|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
38-433 |
1.78e-163 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 464.72 E-value: 1.78e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 38 TGILLLGTCLLYCARVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVT 117
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 118 TPLLAHlgsGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSV 197
Cdd:cd17380 81 TPLLAY---SSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 198 FYFSGGLTLLWAYYVYRYLLnekdlvlalgflaqglpvtkpskvpwrqlfrkaSVWAAICSQLCSACSFFILLSWLPTFF 277
Cdd:cd17380 158 FYFFGLLGLLWALVWLIYLP---------------------------------PVWAIIVAHFCMNWGFYILLSWLPTYF 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 278 KETF-PNSKGWVFNVVPWMLAIPASLFSGFISDRLISQGYRVITVRKFMQVMGLGLSSIFALCLGHTTSFLKAMIFASAS 356
Cdd:cd17380 205 HEVLvPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCMSVA 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 125347351 357 IGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVFHLVAIISNLGLGTFLVFG 433
Cdd:cd17380 285 LGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
38-433 |
7.57e-112 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 334.59 E-value: 7.57e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 38 TGILLLGTCLLYCARVTMPVCTVAMSQ----------------------DFGWNKKEAGIVLSSFFWGYCLTQVVGGHLG 95
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNstathdnnntstdkdtlpveapEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 96 DRIGGEKVILLSASAWGFITVTTPLLAHlgsGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQ 175
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPLAAR---GGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 176 VGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRyllnekdLVLAlgflaqglpvtkpskvpwrqlfrkasVWAA 255
Cdd:cd17318 158 FGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFF-------LVLP--------------------------VWAI 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 256 ICSQLCSACSFFILLSWLPTFFKET--FPNSKGWVFNVVPWMLAIPASLFSGFISDRLISQG-YRVITVRKFMQVMGLGL 332
Cdd:cd17318 205 VVAHFGHNWGFYTLLTELPTYMSDVlhFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGiLSTTTVRKLFTSIGFLG 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 333 SSIFALCLGHTTS-FLKAMIFASASIGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLI---ETT 408
Cdd:cd17318 285 PGVFLIALGYLGSnATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAIVkndQTI 364
|
410 420
....*....|....*....|....*
gi 125347351 409 GSWTCVFHLVAIISNLGLGTFLVFG 433
Cdd:cd17318 365 GQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
43-433 |
1.78e-45 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 162.12 E-value: 1.78e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 43 LGTCLLYCARVTMPVCTVAM---------------SQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLS 107
Cdd:cd17382 6 LGFCISFGIRCNLGVAIVRMvnnftdayggkvivhKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 108 ASAWGFITVTTPLLAHLgsgHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSV 187
Cdd:cd17382 86 IFVTSTLNMLIPIAARV---HYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 188 LLDQCGWQSVFYFSGGLTLLWAyyvyryllnekdlvlaLGFLAQGLPVtkpskvpwrqlfrkasvWAAICSQLCSACSFF 267
Cdd:cd17382 163 LVQYVGWSSPFYVYGVFGIIWY----------------MFWMLVSMPV-----------------YAIIVANFCRSWTFY 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 268 ILLSWLPTFFKETF--PNSKGWVFNVVPWMLAIPASLFSGFISDRLISQGYRVIT-VRKFMQVMGLGLSSIFALCLGHTT 344
Cdd:cd17382 210 LLLISQPAYFKEVFgfDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTaVRKIFNCGGFGMEATFLLVVAFSH 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 345 SFLKAMIFASASIGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLI--ETTGSWTCVFHLVAIIS 422
Cdd:cd17382 290 SPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTkhKTREEWQYVFLIASLVH 369
|
410
....*....|.
gi 125347351 423 NLGLGTFLVFG 433
Cdd:cd17382 370 FFGVIFYAIFA 380
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
64-433 |
6.35e-44 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 158.40 E-value: 6.35e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 64 QDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLLAHLGSGHLAFLtfsRILTGLLQ 143
Cdd:cd17381 58 KKYDWDAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAV---RALEGLGE 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 144 GVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRyllnekdLV 223
Cdd:cd17381 135 GVTFPAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIW-------LV 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 224 LALgflaqglpvtkpskvpwrqlfrkasvWAAICSQLCSACSFFILLSWLPTFFKET--FPNSKGWVFNVVPWMLAIPAS 301
Cdd:cd17381 208 MPL--------------------------WAIVVAHFSYNWTFYTLLTLLPTYMKEIlrFDIQENGFLSALPYLGCWLFM 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 302 LFSGFISDRLIS-QGYRVITVRKFMQVMGLGLSSIFALCLGHT-TSFLKAMIFASASIGFQTFNHSGISVNIQDLAPSCA 379
Cdd:cd17381 262 ILSGQIADNLREkQNFSTVCVRKIFTLIGMIGPAVFLLAAGFTgCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYA 341
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 125347351 380 GFLFGVANTAGALAGVVGVCLSGYLIE--TTGSWTCVFHLVAIISNLGLGTFLVFG 433
Cdd:cd17381 342 GILLGITNTFATIPGMVGPVIAKSLTHnnTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
39-431 |
2.02e-43 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 155.81 E-value: 2.02e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 39 GILLLGTCLLYCARVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTT 118
Cdd:cd17319 6 PLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 119 PLLahlgSGHLAFLTFsRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVF 198
Cdd:cd17319 86 GFA----TSLTSLYVL-RFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 199 YFSGGLTLLWAYYVYRYLLNekdlvlalgflaqglpvtkpskvpwrqlfrkasVWAAICSQLCSACSFFILLSWLPTFFK 278
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYLRQ---------------------------------VWGLALGYFGINYALYGLLTWLPTYLK 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 279 ET--FPNSKGWVFNVVPWMLAIPASLFSGFISDRLISQgyrvitVRKFMQVMGLGLSSIFALCLGHTTSFLKAMIFASAS 356
Cdd:cd17319 208 QArgFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG------ARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLA 281
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 125347351 357 IGFQTFNHSGISVNIQDLAP-SCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVFHLVAIISNLGLGTFLV 431
Cdd:cd17319 282 GFGIGAASPVFWSLPADLLPgEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
39-437 |
4.35e-41 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 150.02 E-value: 4.35e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 39 GILLLGTCLLYCARVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTT 118
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 119 PLlahlgSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVF 198
Cdd:COG2271 93 GF-----ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 199 YFSGGLTLLWAYyvyryllnekdlvlalgflaqglpvtkpskvpwrqlfrkASVWAAICSQLCSACSFFILLSWLPTFFK 278
Cdd:COG2271 168 LILGLPGLLLAL---------------------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLV 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 279 ET--FPNSKGWVFNVVPWMLAIPASLFSGFISDRLISQGYRVITVrkfmqvmGLGLSSIFALCLGHTTSFLKAMIFASAS 356
Cdd:COG2271 209 EVrgLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAI-------GLLLAALALLLLALLPSPALAIALLFLA 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 357 IGFQTFNHSGISVNIQDLAP-SCAGFLFGVANTAGALAGVVGVCLSGYLIETTGsWTCVFHLVAIISNLGLGTFLVFGKA 435
Cdd:COG2271 282 GFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLLRE 360
|
..
