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Conserved domains on  [gi|29566861|ref|NP_818426|]
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DNA methyltransferase [Mycobacterium phage Omega]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 124-175 2.22e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member TIGR00675:

Pssm-ID: 473071 [Multi-domain]  Cd Length: 315  Bit Score: 72.36  E-value: 2.22e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 29566861   124 DQYGVRRLTPLECERLQGYPDGYTDRQSDAQRYRQLGNSVAIPCVQWIVNRL 175
Cdd:TIGR00675 264 HPGRIRRLTPRECARLQGFPDDFKFPVSDSQLYKQAGNAVVVPVIEAIAKQI 315
 
Name Accession Description Interval E-value
dcm TIGR00675
DNA-methyltransferase (dcm); All proteins in this family for which functions are known are ...
 124-175 2.22e-15

DNA-methyltransferase (dcm); All proteins in this family for which functions are known are DNA-cytosine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273211 [Multi-domain]  Cd Length: 315  Bit Score: 72.36  E-value: 2.22e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 29566861   124 DQYGVRRLTPLECERLQGYPDGYTDRQSDAQRYRQLGNSVAIPCVQWIVNRL 175
Cdd:TIGR00675 264 HPGRIRRLTPRECARLQGFPDDFKFPVSDSQLYKQAGNAVVVPVIEAIAKQI 315
Dcm COG0270
DNA-cytosine methylase [Replication, recombination and repair];
108-178 7.34e-14

DNA-cytosine methylase [Replication, recombination and repair];


Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 67.53  E-value: 7.34e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 29566861 108 LSTGGGKPGQgyaaIMDQYGVRRLTPLECERLQGYPDGYTDRQSDAQRYRQLGNSVAIPCVQWIVNRLVAF 178
Cdd:COG0270 207 ITAGYGGGGR----FLHPGEPRRLTVREAARLQGFPDDFKFPGSKTQAYRQIGNAVPPPLAEAIAKAILKA 273
Cyt_C5_DNA_methylase cd00315
Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many ...
 110-176 1.94e-12

Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.


Pssm-ID: 238192 [Multi-domain]  Cd Length: 275  Bit Score: 63.79  E-value: 1.94e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29566861 110 TGGGKPGQG------YAAIMDQYGVRRLTPLECERLQGYPDGY-TDRQSDAQRYRQLGNSVAIPCVQWIVNRLV 176
Cdd:cd00315 201 TASYGKGTGsvhptaPDMIGKESNIRRLTPRECARLQGFPDDFeFPGKSVTQAYRQIGNSVPVPVAEAIAKAIK 274
DNA_methylase pfam00145
C-5 cytosine-specific DNA methylase;
117-176 8.76e-12

C-5 cytosine-specific DNA methylase;


Pssm-ID: 395093 [Multi-domain]  Cd Length: 324  Bit Score: 62.33  E-value: 8.76e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29566861   117 QGYAAIMDQYGVRRLTPLECERLQGYPDGYTDRQSDAQRYRQLGNSVAIPCVQWIVNRLV 176
Cdd:pfam00145 264 NGERFRGHPKNIRRLTPRECARLQGFPDDFIFPGSKTQLYKQIGNAVPVPVAEAIAKAIK 323
PRK10458 PRK10458
DNA cytosine methylase; Provisional
 129-166 5.16e-10

DNA cytosine methylase; Provisional


Pssm-ID: 236696 [Multi-domain]  Cd Length: 467  Bit Score: 57.38  E-value: 5.16e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 29566861  129 RRLTPLECERLQGY--PDGYTDR--QSDAQRYRQLGNSVAIP 166
Cdd:PRK10458 402 RRLTPRECARLMGFeaPGEAKFRipVSDTQAYRQFGNSVVVP 443
 
Name Accession Description Interval E-value
dcm TIGR00675
DNA-methyltransferase (dcm); All proteins in this family for which functions are known are ...
 124-175 2.22e-15

DNA-methyltransferase (dcm); All proteins in this family for which functions are known are DNA-cytosine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273211 [Multi-domain]  Cd Length: 315  Bit Score: 72.36  E-value: 2.22e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 29566861   124 DQYGVRRLTPLECERLQGYPDGYTDRQSDAQRYRQLGNSVAIPCVQWIVNRL 175
Cdd:TIGR00675 264 HPGRIRRLTPRECARLQGFPDDFKFPVSDSQLYKQAGNAVVVPVIEAIAKQI 315
Dcm COG0270
DNA-cytosine methylase [Replication, recombination and repair];
108-178 7.34e-14

DNA-cytosine methylase [Replication, recombination and repair];


Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 67.53  E-value: 7.34e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 29566861 108 LSTGGGKPGQgyaaIMDQYGVRRLTPLECERLQGYPDGYTDRQSDAQRYRQLGNSVAIPCVQWIVNRLVAF 178
Cdd:COG0270 207 ITAGYGGGGR----FLHPGEPRRLTVREAARLQGFPDDFKFPGSKTQAYRQIGNAVPPPLAEAIAKAILKA 273
Cyt_C5_DNA_methylase cd00315
Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many ...
 110-176 1.94e-12

Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.


Pssm-ID: 238192 [Multi-domain]  Cd Length: 275  Bit Score: 63.79  E-value: 1.94e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29566861 110 TGGGKPGQG------YAAIMDQYGVRRLTPLECERLQGYPDGY-TDRQSDAQRYRQLGNSVAIPCVQWIVNRLV 176
Cdd:cd00315 201 TASYGKGTGsvhptaPDMIGKESNIRRLTPRECARLQGFPDDFeFPGKSVTQAYRQIGNSVPVPVAEAIAKAIK 274
DNA_methylase pfam00145
C-5 cytosine-specific DNA methylase;
117-176 8.76e-12

C-5 cytosine-specific DNA methylase;


Pssm-ID: 395093 [Multi-domain]  Cd Length: 324  Bit Score: 62.33  E-value: 8.76e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29566861   117 QGYAAIMDQYGVRRLTPLECERLQGYPDGYTDRQSDAQRYRQLGNSVAIPCVQWIVNRLV 176
Cdd:pfam00145 264 NGERFRGHPKNIRRLTPRECARLQGFPDDFIFPGSKTQLYKQIGNAVPVPVAEAIAKAIK 323
PRK10458 PRK10458
DNA cytosine methylase; Provisional
 129-166 5.16e-10

DNA cytosine methylase; Provisional


Pssm-ID: 236696 [Multi-domain]  Cd Length: 467  Bit Score: 57.38  E-value: 5.16e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 29566861  129 RRLTPLECERLQGY--PDGYTDR--QSDAQRYRQLGNSVAIP 166
Cdd:PRK10458 402 RRLTPRECARLMGFeaPGEAKFRipVSDTQAYRQFGNSVVVP 443
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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