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Concise Results
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histone deacetylase complex subunit SAP130 isoform 1 [Mus musculus]
Protein Classification
List of domain hits
Name
Accession
Description
Interval
E-value
SAP130_C
pfam16014 Histone deacetylase complex subunit SAP130 C-terminus;
634-1039
0e+00
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain]
Cd Length: 371
Bit Score: 549.15
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 634 A Q GSSPRPSILRKKPAT D G mavrktllppqppdvatprvessmrsasgsprpag AKPK SEV HV SI A T PVTV SL E TISN QN 713
Cdd:pfam16014 1 A L GSSPRPSILRKKPAT E G ----------------------------------- AKPK PDI HV AV A P PVTV AV E ALPG QN 45
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 714 A EQ P T VAVP P TA Q Q P PPT IP SMI A A A S PPSQP AIA LST I P G A VP VTPP ---- ITTIA A T PT LS A p VGG T PSTVLGPPV PE 789
Cdd:pfam16014 46 S EQ Q T ASAS P PS Q H P AQA IP TIL A P A A PPSQP SVV LST L P A A MA VTPP ipas MANVV A P PT QP A - ASS T AACAVSSVL PE 124
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 790 IK V K E EAEP V D ITR pvs T VPPL ATNTV SP S L AL LA S NLS M P PS DL P PGASPRKKPRKQQHVISTEEG D MMETNSTD D EKS 869
Cdd:pfam16014 125 IK I K Q EAEP M D TSQ --- S VPPL TPTSI SP A L TS LA N NLS V P AG DL L PGASPRKKPRKQQHVISTEEG E MMETNSTD E EKS 201
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 870 A A K S L LVK AEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKK AM LQ EI ANQKGV S C 949
Cdd:pfam16014 202 A P K P L TSR AEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKK GT LQ DM ANQKGV T C 281
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 950 RAQGWK V HLCAAQLLQLTNLEHDVY E RLT N LQEG I IPKKKA A TDDDLHRINELIQGNMQRCKLVMDQI S EARDSM L KVLD 1029
Cdd:pfam16014 282 RAQGWK I HLCAAQLLQLTNLEHDVY S RLT T LQEG L IPKKKA G TDDDLHRINELIQGNMQRCKLVMDQI T EARDSM M KVLD 361
410
....*....|
gi 27881435 1030 HKDRVLKLLN 1039
Cdd:pfam16014 362 HKDRVLKLLN 371
PHA03247 super family
cl33720 large tegument protein UL36; Provisional
417-885
4.23e-07
large tegument protein UL36; Provisional
PHA03247 :Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 54.56
E-value: 4.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 417 PRIQPDY PPER SSLI P i SGH R A S PNPV A METRNDNRP S V P V Q fqyfl PTYPPS A Y P laah T YTPI TS SVSTIRQY P VSAQ 496
Cdd:PHA03247 2641 HPPPTVP PPER PRDD P - APG R V S RPRR A RRLGRAAQA S S P P Q ----- RPRRRA A R P ---- T VGSL TS LADPPPPP P TPEP 2710
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 497 AP NSTIT A qtgvgvastvhl N P MQLMTVD A SH A RHIQGIQ PAP ISTQGIQPA P I G tsgiq PA PIGT P GIHSAA P intqgl 576
Cdd:PHA03247 2711 AP HALVS A ------------ T P LPPGPAA A RQ A SPALPAA PAP PAVPAGPAT P G G ----- PA RPAR P PTTAGP P ------ 2767
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 577 Q PA AM A NQQPQ P EGKTSVVLADGATIVANPISN P FSA A PAATT V VQTHSQSASTNT PA QGSS P RP S ILRKK P AT dgmavr 656
Cdd:PHA03247 2768 A PA PP A APAAG P PRRLTRPAVASLSESRESLPS P WDP A DPPAA V LAPAAALPPAAS PA GPLP P PT S AQPTA P PP ------ 2841
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 657 ktll PP Q PP DVAT P R ---- VESSMRSASGSP R PAG AKP KSEVHVSIATPVTVSLET i S NQNAEQ P TVAVPPTA Q QPP P TI 732
Cdd:PHA03247 2842 ---- PP G PP PPSL P L ggsv APGGDVRRRPPS R SPA AKP AAPARPPVRRLARPAVSR - S TESFAL P PDQPERPP Q PQA P PP 2916
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 733 P SMIAAAS PP S QP AIALSTI P GAV P VTP P I T TI A ATP tls A P V G GT P STV LG P ------ P VP EIK V KEE A EPVDI tr P V S 806
Cdd:PHA03247 2917 P QPQPQPP PP P QP QPPPPPP P RPQ P PLA P T T DP A GAG --- E P S G AV P QPW LG A lvpgrv A VP RFR V PQP A PSREA -- P A S 2991
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 807 TV PPL a T NTVSPSLALL AS N L SMPPSDL PP GA S prkkp R KQ QHVIS -- TE EG D MMETNST D D E K S AAKS L LVKAEKRKS P 884
Cdd:PHA03247 2992 ST PPL - T GHSLSRVSSW AS S L ALHEETD PP PV S ----- L KQ TLWPP dd TE DS D ADSLFDS D S E R S DLEA L DPLPPEPHD P 3065
.
gi 27881435 885 P 885
Cdd:PHA03247 3066 F 3066
PHA03247 super family
cl33720 large tegument protein UL36; Provisional
98-492
1.17e-04
large tegument protein UL36; Provisional
PHA03247 :Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 46.47
E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 98 PP AH L T PA --------- VP LSFSEGLMKP P PKPTMPS RP I AP APPSTMSL P PKVP G QVTVTMES S - I P QASAI P VATISG 167
Cdd:PHA03247 2551 PP PP L P PA appaapdrs VP PPRPAPRPSE P AVTSRAR RP D AP PQSARPRA P VDDR G DPRGPAPP S p L P PDTHA P DPPPPS 2630
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 168 QQGHPSNLHHIMTTN V QMSIIRSNA P G P P ------------ LHIG AS HL P RGAAAA A VMSS - SKV T TVLR P TSQL P NAAT 234
Cdd:PHA03247 2631 PSPAANEPDPHPPPT V PPPERPRDD P A P G rvsrprrarrlg RAAQ AS SP P QRPRRR A ARPT v GSL T SLAD P PPPP P TPEP 2710
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 235 A QP A VQHLIHQ P IQSRPPVTT S STI P P A VVATVSATRAQS P V - ITTT A AHAADSTLSR P TLSIQHPPSAAISIQ RPA QSR 313
Cdd:PHA03247 2711 A PH A LVSATPL P PGPAAARQA S PAL P A A PAPPAVPAGPAT P G g PARP A RPPTTAGPPA P APPAAPAAGPPRRLT RPA VAS 2790
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 314 DVTT R IT LPS ------ H PA LGTPKQQLHTM A QKTIFSTGT P VA A ATV AP ILATNTL P STTTA G SVSHTQAP tsti V TMTM 387
Cdd:PHA03247 2791 LSES R ES LPS pwdpad P PA AVLAPAAALPP A ASPAGPLPP P TS A QPT AP PPPPGPP P PSLPL G GSVAPGGD ---- V RRRP 2866
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 388 PS H S SH A TAVTTSNI PV AKV vpqqithts P R IQPDYPP E RSS L I P ISGH R ASPNPVAMETRNDNR P SV P V Q F Q YFL P TY P 467
Cdd:PHA03247 2867 PS R S PA A KPAAPARP PV RRL --------- A R PAVSRST E SFA L P P DQPE R PPQPQAPPPPQPQPQ P PP P P Q P Q PPP P PP P 2937
410 420
....*....|....*....|....*
gi 27881435 468 PSAY PLA AH T YTPITSSV S TIRQY P 492
Cdd:PHA03247 2938 RPQP PLA PT T DPAGAGEP S GAVPQ P 2962
Name
Accession
Description
Interval
E-value
SAP130_C
pfam16014 Histone deacetylase complex subunit SAP130 C-terminus;
634-1039
0e+00
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain]
Cd Length: 371
Bit Score: 549.15
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 634 A Q GSSPRPSILRKKPAT D G mavrktllppqppdvatprvessmrsasgsprpag AKPK SEV HV SI A T PVTV SL E TISN QN 713
Cdd:pfam16014 1 A L GSSPRPSILRKKPAT E G ----------------------------------- AKPK PDI HV AV A P PVTV AV E ALPG QN 45
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 714 A EQ P T VAVP P TA Q Q P PPT IP SMI A A A S PPSQP AIA LST I P G A VP VTPP ---- ITTIA A T PT LS A p VGG T PSTVLGPPV PE 789
Cdd:pfam16014 46 S EQ Q T ASAS P PS Q H P AQA IP TIL A P A A PPSQP SVV LST L P A A MA VTPP ipas MANVV A P PT QP A - ASS T AACAVSSVL PE 124
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 790 IK V K E EAEP V D ITR pvs T VPPL ATNTV SP S L AL LA S NLS M P PS DL P PGASPRKKPRKQQHVISTEEG D MMETNSTD D EKS 869
