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Conserved domains on  [gi|28976154|ref|NP_803235|]
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trafficking protein particle complex subunit 6B isoform 2 [Homo sapiens]

Protein Classification

trafficking protein particle complex subunit( domain architecture ID 10202223)

trafficking protein particle complex subunit is a component of TRAPP (transport protein particle) tethering complexes that have an important role at the different steps of vesicle transport

CATH:  3.30.1380.20
Gene Ontology:  GO:0006888|GO:0030008
PubMed:  9564032|27066478|18801063|22669257|20966969

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRAPPC6A_Trs33 cd14944
Trs33 subunit of the TRAPP complex; TRS33 (also known as TRAPPC6A) subunit of the trafficking ...
 3-128 2.32e-62

Trs33 subunit of the TRAPP complex; TRS33 (also known as TRAPPC6A) subunit of the trafficking protein particle complex (TRAPP). TRS33 is one of the six core subunits of TRAPP complexes which play a key role in the regulation of ER-to-Golgi and intra-Golgi transport by tethering the vesicle membrane to the target membrane. In mammals, mutations in TRAPPC6a cause mosaic loss of coat pigment.


:

Pssm-ID: 271347  Cd Length: 167  Bit Score: 187.85  E-value: 2.32e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28976154   3 DEALFLLLHNEMVSGVYKSAEQG----------EVENGRCITKLENMGFRVGQGLIERFTKDTARFKDELDIMKFICKDF 72
Cdd:cd14944   1 SESLFDFLLIEMVPYLLASASELkeseelddaeEEDDEAVLSRLEAIGFRVGLRLAERLTKDRPRFSDPLDVIKFICKDF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28976154  73 WTTVFKKQIDNLRTNHQ-------------------------------YLAFTCGLIRGGLSNLGIKSIVTAEVSSMPAC 121
Cdd:cd14944  81 WTAVFGKQIDNLRTNHRgvyvlqdnsfrwlsrlssgdgaaqsleeappYLAFPCGIIRGALANLGIPSTVTAEVTSLPGC 160


                ....*..
gi 28976154 122 KFQVMIQ 128
Cdd:cd14944 161 TFQIRIQ 167
 
Name Accession Description Interval E-value
TRAPPC6A_Trs33 cd14944
Trs33 subunit of the TRAPP complex; TRS33 (also known as TRAPPC6A) subunit of the trafficking ...
 3-128 2.32e-62

Trs33 subunit of the TRAPP complex; TRS33 (also known as TRAPPC6A) subunit of the trafficking protein particle complex (TRAPP). TRS33 is one of the six core subunits of TRAPP complexes which play a key role in the regulation of ER-to-Golgi and intra-Golgi transport by tethering the vesicle membrane to the target membrane. In mammals, mutations in TRAPPC6a cause mosaic loss of coat pigment.


Pssm-ID: 271347  Cd Length: 167  Bit Score: 187.85  E-value: 2.32e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28976154   3 DEALFLLLHNEMVSGVYKSAEQG----------EVENGRCITKLENMGFRVGQGLIERFTKDTARFKDELDIMKFICKDF 72
Cdd:cd14944   1 SESLFDFLLIEMVPYLLASASELkeseelddaeEEDDEAVLSRLEAIGFRVGLRLAERLTKDRPRFSDPLDVIKFICKDF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28976154  73 WTTVFKKQIDNLRTNHQ-------------------------------YLAFTCGLIRGGLSNLGIKSIVTAEVSSMPAC 121
Cdd:cd14944  81 WTAVFGKQIDNLRTNHRgvyvlqdnsfrwlsrlssgdgaaqsleeappYLAFPCGIIRGALANLGIPSTVTAEVTSLPGC 160


                ....*..
gi 28976154 122 KFQVMIQ 128
Cdd:cd14944 161 TFQIRIQ 167
TRAPP pfam04051
Transport protein particle (TRAPP) component; TRAPP plays a key role in the targeting and/or ...
 7-125 1.69e-41

Transport protein particle (TRAPP) component; TRAPP plays a key role in the targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment. TRAPP is a large multimeric protein that contains at least 10 subunits. This family contains many TRAPP family proteins. The Bet3 subunit is one of the better characterized TRAPP proteins and has a dimeric structure with hydrophobic channels. The channel entrances are located on a putative membrane-interacting surface that is distinctively flat, wide and decorated with positively charged residues. Bet3 is proposed to localize TRAPP to the Golgi.


