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Conserved domains on  [gi|27477061|ref|NP_775259|]
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protein unc-45 homolog B isoform 1 [Homo sapiens]

Protein Classification

UNC45-central domain-containing protein( domain architecture ID 13518781)

UNC45-central domain-containing protein similar to Homo sapiens SWI5-dependent HO expression protein 4 (SHE4) required for mother cell-specific ho expression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UNC45-central pfam11701
Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C. ...
 344-489 9.74e-35

Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C.elegans is expressed in two forms from different genomic positions in mammals, as a general tissue protein UNC-45a and a specific form Unc-45b expressed only in striated and skeletal muscle. All members carry up to three amino-terminal tetratricopeptide repeat (TPR) domains towards their N-terminal, a UCS domain at the C-terminal that contains a number of Arm repeats pfam00514 and this central region of approximately 400 residues. Both the general form and the muscle form of UNC-45 function in myotube formation through cell fusion. Myofibril formation requires both GC and SM UNC-45, consistent with the fact that the cytoskeleton is necessary for the development and maintenance of organized myofibrils. The S. pombe Rng3p, is crucial for cell shape, normal actin cytoskeleton, and contractile ring assembly, and is essential for assembly of the myosin II-containing progenitors of the contractile ring. Widespread defects in the cytoskeleton are found in null mutants of all three fungal proteins. Mammalian Unc45 is found to act as a specific chaperone during the folding of myosin and the assembly of striated muscle by forming a stable complex with the general chaperone Hsp90. The exact function of this central region is not known.


:

Pssm-ID: 432011  Cd Length: 151  Bit Score: 129.58  E-value: 9.74e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061   344 CLPLTDNTRMLASILINKLyddlrCDPERDHFRKICEEYITGKFDPQDMDKNLNAIQTVSGILQGPFDLGNQLLGLKGVM 423
Cdd:pfam11701  11 DLRLPESVRSLALLILSKL-----LEAAKEEFEEKFSEFITSLLADGTNDDLIIAFSALAALFPVPPDVASALFLSEGFL 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27477061   424 EMMVALCGS-ERETDQLVAVEALIHASTKLSRATFIITNGVSLLKQIYKTTKNEkIKIRTLVGLCKL 489
Cdd:pfam11701  86 ESLLPLVESkKSRKVELAALELLSAACIDKACREAISKNYVDWLEELLKSSDDE-IKALAAVVLAKL 151
3a0801s09 super family cl36792
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 6-154 6.02e-12

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


The actual alignment was detected with superfamily member TIGR00990:

Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 69.63  E-value: 6.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061     6 AVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDkallATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQ 85
Cdd:TIGR00990 127 AAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPD----PVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNRRAN 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061    86 ALEHLGKLDQAFKDVQ-RCATLEPRNQNFQEMLRR-LNTSIQEKLRVQFSTD-------SRVQKMFEIL--------LDE 148
Cdd:TIGR00990 203 AYDGLGKYADALLDLTaSCIIDGFRNEQSAQAVERlLKKFAESKAKEILETKpenlpsvTFVGNYLQSFrpkprpagLED 282


                  ....*.
gi 27477061   149 NSEADK 154
Cdd:TIGR00990 283 SNELDE 288
 
Name Accession Description Interval E-value
UNC45-central pfam11701
Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C. ...
 344-489 9.74e-35

Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C.elegans is expressed in two forms from different genomic positions in mammals, as a general tissue protein UNC-45a and a specific form Unc-45b expressed only in striated and skeletal muscle. All members carry up to three amino-terminal tetratricopeptide repeat (TPR) domains towards their N-terminal, a UCS domain at the C-terminal that contains a number of Arm repeats pfam00514 and this central region of approximately 400 residues. Both the general form and the muscle form of UNC-45 function in myotube formation through cell fusion. Myofibril formation requires both GC and SM UNC-45, consistent with the fact that the cytoskeleton is necessary for the development and maintenance of organized myofibrils. The S. pombe Rng3p, is crucial for cell shape, normal actin cytoskeleton, and contractile ring assembly, and is essential for assembly of the myosin II-containing progenitors of the contractile ring. Widespread defects in the cytoskeleton are found in null mutants of all three fungal proteins. Mammalian Unc45 is found to act as a specific chaperone during the folding of myosin and the assembly of striated muscle by forming a stable complex with the general chaperone Hsp90. The exact function of this central region is not known.


