NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|187608797|ref|NP_898914|]
View 

tonsoku-like protein [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
523-635 4.66e-29

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.52  E-value: 4.66e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  523 NRRNDMGETLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDpggQGCDGITPL 602
Cdd:COG0666   114 NARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNA---RDNDGETPL 190

                          90       100       110
                  ....*....|....*....|....*....|...
gi 187608797  603 HDALNCGHFEVAELLIERGASVTLRTRKGLSPL 635
Cdd:COG0666   191 HLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 1023-1327 5.36e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 88.31  E-value: 5.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1023 VLHAMDHQSSSPSFSACSLALCQAQLTPLLR---ALKLHTALRELRLAGNRLGDACATELLATLGTTPNLVLLDLSSNHL 1099
Cdd:COG5238   169 AAISMAKALQNNSVETVYLGCNQIGDEGIEElaeALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQI 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1100 GQEGLRQLVEgssgqaALQN---LEELDLSMNPLGDGCGQALASLLracpmlstlrlqacgfsssfflshqaalggafQD 1176
Cdd:COG5238   249 GDEGVIALAE------ALKNnttVETLYLSGNQIGAEGAIALAKAL--------------------------------QG 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1177 AVHLKTLSLSYNLLGAP---ALARVLQTlpACTLKRLDLSSvaASKSNSGIIePVIKYLtKEGCALAHLTLSANCLGDKA 1253
Cdd:COG5238   291 NTTLTSLDLSVNRIGDEgaiALAEGLQG--NKTLHTLNLAY--NGIGAQGAI-ALAKAL-QENTTLHSLDLSDNQIGDEG 364

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 187608797 1254 VRELSRCLPCCPSLTSLDLSANpEVSCASLEELLSALQERSqgLSFLGLSGcsiqGPLNSDLWDKIFVQLQELQ 1327
Cdd:COG5238   365 AIALAKYLEGNTTLRELNLGKN-NIGKQGAEALIDALQTNR--LHTLILDG----NLIGAEAQQRLEQLLERIK 431
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
197-450 4.03e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.86  E-value: 4.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  197 LYEDLFRARYNLGAIHWRGGQHSQAMRCLEgarecaRAMKMRFMESECCVLVSQVLQDLGDFLAAKRALKKAYRLGSQKP 276
Cdd:COG0457     3 LDPDDAEAYNNLGLAYRRLGRYEEAIEDYE------KALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  277 NQRvtvcqslkYVLAVIQLQQ-QLEEAEgNDLQGAMAI-------CEQLGDLFSKAGDFPKAAEAYQKQLHLaellnrpD 348
Cdd:COG0457    77 EAL--------NNLGLALQALgRYEEAL-EDYDKALELdpddaeaLYNLGLALLELGRYDEAIEAYERALEL-------D 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  349 LELAVIHVSLATTLGDMKDHRKAVHHYEEELRLRKGNALEEAKTWFNIALSREEAGDAYELLAPCFQKAFCCAQQAQRFQ 428
Cdd:COG0457   141 PDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALA 220

                         250       260
                  ....*....|....*....|..
gi 187608797  429 LQRQILQHLYTVQLKLQPQEAR 450
Cdd:COG0457   221 ELLLLALALLLALRLAALALYQ 242
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 46-271 4.21e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 48.07  E-value: 4.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797   46 ALEEHQQELHLLESVQDTLGCAVAHRKIGERLAEMENYSAALKHQHLYLDLAGSLSNHTELQRAWATIGRTHLDIYDHCQ 125
Cdd:COG3914     4 AALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLEL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  126 sRDSLLQAQAAFEKSLAIVDEKLEgmltqreLSEMRTRLYLNLGLTCESLQQTALCNNYFKKSIFLAEqnhlyeDLFRAR 205
Cdd:COG3914    84 -AALLLQALGRYEEALALYRRALA-------LNPDNAEALFNLGNLLLALGRLEEALAALRRALALNP------DFAEAY 149

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187608797  206 YNLGAIHWRGGQHSQAMRCLEgarecaRAMKMRFMESECCVLVSQVLQDLGDFLAAKRALKKAYRL 271
Cdd:COG3914   150 LNLGEALRRLGRLEEAIAALR------RALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALEL 209
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 663-922 6.42e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 6.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  663 RLQMASSGQASRSSPALQTIPSNHLFDPETSPPSspcPEPSSYTPRPPEASPAPAKVFLEETVSAVSRPRKTRH--RPTS 740
Cdd:PHA03247 2599 RAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPS---PAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRlgRAAQ 2675

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  741 SSSssedednpSPCRPSQKRLRHTTQQ--GEVKIPDPPKSREtatsSACRAAYQAAIRGVGSAQSRRLVPSLPRGSEEVP 818
Cdd:PHA03247 2676 ASS--------PPQRPRRRAARPTVGSltSLADPPPPPPTPE----PAPHALVSATPLPPGPAAARQASPALPAAPAPPA 2743

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  819 APKTALIPEEEylagewlevdtplTRSGRPSTSVSDYERCPARPRTRVKQSRLTSLDGWCARTQAGDGSLNAEPAENPSV 898
Cdd:PHA03247 2744 VPAGPATPGGP-------------ARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA 2810

                         250       260
                  ....*....|....*....|....
gi 187608797  899 prTSGPNKENYAAGQPLLLVQPPP 922
Cdd:PHA03247 2811 --VLAPAAALPPAASPAGPLPPPT 2832
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
523-635 4.66e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.52  E-value: 4.66e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  523 NRRNDMGETLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDpggQGCDGITPL 602
Cdd:COG0666   114 NARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNA---RDNDGETPL 190

                          90       100       110
                  ....*....|....*....|....*....|...
gi 187608797  603 HDALNCGHFEVAELLIERGASVTLRTRKGLSPL 635
Cdd:COG0666   191 HLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223
Ank_2 pfam12796
Ankyrin repeats (3 copies);
533-627 4.53e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 91.72  E-value: 4.53e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797   533 LHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDpggqgCDGITPLHDALNCGHFE 612
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK-----DNGRTALHYAARSGHLE 75

                           90
                   ....*....|....*
gi 187608797   613 VAELLIERGASVTLR 627
Cdd:pfam12796   76 IVKLLLEKGADINVK 90
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 1023-1327 5.36e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 88.31  E-value: 5.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1023 VLHAMDHQSSSPSFSACSLALCQAQLTPLLR---ALKLHTALRELRLAGNRLGDACATELLATLGTTPNLVLLDLSSNHL 1099
Cdd:COG5238   169 AAISMAKALQNNSVETVYLGCNQIGDEGIEElaeALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQI 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1100 GQEGLRQLVEgssgqaALQN---LEELDLSMNPLGDGCGQALASLLracpmlstlrlqacgfsssfflshqaalggafQD 1176
Cdd:COG5238   249 GDEGVIALAE------ALKNnttVETLYLSGNQIGAEGAIALAKAL--------------------------------QG 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1177 AVHLKTLSLSYNLLGAP---ALARVLQTlpACTLKRLDLSSvaASKSNSGIIePVIKYLtKEGCALAHLTLSANCLGDKA 1253
Cdd:COG5238   291 NTTLTSLDLSVNRIGDEgaiALAEGLQG--NKTLHTLNLAY--NGIGAQGAI-ALAKAL-QENTTLHSLDLSDNQIGDEG 364

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 187608797 1254 VRELSRCLPCCPSLTSLDLSANpEVSCASLEELLSALQERSqgLSFLGLSGcsiqGPLNSDLWDKIFVQLQELQ 1327
Cdd:COG5238   365 AIALAKYLEGNTTLRELNLGKN-NIGKQGAEALIDALQTNR--LHTLILDG----NLIGAEAQQRLEQLLERIK 431
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1055-1345 2.88e-17

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 84.33  E-value: 2.88e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1055 LKLHTALRELRLAGNRLGDACATELLATLGTTPNLVLLDLSSNHLGqEGLRQLVEGSSGQAALQNLEELDLSMNPLGDGC 1134
Cdd:cd00116    19 LPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETG-RIPRGLQSLLQGLTKGCGLQELDLSDNALGPDG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1135 GQALASLLRAcPMLSTLRLQACGFSSSfflsHQAALGGAFQD-AVHLKTLSLSYNLLGAPALARVLQTLPA-CTLKRLDL 1212
Cdd:cd00116    98 CGVLESLLRS-SSLQELKLNNNGLGDR----GLRLLAKGLKDlPPALEKLVLGRNRLEGASCEALAKALRAnRDLKELNL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1213 SsvaasksNSGIIEPVIKYLT---KEGCALAHLTLSANCLGDKAVRELSRCLPCCPSLTSLDLSANPeVSCASLEELLSA 1289
Cdd:cd00116   173 A-------NNGIGDAGIRALAeglKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNN-LTDAGAAALASA 244

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 187608797 1290 LQERSQGLSFLGLSGCSIQGPLNSDLWDKI--FVQLQELQLCTKDLSTKDRDSVCQRL 1345
Cdd:cd00116   245 LLSPNISLLTLSLSCNDITDDGAKDLAEVLaeKESLLELDLRGNKFGEEGAQLLAESL 302
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 544-667 1.19e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 65.46  E-value: 1.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  544 RVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAavdDPGGQGCDGITPLHDALNCGHFEVAELLIERGAS 623
Cdd:PHA03100  174 RVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGA---NPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 187608797  624 VtlrtrkglsplETLQQWVkLYFRDLDLETRQKAATMEKRLQMA 667
Cdd:PHA03100  251 I-----------KTIIETL-LYFKDKDLNTITKIKMLKKSIMYM 282
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
197-450 4.03e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.86  E-value: 4.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  197 LYEDLFRARYNLGAIHWRGGQHSQAMRCLEgarecaRAMKMRFMESECCVLVSQVLQDLGDFLAAKRALKKAYRLGSQKP 276
Cdd:COG0457     3 LDPDDAEAYNNLGLAYRRLGRYEEAIEDYE------KALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  277 NQRvtvcqslkYVLAVIQLQQ-QLEEAEgNDLQGAMAI-------CEQLGDLFSKAGDFPKAAEAYQKQLHLaellnrpD 348
Cdd:COG0457    77 EAL--------NNLGLALQALgRYEEAL-EDYDKALELdpddaeaLYNLGLALLELGRYDEAIEAYERALEL-------D 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  349 LELAVIHVSLATTLGDMKDHRKAVHHYEEELRLRKGNALEEAKTWFNIALSREEAGDAYELLAPCFQKAFCCAQQAQRFQ 428
Cdd:COG0457   141 PDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALA 220

                         250       260
                  ....*....|....*....|..
gi 187608797  429 LQRQILQHLYTVQLKLQPQEAR 450
Cdd:COG0457   221 ELLLLALALLLALRLAALALYQ 242
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 562-590 4.97e-07

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 47.20  E-value: 4.97e-07
                            10        20
                    ....*....|....*....|....*....
gi 187608797    562 GWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1061-1275 2.75e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 2.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1061 LRELRLAGNRLgdacATELLATLGTTPNLVLLDLSSNHLGQEglrqLVEG--SSGqaalqNLEELDLSMNPLGDGCGQAL 1138
Cdd:PLN00113  334 LQVLQLWSNKF----SGEIPKNLGKHNNLTVLDLSTNNLTGE----IPEGlcSSG-----NLFKLILFSNSLEGEIPKSL 400

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1139 AsllrACPMLSTLRLQACGFSSS-----------FFL-----SHQAALGGAFQDAVHLKTLSLSYNLL--GAPALARvlq 1200
Cdd:PLN00113  401 G----ACRSLRRVRLQDNSFSGElpseftklplvYFLdisnnNLQGRINSRKWDMPSLQMLSLARNKFfgGLPDSFG--- 473

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 187608797 1201 tlpACTLKRLDLSsvaaSKSNSGIIEPVIKYLTKegcaLAHLTLSANCLGDKAVRELSRclpcCPSLTSLDLSAN 1275
Cdd:PLN00113  474 ---SKRLENLDLS----RNQFSGAVPRKLGSLSE----LMQLKLSENKLSGEIPDELSS----CKKLVSLDLSHN 533
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 525-638 3.99e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.09  E-value: 3.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  525 RNDMGETLLHRACIEGQ-------LRRVQDLVKQghPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDP------ 591
Cdd:cd22192    47 RGALGETALHVAALYDNleaavvlMEAAPELVNE--PMTSDLYQGETALHIAVVNQNLNLVRELIARGADVVSPratgtf 124

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 187608797  592 --GGQGCD---GITPLHDALNCGHFEVAELLIERGASVTLRTRKGLSPLETL 638
Cdd:cd22192   125 frPGPKNLiyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHIL 176
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 46-271 4.21e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 48.07  E-value: 4.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797   46 ALEEHQQELHLLESVQDTLGCAVAHRKIGERLAEMENYSAALKHQHLYLDLAGSLSNHTELQRAWATIGRTHLDIYDHCQ 125
Cdd:COG3914     4 AALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLEL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  126 sRDSLLQAQAAFEKSLAIVDEKLEgmltqreLSEMRTRLYLNLGLTCESLQQTALCNNYFKKSIFLAEqnhlyeDLFRAR 205
Cdd:COG3914    84 -AALLLQALGRYEEALALYRRALA-------LNPDNAEALFNLGNLLLALGRLEEALAALRRALALNP------DFAEAY 149

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187608797  206 YNLGAIHWRGGQHSQAMRCLEgarecaRAMKMRFMESECCVLVSQVLQDLGDFLAAKRALKKAYRL 271
Cdd:COG3914   150 LNLGEALRRLGRLEEAIAALR------RALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALEL 209
TPR_12 pfam13424
Tetratricopeptide repeat;
316-383 2.38e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 40.83  E-value: 2.38e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 187608797   316 QLGDLFSKAGDFPKAAEAYQKQLHLAELLNRPD-LELAVIHVSLATTLGDMKDHRKAVHHYEEELRLRK 383
Cdd:pfam13424    8 NLAAVLRRLGRYDEALELLEKALEIARRLLGPDhPLTATTLLNLGRLYLELGRYEEALELLERALALAE 76
PHA03247 PHA03247
large tegument protein UL36; Provisional
 663-922 6.42e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 6.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  663 RLQMASSGQASRSSPALQTIPSNHLFDPETSPPSspcPEPSSYTPRPPEASPAPAKVFLEETVSAVSRPRKTRH--RPTS 740
Cdd:PHA03247 2599 RAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPS---PAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRlgRAAQ 2675

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  741 SSSssedednpSPCRPSQKRLRHTTQQ--GEVKIPDPPKSREtatsSACRAAYQAAIRGVGSAQSRRLVPSLPRGSEEVP 818
Cdd:PHA03247 2676 ASS--------PPQRPRRRAARPTVGSltSLADPPPPPPTPE----PAPHALVSATPLPPGPAAARQASPALPAAPAPPA 2743

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  819 APKTALIPEEEylagewlevdtplTRSGRPSTSVSDYERCPARPRTRVKQSRLTSLDGWCARTQAGDGSLNAEPAENPSV 898
Cdd:PHA03247 2744 VPAGPATPGGP-------------ARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA 2810

                         250       260
                  ....*....|....*....|....
gi 187608797  899 prTSGPNKENYAAGQPLLLVQPPP 922
Cdd:PHA03247 2811 --VLAPAAALPPAASPAGPLPPPT 2832
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
523-635 4.66e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.52  E-value: 4.66e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  523 NRRNDMGETLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDpggQGCDGITPL 602
Cdd:COG0666   114 NARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNA---RDNDGETPL 190

                          90       100       110
                  ....*....|....*....|....*....|...
gi 187608797  603 HDALNCGHFEVAELLIERGASVTLRTRKGLSPL 635
Cdd:COG0666   191 HLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
523-635 5.02e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 115.44  E-value: 5.02e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  523 NRRNDMGETLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDpggQGCDGITPL 602
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNA---QDNDGNTPL 157

                          90       100       110
                  ....*....|....*....|....*....|...
gi 187608797  603 HDALNCGHFEVAELLIERGASVTLRTRKGLSPL 635
Cdd:COG0666   158 HLAAANGNLEIVKLLLEAGADVNARDNDGETPL 190
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
523-659 3.90e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 104.27  E-value: 3.90e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  523 NRRNDMGETLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAavdDPGGQGCDGITPL 602
Cdd:COG0666   147 NAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA---DVNAKDNDGKTAL 223

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 187608797  603 HDALNCGHFEVAELLIERGASVTLRTRKGLSPLETLQQWVKLYFRDLDLETRQKAAT 659
Cdd:COG0666   224 DLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAA 280
Ank_2 pfam12796
Ankyrin repeats (3 copies);
533-627 4.53e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 91.72  E-value: 4.53e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797   533 LHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDpggqgCDGITPLHDALNCGHFE 612
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK-----DNGRTALHYAARSGHLE 75

                           90
                   ....*....|....*
gi 187608797   613 VAELLIERGASVTLR 627
Cdd:pfam12796   76 IVKLLLEKGADINVK 90
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
518-635 3.21e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 89.63  E-value: 3.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  518 KVNKWNRRNDMGETLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGqgcD 597
Cdd:COG0666    43 ALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDK---D 119

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 187608797  598 GITPLHDALNCGHFEVAELLIERGASVTLRTRKGLSPL 635
Cdd:COG0666   120 GETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL 157
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 1023-1327 5.36e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 88.31  E-value: 5.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1023 VLHAMDHQSSSPSFSACSLALCQAQLTPLLR---ALKLHTALRELRLAGNRLGDACATELLATLGTTPNLVLLDLSSNHL 1099
Cdd:COG5238   169 AAISMAKALQNNSVETVYLGCNQIGDEGIEElaeALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQI 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1100 GQEGLRQLVEgssgqaALQN---LEELDLSMNPLGDGCGQALASLLracpmlstlrlqacgfsssfflshqaalggafQD 1176
Cdd:COG5238   249 GDEGVIALAE------ALKNnttVETLYLSGNQIGAEGAIALAKAL--------------------------------QG 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1177 AVHLKTLSLSYNLLGAP---ALARVLQTlpACTLKRLDLSSvaASKSNSGIIePVIKYLtKEGCALAHLTLSANCLGDKA 1253
Cdd:COG5238   291 NTTLTSLDLSVNRIGDEgaiALAEGLQG--NKTLHTLNLAY--NGIGAQGAI-ALAKAL-QENTTLHSLDLSDNQIGDEG 364

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 187608797 1254 VRELSRCLPCCPSLTSLDLSANpEVSCASLEELLSALQERSqgLSFLGLSGcsiqGPLNSDLWDKIFVQLQELQ 1327
Cdd:COG5238   365 AIALAKYLEGNTTLRELNLGKN-NIGKQGAEALIDALQTNR--LHTLILDG----NLIGAEAQQRLEQLLERIK 431
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1055-1345 2.88e-17

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 84.33  E-value: 2.88e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1055 LKLHTALRELRLAGNRLGDACATELLATLGTTPNLVLLDLSSNHLGqEGLRQLVEGSSGQAALQNLEELDLSMNPLGDGC 1134
Cdd:cd00116    19 LPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETG-RIPRGLQSLLQGLTKGCGLQELDLSDNALGPDG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1135 GQALASLLRAcPMLSTLRLQACGFSSSfflsHQAALGGAFQD-AVHLKTLSLSYNLLGAPALARVLQTLPA-CTLKRLDL 1212
Cdd:cd00116    98 CGVLESLLRS-SSLQELKLNNNGLGDR----GLRLLAKGLKDlPPALEKLVLGRNRLEGASCEALAKALRAnRDLKELNL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1213 SsvaasksNSGIIEPVIKYLT---KEGCALAHLTLSANCLGDKAVRELSRCLPCCPSLTSLDLSANPeVSCASLEELLSA 1289
Cdd:cd00116   173 A-------NNGIGDAGIRALAeglKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNN-LTDAGAAALASA 244

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 187608797 1290 LQERSQGLSFLGLSGCSIQGPLNSDLWDKI--FVQLQELQLCTKDLSTKDRDSVCQRL 1345
Cdd:cd00116   245 LLSPNISLLTLSLSCNDITDDGAKDLAEVLaeKESLLELDLRGNKFGEEGAQLLAESL 302
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 980-1307 3.67e-13

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 73.29  E-value: 3.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  980 DPIPDVLQSNDEVLAEVTSWDLPPLKDRYRRAC-----LSLGQGEHQQV---LHAMDHQSSSPSFSACSLALCQAQLTPL 1051
Cdd:COG5238    91 VVDWEGAEEVSPVALAETATAVATPPPDLRRIMaktleDSLILYLALPRrinLIQVLKDPLGGNAVHLLGLAARLGLLAA 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1052 LRALK--LHTALRELRLAGNRLGDACATELLATLGTTPNLVLLDLSSNHLGQEGLRQLVEGSSGQAALQNLeelDLSMNP 1129
Cdd:COG5238   171 ISMAKalQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTL---DLSNNQ 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1130 LGDGCGQALASLLRACPMLSTLRLqacgfsSSFFLSHQ--AALGGAFQDAVHLKTLSLSYNLLGAP---ALARVLQTlpA 1204
Cdd:COG5238   248 IGDEGVIALAEALKNNTTVETLYL------SGNQIGAEgaIALAKALQGNTTLTSLDLSVNRIGDEgaiALAEGLQG--N 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1205 CTLKRLDLSSvaasksnsgiiepvikyltkegcalahltlsaNCLGDKAVRELSRCLPCCPSLTSLDLSANpEVSCASLE 1284
Cdd:COG5238   320 KTLHTLNLAY--------------------------------NGIGAQGAIALAKALQENTTLHSLDLSDN-QIGDEGAI 366

                         330       340
                  ....*....|....*....|...
gi 187608797 1285 ELLSALQERSQgLSFLGLSGCSI 1307
Cdd:COG5238   367 ALAKYLEGNTT-LRELNLGKNNI 388
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1045-1337 1.22e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 1.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1045 QAQLTPLLRALKLHTALRELRLAGNRlgdacatellaTLGTTPNLVLLDLSSNHLGQ--EGLRQLvegssgqaalQNLEE 1122
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGNE-----------ELSNLTNLESLDLSGNQLTDlpEELANL----------TNLKE 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1123 LDLSMNPLGDgcgqaLASLLRACPMLSTLRLQACGFSSsfflshqaaLGGAFQDAVHLKTLSLSYNLLGapALARVLQTL 1202
Cdd:COG4886   141 LDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTD---------LPEELGNLTNLKELDLSNNQIT--DLPEPLGNL 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1203 PActLKRLDLssvaaskSNSGI--IEPVIKYLTKegcaLAHLTLSANCLGDkaVRELSRclpcCPSLTSLDLSAN----- 1275
Cdd:COG4886   205 TN--LEELDL-------SGNQLtdLPEPLANLTN----LETLDLSNNQLTD--LPELGN----LTNLEELDLSNNqltdl 265

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 187608797 1276 -PEVSCASLEEL-LSALQERSQGLSFLGLSGCSIQGPLNSDLWDKIFVQLQELQLCTKDLSTKD 1337
Cdd:COG4886   266 pPLANLTNLKTLdLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1041-1293 3.50e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 3.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1041 LALCQAQLTPLLRALKLHTALRELRLAGNRLgdacaTELLATLGTTPNLVLLDLSSNhlgqeglrQLVEGSSGQAALQNL 1120
Cdd:COG4886   118 LDLSGNQLTDLPEELANLTNLKELDLSNNQL-----TDLPEPLGNLTNLKSLDLSNN--------QLTDLPEELGNLTNL 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1121 EELDLSMNPLGDgcgqaLASLLRACPMLSTLRLQACGFSSsfflshqaaLGGAFQDAVHLKTLSLSYNLLGA-PALARvl 1199
Cdd:COG4886   185 KELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD---------LPEPLANLTNLETLDLSNNQLTDlPELGN-- 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1200 qtLPActLKRLDLSsvaaskSN--SGIiePVIKYLTKegcaLAHLTLSANCLGDKAVRELSRCLPCCPSLTSLDLSANPE 1277
Cdd:COG4886   249 --LTN--LEELDLS------NNqlTDL--PPLANLTN----LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLE 312

                         250
                  ....*....|....*.
gi 187608797 1278 VSCASLEELLSALQER 1293
Cdd:COG4886   313 LLILLLLLTTLLLLLL 328
Ank_2 pfam12796
Ankyrin repeats (3 copies);
523-586 4.18e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.51  E-value: 4.18e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 187608797   523 NRRNDMGETLLHRACIEGQLRRVQDLVKQGHpLNPRDYcGWTPLHEACNYGHLEIVRFLLDHGA 586
Cdd:pfam12796   24 NLQDKNGRTALHLAAKNGHLEIVKLLLEHAD-VNLKDN-GRTALHYAARSGHLEIVKLLLEKGA 85
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 544-667 1.19e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 65.46  E-value: 1.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  544 RVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAavdDPGGQGCDGITPLHDALNCGHFEVAELLIERGAS 623
Cdd:PHA03100  174 RVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGA---NPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 187608797  624 VtlrtrkglsplETLQQWVkLYFRDLDLETRQKAATMEKRLQMA 667
Cdd:PHA03100  251 I-----------KTIIETL-LYFKDKDLNTITKIKMLKKSIMYM 282
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1048-1213 1.23e-10

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 64.30  E-value: 1.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1048 LTPLLRALKLHTALRELRLAGNRLGDACATELLATLGTTPNLVLLDLSSNHLGQEGLRQLVEGSsgqAALQNLEELDLSM 1127
Cdd:cd00116   154 CEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETL---ASLKSLEVLNLGD 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1128 NPLGDGCGQALASLLRAcpmlstlrlqacgfsssffLSHQaalggafqdavhLKTLSLSYNLLGAPALARVLQTLPA-CT 1206
Cdd:cd00116   231 NNLTDAGAAALASALLS-------------------PNIS------------LLTLSLSCNDITDDGAKDLAEVLAEkES 279


                  ....*..
gi 187608797 1207 LKRLDLS 1213
Cdd:cd00116   280 LLELDLR 286
Ank_4 pfam13637
Ankyrin repeats (many copies);
531-582 1.64e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 57.67  E-value: 1.64e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 187608797   531 TLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLL 582
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 531-653 2.70e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 64.28  E-value: 2.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  531 TLLHRACiEGQLRRVQDLVKQGHPLNPRDYCGWTPLH-EACNYGHLEIVRFLLDHGAAVDDPGGQGcdgITPLHDALN-- 607
Cdd:PHA03095   53 LYLHYSS-EKVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVG---RTPLHVYLSgf 128

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 187608797  608 CGHFEVAELLIERGASVTLRTRKGLSPLETLqqwvkLYFRDLDLET 653
Cdd:PHA03095  129 NINPKVIRLLLRKGADVNALDLYGMTPLAVL-----LKSRNANVEL 169
Ank_4 pfam13637
Ankyrin repeats (many copies);
562-618 6.52e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.74  E-value: 6.52e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 187608797   562 GWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCdgiTPLHDALNCGHFEVAELLI 618
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGE---TALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 521-637 1.79e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.52  E-value: 1.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  521 KWNRRNDMGETLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGA--AVDDPGGQgcdg 598
Cdd:PHA02874  116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAyaNVKDNNGE---- 191

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 187608797  599 iTPLHDALNCGHFEVAELLIERGASVTLRTRKGLSPLET 637
Cdd:PHA02874  192 -SPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHN 229
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
197-450 4.03e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.86  E-value: 4.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  197 LYEDLFRARYNLGAIHWRGGQHSQAMRCLEgarecaRAMKMRFMESECCVLVSQVLQDLGDFLAAKRALKKAYRLGSQKP 276
Cdd:COG0457     3 LDPDDAEAYNNLGLAYRRLGRYEEAIEDYE------KALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  277 NQRvtvcqslkYVLAVIQLQQ-QLEEAEgNDLQGAMAI-------CEQLGDLFSKAGDFPKAAEAYQKQLHLaellnrpD 348
Cdd:COG0457    77 EAL--------NNLGLALQALgRYEEAL-EDYDKALELdpddaeaLYNLGLALLELGRYDEAIEAYERALEL-------D 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  349 LELAVIHVSLATTLGDMKDHRKAVHHYEEELRLRKGNALEEAKTWFNIALSREEAGDAYELLAPCFQKAFCCAQQAQRFQ 428
Cdd:COG0457   141 PDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALA 220

                         250       260
                  ....*....|....*....|..
gi 187608797  429 LQRQILQHLYTVQLKLQPQEAR 450
Cdd:COG0457   221 ELLLLALALLLALRLAALALYQ 242
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 531-628 4.25e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.31  E-value: 4.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  531 TLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCdgITPLHDALNCGH 610
Cdd:PHA02875  137 SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGC--VAALCYAIENNK 214

                          90
                  ....*....|....*...
gi 187608797  611 FEVAELLIERGASVTLRT 628
Cdd:PHA02875  215 IDIVRLFIKRGADCNIMF 232
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 523-636 9.70e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 56.21  E-value: 9.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  523 NRRNDMGETLLHRACIE--GQLRRVQDLVKQGHPLNPRDYCGWTPLHEA--CNYGHLEIVRFLLDHGAAVDdpggqGCD- 597
Cdd:PHA03100  100 NAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYleSNKIDLKILKLLIDKGVDIN-----AKNr 174

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 187608797  598 -----------------GITPLHDALNCGHFEVAELLIERGASVTLRTRKGLSPLE 636
Cdd:PHA03100  175 vnyllsygvpinikdvyGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLH 230
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 526-617 1.06e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 56.45  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  526 NDMGETLLHRACIE-------GQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAavdDPGGQGCDG 598
Cdd:PTZ00322   72 EVIDPVVAHMLTVElcqlaasGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGA---DPTLLDKDG 148

                          90
                  ....*....|....*....
gi 187608797  599 ITPLHDALNCGHFEVAELL 617
Cdd:PTZ00322  149 KTPLELAEENGFREVVQLL 167
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 530-635 1.33e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 55.77  E-value: 1.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  530 ETLLHRACIEGQLRRVQDLVKQGHPLNPRDYC-GWTPLHEACNYGHLEIVRFLLDHGAavdDPGGQGCDGITPLHDALNC 608
Cdd:PHA02875   69 ESELHDAVEEGDVKAVEELLDLGKFADDVFYKdGMTPLHLATILKKLDIMKLLIARGA---DPDIPNTDKFSPLHLAVMM 145

                          90       100
                  ....*....|....*....|....*..
gi 187608797  609 GHFEVAELLIERGASVTLRTRKGLSPL 635
Cdd:PHA02875  146 GDIKGIELLIDHKACLDIEDCCGCTPL 172
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 523-642 3.55e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.20  E-value: 3.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  523 NRRNDMGETLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQG------- 595
Cdd:PHA02874  151 NIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGftplhna 230

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  596 ---------------------CDGITPLHDALN--CGhFEVAELLIERGASVTLRTRKGLSPLETLQQWV 642
Cdd:PHA02874  231 iihnrsaiellinnasindqdIDGSTPLHHAINppCD-IDIIDILLYHKADISIKDNKGENPIDTAFKYI 299
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 561-589 3.64e-07

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 47.64  E-value: 3.64e-07
                           10        20
                   ....*....|....*....|....*....
gi 187608797   561 CGWTPLHEACNYGHLEIVRFLLDHGAAVD 589
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 562-590 4.97e-07

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 47.20  E-value: 4.97e-07
                            10        20
                    ....*....|....*....|....*....
gi 187608797    562 GWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 527-635 8.84e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 53.35  E-value: 8.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  527 DMGETLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDdpgGQGCDGITPLHDAL 606
Cdd:PHA02878  166 HKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTD---ARDKCGNTPLHISV 242

                          90       100       110
                  ....*....|....*....|....*....|.
gi 187608797  607 N-CGHFEVAELLIERGASVTLR-TRKGLSPL 635
Cdd:PHA02878  243 GyCKDYDILKLLLEHGVDVNAKsYILGLTAL 273
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 562-589 1.19e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 46.13  E-value: 1.19e-06
                           10        20
                   ....*....|....*....|....*....
gi 187608797   562 GWTPLHEAC-NYGHLEIVRFLLDHGAAVD 589
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVN 30
PHA03095 PHA03095
ankyrin-like protein; Provisional
 542-637 1.99e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.95  E-value: 1.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  542 LRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGH---LEIVRFLLDHGAAVDDPGGQGCdgiTPLHD-ALNCGHFEVAELL 617
Cdd:PHA03095   27 VEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGF---TPLHLyLYNATTLDVIKLL 103

                          90       100
                  ....*....|....*....|
gi 187608797  618 IERGASVTLRTRKGLSPLET 637
Cdd:PHA03095  104 IKAGADVNAKDKVGRTPLHV 123
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
165-411 2.54e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.39  E-value: 2.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  165 YLNLGLTCESLQQTALCNNYFKKSIflaeqnHLYEDLFRARYNLGAIHWRGGQHSQAMRCLEgarecaRAMKMRFMESEC 244
Cdd:COG0457    11 YNNLGLAYRRLGRYEEAIEDYEKAL------ELDPDDAEALYNLGLAYLRLGRYEEALADYE------QALELDPDDAEA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  245 CVLVSQVLQDLGDFLAAKRALKKAYRLGSQKP---NQRVTVCQSL-KYVLAVIQLQQQLEEAEGNDlqgamAICEQLGDL 320
Cdd:COG0457    79 LNNLGLALQALGRYEEALEDYDKALELDPDDAealYNLGLALLELgRYDEAIEAYERALELDPDDA-----DALYNLGIA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  321 FSKAGDFPKAAEAYQKQLHLAELLNRPDLELAVIHVSLATTLGDMKDHRKAVHHYEEELRLRKGNALEEAKTWFNIALSR 400
Cdd:COG0457   154 LEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLAL 233

                         250
                  ....*....|.
gi 187608797  401 EEAGDAYELLA 411
Cdd:COG0457   234 RLAALALYQYR 244
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 514-635 3.34e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.12  E-value: 3.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  514 VGRRKVNKWNRRNDMGETLLHRACIEGQLrrVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGG 593
Cdd:PHA02874   78 IGAHDIIKLLIDNGVDTSILPIPCIEKDM--IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDD 155

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 187608797  594 QGCdgiTPLHDALNCGHFEVAELLIERGASVTLRTRKGLSPL 635
Cdd:PHA02874  156 NGC---YPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194
Ank_5 pfam13857
Ankyrin repeats (many copies);
581-636 8.35e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.26  E-value: 8.35e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 187608797   581 LLDHGAAvdDPGGQGCDGITPLHDALNCGHFEVAELLIERGASVTLRTRKGLSPLE 636
Cdd:pfam13857    1 LLEHGPI--DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 578-636 2.16e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.13  E-value: 2.16e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 187608797  578 VRFLLDHGAavdDPGGQGCDGITPLHDALNCGHFEVAELLIERGASVTLRTRKGLSPLE 636
Cdd:PTZ00322   98 ARILLTGGA---DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLE 153
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1061-1275 2.75e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 2.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1061 LRELRLAGNRLgdacATELLATLGTTPNLVLLDLSSNHLGQEglrqLVEG--SSGqaalqNLEELDLSMNPLGDGCGQAL 1138
Cdd:PLN00113  334 LQVLQLWSNKF----SGEIPKNLGKHNNLTVLDLSTNNLTGE----IPEGlcSSG-----NLFKLILFSNSLEGEIPKSL 400

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1139 AsllrACPMLSTLRLQACGFSSS-----------FFL-----SHQAALGGAFQDAVHLKTLSLSYNLL--GAPALARvlq 1200
Cdd:PLN00113  401 G----ACRSLRRVRLQDNSFSGElpseftklplvYFLdisnnNLQGRINSRKWDMPSLQMLSLARNKFfgGLPDSFG--- 473

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 187608797 1201 tlpACTLKRLDLSsvaaSKSNSGIIEPVIKYLTKegcaLAHLTLSANCLGDKAVRELSRclpcCPSLTSLDLSAN 1275
Cdd:PLN00113  474 ---SKRLENLDLS----RNQFSGAVPRKLGSLSE----LMQLKLSENKLSGEIPDELSS----CKKLVSLDLSHN 533
Ank_5 pfam13857
Ankyrin repeats (many copies);
548-603 2.88e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 2.88e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 187608797   548 LVKQGHP-LNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCdgiTPLH 603
Cdd:pfam13857    1 LLEHGPIdLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGL---TALD 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 525-638 3.99e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.09  E-value: 3.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  525 RNDMGETLLHRACIEGQ-------LRRVQDLVKQghPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDP------ 591
Cdd:cd22192    47 RGALGETALHVAALYDNleaavvlMEAAPELVNE--PMTSDLYQGETALHIAVVNQNLNLVRELIARGADVVSPratgtf 124

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 187608797  592 --GGQGCD---GITPLHDALNCGHFEVAELLIERGASVTLRTRKGLSPLETL 638
Cdd:cd22192   125 frPGPKNLiyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHIL 176
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 46-271 4.21e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 48.07  E-value: 4.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797   46 ALEEHQQELHLLESVQDTLGCAVAHRKIGERLAEMENYSAALKHQHLYLDLAGSLSNHTELQRAWATIGRTHLDIYDHCQ 125
Cdd:COG3914     4 AALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLEL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  126 sRDSLLQAQAAFEKSLAIVDEKLEgmltqreLSEMRTRLYLNLGLTCESLQQTALCNNYFKKSIFLAEqnhlyeDLFRAR 205
Cdd:COG3914    84 -AALLLQALGRYEEALALYRRALA-------LNPDNAEALFNLGNLLLALGRLEEALAALRRALALNP------DFAEAY 149

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187608797  206 YNLGAIHWRGGQHSQAMRCLEgarecaRAMKMRFMESECCVLVSQVLQDLGDFLAAKRALKKAYRL 271
Cdd:COG3914   150 LNLGEALRRLGRLEEAIAALR------RALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALEL 209
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 523-635 4.89e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 47.75  E-value: 4.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  523 NRRNDMGETLLHRAcieGQLRRVQD----LVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQ-Gcd 597
Cdd:PHA02876  335 NAADRLYITPLHQA---STLDRNKDivitLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKiG-- 409

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 187608797  598 giTPLHDALnCGH--FEVAELLIERGASVTLRTRKGLSPL 635
Cdd:PHA02876  410 --TALHFAL-CGTnpYMSVKTLIDRGANVNSKNKDLSTPL 446
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 291-417 5.13e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 44.23  E-value: 5.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  291 AVIQLQQQLEeAEGNDLQGAMaiceQLGDLFSKAGDFPKAAEAYQKQLHLAEllnrpdlELAVIHVSLATTLGDMKDHRK 370
Cdd:COG4235     2 AIARLRQALA-ANPNDAEGWL----LLGRAYLRLGRYDEALAAYEKALRLDP-------DNADALLDLAEALLAAGDTEE 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 187608797  371 AVHHYEEELRLRKGNaleeAKTWFNIALSREEAGDaYELLAPCFQKA 417
Cdd:COG4235    70 AEELLERALALDPDN----PEALYLLGLAAFQQGD-YAEAIAAWQKL 111
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 529-631 5.27e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 47.29  E-value: 5.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  529 GETLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCdgiTPLHDALNC 608
Cdd:PHA02875  102 GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGC---TPLIIAMAK 178

                          90       100
                  ....*....|....*....|...
gi 187608797  609 GHFEVAELLIERGASVTLRTRKG 631
Cdd:PHA02875  179 GDIAICKMLLDSGANIDYFGKNG 201
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1059-1154 6.98e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 6.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1059 TALRELRLAGNRLGDACATEL----LATLGTTpnLVLLDLSSNHLgqEGLRQLvegssgqAALQNLEELDLSMNPLGDgc 1134
Cdd:cd21340    90 TNLEELHIENQRLPPGEKLTFdprsLAALSNS--LRVLNISGNNI--DSLEPL-------APLRNLEQLDASNNQISD-- 156

                          90       100
                  ....*....|....*....|
gi 187608797 1135 GQALASLLRACPMLSTLRLQ 1154
Cdd:cd21340   157 LEELLDLLSSWPSLRELDLT 176
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 597-629 8.16e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.12  E-value: 8.16e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 187608797   597 DGITPLHDA-LNCGHFEVAELLIERGASVTLRTR 629
Cdd:pfam00023    1 DGNTPLHLAaGRRGNLEIVKLLLSKGADVNARDK 34
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 294-452 8.99e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.91  E-value: 8.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  294 QLQQQLEEAEGNDLQGAMAICEQLGDLFSKAGDFPKAAEAYQKQLHLAEllnrpdlELAVIHVSLATTLGDMKDHRKAVH 373
Cdd:COG3914    61 ALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNP-------DNAEALFNLGNLLLALGRLEEALA 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  374 HYEEELRLRKGNALeeakTWFNIALSREEAGDayellapcFQKAFCCAQQAQRFQLQR-QILQHLYTVQLKL-QPQEARD 451
Cdd:COG3914   134 ALRRALALNPDFAE----AYLNLGEALRRLGR--------LEEAIAALRRALELDPDNaEALNNLGNALQDLgRLEEAIA 201


                  .
gi 187608797  452 T 452
Cdd:COG3914   202 A 202
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
25-234 1.44e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.00  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797   25 EEAAYCHQLGELLASHGRFKDALEEHQQELHLLESVqdtlgcAVAHRKIGERLAEMENYSAALKHQHLYLDLagslsnHT 104
Cdd:COG0457     6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDD------AEALYNLGLAYLRLGRYEEALADYEQALEL------DP 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  105 ELQRAWATIGRTHLDIYDHcqsrdslLQAQAAFEKSLAIVDEKLEgmltqrelsemrtrLYLNLGLTCESLQQTALCNNY 184
Cdd:COG0457    74 DDAEALNNLGLALQALGRY-------EEALEDYDKALELDPDDAE--------------ALYNLGLALLELGRYDEAIEA 132

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 187608797  185 FKKSIFLAeqnhlyEDLFRARYNLGAIHWRGGQHSQAMRCLEGARECARA 234
Cdd:COG0457   133 YERALELD------PDDADALYNLGIALEKLGRYEEALELLEKLEAAALA 176
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 530-624 1.93e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.77  E-value: 1.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  530 ETLLHRACIEGQLRRVQDLVKQGH-PLNPRDYCGWTPLHEACNYGHLEIVRFLLDhgAA---VDDP-GGQGCDGITPLHD 604
Cdd:cd22192    18 ESPLLLAAKENDVQAIKKLLKCPScDLFQRGALGETALHVAALYDNLEAAVVLME--AApelVNEPmTSDLYQGETALHI 95

                          90       100
                  ....*....|....*....|
gi 187608797  605 ALNCGHFEVAELLIERGASV 624
Cdd:cd22192    96 AVVNQNLNLVRELIARGADV 115
TPR_12 pfam13424
Tetratricopeptide repeat;
316-383 2.38e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 40.83  E-value: 2.38e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 187608797   316 QLGDLFSKAGDFPKAAEAYQKQLHLAELLNRPD-LELAVIHVSLATTLGDMKDHRKAVHHYEEELRLRK 383
Cdd:pfam13424    8 NLAAVLRRLGRYDEALELLEKALEIARRLLGPDhPLTATTLLNLGRLYLELGRYEEALELLERALALAE 76
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 597-626 2.42e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 2.42e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 187608797    597 DGITPLHDALNCGHFEVAELLIERGASVTL 626
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 529-639 3.51e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 45.24  E-value: 3.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  529 GETLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRfLLDHGAAVDDPGGQG---C--------- 596
Cdd:PLN03192  558 GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFR-ILYHFASISDPHAAGdllCtaakrndlt 636

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187608797  597 -----------------DGITPLHDALNCGHFEVAELLIERGASVT-LRTRKGLSPLETLQ 639
Cdd:PLN03192  637 amkellkqglnvdsedhQGATALQVAMAEDHVDMVRLLIMNGADVDkANTDDDFSPTELRE 697
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 523-590 3.81e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.66  E-value: 3.81e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 187608797  523 NRRNDMGETLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
Cdd:PHA03100  186 NIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1204-1286 4.25e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 4.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797 1204 ACTLKRLDLSsvaasKSNSGIIEPvIKYLTkegcALAHLTLSANCLGDkaVRELSRCLPCCPSLTSLDLSANP------- 1276
Cdd:cd21340   119 SNSLRVLNIS-----GNNIDSLEP-LAPLR----NLEQLDASNNQISD--LEELLDLLSSWPSLRELDLTGNPvckkpky 186

                          90
                  ....*....|....
gi 187608797 1277 -E---VSCASLEEL 1286
Cdd:cd21340   187 rDkiiLASKSLEVL 200
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 529-635 5.47e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 44.23  E-value: 5.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  529 GETLLHRACIEGQLRRVQDLVKQG-HPLNPRD-------------YCGWTPLHEACNYGHLEIVRFLLDHGAavdDPGGQ 594
Cdd:cd22192    89 GETALHIAVVNQNLNLVRELIARGaDVVSPRAtgtffrpgpknliYYGEHPLSFAACVGNEEIVRLLIEHGA---DIRAQ 165

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 187608797  595 GCDGITPLH-------DALNCGHFEVAELLIERGASVTL---RTRKGLSPL 635
Cdd:cd22192   166 DSLGNTVLHilvlqpnKTFACQMYDLILSYDKEDDLQPLdlvPNNQGLTPF 216
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 548-635 7.93e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 43.50  E-value: 7.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  548 LVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAavdDPGGQGCDGITPLHDALNCGH-----FEVAELLIERGA 622
Cdd:PHA03100   21 IIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGA---DINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGA 97

                          90
                  ....*....|...
gi 187608797  623 SVTLRTRKGLSPL 635
Cdd:PHA03100   98 NVNAPDNNGITPL 110
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 539-653 2.03e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 42.36  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  539 EGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDpggQGCDGITPLHDALNCGHFEVAELLI 618
Cdd:PHA02876  155 QDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNI---IALDDLSVLECAVDSKNIDTIKAII 231

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 187608797  619 ERGASVtlrTRKGLSPLETLqqwvklyfRDLDLET 653
Cdd:PHA02876  232 DNRSNI---NKNDLSLLKAI--------RNEDLET 255
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 249-381 2.38e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 2.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  249 SQVLQDLGDFLAAKRALKKAYRLGSQKPnqrvtvcqSLKYVLAVIQLQQ-QLEEAEgNDLQGAMAIC-------EQLGDL 320
Cdd:COG4783    11 AQALLLAGDYDEAEALLEKALELDPDNP--------EAFALLGEILLQLgDLDEAI-VLLHEALELDpdepearLNLGLA 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187608797  321 FSKAGDFPKAAEAYQKQLHLAEllnrpdlELAVIHVSLATTLGDMKDHRKAVHHYEEELRL 381
Cdd:COG4783    82 LLKAGDYDEALALLEKALKLDP-------EHPEAYLRLARAYRALGRPDEAIAALEKALEL 135
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 32-339 2.51e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.25  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797   32 QLGELLASHGRFKDALEEHQQelhLLESVQDTlgcAVAHRKIGERLAEMENYSAALKhqhLYLDLAGSLSNHTELQRAWA 111
Cdd:COG2956    47 ALGNLYRRRGEYDRAIRIHQK---LLERDPDR---AEALLELAQDYLKAGLLDRAEE---LLEKLLELDPDDAEALRLLA 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  112 TIgrthldiydhcqsrdslLQAQAAFEKSLAIVdEKLEgmltqrELSEMRTRLYLNLGLTCESLQQTALCNNYFKKSIFL 191
Cdd:COG2956   118 EI-----------------YEQEGDWEKAIEVL-ERLL------KLGPENAHAYCELAELYLEQGDYDEAIEALEKALKL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  192 AEQNhlyedlFRARYNLGAIHWRGGQHSQAMRCLEgarecaramkmrfmeseccvlvsQVLQDLGDFLAAKRALKKAYRL 271
Cdd:COG2956   174 DPDC------ARALLLLAELYLEQGDYEEAIAALE-----------------------RALEQDPDYLPALPRLAELYEK 224

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 187608797  272 GSQKPNqrvtvcqslkyvlAVIQLQQQLEEAEGNDLQGAmaiceqLGDLFSKAGDFPKAAEAYQKQLH 339
Cdd:COG2956   225 LGDPEE-------------ALELLRKALELDPSDDLLLA------LADLLERKEGLEAALALLERQLR 273
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 156-382 3.48e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.87  E-value: 3.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  156 ELSEMRTRLYLNLGLTCESLQQTALCNNYFKKSIflaeqnHLYEDLFRARYNLGAIHWRGGQHSQAMRCLEgarecaRAM 235
Cdd:COG2956    70 ERDPDRAEALLELAQDYLKAGLLDRAEELLEKLL------ELDPDDAEALRLLAEIYEQEGDWEKAIEVLE------RLL 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  236 KMRFMESECCVLVSQVLQDLGDFLAAKRALKKAYRLgsqKPNqrvtvCQSLKYVLAVIQLQQQ--------LEEAEGNDL 307
Cdd:COG2956   138 KLGPENAHAYCELAELYLEQGDYDEAIEALEKALKL---DPD-----CARALLLLAELYLEQGdyeeaiaaLERALEQDP 209

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 187608797  308 QGAMAIcEQLGDLFSKAGDFPKAAEAYQKQLHLAellnrPDLELaviHVSLATTLGDMKDHRKAVHHYEEELRLR 382
Cdd:COG2956   210 DYLPAL-PRLAELYEKLGDPEEALELLRKALELD-----PSDDL---LLALADLLERKEGLEAALALLERQLRRH 275
YfgM COG2976
Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal ...
 247-336 3.99e-03

Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal transduction mechanisms];


Pssm-ID: 442215 [Multi-domain]  Cd Length: 207  Bit Score: 40.22  E-value: 3.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  247 LVSQVLQDLGDFLAAKRALKKAYRLGSQKPnqrvtvcqsLKYV----LAVIQLQQ--------QLEEAEGNDLQGAMAic 314
Cdd:COG2976    95 LLAKAAVDAGDLDKAAAQLQWVLDNAKDPA---------LKALarlrLARVLLAQkkydealaTLDAVKPEAFAALYA-- 163

                          90       100
                  ....*....|....*....|..
gi 187608797  315 EQLGDLFSKAGDFPKAAEAYQK 336
Cdd:COG2976   164 ELRGDILLAQGDKAEARAAYQK 185
PHA03247 PHA03247
large tegument protein UL36; Provisional
 663-922 6.42e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 6.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  663 RLQMASSGQASRSSPALQTIPSNHLFDPETSPPSspcPEPSSYTPRPPEASPAPAKVFLEETVSAVSRPRKTRH--RPTS 740
Cdd:PHA03247 2599 RAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPS---PAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRlgRAAQ 2675

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  741 SSSssedednpSPCRPSQKRLRHTTQQ--GEVKIPDPPKSREtatsSACRAAYQAAIRGVGSAQSRRLVPSLPRGSEEVP 818
Cdd:PHA03247 2676 ASS--------PPQRPRRRAARPTVGSltSLADPPPPPPTPE----PAPHALVSATPLPPGPAAARQASPALPAAPAPPA 2743

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187608797  819 APKTALIPEEEylagewlevdtplTRSGRPSTSVSDYERCPARPRTRVKQSRLTSLDGWCARTQAGDGSLNAEPAENPSV 898
Cdd:PHA03247 2744 VPAGPATPGGP-------------ARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA 2810

                         250       260
                  ....*....|....*....|....
gi 187608797  899 prTSGPNKENYAAGQPLLLVQPPP 922
Cdd:PHA03247 2811 --VLAPAAALPPAASPAGPLPPPT 2832
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH