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Conserved domains on  [gi|564112182|ref|NP_938185|]
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centrosomal protein of 97 kDa [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-248 6.88e-25

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 102.94  E-value: 6.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  45 THtLILDQNQLMKLEHLEHNPDLQQLSVACNRLVRMMNVCRLTQLRVLDLQNNSIGCIEGLKELQQLERLNLAGNNIKVM 124
Cdd:cd21340    5 TH-LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182 125 EQLHHCVSLQHLDLSDNNISQ----IGDVSRLSA----LQTLLLHGNIITTLRSApAHLPaHLRVLSLAENEIRDLTEVC 196
Cdd:cd21340   84 EGLENLTNLEELHIENQRLPPgeklTFDPRSLAAlsnsLRVLNISGNNIDSLEPL-APLR-NLEQLDASNNQISDLEELL 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564112182 197 -YLAPVRGLQQLSLLSNPcvscvssaVCD---YRPYVLSWCLGLELLDGVAVTQKE 248
Cdd:cd21340  162 dLLSSWPSLRELDLTGNP--------VCKkpkYRDKIILASKSLEVLDGKEITDTE 209
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
 439-458 7.32e-03

IQ calmodulin-binding motif; Calmodulin-binding motif.


:

Pssm-ID: 459869  Cd Length: 21  Bit Score: 34.22  E-value: 7.32e-03
                          10        20
                  ....*....|....*....|
gi 564112182  439 QDAAVRIQSWWRGQWTRQRH 458
Cdd:pfam00612   1 RKAAIKIQAAWRGYLARKRY 20
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-248 6.88e-25

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 102.94  E-value: 6.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  45 THtLILDQNQLMKLEHLEHNPDLQQLSVACNRLVRMMNVCRLTQLRVLDLQNNSIGCIEGLKELQQLERLNLAGNNIKVM 124
Cdd:cd21340    5 TH-LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182 125 EQLHHCVSLQHLDLSDNNISQ----IGDVSRLSA----LQTLLLHGNIITTLRSApAHLPaHLRVLSLAENEIRDLTEVC 196
Cdd:cd21340   84 EGLENLTNLEELHIENQRLPPgeklTFDPRSLAAlsnsLRVLNISGNNIDSLEPL-APLR-NLEQLDASNNQISDLEELL 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564112182 197 -YLAPVRGLQQLSLLSNPcvscvssaVCD---YRPYVLSWCLGLELLDGVAVTQKE 248
Cdd:cd21340  162 dLLSSWPSLRELDLTGNP--------VCKkpkYRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-213 1.38e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.47  E-value: 1.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  47 TLILDQNQLMKL-EHLEHNPDLQQLSVACNRLVRMMNVC-RLTQLRVLDLQNNSIGCI-EGLKELQQLERLNLAGNNIKV 123
Cdd:COG4886  117 SLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLgNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182 124 M-EQLHHCVSLQHLDLSDNNISQIGD-VSRLSALQTLLLHGNIITTLRSApAHLPaHLRVLSLAENEIRDLTEVCYLapv 201
Cdd:COG4886  197 LpEPLGNLTNLEELDLSGNQLTDLPEpLANLTNLETLDLSNNQLTDLPEL-GNLT-NLEELDLSNNQLTDLPPLANL--- 271

                        170
                 ....*....|..
gi 564112182 202 RGLQQLSLLSNP 213
Cdd:COG4886  272 TNLKTLDLSNNQ 283
LRR_9 pfam14580
Leucine-rich repeat;
114-263 1.21e-10

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 60.55  E-value: 1.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  114 LNLAGNNIKVMEQLHHCV-SLQHLDLSDNNISQIGDVSRLSALQTLLLHGNIITTLRSAPAHLPAHLRVLSLAENEIRDL 192
Cdd:pfam14580  24 LDLRGYKIPIIENLGATLdQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQEL 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564112182  193 TEVCYLAPVRGLQQLSLLSNPCvscvsSAVCDYRPYVLSWCLGLELLDGVAVTQKEGLKAEWLYSQGRGRV 263
Cdd:pfam14580 104 GDLDPLASLKKLTFLSLLRNPV-----TNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQ 169
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
47-212 2.12e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.48  E-value: 2.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  47 TLILDQNQLMKL-EHLEHNpdLQQLSVACNRLVRM------------MNVCRLTQL--------RVLDLQNNSIGCI-EG 104
Cdd:PRK15370 203 TLILDNNELKSLpENLQGN--IKTLYANSNQLTSIpatlpdtiqemeLSINRITELperlpsalQSLDLFHNKISCLpEN 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182 105 LKElqQLERLNLAGNNIKVMEQlHHCVSLQHLDLSDNNISQIGDVSRLSaLQTLLLHGNIITTLrsaPAHLPAHLRVLSL 184
Cdd:PRK15370 281 LPE--ELRYLSVYDNSIRTLPA-HLPSGITHLNVQSNSLTALPETLPPG-LKTLEAGENALTSL---PASLPPELQVLDV 353

                        170       180
                 ....*....|....*....|....*...
gi 564112182 185 AENEIRDLTEVcyLAPVrgLQQLSLLSN 212
Cdd:PRK15370 354 SKNQITVLPET--LPPT--ITTLDVSRN 377
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
 439-458 7.32e-03

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 459869  Cd Length: 21  Bit Score: 34.22  E-value: 7.32e-03
                          10        20
                  ....*....|....*....|
gi 564112182  439 QDAAVRIQSWWRGQWTRQRH 458
Cdd:pfam00612   1 RKAAIKIQAAWRGYLARKRY 20
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-248 6.88e-25

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 102.94  E-value: 6.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  45 THtLILDQNQLMKLEHLEHNPDLQQLSVACNRLVRMMNVCRLTQLRVLDLQNNSIGCIEGLKELQQLERLNLAGNNIKVM 124
Cdd:cd21340    5 TH-LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182 125 EQLHHCVSLQHLDLSDNNISQ----IGDVSRLSA----LQTLLLHGNIITTLRSApAHLPaHLRVLSLAENEIRDLTEVC 196
Cdd:cd21340   84 EGLENLTNLEELHIENQRLPPgeklTFDPRSLAAlsnsLRVLNISGNNIDSLEPL-APLR-NLEQLDASNNQISDLEELL 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564112182 197 -YLAPVRGLQQLSLLSNPcvscvssaVCD---YRPYVLSWCLGLELLDGVAVTQKE 248
Cdd:cd21340  162 dLLSSWPSLRELDLTGNP--------VCKkpkYRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-213 1.38e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.47  E-value: 1.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  47 TLILDQNQLMKL-EHLEHNPDLQQLSVACNRLVRMMNVC-RLTQLRVLDLQNNSIGCI-EGLKELQQLERLNLAGNNIKV 123
Cdd:COG4886  117 SLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLgNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182 124 M-EQLHHCVSLQHLDLSDNNISQIGD-VSRLSALQTLLLHGNIITTLRSApAHLPaHLRVLSLAENEIRDLTEVCYLapv 201
Cdd:COG4886  197 LpEPLGNLTNLEELDLSGNQLTDLPEpLANLTNLETLDLSNNQLTDLPEL-GNLT-NLEELDLSNNQLTDLPPLANL--- 271

                        170
                 ....*....|..
gi 564112182 202 RGLQQLSLLSNP 213
Cdd:COG4886  272 TNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-212 4.34e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 4.34e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  55 LMKLEHLEHNPDLQQLSVACNRLVRM-MNVCRLTQLRVLDLQNNSIGCI-EGLKELQQLERLNLAGNNIKVM-EQLHHCV 131
Cdd:COG4886  103 LSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLT 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182 132 SLQHLDLSDNNISQIGD-VSRLSALQTLLLHGNIITTLRSAPAHLPaHLRVLSLAENEIRDLTEVCYLApvrGLQQLSLL 210
Cdd:COG4886  183 NLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLPEPLANLT-NLETLDLSNNQLTDLPELGNLT---NLEELDLS 258


                 ..
gi 564112182 211 SN 212
Cdd:COG4886  259 NN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-212 2.86e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 99.62  E-value: 2.86e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  47 TLILDQNQLMKLEHLEHNPDLQQLSVACNRLVRmmnvcRLTQLRVLDLQNNSIGCI-EGLKELQQLERLNLAGNNIK-VM 124
Cdd:COG4886   78 SLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS-----NLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTdLP 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182 125 EQLHHCVSLQHLDLSDNNISQIGD-VSRLSALQTLLLHGNIITTLRSAPAHLPaHLRVLSLAENEIRDLTEVcyLAPVRG 203
Cdd:COG4886  153 EPLGNLTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPEPLGNLT-NLEELDLSGNQLTDLPEP--LANLTN 229


                 ....*....
gi 564112182 204 LQQLSLLSN 212
Cdd:COG4886  230 LETLDLSNN 238
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
23-168 3.58e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 3.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  23 VLDLSARGLQRLEPQLFRpDSHTHTLILDQNQLMKL-EHLEHNPDLQQLSVACNRLVRM-MNVCRLTQLRVLDLQNNSIG 100
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLT 218

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564112182 101 CI-EGLKELQQLERLNLAGNNIKVMEQLHHCVSLQHLDLSDNNISQIGDVSRLSALQTLLLHGNIITTL 168
Cdd:COG4886  219 DLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
89-213 4.56e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 4.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  89 LRVLDLQNNSIGCIEGLKELQQLERLNLAGNNikvmeQLHHCVSLQHLDLSDNNISQIGD-VSRLSALQTLLLHGNIITT 167
Cdd:COG4886   76 LLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLPEeLANLTNLKELDLSNNQLTD 150

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 564112182 168 LRSAPAHLPaHLRVLSLAENEIRDLTEVcyLAPVRGLQQLSLLSNP 213
Cdd:COG4886  151 LPEPLGNLT-NLKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNNQ 193
LRR_9 pfam14580
Leucine-rich repeat;
114-263 1.21e-10

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 60.55  E-value: 1.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  114 LNLAGNNIKVMEQLHHCV-SLQHLDLSDNNISQIGDVSRLSALQTLLLHGNIITTLRSAPAHLPAHLRVLSLAENEIRDL 192
Cdd:pfam14580  24 LDLRGYKIPIIENLGATLdQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQEL 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564112182  193 TEVCYLAPVRGLQQLSLLSNPCvscvsSAVCDYRPYVLSWCLGLELLDGVAVTQKEGLKAEWLYSQGRGRV 263
Cdd:pfam14580 104 GDLDPLASLKKLTFLSLLRNPV-----TNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQ 169
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
23-179 3.29e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.26  E-value: 3.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  23 VLDLSARGLQRLEPQLFRPDSHThTLILDQNQLMKL-EHLEHNPDLQQLSVACNRLVRMMNVCRLTQLRVLDLQNNSIGC 101
Cdd:COG4886  186 ELDLSNNQITDLPEPLGNLTNLE-ELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTD 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182 102 IEGLKELQQLERLNLAGNNIKVM--EQLHHCVSLQHLDLSDNNISQIGDVSRLSALQTLLLHGNIITTLRSAPAHLPAHL 179
Cdd:COG4886  265 LPPLANLTNLKTLDLSNNQLTDLklKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSL 344
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
47-212 2.12e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.48  E-value: 2.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  47 TLILDQNQLMKL-EHLEHNpdLQQLSVACNRLVRM------------MNVCRLTQL--------RVLDLQNNSIGCI-EG 104
Cdd:PRK15370 203 TLILDNNELKSLpENLQGN--IKTLYANSNQLTSIpatlpdtiqemeLSINRITELperlpsalQSLDLFHNKISCLpEN 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182 105 LKElqQLERLNLAGNNIKVMEQlHHCVSLQHLDLSDNNISQIGDVSRLSaLQTLLLHGNIITTLrsaPAHLPAHLRVLSL 184
Cdd:PRK15370 281 LPE--ELRYLSVYDNSIRTLPA-HLPSGITHLNVQSNSLTALPETLPPG-LKTLEAGENALTSL---PASLPPELQVLDV 353

                        170       180
                 ....*....|....*....|....*...
gi 564112182 185 AENEIRDLTEVcyLAPVrgLQQLSLLSN 212
Cdd:PRK15370 354 SKNQITVLPET--LPPT--ITTLDVSRN 377
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 17-191 1.14e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 57.49  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  17 NHRGPGVLDLSARG-------LQRLEPQLFRPDSHTHTLILDQNQLMKL------EHLEHNPDLQQLSVACN-------- 75
Cdd:COG5238  147 LKDPLGGNAVHLLGlaarlglLAAISMAKALQNNSVETVYLGCNQIGDEgieelaEALTQNTTVTTLWLKRNpigdegae 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  76 RLVRMmnVCRLTQLRVLDLQNNSIGC------IEGLKELQQLERLNLAGNNIK------VMEQLHHCVSLQHLDLSDNNI 143
Cdd:COG5238  227 ILAEA--LKGNKSLTTLDLSNNQIGDegvialAEALKNNTTVETLYLSGNQIGaegaiaLAKALQGNTTLTSLDLSVNRI 304

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564112182 144 SQIGDVsrlsALQTLLLHGNIITTL------------RSAPAHLPAHLRV--LSLAENEIRD 191
Cdd:COG5238  305 GDEGAI----ALAEGLQGNKTLHTLnlayngigaqgaIALAKALQENTTLhsLDLSDNQIGD 362
LRR_8 pfam13855
Leucine rich repeat;
87-143 1.25e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 1.25e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564112182   87 TQLRVLDLQNNSIGCIEG--LKELQQLERLNLAGNNIKVMEQ--LHHCVSLQHLDLSDNNI 143
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-212 5.21e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.32  E-value: 5.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  92 LDLQNNSIGCIEGLKELQQLERLNLAGNNIKVMEQLHHCVSLQHLDLSDNNisqigDVSRLSALQTLLLHGNIITTLRSA 171
Cdd:COG4886   57 LRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLPEE 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564112182 172 PAHLPaHLRVLSLAENEIRDLTEVcyLAPVRGLQQLSLLSN 212
Cdd:COG4886  132 LANLT-NLKELDLSNNQLTDLPEP--LGNLTNLKSLDLSNN 169
LRR_8 pfam13855
Leucine rich repeat;
109-163 6.56e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 6.56e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 564112182  109 QQLERLNLAGNNIKVMEQ--LHHCVSLQHLDLSDNNISQIGDVS--RLSALQTLLLHGN 163
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGN 59
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 87-120 1.02e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 45.70  E-value: 1.02e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 564112182   87 TQLRVLDLQNNSIGCIEGLKELQQLERLNLAGNN 120
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNN 34
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 24-196 1.28e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.82  E-value: 1.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  24 LDLSARGLQRLEPQLFRPDSHTHTL---ILDQNQL--MKLEHL-----EHNPDLQQLSVACNRL-----VRMMNVCRLTQ 88
Cdd:cd00116   86 LDLSDNALGPDGCGVLESLLRSSSLqelKLNNNGLgdRGLRLLakglkDLPPALEKLVLGRNRLegascEALAKALRANR 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  89 -LRVLDLQNNSIG------CIEGLKELQQLERLNLAGNNI--KVMEQLHHCV----SLQHLDLSDNNISQIGdvsrLSAL 155
Cdd:cd00116  166 dLKELNLANNGIGdagiraLAEGLKANCNLEVLDLNNNGLtdEGASALAETLaslkSLEVLNLGDNNLTDAG----AAAL 241

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 564112182 156 QTLLLHGNIittlrsapahlpaHLRVLSLAENEI-----RDLTEVC 196
Cdd:cd00116  242 ASALLSPNI-------------SLLTLSLSCNDItddgaKDLAEVL 274
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 109-153 1.31e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 45.31  E-value: 1.31e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 564112182  109 QQLERLNLAGNNIKVMEQLHHCVSLQHLDLSDNNisQIGDVSRLS 153
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNN--KITDLSDLA 43
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 132-168 2.90e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 2.90e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 564112182  132 SLQHLDLSDNNISQIGDVSRLSALQTL-LLHGNIITTL 168
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLdLSGNNKITDL 39
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 65-144 3.07e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 3.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  65 PDLQQLSVACNRLV-RMMNVCRLTQLRVLDLQNNSI-GCI-EGLKELQQLERLNLAGNNI--KVMEQLHHCVSLQHLDLS 139
Cdd:PLN00113 452 PSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFsGAVpRKLGSLSELMQLKLSENKLsgEIPDELSSCKKLVSLDLS 531


                 ....*
gi 564112182 140 DNNIS 144
Cdd:PLN00113 532 HNQLS 536
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 24-177 3.40e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.24  E-value: 3.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  24 LDLS-----ARGLQRLEpQLFRPDSHTHTLILDQNQLMK------LEHLEHNPDLQQLSVACNRLvrmMNVCrltqlrvl 92
Cdd:COG5238  269 LYLSgnqigAEGAIALA-KALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGI---GAQG-------- 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  93 dlqnnSIGCIEGLKELQQLERLNLAGNNIKV--MEQLHHCV----SLQHLDLSDNNISQIGDVSRLSALQTlllhgNIIT 166
Cdd:COG5238  337 -----AIALAKALQENTTLHSLDLSDNQIGDegAIALAKYLegntTLRELNLGKNNIGKQGAEALIDALQT-----NRLH 406

                        170
                 ....*....|.
gi 564112182 167 TLRSAPAHLPA 177
Cdd:COG5238  407 TLILDGNLIGA 417
LRR_8 pfam13855
Leucine rich repeat;
155-213 6.17e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 6.17e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564112182  155 LQTLLLHGNIITTLR-SAPAHLPaHLRVLSLAENEIRDLTEVCyLAPVRGLQQLSLLSNP 213
Cdd:pfam13855   3 LRSLDLSNNRLTSLDdGAFKGLS-NLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
67-121 1.28e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.28e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 564112182   67 LQQLSVACNRLVRMMNVC--RLTQLRVLDLQNNSIGCIEG--LKELQQLERLNLAGNNI 121
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
 439-458 7.32e-03

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 459869  Cd Length: 21  Bit Score: 34.22  E-value: 7.32e-03
                          10        20
                  ....*....|....*....|
gi 564112182  439 QDAAVRIQSWWRGQWTRQRH 458
Cdd:pfam00612   1 RKAAIKIQAAWRGYLARKRY 20
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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