NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|28416956|ref|NP_783161|]
View 

GTPase IMAP family member 8 [Homo sapiens]

Protein Classification

GTPase IMAP family protein( domain architecture ID 10111261)

GTPase immunity-associated protein (IMAP) family protein may function as regulator of lymphocyte survival and homeostasis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 439-638 6.84e-85

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


:

Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 265.17  E-value: 6.84e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 439 LNIVLVGRSGTGKSATGNSILGSLVFTSRLRAQPVTKTSQSGRRTWDGQEVVVVDTPSfnqMLDVEKDPSRLEEEVKRCL 518
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPG---LFDTSVSPEQLSKEIIRCL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 519 SCCEKGDTFFVLVFQLGRFTEEDKTAVAKLEAIFGADFTKYAIMLFTRKEDLGAGNLEDFMKNSDnKALRRIFKKCGRRV 598
Cdd:cd01852  78 SLSAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSC-EALKRLLEKCGGRY 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 28416956 599 CAFNNKETGQAQETQVKALLTKVNDLRKEsgWSGYPHTQE 638
Cdd:cd01852 157 VAFNNKAKGREQEQQVKELLAKVEEMVRE--NGGKPYTNE 194
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 248-441 8.65e-82

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


:

Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 257.08  E-value: 8.65e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 248 LTVLLVGKRGAGKSAAGNSILGRQAFQTGFSEQSVTQSFLSESRSWRKKKVSIIDAPDISSLKNIDSEVRKHI------- 320
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIirclsls 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 321 CTGPHAFLLVTPLGFYTKNDEAVLSTIQNNFGEKFFEYMIILLTRKEDLGDQDLDTFLRNSNKALYGLIQKCKNRYSAFN 400
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSCEALKRLLEKCGGRYVAFN 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 28416956 401 YRATGEEEQRQADELLEKIESMVHQNGNKHCVFREKETLNI 441
Cdd:cd01852 161 NKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 11-203 4.84e-81

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


:

Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 255.15  E-value: 4.84e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956  11 LRLLLLGKCRSGKSATGNAILGKHVFKSKFSDQTVIKMCQRESWVLRERKVVVIDTPDLFSSIACAEDKQRNIQHCLELS 90
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956  91 APSLHALLLVIAIGHFTREDEETAKGIQQVFGAEARRHIIIVFTRKDDLGDDLLQDFIEKNKP-LKQLVQDYEGRYCIFN 169
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSCEaLKRLLEKCGGRYVAFN 160

                       170       180       190
                ....*....|....*....|....*....|....
gi 28416956 170 NKTNsKDEQITQVLELLRKVESLVNTNGGPYHVN 203
Cdd:cd01852 161 NKAK-GREQEQQVKELLAKVEEMVRENGGKPYTN 193
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 439-638 6.84e-85

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 265.17  E-value: 6.84e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 439 LNIVLVGRSGTGKSATGNSILGSLVFTSRLRAQPVTKTSQSGRRTWDGQEVVVVDTPSfnqMLDVEKDPSRLEEEVKRCL 518
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPG---LFDTSVSPEQLSKEIIRCL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 519 SCCEKGDTFFVLVFQLGRFTEEDKTAVAKLEAIFGADFTKYAIMLFTRKEDLGAGNLEDFMKNSDnKALRRIFKKCGRRV 598
Cdd:cd01852  78 SLSAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSC-EALKRLLEKCGGRY 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 28416956 599 CAFNNKETGQAQETQVKALLTKVNDLRKEsgWSGYPHTQE 638
Cdd:cd01852 157 VAFNNKAKGREQEQQVKELLAKVEEMVRE--NGGKPYTNE 194
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 248-441 8.65e-82