Cdd:pfam16014 125 IK I K Q EAEP M D TSQ --- S VPPL TPTSI SP A L TS LA N NLS V P AG DL L PGASPRKKPRKQQHVISTEEG E MMETNSTD E EKS 201
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 870 A A K S L LVK AEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKK AM LQ EI ANQKGV S C 949
Cdd:pfam16014 202 A P K P L TSR AEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKK GT LQ DM ANQKGV T C 281
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 950 RAQGWK V HLCAAQLLQLTNLEHDVY E RLT N LQEG I IPKKKA A TDDDLHRINELIQGNMQRCKLVMDQI S EARDSM L KVLD 1029
Cdd:pfam16014 282 RAQGWK I HLCAAQLLQLTNLEHDVY S RLT T LQEG L IPKKKA G TDDDLHRINELIQGNMQRCKLVMDQI T EARDSM M KVLD 361
410
....*....|
gi 27881435 1030 HKDRVLKLLN 1039
Cdd:pfam16014 362 HKDRVLKLLN 371
PHA03247
PHA03247 large tegument protein UL36; Provisional
417-885
4.23e-07
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 54.56
E-value: 4.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 417 PRIQPDY PPER SSLI P i SGH R A S PNPV A METRNDNRP S V P V Q fqyfl PTYPPS A Y P laah T YTPI TS SVSTIRQY P VSAQ 496
Cdd:PHA03247 2641 HPPPTVP PPER PRDD P - APG R V S RPRR A RRLGRAAQA S S P P Q ----- RPRRRA A R P ---- T VGSL TS LADPPPPP P TPEP 2710
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 497 AP NSTIT A qtgvgvastvhl N P MQLMTVD A SH A RHIQGIQ PAP ISTQGIQPA P I G tsgiq PA PIGT P GIHSAA P intqgl 576
Cdd:PHA03247 2711 AP HALVS A ------------ T P LPPGPAA A RQ A SPALPAA PAP PAVPAGPAT P G G ----- PA RPAR P PTTAGP P ------ 2767
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 577 Q PA AM A NQQPQ P EGKTSVVLADGATIVANPISN P FSA A PAATT V VQTHSQSASTNT PA QGSS P RP S ILRKK P AT dgmavr 656
Cdd:PHA03247 2768 A PA PP A APAAG P PRRLTRPAVASLSESRESLPS P WDP A DPPAA V LAPAAALPPAAS PA GPLP P PT S AQPTA P PP ------ 2841
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 657 ktll PP Q PP DVAT P R ---- VESSMRSASGSP R PAG AKP KSEVHVSIATPVTVSLET i S NQNAEQ P TVAVPPTA Q QPP P TI 732
Cdd:PHA03247 2842 ---- PP G PP PPSL P L ggsv APGGDVRRRPPS R SPA AKP AAPARPPVRRLARPAVSR - S TESFAL P PDQPERPP Q PQA P PP 2916
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 733 P SMIAAAS PP S QP AIALSTI P GAV P VTP P I T TI A ATP tls A P V G GT P STV LG P ------ P VP EIK V KEE A EPVDI tr P V S 806
Cdd:PHA03247 2917 P QPQPQPP PP P QP QPPPPPP P RPQ P PLA P T T DP A GAG --- E P S G AV P QPW LG A lvpgrv A VP RFR V PQP A PSREA -- P A S 2991
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 807 TV PPL a T NTVSPSLALL AS N L SMPPSDL PP GA S prkkp R KQ QHVIS -- TE EG D MMETNST D D E K S AAKS L LVKAEKRKS P 884
Cdd:PHA03247 2992 ST PPL - T GHSLSRVSSW AS S L ALHEETD PP PV S ----- L KQ TLWPP dd TE DS D ADSLFDS D S E R S DLEA L DPLPPEPHD P 3065
.
gi 27881435 885 P 885
Cdd:PHA03247 3066 F 3066
PHA03247
PHA03247 large tegument protein UL36; Provisional
537-848
6.18e-06
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 50.71
E-value: 6.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 537 P APISTQGIQ P APIGTSGIQ PA PIGTPGIHS A A P INTQGLQ P AAMANQQPQ P EGKTSVVLADG A tivan P ISN P F S AA PA 616
Cdd:PHA03247 2560 P PAAPDRSVP P PRPAPRPSE PA VTSRARRPD A P P QSARPRA P VDDRGDPRG P APPSPLPPDTH A ----- P DPP P P S PS PA 2634
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 617 A TTVVQTHSQSA - STNT P AQGSS P RPSILRKKPATD G M A VRKTLL P PQ P PDV A TPRVES S M r SASGS P R P AGAK P KSEV H 695
Cdd:PHA03247 2635 A NEPDPHPPPTV p PPER P RDDPA P GRVSRPRRARRL G R A AQASSP P QR P RRR A ARPTVG S L - TSLAD P P P PPPT P EPAP H 2713
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 696 VSIATPVTVSLETISN Q NAEQPTV A VP P T A QQPP P TI P SMI A AASP P SQP A IALSTI P G A V P VT -- P PIT T IA A TPT LS A 773
Cdd:PHA03247 2714 ALVSATPLPPGPAAAR Q ASPALPA A PA P P A VPAG P AT P GGP A RPAR P PTT A GPPAPA P P A A P AA gp P RRL T RP A VAS LS E 2793
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27881435 774 PVGGT PS TVLGPPV P EIKVKEE A EPVDITR P VSTV PP LATNT - VS P SLALLASNL S M P P - SDLP PG ASP R KK P RKQQ 848
Cdd:PHA03247 2794 SRESL PS PWDPADP P AAVLAPA A ALPPAAS P AGPL PP PTSAQ p TA P PPPPGPPPP S L P L g GSVA PG GDV R RR P PSRS 2870
PHA03247
PHA03247 large tegument protein UL36; Provisional
98-492
1.17e-04
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 46.47
E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 98 PP AH L T PA --------- VP LSFSEGLMKP P PKPTMPS RP I AP APPSTMSL P PKVP G QVTVTMES S - I P QASAI P VATISG 167
Cdd:PHA03247 2551 PP PP L P PA appaapdrs VP PPRPAPRPSE P AVTSRAR RP D AP PQSARPRA P VDDR G DPRGPAPP S p L P PDTHA P DPPPPS 2630
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 168 QQGHPSNLHHIMTTN V QMSIIRSNA P G P P ------------ LHIG AS HL P RGAAAA A VMSS - SKV T TVLR P TSQL P NAAT 234
Cdd:PHA03247 2631 PSPAANEPDPHPPPT V PPPERPRDD P A P G rvsrprrarrlg RAAQ AS SP P QRPRRR A ARPT v GSL T SLAD P PPPP P TPEP 2710
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 235 A QP A VQHLIHQ P IQSRPPVTT S STI P P A VVATVSATRAQS P V - ITTT A AHAADSTLSR P TLSIQHPPSAAISIQ RPA QSR 313
Cdd:PHA03247 2711 A PH A LVSATPL P PGPAAARQA S PAL P A A PAPPAVPAGPAT P G g PARP A RPPTTAGPPA P APPAAPAAGPPRRLT RPA VAS 2790
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 314 DVTT R IT LPS ------ H PA LGTPKQQLHTM A QKTIFSTGT P VA A ATV AP ILATNTL P STTTA G SVSHTQAP tsti V TMTM 387
Cdd:PHA03247 2791 LSES R ES LPS pwdpad P PA AVLAPAAALPP A ASPAGPLPP P TS A QPT AP PPPPGPP P PSLPL G GSVAPGGD ---- V RRRP 2866
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 388 PS H S SH A TAVTTSNI PV AKV vpqqithts P R IQPDYPP E RSS L I P ISGH R ASPNPVAMETRNDNR P SV P V Q F Q YFL P TY P 467
Cdd:PHA03247 2867 PS R S PA A KPAAPARP PV RRL --------- A R PAVSRST E SFA L P P DQPE R PPQPQAPPPPQPQPQ P PP P P Q P Q PPP P PP P 2937
410 420
....*....|....*....|....*
gi 27881435 468 PSAY PLA AH T YTPITSSV S TIRQY P 492
Cdd:PHA03247 2938 RPQP PLA PT T DPAGAGEP S GAVPQ P 2962
Atrophin-1
pfam03154 Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
453-828
3.27e-04
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain]
Cd Length: 991
Bit Score: 44.76
E-value: 3.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 453 P SVPV Q FQYFL P TY PP SAYPLA A H T YT P IT S SV S TIR Q - Y P VSA Q A PN S T I - TA QTGVGVAS T VH L N P MQ L MT vdashar 530
Cdd:pfam03154 172 P VLQA Q SGAAS P PS PP PPGTTQ A A T AG P TP S AP S VPP Q g S P ATS Q P PN Q T Q s TA APHTLIQQ T PT L H P QR L PS ------- 244
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 531 hiqgiq P A P ISTQGI QP A P IGTSGI QP A P ig T P GI H SAA P INTQG LQ PAAMAN Q Q P Q P E gktsvvladg ATIVAN P I S NP 610
Cdd:pfam03154 245 ------ P H P PLQPMT QP P P PSQVSP QP L P -- Q P SL H GQM P PMPHS LQ TGPSHM Q H P V P P ---------- QPFPLT P Q S SQ 306
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 611 FSAA P AATTVVQTH SQ SASTNT P A Q GSSPRPSIL R KK P ATDG - MAVRKTLL PP QP P DVAT P RVE S SMRSASG S ------- 682
Cdd:pfam03154 307 SQVP P GPSPAAPGQ SQ QRIHTP P S Q SQLQSQQPP R EQ P LPPA p LSMPHIKP PP TT P IPQL P NPQ S HKHPPHL S gpspfqm 386
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 683 ---- P R P AGA KP K S EV --- H VSI A T P VTVS L ETI S N Q ---- N A EQ P TVAVPPTAQQ P PPTI P SMIAAASP PSQ PAIAL - S 750
Cdd:pfam03154 387 nsnl P P P PAL KP L S SL sth H PPS A H P PPLQ L MPQ S Q Q lppp P A QP P VLTQSQSLPP P AASH P PTSGLHQV PSQ SPFPQ h P 466
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 751 TI PG AV P V ----- T PP IT T IA A T P TLSA P VGGTP S T ------ VLGP P V P EIKV KEEA e PVDITR P V S TV PP LATNTVS P S 819
Cdd:pfam03154 467 FV PG GP P P itpps G PP TS T SS A M P GIQP P SSASV S S sgpvpa AVSC P L P PVQI KEEA - LDEAEE P E S PP PP PRSPSPE P T 545
....*....
gi 27881435 820 LALLA S NL S 828
Cdd:pfam03154 546 VVNTP S HA S 554
Name
Accession
Description
Interval
E-value
SAP130_C
pfam16014 Histone deacetylase complex subunit SAP130 C-terminus;
634-1039
0e+00
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain]
Cd Length: 371
Bit Score: 549.15
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 634 A Q GSSPRPSILRKKPAT D G mavrktllppqppdvatprvessmrsasgsprpag AKPK SEV HV SI A T PVTV SL E TISN QN 713
Cdd:pfam16014 1 A L GSSPRPSILRKKPAT E G ----------------------------------- AKPK PDI HV AV A P PVTV AV E ALPG QN 45
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 714 A EQ P T VAVP P TA Q Q P PPT IP SMI A A A S PPSQP AIA LST I P G A VP VTPP ---- ITTIA A T PT LS A p VGG T PSTVLGPPV PE 789
Cdd:pfam16014 46 S EQ Q T ASAS P PS Q H P AQA IP TIL A P A A PPSQP SVV LST L P A A MA VTPP ipas MANVV A P PT QP A - ASS T AACAVSSVL PE 124
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 790 IK V K E EAEP V D ITR pvs T VPPL ATNTV SP S L AL LA S NLS M P PS DL P PGASPRKKPRKQQHVISTEEG D MMETNSTD D EKS 869
Cdd:pfam16014 125 IK I K Q EAEP M D TSQ --- S VPPL TPTSI SP A L TS LA N NLS V P AG DL L PGASPRKKPRKQQHVISTEEG E MMETNSTD E EKS 201
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 870 A A K S L LVK AEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKK AM LQ EI ANQKGV S C 949
Cdd:pfam16014 202 A P K P L TSR AEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKK GT LQ DM ANQKGV T C 281
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 950 RAQGWK V HLCAAQLLQLTNLEHDVY E RLT N LQEG I IPKKKA A TDDDLHRINELIQGNMQRCKLVMDQI S EARDSM L KVLD 1029
Cdd:pfam16014 282 RAQGWK I HLCAAQLLQLTNLEHDVY S RLT T LQEG L IPKKKA G TDDDLHRINELIQGNMQRCKLVMDQI T EARDSM M KVLD 361
410
....*....|
gi 27881435 1030 HKDRVLKLLN 1039
Cdd:pfam16014 362 HKDRVLKLLN 371
PHA03247
PHA03247 large tegument protein UL36; Provisional
417-885
4.23e-07
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 54.56
E-value: 4.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 417 PRIQPDY PPER SSLI P i SGH R A S PNPV A METRNDNRP S V P V Q fqyfl PTYPPS A Y P laah T YTPI TS SVSTIRQY P VSAQ 496
Cdd:PHA03247 2641 HPPPTVP PPER PRDD P - APG R V S RPRR A RRLGRAAQA S S P P Q ----- RPRRRA A R P ---- T VGSL TS LADPPPPP P TPEP 2710
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 497 AP NSTIT A qtgvgvastvhl N P MQLMTVD A SH A RHIQGIQ PAP ISTQGIQPA P I G tsgiq PA PIGT P GIHSAA P intqgl 576
Cdd:PHA03247 2711 AP HALVS A ------------ T P LPPGPAA A RQ A SPALPAA PAP PAVPAGPAT P G G ----- PA RPAR P PTTAGP P ------ 2767
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 577 Q PA AM A NQQPQ P EGKTSVVLADGATIVANPISN P FSA A PAATT V VQTHSQSASTNT PA QGSS P RP S ILRKK P AT dgmavr 656
Cdd:PHA03247 2768 A PA PP A APAAG P PRRLTRPAVASLSESRESLPS P WDP A DPPAA V LAPAAALPPAAS PA GPLP P PT S AQPTA P PP ------ 2841
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 657 ktll PP Q PP DVAT P R ---- VESSMRSASGSP R PAG AKP KSEVHVSIATPVTVSLET i S NQNAEQ P TVAVPPTA Q QPP P TI 732
Cdd:PHA03247 2842 ---- PP G PP PPSL P L ggsv APGGDVRRRPPS R SPA AKP AAPARPPVRRLARPAVSR - S TESFAL P PDQPERPP Q PQA P PP 2916
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 733 P SMIAAAS PP S QP AIALSTI P GAV P VTP P I T TI A ATP tls A P V G GT P STV LG P ------ P VP EIK V KEE A EPVDI tr P V S 806
Cdd:PHA03247 2917 P QPQPQPP PP P QP QPPPPPP P RPQ P PLA P T T DP A GAG --- E P S G AV P QPW LG A lvpgrv A VP RFR V PQP A PSREA -- P A S 2991
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 807 TV PPL a T NTVSPSLALL AS N L SMPPSDL PP GA S prkkp R KQ QHVIS -- TE EG D MMETNST D D E K S AAKS L LVKAEKRKS P 884
Cdd:PHA03247 2992 ST PPL - T GHSLSRVSSW AS S L ALHEETD PP PV S ----- L KQ TLWPP dd TE DS D ADSLFDS D S E R S DLEA L DPLPPEPHD P 3065
.
gi 27881435 885 P 885
Cdd:PHA03247 3066 F 3066
PHA03247
PHA03247 large tegument protein UL36; Provisional
537-848
6.18e-06
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 50.71
E-value: 6.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 537 P APISTQGIQ P APIGTSGIQ PA PIGTPGIHS A A P INTQGLQ P AAMANQQPQ P EGKTSVVLADG A tivan P ISN P F S AA PA 616
Cdd:PHA03247 2560 P PAAPDRSVP P PRPAPRPSE PA VTSRARRPD A P P QSARPRA P VDDRGDPRG P APPSPLPPDTH A ----- P DPP P P S PS PA 2634
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 617 A TTVVQTHSQSA - STNT P AQGSS P RPSILRKKPATD G M A VRKTLL P PQ P PDV A TPRVES S M r SASGS P R P AGAK P KSEV H 695
Cdd:PHA03247 2635 A NEPDPHPPPTV p PPER P RDDPA P GRVSRPRRARRL G R A AQASSP P QR P RRR A ARPTVG S L - TSLAD P P P PPPT P EPAP H 2713
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 696 VSIATPVTVSLETISN Q NAEQPTV A VP P T A QQPP P TI P SMI A AASP P SQP A IALSTI P G A V P VT -- P PIT T IA A TPT LS A 773
Cdd:PHA03247 2714 ALVSATPLPPGPAAAR Q ASPALPA A PA P P A VPAG P AT P GGP A RPAR P PTT A GPPAPA P P A A P AA gp P RRL T RP A VAS LS E 2793
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27881435 774 PVGGT PS TVLGPPV P EIKVKEE A EPVDITR P VSTV PP LATNT - VS P SLALLASNL S M P P - SDLP PG ASP R KK P RKQQ 848
Cdd:PHA03247 2794 SRESL PS PWDPADP P AAVLAPA A ALPPAAS P AGPL PP PTSAQ p TA P PPPPGPPPP S L P L g GSVA PG GDV R RR P PSRS 2870
PHA03247
PHA03247 large tegument protein UL36; Provisional
98-492
1.17e-04
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 46.47
E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 98 PP AH L T PA --------- VP LSFSEGLMKP P PKPTMPS RP I AP APPSTMSL P PKVP G QVTVTMES S - I P QASAI P VATISG 167
Cdd:PHA03247 2551 PP PP L P PA appaapdrs VP PPRPAPRPSE P AVTSRAR RP D AP PQSARPRA P VDDR G DPRGPAPP S p L P PDTHA P DPPPPS 2630
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 168 QQGHPSNLHHIMTTN V QMSIIRSNA P G P P ------------ LHIG AS HL P RGAAAA A VMSS - SKV T TVLR P TSQL P NAAT 234
Cdd:PHA03247 2631 PSPAANEPDPHPPPT V PPPERPRDD P A P G rvsrprrarrlg RAAQ AS SP P QRPRRR A ARPT v GSL T SLAD P PPPP P TPEP 2710
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 235 A QP A VQHLIHQ P IQSRPPVTT S STI P P A VVATVSATRAQS P V - ITTT A AHAADSTLSR P TLSIQHPPSAAISIQ RPA QSR 313
Cdd:PHA03247 2711 A PH A LVSATPL P PGPAAARQA S PAL P A A PAPPAVPAGPAT P G g PARP A RPPTTAGPPA P APPAAPAAGPPRRLT RPA VAS 2790
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 314 DVTT R IT LPS ------ H PA LGTPKQQLHTM A QKTIFSTGT P VA A ATV AP ILATNTL P STTTA G SVSHTQAP tsti V TMTM 387
Cdd:PHA03247 2791 LSES R ES LPS pwdpad P PA AVLAPAAALPP A ASPAGPLPP P TS A QPT AP PPPPGPP P PSLPL G GSVAPGGD ---- V RRRP 2866
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 388 PS H S SH A TAVTTSNI PV AKV vpqqithts P R IQPDYPP E RSS L I P ISGH R ASPNPVAMETRNDNR P SV P V Q F Q YFL P TY P 467
Cdd:PHA03247 2867 PS R S PA A KPAAPARP PV RRL --------- A R PAVSRST E SFA L P P DQPE R PPQPQAPPPPQPQPQ P PP P P Q P Q PPP P PP P 2937
410 420
....*....|....*....|....*
gi 27881435 468 PSAY PLA AH T YTPITSSV S TIRQY P 492
Cdd:PHA03247 2938 RPQP PLA PT T DPAGAGEP S GAVPQ P 2962
Atrophin-1
pfam03154 Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
453-828
3.27e-04
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain]
Cd Length: 991
Bit Score: 44.76
E-value: 3.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 453 P SVPV Q FQYFL P TY PP SAYPLA A H T YT P IT S SV S TIR Q - Y P VSA Q A PN S T I - TA QTGVGVAS T VH L N P MQ L MT vdashar 530
Cdd:pfam03154 172 P VLQA Q SGAAS P PS PP PPGTTQ A A T AG P TP S AP S VPP Q g S P ATS Q P PN Q T Q s TA APHTLIQQ T PT L H P QR L PS ------- 244
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 531 hiqgiq P A P ISTQGI QP A P IGTSGI QP A P ig T P GI H SAA P INTQG LQ PAAMAN Q Q P Q P E gktsvvladg ATIVAN P I S NP 610
Cdd:pfam03154 245 ------ P H P PLQPMT QP P P PSQVSP QP L P -- Q P SL H GQM P PMPHS LQ TGPSHM Q H P V P P ---------- QPFPLT P Q S SQ 306
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 611 FSAA P AATTVVQTH SQ SASTNT P A Q GSSPRPSIL R KK P ATDG - MAVRKTLL PP QP P DVAT P RVE S SMRSASG S ------- 682
Cdd:pfam03154 307 SQVP P GPSPAAPGQ SQ QRIHTP P S Q SQLQSQQPP R EQ P LPPA p LSMPHIKP PP TT P IPQL P NPQ S HKHPPHL S gpspfqm 386
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 683 ---- P R P AGA KP K S EV --- H VSI A T P VTVS L ETI S N Q ---- N A EQ P TVAVPPTAQQ P PPTI P SMIAAASP PSQ PAIAL - S 750
Cdd:pfam03154 387 nsnl P P P PAL KP L S SL sth H PPS A H P PPLQ L MPQ S Q Q lppp P A QP P VLTQSQSLPP P AASH P PTSGLHQV PSQ SPFPQ h P 466
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 751 TI PG AV P V ----- T PP IT T IA A T P TLSA P VGGTP S T ------ VLGP P V P EIKV KEEA e PVDITR P V S TV PP LATNTVS P S 819
Cdd:pfam03154 467 FV PG GP P P itpps G PP TS T SS A M P GIQP P SSASV S S sgpvpa AVSC P L P PVQI KEEA - LDEAEE P E S PP PP PRSPSPE P T 545
....*....
gi 27881435 820 LALLA S NL S 828
Cdd:pfam03154 546 VVNTP S HA S 554
PRK14950
PRK14950 DNA polymerase III subunits gamma and tau; Provisional
740-860
4.13e-03
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237864 [Multi-domain]
Cd Length: 585
Bit Score: 40.95
E-value: 4.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 740 SPPS Q PAIA L ST I PGAVPVT P PITTIAA T PTLSA PV GG TP STVLG P PVPEIKVKEEA EPV -- DI T R P VSTVP P L A TNTVS 817
Cdd:PRK14950 344 TSYG Q LPLE L AV I EALLVPV P APQPAKP T AAAPS PV RP TP APSTR P KAAAAANIPPK EPV re TA T P P PVPPR P V A PPVPH 423
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 27881435 818 PSLALLASNLSMP P S D LP P GAS P r KK P R K QQHVISTEE GD MM E 860
Cdd:PRK14950 424 TPESAPKLTRAAI P V D EK P KYT P - PA P P K EEEKALIAD GD VL E 465
PHA02732
PHA02732 hypothetical protein; Provisional
237-466
7.21e-03
hypothetical protein; Provisional
Pssm-ID: 165099 [Multi-domain]
Cd Length: 1467
Bit Score: 40.51
E-value: 7.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 237 PA V Q H L IHQPIQSRPPVTTSST -- IPP AVVA ---- TVSATR A QSPVITTTAAHA A DS T LSR P TL S IQHPPSAA IS IQ r P A 310
Cdd:PHA02732 1182 PA P Q L L SSYIPTGSVLYQDPIF ty IPP GIIG msgt NTFTFK A AQLQLSAASSPP A AT T PTP P PS S SSSSSAQS IS TS - P G 1260
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 311 Q SR ----- DV T TR I TLPSH PAL G TPK qqlhtmaqktifs T G TPV A AAT V apilatntlp STTT A GSVSHTQAPT S TIVTM 385
Cdd:PHA02732 1261 Q IQ ivlng ST T IH I NFLFF PAL S TPK ------------- I G QIL A MPI V ---------- NSSG A FISLYVNSAI S ANFNV 1317
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881435 386 T MPSHS S HA T AVTTSNIPVAKVV P QQITHTSPRIQPDYPP E r S SLIP IS GHRASPNPV A MET RN DNRP S V P VQ F QY F L P T 465
Cdd:PHA02732 1318 T IEYVF S NG T VIKRFTDEPGQIF P LPLINGDEEVIISVEN E - S TTFN IS ANNLGSAQL A LQL RN AISA S L P GP F AF F G P I 1396
.
gi 27881435 466 Y 466
Cdd:PHA02732 1397 L 1397
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
