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Conserved domains on  [gi|224994223|ref|NP_766256|]
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low-density lipoprotein receptor-related protein 4 isoform 1 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 505-545 4.06e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 64.93  E-value: 4.06e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 224994223    505 VVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHR 545
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 270-304 5.53e-13

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 64.54  E-value: 5.53e-13
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224994223  270 CTAEQFRCRSGRCVRLSWRCDGEDDCADNSDEENC 304
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
70-105 5.75e-13

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 64.58  E-value: 5.75e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224994223    70 TCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDC 105
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 808-850 1.02e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.77  E-value: 1.02e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224994223    808 EVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMR 850
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 590-632 5.35e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.85  E-value: 5.35e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224994223    590 RIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHR 632
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1179-1219 5.61e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 61.79  E-value: 5.61e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 224994223  1179 GFMYWTDWGENAKLERSGMDGSDRTVLINNNLGWPNGLTVD 1219
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1483-1524 7.37e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 61.41  E-value: 7.37e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223  1483 GYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDY 1524
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1507-1547 1.04e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 1.04e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 224994223   1507 KVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGK 1547
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 895-937 1.10e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 1.10e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224994223    895 QVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKR 937
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 871-912 2.12e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 60.25  E-value: 2.12e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223   871 GYMYWTDWGASPKIERAGMDASSRQVIISSNLTWPNGLAIDY 912
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1085-1277 2.59e-11

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd05819:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 269  Bit Score: 66.19  E-value: 2.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1085 AIGVDPlEGKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTD-----GLAVDAIGRkVYWTDTGTNRIEVGNLDGSMRK 1159
Cdd:cd05819    59 GVAVDS-DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLT 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1160 VL-----VWQNLDSPRAIVLYHEmGFMYWTDWGENA--KLERSG--MDGSDRTVLINNNLGWPNGLTVDktSSQLLW-AD 1229
Cdd:cd05819   137 TFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNHRiqVFDPDGnfLTTFGSTGTGPGQFNYPTGIAVD--SDGNIYvAD 213

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 224994223 1230 AHTERIEVADLNGA------NRHTLVSPVQHPYGLTLLDS-YIYWTDWQTRSIHR 1277
Cdd:cd05819   214 SGNNRVQVFDPDGAgfggngNFLGSDGQFNRPSGLAVDSDgNLYVADTGNNRIQV 268
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1313-1348 3.32e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 59.56  E-value: 3.32e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224994223  1313 CGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDRKTC 1348
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 231-265 3.61e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 3.61e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224994223  231 CRSGEFMCDSGLCINSGWRCDGDADCDDQSDERNC 265
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-182 4.71e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.14  E-value: 4.71e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224994223  148 CSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEESC 182
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 110-142 9.23e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 9.23e-11
                          10        20        30
                  ....*....|....*....|....*....|...
gi 224994223  110 CEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ 142
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
Vgb super family cl26743
Streptogramin lyase [Defense mechanisms];
1359-1583 2.46e-10

Streptogramin lyase [Defense mechanisms];


The actual alignment was detected with superfamily member COG4257:

Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 63.50  E-value: 2.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1359 SSRGSIRRisLDTDDHTDVHVPVPGLNNVISLDYDSvHGKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTD-GLAVDw 1437
Cdd:COG4257    35 QGGGRIGR--LDPATGEFTEYPLGGGSGPHGIAVDP-DGNLWFTDNGNNRIGRIDPKTGEITTFALPGGGSNPhGIAFD- 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1438 VARNLYWTDTGRNTIeaSRLDGSCRKVLINNSLDE---PRAIAVFPrKGYLFWTDWG--HIAKIERAnlDGSERKVLINT 1512
Cdd:COG4257   111 PDGNLWFTDQGGNRI--GRLDPATGEVTEFPLPTGgagPYGIAVDP-DGNLWVTDFGanAIGRIDPD--TGTLTEYALPT 185

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 224994223 1513 DLGWPNGLTLDYDTRrIYWVDA---HLDRIESADlnGKLRQVLVS-HVSHPFALT-QQDRWIYWTDWQTKSIQRVD 1583
Cdd:COG4257   186 PGAGPRGLAVDPDGN-LWVADTgsgRIGRFDPKT--GTVTEYPLPgGGARPYGVAvDGDGRVWFAESGANRIVRFD 258
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
749-982 6.33e-10

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 61.63  E-value: 6.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  749 RMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTN 828
Cdd:COG3391     1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  829 KLYWTDAGTDRIEVANTDgSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASpKIerAGMDASSRQVIISSNL-TWPNG 907
Cdd:COG3391    81 RLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVgAGPHG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  908 LAIDYGSQRLYWADAGMKTIE--FAGLDGSKRKVL----IGSQlPHPFGLTLYGQRIYWTDWQT-KSIQSADRLTGLDRE 980
Cdd:COG3391   157 IAVDPDGKRLYVANSGSNTVSviVSVIDTATGKVVatipVGGG-PVGVAVSPDGRRLYVANRGSnTSNGGSNTVSVIDLA 235


                  ..
gi 224994223  981 TL 982
Cdd:COG3391   236 TL 237
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1006-1043 1.74e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 54.56  E-value: 1.74e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 224994223  1006 CAVENGGCSHLCLrsPNPSGFSCTCPTGINLLRDGKTC 1043
Cdd:pfam14670    1 CSVNNGGCSHLCL--NTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 566-607 2.12e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.47  E-value: 2.12e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223   566 GTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDY 607
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 311-343 2.86e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.79  E-value: 2.86e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 224994223    311 QCASDQFLCWNGRCIGQRKLCNGINDCGDSSDE 343
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-66 4.80e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 4.80e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 224994223   27 CGRSHFTCAVSalgecTCIPAQWQCDGDNDCGDHSDEDGC 66
Cdd:cd00112     1 CPPNEFRCANG-----RCIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 358-393 2.62e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.09  E-value: 2.62e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224994223   358 CNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGRTC 393
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 702-729 8.90e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 49.93  E-value: 8.90e-08
                           10        20
                   ....*....|....*....|....*...
gi 224994223   702 CGDNNGGCTHLCLPSGQNYTCACPTGFR 729
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYE 28
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 460-502 1.61e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.44  E-value: 1.61e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224994223    460 YTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNV 502
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
395-434 1.93e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.93e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 224994223    395 DVNECAEEGYCSQG--CTNTEGAFQCWCEAGYElrpDRRSCK 434
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYT---DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1617-1648 3.01e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 3.01e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224994223  1617 CGVNNGGCTHLCFARASDFVCACPD----EPDGHPC 1648
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEgyelQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 633-673 1.09e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.05  E-value: 1.09e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224994223    633 KAVISQGLPHP--FAITVFEDSLYWTDWHTKSINSANkFTGKN 673
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN-LDGTN 42
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 505-545 4.06e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 64.93  E-value: 4.06e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 224994223    505 VVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHR 545
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 270-304 5.53e-13

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 64.54  E-value: 5.53e-13
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224994223  270 CTAEQFRCRSGRCVRLSWRCDGEDDCADNSDEENC 304
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
70-105 5.75e-13

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 64.58  E-value: 5.75e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224994223    70 TCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDC 105
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 808-850 1.02e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.77  E-value: 1.02e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224994223    808 EVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMR 850
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 71-105 4.56e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 4.56e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224994223   71 CSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDC 105
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 590-632 5.35e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.85  E-value: 5.35e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224994223    590 RIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHR 632
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1179-1219 5.61e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 61.79  E-value: 5.61e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 224994223  1179 GFMYWTDWGENAKLERSGMDGSDRTVLINNNLGWPNGLTVD 1219
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1483-1524 7.37e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 61.41  E-value: 7.37e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223  1483 GYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDY 1524
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1507-1547 1.04e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 1.04e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 224994223   1507 KVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGK 1547
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 895-937 1.10e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 1.10e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224994223    895 QVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKR 937
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 871-912 2.12e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 60.25  E-value: 2.12e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223   871 GYMYWTDWGASPKIERAGMDASSRQVIISSNLTWPNGLAIDY 912
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1085-1277 2.59e-11

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 66.19  E-value: 2.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1085 AIGVDPlEGKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTD-----GLAVDAIGRkVYWTDTGTNRIEVGNLDGSMRK 1159
Cdd:cd05819    59 GVAVDS-DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLT 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1160 VL-----VWQNLDSPRAIVLYHEmGFMYWTDWGENA--KLERSG--MDGSDRTVLINNNLGWPNGLTVDktSSQLLW-AD 1229
Cdd:cd05819   137 TFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNHRiqVFDPDGnfLTTFGSTGTGPGQFNYPTGIAVD--SDGNIYvAD 213

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 224994223 1230 AHTERIEVADLNGA------NRHTLVSPVQHPYGLTLLDS-YIYWTDWQTRSIHR 1277
Cdd:cd05819   214 SGNNRVQVFDPDGAgfggngNFLGSDGQFNRPSGLAVDSDgNLYVADTGNNRIQV 268
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1313-1348 3.32e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 59.56  E-value: 3.32e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224994223  1313 CGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDRKTC 1348
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 231-265 3.61e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 3.61e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224994223  231 CRSGEFMCDSGLCINSGWRCDGDADCDDQSDERNC 265
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 270-301 3.70e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 59.18  E-value: 3.70e-11
                            10        20        30
                    ....*....|....*....|....*....|..
gi 224994223    270 CTAEQFRCRSGRCVRLSWRCDGEDDCADNSDE 301
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-182 4.71e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.14  E-value: 4.71e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224994223  148 CSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEESC 182
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
230-265 4.99e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 59.18  E-value: 4.99e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224994223   230 PCRSGEFMCDSGLCINSGWRCDGDADCDDQSDERNC 265
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 70-102 5.15e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.80  E-value: 5.15e-11
                            10        20        30
                    ....*....|....*....|....*....|...
gi 224994223     70 TCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDE 102
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
146-182 7.38e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.41  E-value: 7.38e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 224994223   146 RKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEESC 182
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 110-142 9.23e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 9.23e-11
                          10        20        30
                  ....*....|....*....|....*....|...
gi 224994223  110 CEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ 142
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 109-141 9.82e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.03  E-value: 9.82e-11
                            10        20        30
                    ....*....|....*....|....*....|...
gi 224994223    109 ECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDE 141
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1359-1583 2.46e-10

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 63.50  E-value: 2.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1359 SSRGSIRRisLDTDDHTDVHVPVPGLNNVISLDYDSvHGKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTD-GLAVDw 1437
Cdd:COG4257    35 QGGGRIGR--LDPATGEFTEYPLGGGSGPHGIAVDP-DGNLWFTDNGNNRIGRIDPKTGEITTFALPGGGSNPhGIAFD- 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1438 VARNLYWTDTGRNTIeaSRLDGSCRKVLINNSLDE---PRAIAVFPrKGYLFWTDWG--HIAKIERAnlDGSERKVLINT 1512
Cdd:COG4257   111 PDGNLWFTDQGGNRI--GRLDPATGEVTEFPLPTGgagPYGIAVDP-DGNLWVTDFGanAIGRIDPD--TGTLTEYALPT 185

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 224994223 1513 DLGWPNGLTLDYDTRrIYWVDA---HLDRIESADlnGKLRQVLVS-HVSHPFALT-QQDRWIYWTDWQTKSIQRVD 1583
Cdd:COG4257   186 PGAGPRGLAVDPDGN-LWVADTgsgRIGRFDPKT--GTVTEYPLPgGGARPYGVAvDGDGRVWFAESGANRIVRFD 258
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
270-304 2.60e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 2.60e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 224994223   270 CTAEQFRCRSGRCVRLSWRCDGEDDCADNSDEENC 304
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 147-179 2.74e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 2.74e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 224994223    147 KCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDE 179
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
756-923 3.15e-10

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 62.40  E-value: 3.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  756 SFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISraKWD-GTGQEVVVDTSLESPAGLAIDWVTNKLYWTD 834
Cdd:COG3391    51 GGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVS--VIDlATGKVVATIPVGGGPRGLAVDPDGGRLYVAD 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  835 AGTDRIEVANTDgSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGaSPKIER--AGMDASSRQVI--ISSNLTwPNGLAI 910
Cdd:COG3391   129 SGNGRVSVIDTA-TGKVVATIPVGAGPHGIAVDPDGKRLYVANSG-SNTVSVivSVIDTATGKVVatIPVGGG-PVGVAV 205

                         170
                  ....*....|...
gi 224994223  911 DYGSQRLYWADAG 923
Cdd:COG3391   206 SPDGRRLYVANRG 218
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 231-262 4.13e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.49  E-value: 4.13e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 224994223    231 CRSGEFMCDSGLCINSGWRCDGDADCDDQSDE 262
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
749-982 6.33e-10

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 61.63  E-value: 6.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  749 RMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTN 828
Cdd:COG3391     1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  829 KLYWTDAGTDRIEVANTDgSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASpKIerAGMDASSRQVIISSNL-TWPNG 907
Cdd:COG3391    81 RLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVgAGPHG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  908 LAIDYGSQRLYWADAGMKTIE--FAGLDGSKRKVL----IGSQlPHPFGLTLYGQRIYWTDWQT-KSIQSADRLTGLDRE 980
Cdd:COG3391   157 IAVDPDGKRLYVANSGSNTVSviVSVIDTATGKVVatipVGGG-PVGVAVSPDGRRLYVANRGSnTSNGGSNTVSVIDLA 235


                  ..
gi 224994223  981 TL 982
Cdd:COG3391   236 TL 237
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1463-1506 7.91e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.69  E-value: 7.91e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 224994223   1463 KVLINNSLDEPRAIAVFPRKGYLFWTDWGHiAKIERANLDGSER 1506
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1118-1158 1.20e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 1.20e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 224994223   1118 IITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMR 1158
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1420-1460 1.29e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 1.29e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 224994223   1420 ETVIGHGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGS 1460
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1006-1043 1.74e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 54.56  E-value: 1.74e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 224994223  1006 CAVENGGCSHLCLrsPNPSGFSCTCPTGINLLRDGKTC 1043
Cdd:pfam14670    1 CSVNNGGCSHLCL--NTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 566-607 2.12e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.47  E-value: 2.12e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223   566 GTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDY 607
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
110-142 2.83e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.18  E-value: 2.83e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 224994223   110 CEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ 142
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 311-343 2.86e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.79  E-value: 2.86e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 224994223    311 QCASDQFLCWNGRCIGQRKLCNGINDCGDSSDE 343
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 471-622 3.61e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 59.64  E-value: 3.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  471 IALDFHHRrelVFWSDVTLDRILRANLNGSNVEEVVSTG-----LESPGGLAVDwVHDKLYWTDSGTSRIEVANLDGahR 545
Cdd:cd05819   107 IAVDSSGN---IYVADTGNHRIQKFDPDGEFLTTFGSGGsgpgqFNGPTGVAVD-SDGNIYVADTGNHRIQVFDPDG--N 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  546 KVLLW-------QSLEKPRAIALHPmEGTIYWTDWGNTpRI-----EASSMDGSGRRIIADTHLFWPNGLTIDYAGrRMY 613
Cdd:cd05819   181 FLTTFgstgtgpGQFNYPTGIAVDS-DGNIYVADSGNN-RVqvfdpDGAGFGGNGNFLGSDGQFNRPSGLAVDSDG-NLY 257


                  ....*....
gi 224994223  614 WVDAKHHVI 622
Cdd:cd05819   258 VADTGNNRI 266
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 312-349 4.10e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 4.10e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224994223  312 CASDQFLCWNGRCIGQRKLCNGINDCGDSSDEspqQNC 349
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE---ENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-66 4.80e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 4.80e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 224994223   27 CGRSHFTCAVSalgecTCIPAQWQCDGDNDCGDHSDEDGC 66
Cdd:cd00112     1 CPPNEFRCANG-----RCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 546-589 6.74e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 6.74e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 224994223    546 KVLLWQSLEKPRAIALHPMEGTIYWTDWGnTPRIEASSMDGSGR 589
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 358-393 2.62e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.09  E-value: 2.62e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224994223   358 CNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGRTC 393
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 523-563 2.81e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 2.81e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223   523 DKLYWTDSGTS-RIEVANLDGAHRKVLLWQSLEKPRAIALHP 563
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 610-650 3.01e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 3.01e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223   610 RRMYWVDAK-HHVIERANLDGSHRKAVISQGLPHPFAITVFE 650
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 702-729 8.90e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 49.93  E-value: 8.90e-08
                           10        20
                   ....*....|....*....|....*...
gi 224994223   702 CGDNNGGCTHLCLPSGQNYTCACPTGFR 729
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYE 28
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1384-1582 1.74e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 54.63  E-value: 1.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1384 LNNVISLDYDSvHGKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTD-----GLAVDwVARNLYWTDTGRNTIEASRLD 1458
Cdd:cd05819    54 FNEPAGVAVDS-DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVD-SSGNIYVADTGNHRIQKFDPD 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1459 GSCRKVL-----INNSLDEPRAIAVFPrKGYLFWTDWGHiAKIERANLDGSERKVL-----INTDLGWPNGLTLDYDTrR 1528
Cdd:cd05819   132 GEFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTGN-HRIQVFDPDGNFLTTFgstgtGPGQFNYPTGIAVDSDG-N 208

