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Conserved domains on  [gi|194394221|ref|NP_796125|]
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intermembrane lipid transfer protein VPS13B [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 2-94 9.42e-30

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


:

Pssm-ID: 463646  Cd Length: 116  Bit Score: 116.13  E-value: 9.42e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221     2 LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEqELKLPFTFLSGHIHELRIHVPWTKLGSEPVVI 81
Cdd:pfam12624    1 LESLVASLLNRYLGEYVENLDPDQLKVGLWSGDVVLENLKLKKEALD-KLDLPIEVKSGHIGKLTLKIPWTNLKSEPVVI 79

                           90
                   ....*....|...
gi 194394221    82 TINTMECILKLKD 94
Cdd:pfam12624   80 EIEDVYLLAVPKD 92
VPS13_C super family cl25193
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
 3557-3703 5.22e-25

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


The actual alignment was detected with superfamily member pfam16909:

Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 104.55  E-value: 5.22e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221  3557 LRKLLIQPVNLLISI--------------HASLKLYIAS--------DHTPLSFSVFERGPVFTTARQLVHALAMHYAAG 3614
Cdd:pfam16909    4 FELLHLQPIKLHLSFsrservnleeslekSNPLSFLLNSlgmtlgniDDAPIKLNALELENVFVTLPQLQNRIQKHYSQQ 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221  3615 ALFRAGWVVGSLEILGSPASLVRSIGNGISDFFRLPYEGLTRGPGAFVSGVSRGTTSFVKHISKGALTSITNLATSLARN 3694
Cdd:pfam16909   84 FLYQLYKILGSLDFLGNPVGLFNNISSGVKDFFYEPYQGLIQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSKITGSIGKG 163


                   ....*....
gi 194394221  3695 MGRLSLDEE 3703
Cdd:pfam16909  164 LAALTMDKQ 172
ATG_C super family cl07826
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 3716-3809 3.34e-05

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


The actual alignment was detected with superfamily member pfam09333:

Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 45.19  E-value: 3.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221  3716 PESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSetqasaghkAKGVISGVGKGIMGVFTKPIGGAAELVSQTgyg 3795
Cdd:pfam09333    8 PEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKG---------AGGAAKAVLRAVPVAVLRPAIGATEAVSKT--- 75

                           90
                   ....*....|....
gi 194394221  3796 iLHGAGLSQLPKQR 3809
Cdd:pfam09333   76 -LLGVRNQLDPENR 88
SHR-BD super family cl05933
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2605-2685 1.22e-04

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


The actual alignment was detected with superfamily member pfam06650:

Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 46.91  E-value: 1.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221  2605 FVICNDTQETLRFGQVDTDENILLAS-----LHSHqyswRSHKSPQLLhICIEGwGNWRWSEPFTVDHAGTFIRTIQYKG 2679
Cdd:pfam06650  120 FIIKNKLPEDLEIREPGSSKIISLPPgelipLHWL----RNVEEKQLC-IRFPG-SNSQWSSPFNISDVGSTYVKVRRQN 193


                   ....*.
gi 194394221  2680 RTASLI 2685
Cdd:pfam06650  194 SGQKLL 199
 
Name Accession Description Interval E-value
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 2-94 9.42e-30

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 116.13  E-value: 9.42e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221     2 LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEqELKLPFTFLSGHIHELRIHVPWTKLGSEPVVI 81
Cdd:pfam12624    1 LESLVASLLNRYLGEYVENLDPDQLKVGLWSGDVVLENLKLKKEALD-KLDLPIEVKSGHIGKLTLKIPWTNLKSEPVVI 79

                           90
                   ....*....|...
gi 194394221    82 TINTMECILKLKD 94
Cdd:pfam12624   80 EIEDVYLLAVPKD 92
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
 3557-3703 5.22e-25

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 104.55  E-value: 5.22e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221  3557 LRKLLIQPVNLLISI--------------HASLKLYIAS--------DHTPLSFSVFERGPVFTTARQLVHALAMHYAAG 3614
Cdd:pfam16909    4 FELLHLQPIKLHLSFsrservnleeslekSNPLSFLLNSlgmtlgniDDAPIKLNALELENVFVTLPQLQNRIQKHYSQQ 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221  3615 ALFRAGWVVGSLEILGSPASLVRSIGNGISDFFRLPYEGLTRGPGAFVSGVSRGTTSFVKHISKGALTSITNLATSLARN 3694
Cdd:pfam16909   84 FLYQLYKILGSLDFLGNPVGLFNNISSGVKDFFYEPYQGLIQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSKITGSIGKG 163


                   ....*....
gi 194394221  3695 MGRLSLDEE 3703
Cdd:pfam16909  164 LAALTMDKQ 172
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3596-3796 1.79e-16

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 87.63  E-value: 1.79e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221 3596 VFTTARQLVHALAMHYAAGALFRAGWVVGSLEILGSPASLVRSIGNGISDFFRLPYEG--LTRGPGAFVSGVSRGTTSFV 3673
Cdd:COG5043  2215 ARVSLPELFDLIASHYLQQVEYQIYKILGSADFLGNPVGLFETVSSGVSDLFYEPYQGrfLVDNSQEWGIGIAKGGNSFI 2294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221 3674 KHISKGALTSITNLATSLARNMGRLSLDEEHYN-RQEEWRRQLPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKT 3752
Cdd:COG5043  2295 KKTIYGVSDSVSKFTGSISKGLSLVTSDPELQSsRRLVRRRNRPKGSVYGVTAGATSLYDSTSSGEKGLALEPIIGAATN 2374

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 194394221 3753 SetqasaghkAKGVISGVGKGIMGVFTKPIGGAAELVSQTGYGI 3796
Cdd:COG5043  2375 G---------ASGFVKGLGKGILGLETKPLVGFLDLTSNDSEGI 2409
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
1-83 3.69e-11

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 69.91  E-value: 3.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221    1 MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQeLKLPFTFLSGHIHELRIHVPWTKLGSEPVV 80
Cdd:COG5043     1 MLEGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDK-LGLPIEVTSGLIGTLTLEIPWSSLKNKPVE 79


                  ...
gi 194394221   81 ITI 83
Cdd:COG5043    80 IYI 82
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 3716-3809 3.34e-05

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 45.19  E-value: 3.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221  3716 PESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSetqasaghkAKGVISGVGKGIMGVFTKPIGGAAELVSQTgyg 3795
Cdd:pfam09333    8 PEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKG---------AGGAAKAVLRAVPVAVLRPAIGATEAVSKT--- 75

                           90
                   ....*....|....
gi 194394221  3796 iLHGAGLSQLPKQR 3809
Cdd:pfam09333   76 -LLGVRNQLDPENR 88
SHR-BD pfam06650
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2605-2685 1.22e-04

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 46.91  E-value: 1.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221  2605 FVICNDTQETLRFGQVDTDENILLAS-----LHSHqyswRSHKSPQLLhICIEGwGNWRWSEPFTVDHAGTFIRTIQYKG 2679
Cdd:pfam06650  120 FIIKNKLPEDLEIREPGSSKIISLPPgelipLHWL----RNVEEKQLC-IRFPG-SNSQWSSPFNISDVGSTYVKVRRQN 193


                   ....*.
gi 194394221  2680 RTASLI 2685
Cdd:pfam06650  194 SGQKLL 199
 
Name Accession Description Interval E-value
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 2-94 9.42e-30

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 116.13  E-value: 9.42e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221     2 LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEqELKLPFTFLSGHIHELRIHVPWTKLGSEPVVI 81
Cdd:pfam12624    1 LESLVASLLNRYLGEYVENLDPDQLKVGLWSGDVVLENLKLKKEALD-KLDLPIEVKSGHIGKLTLKIPWTNLKSEPVVI 79

                           90
                   ....*....|...
gi 194394221    82 TINTMECILKLKD 94
Cdd:pfam12624   80 EIEDVYLLAVPKD 92
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
 3557-3703 5.22e-25

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 104.55  E-value: 5.22e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221  3557 LRKLLIQPVNLLISI--------------HASLKLYIAS--------DHTPLSFSVFERGPVFTTARQLVHALAMHYAAG 3614
Cdd:pfam16909    4 FELLHLQPIKLHLSFsrservnleeslekSNPLSFLLNSlgmtlgniDDAPIKLNALELENVFVTLPQLQNRIQKHYSQQ 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221  3615 ALFRAGWVVGSLEILGSPASLVRSIGNGISDFFRLPYEGLTRGPGAFVSGVSRGTTSFVKHISKGALTSITNLATSLARN 3694
Cdd:pfam16909   84 FLYQLYKILGSLDFLGNPVGLFNNISSGVKDFFYEPYQGLIQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSKITGSIGKG 163


                   ....*....
gi 194394221  3695 MGRLSLDEE 3703
Cdd:pfam16909  164 LAALTMDKQ 172
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3596-3796 1.79e-16

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 87.63  E-value: 1.79e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221 3596 VFTTARQLVHALAMHYAAGALFRAGWVVGSLEILGSPASLVRSIGNGISDFFRLPYEG--LTRGPGAFVSGVSRGTTSFV 3673
Cdd:COG5043  2215 ARVSLPELFDLIASHYLQQVEYQIYKILGSADFLGNPVGLFETVSSGVSDLFYEPYQGrfLVDNSQEWGIGIAKGGNSFI 2294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221 3674 KHISKGALTSITNLATSLARNMGRLSLDEEHYN-RQEEWRRQLPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKT 3752
Cdd:COG5043  2295 KKTIYGVSDSVSKFTGSISKGLSLVTSDPELQSsRRLVRRRNRPKGSVYGVTAGATSLYDSTSSGEKGLALEPIIGAATN 2374

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 194394221 3753 SetqasaghkAKGVISGVGKGIMGVFTKPIGGAAELVSQTGYGI 3796
Cdd:COG5043  2375 G---------ASGFVKGLGKGILGLETKPLVGFLDLTSNDSEGI 2409
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
1-83 3.69e-11

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 69.91  E-value: 3.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221    1 MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQeLKLPFTFLSGHIHELRIHVPWTKLGSEPVV 80
Cdd:COG5043     1 MLEGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDK-LGLPIEVTSGLIGTLTLEIPWSSLKNKPVE 79


                  ...
gi 194394221   81 ITI 83
Cdd:COG5043    80 IYI 82
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 3716-3809 3.34e-05

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 45.19  E-value: 3.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221  3716 PESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSetqasaghkAKGVISGVGKGIMGVFTKPIGGAAELVSQTgyg 3795
Cdd:pfam09333    8 PEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKG---------AGGAAKAVLRAVPVAVLRPAIGATEAVSKT--- 75

                           90
                   ....*....|....
gi 194394221  3796 iLHGAGLSQLPKQR 3809
Cdd:pfam09333   76 -LLGVRNQLDPENR 88
SHR-BD pfam06650
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2605-2685 1.22e-04

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 46.91  E-value: 1.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394221  2605 FVICNDTQETLRFGQVDTDENILLAS-----LHSHqyswRSHKSPQLLhICIEGwGNWRWSEPFTVDHAGTFIRTIQYKG 2679
Cdd:pfam06650  120 FIIKNKLPEDLEIREPGSSKIISLPPgelipLHWL----RNVEEKQLC-IRFPG-SNSQWSSPFNISDVGSTYVKVRRQN 193


                   ....*.
gi 194394221  2680 RTASLI 2685
Cdd:pfam06650  194 SGQKLL 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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