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CCR4-NOT transcription complex subunit 1 isoform 2 [Mus musculus]
CCR4-NOT transcription complex subunit 1( domain architecture ID 13872477)
CCR4-NOT transcription complex subunit 1 is a scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation
List of domain hits
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Name | Accession | Description | Interval | E-value | |||||||||||||||||||||
CDC39 super family | cl34904 | Cell division control protein, negative regulator of transcription [Cell division and ... |
835-2364 | 0e+00 | |||||||||||||||||||||
Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]; The actual alignment was detected with superfamily member COG5103: Pssm-ID: 227434 [Multi-domain] Cd Length: 2005 Bit Score: 686.74 E-value: 0e+00
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CNOT1_HEAT | pfam16418 | CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in ... |
500-656 | 9.57e-55 | |||||||||||||||||||||
CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in CCR4-NOT transcription complex subunit 1. : Pssm-ID: 465113 Cd Length: 146 Bit Score: 187.81 E-value: 9.57e-55
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Name | Accession | Description | Interval | E-value | |||||||||||||||||||||
CDC39 | COG5103 | Cell division control protein, negative regulator of transcription [Cell division and ... |
835-2364 | 0e+00 | |||||||||||||||||||||
Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]; Pssm-ID: 227434 [Multi-domain] Cd Length: 2005 Bit Score: 686.74 E-value: 0e+00
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Not1 | pfam04054 | CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription ... |
1993-2348 | 0e+00 | |||||||||||||||||||||
CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID. Pssm-ID: 427680 Cd Length: 365 Bit Score: 594.11 E-value: 0e+00
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NOT1_connector | cd20710 | Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive ... |
1597-1809 | 1.90e-60 | |||||||||||||||||||||
Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive subunits of the multisubunit CCR4-NOT complex assembly that plays a central role in post-translational gene regulation in eukaryotes. CCR4-NOT contains the catalytic center formed by two deadenylase subunits CCR4 and CAF1, and the conserved core complex which contains a minimum of four catalytically inactive subunits, NOT1, NOT2, NOT3 and CAF40/NOT9. NOT1 is the largest subunit which functions as a central scaffold for complex assembly in human orthologs. The Chaetomium thermophilum NOT1 connector domain consists of five alpha-helical hairpin repeats of the HEAT type that structurally resemble MIF4G domains, and hence is also called the MIF4G-C domain. However, NOT1 MIF4G-C does not interact with DEAD-box helicases such as DDX6 like MIF4G does. Structural conservation of this domain suggests an important role but its function is as yet unknown. Pssm-ID: 411008 [Multi-domain] Cd Length: 202 Bit Score: 206.73 E-value: 1.90e-60
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CNOT1_HEAT | pfam16418 | CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in ... |
500-656 | 9.57e-55 | |||||||||||||||||||||
CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in CCR4-NOT transcription complex subunit 1. Pssm-ID: 465113 Cd Length: 146 Bit Score: 187.81 E-value: 9.57e-55
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Name | Accession | Description | Interval | E-value | |||||||||||||||||||||
CDC39 | COG5103 | Cell division control protein, negative regulator of transcription [Cell division and ... |
835-2364 | 0e+00 | |||||||||||||||||||||
Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]; Pssm-ID: 227434 [Multi-domain] Cd Length: 2005 Bit Score: 686.74 E-value: 0e+00
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Not1 | pfam04054 | CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription ... |
1993-2348 | 0e+00 | |||||||||||||||||||||
CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID. Pssm-ID: 427680 Cd Length: 365 Bit Score: 594.11 E-value: 0e+00
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CNOT1_CAF1_bind | pfam16415 | CCR4-NOT transcription complex subunit 1 CAF1-binding domain; This is the CAF1-binding domain ... |
1083-1307 | 3.06e-124 | |||||||||||||||||||||
CCR4-NOT transcription complex subunit 1 CAF1-binding domain; This is the CAF1-binding domain of CCR4-NOT transcription complex. It adopts a MIF4G (middle portion of eIF4G) fold. Pssm-ID: 465111 Cd Length: 225 Bit Score: 390.33 E-value: 3.06e-124
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CNOT1_TTP_bind | pfam16417 | CCR4-NOT transcription complex subunit 1 TTP binding domain; This is the TTP binding domain of ... |
816-999 | 9.84e-97 | |||||||||||||||||||||
CCR4-NOT transcription complex subunit 1 TTP binding domain; This is the TTP binding domain of CCR4-NOT transcription complex subunit 1. It adopts a MIF4G (middle portion of eIF4G) fold. Pssm-ID: 465112 Cd Length: 183 Bit Score: 309.92 E-value: 9.84e-97
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DUF3819 | pfam12842 | CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819; This is an uncharacterized ... |
1382-1528 | 6.96e-69 | |||||||||||||||||||||
CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819; This is an uncharacterized domain that is found on the CCR4-Not complex component Not1. Not1 is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID. Pssm-ID: 463726 Cd Length: 143 Bit Score: 228.17 E-value: 6.96e-69
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NOT1_connector | cd20710 | Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive ... |
1597-1809 | 1.90e-60 | |||||||||||||||||||||
Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive subunits of the multisubunit CCR4-NOT complex assembly that plays a central role in post-translational gene regulation in eukaryotes. CCR4-NOT contains the catalytic center formed by two deadenylase subunits CCR4 and CAF1, and the conserved core complex which contains a minimum of four catalytically inactive subunits, NOT1, NOT2, NOT3 and CAF40/NOT9. NOT1 is the largest subunit which functions as a central scaffold for complex assembly in human orthologs. The Chaetomium thermophilum NOT1 connector domain consists of five alpha-helical hairpin repeats of the HEAT type that structurally resemble MIF4G domains, and hence is also called the MIF4G-C domain. However, NOT1 MIF4G-C does not interact with DEAD-box helicases such as DDX6 like MIF4G does. Structural conservation of this domain suggests an important role but its function is as yet unknown. Pssm-ID: 411008 [Multi-domain] Cd Length: 202 Bit Score: 206.73 E-value: 1.90e-60
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CNOT1_HEAT | pfam16418 | CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in ... |
500-656 | 9.57e-55 | |||||||||||||||||||||
CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in CCR4-NOT transcription complex subunit 1. Pssm-ID: 465113 Cd Length: 146 Bit Score: 187.81 E-value: 9.57e-55
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Blast search parameters | ||||
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