|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
13-392 |
0e+00 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 517.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAAL 92
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 172
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 173 LLVSALSLHLMACGALLRPLSLTEDAAV---GGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPL 249
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPLALPGDPPApprSLSAAFGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 250 PAAFLLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVL 329
Cdd:cd17423 241 QAAFVVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFSVL 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29336097 330 PELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 392
Cdd:cd17423 321 PELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLILLTLP 383
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
13-392 |
2.63e-99 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 300.62 E-value: 2.63e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAAL 92
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 172
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 173 LLVSALSLHLMACGALLRplsltedaavggpgaqitsLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 252
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR-------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 253 FLLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPEL 332
Cdd:cd17352 222 FLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADL 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 333 VGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 392
Cdd:cd17352 302 VGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
13-391 |
5.14e-85 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 264.30 E-value: 5.14e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAAL 92
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 172
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 173 LLVSALSLHLMACGALLRplsltedaavggpgaqitsLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 252
Cdd:cd17422 161 LVVGALQLNIVVCGALLR-------------------VLKEPGFICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 253 FLLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPE- 331
Cdd:cd17422 222 YMLSAMAIAELFGRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVAGTHIPLLAEd 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 29336097 332 -LVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGsGVLLTL 391
Cdd:cd17422 302 dVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALG-AVFLAL 361
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
3-385 |
1.07e-73 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 237.72 E-value: 1.07e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 3 RRAEPPDGGWGWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPV 82
Cdd:TIGR00892 7 PEGPPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 83 VMTGGILAALGMLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWL 162
Cdd:TIGR00892 87 VIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 163 INNYAWRGALLLVSALSLHLMACGALLRPL--------SLTEDAAVGGPGAQIT---------------SLLRHGPFLRY 219
Cdd:TIGR00892 167 FESFGWRGSFLILGGLLLHCCVCGALMRPVgpsqrvskSKSKEGLPPDGSTKKLskkstaekinrfldfSLFTHRGFLVY 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 220 TAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGD--AVPGPVARLLMLWTTLTGVSLAL 297
Cdd:TIGR00892 247 LSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGlkWIRPHVQYLFSFALLFNGLTHLL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 298 FPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVA 377
Cdd:TIGR00892 327 CALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYAS 406
|
....*...
gi 29336097 378 GAFLLAGS 385
Cdd:TIGR00892 407 GSIVVSAG 414
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
13-385 |
3.93e-60 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 200.04 E-value: 3.93e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAAL 92
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 172
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 173 LLVSALSLHLMACGALLRPLsltedaavgGPgaqitsLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 252
Cdd:cd17427 161 LILGGLLLNCCVAGSLMRPL---------GP------LFKHRGFLIYLSGNVIMFLGFFAPIVFLAPYAKHMGIDEYSAA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 253 FLLSVAAVSDLVGRVASGWLGDA--VPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLP 330
Cdd:cd17427 226 FLLSILAFVDMFARPSMGLVANSkwIRPRIQYFFSFAVMYNGVCHLLCPLAEDYTGLVIYAVFFGFAFGMVSSVLFETLM 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 29336097 331 ELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGS 385
Cdd:cd17427 306 DLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVAS 360
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
13-388 |
1.08e-59 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 198.50 E-value: 1.08e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAAL 92
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 172
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 173 LLVSALSLHLMACGALLRPLsLTEDaavggpgaqitsllrhgpFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 252
Cdd:cd17424 161 LILGGFVLNLCVCGALMRFL-LMPD------------------FLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 253 FLLSVAAVSDLVGRVASGWLGDAVPGPVARLL--MLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLP 330
Cdd:cd17424 222 FLMSILGVIDIIGNITFGWLTDRRCLKKYRYFcyLFAVGMDGLCCLFLPILKTFPLLVPFSFTFGYFDGAYVALIPVVTS 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 29336097 331 ELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVL 388
Cdd:cd17424 302 DVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLL 359
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
13-391 |
2.74e-59 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 197.64 E-value: 2.74e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAAL 92
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 172
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 173 LLVSALSLHLMACGALLRPLSLtedaavggpgaqitSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 252
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRPLDF--------------SVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDIGVPDTEAA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 253 FLLSVAAVSDLVGRVASG------WLGDAVPGPVArLLMLWTTLTGVSLAlfpVAQASSTLVVLAVAYGFTSGALTPVAF 326
Cdd:cd17430 227 FLLSILGFIDIFARPACGvvaglkWVRPRVVYLFS-FAMLFNGLTDLCSA---TAADYGGLVVFCVFFGISYGMVGALQF 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29336097 327 SVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAgSGVLLTL 391
Cdd:cd17430 303 EVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVL-SALFLAL 366
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
13-392 |
3.05e-55 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 187.34 E-value: 3.05e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAAL 92
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGIsSFAFAPLFQWLINNYAWRGAL 172
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGL-TFALAPFTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 173 LLVSALSLHLMACGALLRPLSLtedaavggpgaqitSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 252
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRPIDF--------------SLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARARTLGIDPMDAS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 253 FLLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPEL 332
Cdd:cd17421 226 FIISVAGITETVAQLASGWIADQNWIKKYHYHKAYLILCGVTNLLAPLATTYPLLMTYAVFFAIFCGGYLALLLPVLVDL 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 333 VGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 392
Cdd:cd17421 306 VGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVSFFLEP 365
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
13-385 |
1.55e-52 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 180.07 E-value: 1.55e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAAL 92
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 172
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 173 LLVSALSLHLMACGALLRPLsltedaavgGPGAQIT-SLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPA 251
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRPI---------GPKPFLDlTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISNESA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 252 AFLLSVAAVSDLVGRVASGWLGDA--VPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVL 329
Cdd:cd17426 232 AFLLSILAFVDMVARPSMGIVANTkwVRPRIQYFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFGFAFGWLSSVLFETL 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 29336097 330 PELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGS 385
Cdd:cd17426 312 MDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISS 367
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
13-391 |
7.08e-43 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 154.16 E-value: 7.08e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAAL 92
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 172
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 173 LLVSALSLHLMACGALLRPlsltedaavggpgaqitsLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 252
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP------------------FCSNTRYQIYTLGVTWMVLGFVLPLIYLVPYATSNGMDESKAA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 253 FLLSVAAVSDLVGRVASGWLGD--AVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLP 330
Cdd:cd17425 223 LLLSILGFINIFMRPLAGLLSGlpVFKGRRIYLFSLALLLNGLSNLICAISASFPVLLVYCLLYSISMSGIGSLIFQVLM 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 29336097 331 ELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFvVAGAFLLAGSGVLLTL 391
Cdd:cd17425 303 DTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVF-YASSIFVVSAALFMGL 362
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
13-391 |
6.98e-40 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 146.65 E-value: 6.98e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAAL 92
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACL-SRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGA 171
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVaAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 172 LLLVSALSLHLMACGALLR-------PLSLTEDAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDL 244
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLrrrpadlALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 245 GWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPGPvaRLLMLWTTLTGVSLALFPVAQASSTLVVLAVA-YGFTSGALTP 323
Cdd:cd17355 241 GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPR--RLLAASYALRALGLALLLLLPFPPLALLLFAAlFGLGWGATVP 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 29336097 324 VAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTL 391
Cdd:cd17355 319 LTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
13-392 |
8.94e-39 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 143.05 E-value: 8.94e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAAL 92
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 172
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 173 LLVSALSLHLMACGALLRplsltedaavggpgaqitsLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 252