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 257.08  E-value: 8.65e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 248 LTVLLVGKRGAGKSAAGNSILGRQAFQTGFSEQSVTQSFLSESRSWRKKKVSIIDAPDISSLKNIDSEVRKHI------- 320
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIirclsls 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 321 CTGPHAFLLVTPLGFYTKNDEAVLSTIQNNFGEKFFEYMIILLTRKEDLGDQDLDTFLRNSNKALYGLIQKCKNRYSAFN 400
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSCEALKRLLEKCGGRYVAFN 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 28416956 401 YRATGEEEQRQADELLEKIESMVHQNGNKHCVFREKETLNI 441
Cdd:cd01852 161 NKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 11-203 4.84e-81

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 255.15  E-value: 4.84e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956  11 LRLLLLGKCRSGKSATGNAILGKHVFKSKFSDQTVIKMCQRESWVLRERKVVVIDTPDLFSSIACAEDKQRNIQHCLELS 90
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956  91 APSLHALLLVIAIGHFTREDEETAKGIQQVFGAEARRHIIIVFTRKDDLGDDLLQDFIEKNKP-LKQLVQDYEGRYCIFN 169
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSCEaLKRLLEKCGGRYVAFN 160

                       170       180       190
                ....*....|....*....|....*....|....
gi 28416956 170 NKTNsKDEQITQVLELLRKVESLVNTNGGPYHVN 203
Cdd:cd01852 161 NKAK-GREQEQQVKELLAKVEEMVRENGGKPYTN 193
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 439-655 7.13e-80

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 251.76  E-value: 7.13e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956   439 LNIVLVGRSGTGKSATGNSILGSLVFTSRLRAQPVTKTSQSGRRTWDGQEVVVVDTPSfnqMLDVEKDPSRLEEEVKRCL 518
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPG---LFDLSVSNDFISKEIIRCL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956   519 SCCEKGDTFFVLVFQLGRFTEEDKTAVAKLEAIFGADFTKYAIMLFTRKEDLGAGNLEDFMKNSDNKALRRIFKkcgrrv 598
Cdd:pfam04548  78 LLAEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDGCPEFLKEVLR------ 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 28416956   599 cafnnKETGQAQETQVKALLTKVNDLRKESGwsGYPHTQEnVSKLIKNVQEMSQAEK 655
Cdd:pfam04548 152 -----TADGEEKEEQVQQLLALVEAIVKENG--GKPYTND-LYEKIKEEGERLREQQ 200
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 11-215 4.71e-71

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 228.65  E-value: 4.71e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956    11 LRLLLLGKCRSGKSATGNAILGKHVFKSKFSDQTVIKMCQRESWVLRERKVVVIDTPDLFSSIACAEDKQRNIQHCLELS 90
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEIIRCLLLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956    91 APSLHALLLVIAIGHFTREDEETAKGIQQVFGAEARRHIIIVFTRKDDLGDDLLQDFIEK--NKPLKQLVQdyegrycif 168
Cdd:pfam04548  81 EPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDgcPEFLKEVLR--------- 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 28416956   169 nnkTNSKDEQITQVLELLRKVESLVNTNGGPYHVN-----FKTEGSRFQDCV 215
Cdd:pfam04548 152 ---TADGEEKEEQVQQLLALVEAIVKENGGKPYTNdlyekIKEEGERLREQQ 200
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 248-430 1.13e-70

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 227.88  E-value: 1.13e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956   248 LTVLLVGKRGAGKSAAGNSILGRQAFQTGFSEQSVTQSFLSESRSWRKKKVSIIDAPDISSLKNIDSEVRKHI------- 320
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEIircllla 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956   321 CTGPHAFLLVTPLGFYTKNDEAVLSTIQNNFGEKFFEYMIILLTRKEDLGDQDLDTFLRN-SNKALYGLIQKcknrysaf 399
Cdd:pfam04548  81 EPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDgCPEFLKEVLRT-------- 152

                         170       180       190
                  ....*....|....*....|....*....|.
gi 28416956   400 nyrATGEEEQRQADELLEKIESMVHQNGNKH 430
Cdd:pfam04548 153 ---ADGEEKEEQVQQLLALVEAIVKENGGKP 180
YeeP COG3596
Predicted GTPase [General function prediction only];
409-521 3.55e-06

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 49.38  E-value: 3.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 409 QRQADELLEKIESMVhqngnkhcvfREKETLNIVLVGRSGTGKSATGNSILGSLVF-TSRLRaqPVTKTSQSGR-RTWDG 486
Cdd:COG3596  20 QVLRELLAEALERLL----------VELPPPVIALVGKTGAGKSSLINALFGAEVAeVGVGR--PCTREIQRYRlESDGL 87

                        90       100       110
                ....*....|....*....|....*....|....*
gi 28416956 487 QEVVVVDTPSFNQmldvEKDPSRLEEEVKRCLSCC 521
Cdd:COG3596  88 PGLVLLDTPGLGE----VNERDREYRELRELLPEA 118
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 410-495 4.73e-06

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 49.95  E-value: 4.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956   410 RQADEL--LEKIESMVHQ---NGNKHCVFrekeTLNIVLVGRSGTGKSATGNSILGSLVFTSRlRAQPVTKTSQSGRRTW 484
Cdd:TIGR00993  89 RQGGGAfsLDAAKAMAEQleaEGQDPLDF----SLNILVLGKSGVGKSATINSIFGEVKFSTD-AFGMGTTSVQEIEGLV 163

                          90
                  ....*....|.
gi 28416956   485 DGQEVVVVDTP 495
Cdd:TIGR00993 164 QGVKIRVIDTP 174
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 233-364 8.76e-06

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 49.18  E-value: 8.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956   233 QLQSTGpeQNPGTSELTVLLVGKRGAGKSAAGNSILGRQAFQT---GFSEQSVTQSflseSRSWRKKKVSIIDAP----- 304
Cdd:TIGR00993 106 QLEAEG--QDPLDFSLNILVLGKSGVGKSATINSIFGEVKFSTdafGMGTTSVQEI----EGLVQGVKIRVIDTPglkss 179

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28416956   305 --DISSLKNIDSEVRKHICTGPHAFLL-VTPLGFYTK--NDEAVLSTIQNNFGEKFFEYMIILLT 364
Cdd:TIGR00993 180 asDQSKNEKILSSVKKFIKKNPPDIVLyVDRLDMQTRdsNDLPLLRTITDVLGPSIWFNAIVTLT 244
YeeP COG3596
Predicted GTPase [General function prediction only];
10-134 1.23e-05

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 47.84  E-value: 1.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956  10 ELRLLLLGKCRSGKSATGNAIlgkhvFKSKFSDQTVIKMCQRESWVLR-----ERKVVVIDTPDLFSSIAcAEDKQRNIQ 84
Cdd:COG3596  39 PPVIALVGKTGAGKSSLINAL-----FGAEVAEVGVGRPCTREIQRYRlesdgLPGLVLLDTPGLGEVNE-RDREYRELR 112

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 28416956  85 HCLelsaPSLHALLLVIAIG-HFTREDEETAKGIQQVFgaeARRHIIIVFT 134
Cdd:COG3596 113 ELL----PEADLILWVVKADdRALATDEEFLQALRAQY---PDPPVLVVLT 156
YeeP COG3596
Predicted GTPase [General function prediction only];
230-332 7.47e-03

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 38.98  E-value: 7.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 230 RERQLQSTGPEQNPGTSELTVLLVGKRGAGKSAAGNSILGRQAFQTGFSEQS--VTQSFLSESRSWRkkKVSIIDAPDIS 307
Cdd:COG3596  22 LRELLAEALERLLVELPPPVIALVGKTGAGKSSLINALFGAEVAEVGVGRPCtrEIQRYRLESDGLP--GLVLLDTPGLG 99

