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Conserved domains on  [gi|114431250|ref|NP_766283|]
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phospholipase A-2-activating protein isoform 1 [Mus musculus]

Protein Classification

WD repeat PLAP family protein( domain architecture ID 10078051)

WD repeat PLAP family protein containing WD40, PFU, and PUL domains, similar to vertebrate phospholipase A-2-activating protein (PLAP or PLAA), a ubiquitin-binding protein involved in protein ubiquitination, sorting and degradation

CATH:  2.130.10.10
Gene Ontology:  GO:0005515|GO:0043130
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PUL pfam08324
PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated ...
 536-788 1.20e-83

PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.


:

Pssm-ID: 462428  Cd Length: 261  Bit Score: 267.28  E-value: 1.20e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  536 PKKEALTFDQANPTQILGKLKELNGTAPEEKKLTEDDLVLLEKILSLICNNSSEKptAQQLQILWKAI-NWPEDIVFPAL 614
Cdd:pfam08324   1 PQKTYLSFKKANLDKILKKLGEFNGGEPKVLALSPEELATLEALLSFLESSSSAS--EADIELLLKILtSWPPEDRFPAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  615 DILRLSIKHPNVNENFCNEKGDQFSSHLINLLNPKGKPANQLLALRTFCNCFVSQAGQKLMMSQRESLMSHAIELKSGS- 693
Cdd:pfam08324  79 DLLRLLALDPRVAAYFAEEEGGKTISTLLSLLISSGLYALRMLALRLLCNLFSSPLGRQLLLSHFDSILSTLASLLSSSl 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  694 ---NKNIHIALATLTLNYSVCFHK---DHNIEGKAQCLSVISTILEVVQ-DLEATFRLLVALGTLI--SDDSNAIQLAKS 764
Cdd:pfam08324 159 ldsNKNLRIALATLLLNYAVLLHKeksPLSEEDQVELLAALLEALSTEEeDSEALYRLLVALGTLVyaPDGEVLADLAQV 238

                         250       260
                  ....*....|....*....|....
gi 114431250  765 LGVDSQIKKYVSVSEPaKVSECCR 788
Cdd:pfam08324 239 LDAASWVKKAKKKKEP-RIKEVGS 261
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-297 1.20e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 209.50  E-value: 1.20e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  10 LSCSLPGHELDVRGlVCCLYPPGAFVSVSRDRTTRLWapDSPNRgfTEMHCMSGHSNFVSCVCIIPSSDiyphgLIATGG 89
Cdd:cd00200    1 LRRTLKGHTGGVTC-VAFSPDGKLLATGSGDGTIKVW--DLETG--ELLRTLKGHTGPVRDVAASADGT-----YLASGS 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  90 NDHNICIFSLDSPMPLYILKGHKDTVCSLS-SGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLM 166
Cdd:cd00200   71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAfSPDGRILSSSSRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250 167 LTGSADKTIKLW--KAGRCERTFLGHEDCVRGLAIL-SETEFLSCANDASIRRWQI-TGECLEVYFGHTNYIYSISVFPN 242
Cdd:cd00200  151 ASSSQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLsTGKCLGTLRGHENGVNSVAFSPD 230

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 114431250 243 SKDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCVLENG-DIVVGASDGIIRVF 297
Cdd:cd00200  231 GYLLASGSEDGTIRVWdlRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIW 288
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 346-459 2.20e-58

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


:

Pssm-ID: 462670  Cd Length: 111  Bit Score: 193.89  E-value: 2.20e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  346 PGTREGQTRLIRDGE-RVEAYQWSVSDGRWIKIGDVVGSSGanqqTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNVSD 424
Cdd:pfam09070   1 PGKKEGQVKMVREGNgVVEAYQWSAAEQQWEKIGDVVGSAG----SSQKKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGD 76

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 114431250  425 DPWLVAYNFLQKNDLNPMFLDQVAKFIIDNTKGQT 459
Cdd:pfam09070  77 NPYEAAQKFLARNELPQSYLDQVVNFIIKNTGGVT 111
 
Name Accession Description Interval E-value
PUL pfam08324
PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated ...
 536-788 1.20e-83

PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.