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR-------------------LFTNKVFVAFIFWALFAYCSFVIPFIHLPEIVKLYGLSEQNDK 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 253 F-LLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSG--ALTPVafsVL 329
Cdd:cd17429 222 FpLTSIIAIVHIFGKVILGIICDLPCISVWNVFILANFTLGVCILILPLMHTYTGLAIVCALIGFSSGyfSLMPV---VT 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29336097 330 PELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 392
Cdd:cd17429 299 EDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGIICLLLKP 361
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
14-392 |
1.66e-36 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 137.70 E-value: 1.66e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 14 WMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALG 93
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 94 MLLASFATSLTHLyLSIGLLSGSGWALTFTPTMACLSRYF-SQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 172
Cdd:COG2223 84 LLLLALAVSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 173 LLVSALSLHLMACGAL-LRPLSLTEDAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQD-LGWDPLP 250
Cdd:COG2223 163 LILGILLLVVAVLAWLfLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAAT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 251 AAFLLSVAAVSDLVGRVASGWLGDAVPGpvARLLMLWTTLTGVSLALFPVAQASSTL-VVLAVAYGFTSGALTPVAFSVL 329
Cdd:COG2223 243 AGLLAALFALLGALGRPLGGWLSDRIGG--RRVLLIVFALMALGLLLLALALGSLWLfLVLFLLLGLALGGGNGAVFALV 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29336097 330 PELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 392
Cdd:COG2223 321 PDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
13-392 |
5.12e-36 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 136.50 E-value: 5.12e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAF-----EEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGG 87
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLtklgdPEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 88 ILAALGMLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYA 167
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 168 WRGALLLVSALSLHLMACGALLRPLSLTEDAAVGGPGAQITS--------------LLRHGPFLRYTAALTLINTGFFIP 233
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSKPGRRTLHsrinlflrkifnveIFKRKRYVIWALGIPLALFGYFVP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 234 YVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPG-PVARLLMLWTTLTGVSLALFPVAQASSTLVVLAV 312
Cdd:cd17420 241 YVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPGvKKMYLQVLSFVSIGLMSMMIPLCNSFGILISVCL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 313 AYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 392
Cdd:cd17420 321 VMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLLFFIP 400
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
13-389 |
3.10e-32 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 125.31 E-value: 3.10e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAAL 92
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 172
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 173 LLVSALSLHLMACGALLRplsltedaavggpgaqitsLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 252
Cdd:cd17428 161 LIVGALALNLLACGSLMR-------------------LFKNRVFSALFIAILLFDIGAFPPSLLMEDVARSENIIEEIAL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 253 F-LLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFsVLPE 331
Cdd:cd17428 222 IpLVSIIGITTAIGKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWSIFPY-VTTK 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 29336097 332 LVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLL 389
Cdd:cd17428 301 TVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLLL 358
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
13-391 |
1.85e-31 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 123.83 E-value: 1.85e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAAL 92
Cdd:COG2807 16 RWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 93 GMLLASFATSLTHLYLSIGLLsGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 172
Cdd:COG2807 96 GLLLRSLAPSVALLLAGTALI-GAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 173 LLVSALSLHLMACGALLRPlSLTEDAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 252
Cdd:COG2807 175 AVWALLALLALLLWLPLLR-RRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 253 FLLSVAAVSDLVGRVASGWLGDAVPGPvARLLMLWTTLTGVSLALFPVAQASSTLVVlAVAYGFTSGALTPVAFSVLPEL 332
Cdd:COG2807 254 LLLSLFQLAGIPGSLLVPLLADRLGDR-RPLLLLLGLLGLAGLLGLLLAPGSLPWLW-AVLLGLGQGGLFPLALTLIGLR 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 333 VGTGRIYC-GMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTL 391
Cdd:COG2807 332 ARTPAEAAaLSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-392 |
4.79e-29 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 116.51 E-value: 4.79e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 6 EPPDGGWGWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMT 85
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 86 GGILAALGMLLASFATSLTHLYLSIGLLsGSGWALTFTPTMACLSRYFS-QRRSLAMGLALTGVGISSFAFAPLFQWLIN 164
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLL-GLGEAGFFPAALKLIAEWFPpKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 165 NYAWRGALllvsalslhlmacgallrplsltedAAVGGPGAqITSLLRhgpFLRYTAALTLINTGFFIPYVHLVAHLQD- 243
Cdd:COG2271 160 AFGWRAAF-------------------------LILGLPGL-LLALLR---FWLLALAYFLVYFALYGFLTWLPTYLVEv 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 244 LGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTP 323
Cdd:COG2271 211 RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFG 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29336097 324 VAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGnYTASFVVAGAFLLAGSGVLLTLP 392
Cdd:COG2271 291 LLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
14-391 |
2.17e-28 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 115.01 E-value: 2.17e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 14 WMVVLSAFFqSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALG 93
Cdd:cd17353 3 WLVLLGAVL-MHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 94 MLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALL 173
Cdd:cd17353 82 FILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 174 LVSALSLHLMACGALL-----------RPLSLTEDAAVGGPGAQITSLLRHGPFLRYTAALTLINTG--FFIPYVHLVAH 240
Cdd:cd17353 162 ILGIIFLIIIVIGAFLirdppkgwvppGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAglMLIGQAKPIGQ 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 241 lQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVpGPVaRLLMLWTTLTGVSLALFPVAQASSTLVVLAVA-YGFTSG 319
Cdd:cd17353 242 -EFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKI-GRK-NTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVAlIGFCYG 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 29336097 320 ALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLrDVTGNYTASFVVAGAFLLAGSGVLLTL 391
Cdd:cd17353 319 GGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYV-LYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
13-389 |
5.03e-28 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 114.05 E-value: 5.03e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAAL 92
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 172
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 173 LLVSALSLHLMACGALLRPLS----LTEDAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIP---YVHLVAHLQDLG 245
Cdd:cd17314 161 TILGILAAIVLSVVSLLGFKEppdnQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFianMASLVRSLQLDA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 246 WDPLPAafLLSVAAVSDLVGRVASGWLGDAVPGpvaRLLMLWTTLT--GVSLALFPVAQAS--STLVVLAVAYGFTSGAL 321
Cdd:cd17314 241 PSFVTK--LMSIYGLFNAFGRLLWGIVADFFGG---RLSTLSILLTilGLGLCAFLFLLKMtpVGLVLTGSLLGFSYGGL 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 29336097 322 TPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLL 389
Cdd:cd17314 316 FTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILL 383
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
13-392 |
5.47e-28 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 113.74 E-value: 5.47e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAAR-----VSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGG 87
Cdd:cd17465 1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDQavqfkTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 88 ILAALGMLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYA 167
Cdd:cd17465 81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 168 WRGALLLVSALSLHLMACGALLRPLSLTEdaavggpgaqitslLRHGPFLRYTAALtlintGFFIPYVHLVAHLQDLGWD 247
Cdd:cd17465 161 LAHTFQVLSLFMFIQIFLSLTYKVFRRKT--------------YRIWAFGIATAVL-----GYFVPYVHLMKYVEEEFKE 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 248 PLPAAFLLSVAAVSDLVGRVASGWLGDAVPGPVA-RLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAF 326
Cdd:cd17465 222 NKREWVLLVCIGASSGIGRLMSGKIGDLIPGLKKiYLQVASFLLLGIMSMMIPLCQVFEGVIVVCLFLGLCDGCFITIMA 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 29336097 327 SVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 392
Cdd:cd17465 302 PIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPIIGGTVLFFVP 367
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
13-392 |
1.33e-26 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 110.27 E-value: 1.33e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAF-----EEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGG 87
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFgskddAQMRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 88 ILAALGMLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYA 167
Cdd:cd17464 81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 168 WRGALLLVSALSLHLMACGALLRPLSLTEDAAVGG-------PGAQI--TSLLRHGPFLRYTAALTLINTGFFIPYVHLV 238
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGKkrkfkcpPLKKIfnFNIWKSTGYRIWAFGIPAALFGYFVPYVHLM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 239 AHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWT-TLTGVSLALFPVAQASSTLVVLAVAYGFT 317
Cdd:cd17464 241 NHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVADYIPGVKKVYLQVSSfFFIGLMSMMIPLCHVFGGLIAVCLFMGLF 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29336097 318 SGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 392
Cdd:cd17464 321 DGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPIIGGIILCFIP 395
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-353 |
4.80e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 99.28 E-value: 4.80e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 7 PPDGGWGWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTG 86
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 87 GILAALGMLLASFATSLTHLYLSiGLLSGSGWALTFTPTMACLSRYFS-QRRSLAMGLALTGVGISSFAFAPLFQWLINN 165
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAA-RFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 166 YAWRGALLLVSALSLHLMACGALLRPLSLTEDAAvgGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQD-L 244
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAARA--RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 245 GWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPGpvARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPV 324
Cdd:COG2814 239 GLSASAAGLLLALFGLGGVLGALLAGRLADRFGR--RRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPL 316
|
330 340
....*....|....*....|....*....
gi 29336097 325 AFSVLPELVGTGRIYCGMGLVQMIESIGG 353
Cdd:COG2814 317 LQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
73-389 |
4.22e-19 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 88.45 E-value: 4.22e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 73 LSTKLGPRPVVMTGGILAALGMLLASFATSLTHLYLSIGLLSGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISS 152
Cdd:cd17475 54 LLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 153 FAFAPLFQWLINNYAWR-GALLLVSALSLHLMACGALLR--PLSLTEDAAVGGPGAQITSLLRHGPFLRYTAALTLINTG 229
Cdd:cd17475 134 ALAAALLPPLALHYGWRaAFVVAGLVSILAAVLFWLFYRepPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAP 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 230 FFIPYVHLVAHLQD-LGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPG----PVARLLMLWTTLTGVSLALFPVAQAS 304
Cdd:cd17475 214 QFALLTFLLLFLHDhLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGgrrrPVLVITAAIAAAALLVLSLLSPGTPL 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 305 STLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAG 384
Cdd:cd17475 294 WLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLA 373
|
....*
gi 29336097 385 SGVLL 389
Cdd:cd17475 374 ALLLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
21-357 |
1.68e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 86.32 E-value: 1.68e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 21 FFQSALVFGVLRSFGVFFVEFVA-AFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALGMLLASF 99
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 100 ATSLTHLYLSiGLLSGSGWALTFTPTMACLSRYFS-QRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALLLVSAL 178
Cdd:pfam07690 82 ASSLWLLLVL-RVLQGLGAGALFPAALALIADWFPpEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 179 SLHLMACGALLRP----LSLTEDAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFL 254
Cdd:pfam07690 161 SLLAAVLLLLPRPppesKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 255 LSVAAVSDLVGRVASGWLGD-AVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELV 333
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDrLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 29336097 334 GTGRIYCGMGLVQMIESIGGLLGA 357
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-389 |
3.26e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 85.71 E-value: 3.26e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 17 VLSAFFQSALVFGVLRSFgvfFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALGMLL 96
Cdd:cd17325 1 LSLALFLDMLGYGIIIPI---LPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 97 ASFATSLTHLYLSIgLLSGSGWALTFTPTMACLSRYF-SQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALLLV 175
Cdd:cd17325 78 FAFATSYWQLLLAR-FLQGLASAAVWPAAMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 176 SALSLHLMACGALLRPLSLTEDAAVGGPGAQITS---LLRHGPFLRYTAALTLIN---TGFFIPYVHLVAHlQDLGWDPL 249
Cdd:cd17325 157 AALALLALVLALLLLPEPRPPPNKRAVSAARLRSglrLLLRDRRLLALFLAIFVLafaFGALEPFLPLYAA-ELGGLSPA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 250 PAAFLLSVAAVSDLVGRVASGWLGDAVPGPvaRLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVL 329
Cdd:cd17325 236 QIGLLFGAQGLASALSQPPAGKLSDRIGRK--PLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 330 PELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGnYTASFVVAGAFLLAGSGVLL 389
Cdd:cd17325 314 ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFL 372
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-389 |
6.01e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 75.93 E-value: 6.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 20 AFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALGMLLASF 99
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 100 ATSLTHLYLsIGLLSGSGWALTFTPTMACLSRYFSQR-RSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALLLVSAL 178
Cdd:cd06174 81 APSFWLLLL-GRFLLGLGSGLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 179 SLHLMACGALLRPLSLTEDAAVGGPGAQ--------ITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQD-LGWDPL 249
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEAssksvlklLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDlGGLSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 250 PAAFLLSVAAVSDLVGRVASGWLGDaVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVL 329
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSD-RLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 330 PELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLL 389
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
14-391 |
7.92e-14 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 72.22 E-value: 7.92e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 14 WMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALG 93
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 94 MLLASFATSLTHLYLSIGLLsGSGWALTFTPTMACLSRYFSQR-RSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 172
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLL-GVAEAGFFPGAIKALAEWFPAReRGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 173 LlvsalslhlmacgallrplsltedaAVGGPGAQITSLLRHgpFLRYTAALTLINTGFFIPYVHLVAHL-----QDLGWD 247
Cdd:cd17319 161 I-------------------------IEGLLGLLLAVLWWF--YLRQVWGLALGYFGINYALYGLLTWLptylkQARGFS 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 248 PLPAAFLLSVAAVSDLVGRVASGWLGDAVPGPVARL-LMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAF 326
Cdd:cd17319 214 LKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLvIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFW 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29336097 327 SVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTL 391
Cdd:cd17319 294 SLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
41-392 |
8.65e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 66.06 E-value: 8.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 41 FVAAFEEQAARVSWIASIGIAVqqfGSPIGSALSTKLGPRPVVMTGGILAALGMLLASFATSLTHLYLSIGLLsGSGWAL 120
Cdd:cd17473 29 FVPNSELLVPLLLTLPALFIAL---FAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALL-GIGVAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 121 TFTPTMACLSRYFS-QRRSLAMGLALTGVGISSFAFAPLFQWLINnYAWRGALLLVSALSLHLMACGALLRPLSLTEDAA 199
Cdd:cd17473 105 IMTLATALIGDYFEgEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLLFLPEPARKSKSA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 200 VGGPGAQITSLLrHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGW-DPLPAAFLLSVAAVSDLVGRVASGWLGDAVPg 278
Cdd:cd17473 184 ASPGAATAAALP-WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLFGRLKRRLG- 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 279 pVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAP 358
Cdd:cd17473 262 -KRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPL 340
|
330 340 350
....*....|....*....|....*....|....
gi 29336097 359 LSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 392
Cdd:cd17473 341 VLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
40-384 |
1.91e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 65.26 E-value: 1.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 40 EFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALGMLLASFATSLTHLYLSiGLLSGSGWA 119
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA-RALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 120 LTFTPTMACLSRYFS-QRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALLLVSALSLHLMACGALLRPLSLTEDA 198
Cdd:cd17324 103 GFWAIAAAYAADLVPpEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 199 AVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGW-DPLPAAFLLSVAAVSDLVGRVASGWLGDAvp 277
Cdd:cd17324 183 GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGfSSSAIIGLLLLFGVAGVVGSPLAGRLADR-- 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 278 GPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRiYCGMGLVQMIESIGGLLGA 357
Cdd:cd17324 261 GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGA 339
|
330 340
....*....|....*....|....*..
gi 29336097 358 PLSGYLRDVTGnYTASFVVAGAFLLAG 384
Cdd:cd17324 340 ALGGLVLDHGG-WAGVGWVGAALLLLA 365
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
16-383 |
2.25e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 64.88 E-value: 2.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 16 VVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVqqfGSPIGSALSTKLGPRPVVMTGGILAALGML 95
Cdd:COG0738 12 AIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLL---ASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 96 LASFATSLTHLYLSIGLLsGSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLIN---NYAWRGAL 172
Cdd:COG0738 89 LFALAPSYPLLLLALFLL-GLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlglSLSWHLPY 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 173 LLVSALSLHLMACGALLR-PLSLTEDAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQD-LGWDPLP 250
Cdd:COG0738 168 LILAVLLLLLALLFLRSKlPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDvLGLSEAT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 251 AAFLLSVAAVSDLVGRVASGWLGDAVPGpvARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLP 330
Cdd:COG0738 248 AALGLSLFWGGMTIGRFLGGFLLKRFGP--VRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLAL 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 29336097 331 ELVGTGRIYcGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLA 383
Cdd:COG0738 326 DGLGKRTAA-AVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLI 377
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
68-384 |
3.62e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 61.07 E-value: 3.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 68 PIGSALSTKLGPRPVVMTGGILAALGMLLASFATSLThLYLSIGLLSGSGWALTFTPTMACLSRYF-SQRRSLAMGLALT 146
Cdd:cd17489 49 PFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA-LLLVLRLIHGIGWGAFTTAAATLVADIIpPSRRGEGIGYYGL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 147 GVGISSFAFAPLFQWLINNYAWRGALLLVSALSLHLMACgALLRPLSLTEDAAVGGPGAQITSLLRHGPFLRYTAALTLI 226
Cdd:cd17489 128 ATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLL-VFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLA 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 227 NTGFFIPYVHLVAHLQDLGWDplPAAFLLSVAAVSDLVGRVASGWLGDAVPGpvARLLMLWTTLTGVSLALFPVAQASST 306
Cdd:cd17489 207 SIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGP--KTVIIPGLLLLALGLLLLSFAGSPWM 282
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 29336097 307 LVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGnYTASFVVAGAFLLAG 384
Cdd:cd17489 283 LLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLA 359
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
21-400 |
4.68e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.07 E-value: 4.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 21 FFQSALVFGVLRSFGVFFVEFVAAFeeQAARVSWIASIGIAVQQFGSPIGSALS----TKLGPR-PVVMTGGILAALGML 95
Cdd:COG2211 19 DLGLNLAFGLLSAYLLYFYTDVLGL--SAALVGLILLVARLWDAITDPLIGALSdrtrTRWGRRrPWILIGAIPLALSFV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 96 LASFATSLTH-----LYLSIGLLSGSGWALTFTPT---MACLSRYFSQRRSLA---MGLALTGVGISSFAFAPLFQWLIN 164
Cdd:COG2211 97 LLFTAPDLSPtgkliYALVTYLLLGLAYTLVNIPYsalGAELTPDYEERTRLSswrFAFAGLGGLLASVLPPPLVAAFGG 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 165 NYA--WRGALLLVSALSLHLMACGALLRPLSLTEDAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQ 242
Cdd:COG2211 177 DAAlgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFK 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 243 D-LGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVpGPVaRLLMLWTTLTGVSLALFPVAQASST--LVVLAVAYGFTSG 319
Cdd:COG2211 257 YvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRF-GKK-KAFIIGLLLAALGLLLLFFLGPGNLwlLLVLAALAGIGLG 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 320 ALTPVAFSVLPELVGTGRIYCG-------MGLVQMIESIGGLLGAPLSGYLRDVTGnYTASFVVAGAFLLAGSGVLLTLP 392
Cdd:COG2211 335 AILVLPWAMLADVVDYDEWKTGrrreglyFGIFTFAIKLGQALAGALAGLLLALFG-YVAGAAQSPSALTGIRLLFFLLP 413
|
....*...
gi 29336097 393 HFFSCISV 400
Cdd:COG2211 414 AVLLLLAA 421
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
220-393 |
3.74e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.97 E-value: 3.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 220 TAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPgpvARLLMLW-TTLTGVSLALF 298
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFG---RKRLLLLgLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 299 PVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGnYTASFVVAG 378
Cdd:cd17325 79 AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCA 157
|
170
....*....|....*
gi 29336097 379 AFLLAGSGVLLTLPH 393
Cdd:cd17325 158 ALALLALVLALLLLP 172
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
208-392 |
1.42e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.14 E-value: 1.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 208 TSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPgpVARLLMLW 287
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFG--RRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 288 TTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVT 367
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180
....*....|....*....|....*
gi 29336097 368 GNYTASFVVAGAFLLAGSGVLLTLP 392
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLP 186
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
49-389 |
3.79e-08 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 55.00 E-value: 3.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 49 AARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALGMLLASFATSLThLYLSIGLLSGSGWALTFTPTMA- 127
Cdd:cd06180 33 YAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFA-ALLALRFLAGAASAFVFVFGSNl 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 128 CLSRYFSQRRSLAMGLALTGVGISSF---AFAPLFQWLINNY--AWRGALLLVSalslhlmACGALLRPLSLTEDAAVGG 202
Cdd:cd06180 112 VLHHATAAGRGHLIGLLFAGVGLGIAlsgLLVPAGLGGGLSWraGWLALALLSA-------VLLLLSFLLLRRGPSAPTE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 203 PGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPGPVAR 282
Cdd:cd06180 185 ASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRAL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 283 LLMLWTTLTGVSLALfpVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCgMGLVQMIESIGGLLGAPLSGY 362
Cdd:cd06180 265 AANLLVQAVGVLLPL--LSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAAPRA-LALMTASFGVGQILGPLLAGW 341
|
330 340
....*....|....*....|....*..
gi 29336097 363 LRDVTGNYTASFVVAGAFLLAGSGVLL 389
Cdd:cd06180 342 LADATGGFAPALILAAAALVVAALLAL 368
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
14-391 |
5.65e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 54.20 E-value: 5.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 14 WMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALG 93
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 94 MLLASFATSLTH---LYLSIGLLSGSGWAltftPTMACLSRYFSQR-RSLAMGLALTGVGISSFAFAPLFQWLINNYAWR 169
Cdd:cd17312 82 NIFMGFSTSLWFfavLWGLNGLFQSMGWP----PCVKLLGNWFSKKeRGTVYGIWSTSHNFGGILAPILAASLASYYGWR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 170 gallLVSALSLHLMACGALLRPLSLTEDAavggPGAQITSLLrhgpflryTAALTLINTGFFipyVHLVAHLQDL-GWDP 248
Cdd:cd17312 158 ----AAFLVPGIVGLVVAIILFFFLRDSP----PYVWVLSLA--------YAFVYIVRYACL---DWGPLYLYEVkGYSL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 249 LPAAFLLSVAAVSDLVGRVASGWLGD-AVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVA-YGFTSGALTPVAF 326
Cdd:cd17312 219 IDAGWFSSLYEVGGIAGTILAGLLSDkLFGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFlIGFFVGGPINLIG 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29336097 327 SVLPELVGTGRIyCG--MGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTL 391
Cdd:cd17312 299 GAAAQDIGRKEA-AGtaTGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
50-390 |
6.08e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 51.03 E-value: 6.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 50 ARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALGMLLASFATSLTHLyLSIGLLSGSGWALTFTPTMACL 129
Cdd:cd17474 34 AQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRALQGIGAAGLGPLALTLI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 130 SRYF-SQRRSLAMGL--ALTGVGISSFafaPLFQWLINNYAWRGALLLVSALSLHLMACGALLRPLSLTEDAAVGGPGAQ 206
Cdd:cd17474 113 GDLFeGGERAKAMGLyeAALGLGIAVG---PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 207 ITSLLRHGPFLRYTAALT-LINTGFF--IPYVHLVAHLqDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPGpVARL 283
Cdd:cd17474 190 DLKKALRGRGLLTFLVSAfLYFFLYFafLTYLPFLLEL-LYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFG-ARRI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 284 LMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYL 363
Cdd:cd17474 268 LVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLL 347
|
330 340
....*....|....*....|....*..
gi 29336097 364 RDVTGNYTASFVVAGAFLLAGSGVLLT 390
Cdd:cd17474 348 LEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
50-391 |
6.55e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 51.02 E-value: 6.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 50 ARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALGMLLASFATSLTHLYLSIgLLSGSGWALTFTPTMACL 129
Cdd:cd17478 31 AQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV-ALAGIGSAAFHPEGARLA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 130 SRYFSQRRSLAMGLALTGvGISSFAFAPLF-QWLINNYAWRGALLLVSALSLHLMACGALLRPLSLTEDAAVGGPGAQIT 208
Cdd:cd17478 110 SQAAGGRRGLAMSIFSVG-GNLGFALGPLIaAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 209 SLLRH-GPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAvpgpVARLLMLW 287
Cdd:cd17478 189 TLKGVwRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDR----FGRRRVII 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 288 TTLTGVSLALFPVAQASSTL-VVLAVAYGFTSGALTPVAFSVLPELVGTGRiycGM--GLVQMIESIGGLLGAPLSGYLR 364
Cdd:cd17478 265 ASLLLAAPFLLLFLLTPGIWsYILLVLAGFLLFASFPVTVVLAQELLPGNV---GLasGLMMGLSFGLGGIGAPVLGALA 341
|
330 340
....*....|....*....|....*..
gi 29336097 365 DVTGNYTASFVVAgafLLAGSGVLLTL 391
Cdd:cd17478 342 DAFGLESVLLILA---LLPLLGALLAF 365
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
68-361 |
6.69e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 51.02 E-value: 6.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 68 PIGSALSTKLGPRPVVMTGGILAALGMLLASFATSLTHLyLSIGLLSGSGWALTFTPTMACLSRYFSQ-RRSLAMGLALT 146
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL-IAARALQGIGAAAIMPASLALIAATFPGeRRGRALGLWGA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 147 GVGISSFAFAPLFQWLINNYAWRgalllvsalslhlmACGALLRPLSLTedAAVGGPgaqitsllrhgPFLRYTAALTLI 226
Cdd:cd17321 128 VVGIGAALGPLLGGLLLELFGWR--------------WIFLINVPIGLV--ALLLAR-----------TFSGAVLAAFLL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 227 NTGFFIPYVHLVAHLQD-LGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAV-PGPVARLLMLWTTLTGVSLALFPVAQAS 304
Cdd:cd17321 181 GAALGGLLFLLPLYLQGvLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFgPRLVLVAGLLLTAVGLLLLALLGADSSV 260
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 29336097 305 STLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSG 361
Cdd:cd17321 261 WLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLG 317
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
52-391 |
1.09e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 50.30 E-value: 1.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 52 VSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALGMLLASFATSLTHLYLSIgLLSGSGWALTFTPTMACLSR 131
Cdd:cd17329 37 VGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIAL-VLTGFGGGLFEPASEAMIAD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 132 yFSQRRSLAMGLALTGVGIS-SFAFAPLFQWLINNYAWRGALLLVSALSLHLMACGALLRPLSLTEDAA--VGGPGAQIT 208
Cdd:cd17329 116 -VTTPENRTRAFSLLYWAINlGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAaeKTEILRGYK 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 209 SLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPL-PAAFLLSVAAVSDLVGRV-ASGWLGDavpGPVARLLML 286
Cdd:cd17329 195 IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGEsLLGLLLALNALLIVLLQFpVARLVER---FRLRKILMI 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 287 WTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDv 366
Cdd:cd17329 272 GILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLD- 350
|
330 340
....*....|....*....|....*
gi 29336097 367 TGNYTASFVVAGAFLLAGSGVLLTL 391
Cdd:cd17329 351 LLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
251-393 |
2.29e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 49.47 E-value: 2.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 251 AAFLLSVAAVSDLVGRVASGWLGDAVPGpvARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLP 330
Cdd:cd17324 36 AGLLVSAYALGYALGALLLGPLSDRIER--RRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAA 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29336097 331 ELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLPH 393
Cdd:cd17324 114 DLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPS 176
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
17-389 |
3.59e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 48.75 E-value: 3.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 17 VLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQ--AARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALGM 94
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGlsLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 95 LLASFATSLTHLY-------LSIGLLSGSGWAL--TFTPtmaclSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINN 165
Cdd:cd17316 81 LLIGLLPTPILLLvlrflqgIGIGGEYPGASTYvaEFAP-----SKRRGFALGLLQSGWALGALLAALVASLLIPLLSGD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 166 YAWRGALllvsalslhlmacgallrplsltedaAVGGPGAQITSLLRhGPFLRYTAALTLINTGFFIPYVHLVAHLQ-DL 244
Cdd:cd17316 156 WGWRILF--------------------------LIGALPALLALLLR-RRTLLLILLWFFISFGYYGLTTFLPTYLQtVL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 245 GWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPV 324
Cdd:cd17316 209 GLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGA 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29336097 325 AFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLL 389
Cdd:cd17316 289 LYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-191 |
9.43e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.56 E-value: 9.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 14 WMVVLSAFFQSALVFGVLrSFGVFFVEFVAAFEEQAArvSWIASIGIAVQQFGSPIGSALSTKLGPR--PVVMTGGILAA 91
Cdd:COG2271 183 WLLALAYFLVYFALYGFL-TWLPTYLVEVRGLSLAQA--GLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 92 LGMLLASFATSLTHLYLSIGLLsGSGWALTFTPTMACLSRYFSQR-RSLAMGLALTGVGISSFAFAPLFQWLINNYAWRG 170
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLA-GFGLGGAFGLLWALAAELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|.
