NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|28559025|ref|NP_783852|]
View 

interleukin-5 receptor subunit alpha isoform 3 precursor [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 229438)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to Homo sapiens interleukin-5 receptor subunit alpha and interferon gamma receptor 2

PubMed:  8981327

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 131-236 4.95e-23

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09240:

Pssm-ID: 473895  Cd Length: 96  Bit Score: 91.32  E-value: 4.95e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559025   131 NLTCTTNTTednysrlrsyqVSLHCTWLVGTDAPEDTQYFLYYRY--GSWTEECQEYSKDTlGRNIACWFPRTFILSKGR 208
Cdd:pfam09240   1 DLTCFIHNP-----------SNLSCEWKPGPNAPPDTNYVLYVRKspLGPVLQCQYYIRDD-GTRIGCQFDDLEGLSSSF 68

                          90       100
                  ....*....|....*....|....*...
gi 28559025   209 DWLAVLVNGSSKHSAIRPFDQLFALHAI 236
Cdd:pfam09240  69 HQVYICVNGSSSAGPIRSSDQTFQLQNI 96
 
Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 131-236 4.95e-23

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 91.32  E-value: 4.95e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559025   131 NLTCTTNTTednysrlrsyqVSLHCTWLVGTDAPEDTQYFLYYRY--GSWTEECQEYSKDTlGRNIACWFPRTFILSKGR 208
Cdd:pfam09240   1 DLTCFIHNP-----------SNLSCEWKPGPNAPPDTNYVLYVRKspLGPVLQCQYYIRDD-GTRIGCQFDDLEGLSSSF 68

                          90       100
                  ....*....|....*....|....*...
gi 28559025   209 DWLAVLVNGSSKHSAIRPFDQLFALHAI 236
Cdd:pfam09240  69 HQVYICVNGSSSAGPIRSSDQTFQLQNI 96
 
Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 131-236 4.95e-23

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 91.32  E-value: 4.95e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559025   131 NLTCTTNTTednysrlrsyqVSLHCTWLVGTDAPEDTQYFLYYRY--GSWTEECQEYSKDTlGRNIACWFPRTFILSKGR 208
Cdd:pfam09240   1 DLTCFIHNP-----------SNLSCEWKPGPNAPPDTNYVLYVRKspLGPVLQCQYYIRDD-GTRIGCQFDDLEGLSSSF 68

                          90       100
                  ....*....|....*....|....*...
gi 28559025   209 DWLAVLVNGSSKHSAIRPFDQLFALHAI 236
Cdd:pfam09240  69 HQVYICVNGSSSAGPIRSSDQTFQLQNI 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH