NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the domain plays a role in controlling axon branching in neural development, while the common function of these modules in TIMPs appears to be binding to metzincins. A subset of this family is also known as the C345C domain because it occurs as a C-terminal domain in complement C3, C4 and C5. In C5, the domain interacts with various partners during the formation of the membrane attack complex.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149944459   1 MNRLYLTPDGFFFRVHMLALDssscnKPCPEFKPGSRYIVMGHIYH-KRRQLPTAllQVLRGRLRPGDGLLRSSSS 75
Cdd:cd03576   53 EGRLAITQAGKTMSVKITVVC-----KQCPLLRRGLNYILMGQVDEeGRGVIPPE--SFVMLYKTKHQKLLAALSN 121

NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which have been suggested to possess inhibitory functions towards specific serine proteases but not towards metzincins, which are inhibited by the related TIMPs.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149944459   1 MNRLYLTPDGFFFRVHMLALDssscnKPCPEFKPGSRYIVMGHIYH-KRRQLPTAllQVLRGRLRPGDGLLRSSSS 75
Cdd:cd03576   53 EGRLAITQAGKTMSVKITVVC-----KQCPLLRRGLNYILMGQVDEeGRGVIPPE--SFVMLYKTKHQKLLAALSN 121

NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which have been suggested to possess inhibitory functions towards specific serine proteases but not towards metzincins, which are inhibited by the related TIMPs.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149944459   1 MNRLYLTPDGFFFRVHMLALDssscnKPCPEFKPGSRYIVMGHIYH-KRRQLPTAllQVLRGRLRPGDGLLRSSSS 75
Cdd:cd03576   53 EGRLAITQAGKTMSVKITVVC-----KQCPLLRRGLNYILMGQVDEeGRGVIPPE--SFVMLYKTKHQKLLAALSN 121