Pssm-ID: 462428  Cd Length: 261  Bit Score: 267.28  E-value: 1.20e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  536 PKKEALTFDQANPTQILGKLKELNGTAPEEKKLTEDDLVLLEKILSLICNNSSEKptAQQLQILWKAI-NWPEDIVFPAL 614
Cdd:pfam08324   1 PQKTYLSFKKANLDKILKKLGEFNGGEPKVLALSPEELATLEALLSFLESSSSAS--EADIELLLKILtSWPPEDRFPAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  615 DILRLSIKHPNVNENFCNEKGDQFSSHLINLLNPKGKPANQLLALRTFCNCFVSQAGQKLMMSQRESLMSHAIELKSGS- 693
Cdd:pfam08324  79 DLLRLLALDPRVAAYFAEEEGGKTISTLLSLLISSGLYALRMLALRLLCNLFSSPLGRQLLLSHFDSILSTLASLLSSSl 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  694 ---NKNIHIALATLTLNYSVCFHK---DHNIEGKAQCLSVISTILEVVQ-DLEATFRLLVALGTLI--SDDSNAIQLAKS 764
Cdd:pfam08324 159 ldsNKNLRIALATLLLNYAVLLHKeksPLSEEDQVELLAALLEALSTEEeDSEALYRLLVALGTLVyaPDGEVLADLAQV 238

                         250       260
                  ....*....|....*....|....
gi 114431250  765 LGVDSQIKKYVSVSEPaKVSECCR 788
Cdd:pfam08324 239 LDAASWVKKAKKKKEP-RIKEVGS 261
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-297 1.20e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 209.50  E-value: 1.20e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  10 LSCSLPGHELDVRGlVCCLYPPGAFVSVSRDRTTRLWapDSPNRgfTEMHCMSGHSNFVSCVCIIPSSDiyphgLIATGG 89
Cdd:cd00200    1 LRRTLKGHTGGVTC-VAFSPDGKLLATGSGDGTIKVW--DLETG--ELLRTLKGHTGPVRDVAASADGT-----YLASGS 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  90 NDHNICIFSLDSPMPLYILKGHKDTVCSLS-SGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLM 166
Cdd:cd00200   71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAfSPDGRILSSSSRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250 167 LTGSADKTIKLW--KAGRCERTFLGHEDCVRGLAIL-SETEFLSCANDASIRRWQI-TGECLEVYFGHTNYIYSISVFPN 242
Cdd:cd00200  151 ASSSQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLsTGKCLGTLRGHENGVNSVAFSPD 230

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 114431250 243 SKDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCVLENG-DIVVGASDGIIRVF 297
Cdd:cd00200  231 GYLLASGSEDGTIRVWdlRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIW 288
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 346-459 2.20e-58

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


Pssm-ID: 462670  Cd Length: 111  Bit Score: 193.89  E-value: 2.20e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  346 PGTREGQTRLIRDGE-RVEAYQWSVSDGRWIKIGDVVGSSGanqqTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNVSD 424
Cdd:pfam09070   1 PGKKEGQVKMVREGNgVVEAYQWSAAEQQWEKIGDVVGSAG----SSQKKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGD 76

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 114431250  425 DPWLVAYNFLQKNDLNPMFLDQVAKFIIDNTKGQT 459
Cdd:pfam09070  77 NPYEAAQKFLARNELPQSYLDQVVNFIIKNTGGVT 111
WD40 COG2319
WD40 repeat [General function prediction only];
13-296 2.38e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.56  E-value: 2.38e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  13 SLPGHELDVRGLVCcLYPPGAFVSVSRDRTTRLWAPDSPNRGFTemhcMSGHSNFVSCVCIIPSSDIyphglIATGGNDH 92
Cdd:COG2319   73 TLLGHTAAVLSVAF-SPDGRLLASASADGTVRLWDLATGLLLRT----LTGHTGAVRSVAFSPDGKT-----LASGSADG 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  93 NICIFSLDSPMPLYILKGHKDTVCSLS---SGKfgTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLML 167
Cdd:COG2319  143 TVRLWDLATGKLLRTLTGHSGAVTSVAfspDGK--LLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250 168 TGSADKTIKLW--KAGRCERTFLGHEDCVRGLAILSETEFL-SCANDASIRRWQI-TGECLEVYFGHTNYIYSISVFPNS 243
Cdd:COG2319  221 SGSADGTVRLWdlATGKLLRTLTGHSGSVRSVAFSPDGRLLaSGSADGTVRLWDLaTGELLRTLTGHSGGVNSVAFSPDG 300

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 114431250 244 KDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCVLENGD-IVVGASDGIIRV 296
Cdd:COG2319  301 KLLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGKtLASGSDDGTVRL 356
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-179 9.41e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 9.41e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 114431250   142 KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTIKLWK 179
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
142-178 2.05e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 2.05e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 114431250  142 KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTIKLW 178
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 6-170 4.38e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 4.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250   6 SRYRLSCSLPGHELDVRGLVCCLYPPGAFVSVSRDRTTRLWapdSPNRGFTeMHCMSGHSNFvsCVCIIPSSDIYPhglI 85
Cdd:PLN00181 563 ARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLW---SINQGVS-IGTIKTKANI--CCVQFPSESGRS---L 633

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  86 ATGGNDHNICIFSLDSP-MPLYILKGHKDTVCSLSSGKFGTLLSGSWDTTAKVW--------LNDKCMMTLQGHTAAVWA 156
Cdd:PLN00181 634 AFGSADHKVYYYDLRNPkLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsisgINETPLHSFMGHTNVKNF 713

                        170
                 ....*....|....
gi 114431250 157 VKILPEQGLMLTGS 170
Cdd:PLN00181 714 VGLSVSDGYIATGS 727
 
Name Accession Description Interval E-value
PUL pfam08324
PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated ...
 536-788 1.20e-83

PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.


Pssm-ID: 462428  Cd Length: 261  Bit Score: 267.28  E-value: 1.20e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  536 PKKEALTFDQANPTQILGKLKELNGTAPEEKKLTEDDLVLLEKILSLICNNSSEKptAQQLQILWKAI-NWPEDIVFPAL 614
Cdd:pfam08324   1 PQKTYLSFKKANLDKILKKLGEFNGGEPKVLALSPEELATLEALLSFLESSSSAS--EADIELLLKILtSWPPEDRFPAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  615 DILRLSIKHPNVNENFCNEKGDQFSSHLINLLNPKGKPANQLLALRTFCNCFVSQAGQKLMMSQRESLMSHAIELKSGS- 693
Cdd:pfam08324  79 DLLRLLALDPRVAAYFAEEEGGKTISTLLSLLISSGLYALRMLALRLLCNLFSSPLGRQLLLSHFDSILSTLASLLSSSl 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  694 ---NKNIHIALATLTLNYSVCFHK---DHNIEGKAQCLSVISTILEVVQ-DLEATFRLLVALGTLI--SDDSNAIQLAKS 764
Cdd:pfam08324 159 ldsNKNLRIALATLLLNYAVLLHKeksPLSEEDQVELLAALLEALSTEEeDSEALYRLLVALGTLVyaPDGEVLADLAQV 238

                         250       260
                  ....*....|....*....|....
gi 114431250  765 LGVDSQIKKYVSVSEPaKVSECCR 788
Cdd:pfam08324 239 LDAASWVKKAKKKKEP-RIKEVGS 261
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-297 1.20e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 209.50  E-value: 1.20e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  10 LSCSLPGHELDVRGlVCCLYPPGAFVSVSRDRTTRLWapDSPNRgfTEMHCMSGHSNFVSCVCIIPSSDiyphgLIATGG 89
Cdd:cd00200    1 LRRTLKGHTGGVTC-VAFSPDGKLLATGSGDGTIKVW--DLETG--ELLRTLKGHTGPVRDVAASADGT-----YLASGS 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  90 NDHNICIFSLDSPMPLYILKGHKDTVCSLS-SGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLM 166
Cdd:cd00200   71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAfSPDGRILSSSSRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250 167 LTGSADKTIKLW--KAGRCERTFLGHEDCVRGLAIL-SETEFLSCANDASIRRWQI-TGECLEVYFGHTNYIYSISVFPN 242
Cdd:cd00200  151 ASSSQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLsTGKCLGTLRGHENGVNSVAFSPD 230

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 114431250 243 SKDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCVLENG-DIVVGASDGIIRVF 297
Cdd:cd00200  231 GYLLASGSEDGTIRVWdlRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIW 288
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 346-459 2.20e-58

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


Pssm-ID: 462670  Cd Length: 111  Bit Score: 193.89  E-value: 2.20e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  346 PGTREGQTRLIRDGE-RVEAYQWSVSDGRWIKIGDVVGSSGanqqTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNVSD 424
Cdd:pfam09070   1 PGKKEGQVKMVREGNgVVEAYQWSAAEQQWEKIGDVVGSAG----SSQKKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGD 76

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 114431250  425 DPWLVAYNFLQKNDLNPMFLDQVAKFIIDNTKGQT 459
Cdd:pfam09070  77 NPYEAAQKFLARNELPQSYLDQVVNFIIKNTGGVT 111
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-259 4.93e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 182.92  E-value: 4.93e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250   9 RLSCSLPGHELDVRGLVCCLYPPgAFVSVSRDRTTRLWAPDSPNRGFTemhcMSGHSNFVSCVCIIPSSDIyphglIATG 88
Cdd:cd00200   42 ELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLETGECVRT----LTGHTSYVSSVAFSPDGRI-----LSSS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  89 GNDHNICIFSLDSPMPLYILKGHKDTVCSLSSGKFGTLL-SGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGL 165
Cdd:cd00200  112 SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVaSSSQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDGEK 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250 166 MLTGSADKTIKLW--KAGRCERTFLGHEDCVRGLAILSETEFL-SCANDASIRRWQI-TGECLEVYFGHTNYIYSISVFP 241
Cdd:cd00200  192 LLSSSSDGTIKLWdlSTGKCLGTLRGHENGVNSVAFSPDGYLLaSGSEDGTIRVWDLrTGECVQTLSGHTNSVTSLAWSP 271

                        250
                 ....*....|....*...
gi 114431250 242 NSKDFVTTAEDRSLRIWK 259
Cdd:cd00200  272 DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
13-296 2.38e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.56  E-value: 2.38e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  13 SLPGHELDVRGLVCcLYPPGAFVSVSRDRTTRLWAPDSPNRGFTemhcMSGHSNFVSCVCIIPSSDIyphglIATGGNDH 92
Cdd:COG2319   73 TLLGHTAAVLSVAF-SPDGRLLASASADGTVRLWDLATGLLLRT----LTGHTGAVRSVAFSPDGKT-----LASGSADG 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  93 NICIFSLDSPMPLYILKGHKDTVCSLS---SGKfgTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLML 167
Cdd:COG2319  143 TVRLWDLATGKLLRTLTGHSGAVTSVAfspDGK--LLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250 168 TGSADKTIKLW--KAGRCERTFLGHEDCVRGLAILSETEFL-SCANDASIRRWQI-TGECLEVYFGHTNYIYSISVFPNS 243
Cdd:COG2319  221 SGSADGTVRLWdlATGKLLRTLTGHSGSVRSVAFSPDGRLLaSGSADGTVRLWDLaTGELLRTLTGHSGGVNSVAFSPDG 300

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 114431250 244 KDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCVLENGD-IVVGASDGIIRV 296
Cdd:COG2319  301 KLLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGKtLASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
13-258 2.04e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.08  E-value: 2.04e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  13 SLPGHELDVRGLvcclyppgAF-------VSVSRDRTTRLWAPDSPNRGFTemhcMSGHSNFVSCVCIIPSSDiyphgLI 85
Cdd:COG2319  157 TLTGHSGAVTSV--------AFspdgkllASGSDDGTVRLWDLATGKLLRT----LTGHTGAVRSVAFSPDGK-----LL 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  86 ATGGNDHNICIFSLDSPMPLYILKGHKDTVCSLS---SGKfgTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKIL 160
Cdd:COG2319  220 ASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAfspDGR--LLASGSADGTVRLWdlATGELLRTLTGHSGGVNSVAFS 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250 161 PEQGLMLTGSADKTIKLWKA--GRCERTFLGHEDCVRGLAILSETEFL-SCANDASIRRWQI-TGECLEVYFGHTNYIYS 236
Cdd:COG2319  298 PDGKLLASGSDDGTVRLWDLatGKLLRTLTGHTGAVRSVAFSPDGKTLaSGSDDGTVRLWDLaTGELLRTLTGHTGAVTS 377

                        250       260
                 ....*....|....*....|..
gi 114431250 237 ISVFPNSKDFVTTAEDRSLRIW 258
Cdd:COG2319  378 VAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
9-180 9.68e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 9.68e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250   9 RLSCSLPGHELDVRGLvcclyppgAF-------VSVSRDRTTRLWAPDSPNRGFTemhcMSGHSNFVSCVCIIPSSDiyp 81
Cdd:COG2319  237 KLLRTLTGHSGSVRSV--------AFspdgrllASGSADGTVRLWDLATGELLRT----LTGHSGGVNSVAFSPDGK--- 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  82 hgLIATGGNDHNICIFSLDSPMPLYILKGHKDTVCSLS---SGKfgTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWA 156
Cdd:COG2319  302 --LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAfspDGK--TLASGSDDGTVRLWdlATGELLRTLTGHTGAVTS 377

                        170       180
                 ....*....|....*....|....
gi 114431250 157 VKILPEQGLMLTGSADKTIKLWKA 180
Cdd:COG2319  378 VAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
124-297 1.88e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.62  E-value: 1.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250 124 GTLLSGSWDTTAKVWLND--KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTIKLWKA--GRCERTFLGHEDCVRGLAI 199
Cdd:COG2319   49 ARLAAGAGDLTLLLLDAAagALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLatGLLLRTLTGHTGAVRSVAF 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250 200 LSETEFL-SCANDASIRRWQI-TGECLEVYFGHTNYIYSISVFPNSKDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIW 275
Cdd:COG2319  129 SPDGKTLaSGSADGTVRLWDLaTGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWdlATGKLLRTLTGHTGAVR 208

                        170       180
                 ....*....|....*....|...
gi 114431250 276 CCCVLENGD-IVVGASDGIIRVF 297
Cdd:COG2319  209 SVAFSPDGKlLASGSADGTVRLW 231
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-179 9.41e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 9.41e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 114431250   142 KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTIKLWK 179
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
142-178 2.05e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 2.05e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 114431250  142 KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTIKLW 178
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 220-259 2.59e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 2.59e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 114431250   220 TGECLEVYFGHTNYIYSISVFPNSKDFVTTAEDRSLRIWK 259
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
13-101 2.11e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 2.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  13 SLPGHELDVRGLVccLYPPGAF-VSVSRDRTTRLWAPDSPnrgfTEMHCMSGHSNFVSCVCIIPSSDiyphgLIATGGND 91
Cdd:COG2319  325 TLTGHTGAVRSVA--FSPDGKTlASGSDDGTVRLWDLATG----ELLRTLTGHTGAVTSVAFSPDGR-----TLASGSAD 393

                         90
                 ....*....|
gi 114431250  92 HNICIFSLDS 101
Cdd:COG2319  394 GTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 6-170 4.38e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 4.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250   6 SRYRLSCSLPGHELDVRGLVCCLYPPGAFVSVSRDRTTRLWapdSPNRGFTeMHCMSGHSNFvsCVCIIPSSDIYPhglI 85
Cdd:PLN00181 563 ARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLW---SINQGVS-IGTIKTKANI--CCVQFPSESGRS---L 633

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114431250  86 ATGGNDHNICIFSLDSP-MPLYILKGHKDTVCSLSSGKFGTLLSGSWDTTAKVW--------LNDKCMMTLQGHTAAVWA 156
Cdd:PLN00181 634 AFGSADHKVYYYDLRNPkLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsisgINETPLHSFMGHTNVKNF 713

                        170
                 ....*....|....
gi 114431250 157 VKILPEQGLMLTGS 170
Cdd:PLN00181 714 VGLSVSDGYIATGS 727
WD40 pfam00400
WD domain, G-beta repeat;
221-258 5.09e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 5.09e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 114431250  221 GECLEVYFGHTNYIYSISVFPNSKDFVTTAEDRSLRIW 258
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
104-138 1.70e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.70e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 114431250  104 PLYILKGHKDTVCSLSSGKFGTLL-SGSWDTTAKVW 138
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLaSGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 55-98 1.57e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.57e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 114431250    55 FTEMHCMSGHSNFVSCVCIIPSSDiyphgLIATGGNDHNICIFS 98
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGK-----YLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 104-138 2.15e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 2.15e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 114431250   104 PLYILKGHKDTVCSLS-SGKFGTLLSGSWDTTAKVW 138
Cdd:smart00320   4 LLKTLKGHTGPVTSVAfSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
55-98 7.25e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 7.25e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 114431250   55 FTEMHCMSGHSNFVSCVCIIPSSDiyphgLIATGGNDHNICIFS 98
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK-----LLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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