gi 125347351 436 QR 437
Cdd:COG2271 361 TR 362
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
43-424 |
7.68e-34 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 130.92 E-value: 7.68e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 43 LGTCLLYCARVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLLA 122
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 123 HLGSGHLAfltfsRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSG 202
Cdd:TIGR00893 81 AYVSLYIL-----RVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 203 GLTLLWAYYVYRYLLN----------EKDLVLALGFLA--QGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILL 270
Cdd:TIGR00893 156 VLGIIWGVLWLKFIPDppqkakwlteEEKYIVVGGLLAeqQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 271 SWLPTFFKETFPNS--KGWVFNVVPWMLAIPASLFSGFISDRLISQGYRVITVRKFMQVMGLGLSSIFALClGHTTSFLK 348
Cdd:TIGR00893 236 TWFPTYLVQERGLSilEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFAT-NYVNIPYA 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 349 AMIFASASIGFQTFNHSGISVnIQDLAP-SCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWT------CVFHLVAII 421
Cdd:TIGR00893 315 ALALVALGFFGLGAGAIGWAL-ISDNAPgNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAgalmvvAALALIGAL 393
|
...
gi 125347351 422 SNL 424
Cdd:TIGR00893 394 SYL 396
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
41-397 |
4.29e-32 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 124.84 E-value: 4.29e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 41 LLLGTCLLYCAR-VTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFitvttP 119
Cdd:pfam07690 1 LFLAAFLAALGRsLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL-----G 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 120 LLAHLGSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFY 199
Cdd:pfam07690 76 LLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 200 FSGGLTLLWAYYVYRYLLNEKDlvlalGFLAQGLPVTKPSKVPWRQLFRKASVWAAICSqLCSACSFFILLSWLPTFFKE 279
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPES-----KRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQEV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 280 T-FPNSKGWVFNVVPWMLAIPASLFSGFISDRLisqgyrVITVRKFMQVMGLGLSSIFALCLGHTTSFLKAMIFASASIG 358
Cdd:pfam07690 230 LgLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL------GRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGF 303
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 125347351 359 FQTFNHSGISVNIQDLAP-SCAGFLFGVANTAGALAGVVG 397
Cdd:pfam07690 304 GFGLVFPALNALVSDLAPkEERGTASGLYNTAGSLGGALG 343
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
66-439 |
5.18e-31 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 124.09 E-value: 5.18e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 66 FGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVIllsASAWGFITVTTPLLAHLGSGHLAFLTFSRILTGLLQGV 145
Cdd:TIGR00894 71 FKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSI---GIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGS 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 146 YFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQ-CGWQSVFYFSG----GLTLLWAYYVYRY----- 215
Cdd:TIGR00894 148 VSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGivgcAWSLLWFVFPADDpsihp 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 216 --LLNEKDlvlALGFLAQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFFKET--FPNSKGWVFNV 291
Cdd:TIGR00894 228 ciSKFEKK---YINSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVlrVSGKENGLLSS 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 292 VPWMLAIPASLFSGFISDRLISQGY-RVITVRKFMQVMGLGLSSIFALCLGHTTS-FLKAMIFASASIGFQTFNHSGISV 369
Cdd:TIGR00894 305 LPYLFAWLCSIFAGYLADFLKSSKTlSLTAARKIFNGIGGLGPGIFAYALPYLSAaFYLTIIILTLANAVSSGPLAGVLI 384
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 125347351 370 NIQDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLIET--TGSWTCVFHLVAIISNLGLGTFLVFGKAQRVD 439
Cdd:TIGR00894 385 NSLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQdsKNVWLIVFLIMAFVNILCVIFYLIFGSAERQD 456
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
36-437 |
2.57e-27 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 112.67 E-value: 2.57e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 36 AWTGILLLGTCLL--YCARVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGF 113
Cdd:COG2223 3 RWRVLLLATLAFFlaFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 114 itvttPLLAHLGSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCG 193
Cdd:COG2223 83 -----GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 194 WQSVFYFSGGLTLLWAYYVYRYLLNEKdlvlalgflAQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWL 273
Cdd:COG2223 158 WRNAFLILGILLLVVAVLAWLFLRDPP---------AGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 274 PTFFKETFPNSK--GWVFNVVPWMLAIPASLFSGFISDRLisQGYRVITVrkFMQVMGLGLsSIFALCLGHTTSFLKAMI 351
Cdd:COG2223 229 PPYLVDQFGLSAatAGLLAALFALLGALGRPLGGWLSDRI--GGRRVLLI--VFALMALGL-LLLALALGSLWLFLVLFL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 352 FASASIGFqtfnhsGISVNIQDLA----PSCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVFHLVAIISNLGLG 427
Cdd:COG2223 304 LLGLALGG------GNGAVFALVPdifpTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALV 377
|
410
....*....|
gi 125347351 428 TFLVFGKAQR 437
Cdd:COG2223 378 LTLLLYRRPR 387
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
40-394 |
1.43e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 106.98 E-value: 1.43e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 40 ILLLGTCLLYCARVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTP 119
Cdd:COG2814 14 ALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 120 LlahlgSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFY 199
Cdd:COG2814 94 L-----APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 200 FSGGLTLLWayyvyryllnekdLVLALGFLAQGLPVTKPS-KVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFFK 278
Cdd:COG2814 169 VNAVLALLA-------------LLLLLRLLPESRPAARARlRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 279 ETFpnskGWVFNVVPWMLA------IPASLFSGFISDRLisqgyrvitVRKFMQVMGLGLSSIFALCLGHTTSFLKAMIF 352
Cdd:COG2814 236 EVL----GLSASAAGLLLAlfglggVLGALLAGRLADRF---------GRRRLLLIGLLLLALGLLLLALAGSLWLLLLA 302
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 125347351 353 ASASIGFQTFNHSGISVNIQDLAP-SCAGFLFGVANTAGALAG 394
Cdd:COG2814 303 LFLLGFGFGLLFPLLQALVAELAPpEARGRASGLYNSAFFLGG 345
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
64-432 |
4.62e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 99.96 E-value: 4.62e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 64 QDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILlsasaWGFITVTTPLLAHLGSGHLAFLTFSRILTGLLQ 143
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLL-----LGLLLLAVSTLLFAFATSYWQLLLARFLQGLAS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 144 GVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLwayyvyryllnekDLV 223
Cdd:cd17325 99 AAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL-------------ALV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 224 LALGFL-------AQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFFKETFPNSK---GWVFNVVP 293
Cdd:cd17325 166 LALLLLpeprpppNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPaqiGLLFGAQG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 294 WMLAIpASLFSGFISDRLisqgyrvitVRKFMQVMGLGLSSIFALCLGHTTSFLKAMIFASASIGFQTFNHSGISVNIQD 373
Cdd:cd17325 246 LASAL-SQPPAGKLSDRI---------GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLAD 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 374 LAPSCA-GFLFGVANTAGALAGVVGVCLSGYLIETTGsWTCVFHLVAIISNLGLGTFLVF 432
Cdd:cd17325 316 IVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
61-415 |
2.60e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 89.15 E-value: 2.60e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLlahlgSGHLAFLTFSRILTG 140
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL-----APSFALLLLARALAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 141 LLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRYLLNek 220
Cdd:cd17324 99 LAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPS-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 221 dlvlalgfLAQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFFKETFPNSKGWvfnvVPWMLAI-- 298
Cdd:cd17324 177 --------LPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSA----IIGLLLLfg 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 299 PASLFSGFISDRLISQGYRvitvRKFMQVMGLGLSSIFALCLGHTTSFLKAMIFASASIGFQtFNHSGISVNIQDLAPSC 378
Cdd:cd17324 245 VAGVVGSPLAGRLADRGGR----RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF-AAHSALQTRVLRLAPEA 319
|
330 340 350
....*....|....*....|....*....|....*..
