62

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 217.25  E-value: 1.41e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  390 SVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDKSFkGVVVGRGPQIVNG-CINNPVALMCEQLGISM-RKL 467
Cdd:PLN02268   2 SVIVIGGGIAGIAAARALHDASFKVTLLESRDRIGGRVHTDYSF-GFPVDMGASWLHGvCNENPLAPLIGRLGLPLyRTS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  468 G----------ERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRKDKTllQDVPLgekIEEIYRAFVKESGIQFSEL 537
Cdd:PLN02268  81 GdnsvlydhdlESYALFDMDGNQVPQELVTKVGETFERILEETEKVRDEHE--EDMSL---LQAISIVLERHPELRLEGL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  538 EGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFAqfaGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVT 617
Cdd:PLN02268 156 AHEVLQWYLCRMEGWFAADADTISLKSWDQEELLE---GGHGLMVRGYDPVINTLAKGLDIRLNHRVTKIVRRYNGVKVT 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  618 TTDGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSkvqgADFFGHVPPSASQR 697
Cdd:PLN02268 233 VEDGTTFVADAAIIAVPLGVLKANIIKFEPELPEWKEEAISDLGVGIENKIALHFDSVFWPN----VEFLGVVAPTSYGC 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  698 GLFAVFYDMdSQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQeiPEPTKYFVTRWSTEPWIQMAYSFVKTF 777
Cdd:PLN02268 309 SYFLNLHKA-TGHPVLVYMPAGRLARDIEKLSDEAAANFAMSQLKKMLPDA--TEPVQYLVSRWGSDPNSLGCYSYDLVG 385

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 26986559  778 GSGEAYDIIAEEIqGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 823
Cdd:PLN02268 386 KPHDLYERLRAPV-DNLFFAGEATSSDFPGSVHGAYSTGVMAAEEC 430
PLN02676 PLN02676
polyamine oxidase
 390-823 6.26e-38

polyamine oxidase


Pssm-ID: 215362 [Multi-domain]  Cd Length: 487  Bit Score: 148.32  E-value: 6.26e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  390 SVLVVGAGPAGLAAARQLHNFGMK-VTVLEAKDRIGGRVwDDKSFKGVVVGRGP---QIVNGCINNPVALMCEQLGisMR 465
Cdd:PLN02676  28 SVIIVGAGMSGISAAKTLSEAGIEdILILEATDRIGGRM-RKANFAGVSVELGAnwvEGVGGPESNPIWELANKLK--LR 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  466 KLGERCDLI------QEGGRITDPTVDKRMDfhfnaLLDVVSEWrkdKTLLQDVPLGEKIEEIyrafvkeSGIQFSELEG 539
Cdd:PLN02676 105 TFYSDFDNLssniykQDGGLYPKKVVQKSMK-----VADASDEF---GENLSISLSAKKAVDI-------SILTAQRLFG 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  540 Q--------VLQFHLSNLEYA---CGSSLHQVSARSwdhneFFAQFAGDHTLLTP--GYSTIIEKLAEG---------LD 597
Cdd:PLN02676 170 QvpktplemVIDYYNYDYEFAeppRVTSLKNTEPNP-----TFVDFGEDEYFVADprGYESLVYYLAEQflstksgkiTD 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  598 IRLK--SPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYR 675
Cdd:PLN02676 245 PRLKlnKVVREISYSKNGVTVKTEDGSVYRAKYVIVSVSLGVLQSDLIKFKPPLPDWKIEAIYQFDMAVYTKIFLKFPYK 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  676 FWDSKvQGADFFGHvppSASQRGLFAVFYDMDSQ---QSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQeIPE 752
Cdd:PLN02676 325 FWPSG-PGTEFFLY---AHERRGYYPFWQHLENEypgSNVLFVTVTDEESRRIEQQPDSETKAEIMEVLRKMFGPN-IPE 399

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 26986559  753 PTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAEEIqGTVFFAGEATNRHFPQTVTGAYLSGVrEASKI 823
Cdd:PLN02676 400 ATDILVPRWWSNRFFKGSYSNWPIGVSRYEFDQIRAPV-GRVYFTGEHTSEKYNGYVHGAYLAGI-DTAND 468
PLN02568 PLN02568
polyamine oxidase
 413-823 4.75e-33

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 134.96  E-value: 4.75e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  413 KVTVLEAKDRIGGRVwDDKSFKGVVVGRGPQIVNGCINNPV--------ALMCEQLGISMRKLGERCDLIQEGGRITDPT 484
Cdd:PLN02568  35 ELTVVEGGDRIGGRI-NTSEFGGERIEMGATWIHGIGGSPVykiaqeagSLESDEPWECMDGFPDRPKTVAEGGFEVDPS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  485 VDKRMDFHFNALLDVVSEWRKDKTLLQDVPLGEKIE----------------------EIYRAFVKE-------SGIQFS 535
Cdd:PLN02568 114 IVESISTLFRGLMDDAQGKLIEPSEVDEVDFVKLAAkaarvcesggggsvgsflrrglDAYWDSVSAdeqikgyGGWSRK 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  536 ELEGQVLQFHlSNLEyACGSSLHQVSARSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAEGLD---IRLKSPVQSIDYTGD 612
Cdd:PLN02568 194 LLEEAIFTMH-ENTQ-RTYTSADDLSTLDLAAESEYRMFPGEEITIAKGYLSVIEALASVLPpgtIQLGRKVTRIEWQDE 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  613 EVQVTTTDGMGHSAQKVLVTVPLAILQRGAIQ----FNPPLSEKKMKAINSLGAGIIEKIALQFPYRFwDSKVQGAD--- 685
Cdd:PLN02568 272 PVKLHFADGSTMTADHVIVTVSLGVLKAGIGEdsglFSPPLPDFKTDAISRLGFGVVNKLFVELSPRP-DGSPEDVAkfp 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  686 -----FFGHVPPSASQ------RGLfAVFYDMDSQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEIPEP- 753
Cdd:PLN02568 351 flqmaFHRSDSEARHDkipwwmRRT-ASICPIHKNSSVLLSWFAGKEALELEKLSDEEIIRGVQTTLSSFLKRRVAGLGs 429

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  754 --------------------TKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAEEIQGT------------VFFAGEAT 801
Cdd:PLN02568 430 qshplcnggassndgsrwkfVKVLKSKWGTDPLFLGSYSYVAVGSSGDDLDRMAEPLPRIsdhdqaggpplqLLFAGEAT 509

                        490       500
                 ....*....|....*....|..
gi 26986559  802 NRHFPQTVTGAYLSGVREASKI 823
Cdd:PLN02568 510 HRTHYSTTHGAYFSGLREANRL 531
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 405-761 1.79e-11

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 67.16  E-value: 1.79e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559 405 RQLHNFGMKVTVLEAKDRIGGRVwddKSF--KGVVVGRGPQIVngCINNPVAL-MCEQLGIS--MRKLGERCDLIQEGGR 479
Cdd:COG1232  18 YRLAKAGHEVTVLEASDRVGGLI---RTVevDGFRIDRGPHSF--LTRDPEVLeLLRELGLGdeLVWPNTRKSYIYYGGK 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559 480 ITD-PTvdKRMDFHFNALLDVVSEWR-------KDKTLLQDVPLGEKI-----EEIYRAFVKE--SGIqFS----ELEGQ 540
Cdd:COG1232  93 LHPlPQ--GPLALLRSPLLSLAGKLRallellaPRRPPGEDESLAEFVrrrfgREVYERLVEPllEGV-YAgdpdELSAD 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559 541 -VLQFhLSNLEYACGSSLHQVSA--RSWDHNEFFAQFAGdhtlltpGYSTIIEKLAEGL---DIRLKSPVQSIDYTGDEV 614
Cdd:COG1232 170 wAFPR-LKRLELEHGSLIKGALAlrKGAKAGEVFGYLRG-------GLGTLVEALAEALeagEIRLGTRVTAIEREGGGW 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559 615 QVTTTDGMGHSAQKVLVTVPLAILQRgAIQFNPPLSEKKMKAINSLGAGIiekIALQFPyrfwDSKVQGADFFGHVPPSA 694
Cdd:COG1232 242 RVTTSDGETIEADAVVSATPAPALAR-LLAPLPPEVAAALAGIPYASVAV---VALGFD----RPDLPPPDGFGWLVPRD 313

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26986559 695 SQRGLFAVFY------DMDSQQSVLMSV-ITGEAVASLRTMDDKQVLQQCMGILRELFKEQeiPEPTKYFVTRW 761
Cdd:COG1232 314 EGVPILAVTFssnkwpHRAPDGKVLLRLeVGGAGDPELWQLSDEELVALALADLRKLLGID--AEPVDTRVVRW 385
PRK07233 PRK07233
hypothetical protein; Provisional
 584-662 1.16e-09

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 61.44  E-value: 1.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986559  584 GYSTIIEKLAE-----GLDIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRgaiqFNPPLSEK---KMK 655
Cdd:PRK07233 196 GFATLIDALAEaiearGGEIRLGTPVTSVVIDGGGVTGVEVDGEEEDFDAVISTAPPPILAR----LVPDLPADvlaRLR 271


                 ....*..
gi 26986559  656 AINSLGA 662
Cdd:PRK07233 272 RIDYQGV 278
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-191 8.81e-09

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 51.93  E-value: 8.81e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 26986559   138 YWVQCTKpeCGKWRQLTKEIQlTPHMARTYRCGMKPNtitkpdtPDH--CSFPEDL 191
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPD-------PKYnsCDAPEEI 46
SWIRM pfam04433
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid ...
 298-369 5.22e-05

SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins. It contains a helix-turn helix motif and binds to DNA.


Pssm-ID: 461307 [Multi-domain]  Cd Length: 78  Bit Score: 42.16  E-value: 5.22e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26986559   298 DELYEFPEY----SRDPTMYLALRNLILALWYTNCKEALTPQKCiphiivRGLVRIrCVQEVERILYFMTRKGLIN 369
Cdd:pfam04433   9 IEKRLLPEFfngkSKTPEVYLEIRNFILNLWRENPKEYLTKTDA------RRALKG-DVNLISRIHEFLERWGLIN 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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