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Conserved domains on  [gi|38505268|ref|NP_938190|]
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voltage-dependent T-type calcium channel subunit alpha-1G isoform 14 [Homo sapiens]

Protein Classification

ion transporter( domain architecture ID 11997982)

ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium across cell membranes

CATH:  1.10.287.70
PubMed:  15816170
TCDB:  1.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
742-968 2.32e-64

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 219.06  E-value: 2.32e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268    742 SKYFGRGIMIAILVNTLSMGIEYHEQPEE-LTNALEISNIVFTSLFALEMLLKLLVYGPFG-YIKNPYNIFDGVIVVISV 819
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268    820 WEIV---GQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD 896
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38505268    897 GDtlPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS-WAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Cdd:pfam00520  161 PD--NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1252-1524 3.90e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 189.79  E-value: 3.90e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1252 HKMFDHVVLVIIFLNCITIAMERPKIdPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFgeqAYLRSSWNVLDGLLV 1331
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQ-PEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1332 LISVIDILVSMVSdsgtkILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1411
Cdd:pfam00520   77 LPSLISLVLSSVG-----SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLF 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1412 KGKFFVCQGEDTRNitnksdcaeasyrwvrhkYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGvdqqpimnhNPWML 1491
Cdd:pfam00520  152 GGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAY 204
                          250       260       270
                   ....*....|....*....|....*....|...
gi 38505268   1492 LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1524
Cdd:pfam00520  205 IYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1576-1817 6.97e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 177.46  E-value: 6.97e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1576 SHYLDLFITGVIGLNVVTMAMEHYQQPQ-ILDEALKICNYIFTVIFVLESVFKLVAFGF-RRFFQDRWNQLDLAIVLLSI 1653
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1654 MGITLEEIEvnaslpiNPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD 1733
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1734 lecDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDqestcynTVISPIYFVSFVLTAQFVLVNVVI 1813
Cdd:pfam00520  154 ---KLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------EFWAYIYFVSFIILGGFLLLNLFI 223

                   ....
gi 38505268   1814 AVLM 1817
Cdd:pfam00520  224 AVII 227
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
80-406 6.01e-42

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 154.73  E-value: 6.01e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268     80 NPWFERISMLVILLNCVTLGMFRPCEDiacDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIfgKKCYLGDTWNRLDFFI 159
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP---EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGF--KKRYFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268    160 VIAGMLEYSLDLQN--VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCffvffifgivgvqLWAGLL 237
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLL-------------LLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268    238 rnrcflpenFSLplsvdleryyqtenedespficsqpreNGMrscrsvptlrgdggggppcgldyeaynsssnttcvnwn 317
Cdd:pfam00520  143 ---------FAI---------------------------IGY-------------------------------------- 148
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268    318 QYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Cdd:pfam00520  149 QLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFIAVIID 228
                          330
                   ....*....|
gi 38505268    397 QFSETKQRES 406
Cdd:pfam00520  229 NFQELTERTE 238
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
1846-2167 1.14e-10

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 67.10  E-value: 1.14e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1846 PQPHSPLgSPFLWPGVEGPDSPDSPKPGALH----PAAHARSASHFSLEHPT-MQPHP-------TELPGPDLLTVRKSG 1913
Cdd:pfam03154  243 PSPHPPL-QPMTQPPPPSQVSPQPLPQPSLHgqmpPMPHSLQTGPSHMQHPVpPQPFPltpqssqSQVPPGPSPAAPGQS 321
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1914 VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPkaqsgsvlsvHSQPADTSYILQLPKDAPHLLQPH-SAPTWGTIPK--L 1990
Cdd:pfam03154  322 QQRIHTPPSQSQLQSQQPPREQPLPPAPLSMP----------HIKPPPTTPIPQLPNPQSHKHPPHlSGPSPFQMNSnlP 391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1991 PPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSRedllAEEEPPSPRDLKKCYSVEAQSCQRRPTSWLdeqrrHSIAvscld 2070
Cdd:pfam03154  392 PPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQ----LPPPPAQPPVLTQSQSLPPPAASHPPTSGL-----HQVP----- 457
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   2071 sgSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPR---------TPPSPGICLRRRAPsSDSKDPLASG 2141
Cdd:pfam03154  458 --SQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSssgpvpaavSCPLPPVQIKEEAL-DEAEEPESPP 534
                          330       340
                   ....*....|....*....|....*.
gi 38505268   2142 PPDSmaaSPSPKKDVLSLSGLSSDPA 2167
Cdd:pfam03154  535 PPPR---SPSPEPTVVNTPSHASQSA 557
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
742-968 2.32e-64

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 219.06  E-value: 2.32e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268    742 SKYFGRGIMIAILVNTLSMGIEYHEQPEE-LTNALEISNIVFTSLFALEMLLKLLVYGPFG-YIKNPYNIFDGVIVVISV 819
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268    820 WEIV---GQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD 896
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38505268    897 GDtlPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS-WAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Cdd:pfam00520  161 PD--NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1252-1524 3.90e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 189.79  E-value: 3.90e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1252 HKMFDHVVLVIIFLNCITIAMERPKIdPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFgeqAYLRSSWNVLDGLLV 1331
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQ-PEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1332 LISVIDILVSMVSdsgtkILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1411
Cdd:pfam00520   77 LPSLISLVLSSVG-----SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLF 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1412 KGKFFVCQGEDTRNitnksdcaeasyrwvrhkYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGvdqqpimnhNPWML 1491
Cdd:pfam00520  152 GGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAY 204
                          250       260       270
                   ....*....|....*....|....*....|...
gi 38505268   1492 LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1524
Cdd:pfam00520  205 IYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1576-1817 6.97e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 177.46  E-value: 6.97e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1576 SHYLDLFITGVIGLNVVTMAMEHYQQPQ-ILDEALKICNYIFTVIFVLESVFKLVAFGF-RRFFQDRWNQLDLAIVLLSI 1653
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1654 MGITLEEIEvnaslpiNPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD 1733
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1734 lecDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDqestcynTVISPIYFVSFVLTAQFVLVNVVI 1813
Cdd:pfam00520  154 ---KLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------EFWAYIYFVSFIILGGFLLLNLFI 223

                   ....
gi 38505268   1814 AVLM 1817
Cdd:pfam00520  224 AVII 227
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
80-406 6.01e-42

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 154.73  E-value: 6.01e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268     80 NPWFERISMLVILLNCVTLGMFRPCEDiacDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIfgKKCYLGDTWNRLDFFI 159
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP---EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGF--KKRYFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268    160 VIAGMLEYSLDLQN--VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCffvffifgivgvqLWAGLL 237
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLL-------------LLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268    238 rnrcflpenFSLplsvdleryyqtenedespficsqpreNGMrscrsvptlrgdggggppcgldyeaynsssnttcvnwn 317
Cdd:pfam00520  143 ---------FAI---------------------------IGY-------------------------------------- 148
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268    318 QYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Cdd:pfam00520  149 QLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFIAVIID 228
                          330
                   ....*....|
gi 38505268    397 QFSETKQRES 406
Cdd:pfam00520  229 NFQELTERTE 238
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
1846-2167 1.14e-10

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 67.10  E-value: 1.14e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1846 PQPHSPLgSPFLWPGVEGPDSPDSPKPGALH----PAAHARSASHFSLEHPT-MQPHP-------TELPGPDLLTVRKSG 1913
Cdd:pfam03154  243 PSPHPPL-QPMTQPPPPSQVSPQPLPQPSLHgqmpPMPHSLQTGPSHMQHPVpPQPFPltpqssqSQVPPGPSPAAPGQS 321
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1914 VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPkaqsgsvlsvHSQPADTSYILQLPKDAPHLLQPH-SAPTWGTIPK--L 1990
Cdd:pfam03154  322 QQRIHTPPSQSQLQSQQPPREQPLPPAPLSMP----------HIKPPPTTPIPQLPNPQSHKHPPHlSGPSPFQMNSnlP 391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1991 PPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSRedllAEEEPPSPRDLKKCYSVEAQSCQRRPTSWLdeqrrHSIAvscld 2070
Cdd:pfam03154  392 PPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQ----LPPPPAQPPVLTQSQSLPPPAASHPPTSGL-----HQVP----- 457
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   2071 sgSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPR---------TPPSPGICLRRRAPsSDSKDPLASG 2141
Cdd:pfam03154  458 --SQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSssgpvpaavSCPLPPVQIKEEAL-DEAEEPESPP 534
                          330       340
                   ....*....|....*....|....*.
gi 38505268   2142 PPDSmaaSPSPKKDVLSLSGLSSDPA 2167
Cdd:pfam03154  535 PPPR---SPSPEPTVVNTPSHASQSA 557
PHA03247 PHA03247
large tegument protein UL36; Provisional
1848-2171 2.10e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 2.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268  1848 PHSPLGSPFlwPGVEGPDSPDSP-KPGALHPA----------AHARS----------ASHFSLEHPTMQPHPTELPGPDl 1906
Cdd:PHA03247 2489 PFAAGAAPD--PGGGGPPDPDAPpAPSRLAPAilpdepvgepVHPRMltwirgleelASDDAGDPPPPLPPAAPPAAPD- 2565
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268  1907 ltvrksgvsrtHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVlsvhsqPADTsyilqlPKDAPHLLQPHSAPTWGT 1986
Cdd:PHA03247 2566 -----------RSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRA------PVDD------RGDPRGPAPPSPLPPDTH 2622
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268  1987 IPKLPPPGRSPLAQRPLRRQAAirtdsldvqglgSREDLLAEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSI-- 2064
Cdd:PHA03247 2623 APDPPPPSPSPAANEPDPHPPP------------TVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAArp 2690
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268  2065 AVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLS-------PPSITIDPPESQGPRTPPSPGICLRRRAPSSdskdP 2137
Cdd:PHA03247 2691 TVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAarqaspaLPAAPAPPAVPAGPATPGGPARPARPPTTAG----P 2766
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 38505268  2138 LASGPPDSMAASPSPKKDVLSLSGLS----SDPADLDP 2171
Cdd:PHA03247 2767 PAPAPPAAPAAGPPRRLTRPAVASLSesreSLPSPWDP 2804
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
838-978 1.87e-03

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 43.78  E-value: 1.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   838 LMRVLKLVRFLPalqrQLVVLMKTMD-NVATFCMLLMLFIFIF---SILGMHLFGckFASErdgdtlpdrkNFDSLLWAI 913
Cdd:PLN03223 1303 LGRILKLMDFQP----RLGVITRTLWlAGADLMHFFVIFGMVFvgyAFIGHVIFG--NASV----------HFSDMTDSI 1366
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38505268   914 VTVFQILTQE--DWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFqAEGDANKSES 978
Cdd:PLN03223 1367 NSLFENLLGDitYFNEDLKNLTGLQFVVGMIYFYSYNIFVFMILFNFLLAIICDAF-GEVKANAAET 1432
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
742-968 2.32e-64

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 219.06  E-value: 2.32e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268    742 SKYFGRGIMIAILVNTLSMGIEYHEQPEE-LTNALEISNIVFTSLFALEMLLKLLVYGPFG-YIKNPYNIFDGVIVVISV 819
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268    820 WEIV---GQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD 896
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38505268    897 GDtlPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS-WAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Cdd:pfam00520  161 PD--NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1252-1524 3.90e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 189.79  E-value: 3.90e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1252 HKMFDHVVLVIIFLNCITIAMERPKIdPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFgeqAYLRSSWNVLDGLLV 1331
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQ-PEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1332 LISVIDILVSMVSdsgtkILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1411
Cdd:pfam00520   77 LPSLISLVLSSVG-----SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLF 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1412 KGKFFVCQGEDTRNitnksdcaeasyrwvrhkYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGvdqqpimnhNPWML 1491
Cdd:pfam00520  152 GGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAY 204
                          250       260       270
                   ....*....|....*....|....*....|...
gi 38505268   1492 LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1524
Cdd:pfam00520  205 IYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1576-1817 6.97e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 177.46  E-value: 6.97e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1576 SHYLDLFITGVIGLNVVTMAMEHYQQPQ-ILDEALKICNYIFTVIFVLESVFKLVAFGF-RRFFQDRWNQLDLAIVLLSI 1653
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1654 MGITLEEIEvnaslpiNPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD 1733
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1734 lecDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDqestcynTVISPIYFVSFVLTAQFVLVNVVI 1813
Cdd:pfam00520  154 ---KLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------EFWAYIYFVSFIILGGFLLLNLFI 223

                   ....
gi 38505268   1814 AVLM 1817
Cdd:pfam00520  224 AVII 227
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
80-406 6.01e-42

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 154.73  E-value: 6.01e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268     80 NPWFERISMLVILLNCVTLGMFRPCEDiacDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIfgKKCYLGDTWNRLDFFI 159
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP---EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGF--KKRYFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268    160 VIAGMLEYSLDLQN--VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCffvffifgivgvqLWAGLL 237
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLL-------------LLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268    238 rnrcflpenFSLplsvdleryyqtenedespficsqpreNGMrscrsvptlrgdggggppcgldyeaynsssnttcvnwn 317
Cdd:pfam00520  143 ---------FAI---------------------------IGY-------------------------------------- 148
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268    318 QYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Cdd:pfam00520  149 QLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFIAVIID 228
                          330
                   ....*....|
gi 38505268    397 QFSETKQRES 406
Cdd:pfam00520  229 NFQELTERTE 238
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
1846-2167 1.14e-10

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 67.10  E-value: 1.14e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1846 PQPHSPLgSPFLWPGVEGPDSPDSPKPGALH----PAAHARSASHFSLEHPT-MQPHP-------TELPGPDLLTVRKSG 1913
Cdd:pfam03154  243 PSPHPPL-QPMTQPPPPSQVSPQPLPQPSLHgqmpPMPHSLQTGPSHMQHPVpPQPFPltpqssqSQVPPGPSPAAPGQS 321
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1914 VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPkaqsgsvlsvHSQPADTSYILQLPKDAPHLLQPH-SAPTWGTIPK--L 1990
Cdd:pfam03154  322 QQRIHTPPSQSQLQSQQPPREQPLPPAPLSMP----------HIKPPPTTPIPQLPNPQSHKHPPHlSGPSPFQMNSnlP 391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1991 PPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSRedllAEEEPPSPRDLKKCYSVEAQSCQRRPTSWLdeqrrHSIAvscld 2070
Cdd:pfam03154  392 PPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQ----LPPPPAQPPVLTQSQSLPPPAASHPPTSGL-----HQVP----- 457
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   2071 sgSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPR---------TPPSPGICLRRRAPsSDSKDPLASG 2141
Cdd:pfam03154  458 --SQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSssgpvpaavSCPLPPVQIKEEAL-DEAEEPESPP 534
                          330       340
                   ....*....|....*....|....*.
gi 38505268   2142 PPDSmaaSPSPKKDVLSLSGLSSDPA 2167
Cdd:pfam03154  535 PPPR---SPSPEPTVVNTPSHASQSA 557
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1611-1822 2.53e-07

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 53.82  E-value: 2.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1611 ICNYIFTVIFVLESVFKLVAFGfRRFFQDRWNQLDLAIVLLSIMGITL---EEIEVNA---SLPINP------------- 1671
Cdd:pfam08016   15 IVFVVFFLYFVVEEILKIRKHR-PSYLRSVWNLLDLAIVILSVVLIVLniyRDFLADRlikSVEASPvtfidfdrvaqld 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   1672 TIIRIMR----VLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGdlecdeTHpceglgr 1747
Cdd:pfam08016   94 NLYRIILaflvFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG------TQ------- 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38505268   1748 HATFRNFGMAFLTLFRVSTGD-NWNGIMKDtlrdcdqestcyNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEE 1822
Cdd:pfam08016  161 APNFSNFVKSILTLFRTILGDfGYNEIFSG------------NRVLGPLLFLTFVFLVIFILLNLFLAIINDSYVE 224
PHA03247 PHA03247
large tegument protein UL36; Provisional
1848-2171 2.10e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 2.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268  1848 PHSPLGSPFlwPGVEGPDSPDSP-KPGALHPA----------AHARS----------ASHFSLEHPTMQPHPTELPGPDl 1906
Cdd:PHA03247 2489 PFAAGAAPD--PGGGGPPDPDAPpAPSRLAPAilpdepvgepVHPRMltwirgleelASDDAGDPPPPLPPAAPPAAPD- 2565
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268  1907 ltvrksgvsrtHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVlsvhsqPADTsyilqlPKDAPHLLQPHSAPTWGT 1986
Cdd:PHA03247 2566 -----------RSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRA------PVDD------RGDPRGPAPPSPLPPDTH 2622
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268  1987 IPKLPPPGRSPLAQRPLRRQAAirtdsldvqglgSREDLLAEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSI-- 2064
Cdd:PHA03247 2623 APDPPPPSPSPAANEPDPHPPP------------TVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAArp 2690
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268  2065 AVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLS-------PPSITIDPPESQGPRTPPSPGICLRRRAPSSdskdP 2137
Cdd:PHA03247 2691 TVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAarqaspaLPAAPAPPAVPAGPATPGGPARPARPPTTAG----P 2766
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 38505268  2138 LASGPPDSMAASPSPKKDVLSLSGLS----SDPADLDP 2171
Cdd:PHA03247 2767 PAPAPPAAPAAGPPRRLTRPAVASLSesreSLPSPWDP 2804
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
1864-2152 3.73e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.01  E-value: 3.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268  1864 PDSPDSPKPGALHPAAHARSASHFSLEHPTM---QPHPTELPGPDLLTvRKSGVSRT-------HSLPNDSYMCRHGSTA 1933
Cdd:PHA03307   65 FEPPTGPPPGPGTEAPANESRSTPTWSLSTLapaSPAREGSPTPPGPS-SPDPPPPTpppasppPSPAPDLSEMLRPVGS 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268  1934 EGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHllqPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDS 2013
Cdd:PHA03307  144 PGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETAR---APSSPPAEPPPSTPPAAASPRPPRRSSPISASASSP 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268  2014 LDVQGLGSREDLLAEEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPG 2093
Cdd:PHA03307  221 APAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSP 300
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38505268  2094 SRPKKKLSPPSITIDP--------------PESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSP 2152
Cdd:PHA03307  301 SSPGSGPAPSSPRASSsssssressssstsSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSR 373
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
1846-2171 5.86e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 5.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268  1846 PQPHSPLGSPFLWPGVEGPDSPDSPKPGALHP---AAHARSASHFSLEHPTMQPH-PTELPGPDLLTVRKSGVSRTHSLP 1921
Cdd:PHA03307  128 PSPAPDLSEMLRPVGSPGPPPAASPPAAGASPaavASDAASSRQAALPLSSPEETaRAPSSPPAEPPPSTPPAAASPRPP 207
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268  1922 NDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVlSVHSQPADTSYILQ----LPKDAPHLL--QPHSAPTWGTIPKLPPPGR 1995
Cdd:PHA03307  208 RRSSPISASASSPAPAPGRSAADDAGASSSD-SSSSESSGCGWGPEnecpLPRPAPITLptRIWEASGWNGPSSRPGPAS 286
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268  1996 SPLAQRPLRRQAairtdsldvqglgSREDLLAEEEPPSPRdlkkcySVEAQScqRRPTSWLDEQRRHSIAVSCLDSGSQP 2075
Cdd:PHA03307  287 SSSSPRERSPSP-------------SPSSPGSGPAPSSPR------ASSSSS--SSRESSSSSTSSSSESSRGAAVSPGP 345
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268  2076 HLGTDPSNLGGQPLGGPGSRPKKklSPPSitidPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKD 2155
Cdd:PHA03307  346 SPSRSPSPSRPPPPADPSSPRKR--PRPS----RAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDA 419
                         330
                  ....*....|....*.
gi 38505268  2156 VLSLSGLSSDPADLDP 2171
Cdd:PHA03307  420 GAASGAFYARYPLLTP 435
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
838-978 1.87e-03

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 43.78  E-value: 1.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268   838 LMRVLKLVRFLPalqrQLVVLMKTMD-NVATFCMLLMLFIFIF---SILGMHLFGckFASErdgdtlpdrkNFDSLLWAI 913
Cdd:PLN03223 1303 LGRILKLMDFQP----RLGVITRTLWlAGADLMHFFVIFGMVFvgyAFIGHVIFG--NASV----------HFSDMTDSI 1366
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38505268   914 VTVFQILTQE--DWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFqAEGDANKSES 978
Cdd:PLN03223 1367 NSLFENLLGDitYFNEDLKNLTGLQFVVGMIYFYSYNIFVFMILFNFLLAIICDAF-GEVKANAAET 1432
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
838-967 4.94e-03

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 40.72  E-value: 4.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505268    838 LMRVLKLVRFlpalQRQLVVLMKTM----DNVATFCMLLMLFIFIFSILGMHLFGCKFAserdgdtlpdrkNFDSLLWAI 913
Cdd:pfam08016  108 WLKLFKVLRF----NKTMSLFTKTLsrawKDLAGFALMFVIFFFAYAQFGYLLFGTQAP------------NFSNFVKSI 171
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 38505268    914 VTVFQILtqedWNKVLYNGMASTSSW-AALYFIALMTFGNYVLFNLLVAILVEGF 967
Cdd:pfam08016  172 LTLFRTI----LGDFGYNEIFSGNRVlGPLLFLTFVFLVIFILLNLFLAIINDSY 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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