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Conserved domains on  [gi|259155417|ref|NP_803180|]
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A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform 1 preproprotein [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 255-461 7.74e-111

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


:

Pssm-ID: 239801  Cd Length: 207  Bit Score: 350.77  E-value: 7.74e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  255 RYVEVMVTADAKMV-HHHGQNLQHYVLTLMSIVAAIYKDSSIGNLINIVIVKLVVIHSEQEGPVISFNAATTLRNFCLWQ 333
Cdd:cd04273     1 RYVETLVVADSKMVeFHHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  334 QSQNVPDDAHPSHHDTAVLITREDICGAKEKCDTLGLAELGTLCDPSRSCSISEENGLSAAFTIAHELGHVFNVPHDDSF 413
Cdd:cd04273    81 KKLNPPNDSDPEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDG 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 259155417  414 K-CKEAGikHQYHVMAPTLNYHTSPWTWSACSQKHITEFLDTGHGECLL 461
Cdd:cd04273   161 NsCGPEG--KDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCLL 207
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 1709-1905 7.76e-105

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


:

Pssm-ID: 462559  Cd Length: 200  Bit Score: 333.43  E-value: 7.76e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  1709 TTCKELQVTNNVTKDGDYDLNVRGRILKIHCSGMQLENPREYLPLVKSE-DNFSEIYGLRLQNPYECPFNGSRRPDCACE 1787
Cdd:pfam08685    2 RSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPqENYSEVYGYRLKNPNECPFNGSRRDDCACR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  1788 NDYLP-AGYTVFSKVRVDLESMQIKTADLLFSQTLSGKAVPFATAGDCYSAARCPQGQFSINLAGTGMKISNTAKWLAQG 1866
Cdd:pfam08685   82 QDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVSQG 161

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 259155417  1867 RYASVIIHRSQDGTKVYGRCGGFCGKCIPHMATGLSIQV 1905
Cdd:pfam08685  162 NYAVSKIHRSQDGTKVRGRCGGYCGKCTPSPGTGLLLDV 200
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 41-186 1.47e-37

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


:

Pssm-ID: 460254  Cd Length: 128  Bit Score: 137.83  E-value: 1.47e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417    41 EVVTPTRVNEFgdvfpqnrhfsRKKRSSGVPEPPPFRTHYRISAYGQLFQLNLSADAAFLAAGYTEVHLGtpvpGPGGRS 120
Cdd:pfam01562    1 EVVIPVRLDPS-----------RRRRSLASESTYLDTLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTYYL----DGGTGV 65

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 259155417   121 TESPDLR-HCFYRGQVNAREDHTAVFSLCGGLMGTFKANDGEYFLEPVLRadgsAHDDDHNKPHLIY 186
Cdd:pfam01562   66 ESPPVQTdHCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEK----YSREEGGHPHVVY 128
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 719-836 3.58e-31

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 119.22  E-value: 3.58e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417   719 TLAGVFNSAH-YGYNVVVKIPAGATNIEILQHSYSGrpeddNYLALSDTQGNFLLNGNFVVSMAKKEINIQGAVFEYSGS 797
Cdd:pfam05986    1 TVSGSFTEGRaKGYVTFVTIPAGATHIHIVNRKPSF-----THLAVKNVQGKYILNGKGSISLNPTYPSLLGTVLEYRRS 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 259155417   798 NNSIERINSTDRLEAELVLQVLCV-GNLYNPDVRYSFNIP 836
Cdd:pfam05986   76 LPALEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 476-543 6.55e-19

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


:

Pssm-ID: 465496  Cd Length: 68  Bit Score: 82.39  E-value: 6.55e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417   476 PGSVYDGNRQCELMFGPGSQVCPYLKH--CRRLWCTsaEGVHKGCRTQHMPLADGTSCGPGMHCHRGLCV 543
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEdvCSKLWCS--NPGGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1076-1130 3.66e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 68.63  E-value: 3.66e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1076 WHVGPWGSCTATCGHGYQMRAVKCISEIFGTMLDDRECPQASRPSDRQDCILAPC 1130
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1304-1355 4.81e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 68.25  E-value: 4.81e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1304 WRTGPWGACSRSCAGGLQHRAVVCQDEDGRSATS---CDGSSKPPESRHCGSGPC 1355
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPdseCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1358-1410 1.53e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.01  E-value: 1.53e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1358 WNYGDWGECTQTCGGGVKSRFVICQFPNGQMTQEHS-CE-LPKPPSMMQCHLHAC 1410
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSeCSaQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 556-608 4.89e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 62.22  E-value: 4.89e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 259155417    556 WGPWGPYSSCSRTCGGGIKSTARLCDRPEPRNGGRYCVGRRMKFRSCNTDSCP 608
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1207-1259 6.61e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.09  E-value: 6.61e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1207 WQAGDWSPCSASCGHGKTTRRVLCVNYH--QLVDESYCDPEGRPVTEQECSLAAC 1259
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1416-1469 2.08e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.85  E-value: 2.08e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1416 WYRGPWKSCSASCGKGVKYREVLCIDQFQRKLE-EKYCSHLHKPRTHKACRSGRC 1469
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVpDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1021-1073 2.85e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.46  E-value: 2.85e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1021 WATSEWSECPVTCGKGMKQRQVWCQ--LSEDPMRDGFCNASTKPESLRPCELRAC 1073
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1472-1525 4.30e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.08  E-value: 4.30e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1472 WKANKWKECSVTCGSGVQQREVYCR-LRGTGRVSEDMCDPSTRPQGQRQCWRQDC 1525
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1152-1204 1.71e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.15  E-value: 1.71e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1152 WRHGSWTPCSVSCGRGSQARYVSCRDAHD-EVADESNCAHLPRPAAVSLCFS-PC 1204
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgSIVPDSECSAQKKPPETQSCNLkPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 613-717 2.59e-09

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 56.64  E-value: 2.59e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417   613 DFREKQCSDFDGKHFDIN-GLPPNVRW---LPKYSGIAVkdrCKLYCRVAGTTSFYQLKDRVADGTPCGTE------TND 682
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWgaaVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 259155417   683 ICVQGLCRQAGCDHVLNSKAKRDKCGVCGGDNSSC 717
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 966-1018 3.49e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.38  E-value: 3.49e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417   966 WHYSEWSQCSRSCGGGDKTRESYCVNGFGHRL-AESECRELPR-VVLENCNEFPC 1018
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQKKpPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1654-1705 6.52e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.91  E-value: 6.52e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1654 WKVGKWSKCSVTCGIGIMERRVACRTENG---WPSDLCLKRLKPDAQKKCYANDC 1705
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1530-1583 7.78e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.53  E-value: 7.78e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1530 WTTGDWLDCSTSCKKKETYRLVKCVNEQNVQAN-ESLCDPLTKPLSIKKCRNPHC 1583
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVpDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 846-897 1.72e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 46.68  E-value: 1.72e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 259155417   846 WDpYGPWQDCTKMC-QGLHRRKIACVRKSDHAVVSDHNCGHLPMPLfVTEKCN 897
Cdd:pfam19030    1 WV-AGPWGECSVTCgGGVQTRLVQCVQKGGGSIVPDSECSAQKKPP-ETQSCN 51
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 904-957 5.62e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 42.44  E-value: 5.62e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 259155417   904 WHIIGKSDCSSQCGQGYRTLDVHCmkysVHKGQAVPVGDQYCGDQLKPPSREPC 957
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQC----VQKGGGSIVPDSECSAQKKPPETQSC 50
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 255-461 7.74e-111

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 350.77  E-value: 7.74e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  255 RYVEVMVTADAKMV-HHHGQNLQHYVLTLMSIVAAIYKDSSIGNLINIVIVKLVVIHSEQEGPVISFNAATTLRNFCLWQ 333
Cdd:cd04273     1 RYVETLVVADSKMVeFHHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  334 QSQNVPDDAHPSHHDTAVLITREDICGAKEKCDTLGLAELGTLCDPSRSCSISEENGLSAAFTIAHELGHVFNVPHDDSF 413
Cdd:cd04273    81 KKLNPPNDSDPEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDG 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 259155417  414 K-CKEAGikHQYHVMAPTLNYHTSPWTWSACSQKHITEFLDTGHGECLL 461
Cdd:cd04273   161 NsCGPEG--KDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCLL 207
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 1709-1905 7.76e-105

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


Pssm-ID: 462559  Cd Length: 200  Bit Score: 333.43  E-value: 7.76e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  1709 TTCKELQVTNNVTKDGDYDLNVRGRILKIHCSGMQLENPREYLPLVKSE-DNFSEIYGLRLQNPYECPFNGSRRPDCACE 1787
Cdd:pfam08685    2 RSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPqENYSEVYGYRLKNPNECPFNGSRRDDCACR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  1788 NDYLP-AGYTVFSKVRVDLESMQIKTADLLFSQTLSGKAVPFATAGDCYSAARCPQGQFSINLAGTGMKISNTAKWLAQG 1866
Cdd:pfam08685   82 QDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVSQG 161

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 259155417  1867 RYASVIIHRSQDGTKVYGRCGGFCGKCIPHMATGLSIQV 1905
Cdd:pfam08685  162 NYAVSKIHRSQDGTKVRGRCGGYCGKCTPSPGTGLLLDV 200
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 41-186 1.47e-37