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 224994223 1529 IYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQ-------QDRWIYWTDWQTKSIQRV 1582
Cdd:cd05819   209 IYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQFNRpsglavdSDGNLYVADTGNNRIQVF 269
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 27-63 2.61e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.40  E-value: 2.61e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 224994223     27 CGRSHFTCAVSalgecTCIPAQWQCDGDNDCGDHSDE 63
Cdd:smart00192    2 CPPGEFQCDNG-----RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
27-66 2.68e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 2.68e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 224994223    27 CGRSHFTCAVSalgecTCIPAQWQCDGDNDCGDHSDEDGC 66
Cdd:pfam00057    3 CSPNEFQCGSG-----ECIPRSWVCDGDPDCGDGSDEENC 37
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1031-1234 4.30e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 53.16  E-value: 4.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1031 PTGINLLRDGKTCSPGMNSFLIFARRIDVRMVSLDIPYFADVVVPINMTMKNTIAIGVDPLEGK-VYWSDSTLHRISRAS 1109
Cdd:COG3391    17 ALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRrLYVANSGSGRVSVID 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1110 LDGSQHEDIITTGlQTTDGLAVDAIGRKVYWTDTGTNRIEVgnLDGSMRKVL-VWQNLDSPRAIVLYHEMGFMYWTDWGE 1188
Cdd:COG3391    97 LATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGS 173

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 224994223 1189 N--AKLErSGMDGSDRTVLINNNLG-WPNGLTVDKTSSQLLWADAHTER 1234
Cdd:COG3391   174 NtvSVIV-SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNT 221
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 828-868 4.36e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.92  E-value: 4.36e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223   828 NKLYWTDAGTD-RIEVANTDGSMRTVLIWENLDRPRDIVVEP 868
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1136-1176 8.41e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.15  E-value: 8.41e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223  1136 RKVYWTDTGT-NRIEVGNLDGSMRKVLVWQNLDSPRAIVLYH 1176
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1440-1480 1.04e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.77  E-value: 1.04e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223  1440 RNLYWTDTG-RNTIEASRLDGSCRKVLINNSLDEPRAIAVFP 1480
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
311-349 1.24e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.47  E-value: 1.24e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 224994223   311 QCASDQFLCWNGRCIGQRKLCNGINDCGDSSDEspqQNC 349
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE---ENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 852-894 1.32e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 1.32e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224994223    852 VLIWENLDRPRDIVVEPMGGYMYWTDWGaSPKIERAGMDASSR 894
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 460-502 1.61e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.44  E-value: 1.61e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224994223    460 YTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNV 502
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
395-434 1.93e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.93e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 224994223    395 DVNECAEEGYCSQG--CTNTEGAFQCWCEAGYElrpDRRSCK 434
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYT---DGRNCE 39
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 766-806 1.56e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.74  E-value: 1.56e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 224994223    766 VIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTG 806
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 774-969 1.92e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 48.47  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  774 SAVALDwdsRDDHVYWTDV--------STDTISRAKWDGTGQEvvvDTSLESPAGLAIDwVTNKLYWTDAGTDRIEVANT 845
Cdd:cd05819    58 AGVAVD---SDGNLYVADTgnhriqkfDPDGNFLASFGGSGDG---DGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  846 DGSMRTVL-----IWENLDRPRDIVVEPmGGYMYWTDWGASpKIERagMDASSRQV-------IISSNLTWPNGLAIDyG 913
Cdd:cd05819   131 DGEFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTGNH-RIQV--FDPDGNFLttfgstgTGPGQFNYPTGIAVD-S 205

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 224994223  914 SQRLYWADAGMK-----TIEFAGLDGSKRKVLIGSQLPHPFGLTL--YGqRIYWTDWQTKSIQ 969
Cdd:cd05819   206 DGNIYVADSGNNrvqvfDPDGAGFGGNGNFLGSDGQFNRPSGLAVdsDG-NLYVADTGNNRIQ 267
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 395-427 2.07e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.07e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224994223  395 DVNECAEEGYCSQG--CTNTEGAFQCWCEAGYELR 427
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYTGR 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 785-825 2.74e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.92  E-value: 2.74e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223   785 DHVYWTDVSTD-TISRAKWDGTGQEVVVDTSLESPAGLAIDW 825
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1617-1648 3.01e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 3.01e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224994223  1617 CGVNNGGCTHLCFARASDFVCACPD----EPDGHPC 1648
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEgyelQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 915-954 7.03e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.76  E-value: 7.03e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 224994223   915 QRLYWADAGMK-TIEFAGLDGSKRKVLIGSQLPHPFGLTLY 954
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1159-1202 8.60e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 8.60e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 224994223   1159 KVLVWQNLDSPRAIVLYHEMGFMYWTDWGeNAKLERSGMDGSDR 1202
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 633-673 1.09e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.05  E-value: 1.09e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224994223    633 KAVISQGLPHP--FAITVFEDSLYWTDWHTKSINSANkFTGKN 673
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN-LDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 399-433 2.37e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.92  E-value: 2.37e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224994223   399 CAEE-GYCSQGCTNTEGAFQCWCEAGYELRPDRRSC 433
Cdd:pfam14670    1 CSVNnGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 480-520 6.89e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.07  E-value: 6.89e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223   480 ELVFWSDVTLD-RILRANLNGSNVEEVVSTGLESPGGLAVDW 520
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1527-1563 5.44e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 36.37  E-value: 5.44e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 224994223  1527 RRIYWVDAHLD-RIESADLNGKLRQVLVSH-VSHPFALT 1563
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDdLQHPNAIA 39
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 505-545 4.06e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 64.93  E-value: 4.06e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 224994223    505 VVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHR 545
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 270-304 5.53e-13

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 64.54  E-value: 5.53e-13
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224994223  270 CTAEQFRCRSGRCVRLSWRCDGEDDCADNSDEENC 304
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
70-105 5.75e-13

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 64.58  E-value: 5.75e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224994223    70 TCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDC 105
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 808-850 1.02e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.77  E-value: 1.02e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224994223    808 EVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMR 850
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 71-105 4.56e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 4.56e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224994223   71 CSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDC 105
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 590-632 5.35e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.85  E-value: 5.35e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224994223    590 RIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHR 632
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1179-1219 5.61e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 61.79  E-value: 5.61e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 224994223  1179 GFMYWTDWGENAKLERSGMDGSDRTVLINNNLGWPNGLTVD 1219
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1483-1524 7.37e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 61.41  E-value: 7.37e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223  1483 GYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDY 1524
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1507-1547 1.04e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 1.04e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 224994223   1507 KVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGK 1547
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 895-937 1.10e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 1.10e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224994223    895 QVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKR 937
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 871-912 2.12e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 60.25  E-value: 2.12e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223   871 GYMYWTDWGASPKIERAGMDASSRQVIISSNLTWPNGLAIDY 912
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1085-1277 2.59e-11

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 66.19  E-value: 2.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1085 AIGVDPlEGKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTD-----GLAVDAIGRkVYWTDTGTNRIEVGNLDGSMRK 1159
Cdd:cd05819    59 GVAVDS-DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLT 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1160 VL-----VWQNLDSPRAIVLYHEmGFMYWTDWGENA--KLERSG--MDGSDRTVLINNNLGWPNGLTVDktSSQLLW-AD 1229
Cdd:cd05819   137 TFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNHRiqVFDPDGnfLTTFGSTGTGPGQFNYPTGIAVD--SDGNIYvAD 213

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 224994223 1230 AHTERIEVADLNGA------NRHTLVSPVQHPYGLTLLDS-YIYWTDWQTRSIHR 1277
Cdd:cd05819   214 SGNNRVQVFDPDGAgfggngNFLGSDGQFNRPSGLAVDSDgNLYVADTGNNRIQV 268
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1313-1348 3.32e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 59.56  E-value: 3.32e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224994223  1313 CGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDRKTC 1348
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 231-265 3.61e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 3.61e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224994223  231 CRSGEFMCDSGLCINSGWRCDGDADCDDQSDERNC 265
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 270-301 3.70e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 59.18  E-value: 3.70e-11
                            10        20        30
                    ....*....|....*....|....*....|..
gi 224994223    270 CTAEQFRCRSGRCVRLSWRCDGEDDCADNSDE 301
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-182 4.71e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.14  E-value: 4.71e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224994223  148 CSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEESC 182
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
230-265 4.99e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 59.18  E-value: 4.99e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224994223   230 PCRSGEFMCDSGLCINSGWRCDGDADCDDQSDERNC 265
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 70-102 5.15e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.80  E-value: 5.15e-11
                            10        20        30
                    ....*....|....*....|....*....|...
gi 224994223     70 TCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDE 102
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
146-182 7.38e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.41  E-value: 7.38e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 224994223   146 RKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEESC 182
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 110-142 9.23e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 9.23e-11
                          10        20        30
                  ....*....|....*....|....*....|...
gi 224994223  110 CEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ 142
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 109-141 9.82e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.03  E-value: 9.82e-11
                            10        20        30
                    ....*....|....*....|....*....|...
gi 224994223    109 ECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDE 141
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1359-1583 2.46e-10

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 63.50  E-value: 2.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1359 SSRGSIRRisLDTDDHTDVHVPVPGLNNVISLDYDSvHGKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTD-GLAVDw 1437
Cdd:COG4257    35 QGGGRIGR--LDPATGEFTEYPLGGGSGPHGIAVDP-DGNLWFTDNGNNRIGRIDPKTGEITTFALPGGGSNPhGIAFD- 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1438 VARNLYWTDTGRNTIeaSRLDGSCRKVLINNSLDE---PRAIAVFPrKGYLFWTDWG--HIAKIERAnlDGSERKVLINT 1512
Cdd:COG4257   111 PDGNLWFTDQGGNRI--GRLDPATGEVTEFPLPTGgagPYGIAVDP-DGNLWVTDFGanAIGRIDPD--TGTLTEYALPT 185

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 224994223 1513 DLGWPNGLTLDYDTRrIYWVDA---HLDRIESADlnGKLRQVLVS-HVSHPFALT-QQDRWIYWTDWQTKSIQRVD 1583
Cdd:COG4257   186 PGAGPRGLAVDPDGN-LWVADTgsgRIGRFDPKT--GTVTEYPLPgGGARPYGVAvDGDGRVWFAESGANRIVRFD 258
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
270-304 2.60e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 2.60e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 224994223   270 CTAEQFRCRSGRCVRLSWRCDGEDDCADNSDEENC 304
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 147-179 2.74e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 2.74e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 224994223    147 KCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDE 179
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
756-923 3.15e-10

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 62.40  E-value: 3.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  756 SFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISraKWD-GTGQEVVVDTSLESPAGLAIDWVTNKLYWTD 834
Cdd:COG3391    51 GGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVS--VIDlATGKVVATIPVGGGPRGLAVDPDGGRLYVAD 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  835 AGTDRIEVANTDgSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGaSPKIER--AGMDASSRQVI--ISSNLTwPNGLAI 910
Cdd:COG3391   129 SGNGRVSVIDTA-TGKVVATIPVGAGPHGIAVDPDGKRLYVANSG-SNTVSVivSVIDTATGKVVatIPVGGG-PVGVAV 205

                         170
                  ....*....|...
gi 224994223  911 DYGSQRLYWADAG 923
Cdd:COG3391   206 SPDGRRLYVANRG 218
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 231-262 4.13e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.49  E-value: 4.13e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 224994223    231 CRSGEFMCDSGLCINSGWRCDGDADCDDQSDE 262
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
749-982 6.33e-10

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 61.63  E-value: 6.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  749 RMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTN 828
Cdd:COG3391     1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  829 KLYWTDAGTDRIEVANTDgSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASpKIerAGMDASSRQVIISSNL-TWPNG 907
Cdd:COG3391    81 RLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVgAGPHG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  908 LAIDYGSQRLYWADAGMKTIE--FAGLDGSKRKVL----IGSQlPHPFGLTLYGQRIYWTDWQT-KSIQSADRLTGLDRE 980
Cdd:COG3391   157 IAVDPDGKRLYVANSGSNTVSviVSVIDTATGKVVatipVGGG-PVGVAVSPDGRRLYVANRGSnTSNGGSNTVSVIDLA 235


                  ..
gi 224994223  981 TL 982
Cdd:COG3391   236 TL 237
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1463-1506 7.91e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.69  E-value: 7.91e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 224994223   1463 KVLINNSLDEPRAIAVFPRKGYLFWTDWGHiAKIERANLDGSER 1506
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1118-1158 1.20e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 1.20e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 224994223   1118 IITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMR 1158
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1420-1460 1.29e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 1.29e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 224994223   1420 ETVIGHGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGS 1460
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1006-1043 1.74e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 54.56  E-value: 1.74e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 224994223  1006 CAVENGGCSHLCLrsPNPSGFSCTCPTGINLLRDGKTC 1043
Cdd:pfam14670    1 CSVNNGGCSHLCL--NTPGGYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
482-636 1.86e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 60.09  E-value: 1.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  482 VFWSDVTLDRILRANLNGSNVEEVVSTGlESPGGLAVDWVHDKLYWTDSGTSRIEVanLDGAHRKVLL-WQSLEKPRAIA 560
Cdd:COG3391    82 LYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVAtIPVGAGPHGIA 158

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 224994223  561 LHPMEGTIYWTDWGNtPRIEA--SSMDGSGRRIIADTHL-FWPNGLTIDYAGRRMYWVDAKHHvieRANLdGSHRKAVI 636
Cdd:COG3391   159 VDPDGKRLYVANSGS-NTVSVivSVIDTATGKVVATIPVgGGPVGVAVSPDGRRLYVANRGSN---TSNG-GSNTVSVI 232
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 566-607 2.12e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.47  E-value: 2.12e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223   566 GTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDY 607
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
110-142 2.83e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.18  E-value: 2.83e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 224994223   110 CEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ 142
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 311-343 2.86e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.79  E-value: 2.86e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 224994223    311 QCASDQFLCWNGRCIGQRKLCNGINDCGDSSDE 343
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 471-622 3.61e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 59.64  E-value: 3.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  471 IALDFHHRrelVFWSDVTLDRILRANLNGSNVEEVVSTG-----LESPGGLAVDwVHDKLYWTDSGTSRIEVANLDGahR 545
Cdd:cd05819   107 IAVDSSGN---IYVADTGNHRIQKFDPDGEFLTTFGSGGsgpgqFNGPTGVAVD-SDGNIYVADTGNHRIQVFDPDG--N 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  546 KVLLW-------QSLEKPRAIALHPmEGTIYWTDWGNTpRI-----EASSMDGSGRRIIADTHLFWPNGLTIDYAGrRMY 613
Cdd:cd05819   181 FLTTFgstgtgpGQFNYPTGIAVDS-DGNIYVADSGNN-RVqvfdpDGAGFGGNGNFLGSDGQFNRPSGLAVDSDG-NLY 257


                  ....*....
gi 224994223  614 WVDAKHHVI 622
Cdd:cd05819   258 VADTGNNRI 266
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 312-349 4.10e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 4.10e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224994223  312 CASDQFLCWNGRCIGQRKLCNGINDCGDSSDEspqQNC 349
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE---ENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-66 4.80e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 4.80e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 224994223   27 CGRSHFTCAVSalgecTCIPAQWQCDGDNDCGDHSDEDGC 66
Cdd:cd00112     1 CPPNEFRCANG-----RCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 546-589 6.74e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 6.74e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 224994223    546 KVLLWQSLEKPRAIALHPMEGTIYWTDWGnTPRIEASSMDGSGR 589
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 780-927 1.59e-08

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 57.98  E-value: 1.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  780 WDsRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSlESPAGLAID-----WVTN---KLYWTDAGTDRIEVANTDGSMRt 851
Cdd:COG3386    15 WD-PDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDpdgrlLVADhgrGLVRFDPADGEVTVLADEYGKP- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  852 vliwenLDRPRDIVVEPMGGYmYWTDwgaSPKIERAG----MDASSRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTI 927
Cdd:COG3386    92 ------LNRPNDGVVDPDGRL-YFTD---MGEYLPTGalyrVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRI 161
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1204-1245 2.00e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.83  E-value: 2.00e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 224994223   1204 VLINNNLGWPNGLTVDKTSSQLLWADAHTERIEVADLNGANR 1245
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 358-393 2.62e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.09  E-value: 2.62e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224994223   358 CNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGRTC 393
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 523-563 2.81e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 2.81e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223   523 DKLYWTDSGTS-RIEVANLDGAHRKVLLWQSLEKPRAIALHP 563
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 610-650 3.01e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 3.01e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223   610 RRMYWVDAK-HHVIERANLDGSHRKAVISQGLPHPFAITVFE 650
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 702-729 8.90e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 49.93  E-value: 8.90e-08
                           10        20
                   ....*....|....*....|....*...
gi 224994223   702 CGDNNGGCTHLCLPSGQNYTCACPTGFR 729
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYE 28
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1384-1582 1.74e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 54.63  E-value: 1.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1384 LNNVISLDYDSvHGKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTD-----GLAVDwVARNLYWTDTGRNTIEASRLD 1458
Cdd:cd05819    54 FNEPAGVAVDS-DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVD-SSGNIYVADTGNHRIQKFDPD 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1459 GSCRKVL-----INNSLDEPRAIAVFPrKGYLFWTDWGHiAKIERANLDGSERKVL-----INTDLGWPNGLTLDYDTrR 1528
Cdd:cd05819   132 GEFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTGN-HRIQVFDPDGNFLTTFgstgtGPGQFNYPTGIAVDSDG-N 208