                        90       100
                ....*....|....*....|....*...
gi 28416956 308 SLKNID---SEVRKHICTgPHAFLLVTP 332
Cdd:COG3596 100 EVNERDreyRELRELLPE-ADLILWVVK 126
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 439-638 6.84e-85

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 265.17  E-value: 6.84e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 439 LNIVLVGRSGTGKSATGNSILGSLVFTSRLRAQPVTKTSQSGRRTWDGQEVVVVDTPSfnqMLDVEKDPSRLEEEVKRCL 518
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPG---LFDTSVSPEQLSKEIIRCL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 519 SCCEKGDTFFVLVFQLGRFTEEDKTAVAKLEAIFGADFTKYAIMLFTRKEDLGAGNLEDFMKNSDnKALRRIFKKCGRRV 598
Cdd:cd01852  78 SLSAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSC-EALKRLLEKCGGRY 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 28416956 599 CAFNNKETGQAQETQVKALLTKVNDLRKEsgWSGYPHTQE 638
Cdd:cd01852 157 VAFNNKAKGREQEQQVKELLAKVEEMVRE--NGGKPYTNE 194
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 248-441 8.65e-82

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 257.08  E-value: 8.65e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 248 LTVLLVGKRGAGKSAAGNSILGRQAFQTGFSEQSVTQSFLSESRSWRKKKVSIIDAPDISSLKNIDSEVRKHI------- 320
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIirclsls 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 321 CTGPHAFLLVTPLGFYTKNDEAVLSTIQNNFGEKFFEYMIILLTRKEDLGDQDLDTFLRNSNKALYGLIQKCKNRYSAFN 400
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSCEALKRLLEKCGGRYVAFN 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 28416956 401 YRATGEEEQRQADELLEKIESMVHQNGNKHCVFREKETLNI 441
Cdd:cd01852 161 NKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 11-203 4.84e-81

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 255.15  E-value: 4.84e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956  11 LRLLLLGKCRSGKSATGNAILGKHVFKSKFSDQTVIKMCQRESWVLRERKVVVIDTPDLFSSIACAEDKQRNIQHCLELS 90
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956  91 APSLHALLLVIAIGHFTREDEETAKGIQQVFGAEARRHIIIVFTRKDDLGDDLLQDFIEKNKP-LKQLVQDYEGRYCIFN 169
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSCEaLKRLLEKCGGRYVAFN 160

                       170       180       190
                ....*....|....*....|....*....|....
gi 28416956 170 NKTNsKDEQITQVLELLRKVESLVNTNGGPYHVN 203
Cdd:cd01852 161 NKAK-GREQEQQVKELLAKVEEMVRENGGKPYTN 193
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 439-655 7.13e-80

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 251.76  E-value: 7.13e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956   439 LNIVLVGRSGTGKSATGNSILGSLVFTSRLRAQPVTKTSQSGRRTWDGQEVVVVDTPSfnqMLDVEKDPSRLEEEVKRCL 518
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPG---LFDLSVSNDFISKEIIRCL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956   519 SCCEKGDTFFVLVFQLGRFTEEDKTAVAKLEAIFGADFTKYAIMLFTRKEDLGAGNLEDFMKNSDNKALRRIFKkcgrrv 598
Cdd:pfam04548  78 LLAEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDGCPEFLKEVLR------ 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 28416956   599 cafnnKETGQAQETQVKALLTKVNDLRKESGwsGYPHTQEnVSKLIKNVQEMSQAEK 655
Cdd:pfam04548 152 -----TADGEEKEEQVQQLLALVEAIVKENG--GKPYTND-LYEKIKEEGERLREQQ 200
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 11-215 4.71e-71

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 228.65  E-value: 4.71e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956    11 LRLLLLGKCRSGKSATGNAILGKHVFKSKFSDQTVIKMCQRESWVLRERKVVVIDTPDLFSSIACAEDKQRNIQHCLELS 90
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEIIRCLLLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956    91 APSLHALLLVIAIGHFTREDEETAKGIQQVFGAEARRHIIIVFTRKDDLGDDLLQDFIEK--NKPLKQLVQdyegrycif 168
Cdd:pfam04548  81 EPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDgcPEFLKEVLR--------- 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 28416956   169 nnkTNSKDEQITQVLELLRKVESLVNTNGGPYHVN-----FKTEGSRFQDCV 215
Cdd:pfam04548 152 ---TADGEEKEEQVQQLLALVEAIVKENGGKPYTNdlyekIKEEGERLREQQ 200
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 248-430 1.13e-70

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 227.88  E-value: 1.13e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956   248 LTVLLVGKRGAGKSAAGNSILGRQAFQTGFSEQSVTQSFLSESRSWRKKKVSIIDAPDISSLKNIDSEVRKHI------- 320
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEIircllla 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956   321 CTGPHAFLLVTPLGFYTKNDEAVLSTIQNNFGEKFFEYMIILLTRKEDLGDQDLDTFLRN-SNKALYGLIQKcknrysaf 399
Cdd:pfam04548  81 EPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDgCPEFLKEVLRT-------- 152

                         170       180       190
                  ....*....|....*....|....*....|.
gi 28416956   400 nyrATGEEEQRQADELLEKIESMVHQNGNKH 430
Cdd:pfam04548 153 ---ADGEEKEEQVQQLLALVEAIVKENGGKP 180
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 231-364 6.13e-10

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 60.02  E-value: 6.13e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 231 ERQLQSTGPEQNpgTSELTVLLVGKRGAGKSAAGNSILGRQAFQTGfSEQSVTQSFLSESRSWRKKKVSIIDAPDISSL- 309
Cdd:cd01853  17 LHELEAKLKKEL--DFSLTILVLGKTGVGKSSTINSIFGERKVSVS-AFQSETLRPREVSRTVDGFKLNIIDTPGLLESq 93

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28416956 310 -----KNIDSEVRKHI--CTgPHAFLLVTPLGFYT--KNDEAVLSTIQNNFGEKFFEYMIILLT 364
Cdd:cd01853  94 dqrvnRKILSIIKRFLkkKT-IDVVLYVDRLDMYRvdNLDVPLLRAITDSFGPSIWRNAIVVLT 156
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 436-565 3.92e-08

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 54.63  E-value: 3.92e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 436 KETLNIVLVGRSGTGKSATGNSILGslvftsrlraQPVTKTS--QSG-------RRTWDGQEVVVVDTPSFNQMLDVEKD 506
Cdd:cd01853  29 DFSLTILVLGKTGVGKSSTINSIFG----------ERKVSVSafQSEtlrprevSRTVDGFKLNIIDTPGLLESQDQRVN 98

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 28416956 507 pSRLEEEVKRCLSCCEKGDTFFVLVFQLGRFTEEDKTAVAKLEAIFGADFTKYAIMLFT 565
Cdd:cd01853  99 -RKILSIIKRFLKKKTIDVVLYVDRLDMYRVDNLDVPLLRAITDSFGPSIWRNAIVVLT 156
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 8-134 9.85e-08

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 53.48  E-value: 9.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956   8 MSELRLLLLGKCRSGKSATGNAILGKHVFK-SKF-SDQTVIKMCQReswVLRERKVVVIDTPDLFSSIACAEDKQRNIQH 85
Cdd:cd01853  29 DFSLTILVLGKTGVGKSSTINSIFGERKVSvSAFqSETLRPREVSR---TVDGFKLNIIDTPGLLESQDQRVNRKILSII 105

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 28416956  86 CLELSAPSLHALLLVIAIGHFTRE--DEETAKGIQQVFGAEARRHIIIVFT 134
Cdd:cd01853 106 KRFLKKKTIDVVLYVDRLDMYRVDnlDVPLLRAITDSFGPSIWRNAIVVLT 156
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 14-186 7.95e-07

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 49.38  E-value: 7.95e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956  14 LLLGKCRSGKSATGNAILGKHVFK-SKFSDQTVikMCQRESWVLR--ERKVVVIDTPDLFSSIAcaedkqRNIQHCLELS 90
Cdd:cd00882   1 VVVGRGGVGKSSLLNALLGGEVGEvSDVPGTTR--DPDVYVKELDkgKVKLVLVDTPGLDEFGG------LGREELARLL 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956  91 APSLHALLLVIAIGhfTREDEETAKGIQQVFGAEARRHIIIVFTRKDDLGDDLlqdfIEKNKPLKQLVQDYEGRYCIFNN 170
Cdd:cd00882  73 LRGADLILLVVDST--DRESEEDAKLLILRRLRKEGIPIILVGNKIDLLEERE----VEELLRLEELAKILGVPVFEVSA 146

                       170
                ....*....|....*.
gi 28416956 171 KTNskdEQITQVLELL 186
Cdd:cd00882 147 KTG---EGVDELFEKL 159
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 440-495 1.03e-06

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 47.61  E-value: 1.03e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 28416956   440 NIVLVGRSGTGKSATGNSILGSLVFTSrlrAQP-VTKTSQSGRRTWDGQEVVVVDTP 495
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAKAIVS---DYPgTTRDPNEGRLELKGKQIILVDTP 54
YeeP COG3596
Predicted GTPase [General function prediction only];
409-521 3.55e-06

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 49.38  E-value: 3.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 409 QRQADELLEKIESMVhqngnkhcvfREKETLNIVLVGRSGTGKSATGNSILGSLVF-TSRLRaqPVTKTSQSGR-RTWDG 486
Cdd:COG3596  20 QVLRELLAEALERLL----------VELPPPVIALVGKTGAGKSSLINALFGAEVAeVGVGR--PCTREIQRYRlESDGL 87

                        90       100       110
                ....*....|....*....|....*....|....*
gi 28416956 487 QEVVVVDTPSFNQmldvEKDPSRLEEEVKRCLSCC 521
Cdd:COG3596  88 PGLVLLDTPGLGE----VNERDREYRELRELLPEA 118
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 410-495 4.73e-06

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 49.95  E-value: 4.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956   410 RQADEL--LEKIESMVHQ---NGNKHCVFrekeTLNIVLVGRSGTGKSATGNSILGSLVFTSRlRAQPVTKTSQSGRRTW 484
Cdd:TIGR00993  89 RQGGGAfsLDAAKAMAEQleaEGQDPLDF----SLNILVLGKSGVGKSATINSIFGEVKFSTD-AFGMGTTSVQEIEGLV 163

                          90
                  ....*....|.
gi 28416956   485 DGQEVVVVDTP 495
Cdd:TIGR00993 164 QGVKIRVIDTP 174
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 233-364 8.76e-06

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 49.18  E-value: 8.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956   233 QLQSTGpeQNPGTSELTVLLVGKRGAGKSAAGNSILGRQAFQT---GFSEQSVTQSflseSRSWRKKKVSIIDAP----- 304
Cdd:TIGR00993 106 QLEAEG--QDPLDFSLNILVLGKSGVGKSATINSIFGEVKFSTdafGMGTTSVQEI----EGLVQGVKIRVIDTPglkss 179

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28416956   305 --DISSLKNIDSEVRKHICTGPHAFLL-VTPLGFYTK--NDEAVLSTIQNNFGEKFFEYMIILLT 364
Cdd:TIGR00993 180 asDQSKNEKILSSVKKFIKKNPPDIVLyVDRLDMQTRdsNDLPLLRTITDVLGPSIWFNAIVTLT 244
YeeP COG3596
Predicted GTPase [General function prediction only];
10-134 1.23e-05

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 47.84  E-value: 1.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956  10 ELRLLLLGKCRSGKSATGNAIlgkhvFKSKFSDQTVIKMCQRESWVLR-----ERKVVVIDTPDLFSSIAcAEDKQRNIQ 84
Cdd:COG3596  39 PPVIALVGKTGAGKSSLINAL-----FGAEVAEVGVGRPCTREIQRYRlesdgLPGLVLLDTPGLGEVNE-RDREYRELR 112

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 28416956  85 HCLelsaPSLHALLLVIAIG-HFTREDEETAKGIQQVFgaeARRHIIIVFT 134
Cdd:COG3596 113 ELL----PEADLILWVVKADdRALATDEEFLQALRAQY---PDPPVLVVLT 156
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 442-541 7.47e-05

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 43.60  E-value: 7.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 442 VLVGRSGTGKSATGNSILGSLVFTSRlRAQPVTKTSQSGRRTWDGQE--VVVVDTPSFnqmldVEKDPSRLEEEVKRCLS 519
Cdd:cd00882   1 VVVGRGGVGKSSLLNALLGGEVGEVS-DVPGTTRDPDVYVKELDKGKvkLVLVDTPGL-----DEFGGLGREELARLLLR 74

                        90       100
                ....*....|....*....|...
gi 28416956 520 CCEkgdtFFVLVFQLG-RFTEED 541
Cdd:cd00882  75 GAD----LILLVVDSTdRESEED 93
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 251-373 2.42e-04

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 42.06  E-value: 2.42e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 251 LLVGKRGAGKSAAGNSILGRQAFQTGfSEQSVTQSFLSESRSWRKKKVS--IIDAPDISSLKNIDSEVR-KHICTGPHAF 327
Cdd:cd00882   1 VVVGRGGVGKSSLLNALLGGEVGEVS-DVPGTTRDPDVYVKELDKGKVKlvLVDTPGLDEFGGLGREELaRLLLRGADLI 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 28416956 328 LLVTPLGFYTKNDEAVLSTIQNNFGEKffEYMIILLTrKEDLGDQD 373
Cdd:cd00882  80 LLVVDSTDRESEEDAKLLILRRLRKEG--IPIILVGN-KIDLLEER 122
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
 226-364 7.87e-04

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 42.19  E-value: 7.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956   226 PQGPRERQLQSTGPEQNPGTSELTVLLVGKRGAGKSAAGNSILG-RQAFQTGFSEQSVTQSFLSESRSwrKKKVSIIDAP 304
Cdd:TIGR00991  17 PPATQTKLLELLGKLKEEDVSSLTILVMGKGGVGKSSTVNSIIGeRIATVSAFQSEGLRPMMVSRTRA--GFTLNIIDTP 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28416956   305 DISSLKNIDSEVRKHIctgpHAFLL---------VTPLGFYTKN--DEAVLSTIQNNFGEKFFEYMIILLT 364
Cdd:TIGR00991  95 GLIEGGYINDQAVNII----KRFLLgktidvllyVDRLDAYRVDtlDGQVIRAITDSFGKDIWRKSLVVLT 161
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 12-135 1.96e-03

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 38.37  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956    12 RLLLLGKCRSGKSATGNAILGKHVFKSKFSDQTviKMCQRESWVLRERKVVVIDTPDLFSSIACAEDKQRNIqhcleLSA 91
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAKAIVSDYPGTT--RDPNEGRLELKGKQIILVDTPGLIEGASEGEGLGRAF-----LAI 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 28416956    92 PSLHALLLVI-AIGHFTREDEETAKgiqqvFGAEARRHIIIVFTR 135
Cdd:pfam01926  74 IEADLILFVVdSEEGITPLDEELLE-----LLRENKKPIILVLNK 113
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
 15-135 3.01e-03

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 38.77  E-value: 3.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956  15 LLGKCRSGKSATGNAILGKHVFK-SKFSDQTviKMCQRESWVLRE-RKVVVIDTPDLFSSIACA-EDKQRNIQHclelsA 91
Cdd:cd00880   2 IFGRPNVGKSSLLNALLGQNVGIvSPIPGTT--RDPVRKEWELLPlGPVVLIDTPGLDEEGGLGrERVEEARQV-----A 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 28416956  92 PSLHALLLVIAIGHFTREDEETakgIQQVFGAEARrhIIIVFTR 135
Cdd:cd00880  75 DRADLVLLVVDSDLTPVEEEAK---LGLLRERGKP--VLLVLNK 113
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
 250-401 3.61e-03

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 38.51  E-value: 3.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956   250 VLLVGKRGAGKSAAGNSILGRQAFQTGFSEQsVTQSFLSESRSWR--KKKVSIIDAPDISSlkniDSEVRKHICTGPHAF 327
Cdd:TIGR00231   4 IVIVGHPNVGKSTLLNSLLGNKGSITEYYPG-TTRNYVTTVIEEDgkTYKFNLLDTAGQED----YDAIRRLYYPQVERS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956   328 LLVTPLGFYTKN-DEAVLSTIQNNFGEKFFEYMIILLTRKEDLGDQDLDTFLRNSNKALYGLIQ------KCKNRYSAFN 400
Cdd:TIGR00231  79 LRVFDIVILVLDvEEILEKQTKEIIHHADSGVPIILVGNKIDLKDADLKTHVASEFAKLNGEPIiplsaeTGKNIDSAFK 158


                  .
gi 28416956   401 Y 401
Cdd:TIGR00231 159 I 159
YeeP COG3596
Predicted GTPase [General function prediction only];
230-332 7.47e-03

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 38.98  E-value: 7.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416956 230 RERQLQSTGPEQNPGTSELTVLLVGKRGAGKSAAGNSILGRQAFQTGFSEQS--VTQSFLSESRSWRkkKVSIIDAPDIS 307
Cdd:COG3596  22 LRELLAEALERLLVELPPPVIALVGKTGAGKSSLINALFGAEVAEVGVGRPCtrEIQRYRLESDGLP--GLVLLDTPGLG 99

                        90       100
                ....*....|....*....|....*...
gi 28416956 308 SLKNID---SEVRKHICTgPHAFLLVTP 332
Cdd:COG3596 100 EVNERDreyRELRELLPE-ADLILWVVK 126
CDC_Septin cd01850
CDC/Septin GTPase family; Septins are a conserved family of GTP-binding proteins associated ...
 438-497 8.96e-03

CDC/Septin GTPase family; Septins are a conserved family of GTP-binding proteins associated with diverse processes in dividing and non-dividing cells. They were first discovered in the budding yeast S. cerevisiae as a set of genes (CDC3, CDC10, CDC11 and CDC12) required for normal bud morphology. Septins are also present in metazoan cells, where they are required for cytokinesis in some systems, and implicated in a variety of other processes involving organization of the cell cortex and exocytosis. In humans, 12 septin genes generate dozens of polypeptides, many of which comprise heterooligomeric complexes. Since septin mutants are commonly defective in cytokinesis and formation of the neck formation of the neck filaments/septin rings, septins have been considered to be the primary constituents of the neck filaments. Septins belong to the GTPase superfamily for their conserved GTPase motifs and enzymatic activities.


Pssm-ID: 206649  Cd Length: 275  Bit Score: 38.68  E-value: 8.96e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28416956 438 TLNIVLVGRSGTGKSATGNSILGSLVFTSR---LRAQPVTKTSQSGRRTWDGQE------VVVVDTPSF 497
Cdd:cd01850   4 QFNIMVVGESGLGKSTFINTLFGTKLYPSKyppAPGEHITKTVEIKISKAELEEngvklkLTVIDTPGF 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH