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Conserved domains on  [gi|38045963|ref|NP_899053|]
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zinc finger protein Aiolos isoform 4 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10603440)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|30718982
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
133-157 4.80e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.80e-05
                          10        20
                  ....*....|....*....|....*
gi 38045963   133 LMVHKRSHTGERPFQCNQCGASFTQ 157
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
160-183 3.35e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.35e-04
                          10        20
                  ....*....|....*....|....
gi 38045963   160 NLLRHIKLHTGEKPFKCHLCNYAC 183
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
192-213 4.36e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.36e-04
                          10        20
                  ....*....|....*....|..
gi 38045963   192 HLRTHSVEKPYKCEFCGRSYKQ 213
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
133-157 4.80e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.80e-05
                          10        20
                  ....*....|....*....|....*
gi 38045963   133 LMVHKRSHTGERPFQCNQCGASFTQ 157
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
160-183 3.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.35e-04
                          10        20
                  ....*....|....*....|....
gi 38045963   160 NLLRHIKLHTGEKPFKCHLCNYAC 183
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
192-213 4.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.36e-04
                          10        20
                  ....*....|....*....|..
gi 38045963   192 HLRTHSVEKPYKCEFCGRSYKQ 213
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
79-219 5.74e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 5.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045963  79 NAEEPEIPYSYSREYNEYE---NIKLERHVVSFDSSRPTSGKMNCDVCGLSCISFNVLMVHKRSHTGER-PFQCNQCGAS 154
Cdd:COG5048 219 NLENSSSSLPLTTNSQLSPkslLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNIS 298

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38045963 155 FTQKGNLLRHI--KLHTGE--KPFKC--HLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEE 219
Cdd:COG5048 299 FSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNN 369
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
133-157 4.80e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.80e-05
                          10        20
                  ....*....|....*....|....*
gi 38045963   133 LMVHKRSHTGERPFQCNQCGASFTQ 157
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
160-183 3.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.35e-04
                          10        20
                  ....*....|....*....|....
gi 38045963   160 NLLRHIKLHTGEKPFKCHLCNYAC 183
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
192-213 4.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.36e-04
                          10        20
                  ....*....|....*....|..
gi 38045963   192 HLRTHSVEKPYKCEFCGRSYKQ 213
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
79-219 5.74e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 5.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045963  79 NAEEPEIPYSYSREYNEYE---NIKLERHVVSFDSSRPTSGKMNCDVCGLSCISFNVLMVHKRSHTGER-PFQCNQCGAS 154
Cdd:COG5048 219 NLENSSSSLPLTTNSQLSPkslLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNIS 298

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38045963 155 FTQKGNLLRHI--KLHTGE--KPFKC--HLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEE 219
Cdd:COG5048 299 FSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNN 369
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 146-168 7.40e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 7.40e-04
                          10        20
                  ....*....|....*....|...
gi 38045963   146 FQCNQCGASFTQKGNLLRHIKLH 168
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
146-170 4.48e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.45  E-value: 4.48e-03
                          10        20
                  ....*....|....*....|....*
gi 38045963   146 FQCNQCGASFTQKGNLLRHIKLHTG 170
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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