gi 125347351 379 AGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVF 415
Cdd:cd17324 320 RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGW 356
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
41-430 |
1.07e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 87.48 E-value: 1.07e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 41 LLLGTCLLYCARVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITvttpl 120
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGA----- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 121 LAHLGSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQC--GWQSVF 198
Cdd:cd06174 76 LLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 199 YFSGGLTLLWAYYVYRYLLNEKDLVLALGFLAQglpvTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFFK 278
Cdd:cd06174 156 LIAAALALLAAILLLLVVPDPPESARAKNEEAS----SKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 279 ETFPNSK--GWVFNVVPWMLAIPASLFSGFISDRLISqgyrvitvRKFMQVMGLGLSSIFALCLGHTTSFLKAMIFAS-A 355
Cdd:cd06174 232 DLGGLSVavAGLLLSLFGLAGALGSLLLGLLSDRLIG--------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLlL 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 125347351 356 SIGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVFHLVAIISNLGLGTFL 430
Cdd:cd06174 304 GFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
61-405 |
4.61e-17 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 82.79 E-value: 4.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILlsasaWGFITVTTPLLAHLGSGHLAFLTFSRILTG 140
Cdd:TIGR00895 42 AISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLL-----WSILLFSVFTLLCALATNVTQLLILRFLAG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 141 LLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRYL---- 216
Cdd:TIGR00895 117 LGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLpesi 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 217 --LNEKDLVLALGFLAQGLP---------------VTKPSKVPWRQLFRKASVWAAI---CSQLCSACSFFILLSWLPTF 276
Cdd:TIGR00895 197 dfLVSKRPETVRRIVNAIAPqmqaeaqsalpeqksTQGTKRSVFKALFQGKTARITVllwLLYFMLLVGVYFLTNWLPKL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 277 FKET-FPNSKGWVFNVVPWMLAIPASLFSGFISDRLisqGYRVITVrkfmqvmGLGLSSIFALCLGHTTSFLKAMIFASA 355
Cdd:TIGR00895 277 MVELgFSLSLAATGGALFNFGGVIGSIIFGWLADRL---GPRVTAL-------LLLLGAVFAVLVGSTLFSPTLLLLLGA 346
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 125347351 356 SIG-FQTFNHSGISVNIQDL-APSCAGFLFGVANTAGALAGVVGVCLSGYLI 405
Cdd:TIGR00895 347 IAGfFVNGGQSGLYALMALFyPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
43-412 |
2.84e-16 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 80.01 E-value: 2.84e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 43 LGTCLLYCARVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLsasawGFITVttpLLA 122
Cdd:cd17312 10 LGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSA-----GLLLS---ALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 123 HLGSG---HLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFY 199
Cdd:cd17312 82 NIFMGfstSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 200 FSGGLTLLWAYYVYRYLLNEKDLVLALGFlaqglpvtkpskvpwrqlfrkasvwaaicsqlCSACSF---FILLSWLPTF 276
Cdd:cd17312 162 VPGIVGLVVAIILFFFLRDSPPYVWVLSL--------------------------------AYAFVYivrYACLDWGPLY 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 277 FKETFPNSK---GWVFNVVPwMLAIPASLFSGFISDRLIsQGYRVITVRKFMQVMGLGLSSIFALCLGHTTSFLKAMIFA 353
Cdd:cd17312 210 LYEVKGYSLidaGWFSSLYE-VGGIAGTILAGLLSDKLF-GGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIG 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 354 SASIGFQTFNHSGISvniQDLAPSCA-GFLFGVANTAGALAGVVGVCLSGYLIETTGSWT 412
Cdd:cd17312 288 FFVGGPINLIGGAAA---QDIGRKEAaGTATGFVGLFGYLGASLAGLPLGYIIDHYGWST 344
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
61-436 |
3.14e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 74.14 E-value: 3.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSAsawGFITVTTPLLAHLGSghLAFLTFSRILTG 140
Cdd:COG2807 43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLAL---LLLAAGLLLRSLAPS--VALLLAGTALIG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 141 LLQGVYFPALTSLLSQKVQESeRAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLwayyvyrYLLnek 220
Cdd:COG2807 118 AGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALL-------ALL--- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 221 dLVLALGFLAQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFFketfpNSKGWVFNVVPWMLA--- 297
Cdd:COG2807 187 -LWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-----RDAGLSAATAGLLLSlfq 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 298 ---IPASLFSGFISDRLISQGYRVITVrkfmqvMGLGLSSIFALCLGHTTSFLKAMIFASASIGFqTFnhSGISVNIQDL 374
Cdd:COG2807 261 lagIPGSLLVPLLADRLGDRRPLLLLL------GLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGG-LF--PLALTLIGLR 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 125347351 375 APSC--AGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVFHLVAIISNLGLGTFLVFGKAQ 436
Cdd:COG2807 332 ARTPaeAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGRPY 395
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
56-430 |
7.91e-14 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 72.66 E-value: 7.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 56 PVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLsasawGFITVTTPLLAHLGSGHLAFLTFS 135
Cdd:cd17475 16 PALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAV-----GLLLMGAAALLMALVGSYPVLLVL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 136 RILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGtlvtGGVGSVLL----DQCGWQSVFYFSGGLTLLWAYY 211
Cdd:cd17475 91 LFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLG----GALAAALLpplaLHYGWRAAFVVAGLVSILAAVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 212 VYRYLLNEKDLVLAlgflaqgLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFFKETF---PNSKGWV 288
Cdd:cd17475 167 FWLFYREPPAASAA-------TESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLglsVVAAGAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 289 FNVVPWmLAIPASLFSGFISDRLISQGYRVITVrkFMQVMGLGLSSIFALCLGHTTSFLKAMIFasASIGFQTFNHSGIS 368
Cdd:cd17475 240 LAVAQL-GGALGRIGLGRVSDRVFGGRRRPVLV--ITAAIAAAALLVLSLLSPGTPLWLLVLLL--ILLGLFAIGWNGLY 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 125347351 369 VN-IQDLAP-SCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVFHLVAIISNLGLGTFL 430
Cdd:cd17475 315 LTlVAESAGpEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
61-277 |
1.83e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 67.53 E-value: 1.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLlahlgSGHLAFLTFSRILTG 140
Cdd:COG0477 39 SIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL-----APSPELLIAARALQG 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 141 LLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRyLLNEK 220
Cdd:COG0477 114 IGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLR-LPESR 192
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 125347351 221 DLVLALGFLAQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFF 277
Cdd:COG0477 193 GLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLA 249
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
