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Conserved domains on  [gi|263192221|ref|NP_848652|]
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N-acetylaspartate synthetase [Homo sapiens]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10003213)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 172-272 3.49e-18

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


:

Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 78.88  E-value: 3.49e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 263192221 172 IEQYYMKPPGSCFWVAVLDGNVVGIVAARAHEEDnTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVLGTTAv 251
Cdd:COG1246   18 IRPYALEEEIGEFWVAEEDGEIVGCAALHPLDED-LAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTS- 95

                         90       100
                 ....*....|....*....|.
gi 263192221 252 kvAAHKLYESLGFRHMGASDH 272
Cdd:COG1246   96 --AAIHFYEKLGFEEIDKEDL 114
 
Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 172-272 3.49e-18

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 78.88  E-value: 3.49e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 263192221 172 IEQYYMKPPGSCFWVAVLDGNVVGIVAARAHEEDnTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVLGTTAv 251
Cdd:COG1246   18 IRPYALEEEIGEFWVAEEDGEIVGCAALHPLDED-LAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTS- 95

                         90       100
                 ....*....|....*....|.
gi 263192221 252 kvAAHKLYESLGFRHMGASDH 272
Cdd:COG1246   96 --AAIHFYEKLGFEEIDKEDL 114
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 180-265 1.58e-14

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 67.48  E-value: 1.58e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 263192221  180 PGSCFWVAVLDGNVVGIVAARAHEEDNTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVLGTTavkVAAHKLY 259
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETT---NRAAAFY 77


                  ....*.
gi 263192221  260 ESLGFR 265
Cdd:pfam13508  78 EKLGFE 83
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 180-273 9.08e-08

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 50.02  E-value: 9.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 263192221  180 PGSCFWVAVLDGNVVGIVAAraHEEDNTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVLGTTAVKVAAHKLY 259
Cdd:TIGR01575  29 YHLCYLLARIGGKVVGYAGV--QIVLDEAHILNIAVKPEYQGQGIGRALLRELIDEAKGRGVNEIFLEVRVSNIAAQALY 106

                          90
                  ....*....|....
gi 263192221  260 ESLGFRHMGASDHY 273
Cdd:TIGR01575 107 KKLGFNEIAIRRNY 120
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 184-246 1.13e-07

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 48.04  E-value: 1.13e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 263192221 184 FWVAVLDGNVVG-IVAARAHEEDNTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVL 246
Cdd:cd04301    1 FLVAEDDGEIVGfASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRL 64
 
Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 172-272 3.49e-18

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 78.88  E-value: 3.49e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 263192221 172 IEQYYMKPPGSCFWVAVLDGNVVGIVAARAHEEDnTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVLGTTAv 251
Cdd:COG1246   18 IRPYALEEEIGEFWVAEEDGEIVGCAALHPLDED-LAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTS- 95

                         90       100
                 ....*....|....*....|.
gi 263192221 252 kvAAHKLYESLGFRHMGASDH 272
Cdd:COG1246   96 --AAIHFYEKLGFEEIDKEDL 114
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 170-284 3.21e-17

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 76.63  E-value: 3.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 263192221 170 ADIEQYYMKPPGSCFWVAVLDGNVVGIVAARaHEEDNTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVLGTT 249
Cdd:COG0454   22 AELKAMEGSLAGAEFIAVDDKGEPIGFAGLR-RLDDKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTL 100

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 263192221 250 AVKVAAHKLYESLGFRHMGASDHYVLPGMTLSLAE 284
Cdd:COG0454  101 DGNPAAIRFYERLGFKEIERYVAYVGGEFEKELSL 135
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 180-265 1.58e-14

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 67.48  E-value: 1.58e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 263192221  180 PGSCFWVAVLDGNVVGIVAARAHEEDNTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVLGTTavkVAAHKLY 259
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETT---NRAAAFY 77


                  ....*.
gi 263192221  260 ESLGFR 265
Cdd:pfam13508  78 EKLGFE 83
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 154-264 4.53e-14

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 67.54  E-value: 4.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 263192221  154 RKVIRAYLECALHTDMADIEQYYMKPPGSCFWVAVLDGNVVGIVAARA-HEEDNTVELLRMSVDSRFRGKGIAKALGRKV 232
Cdd:pfam00583   5 YELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIiDDEPPVGEIEGLAVAPEYRGKGIGTALLQAL 84

                          90       100       110
                  ....*....|....*....|....*....|..
gi 263192221  233 LEFAVVHNYSAVVLGTTAVKVAAHKLYESLGF 264
Cdd:pfam00583  85 LEWARERGCERIFLEVAADNLAAIALYEKLGF 116
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 195-278 9.36e-14

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 65.83  E-value: 9.36e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 263192221 195 GIVAARAHEEDNTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVLGTTAVKVAAHKLYESLGFRHMGASDHYV 274
Cdd:COG0456    1 GFALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYY 80


                 ....
gi 263192221 275 LPGM 278
Cdd:COG0456   81 GDDA 84
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
178-268 4.41e-13

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 65.79  E-value: 4.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 263192221 178 KPPGSCFWVAVLDGNVVGIVAARAHEE----DNTVELlRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVLGTTAVKV 253
Cdd:COG1247   48 LAPGRPVLVAEEDGEVVGFASLGPFRPrpayRGTAEE-SIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNE 126

                         90
                 ....*....|....*
gi 263192221 254 AAHKLYESLGFRHMG 268
Cdd:COG1247  127 ASIALYEKLGFEEVG 141
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
179-276 5.60e-13

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 65.11  E-value: 5.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 263192221 179 PPGSCFWVAVLDGNVVGIVA---ARAHEEDNTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVLGTTAvkvAA 255
Cdd:COG3153   36 PAAGLSLVAEDDGEIVGHVAlspVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDP---SL 112

                         90       100
                 ....*....|....*....|.
gi 263192221 256 HKLYESLGFRHMGASDHYVLP 276
Cdd:COG3153  113 LPFYERFGFRPAGELGLTLGP 133
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
193-276 1.75e-08

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 51.06  E-value: 1.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 263192221 193 VVGIVAARAHEeDNTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVLGTTAVKVAAHKLYESLGFRHMGASDH 272
Cdd:COG3393    2 LVAMAGVRAES-PGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPAARRLYERLGFRPVGEYAT 80


                 ....
gi 263192221 273 YVLP 276
Cdd:COG3393   81 VLFR 84
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 180-273 9.08e-08

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 50.02  E-value: 9.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 263192221  180 PGSCFWVAVLDGNVVGIVAAraHEEDNTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVLGTTAVKVAAHKLY 259
Cdd:TIGR01575  29 YHLCYLLARIGGKVVGYAGV--QIVLDEAHILNIAVKPEYQGQGIGRALLRELIDEAKGRGVNEIFLEVRVSNIAAQALY 106

                          90
                  ....*....|....
gi 263192221  260 ESLGFRHMGASDHY 273
Cdd:TIGR01575 107 KKLGFNEIAIRRNY 120
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 184-246 1.13e-07

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 48.04  E-value: 1.13e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 263192221 184 FWVAVLDGNVVG-IVAARAHEEDNTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVL 246
Cdd:cd04301    1 FLVAEDDGEIVGfASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRL 64
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
186-268 1.19e-07

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 49.80  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 263192221 186 VAVLDGNVVGIVAARaHEEDNTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVLGttaVKVAAHKLYESLGFR 265
Cdd:COG2153   38 LAYDDGELVATARLL-PPGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIVLS---AQAHAVGFYEKLGFV 113


                 ...
gi 263192221 266 HMG 268
Cdd:COG2153  114 PVG 116
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 152-275 1.47e-07

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 50.38  E-value: 1.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 263192221 152 YSRKVIRAYLECALHtdmadieqyYMKPPGSCFWVAVL--DGNVVGIVAA-RAHEEDNTVELlRMSVDSRFRGKGIAKAL 228
Cdd:COG1670   39 YSLEEARAWLERLLA---------DWADGGALPFAIEDkeDGELIGVVGLyDIDRANRSAEI-GYWLAPAYWGKGYATEA 108

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 263192221 229 GRKVLEFAV-VHNYSAVVLGTTAVKVAAHKLYESLGFRHMGASDHYVL 275
Cdd:COG1670  109 LRALLDYAFeELGLHRVEAEVDPDNTASIRVLEKLGFRLEGTLRDALV 156
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 184-265 1.02e-06

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 46.88  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 263192221  184 FWVAVLDGNVVGIVAARaheedNTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVLGTTAVKVAAhKLYESLG 263
Cdd:pfam13673  33 FFVAFEGGQIVGVIALR-----DRGHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTVNASPYAV-PFYEKLG 106


                  ..
gi 263192221  264 FR 265
Cdd:pfam13673 107 FR 108
YidJ COG2388
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
186-246 9.04e-04

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 441953 [Multi-domain]  Cd Length: 88  Bit Score: 37.44  E-value: 9.04e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 263192221 186 VAVLDGNVVGIVAARahEEDNTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVL 246
Cdd:COG2388   13 ELEVDGELAGELTYR--LEGGVIIITHTEVPPALRGQGIASALVEAALDDARERGLKVVPL 71
Acetyltransf_CG pfam14542
GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both ...
 184-246 1.55e-03

GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.


Pssm-ID: 434030 [Multi-domain]  Cd Length: 79  Bit Score: 36.73  E-value: 1.55e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 263192221  184 FWVAVLDGNVVGIVAARAHeeDNTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVL 246
Cdd:pfam14542   2 FEIRVDGGAEVAFLTYRRG--DGVLIITHTEVPPALRGQGIASKLVKAALDDAREEGLKIVPL 62
COG3981 COG3981
Predicted acetyltransferase [General function prediction only];
180-236 9.92e-03

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443180  Cd Length: 170  Bit Score: 36.04  E-value: 9.92e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 263192221 180 PGSCFWVAVLDGNVVGIVAARaHEEDntvELLR-------MSVDSRFRGKGIAKALGRKVLEFA 236
Cdd:COG3981   61 PATTYWLVDEDGRIVGAINLR-HELN---EFLLrvgghigYGVRPSERGKGYATEMLRLALEEA 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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