NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|47271479|ref|NP_849155|]
View 

sodium/hydrogen exchanger 9B2 isoform 1 [Homo sapiens]

Protein Classification

cation:proton antiporter( domain architecture ID 10000258)

cation:proton antiporter functions in maintaining cation homeostasis and the pH of actively metabolizing cells; it may also be involved in regulating cell volume; similar to NhaP-type Na+/H+ or K+/H+ antiporter

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
160-530 1.19e-41

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


:

Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 156.28  E-value: 1.19e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 160 PVINDNVQIKHKWSSSLRSIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAHYLLGLPWQWGFILGF 239
Cdd:COG0025  41 PGLGLELDPELGDLEPLLELFLPPLLFEAALNLDLRELRRNGRPILRLAVVGVLLTTLAVALAAHWLLGLPLAAALLLGA 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 240 VLGAVSPAVVVPSMlllqgGGYGVEKGVPTLLMAAGSFDDILAITGFNTCLGIAFSTGSTVFNVLRGVL-EVVIGVATGS 318
Cdd:COG0025 121 ILAPTDPVAVSPIL-----RRLGVPKRLRTILEGESLLNDATALVLFVLALAAALGGGFSLGEALLDFLlAILGGILVGL 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 319 VLGFFIQYFPSRDQDKLVckRTFLVLGLSVLAVFSSVHFGfpGSGGLCTLVMAF-LAGMGWTSEKAEVEKIIAVAWD--- 394
Cdd:COG0025 196 LLGWLLGRLLRRLPDPLL--EILLTLALPFLAYLLAEALH--GSGVLAVVVAGLvLGNAGRRSLSPETRLQLLEFWEtle 271
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 395 -IFQPLLFGLIGAEVSIASLRPETVGLCVATVGIAVLIRILTTFLMVCFAG--FNLKEKIFISFAwLPKATVQAAIGSVA 471
Cdd:COG0025 272 fLLNSLLFVLLGAQLPLILLGALGLGGILLVLLALLVVRPLWVFLSLALRGsrLSWRERLFLSWG-GPRGIVSLALALSL 350
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47271479 472 LDTARSHGEkqledYGMDVLTVAFLSILITAPIGSLLIGLLGPRLLQKVEHQNKDEEVQ 530
Cdd:COG0025 351 PLHGGAGFP-----GRDLILALAFGVILLTLVLQGLTLPPLARRLGLREDEPEGEELEA 404
 
Name Accession Description Interval E-value
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
160-530 1.19e-41

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 156.28  E-value: 1.19e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 160 PVINDNVQIKHKWSSSLRSIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAHYLLGLPWQWGFILGF 239
Cdd:COG0025  41 PGLGLELDPELGDLEPLLELFLPPLLFEAALNLDLRELRRNGRPILRLAVVGVLLTTLAVALAAHWLLGLPLAAALLLGA 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 240 VLGAVSPAVVVPSMlllqgGGYGVEKGVPTLLMAAGSFDDILAITGFNTCLGIAFSTGSTVFNVLRGVL-EVVIGVATGS 318
Cdd:COG0025 121 ILAPTDPVAVSPIL-----RRLGVPKRLRTILEGESLLNDATALVLFVLALAAALGGGFSLGEALLDFLlAILGGILVGL 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 319 VLGFFIQYFPSRDQDKLVckRTFLVLGLSVLAVFSSVHFGfpGSGGLCTLVMAF-LAGMGWTSEKAEVEKIIAVAWD--- 394
Cdd:COG0025 196 LLGWLLGRLLRRLPDPLL--EILLTLALPFLAYLLAEALH--GSGVLAVVVAGLvLGNAGRRSLSPETRLQLLEFWEtle 271
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 395 -IFQPLLFGLIGAEVSIASLRPETVGLCVATVGIAVLIRILTTFLMVCFAG--FNLKEKIFISFAwLPKATVQAAIGSVA 471
Cdd:COG0025 272 fLLNSLLFVLLGAQLPLILLGALGLGGILLVLLALLVVRPLWVFLSLALRGsrLSWRERLFLSWG-GPRGIVSLALALSL 350
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47271479 472 LDTARSHGEkqledYGMDVLTVAFLSILITAPIGSLLIGLLGPRLLQKVEHQNKDEEVQ 530
Cdd:COG0025 351 PLHGGAGFP-----GRDLILALAFGVILLTLVLQGLTLPPLARRLGLREDEPEGEELEA 404
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
172-512 5.85e-23

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 100.79  E-value: 5.85e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479   172 WSSSLRSIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAHYL-LGLPWQWGFILGFVLGAVSPAVVV 250
Cdd:pfam00999  47 DLEVLSNLGLPPLLFLAGLELDLRELRKNGGSILLLALLGVLIPFVLIGLLLYLLgLGIPLLEALLFGAILSATSPVVVL 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479   251 PSMLLLQGggygVEKGVPTLLMAAGSFDDILAITGFNTCLGIAFSTGSTVFNVLRGVLEVVIGVAtGSVLGFFIQYFPSR 330
Cdd:pfam00999 127 AILKELGR----VPERLGTLLLGESVLNDGVAVVLLAVLLALAQGVGGGSDLGWLLLIFLVVAVG-GLLLGLLIGWLLRL 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479   331 DQDKLVCKR---TFLVLGLSVLAVFSSVHFGFPGsgglctLVMAFLAGM----GWTSEKAEvEKIIAVAWDIFQPLLFGL 403
Cdd:pfam00999 202 ITRFTDDDReleVLLVLLLALLAALLAEALGVSG------ILGAFLAGLvlseYPFANKLS-EKLEPFGYGLFNPLFFVL 274
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479   404 IGAEVSIASLRPETVGLCVATVGIAVLIRILTTFLMVCFAGFNLKEKIFISFAWLPKATVQAAIGSVALdtarshgekQL 483
Cdd:pfam00999 275 VGLSLDLSSLLLSVWILVLLALVAILLGRFLGVFLLLRLLGLSLREALIIGFGGLQRGAVSLALAAIGP---------LL 345
                         330       340
                  ....*....|....*....|....*....
gi 47271479   484 EDYGMDVLTVAFLSILITAPIGSLLIGLL 512
Cdd:pfam00999 346 GIIARELYPLLIVVVLFTVLVQGITLKPL 374
PRK05326 PRK05326
potassium/proton antiporter;
178-458 1.53e-07

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 54.05  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479  178 SIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAHYLLGLPWQWGFILGFVLGAVSPAVVvpsMLLLQ 257
Cdd:PRK05326  64 NLALAVILFDGGLRTRWSSFRPALGPALSLATLGVLITAGLTGLFAHWLLGLDWLEGLLLGAIVGSTDAAAV---FSLLR 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479  258 GGGYGVEKGVPTLLMAAGSFDDILAItgFNTCLGIAFSTGSTVFNVLRGVLEVVIGVATGSVLGFFIQYFPSrdqdKLVC 337
Cdd:PRK05326 141 GKGLNLKERVASTLEIESGSNDPMAV--FLTITLIELITGGETGLSWGFLLLFLQQFGLGALIGLLGGWLLV----QLLN 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479  338 KRTFLVLGLSVLAVFSSVHFGFP------GSGGLCTLVMAFLAGMGWTSEKAEVEKII-AVAWdIFQPLLFGLIGAEVSI 410
Cdd:PRK05326 215 RIALPAEGLYPILVLAGALLIFAltaalgGSGFLAVYLAGLVLGNRPIRHRHSILRFFdGLAW-LAQIGMFLVLGLLVTP 293
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 47271479  411 ASLRPETV-GLCVAtVGIAVLIRILTTFLMVCFAGFNLKEKIFISFAWL 458
Cdd:PRK05326 294 SRLLDIALpALLLA-LFLILVARPLAVFLSLLPFRFNLREKLFISWVGL 341
 
Name Accession Description Interval E-value
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
160-530 1.19e-41

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 156.28  E-value: 1.19e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 160 PVINDNVQIKHKWSSSLRSIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAHYLLGLPWQWGFILGF 239
Cdd:COG0025  41 PGLGLELDPELGDLEPLLELFLPPLLFEAALNLDLRELRRNGRPILRLAVVGVLLTTLAVALAAHWLLGLPLAAALLLGA 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 240 VLGAVSPAVVVPSMlllqgGGYGVEKGVPTLLMAAGSFDDILAITGFNTCLGIAFSTGSTVFNVLRGVL-EVVIGVATGS 318
Cdd:COG0025 121 ILAPTDPVAVSPIL-----RRLGVPKRLRTILEGESLLNDATALVLFVLALAAALGGGFSLGEALLDFLlAILGGILVGL 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 319 VLGFFIQYFPSRDQDKLVckRTFLVLGLSVLAVFSSVHFGfpGSGGLCTLVMAF-LAGMGWTSEKAEVEKIIAVAWD--- 394
Cdd:COG0025 196 LLGWLLGRLLRRLPDPLL--EILLTLALPFLAYLLAEALH--GSGVLAVVVAGLvLGNAGRRSLSPETRLQLLEFWEtle 271
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 395 -IFQPLLFGLIGAEVSIASLRPETVGLCVATVGIAVLIRILTTFLMVCFAG--FNLKEKIFISFAwLPKATVQAAIGSVA 471
Cdd:COG0025 272 fLLNSLLFVLLGAQLPLILLGALGLGGILLVLLALLVVRPLWVFLSLALRGsrLSWRERLFLSWG-GPRGIVSLALALSL 350
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47271479 472 LDTARSHGEkqledYGMDVLTVAFLSILITAPIGSLLIGLLGPRLLQKVEHQNKDEEVQ 530
Cdd:COG0025 351 PLHGGAGFP-----GRDLILALAFGVILLTLVLQGLTLPPLARRLGLREDEPEGEELEA 404
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
172-512 5.85e-23

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 100.79  E-value: 5.85e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479   172 WSSSLRSIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAHYL-LGLPWQWGFILGFVLGAVSPAVVV 250
Cdd:pfam00999  47 DLEVLSNLGLPPLLFLAGLELDLRELRKNGGSILLLALLGVLIPFVLIGLLLYLLgLGIPLLEALLFGAILSATSPVVVL 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479   251 PSMLLLQGggygVEKGVPTLLMAAGSFDDILAITGFNTCLGIAFSTGSTVFNVLRGVLEVVIGVAtGSVLGFFIQYFPSR 330
Cdd:pfam00999 127 AILKELGR----VPERLGTLLLGESVLNDGVAVVLLAVLLALAQGVGGGSDLGWLLLIFLVVAVG-GLLLGLLIGWLLRL 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479   331 DQDKLVCKR---TFLVLGLSVLAVFSSVHFGFPGsgglctLVMAFLAGM----GWTSEKAEvEKIIAVAWDIFQPLLFGL 403
Cdd:pfam00999 202 ITRFTDDDReleVLLVLLLALLAALLAEALGVSG------ILGAFLAGLvlseYPFANKLS-EKLEPFGYGLFNPLFFVL 274
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479   404 IGAEVSIASLRPETVGLCVATVGIAVLIRILTTFLMVCFAGFNLKEKIFISFAWLPKATVQAAIGSVALdtarshgekQL 483
Cdd:pfam00999 275 VGLSLDLSSLLLSVWILVLLALVAILLGRFLGVFLLLRLLGLSLREALIIGFGGLQRGAVSLALAAIGP---------LL 345
                         330       340
                  ....*....|....*....|....*....
gi 47271479   484 EDYGMDVLTVAFLSILITAPIGSLLIGLL 512
Cdd:pfam00999 346 GIIARELYPLLIVVVLFTVLVQGITLKPL 374
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
179-515 1.12e-16

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 81.73  E-value: 1.12e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 179 IALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAhYLLGLPWQWGFILGFVLGAVSPAVVVPSM--LLL 256
Cdd:COG0475  61 LGVVLLLFLIGLELDLKRLRKMGRRALGIGLLQVLLPFLLGFLLA-LLLGLSLAAALFLGAALAATSTAIVLKVLkeLGL 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 257 QGGGYGvekgvpTLLMAAGSFDDILAITGFNTCLGIA---FSTGSTVFNVLRGVLEVVIGVATGSVLG-FFIQYFPSRDQ 332
Cdd:COG0475 140 LKTPLG------QLILGVALFDDIAAILLLALVPALAgggSVAGSLLLALLKALLFLALLLLVGRYLLrRLFRLVARTRS 213
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 333 DKLVckrTFLVLGLSVLAVFSSVHFGFPgsgglcTLVMAFLAGM--GWTSEKAEVEKIIAVAWDIFQPLLFGLIGAEVSI 410
Cdd:COG0475 214 RELF---LLFALLLVLLAAALAELLGLS------AALGAFLAGLvlAESEYRHELEEKIEPFGDLFLPLFFVSVGLSLDL 284
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 411 ASLrPETVGLCVATVGIAVLIRILTTFLMVCFAGFNLKEKIFISFAWLPKATVQAAIGSVALdtarshgekQLEDYGMDV 490
Cdd:COG0475 285 SAL-LSNPLLALLLVLAAIVGKLLGAYLAARLFGLSRREALRIGLLLAPRGEFALVLASLGL---------SAGLISPEL 354
                       330       340
                ....*....|....*....|....*
gi 47271479 491 LTVAFLSILITAPIGSLLIGLLGPR 515
Cdd:COG0475 355 FAALVLVVLLTTLLTPLLLRLALRL 379
PRK05326 PRK05326
potassium/proton antiporter;
178-458 1.53e-07

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 54.05  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479  178 SIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAHYLLGLPWQWGFILGFVLGAVSPAVVvpsMLLLQ 257
Cdd:PRK05326  64 NLALAVILFDGGLRTRWSSFRPALGPALSLATLGVLITAGLTGLFAHWLLGLDWLEGLLLGAIVGSTDAAAV---FSLLR 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479  258 GGGYGVEKGVPTLLMAAGSFDDILAItgFNTCLGIAFSTGSTVFNVLRGVLEVVIGVATGSVLGFFIQYFPSrdqdKLVC 337
Cdd:PRK05326 141 GKGLNLKERVASTLEIESGSNDPMAV--FLTITLIELITGGETGLSWGFLLLFLQQFGLGALIGLLGGWLLV----QLLN 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479  338 KRTFLVLGLSVLAVFSSVHFGFP------GSGGLCTLVMAFLAGMGWTSEKAEVEKII-AVAWdIFQPLLFGLIGAEVSI 410
Cdd:PRK05326 215 RIALPAEGLYPILVLAGALLIFAltaalgGSGFLAVYLAGLVLGNRPIRHRHSILRFFdGLAW-LAQIGMFLVLGLLVTP 293
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 47271479  411 ASLRPETV-GLCVAtVGIAVLIRILTTFLMVCFAGFNLKEKIFISFAWL 458
Cdd:PRK05326 294 SRLLDIALpALLLA-LFLILVARPLAVFLSLLPFRFNLREKLFISWVGL 341
NhaP2 COG3263
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ...
178-456 2.19e-06

NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 442494 [Multi-domain]  Cd Length: 502  Bit Score: 50.11  E-value: 2.19e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 178 SIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAHYLLGLPWQWGFILGFVLGAVSPAVVvpsMLLLQ 257
Cdd:COG3263  64 SLALAVILFDGGLRTRWSSFRPVLAPALSLATLGVLLTAGLTGVFAHWLLGLSWLEGLLLGAIVSSTDAAAV---FSILR 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 258 GGGYGVEKGV-PTLLMAAGSFDD--ILAITGFntcLGIAFSTGSTVFNVLRG-VLEVVIGVATGSVLGFFIQYFPSR--- 330
Cdd:COG3263 141 SKGLNLKERLaSTLELESGSNDPmaVFLTIAL---IELITGGGASGWSLLLLfVLQMGLGALVGLAGGWLGVWLLNRirl 217
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271479 331 DQDKLVckrTFLVLGLSVLAvfssvhFGFP----GSGGLCTLVMAFLAGMGWTSEKAEVEKII-AVAWdIFQPLLFGLIG 405
Cdd:COG3263 218 PAEGLY---PVLVLALALLA------FGATallgGSGFLAVYLAGLVLGNRRLPHKKSILRFHdGLAW-LAQIGMFLMLG 287
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 47271479 406 AEVSIASLRPETV-GLCVATVGIaVLIRILTTFLMVCFAGFNLKEKIFISFA 456
Cdd:COG3263 288 LLVFPSRLLPVALpALLIALFLI-FVARPLAVFLSLLPFRFSWREKLFISWV 338
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH