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Conserved domains on  [gi|109809759|ref|NP_821079|]
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leucine-rich repeat transmembrane neuronal protein 3 precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-339 4.24e-28

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 116.96  E-value: 4.24e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  59 ISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNhisnideNAFNGIRRLKELILSSNRISYfLNNTFRPVTNLRNL 138
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTD-LPEELANLTNLKEL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 139 DLSYNQLHSLGSEqFRGLRKLLSLHLRSNSLRTIPvRIFQDCRNLELLDLGYNRIRSLArNVFAGMIRLKELHLEHNQFS 218
Cdd:COG4886  142 DLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLT 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 219 KLNLALfPRLVSLQNLYLQWNKISVIGQTMSWTwsSLQRLDLSGNEIEAFSGPSvfqCVPNLQRLNLDSNKLTFIGQEIL 298
Cdd:COG4886  219 DLPEPL-ANLTNLETLDLSNNQLTDLPELGNLT--NLEELDLSNNQLTDLPPLA---NLTNLKTLDLSNNQLTDLKLKEL 292

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 109809759 299 DSWISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTII 339
Cdd:COG4886  293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-61 4.66e-05

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.76  E-value: 4.66e-05
                           10        20
                   ....*....|....*....|....*....
gi 109809759    33 GCPKGCRCEGKMVYCESQKLQEIPSSISA 61
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPP 29
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-339 4.24e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 116.96  E-value: 4.24e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  59 ISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNhisnideNAFNGIRRLKELILSSNRISYfLNNTFRPVTNLRNL 138
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTD-LPEELANLTNLKEL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 139 DLSYNQLHSLGSEqFRGLRKLLSLHLRSNSLRTIPvRIFQDCRNLELLDLGYNRIRSLArNVFAGMIRLKELHLEHNQFS 218
Cdd:COG4886  142 DLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLT 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 219 KLNLALfPRLVSLQNLYLQWNKISVIGQTMSWTwsSLQRLDLSGNEIEAFSGPSvfqCVPNLQRLNLDSNKLTFIGQEIL 298
Cdd:COG4886  219 DLPEPL-ANLTNLETLDLSNNQLTDLPELGNLT--NLEELDLSNNQLTDLPPLA---NLTNLKTLDLSNNQLTDLKLKEL 292

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 109809759 299 DSWISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTII 339
Cdd:COG4886  293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 156-342 6.90e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 74.05  E-value: 6.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 156 LRKLLSLHLRSNSLRTIPvrIFQDCRNLELLDLGYNRIRSLARnvFAGMIRLKELHLEHNQFSKL-NLAlfpRLVSLQNL 234
Cdd:cd21340    1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIeNLE---NLVNLKKL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 235 YLQWNKISVI---------------------GQTMSWTW-------SSLQRLDLSGNEIEAfsgPSVFQCVPNLQRLNLD 286
Cdd:cd21340   74 YLGGNRISVVeglenltnleelhienqrlppGEKLTFDPrslaalsNSLRVLNISGNNIDS---LEPLAPLRNLEQLDAS 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 109809759 287 SNKLTFIGQ--EILDSWISLNDISLAGNIwecsrnICSLVNWlksfkglRENTIICAS 342
Cdd:cd21340  151 NNQISDLEEllDLLSSWPSLRELDLTGNP------VCKKPKY-------RDKIILASK 195
LRR_8 pfam13855
Leucine rich repeat;
133-193 1.74e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 1.74e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 109809759  133 TNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRI 193
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 54-218 5.36e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 5.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  54 EIPSSISAgCLGLS---LRYNSLQKLKYNQFKGLNQLTWLYLDHNHIS-NIDENAFNgIRRLKELILSSNRISYFLNNTF 129
Cdd:PLN00113 395 EIPKSLGA-CRSLRrvrLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD-MPSLQMLSLARNKFFGGLPDSF 472

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 130 RPvTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKE 209
Cdd:PLN00113 473 GS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQ 551


                 ....*....
gi 109809759 210 LHLEHNQFS 218
Cdd:PLN00113 552 LDLSQNQLS 560
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-61 4.66e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.76  E-value: 4.66e-05
                           10        20
                   ....*....|....*....|....*....
gi 109809759    33 GCPKGCRCEGKMVYCESQKLQEIPSSISA 61
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPP 29
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-60 1.53e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.07  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....*...
gi 109809759   33 GCPKGCRCEGKMVYCESQKLQEIPSSIS 60
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-339 4.24e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 116.96  E-value: 4.24e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  59 ISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNhisnideNAFNGIRRLKELILSSNRISYfLNNTFRPVTNLRNL 138
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTD-LPEELANLTNLKEL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 139 DLSYNQLHSLGSEqFRGLRKLLSLHLRSNSLRTIPvRIFQDCRNLELLDLGYNRIRSLArNVFAGMIRLKELHLEHNQFS 218
Cdd:COG4886  142 DLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLT 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 219 KLNLALfPRLVSLQNLYLQWNKISVIGQTMSWTwsSLQRLDLSGNEIEAFSGPSvfqCVPNLQRLNLDSNKLTFIGQEIL 298
Cdd:COG4886  219 DLPEPL-ANLTNLETLDLSNNQLTDLPELGNLT--NLEELDLSNNQLTDLPPLA---NLTNLKTLDLSNNQLTDLKLKEL 292

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 109809759 299 DSWISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTII 339
Cdd:COG4886  293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-312 1.76e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.25  E-value: 1.76e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  50 QKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELIlssnRISYFLNNTF 129
Cdd:COG4886   34 LLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT----ELDLSGNEEL 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 130 RPVTNLRNLDLSYNQLHSLGSEqFRGLRKLLSLHLRSNSLRTIPVRIFQdCRNLELLDLGYNRIRSLArNVFAGMIRLKE 209
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDLP-EELGNLTNLKE 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 210 LHLEHNQFSKLNLALFpRLVSLQNLYLQWNKISVIGQTMSwTWSSLQRLDLSGNEIEAFsgPSVFQCvPNLQRLNLDSNK 289
Cdd:COG4886  187 LDLSNNQITDLPEPLG-NLTNLEELDLSGNQLTDLPEPLA-NLTNLETLDLSNNQLTDL--PELGNL-TNLEELDLSNNQ 261

                        250       260
                 ....*....|....*....|...
gi 109809759 290 LTFIGQEIldSWISLNDISLAGN 312
Cdd:COG4886  262 LTDLPPLA--NLTNLKTLDLSNN 282
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-312 6.40e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.25  E-value: 6.40e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  66 LSLRYNSLQKLKyNQFKGLNQLTWLYLDHNHISNIDEnAFNGIRRLKELILSSNRISYfLNNTFRPVTNLRNLDLSYNQL 145
Cdd:COG4886  118 LDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQI 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 146 HSLgSEQFRGLRKLLSLHLRSNSLRTIPVRIFQdCRNLELLDLGYNRIRSLArnVFAGMIRLKELHLEHNQFSKLNLALf 225
Cdd:COG4886  195 TDL-PEPLGNLTNLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA- 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 226 pRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLN 305
Cdd:COG4886  270 -NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLA 348


                 ....*..
gi 109809759 306 DISLAGN 312
Cdd:COG4886  349 LLTLLLL 355
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-310 1.94e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.09  E-value: 1.94e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  43 KMVYCESQKLQEIPSSISA--GCLGLSLRYNSLQKLKyNQFKGLNQLTWLYLDHNHISNIDEnAFNGIRRLKELILSSNR 120
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 121 ISyFLNNTFRPVTNLRNLDLSYNQLHSLgSEQFRGLRKLLSLHLRSNSLRTIPVriFQDCRNLELLDLGYNRIRSLarNV 200
Cdd:COG4886  194 IT-DLPEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDL--PP 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 201 FAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNL 280
Cdd:COG4886  268 LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347

                        250       260       270
                 ....*....|....*....|....*....|
gi 109809759 281 QRLNLDSNKLTFIGQEILDSWISLNDISLA 310
Cdd:COG4886  348 ALLTLLLLLNLLSLLLTLLLTLGLLGLLEA 377
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-309 3.36e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 3.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  43 KMVYCESQKLQEIPSSISaGCLGL---SLRYNSLQKLKyNQFKGLNQLTWLYLDHNHISNIDEnAFNGIRRLKELILSSN 119
Cdd:COG4886  139 KELDLSNNQLTDLPEPLG-NLTNLkslDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 120 RISYfLNNTFRPVTNLRNLDLSYNQLHSLgsEQFRGLRKLLSLHLRSNSLRTIPVriFQDCRNLELLDLGYNRIRSLARN 199
Cdd:COG4886  216 QLTD-LPEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLK 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 200 VFAG------MIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSV 273
Cdd:COG4886  291 ELELllglnsLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLG 370

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 109809759 274 FQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISL 309
Cdd:COG4886  371 LLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLA 406
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 156-342 6.90e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 74.05  E-value: 6.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 156 LRKLLSLHLRSNSLRTIPvrIFQDCRNLELLDLGYNRIRSLARnvFAGMIRLKELHLEHNQFSKL-NLAlfpRLVSLQNL 234
Cdd:cd21340    1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIeNLE---NLVNLKKL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 235 YLQWNKISVI---------------------GQTMSWTW-------SSLQRLDLSGNEIEAfsgPSVFQCVPNLQRLNLD 286
Cdd:cd21340   74 YLGGNRISVVeglenltnleelhienqrlppGEKLTFDPrslaalsNSLRVLNISGNNIDS---LEPLAPLRNLEQLDAS 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 109809759 287 SNKLTFIGQ--EILDSWISLNDISLAGNIwecsrnICSLVNWlksfkglRENTIICAS 342
Cdd:cd21340  151 NNQISDLEEllDLLSSWPSLRELDLTGNP------VCKKPKY-------RDKIILASK 195
LRR_8 pfam13855
Leucine rich repeat;
133-193 1.74e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 1.74e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 109809759  133 TNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRI 193
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
157-217 8.81e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 8.81e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 109809759  157 RKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQF 217
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-145 1.41e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 1.41e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759   86 QLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQL 145
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-265 3.01e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 3.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  45 VYCESQKLQEIPSSISagCLGLSLRY---NSLQKLKynQFKGLNQLTWLYLDHNHISNIdENaFNGIRRLKELILSSNRI 121
Cdd:cd21340    7 LYLNDKNITKIDNLSL--CKNLKVLYlydNKITKIE--NLEFLTNLTHLYLQNNQIEKI-EN-LENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 122 SYF--LNNtfrpVTNLRNLDLSYNQlhsLGSEQfrglrkllSLHLRSNSLRTIpvrifqdCRNLELLDLGYNRIRSLarN 199
Cdd:cd21340   81 SVVegLEN----LTNLEELHIENQR---LPPGE--------KLTFDPRSLAAL-------SNSLRVLNISGNNIDSL--E 136

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 109809759 200 VFAGMIRLKELHLEHNQFSklnlalfprlvslqnlylqwnKISVIGQTMSwTWSSLQRLDLSGNEI 265
Cdd:cd21340  137 PLAPLRNLEQLDASNNQIS---------------------DLEELLDLLS-SWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
181-241 1.12e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.12e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 109809759  181 RNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKI 241
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
66-121 1.28e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 1.28e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 109809759   66 LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRI 121
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 54-218 5.36e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 5.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  54 EIPSSISAgCLGLS---LRYNSLQKLKYNQFKGLNQLTWLYLDHNHIS-NIDENAFNgIRRLKELILSSNRISYFLNNTF 129
Cdd:PLN00113 395 EIPKSLGA-CRSLRrvrLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD-MPSLQMLSLARNKFFGGLPDSF 472

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 130 RPvTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKE 209
Cdd:PLN00113 473 GS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQ 551


                 ....*....
gi 109809759 210 LHLEHNQFS 218
Cdd:PLN00113 552 LDLSQNQLS 560
LRR_8 pfam13855
Leucine rich repeat;
109-169 1.78e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.78e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 109809759  109 RRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSL 169
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
230-290 2.25e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 2.25e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 109809759  230 SLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSgPSVFQCVPNLQRLNLDSNKL 290
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 81-300 2.65e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.82  E-value: 2.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  81 FKGLNQLTWLYLDHNHISNIDENAFNGIRR---LKELILSSNRISY----FLNNTFRPVT-NLRNLDLSYNQLHSLGSEQ 152
Cdd:cd00116   77 LTKGCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLGDrglrLLAKGLKDLPpALEKLVLGRNRLEGASCEA 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 153 ----FRGLRKLLSLHLRSNSLRT--IPV--RIFQDCRNLELLDLGYNRIRSlarnvfAGMIRLKELhlehnqfsklnlal 224
Cdd:cd00116  157 lakaLRANRDLKELNLANNGIGDagIRAlaEGLKANCNLEVLDLNNNGLTD------EGASALAET-------------- 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 225 FPRLVSLQNLYLQWNKISVIG-----QTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPN---LQRLNLDSNKLTFIGQE 296
Cdd:cd00116  217 LASLKSLEVLNLGDNNLTDAGaaalaSALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEkesLLELDLRGNKFGEEGAQ 296


                 ....
gi 109809759 297 ILDS 300
Cdd:cd00116  297 LLAE 300
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 84-291 4.28e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.39  E-value: 4.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  84 LNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLH 163
Cdd:PLN00113 307 LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLI 386

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 164 LRSNSLRTIPVRIFQDCRNLE------------------------LLDLGYNRIR----------------SLARNVFAG 203
Cdd:PLN00113 387 LFSNSLEGEIPKSLGACRSLRrvrlqdnsfsgelpseftklplvyFLDISNNNLQgrinsrkwdmpslqmlSLARNKFFG 466

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 204 MI-------RLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKIS-VIGQTMSwTWSSLQRLDLSGNEieaFSG--PSV 273
Cdd:PLN00113 467 GLpdsfgskRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELS-SCKKLVSLDLSHNQ---LSGqiPAS 542

                        250
                 ....*....|....*...
gi 109809759 274 FQCVPNLQRLNLDSNKLT 291
Cdd:PLN00113 543 FSEMPVLSQLDLSQNQLS 560
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
86-332 8.42e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.01  E-value: 8.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  86 QLTWLYLDHNHISNIDENAFNGIrrlKELILSSNRIsyflnnTFRPVT---NLRNLDLSYNQLHSLGSEQFRGLRKLLSL 162
Cdd:PRK15370 200 QITTLILDNNELKSLPENLQGNI---KTLYANSNQL------TSIPATlpdTIQEMELSINRITELPERLPSALQSLDLF 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 163 HlrsNSLRTIPVRIFQDCRNLELLDlgyNRIRSLARNVFAGMIrlkELHLEHNQFSKLNLALFPrlvSLQNLYLQWNKIS 242
Cdd:PRK15370 271 H---NKISCLPENLPEELRYLSVYD---NSIRTLPAHLPSGIT---HLNVQSNSLTALPETLPP---GLKTLEAGENALT 338

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 243 VIGQTMSwtwSSLQRLDLSGNEIEAFsgPSVFQcvPNLQRLNLDSNKLTFIGQeildswislnDISLAGNIWECSRN-IC 321
Cdd:PRK15370 339 SLPASLP---PELQVLDVSKNQITVL--PETLP--PTITTLDVSRNALTNLPE----------NLPAALQIMQASRNnLV 401

                        250
                 ....*....|.
gi 109809759 322 SLVNWLKSFKG 332
Cdd:PRK15370 402 RLPESLPHFRG 412
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 99-291 1.10e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  99 NIDENAFNG------IRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLR-T 171
Cdd:PLN00113 124 NLSNNNFTGsiprgsIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgQ 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 172 IPVRIFQdCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWT 251
Cdd:PLN00113 204 IPRELGQ-MKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFS 282

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 109809759 252 WSSLQRLDLSGNeieAFSG--PSVFQCVPNLQRLNLDSNKLT 291
Cdd:PLN00113 283 LQKLISLDLSDN---SLSGeiPELVIQLQNLEILHLFSNNFT 321
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 111-317 1.65e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 1.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 111 LKELILSSN---RISYFLN---NTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSL---HLRSNSLRTIPVRI----F 177
Cdd:cd00116   53 LKELCLSLNetgRIPRGLQsllQGLTKGCGLQELDLSDNALGPDGCGVLESLLRSSSLqelKLNNNGLGDRGLRLlakgL 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 178 QDCR-NLELLDLGYNRI-----RSLArNVFAGMIRLKELHLEHNQfskLNLALFPRLVSlqnlylqwnkisviGQTMSwt 251
Cdd:cd00116  133 KDLPpALEKLVLGRNRLegascEALA-KALRANRDLKELNLANNG---IGDAGIRALAE--------------GLKAN-- 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 109809759 252 wSSLQRLDLSGNEIE-----AFSGpsVFQCVPNLQRLNLDSNKLTFIG-QEILDSWISLNDISLAGNIWECS 317
Cdd:cd00116  193 -CNLEVLDLNNNGLTdegasALAE--TLASLKSLEVLNLGDNNLTDAGaAALASALLSPNISLLTLSLSCND 261
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 116-315 4.51e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 4.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 116 LSSNRISYFL-NNTFRPVTNLRNLDLSYNQLHslGSEQFRGLRKLLSLHLRSNSLRTipvRIFQDC---RNLELLDLGYN 191
Cdd:PLN00113 100 LSNNQLSGPIpDDIFTTSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSNNMLSG---EIPNDIgsfSSLKVLDLGGN 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 192 RIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKIS-----VIGQTmswtwSSLQRLDLSGNEIE 266
Cdd:PLN00113 175 VLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgeipyEIGGL-----TSLNHLDLVYNNLT 249

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 109809759 267 AfSGPSVFQCVPNLQRLNLDSNKLTF-IGQEI--LDSWISLN--DISLAGNIWE 315
Cdd:PLN00113 250 G-PIPSSLGNLKNLQYLFLYQNKLSGpIPPSIfsLQKLISLDlsDNSLSGEIPE 302
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 82-291 1.49e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.48  E-value: 1.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  82 KGLNQLTWLYLDHNHIS-----NIDENAFNGiRRLKELILSSNRISY----FLNNTFRPVTNLRNLDLSYNQlhsLGSEQ 152
Cdd:COG5238  233 KGNKSLTTLDLSNNQIGdegviALAEALKNN-TTVETLYLSGNQIGAegaiALAKALQGNTTLTSLDLSVNR---IGDEG 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 153 FRGLRKllslHLRSNSlrtipvrifqdcrNLELLDLGYNRIRSlarnvfAGMIRLKElHLEHNQfsklnlalfprlvSLQ 232
Cdd:COG5238  309 AIALAE----GLQGNK-------------TLHTLNLAYNGIGA------QGAIALAK-ALQENT-------------TLH 351

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 109809759 233 NLYLQWNKISVIGQ----TMSWTWSSLQRLDLSGNEIEAFSGPSVFQC--VPNLQRLNLDSNKLT 291
Cdd:COG5238  352 SLDLSDNQIGDEGAialaKYLEGNTTLRELNLGKNNIGKQGAEALIDAlqTNRLHTLILDGNLIG 416
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 68-312 2.46e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 2.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  68 LRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHS 147
Cdd:PLN00113 219 LGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSG 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 148 LGSEQFRGLRKLLSLHLRSNSLR-TIPVRIFQDCR-----------------------NLELLDLGYNRIRS-------- 195
Cdd:PLN00113 299 EIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRlqvlqlwsnkfsgeipknlgkhnNLTVLDLSTNNLTGeipeglcs 378

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 196 --------LARNVFAGMI--------RLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLD 259
Cdd:PLN00113 379 sgnlfkliLFSNSLEGEIpkslgacrSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLS 458

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 109809759 260 LSGNEieaFSG--PSVFQCvPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGN 312
Cdd:PLN00113 459 LARNK---FFGglPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSEN 509
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-61 4.66e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.76  E-value: 4.66e-05
                           10        20
                   ....*....|....*....|....*....
gi 109809759    33 GCPKGCRCEGKMVYCESQKLQEIPSSISA 61
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPP 29
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 84-290 2.77e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 2.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  84 LNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLH 163
Cdd:PLN00113 187 LTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLF 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759 164 LRSNSLR-TIPVRIFqDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFS-KLNLAL--FPRLVSLQnlyLQWN 239
Cdd:PLN00113 267 LYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVALtsLPRLQVLQ---LWSN 342

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 109809759 240 KISVIGQTMSWTWSSLQRLDLSGNEIeafSG--PSVFQCVPNLQRLNLDSNKL 290
Cdd:PLN00113 343 KFSGEIPKNLGKHNNLTVLDLSTNNL---TGeiPEGLCSSGNLFKLILFSNSL 392
LRR_8 pfam13855
Leucine rich repeat;
253-312 2.82e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 2.82e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  253 SSLQRLDLSGNEIEAFSgPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGN 312
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD-DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 54-184 1.13e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.07  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759   54 EIPSSIS-------AGCLGL-SLR-YNSLQKLKYNQFKGLNqLTWLYLdHNHISNIDENAFNGIRRLKELILSSNrISYF 124
Cdd:pfam13306  17 TIPSSLTsigeyafSNCTSLkSITlPSSLTSIGSYAFYNCS-LTSITI-PSSLTSIGEYAFSNCSNLKSITLPSN-LTSI 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  125 LNNTFRPvTNLRNLDLsynqlhslgseqfrglrkllslhlrSNSLRTIPVRIFQDCRNLE 184
Cdd:pfam13306  94 GSYAFSN-CSLKSITI-------------------------PSSVTTIGSYAFSNCSNLK 127
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-60 1.53e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.07  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....*...
gi 109809759   33 GCPKGCRCEGKMVYCESQKLQEIPSSIS 60
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR_9 pfam14580
Leucine-rich repeat;
84-209 1.94e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.36  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759   84 LNQLTWLYLDHNHISNIDenAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGS-EQFRGLRKLLSL 162
Cdd:pfam14580  41 LDQFDTIDFSDNEIRKLD--GFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDlDPLASLKKLTFL 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 109809759  163 HLRSNSLRTIP---VRIFQDCRNLELLDlgYNRIRSLARNVFAGMIRLKE 209
Cdd:pfam14580 119 SLLRNPVTNKPhyrLYVIYKVPQLRLLD--FRKVKQKERQAAEKMFRSKQ 166
PLN03150 PLN03150
hypothetical protein; Provisional
 90-169 9.33e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.03  E-value: 9.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109809759  90 LYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSL 169
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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