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 224994223 1529 IYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQ-------QDRWIYWTDWQTKSIQRV 1582
Cdd:cd05819   209 IYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQFNRpsglavdSDGNLYVADTGNNRIQVF 269
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 27-63 2.61e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.40  E-value: 2.61e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 224994223     27 CGRSHFTCAVSalgecTCIPAQWQCDGDNDCGDHSDE 63
Cdd:smart00192    2 CPPGEFQCDNG-----RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
27-66 2.68e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 2.68e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 224994223    27 CGRSHFTCAVSalgecTCIPAQWQCDGDNDCGDHSDEDGC 66
Cdd:pfam00057    3 CSPNEFQCGSG-----ECIPRSWVCDGDPDCGDGSDEENC 37
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 503-657 3.08e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 54.13  E-value: 3.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  503 EEVVSTGLESPGGLAVDwVHDKLYWTDSGTSRIEVanLDGAHRKVLLW-----QSLEKPRAIALHPmEGTIYWTDWGNTp 577
Cdd:cd14962     4 EERPKEALTRPYGVAAD-GRGRIYVADTGRGAVFV--FDLPNGKVFVIgnagpNRFVSPIGVAIDA-NGNLYVSDAELG- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  578 RIEASSMDGSGRRIIADTHLFW-PNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQG-----LPHPFAITVF-E 650
Cdd:cd14962    79 KVFVFDRDGKFLRAIGAGALFKrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRGsgpgeFNLPTDLAVDrD 158


                  ....*..
gi 224994223  651 DSLYWTD 657
Cdd:cd14962   159 GNLYVTD 165
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1031-1234 4.30e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 53.16  E-value: 4.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1031 PTGINLLRDGKTCSPGMNSFLIFARRIDVRMVSLDIPYFADVVVPINMTMKNTIAIGVDPLEGK-VYWSDSTLHRISRAS 1109
Cdd:COG3391    17 ALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRrLYVANSGSGRVSVID 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1110 LDGSQHEDIITTGlQTTDGLAVDAIGRKVYWTDTGTNRIEVgnLDGSMRKVL-VWQNLDSPRAIVLYHEMGFMYWTDWGE 1188
Cdd:COG3391    97 LATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGS 173

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 224994223 1189 N--AKLErSGMDGSDRTVLINNNLG-WPNGLTVDKTSSQLLWADAHTER 1234
Cdd:COG3391   174 NtvSVIV-SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNT 221
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 828-868 4.36e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.92  E-value: 4.36e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223   828 NKLYWTDAGTD-RIEVANTDGSMRTVLIWENLDRPRDIVVEP 868
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 482-657 7.04e-07

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 52.60  E-value: 7.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  482 VFWSDVTLDRILR--AnlnGSNVEEVVS-TGLESPGGLAVDwVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQSLEKPRA 558
Cdd:cd14952    23 VYVADSGNNRVLKlaA---GSTTQTVLPfTGLYQPQGVAVD-AAGTVYVTDFGNNRVLKLAAGSTTQTVLPFTGLNDPTG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  559 IALHPmEGTIYWTDWGNTpRIeASSMDGSGRRIIAD-THLFWPNGLTIDYAGrRMYWVDAKHHVIERANLdGSHRKAVIS 637
Cdd:cd14952    99 VAVDA-AGNVYVADTGNN-RV-LKLAAGSNTQTVLPfTGLSNPDGVAVDGAG-NVYVTDTGNNRVLKLAA-GSTTQTVLP 173

                         170       180
                  ....*....|....*....|..
gi 224994223  638 -QGLPHPFAITV-FEDSLYWTD 657
Cdd:cd14952   174 fTGLNSPSGVAVdTAGNVYVTD 195
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1136-1176 8.41e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.15  E-value: 8.41e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223  1136 RKVYWTDTGT-NRIEVGNLDGSMRKVLVWQNLDSPRAIVLYH 1176
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 502-658 8.91e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 52.68  E-value: 8.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  502 VEEVVSTGLESPGGLAVDwvHDKLYWTDSGTSRIEVANLDGahrKVLLW--------QSLEKPRAIALHPmEGTIYWTDW 573
Cdd:cd14963    93 PEKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEG---KLLLEfgkpgsepGELSYPNGIAVDE-DGNIYVADS 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  574 GNTpRIEASSMDGSGRRIIA-----DTHLFWPNGLTIDYAGrRMYWVDAKHHVIERANLDGSHRKAVISQG-----LPHP 643
Cdd:cd14963   167 GNG-RIQVFDKNGKFIKELNgspdgKSGFVNPRGIAVDPDG-NLYVVDNLSHRVYVFDEQGKELFTFGGRGkddgqFNLP 244

                         170
                  ....*....|....*.
gi 224994223  644 FAITVFEDS-LYWTDW 658
Cdd:cd14963   245 NGLFIDDDGrLYVTDR 260
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1440-1480 1.04e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.77  E-value: 1.04e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223  1440 RNLYWTDTG-RNTIEASRLDGSCRKVLINNSLDEPRAIAVFP 1480
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
311-349 1.24e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.47  E-value: 1.24e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 224994223   311 QCASDQFLCWNGRCIGQRKLCNGINDCGDSSDEspqQNC 349
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE---ENC 37
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 477-630 1.32e-06

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 51.82  E-value: 1.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  477 HRRELVFWSDVTLDRILRANLNGSNVEEVVSTGlESPGGLAVDWvHDKLYWTDSGtSRIEVANLDGAHRKVLLwQSLEKP 556
Cdd:COG3386    16 DPDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDP-DGRLLVADHG-RGLVRFDPADGEVTVLA-DEYGKP 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  557 RA----IALHPmEGTIYWTDWGNTP------RIEAssmDGSGRRIIADthLFWPNGLTIDYAGRRMYWVDAKHHVIERAN 626
Cdd:COG3386    92 LNrpndGVVDP-DGRLYFTDMGEYLptgalyRVDP---DGSLRVLADG--LTFPNGIAFSPDGRTLYVADTGAGRIYRFD 165


                  ....
gi 224994223  627 LDGS 630
Cdd:COG3386   166 LDAD 169
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 852-894 1.32e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 1.32e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224994223    852 VLIWENLDRPRDIVVEPMGGYMYWTDWGaSPKIERAGMDASSR 894
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 460-502 1.61e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.44  E-value: 1.61e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224994223    460 YTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNV 502
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1085-1115 1.90e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.06  E-value: 1.90e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 224994223   1085 AIGVDPLEGKVYWSDSTLHRISRASLDGSQH 1115
Cdd:smart00135   13 GLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
395-434 1.93e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.93e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 224994223    395 DVNECAEEGYCSQG--CTNTEGAFQCWCEAGYElrpDRRSCK 434
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYT---DGRNCE 39
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1087-1242 2.01e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 51.52  E-value: 2.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1087 GVDPLEGKVYWSDSTLHRISRASLDGSQ-----HEDIITTGLQTTDGLAVDAiGRKVYWTDTGTNRIEVGNLDGSMRKVL 1161
Cdd:cd14963    14 GVAVSDGRIYVADTNNHRVQVFDYEGKFkksfgGPGTGPGEFKYPYGIAVDS-DGNIYVADLYNGRIQVFDPDGKFLKYF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1162 VWQ----NLDSPRAIVLYHemGFMYWTDWGENA--------KLERS-GMDGSDRtvlinNNLGWPNGLTVDKtSSQLLWA 1228
Cdd:cd14963    93 PEKkdrvKLISPAGLAIDD--GKLYVSDVKKHKvivfdlegKLLLEfGKPGSEP-----GELSYPNGIAVDE-DGNIYVA 164

                         170
                  ....*....|....
gi 224994223 1229 DAHTERIEVADLNG 1242
Cdd:cd14963   165 DSGNGRIQVFDKNG 178
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 471-688 2.22e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 51.17  E-value: 2.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  471 IALDFHHRrelVFWSDVTLDRILRANLNGSNVEEVVSTG-----LESPGGLAVDwVHDKLYWTDSGTSRIEVANLDGAHR 545
Cdd:cd05819    13 IAVDSSGN---IYVADTGNNRIQVFDPDGNFITSFGSFGsgdgqFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  546 KVLL-----WQSLEKPRAIALHPmEGTIYWTDWGNTpRIEASSMDGSGRRII-----ADTHLFWPNGLTIDYAGrRMYWV 615
Cdd:cd05819    89 ASFGgsgdgDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVDSDG-NIYVA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  616 DAKHHVIERANLDGSHRKAVISQGLP-----HPFAITVFED-SLYWTDWHTKSInsaNKFTGKNQEIIRN--------KL 681
Cdd:cd05819   166 DTGNHRIQVFDPDGNFLTTFGSTGTGpgqfnYPTGIAVDSDgNIYVADSGNNRV---QVFDPDGAGFGGNgnflgsdgQF 242


