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Conserved domains on  [gi|116325987|ref|NP_872409|]
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ankyrin repeat domain-containing protein 42 isoform 4 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 14296095)

ankyrin (ANK) repeat domain-containing protein may be involved in mediating protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
30-236 1.06e-30

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.90  E-value: 1.06e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  30 IHDAVRAGDVKqlseivCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHG 109
Cdd:COG0666   91 LHAAARNGDLE------IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 110 HSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMss 189
Cdd:COG0666  165 NLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG-- 242

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 116325987 190 ATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETL 236
Cdd:COG0666  243 ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
169-300 8.56e-11

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.20  E-value: 8.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  169 HLAAMEGHLHCFKFLVSRMSSATQVlkafNDNGENVLdlaqrffkqnilqfiqgaeyegkdledqetlafpgHVAAFKGD 248
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQ----DKNGRTAL-----------------------------------HLAAKNGH 42

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 116325987  249 LGMLKKLVEDGVININeraDNGSTPMHKAAGQGHIECLQWLIKMGADSNITN 300
Cdd:pfam12796  43 LEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA03100 super family cl39094
ankyrin repeat protein; Provisional
 252-357 5.11e-06

ankyrin repeat protein; Provisional


The actual alignment was detected with superfamily member PHA03100:

Pssm-ID: 476869 [Multi-domain]  Cd Length: 422  Bit Score: 48.12  E-value: 5.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 252 LKKLVEDGViNINERADNGSTPMHKAAGQ--GHIECLQWLIKMGADSNITNKAGERPSDVAKRFAH--LAAVKLLEElQK 327
Cdd:PHA03100  89 VKLLLEYGA-NVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLID-KG 166

                         90       100       110
                 ....*....|....*....|....*....|
gi 116325987 328 YDIDDENEIDendvkYFIRHGVegSTDAKD 357
Cdd:PHA03100 167 VDINAKNRVN-----YLLSYGV--PINIKD 189
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
30-236 1.06e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.90  E-value: 1.06e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  30 IHDAVRAGDVKqlseivCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHG 109
Cdd:COG0666   91 LHAAARNGDLE------IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 110 HSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMss 189
Cdd:COG0666  165 NLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG-- 242

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 116325987 190 ATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETL 236
Cdd:COG0666  243 ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
70-161 5.81e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.46  E-value: 5.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987   70 HIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLrSGVDPSVTDKReWRPVHYAAFHGRLGCLQL 149
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKDNG-RTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 116325987  150 LVKWGCSIEDVD 161
Cdd:pfam12796  80 LLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 32-363 6.60e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 72.69  E-value: 6.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  32 DAVRAGDVKqlseIVCLhwLLWHGADITHVTTRG----WTASHIAA--------IRGQDACV-----------QALIMNG 88
Cdd:PHA02874  41 DAIRSGDAK----IVEL--FIKHGADINHINTKIphplLTAIKIGAhdiiklliDNGVDTSIlpipciekdmiKTILDCG 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  89 ANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPV 168
Cdd:PHA02874 115 IDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 169 HLAAMEGHLHCFKFLVsrmssatqvlkafnDNGENVLDLAQRFFKqnilqfiqgaeyegkdledqetlafPGHVAAFKgD 248
Cdd:PHA02874 195 HNAAEYGDYACIKLLI--------------DHGNHIMNKCKNGFT-------------------------PLHNAIIH-N 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 249 LGMLKKLVEDGVININERadNGSTPMHKAAGQG-HIECLQWLIKMGADSNITNKAGERPSDVAKRF-----------AHL 316
Cdd:PHA02874 235 RSAIELLINNASINDQDI--DGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKYinkdpvikdiiANA 312

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 116325987 317 AAVKLLEELQKYDIDDENEIDENDV-KYFIRHGVEGSTDAKDDLCLSD 363
Cdd:PHA02874 313 VLIKEADKLKDSDFLEHIEIKDNKEfSDFIKECNEEIEDMKKTKCGCD 360
Ank_2 pfam12796
Ankyrin repeats (3 copies);
169-300 8.56e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.20  E-value: 8.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  169 HLAAMEGHLHCFKFLVSRMSSATQVlkafNDNGENVLdlaqrffkqnilqfiqgaeyegkdledqetlafpgHVAAFKGD 248
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQ----DKNGRTAL-----------------------------------HLAAKNGH 42

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 116325987  249 LGMLKKLVEDGVININeraDNGSTPMHKAAGQGHIECLQWLIKMGADSNITN 300
Cdd:pfam12796  43 LEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 252-357 5.11e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.12  E-value: 5.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 252 LKKLVEDGViNINERADNGSTPMHKAAGQ--GHIECLQWLIKMGADSNITNKAGERPSDVAKRFAH--LAAVKLLEElQK 327
Cdd:PHA03100  89 VKLLLEYGA-NVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLID-KG 166

                         90       100       110
                 ....*....|....*....|....*....|
gi 116325987 328 YDIDDENEIDendvkYFIRHGVegSTDAKD 357
Cdd:PHA03100 167 VDINAKNRVN-----YLLSYGV--PINIKD 189
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 241-322 9.68e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.50  E-value: 9.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 241 HVAAfKGDLGMLKKLVEDGViNINERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVK 320
Cdd:PTZ00322  88 QLAA-SGDAVGARILLTGGA-DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165


                 ..
gi 116325987 321 LL 322
Cdd:PTZ00322 166 LL 167
Ank_2 pfam12796
Ankyrin repeats (3 copies);
274-335 1.72e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.10  E-value: 1.72e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116325987  274 MHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLeeLQKYDIDDENE 335
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL--LEHADVNLKDN 60
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 269-298 2.24e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 2.24e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 116325987   269 NGSTPMHKAAGQGHIECLQWLIKMGADSNI 298
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 56-186 2.31e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 43.21  E-value: 2.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  56 ADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQ-----------DDR---GCTPLHLAATHGHSFTLQIMLRSG 121
Cdd:cd22194  132 AEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNAHakgvffnpkykHEGfyfGETPLALAACTNQPEIVQLLMEKE 211

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116325987 122 VDP-SVTDKREWRPVH-----------YAAFHGRLGCLQLLVKWGCSIEDVDYNGNL-PVHLAAMEGHLHCFKFLVSR 186
Cdd:cd22194  212 STDiTSQDSRGNTVLHalvtvaedsktQNDFVKRMYDMILLKSENKNLETIRNNEGLtPLQLAAKMGKAEILKYILSR 289
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 97-126 2.16e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 2.16e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 116325987    97 RGCTPLHLAATHGHSFTLQIMLRSGVDPSV 126
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
30-236 1.06e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.90  E-value: 1.06e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  30 IHDAVRAGDVKqlseivCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHG 109
Cdd:COG0666   91 LHAAARNGDLE------IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 110 HSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMss 189
Cdd:COG0666  165 NLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG-- 242

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 116325987 190 ATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETL 236
Cdd:COG0666  243 ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-269 2.12e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 112.74  E-value: 2.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  50 WLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDK 129
Cdd:COG0666   72 LLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDN 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 130 REWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATqvlkAFNDNGENVLDLAQ 209
Cdd:COG0666  152 DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN----AKDNDGKTALDLAA 227

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 210 RFFKQNILQFIQgaEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADN 269
Cdd:COG0666  228 ENGNLEIVKLLL--EAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
51-340 6.82e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 111.20  E-value: 6.82e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKR 130
Cdd:COG0666   40 LLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKD 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 131 EWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRmssatqvlkafndngenvldlaqr 210
Cdd:COG0666  120 GETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA------------------------ 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 211 ffkqnilqfiqGAEYEGKDLEDQETLafpgHVAAFKGDLGMLKKLVEDGViNINERADNGSTPMHKAAGQGHIECLQWLI 290
Cdd:COG0666  176 -----------GADVNARDNDGETPL----HLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLL 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 116325987 291 KMGADSNITNKAGERPSDVAKRFAHLAAVKLLEELQKYDIDDENEIDEND 340
Cdd:COG0666  240 EAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
66-337 3.24e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 109.27  E-value: 3.24e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  66 WTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLG 145
Cdd:COG0666   22 ALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLE 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 146 CLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVsrmssatqvlkafnDNGENVldlaqrffkqNIlqfiqgaey 225
Cdd:COG0666  102 IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL--------------EAGADV----------NA--------- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 226 egKDlEDQETlafPGHVAAFKGDLGMLKKLVEDGViNINERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGER 305
Cdd:COG0666  149 --QD-NDGNT---PLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKT 221

                        250       260       270
                 ....*....|....*....|....*....|..
gi 116325987 306 PSDVAKRFAHLAAVKLLEELQKYDIDDENEID 337
Cdd:COG0666  222 ALDLAAENGNLEIVKLLLEAGADLNAKDKDGL 253
Ank_2 pfam12796
Ankyrin repeats (3 copies);
70-161 5.81e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.46  E-value: 5.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987   70 HIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLrSGVDPSVTDKReWRPVHYAAFHGRLGCLQL 149
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKDNG-RTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 116325987  150 LVKWGCSIEDVD 161
Cdd:pfam12796  80 LLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
30-128 1.28e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 1.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987   30 IHDAVRAGDVKqlseivCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALImNGANLTAQDDrGCTPLHLAATHG 109
Cdd:pfam12796   1 LHLAAKNGNLE------LVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKDN-GRTALHYAARSG 72

                          90
                  ....*....|....*....
gi 116325987  110 HSFTLQIMLRSGVDPSVTD 128
Cdd:pfam12796  73 HLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
102-186 2.37e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.22  E-value: 2.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  102 LHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKwgCSIEDVDYNGNLPVHLAAMEGHLHCFK 181
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE--HADVNLKDNGRTALHYAARSGHLEIVK 78


                  ....*
gi 116325987  182 FLVSR 186
Cdd:pfam12796  79 LLLEK 83
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 32-363 6.60e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 72.69  E-value: 6.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  32 DAVRAGDVKqlseIVCLhwLLWHGADITHVTTRG----WTASHIAA--------IRGQDACV-----------QALIMNG 88
Cdd:PHA02874  41 DAIRSGDAK----IVEL--FIKHGADINHINTKIphplLTAIKIGAhdiiklliDNGVDTSIlpipciekdmiKTILDCG 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  89 ANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPV 168
Cdd:PHA02874 115 IDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 169 HLAAMEGHLHCFKFLVsrmssatqvlkafnDNGENVLDLAQRFFKqnilqfiqgaeyegkdledqetlafPGHVAAFKgD 248
Cdd:PHA02874 195 HNAAEYGDYACIKLLI--------------DHGNHIMNKCKNGFT-------------------------PLHNAIIH-N 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 249 LGMLKKLVEDGVININERadNGSTPMHKAAGQG-HIECLQWLIKMGADSNITNKAGERPSDVAKRF-----------AHL 316
Cdd:PHA02874 235 RSAIELLINNASINDQDI--DGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKYinkdpvikdiiANA 312

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 116325987 317 AAVKLLEELQKYDIDDENEIDENDV-KYFIRHGVEGSTDAKDDLCLSD 363
Cdd:PHA02874 313 VLIKEADKLKDSDFLEHIEIKDNKEfSDFIKECNEEIEDMKKTKCGCD 360
PHA03095 PHA03095
ankyrin-like protein; Provisional
 14-198 6.71e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 69.67  E-value: 6.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  14 RETANPCSRKKVHFGSIHDAVRAGDVkqlsEIVCLHWLLWHGADITHVTTRGWTASHIAA--IRGQDACVQALIMNGANL 91
Cdd:PHA03095 140 RKGADVNALDLYGMTPLAVLLKSRNA----NVELLRLLIDAGADVYAVDDRFRSLLHHHLqsFKPRARIVRELIRAGCDP 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  92 TAQDDRGCTPLHLAATHGHSFTLQI--MLRSGVDPSVTDKREWRPVHYAA-FHGRLGCLQLLvKWGCSIEDVDYNGNLPV 168
Cdd:PHA03095 216 AATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAvFNNPRACRRLI-ALGADINAVSSDGNTPL 294

                        170       180       190
                 ....*....|....*....|....*....|
gi 116325987 169 HLAAMEGHLHCFKFLVSRMSSATQVLKAFN 198
Cdd:PHA03095 295 SLMVRNNNGRAVRAALAKNPSAETVAATLN 324
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 30-211 8.76e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 69.22  E-value: 8.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  30 IHDAVRAGDVKQLSEivclhwLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHG 109
Cdd:PHA02874 128 LHYAIKKGDLESIKM------LFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYG 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 110 HSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRlGCLQLLVKwGCSIEDVDYNGNLPVHLAAmegHLHCFKFLVSRMSS 189
Cdd:PHA02874 202 DYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR-SAIELLIN-NASINDQDIDGSTPLHHAI---NPPCDIDIIDILLY 276

                        170       180
                 ....*....|....*....|..
gi 116325987 190 ATQVLKAFNDNGENVLDLAQRF 211
Cdd:PHA02874 277 HKADISIKDNKGENPIDTAFKY 298
PHA03095 PHA03095
ankyrin-like protein; Provisional
 39-306 1.23e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.90  E-value: 1.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  39 VKQLSEIVCLhwLLWHGADITHVTTRGWTASHIAAIRGQDA-CVQALIMNGANLTAQDDRGCTPLH--LAATHGHSFTLQ 115
Cdd:PHA03095  59 SEKVKDIVRL--LLEAGADVNAPERCGFTPLHLYLYNATTLdVIKLLIKAGADVNAKDKVGRTPLHvyLSGFNINPKVIR 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 116 IMLRSGVDPSVTDKREWRPVH-YAAFHG-RLGCLQLLVKWGCSIEDVDYNGNLPVHlaameghlhcfKFLVSRMSSAtqv 193
Cdd:PHA03095 137 LLLRKGADVNALDLYGMTPLAvLLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLH-----------HHLQSFKPRA--- 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 194 lkafndngenvldlaqRFFKQNIlqfIQGAEYEGKDLEDQETLafpgHVAAFKGDLGMLK--KLVEDGVInINERADNGS 271
Cdd:PHA03095 203 ----------------RIVRELI---RAGCDPAATDMLGNTPL----HSMATGSSCKRSLvlPLLIAGIS-INARNRYGQ 258

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 116325987 272 TPMHKAAGQGHIECLQWLIKMGADSNITNKAGERP 306
Cdd:PHA03095 259 TPLHYAAVFNNPRACRRLIALGADINAVSSDGNTP 293
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 84-322 1.96e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 65.07  E-value: 1.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  84 LIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHG-RLGC----LQLLVKWGCSIE 158
Cdd:PHA03100  21 IIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKyNLTDvkeiVKLLLEYGANVN 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 159 DVDYNGNLPVHLAAME--GHLHCFKFLVSRMSSATQVlkafNDNGENVLDLaqrFFKQNilqfiqgaeyegkdledqetl 236
Cdd:PHA03100 101 APDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIK----NSDGENLLHL---YLESN--------------------- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 237 afpghvaafKGDLGMLKKLVEDGV---------------ININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNK 301
Cdd:PHA03100 153 ---------KIDLKILKLLIDKGVdinaknrvnyllsygVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNK 223

                        250       260
                 ....*....|....*....|.
gi 116325987 302 AGERPSDVAKRFAHLAAVKLL 322
Cdd:PHA03100 224 YGDTPLHIAILNNNKEIFKLL 244
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 105-330 4.88e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 64.50  E-value: 4.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 105 AATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFL- 183
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILy 611

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 184 -VSRMSSAtqvlkafndngenvldlaqrffkqnilqfiqgaeYEGKDLedqetLAFpghvAAFKGDLGMLKKLVEDGvIN 262
Cdd:PLN03192 612 hFASISDP----------------------------------HAAGDL-----LCT----AAKRNDLTAMKELLKQG-LN 647

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116325987 263 INERADNGSTPMHKAAGQGHIECLQWLIKMGADsnitnkagerpSDVAKRFAHLAAVKLLEELQKYDI 330
Cdd:PLN03192 648 VDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD-----------VDKANTDDDFSPTELRELLQKREL 704
Ank_2 pfam12796
Ankyrin repeats (3 copies);
169-300 8.56e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.20  E-value: 8.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  169 HLAAMEGHLHCFKFLVSRMSSATQVlkafNDNGENVLdlaqrffkqnilqfiqgaeyegkdledqetlafpgHVAAFKGD 248
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQ----DKNGRTAL-----------------------------------HLAAKNGH 42

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 116325987  249 LGMLKKLVEDGVININeraDNGSTPMHKAAGQGHIECLQWLIKMGADSNITN 300
Cdd:pfam12796  43 LEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
241-322 9.44e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.82  E-value: 9.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  241 HVAAFKGDLGMLKKLVEDGViNINERADNGSTPMHKAAGQGHIECLQWLIKmGADSNITNKaGERPSDVAKRFAHLAAVK 320
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78


                  ..
gi 116325987  321 LL 322
Cdd:pfam12796  79 LL 80
Ank_4 pfam13637
Ankyrin repeats (many copies);
131-184 3.95e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.97  E-value: 3.95e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 116325987  131 EWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLV 184
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 44-186 1.15e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 59.68  E-value: 1.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  44 EIVCLhwLLWHGADITHVTTRGWTASHIAAIR--GQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH------SFTLQ 115
Cdd:PHA03100  87 EIVKL--LLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidlkilKLLID 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 116 ------------IMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFL 183
Cdd:PHA03100 165 kgvdinaknrvnYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244


                 ...
gi 116325987 184 VSR 186
Cdd:PHA03100 245 LNN 247
Ank_4 pfam13637
Ankyrin repeats (many copies);
241-290 1.97e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.05  E-value: 1.97e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 116325987  241 HVAAFKGDLGMLKKLVEDGViNINERADNGSTPMHKAAGQGHIECLQWLI 290
Cdd:pfam13637   6 HAAAASGHLELLRLLLEKGA-DINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
100-151 7.47e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.51  E-value: 7.47e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 116325987  100 TPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLV 151
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 70-167 5.71e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.52  E-value: 5.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  70 HIAAiRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 149
Cdd:PTZ00322  88 QLAA-SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166

                         90
                 ....*....|....*...
gi 116325987 150 LVkwGCSIEDVDYNGNLP 167
Cdd:PTZ00322 167 LS--RHSQCHFELGANAK 182
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 30-171 6.30e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.68  E-value: 6.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  30 IHDAVRAGDVKQLseivcLHWLLWHGADITHVTTRGWTASHIAAIRGQDA-CVQALIMNGANLTAQDDRGCTPLHLAAT- 107
Cdd:PHA02876 277 LHHASQAPSLSRL-----VPKLLERGADVNAKNIKGETPLYLMAKNGYDTeNIRTLIMLGADVNAADRLYITPLHQASTl 351

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 116325987 108 HGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLA 171
Cdd:PHA02876 352 DRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFA 415
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 56-200 7.50e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 54.49  E-value: 7.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  56 ADIThvTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIM--LRSGVDPSVTDKRewr 133
Cdd:PLN03192 551 PDIG--DSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILyhFASISDPHAAGDL--- 625

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 116325987 134 pVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVsrMSSATqVLKAFNDN 200
Cdd:PLN03192 626 -LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI--MNGAD-VDKANTDD 688
Ank_5 pfam13857
Ankyrin repeats (many copies);
255-310 7.53e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.50  E-value: 7.53e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 116325987  255 LVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVA 310
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
65-110 9.00e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 9.00e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 116325987   65 GWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGN 46
Ank_4 pfam13637
Ankyrin repeats (many copies);
270-322 2.22e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.27  E-value: 2.22e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 116325987  270 GSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 90-298 1.04e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 50.37  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  90 NLTAQDdrGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDY-NGNLPV 168
Cdd:PHA02875  29 NFEIYD--GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYkDGMTPL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 169 HLAAMEGHLHCFKFLVSRMSSAtqvlKAFNDNGENVLDLAQRFFKQNILQFIQGAEyEGKDLEDQETLAfPGHVAAFKGD 248
Cdd:PHA02875 107 HLATILKKLDIMKLLIARGADP----DIPNTDKFSPLHLAVMMGDIKGIELLIDHK-ACLDIEDCCGCT-PLIIAMAKGD 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 116325987 249 LGMLKKLVEDGViNINERADNGS-TPMHKAAGQGHIECLQWLIKMGADSNI 298
Cdd:PHA02875 181 IAICKMLLDSGA-NIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADCNI 230
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 81-171 2.33e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.49  E-value: 2.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  81 VQALIMNGANLTAQD-DRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIED 159
Cdd:PHA02878 150 TKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                         90
                 ....*....|..
gi 116325987 160 VDYNGNLPVHLA 171
Cdd:PHA02878 230 RDKCGNTPLHIS 241
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 122-322 3.74e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.81  E-value: 3.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 122 VDPSVTdkrewrPVHYAAFHGRLGCLQLLVKWGCSIEDVdyNGNLPVHLaameghlhcfkfLVSRMSSATQVLKAFNDNG 201
Cdd:PHA02874  32 VDETTT------PLIDAIRSGDAKIVELFIKHGADINHI--NTKIPHPL------------LTAIKIGAHDIIKLLIDNG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 202 ENVLDLAQRFFKQNILQFI--QGAEYEGKDLEDQETLafpgHVAAFKGDLGMLKKLVEDGViNINERADNGSTPMHKAAG 279
Cdd:PHA02874  92 VDTSILPIPCIEKDMIKTIldCGIDVNIKDAELKTFL----HYAIKKGDLESIKMLFEYGA-DVNIEDDNGCYPIHIAIK 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 116325987 280 QGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
Cdd:PHA02874 167 HNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLL 209
Ank_5 pfam13857
Ankyrin repeats (many copies);
56-105 4.92e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.49  E-value: 4.92e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 116325987   56 ADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLA 105
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 252-357 5.11e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.12  E-value: 5.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 252 LKKLVEDGViNINERADNGSTPMHKAAGQ--GHIECLQWLIKMGADSNITNKAGERPSDVAKRFAH--LAAVKLLEElQK 327
Cdd:PHA03100  89 VKLLLEYGA-NVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLID-KG 166

                         90       100       110
                 ....*....|....*....|....*....|
gi 116325987 328 YDIDDENEIDendvkYFIRHGVegSTDAKD 357
Cdd:PHA03100 167 VDINAKNRVN-----YLLSYGV--PINIKD 189
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 51-161 5.68e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.12  E-value: 5.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  51 LLWHGADITHVTTRGWTASHIAAIRGQ----------------DAC--VQALIMNGANLTAQDDRGCTPLHLAATHGHSF 112
Cdd:PHA03100 127 LLDNGANVNIKNSDGENLLHLYLESNKidlkilkllidkgvdiNAKnrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPE 206

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 116325987 113 TLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVD 161
Cdd:PHA03100 207 FVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTII 255
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 115-306 6.08e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.14  E-value: 6.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 115 QIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQ-- 192
Cdd:PHA02876 162 EMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKnd 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 193 --VLKAF-NDNGENVLDLAQRFFKQNILQFIQGAeyegkdledqetlafPGHVAAFKGDLG-MLKKLVEDGvININERAD 268
Cdd:PHA02876 242 lsLLKAIrNEDLETSLLLYDAGFSVNSIDDCKNT---------------PLHHASQAPSLSrLVPKLLERG-ADVNAKNI 305

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 116325987 269 NGSTPMHKAAGQGH-IECLQWLIKMGADSNITNKAGERP 306
Cdd:PHA02876 306 KGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITP 344
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 90-175 1.28e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.20  E-value: 1.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  90 NLTAQDDRGCTPLH--------LAAThGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVD 161
Cdd:PTZ00322  67 NLTTEEVIDPVVAHmltvelcqLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLD 145

                         90
                 ....*....|....
gi 116325987 162 YNGNLPVHLAAMEG 175
Cdd:PTZ00322 146 KDGKTPLELAEENG 159
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 70-225 1.35e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.91  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  70 HIAAIRGQDACVQALIMNGanlTAQDD----RGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLG 145
Cdd:PHA02875  73 HDAVEEGDVKAVEELLDLG---KFADDvfykDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 146 CLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFL---------VSRMSSATQVLKAFNDNGENVLDL-AQRFFKQN 215
Cdd:PHA02875 150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLldsganidyFGKNGCVAALCYAIENNKIDIVRLfIKRGADCN 229

                        170
                 ....*....|
gi 116325987 216 ILQFIQGAEY 225
Cdd:PHA02875 230 IMFMIEGEEC 239
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 43-171 2.48e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.03  E-value: 2.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  43 SEIVCLhwLLWHGADITHVTT-RGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSG 121
Cdd:PHA02878 147 AEITKL--LLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENG 224

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 116325987 122 VDPSVTDKREWRPVHYAAfhGRL---GCLQLLVKWGCSIEDVDYNGNL-PVHLA 171
Cdd:PHA02878 225 ASTDARDKCGNTPLHISV--GYCkdyDILKLLLEHGVDVNAKSYILGLtALHSS 276
Ank_4 pfam13637
Ankyrin repeats (many copies);
30-85 3.00e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 3.00e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 116325987   30 IHDAVRAGDVKqlseivCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALI 85
Cdd:pfam13637   5 LHAAAASGHLE------LLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 269-301 3.60e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 3.60e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 116325987  269 NGSTPMHKAAGQ-GHIECLQWLIKMGADSNITNK 301
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
Ank_5 pfam13857
Ankyrin repeats (many copies);
89-138 6.08e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.41  E-value: 6.08e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 116325987   89 ANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYA 138
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 30-157 6.19e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.98  E-value: 6.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  30 IHDAVRAGDVKQLSEIV----------------------------CLHWLLWHGADITHVTTRGWTASHIAAIRGQDACV 81
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLdlgkfaddvfykdgmtplhlatilkkldIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI 151

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116325987  82 QALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKR-EWRPVHYAAFHGRLGCLQLLVKWG--CSI 157
Cdd:PHA02875 152 ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGadCNI 230
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 241-322 9.68e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.50  E-value: 9.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 241 HVAAfKGDLGMLKKLVEDGViNINERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVK 320
Cdd:PTZ00322  88 QLAA-SGDAVGARILLTGGA-DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165


                 ..
gi 116325987 321 LL 322
Cdd:PTZ00322 166 LL 167
PHA02798 PHA02798
ankyrin-like protein; Provisional
 81-304 9.83e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 44.44  E-value: 9.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  81 VQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQI---MLRSGVDPSVTDKREWRpvhyaafhgrlgCLQLLVKWGCSI 157
Cdd:PHA02798  92 VKILIENGADINKKNSDGETPLYCLLSNGYINNLEIllfMIENGADTTLLDKDGFT------------MLQVYLQSNHHI 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 158 E------------DVDYNGNlpvhlaaMEGH--LHC-FKFLVSRMSSatQVLKAFNDNGEnVLDLAQRFFKQNILQFIQG 222
Cdd:PHA02798 160 DieiiklllekgvDINTHNN-------KEKYdtLHCyFKYNIDRIDA--DILKLFVDNGF-IINKENKSHKKKFMEYLNS 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 223 AEYEGKDLeDQETLAFpghvaAFKgdlgmlkklvedgVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKA 302
Cdd:PHA02798 230 LLYDNKRF-KKNILDF-----IFS-------------YIDINQVDELGFNPLYYSVSHNNRKIFEYLLQLGGDINIITEL 290


                 ..
gi 116325987 303 GE 304
Cdd:PHA02798 291 GN 292
Ank_2 pfam12796
Ankyrin repeats (3 copies);
274-335 1.72e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.10  E-value: 1.72e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116325987  274 MHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLeeLQKYDIDDENE 335
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL--LEHADVNLKDN 60
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 269-298 2.24e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 2.24e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 116325987   269 NGSTPMHKAAGQGHIECLQWLIKMGADSNI 298
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 56-186 2.31e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 43.21  E-value: 2.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  56 ADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQ-----------DDR---GCTPLHLAATHGHSFTLQIMLRSG 121
Cdd:cd22194  132 AEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNAHakgvffnpkykHEGfyfGETPLALAACTNQPEIVQLLMEKE 211

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116325987 122 VDP-SVTDKREWRPVH-----------YAAFHGRLGCLQLLVKWGCSIEDVDYNGNL-PVHLAAMEGHLHCFKFLVSR 186
Cdd:cd22194  212 STDiTSQDSRGNTVLHalvtvaedsktQNDFVKRMYDMILLKSENKNLETIRNNEGLtPLQLAAKMGKAEILKYILSR 289
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 269-298 2.54e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.01  E-value: 2.54e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 116325987  269 NGSTPMHKAAGQGHIECLQWLIKMGADSNI 298
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02946 PHA02946
ankyin-like protein; Provisional
 73-185 2.68e-04

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 42.73  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  73 AIRGQDA-CVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGR--LGCLQL 149
Cdd:PHA02946  46 GIKGLDErFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINL 125

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 116325987 150 LVKWGCSIED-VDYNGNLPVhLAAMEGHLHCFKFLVS 185
Cdd:PHA02946 126 LVQYGAKINNsVDEEGCGPL-LACTDPSERVFKKIMS 161
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 97-129 1.26e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.11  E-value: 1.26e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 116325987   97 RGCTPLHLAATH-GHSFTLQIMLRSGVDPSVTDK 129
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 82-295 1.37e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.82  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  82 QALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQ------------- 148
Cdd:PHA02876 162 EMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKaiidnrsninknd 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 149 ----------------LLVKWGCSIEDVDYNGNLPVHLAAMEGHLhcfKFLVSRMSSATQVLKAFNDNGENVLDLAQR-- 210
Cdd:PHA02876 242 lsllkairnedletslLLYDAGFSVNSIDDCKNTPLHHASQAPSL---SRLVPKLLERGADVNAKNIKGETPLYLMAKng 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 211 FFKQNILQFIQgaeyEGKDLEDQETLAF-PGHVAA-FKGDLGMLKKLVEDGViNINERADNGSTPMHKAAGQGHIECLQW 288
Cdd:PHA02876 319 YDTENIRTLIM----LGADVNAADRLYItPLHQAStLDRNKDIVITLLELGA-NVNARDYCDKTPIHYAAVRNNVVIINT 393


                 ....*..
gi 116325987 289 LIKMGAD 295
Cdd:PHA02876 394 LLDYGAD 400
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 51-119 1.68e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.65  E-value: 1.68e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116325987  51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLR 119
Cdd:PTZ00322 101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 97-126 2.16e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 2.16e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 116325987    97 RGCTPLHLAATHGHSFTLQIMLRSGVDPSV 126
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 56-186 2.56e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 39.78  E-value: 2.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  56 ADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQ---------DDRGC-----TPLHLAATHGHSFTLQIMLRSG 121
Cdd:cd22193   67 AEYTDEYYEGQTALHIAIERRQGDIVALLVENGADVHAHakgrffqpkYQGEGfyfgeLPLSLAACTNQPDIVQYLLENE 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 122 ---VDPSVTDKREWRPVHY-----------AAFHGRL--GCLQLLVKW--GCSIEDVDYNGNL-PVHLAAMEGHLHCFKF 182
Cdd:cd22193  147 hqpADIEAQDSRGNTVLHAlvtvadntkenTKFVTRMydMILIRGAKLcpTVELEEIRNNDGLtPLQLAAKMGKIEILKY 226


                 ....
gi 116325987 183 LVSR 186
Cdd:cd22193  227 ILQR 230
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 64-96 3.12e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 3.12e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 116325987   64 RGWTASHIAAIR-GQDACVQALIMNGANLTAQDD 96
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 134-322 3.65e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.48  E-value: 3.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 134 PVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVS-----RMSSATQVLK-AFNDNGENVLD- 206
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRsinkcSVFYTLVAIKdAFNNRNVEIFKi 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 207 -LAQRFFKQNILQFIQGAEYEGKDLEDQEtlafpghvaafkgdlgMLKKLVEDGV-ININERaDNGSTPMHKAAGQGHIE 284
Cdd:PHA02878 120 iLTNRYKNIQTIDLVYIDKKSKDDIIEAE----------------ITKLLLSYGAdINMKDR-HKGNTALHYATENKDQR 182

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 116325987 285 CLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
Cdd:PHA02878 183 LTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHIL 220
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 33-174 5.87e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.84  E-value: 5.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987  33 AVRAGDVKQLSEIvclhwLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANL-----TAQDDRGCTPLHLAAT 107
Cdd:cd22192   24 AAKENDVQAIKKL-----LKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELvnepmTSDLYQGETALHIAVV 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325987 108 HGHSFTLQIMLRSGVD---PSVTDK--REWR---------PVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAM 173
Cdd:cd22192   99 NQNLNLVRELIARGADvvsPRATGTffRPGPknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVL 178


                 .
gi 116325987 174 E 174
Cdd:cd22192  179 Q 179
Ank_5 pfam13857
Ankyrin repeats (many copies);
122-171 8.12e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 34.24  E-value: 8.12e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 116325987  122 VDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLA 171
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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