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 137.83  E-value: 1.47e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417    41 EVVTPTRVNEFgdvfpqnrhfsRKKRSSGVPEPPPFRTHYRISAYGQLFQLNLSADAAFLAAGYTEVHLGtpvpGPGGRS 120
Cdd:pfam01562    1 EVVIPVRLDPS-----------RRRRSLASESTYLDTLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTYYL----DGGTGV 65

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 259155417   121 TESPDLR-HCFYRGQVNAREDHTAVFSLCGGLMGTFKANDGEYFLEPVLRadgsAHDDDHNKPHLIY 186
Cdd:pfam01562   66 ESPPVQTdHCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEK----YSREEGGHPHVVY 128
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 719-836 3.58e-31

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 119.22  E-value: 3.58e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417   719 TLAGVFNSAH-YGYNVVVKIPAGATNIEILQHSYSGrpeddNYLALSDTQGNFLLNGNFVVSMAKKEINIQGAVFEYSGS 797
Cdd:pfam05986    1 TVSGSFTEGRaKGYVTFVTIPAGATHIHIVNRKPSF-----THLAVKNVQGKYILNGKGSISLNPTYPSLLGTVLEYRRS 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 259155417   798 NNSIERINSTDRLEAELVLQVLCV-GNLYNPDVRYSFNIP 836
Cdd:pfam05986   76 LPALEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 255-464 1.90e-30

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 120.10  E-value: 1.90e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417   255 RYVEVMVTADAKMVHHHGQNLQH---YVLTLMSIVAAIYKDssignlINIVIVkLVV--IHSEQEGPVISFNAATTLRNF 329
Cdd:pfam01421    1 KYIELFIVVDKQLFQKMGSDTTVvrqRVFQVVNLVNSIYKE------LNIRVV-LVGleIWTDEDKIDVSGDANDTLRNF 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417   330 CLWQQSQNVpddaHPSHHDTAVLITREDICGAkekcdTLGLAELGTLCDPSRSCSISE---ENGLSAAFTIAHELGHVFN 406
Cdd:pfam01421   74 LKWRQEYLK----KRKPHDVAQLLSGVEFGGT-----TVGAAYVGGMCSLEYSGGVNEdhsKNLESFAVTMAHELGHNLG 144

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 259155417   407 VPHDDSF---KCKEAGIkhqyHVMAPTLNyHTSPWTWSACSQKHITEFLDTGHGECLLDKP 464
Cdd:pfam01421  145 MQHDDFNggcKCPPGGG----CIMNPSAG-SSFPRKFSNCSQEDFEQFLTKQKGACLFNKP 200
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 476-543 6.55e-19

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 82.39  E-value: 6.55e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417   476 PGSVYDGNRQCELMFGPGSQVCPYLKH--CRRLWCTsaEGVHKGCRTQHMPLADGTSCGPGMHCHRGLCV 543
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEdvCSKLWCS--NPGGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1076-1130 3.66e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 68.63  E-value: 3.66e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1076 WHVGPWGSCTATCGHGYQMRAVKCISEIFGTMLDDRECPQASRPSDRQDCILAPC 1130
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1304-1355 4.81e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 68.25  E-value: 4.81e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1304 WRTGPWGACSRSCAGGLQHRAVVCQDEDGRSATS---CDGSSKPPESRHCGSGPC 1355
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPdseCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1358-1410 1.53e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.01  E-value: 1.53e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1358 WNYGDWGECTQTCGGGVKSRFVICQFPNGQMTQEHS-CE-LPKPPSMMQCHLHAC 1410
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSeCSaQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 556-608 4.89e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 62.22  E-value: 4.89e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 259155417    556 WGPWGPYSSCSRTCGGGIKSTARLCDRPEPRNGGRYCVGRRMKFRSCNTDSCP 608
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1207-1259 6.61e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.09  E-value: 6.61e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1207 WQAGDWSPCSASCGHGKTTRRVLCVNYH--QLVDESYCDPEGRPVTEQECSLAAC 1259
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1416-1469 2.08e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.85  E-value: 2.08e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1416 WYRGPWKSCSASCGKGVKYREVLCIDQFQRKLE-EKYCSHLHKPRTHKACRSGRC 1469
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVpDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1021-1073 2.85e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.46  E-value: 2.85e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1021 WATSEWSECPVTCGKGMKQRQVWCQ--LSEDPMRDGFCNASTKPESLRPCELRAC 1073
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1472-1525 4.30e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.08  E-value: 4.30e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1472 WKANKWKECSVTCGSGVQQREVYCR-LRGTGRVSEDMCDPSTRPQGQRQCWRQDC 1525
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1152-1204 1.71e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.15  E-value: 1.71e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1152 WRHGSWTPCSVSCGRGSQARYVSCRDAHD-EVADESNCAHLPRPAAVSLCFS-PC 1204
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgSIVPDSECSAQKKPPETQSCNLkPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 613-717 2.59e-09

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 56.64  E-value: 2.59e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417   613 DFREKQCSDFDGKHFDIN-GLPPNVRW---LPKYSGIAVkdrCKLYCRVAGTTSFYQLKDRVADGTPCGTE------TND 682
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWgaaVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 259155417   683 ICVQGLCRQAGCDHVLNSKAKRDKCGVCGGDNSSC 717
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 966-1018 3.49e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.38  E-value: 3.49e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417   966 WHYSEWSQCSRSCGGGDKTRESYCVNGFGHRL-AESECRELPR-VVLENCNEFPC 1018
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQKKpPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1204-1260 4.78e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 51.05  E-value: 4.78e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 259155417   1204 CGEWqaGDWSPCSASCGHGKTTRRVLCVNYHQLVDESYCDpeGRPVTEQECSLAACP 1260
Cdd:smart00209    1 WSEW--SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCT--GEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1654-1705 6.52e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.91  E-value: 6.52e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1654 WKVGKWSKCSVTCGIGIMERRVACRTENG---WPSDLCLKRLKPDAQKKCYANDC 1705
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1530-1583 7.78e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.53  E-value: 7.78e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1530 WTTGDWLDCSTSCKKKETYRLVKCVNEQNVQAN-ESLCDPLTKPLSIKKCRNPHC 1583
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVpDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 846-897 1.72e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 46.68  E-value: 1.72e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 259155417   846 WDpYGPWQDCTKMC-QGLHRRKIACVRKSDHAVVSDHNCGHLPMPLfVTEKCN 897
Cdd:pfam19030    1 WV-AGPWGECSVTCgGGVQTRLVQCVQKGGGSIVPDSECSAQKKPP-ETQSCN 51
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 557-607 5.84e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 44.96  E-value: 5.84e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 259155417   557 GPWGPYSSCSRTCGGGIKSTARLCDRPePRNGGRYCvGRRMKFRSCNTDSC 607
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1021-1073 7.17e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.89  E-value: 7.17e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 259155417   1021 WATSEWSECPVTCGKGMKQRQVWCQLSEDPMRDGFCNaSTKPESlRPCELRAC 1073
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCT-GEDVET-RACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 966-1019 1.53e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.11  E-value: 1.53e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 259155417    966 WHYSEWSQCSRSCGGGDKTRESYCVNgFGHRLAESECRELPRVVlENCNEFPCP 1019
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCS-PPPQNGGGPCTGEDVET-RACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 904-957 5.62e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 42.44  E-value: 5.62e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 259155417   904 WHIIGKSDCSSQCGQGYRTLDVHCmkysVHKGQAVPVGDQYCGDQLKPPSREPC 957
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQC----VQKGGGSIVPDSECSAQKKPPETQSC 50
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1304-1356 9.22e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.11  E-value: 9.22e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 259155417   1304 WRTGPWGACSRSCAGGLQHRAVVCQDEDGR-SATSCDGSSkpPESRHCGSGPCP 1356
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQnGGGPCTGED--VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1357-1411 1.54e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.34  E-value: 1.54e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417   1357 HWNYGDWGECTQTCGGGVKSRFVICQFPNGQMtQEHSCELPKpPSMMQCHLHACP 1411
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGED-VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1076-1130 1.57e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.34  E-value: 1.57e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417   1076 WHVGPWGSCTATCGHGYQMRAVKCISeiFGTMLDDRECPQASRpsDRQDCILAPC 1130
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCS--PPPQNGGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1419-1470 3.70e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 3.70e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 259155417   1419 GPWKSCSASCGKGVKYREVLCIDqFQRKLEEKYCSHLHkpRTHKACRSGRCP 1470
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCS-PPPQNGGGPCTGED--VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1155-1179 4.59e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 4.59e-03
                            10        20
                    ....*....|....*....|....*
gi 259155417   1155 GSWTPCSVSCGRGSQARYVSCRDAH 1179
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPP 29
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 255-461 7.74e-111

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 350.77  E-value: 7.74e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  255 RYVEVMVTADAKMV-HHHGQNLQHYVLTLMSIVAAIYKDSSIGNLINIVIVKLVVIHSEQEGPVISFNAATTLRNFCLWQ 333
Cdd:cd04273     1 RYVETLVVADSKMVeFHHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  334 QSQNVPDDAHPSHHDTAVLITREDICGAKEKCDTLGLAELGTLCDPSRSCSISEENGLSAAFTIAHELGHVFNVPHDDSF 413
Cdd:cd04273    81 KKLNPPNDSDPEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDG 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 259155417  414 K-CKEAGikHQYHVMAPTLNYHTSPWTWSACSQKHITEFLDTGHGECLL 461
Cdd:cd04273   161 NsCGPEG--KDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCLL 207
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 1709-1905 7.76e-105