                  ....*..
gi 224994223  682 HFPMDIH 688
Cdd:cd05819   243 NRPSGLA 249
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 511-631 3.22e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 50.74  E-value: 3.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  511 ESPGGLAVDWVHDkLYWTDSGTSRIEVANLDGAHRKVlLWQS------LEKPRAIALHPmEGTIYWTD-WGNtpRIEASS 583
Cdd:cd14956    13 KDPRGIAVDADDN-VYVADARNGRIQVFDKDGTFLRR-FGTTgdgpgqFGRPRGLAVDK-DGWLYVADyWGD--RIQVFT 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 224994223  584 MDGSGRRII-----ADTHLFWPNGLTIDYAGRrmYWV-DAKHHVIERANLDGSH 631
Cdd:cd14956    88 LTGELQTIGgssgsGPGQFNAPRGVAVDADGN--LYVaDFGNQRIQKFDPDGSF 139
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1374-1583 4.91e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.08  E-value: 4.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1374 HTDVHVPVPGLNNVISLDYDSVHGKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTDGLAVDWVA-----RNLYWTDTG 1448
Cdd:COG3391     9 VAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADagadgRRLYVANSG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1449 RNTIeaSRLDGSCRKVLINNSL-DEPRAIAVFPRKGYLFWTDW--GHIAKIeranlDGSERKVLINTDLG-WPNGLTLDY 1524
Cdd:COG3391    89 SGRV--SVIDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSgnGRVSVI-----DTATGKVVATIPVGaGPHGIAVDP 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 224994223 1525 DTRRIYWVDAHLDRIeSA-----DL-NGK-LRQVLVSHVSHPFALTQQDRWIY-------WTDWQTKSIQRVD 1583
Cdd:COG3391   162 DGKRLYVANSGSNTV-SVivsviDTaTGKvVATIPVGGGPVGVAVSPDGRRLYvanrgsnTSNGGSNTVSVID 233
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1079-1155 5.98e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 49.89  E-value: 5.98e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 224994223 1079 TMKNTIAIGVDPlEGKVYWSDSTLHRISRASLDGsQHEDIITTGLQTTD--GLAVDAIGRKVYWTDTGTNRIEVGNLDG 1155
Cdd:cd14962    55 RFVSPIGVAIDA-NGNLYVSDAELGKVFVFDRDG-KFLRAIGAGALFKRptGIAVDPAGKRLYVVDTLAHKVKVFDLDG 131
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 377-398 7.79e-06

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 43.94  E-value: 7.79e-06
                           10        20
                   ....*....|....*....|..
gi 224994223   377 QCTCHTGYRLTEDGRTCQDVNE 398
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 482-616 8.94e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 49.60  E-value: 8.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  482 VFWSDVTLDRILRANLNGSNVEEVVSTG-----LESPGGLAVDwVHDKLYWTDSGTSRIEVANLDGAHRKVL-----LWQ 551
Cdd:cd14963   114 LYVSDVKKHKVIVFDLEGKLLLEFGKPGsepgeLSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKELngspdGKS 192

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 224994223  552 SLEKPRAIALHPmEGTIYWTDwgN-TPRIEASSMDG-----SGRRIIADTHLFWPNGLTIDYAGrRMYWVD 616
Cdd:cd14963   193 GFVNPRGIAVDP-DGNLYVVD--NlSHRVYVFDEQGkelftFGGRGKDDGQFNLPNGLFIDDDG-RLYVTD 259
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1379-1418 1.41e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.74  E-value: 1.41e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 224994223   1379 VPVPGLNNVISLDYDSVHGKVYYTDVFLDVIRRADLNGSN 1418
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 766-806 1.56e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.74  E-value: 1.56e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 224994223    766 VIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTG 806
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 774-969 1.92e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 48.47  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  774 SAVALDwdsRDDHVYWTDV--------STDTISRAKWDGTGQEvvvDTSLESPAGLAIDwVTNKLYWTDAGTDRIEVANT 845
Cdd:cd05819    58 AGVAVD---SDGNLYVADTgnhriqkfDPDGNFLASFGGSGDG---DGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  846 DGSMRTVL-----IWENLDRPRDIVVEPmGGYMYWTDWGASpKIERagMDASSRQV-------IISSNLTWPNGLAIDyG 913
Cdd:cd05819   131 DGEFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTGNH-RIQV--FDPDGNFLttfgstgTGPGQFNYPTGIAVD-S 205

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 224994223  914 SQRLYWADAGMK-----TIEFAGLDGSKRKVLIGSQLPHPFGLTL--YGqRIYWTDWQTKSIQ 969
Cdd:cd05819   206 DGNIYVADSGNNrvqvfDPDGAGFGGNGNFLGSDGQFNRPSGLAVdsDG-NLYVADTGNNRIQ 267
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 775-922 1.96e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 48.43  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  775 AVALDwdsRDDHVYWTDVSTDTIS--------RAKWDGTGQEvvvDTSLESPAGLAIDwVTNKLYWTDAGTDRIEVANTD 846
Cdd:cd14956    17 GIAVD---ADDNVYVADARNGRIQvfdkdgtfLRRFGTTGDG---PGQFGRPRGLAVD-KDGWLYVADYWGDRIQVFTLT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  847 GSMRTvlIWEN-------LDRPRDIVVEPmGGYMYWTDWGaSPKIERAGMDASsrqvIISS---------NLTWPNGLAI 910
Cdd:cd14956    90 GELQT--IGGSsgsgpgqFNAPRGVAVDA-DGNLYVADFG-NQRIQKFDPDGS----FLRQwggtgiepgSFNYPRGVAV 161

                         170
                  ....*....|..
gi 224994223  911 DyGSQRLYWADA 922
Cdd:cd14956   162 D-PDGTLYVADT 172
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 395-427 2.07e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.07e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224994223  395 DVNECAEEGYCSQG--CTNTEGAFQCWCEAGYELR 427
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYTGR 35
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1086-1283 2.63e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 48.08  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1086 IGVDPlEGKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTD-----GLAVDAIGRkVYWTDTGTNRIEVGNLDGsmRKV 1160
Cdd:cd05819    13 IAVDS-SGNIYVADTGNNRIQVFDPDGNFITSFGSFGSGDGQfnepaGVAVDSDGN-LYVADTGNHRIQKFDPDG--NFL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1161 LVW-------QNLDSPRAIVLyHEMGFMYWTDWGeNAKLERSGMDGSDRTVLINNNLGW-----PNGLTVDktSSQLLW- 1227
Cdd:cd05819    89 ASFggsgdgdGEFNGPRGIAV-DSSGNIYVADTG-NHRIQKFDPDGEFLTTFGSGGSGPgqfngPTGVAVD--SDGNIYv 164

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 224994223 1228 ADAHTERIEVADLNGA------NRHTLVSPVQHPYGLTlLDS--YIYWTDWQTRSIHRADKSTG 1283
Cdd:cd05819   165 ADTGNHRIQVFDPDGNflttfgSTGTGPGQFNYPTGIA-VDSdgNIYVADSGNNRVQVFDPDGA 227
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 785-825 2.74e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.92  E-value: 2.74e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223   785 DHVYWTDVSTD-TISRAKWDGTGQEVVVDTSLESPAGLAIDW 825
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1617-1648 3.01e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 3.01e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224994223  1617 CGVNNGGCTHLCFARASDFVCACPD----EPDGHPC 1648
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEgyelQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 938-979 4.07e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.59  E-value: 4.07e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 224994223    938 KVLIGSQLPHPFGLTL--YGQRIYWTDWQTKSIQSADrLTGLDR 979
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVAN-LDGTNR 43
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 774-969 4.26e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 47.31  E-value: 4.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  774 SAVALDwdsRDDHVYWTDVSTDTISraKWDGTGQEVVV-------DTSLESPAGLAIDwVTNKLYWTDAGTDRIEVANTD 846
Cdd:cd05819    11 QGIAVD---SSGNIYVADTGNNRIQ--VFDPDGNFITSfgsfgsgDGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  847 GSMRTVLI-----WENLDRPRDIVVEPMgGYMYWTDWGAspkieragmdasSRQVIISSN----LTW------------P 905
Cdd:cd05819    85 GNFLASFGgsgdgDGEFNGPRGIAVDSS-GNIYVADTGN------------HRIQKFDPDgeflTTFgsggsgpgqfngP 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 224994223  906 NGLAIDyGSQRLYWADAGMKTI-------EFAGLDGSkrKVLIGSQLPHPFGLTLYGQ-RIYWTDWQTKSIQ 969
Cdd:cd05819   152 TGVAVD-SDGNIYVADTGNHRIqvfdpdgNFLTTFGS--TGTGPGQFNYPTGIAVDSDgNIYVADSGNNRVQ 220
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 766-923 5.15e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 46.82  E-value: 5.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  766 VIPLADVRSA--VALDwdsRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNkLYWTDAGTDRIEVA 843
Cdd:cd14952     3 VLPFTGLDGPggVAVD---AAGNVYVADSGNNRVLKLAAGSTTQTVLPFTGLYQPQGVAVDAAGT-VYVTDFGNNRVLKL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  844 NTDGSMRTVLIWENLDRPRDIVVEPmGGYMYWTDWGASPKIERAGmdASSRQVIIS-SNLTWPNGLAIDyGSQRLYWADA 922
Cdd:cd14952    79 AAGSTTQTVLPFTGLNDPTGVAVDA-AGNVYVADTGNNRVLKLAA--GSNTQTVLPfTGLSNPDGVAVD-GAGNVYVTDT 154


                  .
gi 224994223  923 G 923
Cdd:cd14952   155 G 155
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 915-954 7.03e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.76  E-value: 7.03e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 224994223   915 QRLYWADAGMK-TIEFAGLDGSKRKVLIGSQLPHPFGLTLY 954
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVD 41
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1093-1245 7.68e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 46.43  E-value: 7.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1093 GKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTDGLAVDAiGRKVYWTDTGTNRieVGNLDG--SMRKVLVWQNLDSPR 1170
Cdd:cd14952    63 GTVYVTDFGNNRVLKLAAGSTTQTVLPFTGLNDPTGVAVDA-AGNVYVADTGNNR--VLKLAAgsNTQTVLPFTGLSNPD 139

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 224994223 1171 AIVLyHEMGFMYWTDWGEN--AKLErSGmdGSDRTVLINNNLGWPNGLTVDKTSSqllwadahterIEVADLNGaNR 1245
Cdd:cd14952   140 GVAV-DGAGNVYVTDTGNNrvLKLA-AG--STTQTVLPFTGLNSPSGVAVDTAGN-----------VYVTDHGN-NR 200
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1093-1132 8.23e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.38  E-value: 8.23e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223  1093 GKVYWSDSTLH-RISRASLDGSqHEDIITTG-LQTTDGLAVD 1132
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGS-DRKTLFTDdLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1159-1202 8.60e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 8.60e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 224994223   1159 KVLVWQNLDSPRAIVLYHEMGFMYWTDWGeNAKLERSGMDGSDR 1202
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 633-673 1.09e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.05  E-value: 1.09e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224994223    633 KAVISQGLPHP--FAITVFEDSLYWTDWHTKSINSANkFTGKN 673
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN-LDGTN 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 956-996 1.47e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.99  E-value: 1.47e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223   956 QRIYWTDWQTKSIQSADRLTGLDRETL-QENLENLMDIHVFH 996
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLfTDDLQHPNAIAVDP 42
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1031-1275 2.21e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 44.97  E-value: 2.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1031 PTGINLLRDGKtcspgmnsflIFA-----RRIDVrmVSLD---IPYFADVVVPINMTMknTIAIGVDplEGKVYWSDSTL 1102
Cdd:cd14963    58 PYGIAVDSDGN----------IYVadlynGRIQV--FDPDgkfLKYFPEKKDRVKLIS--PAGLAID--DGKLYVSDVKK 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1103 HRISRASLDGSQHEDIITTG-----LQTTDGLAVDAIGRkVYWTDTGTNRIEVGNLDGSmrkvlvwqnldspraivlyhe 1177
Cdd:cd14963   122 HKVIVFDLEGKLLLEFGKPGsepgeLSYPNGIAVDEDGN-IYVADSGNGRIQVFDKNGK--------------------- 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1178 mgFMYWtdwgenaklersgMDGSDrtvLINNNLGWPNGLTVDKTsSQLLWADAHTERIEVADLNGANRHTLVSPVQ---- 1253
Cdd:cd14963   180 --FIKE-------------LNGSP---DGKSGFVNPRGIAVDPD-GNLYVVDNLSHRVYVFDEQGKELFTFGGRGKddgq 240

                         250       260
                  ....*....|....*....|....*
gi 224994223 1254 --HPYGLTLLDS-YIYWTDWQTRSI 1275
Cdd:cd14963   241 fnLPNGLFIDDDgRLYVTDRENNRV 265
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 399-433 2.37e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.92  E-value: 2.37e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224994223   399 CAEE-GYCSQGCTNTEGAFQCWCEAGYELRPDRRSC 433
Cdd:pfam14670    1 CSVNnGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 780-921 2.75e-04

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 44.56  E-value: 2.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223   780 WDSRDDHVYWTDVSTDTISRAkWDGTGQEVVVDTSleSPAGLAIDWVTNKLYWTDAgtDRIEVANTDGSMRTVLIWENLD 859
Cdd:pfam08450    7 WDEEEGALYWVDILGGRIHRL-DPATGKETVWDTP--GPVGAIAPRDDGGLIVALK--DGVALLDLATGELTPLADPEDD 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 224994223   860 -----RPRDIVVEPMGGYmywtdWGASPKIERAGM---------DASSRQVIISSNLTWPNGLAIDYGSQRLYWAD 921
Cdd:pfam08450   82 dwplnRFNDGKVDPDGRF-----WFGTMGDDEAPGgdpgalyrlDPDGKLTRVLDGLTISNGLAWSPDGRTLYFAD 152
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1080-1243 4.74e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 44.20  E-value: 4.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1080 MKNTIAIGVDPlEGKVYWSDSTLHRISRASLDGSQHEDIITTG-----LQTTDGLAVDAIGRkVYWTDTGTNRIEVGNLD 1154
Cdd:cd14956    12 FKDPRGIAVDA-DDNVYVADARNGRIQVFDKDGTFLRRFGTTGdgpgqFGRPRGLAVDKDGW-LYVADYWGDRIQVFTLT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1155 GSmrkvlvWQNL-----------DSPRAIVLYHEmGFMYWTDWGeNAKLERSGMDGSdrTVLINNNLG-------WPNGL 1216
Cdd:cd14956    90 GE------LQTIggssgsgpgqfNAPRGVAVDAD-GNLYVADFG-NQRIQKFDPDGS--FLRQWGGTGiepgsfnYPRGV 159

                         170       180
                  ....*....|....*....|....*...
gi 224994223 1217 TVDktSSQLLW-ADAHTERIEVADLNGA 1243
Cdd:cd14956   160 AVD--PDGTLYvADTYNDRIQVFDNDGA 185
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1069-1148 6.02e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 43.74  E-value: 6.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1069 FADVVVPInmtmkntiAIGVDPlEGKVYWSDSTLHRISRasLDGSQHEDIIT--TGLQTTDGLAVDAIGrKVYWTDTGTN 1146
Cdd:cd14952   174 FTGLNSPS--------GVAVDT-AGNVYVTDHGNNRVLK--LAAGSTTPTVLpfTGLNGPLGVAVDAAG-NVYVADRGND 241


                  ..
gi 224994223 1147 RI 1148
Cdd:cd14952   242 RV 243
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1088-1221 6.65e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 43.35  E-value: 6.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1088 VDPlEGKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTDGLAVDAIGrKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLD 1167
Cdd:cd14952   101 VDA-AGNVYVADTGNNRVLKLAAGSNTQTVLPFTGLSNPDGVAVDGAG-NVYVTDTGNNRVLKLAAGSTTQTVLPFTGLN 178

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 224994223 1168 SPRAIVLYHEmGFMYWTDWGENAKLE-RSGMDGSdrTVLINNNLGWPNGLTVDKT 1221
Cdd:cd14952   179 SPSGVAVDTA-GNVYVTDHGNNRVLKlAAGSTTP--TVLPFTGLNGPLGVAVDAA 230
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 480-520 6.89e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.07  E-value: 6.89e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223   480 ELVFWSDVTLD-RILRANLNGSNVEEVVSTGLESPGGLAVDW 520
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1432-1548 8.63e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 43.34  E-value: 8.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1432 GLAVDWVARnLYWTDTGRNTIeaSRLDGSCRKV-LINNSLDE----PRAIAVFPrKGYLFWTDWGHiAKIERANLDGSER 1506
Cdd:cd14962    16 GVAADGRGR-IYVADTGRGAV--FVFDLPNGKVfVIGNAGPNrfvsPIGVAIDA-NGNLYVSDAEL-GKVFVFDRDGKFL 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 224994223 1507 KVlINTDLGW--PNGLTLDYDTRRIYWVDAHLDRIESADLNGKL 1548
Cdd:cd14962    91 RA-IGAGALFkrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRL 133
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1245-1286 9.85e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 9.85e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 224994223   1245 RHTLVSPVQHPYGLTL--LDSYIYWTDWQTRSIHRADKsTGSNV 1286
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVANL-DGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1549-1589 1.09e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 1.09e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224994223   1549 RQVLVSHVSHP--FALTQQDRWIYWTDWQTKSIQRVDkYSGRN 1589
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN-LDGTN 42
EGF_CA pfam07645
Calcium-binding EGF domain;
395-423 1.26e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.26e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 224994223   395 DVNECAEEGY-CSQG--CTNTEGAFQCWCEAG 423
Cdd:pfam07645    1 DVDECATGTHnCPANtvCVNTIGSFECRCPDG 32
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1397-1583 1.76e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 42.19  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1397 GKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTdGLAVDWvARNLYWTDTGRNTIEASRLDGSCRKVLinNSLDEPRAI 1476
Cdd:COG3386    19 GRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGRPN-GLAFDP-DGRLLVADHGRGLVRFDPADGEVTVLA--DEYGKPLNR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1477 ---AVFPRKGYLFWTD---WGHIAKIERANLDGSERKVLinTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADL--NGKL 1548
Cdd:COG3386    95 pndGVVDPDGRLYFTDmgeYLPTGALYRVDPDGSLRVLA--DGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLdaDGTL 172

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 224994223 1549 --RQVLVSHVSHP-----FALTQQDRwIYWTDWQTKSIQRVD 1583
Cdd:COG3386   173 gnRRVFADLPDGPggpdgLAVDADGN-LWVALWGGGGVVRFD 213
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 509-651 1.88e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 42.28  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  509 GLESPGGLAVDWvhDKLYWTDSGTSRIEVANLDGAHRKVLLWQSLEK-----PRAIALHPmEGTIYWTDWGNTpRIEASS 583
Cdd:cd14963     8 PLNKPMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGPGTGPgefkyPYGIAVDS-DGNIYVADLYNG-RIQVFD 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 224994223  584 MDGSGRRIIADT----HLFWPNGLTIDyaGRRMYWVDAKHHVIERANLDGSHRKAVISQG-----LPHPFAITVFED 651
Cdd:cd14963    84 PDGKFLKYFPEKkdrvKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLEFGKPGsepgeLSYPNGIAVDED 158
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1397-1437 2.22e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.52  E-value: 2.22e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994223  1397 GKVYYTDVFLD-VIRRADLNGSNMETVIGHGLKTTDGLAVDW 1437
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 482-575 2.78e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.42  E-value: 2.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  482 VFWSDVTLDRILRANLnGSNVEEVVS-TGLESPGGLAVDWVHDkLYWTDSGTSRieVANLD-GAH-RKVLLWQSLEKPRA 558
Cdd:cd14952   149 VYVTDTGNNRVLKLAA-GSTTQTVLPfTGLNSPSGVAVDTAGN-VYVTDHGNNR--VLKLAaGSTtPTVLPFTGLNGPLG 224

                          90
                  ....*....|....*..
gi 224994223  559 IALHPMeGTIYWTDWGN 575
Cdd:cd14952   225 VAVDAA-GNVYVADRGN 240
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 390-432 3.55e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 41.22  E-value: 3.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 224994223  390 GRTCQDVNECAEEGY-CSQGCTNTEGAFQCWCEAGYELRPDRRS 432
Cdd:cd01475   181 GKICVVPDLCATLSHvCQQVCISTPGSYLCACTEGYALLEDNKT 224
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 766-923 5.34e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 40.65  E-value: 5.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  766 VIPLADVRS--AVALDwdsRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNkLYWTDAGTDRIEVA 843
Cdd:cd14952    87 VLPFTGLNDptGVAVD---AAGNVYVADTGNNRVLKLAAGSNTQTVLPFTGLSNPDGVAVDGAGN-VYVTDTGNNRVLKL 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223  844 NTDGSMRTVLIWENLDRPRDIVVEPMGGyMYWTDWGASPKIE-RAGMDASSrqVIISSNLTWPNGLAIDyGSQRLYWADA 922
Cdd:cd14952   163 AAGSTTQTVLPFTGLNSPSGVAVDTAGN-VYVTDHGNNRVLKlAAGSTTPT--VLPFTGLNGPLGVAVD-AAGNVYVADR 238


                  .
gi 224994223  923 G 923
Cdd:cd14952   239 G 239
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1527-1563 5.44e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 36.37  E-value: 5.44e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 224994223  1527 RRIYWVDAHLD-RIESADLNGKLRQVLVSH-VSHPFALT 1563
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDdLQHPNAIA 39
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1441-1587 5.71e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 40.77  E-value: 5.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1441 NLYWTDTGRNTIeaSRLDGSCRKV--LINNSLDEPRAIAVFPRkGYLFWTDW--GHIAKIERAnlDGSERKVLINTDLGW 1516
Cdd:COG4257    29 AVWFTDQGGGRI--GRLDPATGEFteYPLGGGSGPHGIAVDPD-GNLWFTDNgnNRIGRIDPK--TGEITTFALPGGGSN 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 224994223 1517 PNGLTLDYDtRRIYWVDAHLDRIesADLNGKLRQVLVSHV----SHPFALT-QQDRWIYWTDWQTKSIQRVDKYSG 1587
Cdd:COG4257   104 PHGIAFDPD-GNLWFTDQGGNRI--GRLDPATGEVTEFPLptggAGPYGIAvDPDGNLWVTDFGANAIGRIDPDTG 176
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1388-1559 6.48e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 40.65  E-value: 6.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1388 ISLDYDSvHGKVYYTDVFLDVIRRADLNGsNMETVIGHGLKTTD--GLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVL 1465
Cdd:cd14962    60 IGVAIDA-NGNLYVSDAELGKVFVFDRDG-KFLRAIGAGALFKRptGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDI 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1466 -----INNSLDEPRAIAVfPRKGYLFWTDWGHiAKIERANLDGSERKVL--INTDLGW---PNGLTLDYDTRrIYWVDAH 1535
Cdd:cd14962   138 gkrgsGPGEFNLPTDLAV-DRDGNLYVTDTMN-FRVQIFDADGKFLRSFgeRGDGPGSfarPKGIAVDSEGN-IYVVDAA 214

                         170       180
                  ....*....|....*....|....
gi 224994223 1536 LDRIESADLNGKLRQVLVSHVSHP 1559
Cdd:cd14962   215 FDNVQIFNPEGELLLTVGGPGSGP 238
EGF smart00181
Epidermal growth factor-like domain;
398-429 7.67e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.96  E-value: 7.67e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 224994223    398 ECAEEGYCSQG-CTNTEGAFQCWCEAGYELRPD 429
Cdd:smart00181    1 ECASGGPCSNGtCINTPGSYTCSCPPGYTGDKR 33
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1088-1148 7.85e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 40.26  E-value: 7.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 224994223 1088 VDPlEGKVYWSDSTLH----RISRASLDGSQHedIITTGLQTTDGLAVDAIGRKVYWTDTGTNRI 1148
Cdd:COG3386   100 VDP-DGRLYFTDMGEYlptgALYRVDPDGSLR--VLADGLTFPNGIAFSPDGRTLYVADTGAGRI 161
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1128-1283 9.47e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 40.00  E-value: 9.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1128 GLAVDAIGRkVYWTDTGTNRIEVGNL-DGSMRKVlVWQNLDSPRAIVLYHEmGFMYWTDWGENA--KLERSgmDGSDRTV 1204
Cdd:COG4257    21 DVAVDPDGA-VWFTDQGGGRIGRLDPaTGEFTEY-PLGGGSGPHGIAVDPD-GNLWFTDNGNNRigRIDPK--TGEITTF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994223 1205 LINNNLGWPNGLTVDktSSQLLW-ADAHTERIevADLNGANRHTLV--SPVQH--PYGLTL-LDSYIYWTDWQTRSIHRA 1278
Cdd:COG4257    96 ALPGGGSNPHGIAFD--PDGNLWfTDQGGNRI--GRLDPATGEVTEfpLPTGGagPYGIAVdPDGNLWVTDFGANAIGRI 171


                  ....*
gi 224994223 1279 DKSTG 1283
Cdd:COG4257   172 DPDTG 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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