Pssm-ID: 461147  Cd Length: 148  Bit Score: 134.53  E-value: 1.69e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28976154     7 FLLLHNEMVSGVYKSAEQGEvengRCITKLENMGFRVGQGLIE-RFTKD-TARFKDELDIMKFICKDFWTTVFKKQIDNL 84
Cdd:pfam04051   1 FALLYGELVAYLQKDSEDVE----EVNKRLEKMGYNIGQRLIElFLARDsRCRFTDFLETLKFICKDVWKMLFGKQADNL 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28976154    85 RTNHQ--------------------------YLAFTCGLIRGGLSNLGIKSIVTAevSSMPA------CKFQV 125
Cdd:pfam04051  77 ETNHDgeyvlidneppltrfvelpkdgsqlnYLAFLCGIIRGALEMLGFPARVTA--HFVPSdvlrgdTTFEI 147
COG5128 COG5128
Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];
7-119 1.30e-04

Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];


Pssm-ID: 227457  Cd Length: 208  Bit Score: 39.91  E-value: 1.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28976154   7 FLLLHNEMVSGVYKS-AEQGEVEngrciTKLENMGFRVGQGLIERFTKDTARFKDE---LDIMKFICKDFWTTVFKKQID 82
Cdd:COG5128  45 MAFLFCEMIEYLMEQrSGIQDFE-----AKLKSIGYEVGIKLLELCNFRRRNPKREvriLTILQRIHFDLWSYLFGDSDD 119

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28976154  83 NL----RTNHQYL------------------------AFTCGLIRGGLSNLGIKSIVTAEvsSMP 119
Cdd:COG5128 120 RLeksrEVDREYMivdndpllsrfisvpdewnglscdSIVCGIIQGFLMAAGFPCEVTAH--PEP 182
PTZ00391 PTZ00391
transport protein particle component (TRAPP) superfamily; Provisional
 7-86 2.53e-03

transport protein particle component (TRAPP) superfamily; Provisional


Pssm-ID: 240398  Cd Length: 168  Bit Score: 35.94  E-value: 2.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28976154    7 FLLLHNEMVSGVYKSAEQG-EVENgrcitKLENMGFRVGQGLIERFT---KDTARFKDELDIMKFICKDFWTTVFKKQID 82
Cdd:PTZ00391   6 FAFLFSEIVQYCLSKSKRGyRLED-----KLHEMGLRVGYKLNELLPyreKNQKRETKILSILTFISKHVWKYLFGHSSD 80


                 ....
gi 28976154   83 NLRT 86
Cdd:PTZ00391  81 LLKS 84
 
Name Accession Description Interval E-value
TRAPPC6A_Trs33 cd14944
Trs33 subunit of the TRAPP complex; TRS33 (also known as TRAPPC6A) subunit of the trafficking ...
 3-128 2.32e-62

Trs33 subunit of the TRAPP complex; TRS33 (also known as TRAPPC6A) subunit of the trafficking protein particle complex (TRAPP). TRS33 is one of the six core subunits of TRAPP complexes which play a key role in the regulation of ER-to-Golgi and intra-Golgi transport by tethering the vesicle membrane to the target membrane. In mammals, mutations in TRAPPC6a cause mosaic loss of coat pigment.


Pssm-ID: 271347  Cd Length: 167  Bit Score: 187.85  E-value: 2.32e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28976154   3 DEALFLLLHNEMVSGVYKSAEQG----------EVENGRCITKLENMGFRVGQGLIERFTKDTARFKDELDIMKFICKDF 72
Cdd:cd14944   1 SESLFDFLLIEMVPYLLASASELkeseelddaeEEDDEAVLSRLEAIGFRVGLRLAERLTKDRPRFSDPLDVIKFICKDF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28976154  73 WTTVFKKQIDNLRTNHQ-------------------------------YLAFTCGLIRGGLSNLGIKSIVTAEVSSMPAC 121
Cdd:cd14944  81 WTAVFGKQIDNLRTNHRgvyvlqdnsfrwlsrlssgdgaaqsleeappYLAFPCGIIRGALANLGIPSTVTAEVTSLPGC 160


                ....*..
gi 28976154 122 KFQVMIQ 128
Cdd:cd14944 161 TFQIRIQ 167
TRAPPC_bet3-like cd14941
Bet3-like domains of TRAPP; Bet3-like domains of a subfamily of core components of the ...
 3-126 6.48e-47

Bet3-like domains of TRAPP; Bet3-like domains of a subfamily of core components of the trafficking protein particle complex (TRAPP) include TRAPPC3, TRAPPC5, and TRAPPC6A. TRAPP complexes play a key role in the regulation of ER-to-Golgi and intra-Golgi transport by tethering the vesicle membrane to the target membrane. TRAPPs are large multimeric protein complexes which contain six core subunits that belong to two distinct structural families, the bet3-like family and the sedlin-like family.


Pssm-ID: 271344  Cd Length: 152  Bit Score: 148.38  E-value: 6.48e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28976154   3 DEALFLLLHNEMVSGVYKSAEqgevENGRCITKLENMGFRVGQGLIERFT--KDTARFKDELDIMKFICKDFWTTVFKKQ 80
Cdd:cd14941   1 SVSLFALLFGEMVSQLCKDYE----SVGDVNTKLADMGFNIGARLIEDFLarKNGKRCTKVLDILLFIKKNAWKALFGKT 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28976154  81 IDNLRTNHQ---------------------------YLAFTCGLIRGGLSNLGIKSIVTAEVSSM---PACKFQVM 126
Cdd:cd14941  77 PDILNWSHDddtyslidnepplndfislpdensslnYSAFTCGIIRGILENVGFPCKVTAHWDKLggdPGTEIMIK 152
TRAPP pfam04051
Transport protein particle (TRAPP) component; TRAPP plays a key role in the targeting and/or ...
 7-125 1.69e-41

Transport protein particle (TRAPP) component; TRAPP plays a key role in the targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment. TRAPP is a large multimeric protein that contains at least 10 subunits. This family contains many TRAPP family proteins. The Bet3 subunit is one of the better characterized TRAPP proteins and has a dimeric structure with hydrophobic channels. The channel entrances are located on a putative membrane-interacting surface that is distinctively flat, wide and decorated with positively charged residues. Bet3 is proposed to localize TRAPP to the Golgi.


Pssm-ID: 461147  Cd Length: 148  Bit Score: 134.53  E-value: 1.69e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28976154     7 FLLLHNEMVSGVYKSAEQGEvengRCITKLENMGFRVGQGLIE-RFTKD-TARFKDELDIMKFICKDFWTTVFKKQIDNL 84
Cdd:pfam04051   1 FALLYGELVAYLQKDSEDVE----EVNKRLEKMGYNIGQRLIElFLARDsRCRFTDFLETLKFICKDVWKMLFGKQADNL 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28976154    85 RTNHQ--------------------------YLAFTCGLIRGGLSNLGIKSIVTAevSSMPA------CKFQV 125
Cdd:pfam04051  77 ETNHDgeyvlidneppltrfvelpkdgsqlnYLAFLCGIIRGALEMLGFPARVTA--HFVPSdvlrgdTTFEI 147
TRAPPC5_Trs31 cd14943
Trs31 subunit of the TRAPP complex; TRS31 (also known as TRAPPC5) subunit of the trafficking ...
 5-113 1.18e-06

Trs31 subunit of the TRAPP complex; TRS31 (also known as TRAPPC5) subunit of the trafficking protein particle complex (TRAPP). TRS31 is one of the six core subunits of TRAPP complexes which play a key role in the regulation of ER-to-Golgi and intra-Golgi transport by tethering the vesicle membrane to the target membrane.


Pssm-ID: 271346  Cd Length: 158  Bit Score: 44.83  E-value: 1.18e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28976154   5 ALFLLLHNEMVSGVYKSAEQG-EVENgrcitKLENMGFRVGQGLIERFTKDTARFKDE---LDIMKFICKDFWTTVFKKQ 80
Cdd:cd14943   4 SAFAFLFSEMVQYAQRRVKSIsELEQ-----RLSELGYRVGIRLLELLSLREKGPKREtriLSILQFIKTTVWKYLFGKE 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28976154  81 IDNL----RTNHQYL------------------------AFTCGLIRGGLSNLGIKSIVTA 113
Cdd:cd14943  79 ADSLekstDDDNEYMiidneplvnkfisvpkdmgglncaAFVAGIIEGVLDSAGFPAKVTA 139
COG5128 COG5128
Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];
7-119 1.30e-04

Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];


Pssm-ID: 227457  Cd Length: 208  Bit Score: 39.91  E-value: 1.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28976154   7 FLLLHNEMVSGVYKS-AEQGEVEngrciTKLENMGFRVGQGLIERFTKDTARFKDE---LDIMKFICKDFWTTVFKKQID 82
Cdd:COG5128  45 MAFLFCEMIEYLMEQrSGIQDFE-----AKLKSIGYEVGIKLLELCNFRRRNPKREvriLTILQRIHFDLWSYLFGDSDD 119

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28976154  83 NL----RTNHQYL------------------------AFTCGLIRGGLSNLGIKSIVTAEvsSMP 119
Cdd:COG5128 120 RLeksrEVDREYMivdndpllsrfisvpdewnglscdSIVCGIIQGFLMAAGFPCEVTAH--PEP 182
PTZ00391 PTZ00391
transport protein particle component (TRAPP) superfamily; Provisional
 7-86 2.53e-03

transport protein particle component (TRAPP) superfamily; Provisional


Pssm-ID: 240398  Cd Length: 168  Bit Score: 35.94  E-value: 2.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28976154    7 FLLLHNEMVSGVYKSAEQG-EVENgrcitKLENMGFRVGQGLIERFT---KDTARFKDELDIMKFICKDFWTTVFKKQID 82
Cdd:PTZ00391   6 FAFLFSEIVQYCLSKSKRGyRLED-----KLHEMGLRVGYKLNELLPyreKNQKRETKILSILTFISKHVWKYLFGHSSD 80


                 ....
gi 28976154   83 NLRT 86
Cdd:PTZ00391  81 LLKS 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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