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Conserved domains on  [gi|30795250|ref|NP_840055|]
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cysteine protease ATG4A isoform c [Homo sapiens]

Protein Classification

cysteine protease ATG4( domain architecture ID 10506323)

cysteine protease ATG4 is required in the cytoplasm for vacuole transport (Cvt) and autophagy

EC:  3.4.22.-
MEROPS:  C54
PubMed:  11517925

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Peptidase_C54 pfam03416
Peptidase family C54;
1-258 2.30e-133

Peptidase family C54;


:

Pssm-ID: 460915  Cd Length: 269  Bit Score: 379.54  E-value: 2.30e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795250     1 MLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGV-GEGKSIGEWFGPNTVAQVLK 79
Cdd:pfam03416  37 MLRSGQMLLAQALLRHHLGRDWRWGDPDEEEETYRKILSWFADDPSAPFSIHQIVQMGKeSSGKKPGEWFGPSTVAQILK 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795250    80 KLALFDEWNSLAVYVSMDNTVVIEDIKKMCRVLPLSadtagdrppdsltasnqskgtsaycSAWKPLLLIVPLRLGINQI 159
Cdd:pfam03416 117 KLVNADPWSGLAVYVASDGTVYKDDVRKLCAPNSAS-------------------------SGEKPLLILVPLRLGLDKI 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795250   160 NPVYVDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTeENGTVNDQTFHClQSPQRMNILNLDP 239
Cdd:pfam03416 172 NPVYIPALKALLSLPQSVGIIGGRPSSSLYFVGFQGDKLIYLDPHTTQPAVDV-SYTDFDLESYHC-KRPRKMPISKMDP 249
                         250
                  ....*....|....*....
gi 30795250   240 SVALGFFCKEEKDFDNWCS 258
Cdd:pfam03416 250 SMALGFYCRDEEDFEDFCS 268
 
Name Accession Description Interval E-value
Peptidase_C54 pfam03416
Peptidase family C54;
1-258 2.30e-133

Peptidase family C54;


Pssm-ID: 460915  Cd Length: 269  Bit Score: 379.54  E-value: 2.30e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795250     1 MLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGV-GEGKSIGEWFGPNTVAQVLK 79
Cdd:pfam03416  37 MLRSGQMLLAQALLRHHLGRDWRWGDPDEEEETYRKILSWFADDPSAPFSIHQIVQMGKeSSGKKPGEWFGPSTVAQILK 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795250    80 KLALFDEWNSLAVYVSMDNTVVIEDIKKMCRVLPLSadtagdrppdsltasnqskgtsaycSAWKPLLLIVPLRLGINQI 159
Cdd:pfam03416 117 KLVNADPWSGLAVYVASDGTVYKDDVRKLCAPNSAS-------------------------SGEKPLLILVPLRLGLDKI 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795250   160 NPVYVDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTeENGTVNDQTFHClQSPQRMNILNLDP 239
Cdd:pfam03416 172 NPVYIPALKALLSLPQSVGIIGGRPSSSLYFVGFQGDKLIYLDPHTTQPAVDV-SYTDFDLESYHC-KRPRKMPISKMDP 249
                         250
                  ....*....|....*....
gi 30795250   240 SVALGFFCKEEKDFDNWCS 258
Cdd:pfam03416 250 SMALGFYCRDEEDFEDFCS 268
 
Name Accession Description Interval E-value
Peptidase_C54 pfam03416
Peptidase family C54;
1-258 2.30e-133

Peptidase family C54;


Pssm-ID: 460915  Cd Length: 269  Bit Score: 379.54  E-value: 2.30e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795250     1 MLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGV-GEGKSIGEWFGPNTVAQVLK 79
Cdd:pfam03416  37 MLRSGQMLLAQALLRHHLGRDWRWGDPDEEEETYRKILSWFADDPSAPFSIHQIVQMGKeSSGKKPGEWFGPSTVAQILK 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795250    80 KLALFDEWNSLAVYVSMDNTVVIEDIKKMCRVLPLSadtagdrppdsltasnqskgtsaycSAWKPLLLIVPLRLGINQI 159
Cdd:pfam03416 117 KLVNADPWSGLAVYVASDGTVYKDDVRKLCAPNSAS-------------------------SGEKPLLILVPLRLGLDKI 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795250   160 NPVYVDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTeENGTVNDQTFHClQSPQRMNILNLDP 239
Cdd:pfam03416 172 NPVYIPALKALLSLPQSVGIIGGRPSSSLYFVGFQGDKLIYLDPHTTQPAVDV-SYTDFDLESYHC-KRPRKMPISKMDP 249
                         250
                  ....*....|....*....
gi 30795250   240 SVALGFFCKEEKDFDNWCS 258
Cdd:pfam03416 250 SMALGFYCRDEEDFEDFCS 268
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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