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Conserved domains on  [gi|32171215|ref|NP_859066|]
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CREB-regulated transcription coactivator 2 [Homo sapiens]

Protein Classification

CREB-regulated transcription coactivator( domain architecture ID 10583816)

CREB-regulated transcription coactivator enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TORC_M pfam12885
Transducer of regulated CREB activity middle domain; This family includes the region between ...
 168-320 1.36e-52

Transducer of regulated CREB activity middle domain; This family includes the region between the N and C terminus of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). Although the C- and N- terminal domains of these proteins have been well characterized, no functional role has been assigned to the central region, yet.


:

Pssm-ID: 463739  Cd Length: 154  Bit Score: 178.40  E-value: 1.36e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171215   168 RTSSDSALHTSVMNPSPQDTYPGPTPPSILPSRRGGIldgEMDPKVPAIEENLLDDKHLL--KPWDAKKLSSSSSRPRSC 245
Cdd:pfam12885   1 RTNSDSALHTSAMNPNPQDPFTGGSQELQPAPRGFGR---VLLLTVPGTEENLLEVDKPLpkQLWDAKKVQSLSSRPKSC 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 32171215   246 EVPGINIFPSPDQPANVPVLPPAMNTGGSLPDLTNLHFPPPLPTPLDPEETAYPSLSGGNSTSNLTHTMTHLGIS 320
Cdd:pfam12885  78 EVPGINIFPSPDQNATLSLFPAALNTGGSLPDLTNLHFPSPLPTPLDPEDTAFPSLSGGNSTGNLAAAMTHLGIS 152
TORC_C pfam12886
Transducer of regulated CREB activity, C terminus; This family includes the C terminal region ...
 615-692 1.23e-31

Transducer of regulated CREB activity, C terminus; This family includes the C terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). The C terminus region is negatively charged, resembling the transcription activation domains. When this domain, from all three human TORC proteins, was expressed as fusion proteins with the DNA-binding domain of GAL4 (GAL4-BD), and tested for induction of a minimal promoter linked to GAL4-binding sites (UAS-GAL4), UAS-GAL4 was potently induced by GAL4-BD fusions containing the C-terminal portion of all three human TORCs.


:

Pssm-ID: 463740  Cd Length: 75  Bit Score: 117.50  E-value: 1.23e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 32171215   615 PNIILTGDSSPGFSKEIAAALAGVPGFEVSAAGLelgLGLEDELRMEPLGLEGLNMLSDPCALLPDPAVEESFRSDRL 692
Cdd:pfam12886   1 PNIILTGDSSPGFSKDLSSALAGVPEVSFDADDL---FPLDDELGIEPLDLDGLQMLSDPDMVLPDPATEDTFRSDRL 75
TORC_N pfam12884
Transducer of regulated CREB activity, N terminus; This family includes the N terminal region ...
 18-72 1.05e-18

Transducer of regulated CREB activity, N terminus; This family includes the N terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). The proteins display a highly conserved predicted N-terminal coiled-coil domain and an invariant sequence matching a protein kinase A (PKA) phosphorylation consensus sequence (RKXS). The coiled-coil structure interacts with the bZIP domain of CREB. This interaction may occur via ionic bonds because it is disrupted under high-salt conditions. In addition to CREB-binding, the N-terminal region plays a role in the tetramer formation of TORCs, but the physiological function of the multimeric complex has not been clarified yet.


:

Pssm-ID: 463738  Cd Length: 63  Bit Score: 80.19  E-value: 1.05e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32171215    18 NPRKFSEKIALQKQRQAEETAAFEEVMMDI--------GSTRLQAQKLRLAYTRSSHYGGSLP 72
Cdd:pfam12884   1 NPRKFSEKIALHKQKQAEETAAFERIMREVsattrdptQSSNQKQQQLRLGLLGPQYRGGSLP 63
 
Name Accession Description Interval E-value
TORC_M pfam12885
Transducer of regulated CREB activity middle domain; This family includes the region between ...
 168-320 1.36e-52

Transducer of regulated CREB activity middle domain; This family includes the region between the N and C terminus of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). Although the C- and N- terminal domains of these proteins have been well characterized, no functional role has been assigned to the central region, yet.


Pssm-ID: 463739  Cd Length: 154  Bit Score: 178.40  E-value: 1.36e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171215   168 RTSSDSALHTSVMNPSPQDTYPGPTPPSILPSRRGGIldgEMDPKVPAIEENLLDDKHLL--KPWDAKKLSSSSSRPRSC 245
Cdd:pfam12885   1 RTNSDSALHTSAMNPNPQDPFTGGSQELQPAPRGFGR---VLLLTVPGTEENLLEVDKPLpkQLWDAKKVQSLSSRPKSC 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 32171215   246 EVPGINIFPSPDQPANVPVLPPAMNTGGSLPDLTNLHFPPPLPTPLDPEETAYPSLSGGNSTSNLTHTMTHLGIS 320
Cdd:pfam12885  78 EVPGINIFPSPDQNATLSLFPAALNTGGSLPDLTNLHFPSPLPTPLDPEDTAFPSLSGGNSTGNLAAAMTHLGIS 152
TORC_C pfam12886
Transducer of regulated CREB activity, C terminus; This family includes the C terminal region ...
 615-692 1.23e-31

Transducer of regulated CREB activity, C terminus; This family includes the C terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). The C terminus region is negatively charged, resembling the transcription activation domains. When this domain, from all three human TORC proteins, was expressed as fusion proteins with the DNA-binding domain of GAL4 (GAL4-BD), and tested for induction of a minimal promoter linked to GAL4-binding sites (UAS-GAL4), UAS-GAL4 was potently induced by GAL4-BD fusions containing the C-terminal portion of all three human TORCs.


Pssm-ID: 463740  Cd Length: 75  Bit Score: 117.50  E-value: 1.23e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 32171215   615 PNIILTGDSSPGFSKEIAAALAGVPGFEVSAAGLelgLGLEDELRMEPLGLEGLNMLSDPCALLPDPAVEESFRSDRL 692
Cdd:pfam12886   1 PNIILTGDSSPGFSKDLSSALAGVPEVSFDADDL---FPLDDELGIEPLDLDGLQMLSDPDMVLPDPATEDTFRSDRL 75
TORC_N pfam12884
Transducer of regulated CREB activity, N terminus; This family includes the N terminal region ...
 18-72 1.05e-18

Transducer of regulated CREB activity, N terminus; This family includes the N terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). The proteins display a highly conserved predicted N-terminal coiled-coil domain and an invariant sequence matching a protein kinase A (PKA) phosphorylation consensus sequence (RKXS). The coiled-coil structure interacts with the bZIP domain of CREB. This interaction may occur via ionic bonds because it is disrupted under high-salt conditions. In addition to CREB-binding, the N-terminal region plays a role in the tetramer formation of TORCs, but the physiological function of the multimeric complex has not been clarified yet.


Pssm-ID: 463738  Cd Length: 63  Bit Score: 80.19  E-value: 1.05e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32171215    18 NPRKFSEKIALQKQRQAEETAAFEEVMMDI--------GSTRLQAQKLRLAYTRSSHYGGSLP 72
Cdd:pfam12884   1 NPRKFSEKIALHKQKQAEETAAFERIMREVsattrdptQSSNQKQQQLRLGLLGPQYRGGSLP 63
 
Name Accession Description Interval E-value
TORC_M pfam12885
Transducer of regulated CREB activity middle domain; This family includes the region between ...
 168-320 1.36e-52

Transducer of regulated CREB activity middle domain; This family includes the region between the N and C terminus of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). Although the C- and N- terminal domains of these proteins have been well characterized, no functional role has been assigned to the central region, yet.


Pssm-ID: 463739  Cd Length: 154  Bit Score: 178.40  E-value: 1.36e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171215   168 RTSSDSALHTSVMNPSPQDTYPGPTPPSILPSRRGGIldgEMDPKVPAIEENLLDDKHLL--KPWDAKKLSSSSSRPRSC 245
Cdd:pfam12885   1 RTNSDSALHTSAMNPNPQDPFTGGSQELQPAPRGFGR---VLLLTVPGTEENLLEVDKPLpkQLWDAKKVQSLSSRPKSC 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 32171215   246 EVPGINIFPSPDQPANVPVLPPAMNTGGSLPDLTNLHFPPPLPTPLDPEETAYPSLSGGNSTSNLTHTMTHLGIS 320
Cdd:pfam12885  78 EVPGINIFPSPDQNATLSLFPAALNTGGSLPDLTNLHFPSPLPTPLDPEDTAFPSLSGGNSTGNLAAAMTHLGIS 152
TORC_C pfam12886
Transducer of regulated CREB activity, C terminus; This family includes the C terminal region ...
 615-692 1.23e-31

Transducer of regulated CREB activity, C terminus; This family includes the C terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). The C terminus region is negatively charged, resembling the transcription activation domains. When this domain, from all three human TORC proteins, was expressed as fusion proteins with the DNA-binding domain of GAL4 (GAL4-BD), and tested for induction of a minimal promoter linked to GAL4-binding sites (UAS-GAL4), UAS-GAL4 was potently induced by GAL4-BD fusions containing the C-terminal portion of all three human TORCs.


Pssm-ID: 463740  Cd Length: 75  Bit Score: 117.50  E-value: 1.23e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 32171215   615 PNIILTGDSSPGFSKEIAAALAGVPGFEVSAAGLelgLGLEDELRMEPLGLEGLNMLSDPCALLPDPAVEESFRSDRL 692
Cdd:pfam12886   1 PNIILTGDSSPGFSKDLSSALAGVPEVSFDADDL---FPLDDELGIEPLDLDGLQMLSDPDMVLPDPATEDTFRSDRL 75
TORC_N pfam12884
Transducer of regulated CREB activity, N terminus; This family includes the N terminal region ...
 18-72 1.05e-18

Transducer of regulated CREB activity, N terminus; This family includes the N terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). The proteins display a highly conserved predicted N-terminal coiled-coil domain and an invariant sequence matching a protein kinase A (PKA) phosphorylation consensus sequence (RKXS). The coiled-coil structure interacts with the bZIP domain of CREB. This interaction may occur via ionic bonds because it is disrupted under high-salt conditions. In addition to CREB-binding, the N-terminal region plays a role in the tetramer formation of TORCs, but the physiological function of the multimeric complex has not been clarified yet.


Pssm-ID: 463738  Cd Length: 63  Bit Score: 80.19  E-value: 1.05e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32171215    18 NPRKFSEKIALQKQRQAEETAAFEEVMMDI--------GSTRLQAQKLRLAYTRSSHYGGSLP 72
Cdd:pfam12884   1 NPRKFSEKIALHKQKQAEETAAFERIMREVsattrdptQSSNQKQQQLRLGLLGPQYRGGSLP 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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