Pssm-ID: 432011  Cd Length: 151  Bit Score: 129.58  E-value: 9.74e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061   344 CLPLTDNTRMLASILINKLyddlrCDPERDHFRKICEEYITGKFDPQDMDKNLNAIQTVSGILQGPFDLGNQLLGLKGVM 423
Cdd:pfam11701  11 DLRLPESVRSLALLILSKL-----LEAAKEEFEEKFSEFITSLLADGTNDDLIIAFSALAALFPVPPDVASALFLSEGFL 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27477061   424 EMMVALCGS-ERETDQLVAVEALIHASTKLSRATFIITNGVSLLKQIYKTTKNEkIKIRTLVGLCKL 489
Cdd:pfam11701  86 ESLLPLVESkKSRKVELAALELLSAACIDKACREAISKNYVDWLEELLKSSDDE-IKALAAVVLAKL 151
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 6-154 6.02e-12

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 69.63  E-value: 6.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061     6 AVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDkallATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQ 85
Cdd:TIGR00990 127 AAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPD----PVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNRRAN 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061    86 ALEHLGKLDQAFKDVQ-RCATLEPRNQNFQEMLRR-LNTSIQEKLRVQFSTD-------SRVQKMFEIL--------LDE 148
Cdd:TIGR00990 203 AYDGLGKYADALLDLTaSCIIDGFRNEQSAQAVERlLKKFAESKAKEILETKpenlpsvTFVGNYLQSFrpkprpagLED 282


                  ....*.
gi 27477061   149 NSEADK 154
Cdd:TIGR00990 283 SNELDE 288
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
5-108 1.98e-11

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 64.55  E-value: 1.98e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061   5 EAVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDkalLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRC 84
Cdd:COG4785  72 LAQLYYERGVAYDSLGDYDLAIADFDQALELDPD---LAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRG 148

                        90       100
                ....*....|....*....|....
gi 27477061  85 QALEHLGKLDQAFKDVQRCATLEP 108
Cdd:COG4785 149 IALYYLGRYELAIADLEKALELDP 172
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 6-126 2.39e-08

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 57.10  E-value: 2.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061    6 AVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDKAllaTLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQ 85
Cdd:PLN03088   2 AKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNA---ELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGT 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 27477061   86 ALEHLGKLDQAFKDVQRCATLEPRNQNFQEMLRRLNTSIQE 126
Cdd:PLN03088  79 ACMKLEEYQTAKAALEKGASLAPGDSRFTKLIKECDEKIAE 119
 
Name Accession Description Interval E-value
UNC45-central pfam11701
Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C. ...
 344-489 9.74e-35

Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C.elegans is expressed in two forms from different genomic positions in mammals, as a general tissue protein UNC-45a and a specific form Unc-45b expressed only in striated and skeletal muscle. All members carry up to three amino-terminal tetratricopeptide repeat (TPR) domains towards their N-terminal, a UCS domain at the C-terminal that contains a number of Arm repeats pfam00514 and this central region of approximately 400 residues. Both the general form and the muscle form of UNC-45 function in myotube formation through cell fusion. Myofibril formation requires both GC and SM UNC-45, consistent with the fact that the cytoskeleton is necessary for the development and maintenance of organized myofibrils. The S. pombe Rng3p, is crucial for cell shape, normal actin cytoskeleton, and contractile ring assembly, and is essential for assembly of the myosin II-containing progenitors of the contractile ring. Widespread defects in the cytoskeleton are found in null mutants of all three fungal proteins. Mammalian Unc45 is found to act as a specific chaperone during the folding of myosin and the assembly of striated muscle by forming a stable complex with the general chaperone Hsp90. The exact function of this central region is not known.


Pssm-ID: 432011  Cd Length: 151  Bit Score: 129.58  E-value: 9.74e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061   344 CLPLTDNTRMLASILINKLyddlrCDPERDHFRKICEEYITGKFDPQDMDKNLNAIQTVSGILQGPFDLGNQLLGLKGVM 423
Cdd:pfam11701  11 DLRLPESVRSLALLILSKL-----LEAAKEEFEEKFSEFITSLLADGTNDDLIIAFSALAALFPVPPDVASALFLSEGFL 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27477061   424 EMMVALCGS-ERETDQLVAVEALIHASTKLSRATFIITNGVSLLKQIYKTTKNEkIKIRTLVGLCKL 489
Cdd:pfam11701  86 ESLLPLVESkKSRKVELAALELLSAACIDKACREAISKNYVDWLEELLKSSDDE-IKALAAVVLAKL 151
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 6-154 6.02e-12

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 69.63  E-value: 6.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061     6 AVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDkallATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQ 85
Cdd:TIGR00990 127 AAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPD----PVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNRRAN 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061    86 ALEHLGKLDQAFKDVQ-RCATLEPRNQNFQEMLRR-LNTSIQEKLRVQFSTD-------SRVQKMFEIL--------LDE 148
Cdd:TIGR00990 203 AYDGLGKYADALLDLTaSCIIDGFRNEQSAQAVERlLKKFAESKAKEILETKpenlpsvTFVGNYLQSFrpkprpagLED 282


                  ....*.
gi 27477061   149 NSEADK 154
Cdd:TIGR00990 283 SNELDE 288
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
5-108 1.98e-11

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 64.55  E-value: 1.98e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061   5 EAVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDkalLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRC 84
Cdd:COG4785  72 LAQLYYERGVAYDSLGDYDLAIADFDQALELDPD---LAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRG 148

                        90       100
                ....*....|....*....|....
gi 27477061  85 QALEHLGKLDQAFKDVQRCATLEP 108
Cdd:COG4785 149 IALYYLGRYELAIADLEKALELDP 172
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
13-120 1.65e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.55  E-value: 1.65e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061  13 GNRHFQLQDYKAATNSYSQALKLTKDkalLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGK 92
Cdd:COG0457  49 GLAYLRLGRYEEALADYEQALELDPD---DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGR 125

                        90       100
                ....*....|....*....|....*...
gi 27477061  93 LDQAFKDVQRCATLEPRNQNFQEMLRRL 120
Cdd:COG0457 126 YDEAIEAYERALELDPDDADALYNLGIA 153
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
13-110 1.89e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.17  E-value: 1.89e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061  13 GNRHFQLQDYKAATNSYSQALKLTKDkalLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGK 92
Cdd:COG0457  15 GLAYRRLGRYEEAIEDYEKALELDPD---DAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGR 91

                        90
                ....*....|....*...
gi 27477061  93 LDQAFKDVQRCATLEPRN 110
Cdd:COG0457  92 YEEALEDYDKALELDPDD 109
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 6-126 2.39e-08

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 57.10  E-value: 2.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061    6 AVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDKAllaTLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQ 85
Cdd:PLN03088   2 AKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNA---ELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGT 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 27477061   86 ALEHLGKLDQAFKDVQRCATLEPRNQNFQEMLRRLNTSIQE 126
Cdd:PLN03088  79 ACMKLEEYQTAKAALEKGASLAPGDSRFTKLIKECDEKIAE 119
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 13-121 2.40e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 53.47  E-value: 2.40e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061  13 GNRHFQLQDYKAATNSYSQALKLTKDKAllaTLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGK 92
Cdd:COG4235  24 GRAYLRLGRYDEALAAYEKALRLDPDNA---DALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGD 100

                        90       100
                ....*....|....*....|....*....
gi 27477061  93 LDQAFKDVQRCATLEPRNQNFQEMLRRLN 121
Cdd:COG4235 101 YAEAIAAWQKLLALLPADAPARLLEASIA 129
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 5-110 3.56e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 57.31  E-value: 3.56e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061   5 EAVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDkalLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRC 84
Cdd:COG3914  77 LAALLELAALLLQALGRYEEALALYRRALALNPD---NAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLG 153

                        90       100
                ....*....|....*....|....*.
gi 27477061  85 QALEHLGKLDQAFKDVQRCATLEPRN 110
Cdd:COG3914 154 EALRRLGRLEEAIAALRRALELDPDN 179
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 13-110 1.78e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 55.00  E-value: 1.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061  13 GNRHFQLQDYKAATNSYSQALKLTKDkalLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGK 92
Cdd:COG3914 119 GNLLLALGRLEEALAALRRALALNPD---FAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGR 195

                        90
                ....*....|....*...
gi 27477061  93 LDQAFKDVQRCATLEPRN 110
Cdd:COG3914 196 LEEAIAAYRRALELDPDN 213
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
13-177 1.91e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.09  E-value: 1.91e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061  13 GNRHFQLQDYKAATNSYSQALKLTKDkalLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGK 92
Cdd:COG0457  83 GLALQALGRYEEALEDYDKALELDPD---DAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGR 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061  93 LDQAFKDVQRCATLEPRNQNFQEMLRRLNTSIQEKLRVQFSTDSRVQKMFEILLDENSEADKREKAANNLIVLGREEAGA 172
Cdd:COG0457 160 YEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALA 239


                ....*
gi 27477061 173 EKIFQ 177
Cdd:COG0457 240 LYQYR 244
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 6-120 1.42e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 48.65  E-value: 1.42e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061   6 AVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDKAllaTLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQ 85
Cdd:COG4783   4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNP---EAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGL 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 27477061  86 ALEHLGKLDQAFKDVQRCATLEPRNQNFQEMLRRL 120
Cdd:COG4783  81 ALLKAGDYDEALALLEKALKLDPEHPEAYLRLARA 115
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
16-109 2.84e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 46.32  E-value: 2.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061  16 HFQLQDYKAATNSYSQALKLTKDkalLATLYRNRAACGLKTESYVQAAsDASRAIDINSSDIKALYRRCQALEHLGKLDQ 95
Cdd:COG3063   2 YLKLGDLEEAEEYYEKALELDPD---NADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDE 77

                        90
                ....*....|....
gi 27477061  96 AFKDVQRCATLEPR 109
Cdd:COG3063  78 ALAYLERALELDPS 91
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 16-108 1.07e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.49  E-value: 1.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061  16 HFQLQDYKAATNSYSQALKLTKDKAllaTLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGKLDQ 95
Cdd:COG5010  64 YNKLGDFEESLALLEQALQLDPNNP---ELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDE 140

                        90
                ....*....|...
gi 27477061  96 AFKDVQRCATLEP 108
Cdd:COG5010 141 AKAALQRALGTSP 153
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
42-110 1.38e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.61  E-value: 1.38e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27477061  42 LATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRN 110
Cdd:COG0457   7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD 75
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 13-110 2.87e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.95  E-value: 2.87e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061  13 GNRHFQLQDYKAATNSYSQALKLTKDKA----LLATLYrnraacgLKTESYVQAASDASRAIDINSSDIKALYRRCQALE 88
Cdd:COG2956 151 AELYLEQGDYDEAIEALEKALKLDPDCArallLLAELY-------LEQGDYEEAIAALERALEQDPDYLPALPRLAELYE 223

                        90       100
                ....*....|....*....|..
gi 27477061  89 HLGKLDQAFKDVQRCATLEPRN 110
Cdd:COG2956 224 KLGDPEEALELLRKALELDPSD 245
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 17-110 5.28e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 41.33  E-value: 5.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061  17 FQLQDYKAATNSYSQALKLTKDkalLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGKLDQA 96
Cdd:COG4783  49 LQLGDLDEAIVLLHEALELDPD---EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEA 125

                        90
                ....*....|....
gi 27477061  97 FKDVQRCATLEPRN 110
Cdd:COG4783 126 IAALEKALELDPDD 139
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 16-121 8.20e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.97  E-value: 8.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061  16 HFQLQDYKAATNSYSQALKLTKDKALLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIK---ALYRRCQALEHLGK 92
Cdd:COG1729   3 LLKAGDYDEAIAAFKAFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdALLKLGLSYLELGD 82

                        90       100
                ....*....|....*....|....*....
gi 27477061  93 LDQAFKDVQRCATLEPRNQNFQEMLRRLN 121
Cdd:COG1729  83 YDKARATLEELIKKYPDSEAAKEARARLA 111
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
21-112 1.48e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 41.05  E-value: 1.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061  21 DYKAATNSYSQALKLTKDKALLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGKLDQAFKDV 100
Cdd:COG4785  51 AALAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDF 130

                        90
                ....*....|..
gi 27477061 101 QRCATLEPRNQN 112
Cdd:COG4785 131 DRALELDPDYAY 142
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 1-110 3.10e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 41.12  E-value: 3.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061     1 MAEVEAVQLKEEGNRHFQLQDYKAATNSYSQALKLtkDKALLATlYRNRAACGLKTESYVQAASDASRAIDINSSDIKAL 80
Cdd:TIGR00990 326 LGEKEAIALNLRGTFKCLKGKHLEALADLSKSIEL--DPRVTQS-YIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIY 402

                          90       100       110
                  ....*....|....*....|....*....|
gi 27477061    81 YRRCQALEHLGKLDQAFKDVQRCATLEPRN 110
Cdd:TIGR00990 403 YHRAQLHFIKGEFAQAGKDYQKSIDLDPDF 432
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 13-120 3.37e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.48  E-value: 3.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477061  13 GNRHFQLQDYKAATNSYSQALKLTKDKALLatlYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGK 92
Cdd:COG2956 117 AEIYEQEGDWEKAIEVLERLLKLGPENAHA---YCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGD 193

                        90       100
                ....*....|....*....|....*...
gi 27477061  93 LDQAFKDVQRCATLEPRNQNFQEMLRRL 120
Cdd:COG2956 194 YEEAIAALERALEQDPDYLPALPRLAEL 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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