gi 29336097 171 ALLLVSALSLHLMACGALLRP 191
Cdd:COG2271 339 AFLLLAALALLAALLALLLLR 359
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
242-393 |
9.81e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.41 E-value: 9.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 242 QDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPgpVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGAL 321
Cdd:pfam07690 25 EDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG--RRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGAL 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 29336097 322 TPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLPH 393
Cdd:pfam07690 103 FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPP 174
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
225-392 |
1.34e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.82 E-value: 1.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 225 LINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVpGPVaRLLMLWTTLTGVSLALFPVAQAS 304
Cdd:cd17489 7 FFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRF-GRK-RLLLIGLLIFALATLLYLLATSV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 305 STLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGnYTASFVVAGAFLLAG 384
Cdd:cd17489 85 ALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIVAAVLALLA 163
|
....*...
gi 29336097 385 SGVLLTLP 392
Cdd:cd17489 164 LLLVFLVK 171
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
41-391 |
2.54e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 2.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 41 FVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALGMLLASFATSLTHLYLS----IGLLSGS 116
Cdd:cd06173 25 LVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWlllvLAFLLGI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 117 GWALTFTPTMACLSRYFSQRR-SLAMGLALTGVGISSFAFAPLFQWLinnYAWRGALLLVSALSLHLMACGALLRPLSLT 195
Cdd:cd06173 105 ASAFFGPARQALLPELVPKEQlVRANALNSLATQLARIIGPALGGLL---VALLGPGGAFAINALSFLLSALLLLFIRRP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 196 EDAAVGGPGAQITSLLRHG-------PFLRYTAALTLINTGFFIPYVHLVAHL--QDLGWDPLPAAFLLSVAAVSDLVGR 266
Cdd:cd06173 182 PPAAPGESSSLLLRDLREGlrylrrsPLLRLLLLALALFALLGGALTVLLPLLakEVLGGGAAGYGLLLAAFGVGALLGA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 267 VASGWLGDAVPgpVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGT---GRIycgMG 343
Cdd:cd06173 262 LLLGRLSKRRR--RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDelrGRV---FS 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 29336097 344 LVQMIESIGGLLGAPLSGYLRDVTGnYTASFVVAGAFLLAGSGVLLTL 391
Cdd:cd06173 337 VYNALNSGAMPLGALLAGLLADALG-LSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
20-383 |
2.62e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 46.09 E-value: 2.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 20 AFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALGMLLASF 99
Cdd:cd17341 4 SWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 100 ATSLTHLYLSIGLLSGSGWAlTFTPTMACLSRYFSQRRS-----LAMGLALTGVGISSFAFAPLFQWLINN---YAWRgA 171
Cdd:cd17341 84 AVSSYWGLLVLGFLLGFAGA-NFASGQPWASFWFPKEKIggaagGIAGAGNMGVAVSQLLAPLIAGAIVFDggfVGWR-N 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 172 LLLVSALSLHLMACGALLrplsLTEDAAVG-GPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDL-----G 245
Cdd:cd17341 162 AFFVPGILLAIAAVLVLL----FGDDLPTGkASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYfktrfG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 246 WDPLPAAFLLSVAAVSDLVGRVASGWLGDaVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVA 325
Cdd:cd17341 238 LPLVTAGILAALFPLAGALARPAGGWLSD-RFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAG 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 29336097 326 FSVLPELVG--TGRIYCGM-GLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLA 383
Cdd:cd17341 317 NGSVFRMVPfiFRRELGAVtGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVA 377
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
52-389 |
3.06e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 45.65 E-value: 3.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 52 VSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALGMLLASFATSLThLYLSIGLLSGSGWALTFTPTMACLSR 131
Cdd:cd17317 27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE-LFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 132 YFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWrgalllvsalslhlmacgallrpLSLtedaAVGGPGAQITSLL 211
Cdd:cd17317 106 IVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRW-----------------------LQL----AISLPGLLFLLLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 212 RHGPflRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLlsvAAVSDLVGRVASGWLGDAVP-GPVARLLMLWTTL 290
Cdd:cd17317 159 WWLP--RRTIIVGLIWFVTSLVYYGLSLNSSNLGGNLYLNFFL---SGLVEIPAYFLALLLLDRLGrRWTLSGSLLLAGL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 291 TGVSLALFPvAQASSTLVVLAVAYGFTSGAltpvAFSVLP----ELVGTGRIYCGMGLVQMIESIGGLLgAPLSGYLRDV 366
Cdd:cd17317 234 ACLVTALLP-DDENTLALTLALVGKFAISA----AFSVIYlytaELYPTVVRNTGVGLCSTVARVGAIL-APFIVLLGKI 307
|
330 340
....*....|....*....|...
gi 29336097 367 tGNYTASFVVAGAFLLAGSGVLL 389
Cdd:cd17317 308 -GPLLPLIIFGVLALLGGLLTLL 329
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
34-393 |
4.03e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 45.37 E-value: 4.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 34 FGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALGMLLASFATSLTHLyLSIGLL 113
Cdd:cd17371 18 LGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQL-LILRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 114 SGSGWALTFTPTMACLSRYFSQRR-----SLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALLLVSALSLHLMACGAL 188
Cdd:cd17371 97 AGLGFGGEWAAGAALMAEYVPARHrgkalGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 189 LR-PLSLTEDAAVGGPGAQITSLLR--HGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFL-----LSVAAV 260
Cdd:cd17371 177 VKePPQWQAARAARRHFADRPSLRElfSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGLSFEgsagyLVVTIL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 261 SDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVsLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYC 340
Cdd:cd17371 257 GGFLGYLAGGFLADRIGRRNNFALFALGSAISI-LLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRAT 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 29336097 341 GMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLPH 393
Cdd:cd17371 336 AQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPE 388
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
14-130 |
5.09e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.28 E-value: 5.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 14 WMVVLSAFFQSALVFGVLRSFGVFFVEFVaaFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALG 93
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYYFKYV--LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110
....*....|....*....|....*....|....*...
gi 29336097 94 MLLASFATSLTH-LYLSIGLLSGSGWALTFTPTMACLS 130
Cdd:COG2211 308 LLLLFFLGPGNLwLLLVLAALAGIGLGAILVLPWAMLA 345
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
49-393 |
1.13e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.11 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 49 AARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALGMLLASFATSLTHLYLsIGLLSGSGWALTFTPTMAC 128
Cdd:cd17365 33 PAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGLGLGAAMPNAITL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 129 LSRYFS-QRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALllvsalslhlmacgallrplsltedAAVGGPGAQI 207
Cdd:cd17365 112 VSEYAPaRRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVF-------------------------LLGGVPPLIL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 208 TSLLRHGPFLRYTAALTLIntGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAvpGPVARLLMLW 287
Cdd:cd17365 167 LPLLRGTLLLWVTFFMGLL--LVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADR--FGPKRVLALF 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 288 TTLTGVSLALFPVAQASSTLVVLAVaygFTSGALTPVAFSVLPELvgTGRIY------CGMGLVQMIESIGGLLGAPLSG 361
Cdd:cd17365 243 FALGAVSLALLGVSPASLVLLYVLV---FLAGACVNGAQVGLYAL--AARFYptevraTGVGWALGVGRLGAILGPLLGG 317
|
330 340 350
....*....|....*....|....*....|..
gi 29336097 362 YLRDVTGNYTASFVVAGAFLLAGSGVLLTLPH 393
Cdd:cd17365 318 LLLAAGLGPESVFLALAIPAALGALAVLLLRL 349
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
222-395 |
1.29e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.76 E-value: 1.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 222 ALTLINTGFFIPYVHLVAHlQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPGpvaRLLMLW-TTLTGVSLALFPV 300
Cdd:cd17329 9 FLNRLGFFMVWPFMAIYLH-QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGR---KPVMLAgLLLRALGFALLGF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 301 AQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLrdVTGNYTASFVV-AGA 379
Cdd:cd17329 85 AHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL--LLYSFRLLFLAaAVL 162
|
170
....*....|....*.
gi 29336097 380 FLLAGSGVLLTLPHFF 395
Cdd:cd17329 163 FLLAALVLLFLLPETR 178
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
43-170 |
1.87e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 43.50 E-value: 1.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 43 AAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALGMLLASFATSLTHLyLSIGLLSGSGWALTF 122
Cdd:TIGR00895 45 AEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQL-LILRFLAGLGLGGLM 123
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 29336097 123 TPTMACLSRYFSQR-RSLAMGLALTGVGISSFAFAPLFQWLINNYAWRG 170
Cdd:TIGR00895 124 PNLNALVSEYAPKRfRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRS 172
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
215-389 |
1.99e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.30 E-value: 1.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 215 PFLRYTAALTLINTGFFiPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVpgpVARLLMLWTTLTGV- 293
Cdd:cd17370 201 AFWLYLLAVALFALGNF-SFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRI---GRKKLLILGYLSLAl 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 294 SLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGnYTAS 373
Cdd:cd17370 277 AYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS-PSAA 355
|
170
....*....|....*.
gi 29336097 374 FVVAGAFLLAGSGVLL 389
Cdd:cd17370 356 FLFSAVLALIALLLLL 371
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
65-382 |
2.11e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.32 E-value: 2.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 65 FGSPIGSALSTKLGPRPVVMTGGILAALGMLLASFATSLThLYLSIGLLSGSGWALTFTPTMACLSRYFSQR-RSLAMGL 143
Cdd:cd17477 46 LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPW-VWFLLRFVMGIGLAGLFVVSESWLNALATNEnRGRVLGL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 144 ALTGVGISsFAFAPLFQWLINNYAWRGALLLVSALSLHLMACGALLRPLSLTEDAAVGGPGAqitsLLRHGPflryTAAL 223
Cdd:cd17477 125 YSTVLGLG-FALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRR----LLRIAP----LALL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 224 TLINTGFF--IPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPGpvaRLLMLWTTLTGVSLALFPVA 301
Cdd:cd17477 196 GAFVAGFLegAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDR---RRVLLGCALLGALAALLLPL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 302 QASSTLV--VLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGA 379
Cdd:cd17477 273 VPGLPLAllVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAV 352
|
...
gi 29336097 380 FLL 382
Cdd:cd17477 353 ALL 355
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
216-389 |
7.64e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.45 E-value: 7.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 216 FLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPgpvARLLMLWTTLT-GVS 294
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFD---RRRLLILADLLrALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 295 LALFPVAQASST-----LVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGN 369
Cdd:cd06173 78 AAVLALLALLGSlslwlLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGP 157
|
170 180
....*....|....*....|
gi 29336097 370 YTASFVVAGAFLLAGSGVLL 389
Cdd:cd06173 158 GGAFAINALSFLLSALLLLF 177
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
14-160 |
1.10e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.99 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 14 WMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFgspIGSALSTKLGPRPVVMTGGILAALG 93
Cdd:COG0738 213 LLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRF---LGGFLLKRFGPVRLLRLSALLAAVG 289
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29336097 94 MLLASFATSLTHLYLSIGLLsGSGWALTFTPTMACLSRYFSQRRSLAMGLALTgVGISSFAFAPLFQ 160
Cdd:COG0738 290 LLLALLAPGPWLALIGLALV-GLGLSLMFPTIFSLALDGLGKRTAAAVSAVLI-MGIVGGAIGPPLI 354
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
22-383 |
2.16e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.87 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 22 FQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALGMLLASFAT 101
Cdd:cd17330 6 FLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 102 SLTHLYLSIGLLSGSGwaLTFTPTMACLSRYFSQR-RSLAMGL--ALTGVGissFAFAPLFQWLInnyawrgalllvsal 178
Cdd:cd17330 86 NLWLLFLARFLDGLTG--GNVSVAQAYIADITDEEeRAKAFGIisAAFGLG---FILGPALGGFL--------------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 179 slhlmacgALLRPLSLTEDAAVGGPGAQITSLLRHGPFLRYTAALT-LINTGFFIPYVHLVAHL-QDLGWDPLPAAFLLS 256
Cdd:cd17330 146 --------STPYGYALPFLVAAALALLNLVLVLFFLPPLRRLLLVYfLIALAFAGLESVFSLFLkDRFGFSPSQIGLLLA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 257 VAAVSDLVGRVASGWLGDAVPGPVaRLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTG 336
Cdd:cd17330 218 LVGIAGILAQLLLIPRLAKRLGER-KLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSK 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 29336097 337 RIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLA 383
Cdd:cd17330 297 EQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIA 343
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
228-393 |
2.85e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.49 E-value: 2.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 228 TGFFIPYvhLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPGPvaRLLMLWTTLTGVS--LALFPVAQASS 305
Cdd:cd17335 13 LGSLLPF--LSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKR--KALLLLSLLAAVLffLSLFFVAQIFW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 306 TLVVLAVAYGFTSGALTPVAFSVLPELVG-TGRIYcgmGLVQMIESIGGLLGAPLSGYLRDVTG---NYTASFVVAGAFL 381
Cdd:cd17335 89 LLLLLVILGAFFSAPVVPLVDSITLQYLGeERERY---GKQRLWGSIGFGIAALLVGILIDRSStykNYTIAFYVFAVLM 165
|
170
....*....|..
gi 29336097 382 LAGSGVLLTLPH 393
Cdd:cd17335 166 LLALLLALKFPF 177
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
73-391 |
3.29e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.48 E-value: 3.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 73 LSTKLGPRPVVMTGGILAALGMLLASFATSLTHLyLSIGLLSGSGWALTFTPTMACL-SRYFSQRRSLAMGLALTGVGIs 151
Cdd:cd17320 57 LSDRFGRRPVLLAGLLLFILASLLCALASSIEQL-LIARFLQGLGAAAGSVVARAIVrDLYSGAELAKIFSLLMMILAI- 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 152 SFAFAPLF-QWLINNYAWRGALLLVSALSLHLMACGALLRPLSLTEDAAVGGPGAQITS---LLRHGPFLRYTAALTLIN 227
Cdd:cd17320 135 APALAPLLgGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAykrVLKNRRFLGYALALGLSF 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 228 TGFFI-----PYVhlvaHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVpgPVARLLMLWTTLTGVSLALFPVAQ 302
Cdd:cd17320 215 AGLFAylaaaPFI----YIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRF--GPRRLLRLGLLLLLAAALVLLLAA 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 303 ASS---------TLVVLAVAYGFTSGALTPVAFSVLPELVGTgriycGMGLVQMIESIGGLLGAPLSGYLRDVTgnytaS 373
Cdd:cd17320 289 LLGglslwplvaPLFLIFFGFGLIFPNATSLALEPFPHVAGT-----ASALLGFLQFLIGALAGALVGLLPNGT-----A 358
|
330
....*....|....*...
gi 29336097 374 FVVAGAFLLAGSGVLLTL 391
Cdd:cd17320 359 LPMGLLILVLGLLALLLL 376
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
14-301 |
3.52e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.02 E-value: 3.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 14 WMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALG 93
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 94 MLLASFATSLTHLYLSIgLLSGSGWALTFTPTMACLSRYFS-QRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRgal 172
Cdd:COG0477 93 SLLCGLAPSPELLIAAR-ALQGIGAGGLMPGALALIAELFPaRERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR--- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 173 llVSALSLHLMACGALLRPLSLTEDAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 252
Cdd:COG0477 169 --WIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALL 246
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 29336097 253 FLLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVA 301
Cdd:COG0477 247 LLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
80-341 |
4.19e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 39.13 E-value: 4.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 80 RPVVMTGGILAALGMLLA-----SFATSLTHLYLSIGLLSGSGWALTFTP--TM-ACLSRYFSQRRSLA---MGLALTGV 148
Cdd:cd17332 70 RPWLLWGAIPLALLFVLLfttpdGSGTGKLIYALITYILLDLLYTLVNIPytALiPELTDDPEERTSLTswrMFFATIGG 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 149 GISSFAFAPLFQWLINNYAWRGALLLVSALSLHLMAC------GALLRPLSLTEDAAVGGPGAQITSLLRHGPFLRYTAA 222
Cdd:cd17332 150 LLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILllicffGTRERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLA 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 223 LTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVpgPVARLLMLWTTLTGVSLALFPVAQ 302
Cdd:cd17332 230 YLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRF--GKKKAFFIGLLLAILGLLLLFFLP 307
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 29336097 303 ASS--TLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCG 341
Cdd:cd17332 308 PGNlvLILVLAVLAGIGYGGANLLPWAMLADVIDYGELKTG 348
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
15-127 |
4.35e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.08 E-value: 4.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 15 MVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQ------AARVSWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGI 88
Cdd:cd17321 163 ALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQgvlgysPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLL 242
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 29336097 89 LAALGMLLASFATSLTHLYLSIG--LLSGSGWALTFTPTMA 127
Cdd:cd17321 243 LTAVGLLLLALLGADSSVWLLLPglVLLGLGLGLFATPLTN 283
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
55-392 |
4.96e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 38.75 E-value: 4.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 55 IASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALGMLLASFATSLTHLYLS---IGLLSGsgwalTFTPTMACLSR 131
Cdd:cd17390 36 IGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSripLGIFKH-----TQSLCKAYLSD 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 132 YFS-QRRSLAMGL--ALTGVGissFAFAPlfqwlinnyawrgalllvsalslhlmACGALLRPLSltedaavggPGAQIT 208
Cdd:cd17390 111 LVSeQERSRVLGRfnAASSLG---FILGP--------------------------VVGGHLAETD---------GGFYYV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 209 SLLrhgpflryTAALTLINTG---FFIPYVHLV--------------------AHLQDLGWDPLPAAFLLSVAAVSDLVG 265
Cdd:cd17390 153 ALL--------CSAIFILNAGlvwFLLSKLWDLllvrflmgfsvllfrsnfslYLEERFDLSPKTIGYLISYSGVLGALS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 266 RVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLV 345
Cdd:cd17390 225 GFLVGRILKLYKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVG 304
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 29336097 346 QMIESIGGLLGAPLSGYLRDVtgNYTASFVVAGAFLLAGSGVLLTLP 392
Cdd:cd17390 305 QSVTSLARILAPLLSGLLQEF--SVSGPGLLGAVLALAAILLMLARQ 349
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
255-384 |
5.40e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.78 E-value: 5.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 255 LSVAAVSDLVGRVASGWLGDAVPGpvARLLMLwtTLTGVSLALFPVAQASS--TLVVLAVAYGFTSGALTPVAFSVLPEL 332
Cdd:cd17391 246 FSATGVSSLLSAPRLGKLGDRIGH--HRILLG--ALLASALLYIPQAFVQTpwQLGILRFLLGLATGGLLPAINSLLAKI 321
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 29336097 333 V---GTGRIYcgmGLVQMIESIGGLLGAPLSGYLRDVTGnYTASFVVAGAFLLAG 384
Cdd:cd17391 322 TpkeVAGRIF---GYNQSFQYLGNVAGPLLGSAIAAHFG-YRAVFVVTALLVLLN 372
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
15-159 |
7.79e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 38.28 E-value: 7.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 15 MVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARvsWIASIGIAVQQFGSPIGSALSTKLGPRPVVMTGGILAALGM 94
Cdd:cd17369 231 LLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVL--LAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFA 308
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29336097 95 LLASFATSLTHLYLSIG---LLSGSGWALTFTPTMACLSRYFSQR-RSLAMGLALTGVGISSFAFAPLF 159
Cdd:cd17369 309 FPFFWLLDTGSTWLIVLaavVVLGVLHGMMYGPQAAFLAELFPTRvRYTGASLGYQLGAILGGGFAPLI 377
|
|
| ATG22 |
pfam11700 |
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which ... |
309-389 |
9.38e-03 |
|
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which eukaryotes recycle cellular nutrients during stress conditions. Atg22, Avt3 and Avt4 are partially redundant vacuolar effluxes, which mediate the efflux of leucine and other amino acids resulting from autophagy. This family also includes other transporter proteins.
Pssm-ID: 371676 Cd Length: 479 Bit Score: 38.01 E-value: 9.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29336097 309 VLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVL 388
Cdd:pfam11700 387 VLQAFYGLVLGGLRSYSRSLYSELIPRGKEAQFFSLYAITDKGSSWIGPLIVGAIQDRTGNIRSPFVFLAILLVVPLPLL 466
|
.
gi 29336097 389 L 389
Cdd:pfam11700 467 L 467
|
|
| |