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


Pssm-ID: 462559  Cd Length: 200  Bit Score: 333.43  E-value: 7.76e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  1709 TTCKELQVTNNVTKDGDYDLNVRGRILKIHCSGMQLENPREYLPLVKSE-DNFSEIYGLRLQNPYECPFNGSRRPDCACE 1787
Cdd:pfam08685    2 RSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPqENYSEVYGYRLKNPNECPFNGSRRDDCACR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  1788 NDYLP-AGYTVFSKVRVDLESMQIKTADLLFSQTLSGKAVPFATAGDCYSAARCPQGQFSINLAGTGMKISNTAKWLAQG 1866
Cdd:pfam08685   82 QDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVSQG 161

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 259155417  1867 RYASVIIHRSQDGTKVYGRCGGFCGKCIPHMATGLSIQV 1905
Cdd:pfam08685  162 NYAVSKIHRSQDGTKVRGRCGGYCGKCTPSPGTGLLLDV 200
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 255-453 1.06e-52

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 183.78  E-value: 1.06e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  255 RYVEVMVTADAKMV---HHHGQNLQHYVLTLMSIVAAIYKDSSIGNLINIVIVKLVVIHSEQEGPVISFNAATTLRNFCL 331
Cdd:cd04267     1 REIELVVVADHRMVsyfNSDENILQAYITELINIANSIYRSTNLRLGIRISLEGLQILKGEQFAPPIDSDASNTLNSFSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  332 WQQSQnvpddahPSHHDTAVLITREDicgaKEKCDTLGLAELGTLCDPSRSCSISEENG--LSAAFTIAHELGHVFNVPH 409
Cdd:cd04267    81 WRAEG-------PIRHDNAVLLTAQD----FIEGDILGLAYVGSMCNPYSSVGVVEDTGftLLTALTMAHELGHNLGAEH 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 259155417  410 DDSFKCKEAGIKHQYHVMAPTLNYhTSPWTWSACSQKHITEFLD 453
Cdd:cd04267   150 DGGDELAFECDGGGNYIMAPVDSG-LNSYRFSQCSIGSIREFLD 192
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 41-186 1.47e-37

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 137.83  E-value: 1.47e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417    41 EVVTPTRVNEFgdvfpqnrhfsRKKRSSGVPEPPPFRTHYRISAYGQLFQLNLSADAAFLAAGYTEVHLGtpvpGPGGRS 120
Cdd:pfam01562    1 EVVIPVRLDPS-----------RRRRSLASESTYLDTLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTYYL----DGGTGV 65

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 259155417   121 TESPDLR-HCFYRGQVNAREDHTAVFSLCGGLMGTFKANDGEYFLEPVLRadgsAHDDDHNKPHLIY 186
Cdd:pfam01562   66 ESPPVQTdHCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEK----YSREEGGHPHVVY 128
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 255-462 4.59e-33

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 127.35  E-value: 4.59e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  255 RYVEVMVTADAKMVHHHGQNL---QHYVLTLMSIVAAIYKDssignlINI-VIVKLVVIHSEQEGPVISFNAATTLRNFC 330
Cdd:cd04269     1 KYVELVVVVDNSLYKKYGSNLskvRQRVIEIVNIVDSIYRP------LNIrVVLVGLEIWTDKDKISVSGDAGETLNRFL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  331 LWQQSqnvpDDAHPSHHDTAVLITREDICGakekcDTLGLAELGTLCDPSRSCSISE---ENGLSAAFTIAHELGHVFNV 407
Cdd:cd04269    75 DWKRS----NLLPRKPHDNAQLLTGRDFDG-----NTVGLAYVGGMCSPKYSGGVVQdhsRNLLLFAVTMAHELGHNLGM 145

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 259155417  408 PHDDSF-KCKEAGIkhqyhVMAPTLNYHTspWTWSACSQKHITEFLDTGHGECLLD 462
Cdd:cd04269   146 EHDDGGcTCGRSTC-----IMAPSPSSLT--DAFSNCSYEDYQKFLSRGGGQCLLN 194
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 719-836 3.58e-31

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 119.22  E-value: 3.58e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417   719 TLAGVFNSAH-YGYNVVVKIPAGATNIEILQHSYSGrpeddNYLALSDTQGNFLLNGNFVVSMAKKEINIQGAVFEYSGS 797
Cdd:pfam05986    1 TVSGSFTEGRaKGYVTFVTIPAGATHIHIVNRKPSF-----THLAVKNVQGKYILNGKGSISLNPTYPSLLGTVLEYRRS 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 259155417   798 NNSIERINSTDRLEAELVLQVLCV-GNLYNPDVRYSFNIP 836
Cdd:pfam05986   76 LPALEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 255-464 1.90e-30

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 120.10  E-value: 1.90e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417   255 RYVEVMVTADAKMVHHHGQNLQH---YVLTLMSIVAAIYKDssignlINIVIVkLVV--IHSEQEGPVISFNAATTLRNF 329
Cdd:pfam01421    1 KYIELFIVVDKQLFQKMGSDTTVvrqRVFQVVNLVNSIYKE------LNIRVV-LVGleIWTDEDKIDVSGDANDTLRNF 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417   330 CLWQQSQNVpddaHPSHHDTAVLITREDICGAkekcdTLGLAELGTLCDPSRSCSISE---ENGLSAAFTIAHELGHVFN 406
Cdd:pfam01421   74 LKWRQEYLK----KRKPHDVAQLLSGVEFGGT-----TVGAAYVGGMCSLEYSGGVNEdhsKNLESFAVTMAHELGHNLG 144

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 259155417   407 VPHDDSF---KCKEAGIkhqyHVMAPTLNyHTSPWTWSACSQKHITEFLDTGHGECLLDKP 464
Cdd:pfam01421  145 MQHDDFNggcKCPPGGG----CIMNPSAG-SSFPRKFSNCSQEDFEQFLTKQKGACLFNKP 200
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 255-452 4.94e-20

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 89.12  E-value: 4.94e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  255 RYVEVMVTADAKMVHhhGQNLQHYVLTLMSIVAAIYKDSsigNLINIVIVKLVVIHseqegpvisfnaattlrnfclwqq 334
Cdd:cd00203     1 KVIPYVVVADDRDVE--EENLSAQIQSLILIAMQIWRDY---LNIRFVLVGVEIDK------------------------ 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  335 sqnvpddahpshHDTAVLITREDIcgakeKCDTLGLAELGTLCDPSRSCSISEENGL---SAAFTIAHELGHVFNVPHDD 411
Cdd:cd00203    52 ------------ADIAILVTRQDF-----DGGTGGWAYLGRVCDSLRGVGVLQDNQSgtkEGAQTIAHELGHALGFYHDH 114

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 259155417  412 SFKCKEAGIKH----------QYHVMAPTL--NYHTSPWTWSACSQKHITEFL 452
Cdd:cd00203   115 DRKDRDDYPTIddtlnaedddYYSVMSYTKgsFSDGQRKDFSQCDIDQINKLY 167
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 476-543 6.55e-19

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 82.39  E-value: 6.55e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417   476 PGSVYDGNRQCELMFGPGSQVCPYLKH--CRRLWCTsaEGVHKGCRTQHMPLADGTSCGPGMHCHRGLCV 543
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEdvCSKLWCS--NPGGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1076-1130 3.66e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 68.63  E-value: 3.66e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1076 WHVGPWGSCTATCGHGYQMRAVKCISEIFGTMLDDRECPQASRPSDRQDCILAPC 1130
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1304-1355 4.81e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 68.25  E-value: 4.81e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1304 WRTGPWGACSRSCAGGLQHRAVVCQDEDGRSATS---CDGSSKPPESRHCGSGPC 1355
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPdseCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1358-1410 1.53e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.01  E-value: 1.53e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1358 WNYGDWGECTQTCGGGVKSRFVICQFPNGQMTQEHS-CE-LPKPPSMMQCHLHAC 1410
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSeCSaQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 556-608 4.89e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 62.22  E-value: 4.89e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 259155417    556 WGPWGPYSSCSRTCGGGIKSTARLCDRPEPRNGGRYCVGRRMKFRSCNTDSCP 608
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1207-1259 6.61e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.09  E-value: 6.61e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1207 WQAGDWSPCSASCGHGKTTRRVLCVNYH--QLVDESYCDPEGRPVTEQECSLAAC 1259
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggSIVPDSECSAQKKPPETQSCNLKPC 55
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 256-460 1.28e-11

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 66.22  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  256 YVEVMVTADAKMVHHHGQNLQ--HYVLTLMSIVAAIYKDSSIGNlINIVIVKLVVIHSEQEGPVI------SFNAATTLR 327
Cdd:cd04272     2 YPELFVVVDYDHQSEFFSNEQliRYLAVMVNAANLRYRDLKSPR-IRLLLVGITISKDPDFEPYIhpinygYIDAAETLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417  328 NFclwqqSQNVPDDAHPSHHDTAVLITREDIC---GAKEKCDTLGLAELGTLCDpSRSCSISEENGLS--AAFTIAHELG 402
Cdd:cd04272    81 NF-----NEYVKKKRDYFNPDVVFLVTGLDMStysGGSLQTGTGGYAYVGGACT-ENRVAMGEDTPGSyyGVYTMTHELA 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 259155417  403 HVFNVPHD------------DSFKCK-EAGikhqyHVMApTLNYHTSPWTWSACSQKHITEFLDTGHGECL 460
Cdd:cd04272   155 HLLGAPHDgspppswvkghpGSLDCPwDDG-----YIMS-YVVNGERQYRFSQCSQRQIRNVFRRLGASCL 219
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1416-1469 2.08e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.85  E-value: 2.08e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1416 WYRGPWKSCSASCGKGVKYREVLCIDQFQRKLE-EKYCSHLHKPRTHKACRSGRC 1469
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVpDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1021-1073 2.85e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.46  E-value: 2.85e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1021 WATSEWSECPVTCGKGMKQRQVWCQ--LSEDPMRDGFCNASTKPESLRPCELRAC 1073
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1472-1525 4.30e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.08  E-value: 4.30e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1472 WKANKWKECSVTCGSGVQQREVYCR-LRGTGRVSEDMCDPSTRPQGQRQCWRQDC 1525
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1152-1204 1.71e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.15  E-value: 1.71e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1152 WRHGSWTPCSVSCGRGSQARYVSCRDAHD-EVADESNCAHLPRPAAVSLCFS-PC 1204
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgSIVPDSECSAQKKPPETQSCNLkPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 613-717 2.59e-09

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 56.64  E-value: 2.59e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417   613 DFREKQCSDFDGKHFDIN-GLPPNVRW---LPKYSGIAVkdrCKLYCRVAGTTSFYQLKDRVADGTPCGTE------TND 682
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWgaaVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 259155417   683 ICVQGLCRQAGCDHVLNSKAKRDKCGVCGGDNSSC 717
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 966-1018 3.49e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.38  E-value: 3.49e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417   966 WHYSEWSQCSRSCGGGDKTRESYCVNGFGHRL-AESECRELPR-VVLENCNEFPC 1018
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQKKpPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1204-1260 4.78e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 51.05  E-value: 4.78e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 259155417   1204 CGEWqaGDWSPCSASCGHGKTTRRVLCVNYHQLVDESYCDpeGRPVTEQECSLAACP 1260
Cdd:smart00209    1 WSEW--SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCT--GEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1654-1705 6.52e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.91  E-value: 6.52e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1654 WKVGKWSKCSVTCGIGIMERRVACRTENG---WPSDLCLKRLKPDAQKKCYANDC 1705
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1530-1583 7.78e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.53  E-value: 7.78e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417  1530 WTTGDWLDCSTSCKKKETYRLVKCVNEQNVQAN-ESLCDPLTKPLSIKKCRNPHC 1583
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVpDSECSAQKKPPETQSCNLKPC 55
Reprolysin_2 pfam13574
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 273-452 4.33e-07

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 372637  Cd Length: 193  Bit Score: 52.25  E-value: 4.33e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417   273 QNLQHYVLTLMSIVAAIYKDSSIGnlINIVIVK----LVVIHSEQEGPVISFNAATTLRN---FCLWQQSQNvpddahps 345
Cdd:pfam13574    1 GNVTENLVNVVNRVNQIYEPDDIN--INGGLVNpgeiPATTSASDSGNNYCNSPTTIVRRlnfLSQWRGEQD-------- 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417   346 hHDTAVLITREDICGAkekcdTLGLAELGTLCDPSRSCsISEENGLSAAFT-------------IAHELGHVFNVPHDD- 411
Cdd:pfam13574   71 -YCLAHLVTMGTFSGG-----ELGLAYVGQICQKGASS-PKTNTGLSTTTNygsfnyptqewdvVAHEVGHNFGATHDCd 143

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 259155417   412 --------------SFKCKEAGikhqYHVMAPT---LNYHTSPwtwsaCSQKHITEFL 452
Cdd:pfam13574  144 gsqyassgcernaaTSVCSANG----SFIMNPAsksNNDLFSP-----CSISLICDVL 192
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
253-410 1.45e-06

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 50.88  E-value: 1.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417   253 YPRYVEVMVTADAKMVHHHGQN-LQHYVLTLM-SIVAAIYKDSSIgnliNIVIVKLVVIHSE---QEGPVISFNAATTLR 327
Cdd:pfam13688    1 STRTVALLVAADCSYVAAFGGDaAQANIINMVnTASNVYERDFNI----SLGLVNLTISDSTcpyTPPACSTGDSSDRLS 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417   328 NFclwqQSQNVPDDAHpsHHDTAVLITREDicgakekCDTLGLAELGTLC--DPSRSCSISEENG------LSAAFTIAH 399
Cdd:pfam13688   77 EF----QDFSAWRGTQ--NDDLAYLFLMTN-------CSGGGLAWLGQLCnsGSAGSVSTRVSGNnvvvstATEWQVFAH 143

                          170
                   ....*....|.
gi 259155417   400 ELGHVFNVPHD 410
Cdd:pfam13688  144 EIGHNFGAVHD 154
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 846-897 1.72e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 46.68  E-value: 1.72e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 259155417   846 WDpYGPWQDCTKMC-QGLHRRKIACVRKSDHAVVSDHNCGHLPMPLfVTEKCN 897
Cdd:pfam19030    1 WV-AGPWGECSVTCgGGVQTRLVQCVQKGGGSIVPDSECSAQKKPP-ETQSCN 51
Reprolysin_3 pfam13582
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 278-410 3.58e-06

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 463926 [Multi-domain]  Cd Length: 122  Bit Score: 47.75  E-value: 3.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259155417   278 YVLTLMSIVAAIY-KDSSIG-NLINIVIVklvvihSEQEGPVISFNAATTLRNFCLWQQSQNVPDDAhpshhDTAVLITR 355
Cdd:pfam13582    2 RIVSLVNRANTIYeRDLGIRlQLAAIIIT------TSADTPYTSSDALEILDELQEVNDTRIGQYGY-----DLGHLFTG 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 259155417   356 EDICGakekcdTLGLAELGTLCDPSRSCSISE---ENGLSAAFTIAHELGHVFNVPHD 410
Cdd:pfam13582   71 RDGGG------GGGIAYVGGVCNSGSKFGVNSgsgPVGDTGADTFAHEIGHNFGLNHT 122
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 557-607 5.84e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 44.96  E-value: 5.84e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 259155417   557 GPWGPYSSCSRTCGGGIKSTARLCDRPePRNGGRYCvGRRMKFRSCNTDSC 607
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1021-1073 7.17e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.89  E-value: 7.17e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 259155417   1021 WATSEWSECPVTCGKGMKQRQVWCQLSEDPMRDGFCNaSTKPESlRPCELRAC 1073
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCT-GEDVET-RACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
557-607 1.31e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 43.95  E-value: 1.31e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 259155417   557 GPWGPYSSCSRTCGGGIKSTARLCDRPEPrnGGRYCVGRRMKFRSCNTDSC 607
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 966-1019 1.53e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.11  E-value: 1.53e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 259155417    966 WHYSEWSQCSRSCGGGDKTRESYCVNgFGHRLAESECRELPRVVlENCNEFPCP 1019
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCS-PPPQNGGGPCTGEDVET-RACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 904-957 5.62e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 42.44  E-value: 5.62e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 259155417   904 WHIIGKSDCSSQCGQGYRTLDVHCmkysVHKGQAVPVGDQYCGDQLKPPSREPC 957
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQC----VQKGGGSIVPDSECSAQKKPPETQSC 50
TSP_1 pfam00090
Thrombospondin type 1 domain;
1023-1073 1.72e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 40.86  E-value: 1.72e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 259155417  1023 TSEWSECPVTCGKGMKQRQVWCQlsEDPMRDGFCNASTkpESLRPCELRAC 1073
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTCK--SPFPGGEPCTGDD--IETQACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 961-985 6.73e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 39.18  E-value: 6.73e-04
                           10        20
                   ....*....|....*....|....*
gi 259155417   961 CVLTRWhySEWSQCSRSCGGGDKTR 985
Cdd:pfam19028    1 CVVSEW--SEWSECSVTCGGGVQTR 23
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1304-1356 9.22e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.11  E-value: 9.22e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 259155417   1304 WRTGPWGACSRSCAGGLQHRAVVCQDEDGR-SATSCDGSSkpPESRHCGSGPCP 1356
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQnGGGPCTGED--VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1357-1411 1.54e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.34  E-value: 1.54e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417   1357 HWNYGDWGECTQTCGGGVKSRFVICQFPNGQMtQEHSCELPKpPSMMQCHLHACP 1411
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGED-VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1076-1130 1.57e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.34  E-value: 1.57e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 259155417   1076 WHVGPWGSCTATCGHGYQMRAVKCISeiFGTMLDDRECPQASRpsDRQDCILAPC 1130
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCS--PPPQNGGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1419-1470 3.70e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 3.70e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 259155417   1419 GPWKSCSASCGKGVKYREVLCIDqFQRKLEEKYCSHLHkpRTHKACRSGRCP 1470
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCS-PPPQNGGGPCTGED--VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1155-1179 4.59e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 4.59e-03
                            10        20
                    ....*....|....*....|....*
gi 259155417   1155 GSWTPCSVSCGRGSQARYVSCRDAH 1179
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPP 29
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1024-1041 6.36e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 36.49  E-value: 6.36e-03
                           10
                   ....*....|....*...
gi 259155417  1024 SEWSECPVTCGKGMKQRQ 1041
Cdd:pfam19028    7 SEWSECSVTCGGGVQTRT 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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