61-431 |
4.95e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 66.84 E-value: 4.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLlahlgSGHLAFLTFSRILTG 140
Cdd:cd17365 24 ALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAF-----AQSVLQLALLRFLTG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 141 LLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWayyvyryllnek 220
Cdd:cd17365 99 LGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLIL------------ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 221 dLVLALGFLAqglpvtkpskvpwrqlfrkasVWAAIcsqLCSACSFFILLSWLPTFFKET-FPNSKGWVFNVVPWMLAIP 299
Cdd:cd17365 167 -LPLLRGTLL---------------------LWVTF---FMGLLLVYLLNSWLPKLMVEAgYSLSQALTITLLLNIGGVI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 300 ASLFSGFISDRLisqgyrvitVRKFMQVMGLGLSSIFALCLGHTTSFLKAMIFASASIGFQTFnhsGISVNIQDLAP--- 376
Cdd:cd17365 222 GSLLLGWLADRF---------GPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVN---GAQVGLYALAArfy 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 125347351 377 --SCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVFHLVAIISNLGLGTFLV 431
Cdd:cd17365 290 ptEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLL 346
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
62-311 |
7.62e-12 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 66.50 E-value: 7.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 62 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLLAHLGSghlafLTFSRILTGL 141
Cdd:cd17327 32 MKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGG-----LIALRFFLGL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 142 LQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTG----GVGSVLLDQ--CGWQSVFYFSGGLTLLWAYYVYRY 215
Cdd:cd17327 107 FESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGllayGVFKILGVGglAGWRWLFIIEGLITIIIGLVIFFW 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 216 L---------LNEKDLVLALGFLA---QGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFFKETFPN 283
Cdd:cd17327 187 LpdnpskawfLTEEEKELAVERLRanqTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFY 266
|
250 260
....*....|....*....|....*....
gi 125347351 284 S-KGWVFNVVPWMLAIPASLFSGFISDRL 311
Cdd:cd17327 267 SlQTNLLSVPIGALGAVSLLIAALLSDRF 295
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
57-274 |
1.40e-11 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 65.75 E-value: 1.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 57 VCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLLAHLGSghlafLTFSR 136
Cdd:PRK11551 36 VAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS-----LLVAR 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 137 ILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRYL 216
Cdd:PRK11551 111 LLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWL 190
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 125347351 217 LNEKDLVLALGFLAQGLPVtkpskvpWRQLF---RKASVWAAICSQLCSACSFFILLSWLP 274
Cdd:PRK11551 191 PESRAFAQAAGAGKQRAPV-------LRALFgegRATATLLLWISYFFTLIVLYFLLNWLP 244
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
62-207 |
4.79e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 64.13 E-value: 4.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 62 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSasaWGFITVTTPLLAHLGSghLAFLTFSRILTGL 141
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG---LLLSAVALLLLPLATS--FWLLLLLLALLGL 300
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 125347351 142 LQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLL 207
Cdd:cd17325 301 GLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLL 366
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
40-411 |
5.14e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 63.79 E-value: 5.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 40 ILLLGTCLLY-CARVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVtt 118
Cdd:cd17329 3 VLLIGSFLNRlGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 119 pLLAHLGSGHLAFLTFsrILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQcGWQSVF 198
Cdd:cd17329 81 -LLGFAHSPWLFAIAL--VLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 199 YFSGGLTLLWAYYVYRYLLNEKdlvlalgfLAQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFFK 278
Cdd:cd17329 157 LAAAVLFLLAALVLLFLLPETR--------PKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 279 ETFPNSkgwvFNVVPWMLAIPA---SLFSGFISdRLISQGYRvitvRKFMqVMGLGLSSIFALCLGHTTSFLKAMIFAS- 354
Cdd:cd17329 229 EILGLG----ESLLGLLLALNAlliVLLQFPVA-RLVERFRL----RKIL-MIGILLFAIGFAVLAFANTLAVLILAMIv 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 125347351 355 ASIGfQTFNHSGISVNIQDLAP-SCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSW 411
Cdd:cd17329 299 LTLG-EMLVFPAVQTLVAALAPpDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPG 355
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
38-421 |
5.74e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 63.77 E-value: 5.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 38 TGILLLGTCLLYCARVTMPVCTVAMSQDFGWN--KKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFIT 115
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGlsLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 116 VTTPLlahlgSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQC--- 192
Cdd:cd17316 81 LLIGL-----LPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgd 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 193 -GWQSVFYFSGGLTLLWAYYVYRyllnekdlvlalgflaqglpvtkpskvpwrqlfrkasVWAAICSQLCSACSFFILLS 271
Cdd:cd17316 156 wGWRILFLIGALPALLALLLRRR-------------------------------------TLLLILLWFFISFGYYGLTT 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 272 WLPTFFKETFPNSKGWVFNVVPWM--LAIPASLFSGFISDRLisqgyrvitVRKFMQVMGLGLSSIFALCLGHTTSFLKA 349
Cdd:cd17316 199 FLPTYLQTVLGLSPATSSLYLLLIslGALVGALIAGLLSDRI---------GRKKTLVIGLILSGILALPLFYLLSGSPT 269
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 125347351 350 MIFASASIgfQTFNHSGISVNIQDLAP-----SCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVFHLVAII 421
Cdd:cd17316 270 LLLLLLFI--LSFFVGGVWGALYAYLAelfptEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALL 344
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
61-409 |
2.04e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 62.18 E-value: 2.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSAsawGFITVTTPLLAHLGSghLAFLTFSRILTG 140
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL---LLMALGLLLFALAPS--YPLLLLALFLLG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 141 LLQGVYFPALTSLLSQkVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQ---CGWQSVFYFSGGLTLLWAYYVYRYLL 217
Cdd:COG0738 108 LGLGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 218 NEkdlvlalgfLAQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFFKETF--PNSKGWVFNVVPWM 295
Cdd:COG0738 187 PE---------IEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLglSEATAALGLSLFWG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 296 LAIPASLFSGFISDRlisqgyrvITVRKFMQVMGLgLSSIFALCLGHTTSFLKAMIFASA-----SIGFQTFNHSGIsvn 370
Cdd:COG0738 258 GMTIGRFLGGFLLKR--------FGPVRLLRLSAL-LAAVGLLLALLAPGPWLALIGLALvglglSLMFPTIFSLAL--- 325
|
330 340 350
....*....|....*....|....*....|....*....
gi 125347351 371 iqDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLIETTG 409
Cdd:COG0738 326 --DGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG 362
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
43-415 |
2.38e-10 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 62.01 E-value: 2.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 43 LGTCLLYCARVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGgeKVILLSAsawGFITVTTPLLA 122
Cdd:TIGR00881 2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSN--PRVFLPI---GLILCAIVNLF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 123 HLGSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQV-GTLVTGGVGSVLLDQCGWQSVFYFS 201
Cdd:TIGR00881 77 FGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 202 GGLTLLWAYYVYRYLLNE-------KDLVLALGFLAQGLPVTKPSKVPWRQLFRKA----SVWAAICSQLCSACSFFILL 270
Cdd:TIGR00881 157 GIIAIIVSLICFLLLRDSpqscglpPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVllnkVLWYISLGYVFVYVVRTGIL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 271 SWLPTFFKET--FPNSKGWVFNVVPWMLAIPASLFSGFISDRLISQGYRVITVrKFMQVMGLGLSSIFalcLGHTTSFLK 348
Cdd:TIGR00881 237 DWSPLYLTQEkgFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAV-FFMALIIVSLLVYW---LNPAANPLM 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 125347351 349 AMIFAsASIGFQTFN-HSGISVNIQDLAPS-CAGFLFGVANTAGALAGVVGVCLSGYLIETTGsWTCVF 415
Cdd:TIGR00881 313 DLICL-FALGFLVYGpQMLIGVIASELAPKkAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG-WAGAF 379
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
64-433 |
2.26e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 58.76 E-value: 2.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 64 QDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLsasawGFITVTTPLLAHLGSGHLAFLTFSRILTGLLQ 143
Cdd:cd17489 24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLI-----GLLIFALATLLYLLATSVALLLVLRLIHGIGW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 144 GVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVyrYLLNEKDLV 223
Cdd:cd17489 99 GAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLV--FLVKDPPPV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 224 LALGflaqglpvTKPSKVPWRQLFRKASVWAAICSQLCSAcSFFILLSWLPTFFKETFPNSKGWVFNVVPWMLAIpASLF 303
Cdd:cd17489 177 AAEE--------AEAGTRAFRRLVEKKVLPPALILFLASI-AYGAISTFLPLYAAERGISNAGLFFTVYAIALLL-SRPF 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 304 SGFISDRLisqgyrvitVRKFMQVMGLGLSSIFALCLGHTTSFLKAMIFAS-ASIGFQTFNHSGISVNIQDLAPSCAGFL 382
Cdd:cd17489 247 SGKLSDRK---------GPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVlYGLGFGLLFPALQALAVDLVPPHRRGAA 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 125347351 383 FGVANTAGALAGVVGVCLSGYLIETTGsWTCVFHLVAIISNLGLGTFLVFG 433
Cdd:cd17489 318 NGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
86-409 |
2.82e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 55.68 E-value: 2.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 86 LTQVVGGHLGDRIGGEK-----VILLSASAWGFITVTTPLLAHLG-SGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQ 159
Cdd:COG2211 61 ITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSpTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTP 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 160 ES-ERAFTYSTVGAGSQVGTLVTGGVGSVLLD------QCGWQSVFYFSGGLTLLwayyvyryllnekdLVLALGFLAQG 232
Cdd:COG2211 141 DYeERTRLSSWRFAFAGLGGLLASVLPPPLVAafggdaALGYRLTALIFAVLGLL--------------AFLLTFFGTKE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 233 LPVTKPSKVP----WRQLFRKASVWAAICSQLCSACSFFILLSWLPTFFKETFPNSKGWV--FNVVPWMLAIPASLFSGF 306
Cdd:COG2211 207 RPVPEEEKVSlkesLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVglLLALYFLAALLGAPLWPR 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 307 ISDRLisqGyRVITVRKFMQVMGLGLSSIFALCLGHTTSFLKAMIFASASIGFQTFNHSGISVNIQDLA-----PSCAGF 381
Cdd:COG2211 287 LAKRF---G-KKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgRRREGL 362
|
330 340
....*....|....*....|....*...
gi 125347351 382 LFGVANTAGALAGVVGVCLSGYLIETTG 409
Cdd:COG2211 363 YFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
40-415 |
3.88e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 54.97 E-value: 3.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 40 ILLLGTCLLYC----ARVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFIT 115
Cdd:cd17355 3 VVLAVTFLILIlswgIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 116 VTTPLLAHLGSGHLAFLtfsrILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQ 195
Cdd:cd17355 83 VLLALATSLWQLYLLWG----LLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 196 SVFYFSGGLTLLWAYYVYRYLLNE-KDLVLAlgflAQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLP 274
Cdd:cd17355 159 TALLVLALLALLVLVPVLLLLRRRpADLALR----AYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 275 TFFKETF--PNSKGWVFNVVpWMLAIPASLFSGFISDRlISQGYRVITvrkfmqVMGLGLSSIFALCLGHTTSFlkAMIF 352
Cdd:cd17355 235 PYLADRGisPAAAAVALALI-GLFNIVGRLLSGWLGDR-YSPRRLLAA------SYALRALGLALLLLLPFPPL--ALLL 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 125347351 353 ASASIGFQTFNHSGISVNI--QDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVF 415
Cdd:cd17355 305 FAALFGLGWGATVPLTAALaaRYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAW 369
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
61-411 |
4.09e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 54.89 E-value: 4.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSAsawgFITVTTPLLAHLGSgHLAFLTFSRILTG 140
Cdd:cd17320 24 AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGL----LLFILASLLCALAS-SIEQLLIARFLQG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 141 LlqGVYFPALT--SLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRYlLN 218
Cdd:cd17320 99 L--GAAAGSVVarAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLF-LP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 219 EKDLVLALGFLAQGLPVTkpskvpWRQLFRKASVWAAIcsqLCSACSFFILLSWL---PTFFKETFPNSK---GWVFnvv 292
Cdd:cd17320 176 ETLPEEKRKPLLSSLLRA------YKRVLKNRRFLGYA---LALGLSFAGLFAYLaaaPFIYIEQLGLSPaqfGLLF--- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 293 pwMLAIPASLFSGFISDRLISQgyrvITVRKFMQVmGLGLSSIFALCLGHTTSFLKAMIFASASIGFQTFNHSGISVNIq 372
Cdd:cd17320 244 --ALNAIALILGSLLNGRLVRR----FGPRRLLRL-GLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPN- 315
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 125347351 373 dlAPSCAGFLFG-VANTAGALAGVVGVCLSGYLIETTGSW 411
Cdd:cd17320 316 --ATSLALEPFPhVAGTASALLGFLQFLIGALAGALVGLL 353
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
61-402 |
9.35e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 53.72 E-value: 9.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLlahlgSGHLAFLTFSRILTG 140
Cdd:cd17321 21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL-----APSLAFLIAARALQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 141 LLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLwayyvyryllnek 220
Cdd:cd17321 96 IGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 221 DLVLALGFlaqglpvtkpskvpwrqlfrkasvWAAICSQLCSACSFFILLSWLPTFFKETFPNSKGWV-FNVVPWMLAIP 299
Cdd:cd17321 163 ALLLARTF------------------------SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAgLALLPLALAML 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 300 -ASLFSGFISDRLisqGYRVITVRKFMqVMGLGLsSIFALCLGHTTSFLKAMIFASASIGFQTFNHSGISVNIQDLAPSC 378
Cdd:cd17321 219 vAAPLAGRLADRF---GPRLVLVAGLL-LTAVGL-LLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEK 293
|
330 340
....*....|....*....|....
gi 125347351 379 AGFLFGVANTAGALAGVVGVCLSG 402
Cdd:cd17321 294 AGAASGILNTARQLGGALGVALLG 317
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
39-363 |
6.30e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 51.47 E-value: 6.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 39 GILLLGTCLLYCARVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTT 118
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 119 PLlahlgSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQC-GWQSV 197
Cdd:cd17328 82 SF-----APNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 198 FYFSGGLTLLWAYYVYRYLLNEKDLVLALGFLAqgLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFF 277
Cdd:cd17328 157 FRVTGVLGVLLAILLLLFVREPPRGAAEGGVMA--KSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFF 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 278 KETFPNSK------GWVFNVVPWMLAIPASLFSGFISDRLisqGYRVITVRKFMQVMGLGLSSIFAL--CLGHTTSFLKA 349
Cdd:cd17328 235 LRAFGVGDlssadvGLIFGAITCIAGVLGVLLGGILADRL---RRKTPRADPLVCAVGLLAAAPFLFlaLVLALSNLLLA 311
|
330
....*....|....
gi 125347351 350 MIFASASIGFQTFN 363
Cdd:cd17328 312 WVLLFLGEFLLSLN 325
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
61-311 |
1.32e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 50.38 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVttpLLAHLGS-GHLAFLtfsRILT 139
Cdd:cd17371 24 ALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTL---LCGFAQNyWQLLIL---RALA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 140 GLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVG----TLVTGGVGSVLLDQCGWQSVFYFsGGLTLLWAYYVYRY 215
Cdd:cd17371 98 GLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGwllaTLLAALLFPLLPPEIAWRVLFLL-GALPALLVLFIRRF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 216 lLNEKDLVLAlgflAQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFI---LLSWLPTFFKETFPNSKGW--VFN 290
Cdd:cd17371 177 -VKEPPQWQA----ARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGyygITTWLPSYLTGERGLSFEGsaGYL 251
|
250 260
....*....|....*....|.
gi 125347351 291 VVPWMLAIPASLFSGFISDRL 311
Cdd:cd17371 252 VVTILGGFLGYLAGGFLADRI 272
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
73-431 |
2.23e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 49.50 E-value: 2.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 73 AGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSasawgFITVTTPLLAHLGSGHLAFLTFSRILTGLLqGVYFPALTS 152
Cdd:cd17330 36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLS-----LAGSAVSYVLLGLSRNLWLLFLARFLDGLT-GGNVSVAQA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 153 LLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRYLLnekdlvlalgflaqg 232
Cdd:cd17330 110 YIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP--------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 233 lpvtkpskvpwrqlfrkaSVWAAICSQLCSACSFFILLSWLPTFFKETFpnskGWVFNVVPWMLA---IPASLFSGFISD 309
Cdd:cd17330 175 ------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRF----GFSPSQIGLLLAlvgIAGILAQLLLIP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 310 RLISQGYRVITVRKFMQVMGLGLSSIFALCLGHTTSFLKAMIFASASIGFQTFNhSGISVNiqdLAPSCAGFLFGVANTA 389
Cdd:cd17330 233 RLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALS-ALLSKS---VPSKEQGKAQGIIQSL 308
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 125347351 390 GALAGVVGVCLSGYLIETTGSWTcVFHLVAIISNLGLGTFLV 431
Cdd:cd17330 309 QSLARIIGPLLAGPLYSFLGPGV-PFLLAAGLLLIALFLLSL 349
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
62-409 |
2.81e-06 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 49.16 E-value: 2.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 62 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEK--VILLSASAWGFITVTTPLLAHLGSGHLAFLTFsriLT 139
Cdd:cd17345 29 LIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRflAIGLILSAIINILIGFVPSATSSVGLMFILLF---LN 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 140 GLLQGVYFPALTSLLSQKVQESERAFTYS------TVGAGSqVGTLVTGGVGSVLLDQcgWQSVFYFSGGLTLLWAYYVY 213
Cdd:cd17345 106 GWFQGMGWPPSGRTMVHWFSKKERGTWTSiwnishNVGGGL-VGPLAGLGLAIFGDGW--WRGAFIFPAIIAIIVAVIVL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 214 RYLLNEKDLVlalgflaqGLPVT------KPSKVPWRQLFRKASVWAAICSQ--------LCSACSFFI------LLSWL 273
Cdd:cd17345 183 FLGKDTPESE--------GLPPIeeykgdYPEEADGEEEEQELSAWEIFVKYvlknkllwYIAIANVFVylvrygILDWA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 274 PTFFKET--FPNSKG-WVFNVVPWMlAIPASLFSGFISDRLIsQGYRVITVRKFMQVMGLGLSSIFalclgHTTSFLKAM 350
Cdd:cd17345 255 PTYLSEVkgFSKAQAmWAFSLFEWA-AIPGTLLAGWLSDKLF-KGRRAPTGIIFMILVIVALIVYW-----LAPNVLVDL 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 125347351 351 IFASAsIGF-----QTFnhsgISVNIQDLAPSCAgflfgvantAGALAGVVGVClsGYLIETTG 409
Cdd:cd17345 328 IALIA-LGFliygpVML----IGLQALELVPKKA---------AGTAAGLTGLF--GYLGGSVL 375
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
73-216 |
2.91e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 46.10 E-value: 2.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 73 AGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLsASAWGFITVTTPLLAHLGSGHLAFltfsRILTGLLQGVYFPALTS 152
Cdd:cd17391 242 SGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLG-ALLASALLYIPQAFVQTPWQLGIL----RFLLGLATGGLLPAINS 316
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 125347351 153 LLSQKVQESE--RAFTYSTVGA--GSQVGTLVTGGVGSVLldqcGWQSVFYFSGGLTLLWAYYVYRYL 216
Cdd:cd17391 317 LLAKITPKEVagRIFGYNQSFQylGNVAGPLLGSAIAAHF----GYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
61-426 |
3.41e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 45.68 E-value: 3.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSA--SAWGFItvttpLLAHLGSGHLAFLTFSrIL 138
Cdd:cd17353 28 PLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGilFGLGFI-----LSAFAISLPLLFLGYG-VL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 139 TGLLQGVYFPALTSLLsQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRYLLN 218
Cdd:cd17353 102 GGIGAGIGYITPVSTA-VKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRD 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 219 EKDLVLALGFLAQGL-PVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFFKETFPNSKGWVFNVVPwMLA 297
Cdd:cd17353 181 PPKGWVPPGVDPLANnAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVS-ILS 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 298 I---PASLFSGFISDRLisqgyrvitvrKFMQVMGLGLSSIFALCLGHTTSFLKAMIFASASIGFQTFNHSGISvniqdL 374
Cdd:cd17353 260 IfngGGRPFWGWLSDKI-----------GRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFA-----L 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 125347351 375 APSCAGFLFGVAN---------TAGALAGVVGVCLSGYLIeTTGSWTCVFHLVAIISNLGL 426
Cdd:cd17353 324 FPALTADFFGTKNagtnygllyTAKGVGGLIGPIIAAYVL-YTGGYNAAFIIAAALSLVAL 383
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
73-409 |
4.49e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 45.30 E-value: 4.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 73 AGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLLAHLGSGHLAFLTFSRILTGLLQGVYFPALTS 152
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 153 LLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLwayyvyryllnekdLVLALGFLAQG 232
Cdd:cd06173 116 LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLL--------------SALLLLFIRRP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 233 LPVTKPSKVP---------WRQLFRKASVWAAICSQLCSACSFFILLSWLPTFFKETFPNSKGWVFnvvpWMLAIPA--S 301
Cdd:cd06173 182 PPAAPGESSSlllrdlregLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYG----LLLAAFGvgA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 302 LFSGFISDRLISQGYRVITVRKFMQVMGLGLssifaLCLGHTTSFLKAMI-FASASIGFQTFNHSGISVNIQDLAPSCAG 380
Cdd:cd06173 258 LLGALLLGRLSKRRRRGRLLLIGALLLGLAL-----LVLGLSPSLWLLLAaLFLLGLAGGLFNVPLNTLLQLRVPDELRG 332
|
330 340
....*....|....*....|....*....
gi 125347351 381 FLFGVANTAGALAGVVGVCLSGYLIETTG 409
Cdd:cd06173 333 RVFSVYNALNSGAMPLGALLAGLLADALG 361
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
40-207 |
6.10e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.84 E-value: 6.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 40 ILLLGTCLLYCARVTMPVcTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFItvttp 119
Cdd:cd17370 204 LYLLAVALFALGNFSFAF-LILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALA----- 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 120 LLAHLGSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFY 199
Cdd:cd17370 278 YLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFL 357
|
....*...
gi 125347351 200 FSGGLTLL 207
Cdd:cd17370 358 FSAVLALI 365
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
256-422 |
8.35e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.33 E-value: 8.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 256 ICSQLCSACSFFILLSWLPTFFKETF---PNSKGWVFNVVPWMLAIpASLFSGFISDRlisqgyrvITVRKFMqVMGLGL 332
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLgisPTEIGLLLTLFSLGYAL-AQPLAGRLSDR--------FGRRRVL-LIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 333 SSIFALCLGHTTSFLKAMIFASASIGFQTFNHSGISVNIQDLAPSCA-GFLFGVANTAGALAGVVGVCLSGYLIETTGsW 411
Cdd:pfam07690 72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGLLASLFG-W 150
|
170
....*....|.
gi 125347351 412 TCVFHLVAIIS 422
Cdd:pfam07690 151 RAAFLILAILS 161
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
89-310 |
1.01e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 44.44 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 89 VVGGHLGDRIGGEKVILLSASAWGFITVTTPLLAHLGS-GHLA--FLTFSRILTGLLQGVYFPALTSLLSQKVQESERAF 165
Cdd:cd17369 62 VVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQiGILApiLLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGF 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 166 TYSTVGAGSQVGTLVTGGVGSVL--------LDQCGWQSVFYFSGGLtLLWAYYVyRYLLNEKDLVLALgfLAQGLPVTK 237
Cdd:cd17369 142 YGSFPQLGAPVGLLLATGVFLLLsallsdeaFLSWGWRIPFLLSAVL-VAVGLYI-RLRLEETPVFRRA--KEAGQVVRA 217
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 125347351 238 PSKVPWRQLFRkaSVWAAICSQLCSACSFFILLSWLPTFFKETFPNSKGWVFNVVPW--MLAIPASLFSGFISDR 310
Cdd:cd17369 218 PLVEVLRRHWR--ALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIasVVAAITIPLFGWLSDR 290
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
41-207 |
1.19e-04 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 43.93 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 41 LLLGTCLLYCARVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPL 120
Cdd:cd17488 8 MFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 121 lahlgSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYF 200
Cdd:cd17488 88 -----SSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYV 162
|
....*..
gi 125347351 201 SGGLTLL 207
Cdd:cd17488 163 PGIIAIL 169
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
11-207 |
1.21e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 11 PIPEETRKTPSAAAEDTRWSRPECQAWTGILLLGTC----LLYCARVTMPVctvAMSQDFGWNKKEAGIVLSSFFWGYCL 86
Cdd:cd17474 173 LPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFlyffLYFAFLTYLPF---LLELLYGISPIIIGLLFAGWSVLLAL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 87 TQVVGGH-LGDRIGGEKVILLSASAWGFITVTTPLLahlgsGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAF 165
Cdd:cd17474 250 GSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFV-----PSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGT 324
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 125347351 166 TYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLL 207
Cdd:cd17474 325 ASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALA 366
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
73-207 |
5.98e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 41.87 E-value: 5.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 73 AGIVLSSFFWGYCLTQVVGGHLGDRIGgEKVILLSASAWGFITVTTpllahlgsghLAF------LTFSRILTGLLQGvY 146
Cdd:cd17391 38 SGLAFSSTFLVSAIFSPIWGRLADRYG-RKPMLLRASLGMAIVIGL----------MAFvtnvwqLLILRLLQGVFSG-Y 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 125347351 147 FPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLL 207
Cdd:cd17391 106 VPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFL 166
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
40-214 |
6.78e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.83 E-value: 6.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 40 ILLLGTCLLYCARVTMPVCTVAMSQD-FGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTT 118
Cdd:cd06173 212 LLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 119 PLlahlgSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVF 198
Cdd:cd06173 292 GL-----SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
|
170
....*....|....*.
gi 125347351 199 YFSGGLTLLWAYYVYR 214
Cdd:cd06173 367 LLAGALLLLAALLLLL 382
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
70-433 |
2.55e-03 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 40.01 E-value: 2.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 70 KKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEkvILLSAsawGFITVTTPLLAHLGSGHLAFLTFSRILTGLLQGVYFPA 149
Cdd:cd17343 37 KSDLGLITSSQSLAYAISKFIGGVLSDQISAR--WLFSS---GLVLSGLTTVAFSGSSSVWVFSILWFLNGLAQGLGWPP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 150 LTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRYLLNE-KDLVLALGF 228
Cdd:cd17343 112 CAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEpSDVGLNNIE 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 229 LAQGLPVTKPSKVP---WRQLFRKASVWAAICSQLCSACSFFILLSWLPTFFKETFPNSK--GWVFNVVPWMLAIPASLF 303
Cdd:cd17343 192 EEESKGKKKKSPRGestLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQSAltGSSFMSSLEVGGFVGSIA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 304 SGFISDRLI----SQGY---RVITVRKFMQVMGLGLssiFALCLGHTTSFLKAMIFA-SASIGFQTFNHSGIS-VNIQDL 374
Cdd:cd17343 272 AGYLSDWAVakhgSSSRgnpRMPLALVFMAGLTVSL---HLFRVHITSDSSELFILLlGFLIGFSLYGPIAIFgVIANES 348
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 125347351 375 APScagFLFGVANTAGALAGVVGVCLSGY---LIETTGSWTCVFhLVAIISNLGLGTFLVFG 433
Cdd:cd17343 349 APS---HLCGTSHAIVALAANVGGVLAGLpfsYIAKHYDWRTAF-LLLEILCAITVVILFLL 406
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
61-405 |
2.64e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.87 E-value: 2.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSAsawgFITVTTPLLAHLgSGHLAFLTFSRILTG 140
Cdd:cd17504 21 TIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVL----AIYTAGSLLAAF-APNLPVLIAGRALQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 141 LLQGVyFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLtllwayyvyryllnek 220
Cdd:cd17504 96 IGGAV-FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPV---------------- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 221 dlVLALGFLAQGLPVtkpskvpwrQLFRKASVWAAICSQLCSACSFFILLSWLPTFFKETFPNSKG-WVFNVVPWMLAIP 299
Cdd:cd17504 159 --AVLLAALVPLIDL---------RLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGlGITEAGLLLLPGA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 300 -ASLFSGFISDRLIsqgyRVITVRKFMQV-MGLGLSSIFALCLGHTTSFLKAMIFASASIGFQTFNHSGISVNIQDLAPS 377
Cdd:cd17504 228 lVMLIAGPLAGRLI----ARVGPRRVLLIgLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPD 303
|
330 340
....*....|....*....|....*...
gi 125347351 378 CAGFLFGVANTAGALAGVVGVCLSGYLI 405
Cdd:cd17504 304 RTGIATGMNTVLRTIGSAIGPAIAGAIL 331
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
92-365 |
3.55e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 39.59 E-value: 3.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 92 GHLGDRIGGEKVILLSAS---AWGFITVTTPLLAHLGSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAF--- 165
Cdd:cd17367 61 GRLADRIGRRAALTLSVSlmaAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFyss 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 166 -TYSTVGAGSQVGTLVTGGVGSVL----LDQCGWQSVFYFSGGLTLLWAYyvyryllnekdlvlalgfLAQGLPVTKPSK 240
Cdd:cd17367 141 fQYVTLIGGQLLALGVLLVLQHTLgedqMAAWGWRIPFLLGGVLAVVVLW------------------LRRGLEETESFE 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 241 VPWRQLFRKASVWAAICSQ---------LCSACS--FFILLSWLPTFFKETFPNSKGWVF--NVVPWMLAIPASLFSGFI 307
Cdd:cd17367 203 AIAESNEASAGTLRELRRHprelllvvgLTAGGTlaFYTWTTYLQKFLVNTAGFSKGDATwiTTAALLVFMLLQPLGGRL 282
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 125347351 308 SDRlisqgyrvITVRKFMQVMGLG---LSSIFALCLGHTTSFLKAMIFASASIGFQTFNHS 365
Cdd:cd17367 283 SDR--------IGRRPLLLFFGIGgtlATVPLLSALDHTDSPYTAFALVLVGLVFLSGYTS 335
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
247-422 |
7.07e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.42 E-value: 7.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 247 FRKASVWAAICSQLCSACSFFILLSWLPTFFKETF--PNSKGWVFNVVPWMLAIpASLFSGFISDRLisqgyrvitVRKF 324
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGasPAQAGLVVTAYLLGAAL-GAPLAGRLADRF---------GRRR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 325 MQVMGLGLSSIFALCLGHTTSFLkAMIFASASIGF-QTFNHSGISVNIQDLAP-SCAGFLFGVANTAGALAGVVGVCLSG 402
Cdd:COG2814 77 VLLLGLLLFALGSLLCALAPSLW-LLLAARFLQGLgAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGG 155
|
170 180
....*....|....*....|
gi 125347351 403 YLIETTGsWTCVFHLVAIIS 422
Cdd:COG2814 156 LLADLFG-WRWVFLVNAVLA 174
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
67-207 |
7.39e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.31 E-value: 7.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 67 GWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAwgfITVTTPLLAHLGSGHLAFLTFSRILTGLLQGVY 146
Cdd:cd17477 219 GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALL---GALAALLLPLVPGLPLALLVLLFLWGGAAGPLY 295
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 125347351 147 FPALTsLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLL 207
Cdd:cd17477 296 TLALA-LAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALL 355
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
53-207 |
8.82e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 38.35 E-value: 8.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125347351 53 VTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVG-GHLGDRIGGEKVILLSA--SAWGFItvttpLLAHLGSGHL 129
Cdd:cd17331 225 MFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLvGPLTKRFGERSLLKLSValLAIGYL-----LLAFVTTVWQ 299
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 125347351 130 AFLTFsrILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLL 207
Cdd:cd17331 300 LLVLL--LPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGL 375
|
|
| |
