|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
30-708 |
0e+00 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 547.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 30 TQQEKDSLVYQYLQKVDGWEQDLS---VPEFPEGLEWLNTEePISVYKDLCGKIVVLDFFTYCCINCIHLLPDLHALEHT 106
Cdd:PLN02919 370 AQNSGEGCVQQFVSYISDLESKKTatkVPEFPPKLDWLNTA-PLQFRRDLKGKVVILDFWTYCCINCMHVLPDLEFLEKK 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 107 YSDKDgLLIIGVHSAKFPNEKVLDNIKSAVLRYNITHPMVNDADASLWQELEVSCWPTLVILGPRGNMLFSLIGEGHKDK 186
Cdd:PLN02919 449 YKDQP-FTVVGVHSAKFDNEKDLEAIRNAVLRYNISHPVVNDGDMYLWRELGVSSWPTFAVVSPNGKLIAQLSGEGHRKD 527
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 187 LFLYTSIALKYYKDRGQIRDNKIGIKLYKDSLP---PSPLLFPGKVTVDQVTDRLVIADTGHHRILVVWKNGQIQYSIGG 263
Cdd:PLN02919 528 LDDLVEAALQYYGEKKLLDSTPLPLSLEKDNDPrllTSPLKFPGKLAIDLLNNRLFISDSNHNRIVVTDLDGNFIVQIGS 607
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 264 PN-PGRKDGIFSESTFNSPQGVA--IMNNIIYVADTENHLIRKIDLEAEKVSTVAGIGIQGTDKEGGAKGEQQPISSPWD 340
Cdd:PLN02919 608 TGeEGLRDGSFEDATFNRPQGLAynAKKNLLYVADTENHALREIDFVNETVRTLAGNGTKGSDYQGGKKGTSQVLNSPWD 687
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 341 VVFGTSgsevqrGDILWIAMAGTHQIWallldsgklpkKNELTKGTCLRFAGSGNEENRNNAYPHKAGFAQPSGLSLASE 420
Cdd:PLN02919 688 VCFEPV------NEKVYIAMAGQHQIW-----------EYNISDGVTRVFSGDGYERNLNGSSGTSTSFAQPSGISLSPD 750
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 421 dpWSCLFVADSESSTVRTVSLKDGAVKHLVGGerDPM---NLFAFGDVDGVGINAKLQHPLGVTWDKKrNLLYVADSYNH 497
Cdd:PLN02919 751 --LKELYIADSESSSIRALDLKTGGSRLLAGG--DPTfsdNLFKFGDHDGVGSEVLLQHPLGVLCAKD-GQIYVADSYNH 825
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 498 KIKVVDPKTKNCTTLAGTGdTNNVTSSSFTESTFNEPGGLCIGENGElLYVADTNNHQIKVMDLETKMVSVLPIFrsENA 577
Cdd:PLN02919 826 KIKKLDPATKRVTTLAGTG-KAGFKDGKALKAQLSEPAGLALGENGR-LFVADTNNSLIRYLDLNKGEAAEILTL--ELK 901
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 578 VVDGPflVEKQKTLPKLPKSAPS----IRLSPVTACAGqtlQFKLRLDLPSGSKLTEGVSSCWFLTAEGNEWLL----QG 649
Cdd:PLN02919 902 GVQPP--RPKSKSLKRLRRRSSAdtqvIKVDGVTSLEG---DLQLKISLPPGYHFSKEARSKFEVEVEPENAVDidpdEG 976
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42476013 650 QIAAGDIENIS---SQPTISLqipddclsleaiVSVSVFLYYCSADsSACMMKAILFSQPLQ 708
Cdd:PLN02919 977 TLSPDGRASLHfkrSSASAST------------GRISCKVYYCKED-EVCLYQSLVFEVPFE 1025
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
261-624 |
0e+00 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 546.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 261 IGGPNPGRKDGIFSESTFNSPQGVAIM-NNIIYVADTENHLIRKIDLEAEKVSTVAGIGIQGTDKEGGAKGEQQPISSPW 339
Cdd:cd14951 1 IGSGERGLKDGSFAEASFNEPQGLALLpGNILYVADTENHALRKIDLETGTVTTLAGTGEQGRDGEGGGPGREQPLSSPW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 340 DVVFGTSGsevqrgDILWIAMAGTHQIWALLLDSGklpkkneltkgTCLRFAGSGNEENRNNAYPHKAGFAQPSGLSLAs 419
Cdd:cd14951 81 DVAWGPED------DILYIAMAGTHQIWAYDLDTG-----------TCRVFAGSGNEGNRNGPYPHEAWFAQPSGLSLA- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 420 edPWSCLFVADSESSTVRTVSLKDGAVKHLVGGERDPMNLFAFGDVDGVGINAKLQHPLGVTWDKKrNLLYVADSYNHKI 499
Cdd:cd14951 143 --GWGELFVADSESSAIRAVSLKDGGVKTLVGGTRVGTGLFDFGDRDGPGAEALLQHPLGVAALPD-GSVYVADTYNHKI 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 500 KVVDPKTKNCTTLAGTGDTNNvtssSFTESTFNEPGGLCIGENGeLLYVADTNNHQIKVMDLETKMVSVLPIFRsenAVV 579
Cdd:cd14951 220 KRVDPATGEVSTLAGTGKAGY----KDLEAQFSEPSGLVVDGDG-RLYVADTNNHRIRRLDLPTEALEVLTLAH---RTL 291
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 42476013 580 DGPFLVEKQKTLPKLPKSAPSIRLSPVTacAGQTLQFKLRLDLPS 624
Cdd:cd14951 292 RPATPPAPGPLRLRVRFTAPAGQKLDDR--WGPSTRLKLSISPPE 334
|
|
| TlpA_like_DipZ_like |
cd03012 |
TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a ... |
55-182 |
6.27e-74 |
|
TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA family belong to this subfamily. TlpA is a disulfide reductase known to have a crucial role in the biogenesis of cytochrome aa3.
Pssm-ID: 239310 [Multi-domain] Cd Length: 126 Bit Score: 234.89 E-value: 6.27e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 55 PEFPEGLEWLNTEEPISVYkDLCGKIVVLDFFTYCCINCIHLLPDLHALEHTYSDkDGLLIIGVHSAKFPNEKVLDNIKS 134
Cdd:cd03012 1 PEFEGILQWLNTDKPLSLA-QLRGKVVLLDFWTYCCINCLHTLPYLTDLEQKYKD-DGLVVIGVHSPEFAFERDLANVKS 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 42476013 135 AVLRYNITHPMVNDADASLWQELEVSCWPTLVILGPRGNMLFSLIGEG 182
Cdd:cd03012 79 AVLRYGITYPVANDNDYATWRAYGNQYWPALYLIDPTGNVRHVHFGEG 126
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
226-556 |
9.52e-49 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 174.26 E-value: 9.52e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 226 PGKVTVDQvTDRLVIADTGHHRILVVWKNGQIQYSIGGPNPGRKDGIFSESTFNSPQGVAI-MNNIIYVADTENHLIRKI 304
Cdd:cd14953 25 PSGVAVDA-AGNLYVADRGNHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNTPSGVAVdAAGNLYVADTGNHRIRKI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 305 DLeAEKVSTVAGIGIQGTDKEGGAkgEQQPISSPWDVVFGTSGsevqrgdILWIAMAGTHQIwallldsgklpKKNElTK 384
Cdd:cd14953 104 TP-DGVVSTLAGTGTAGFSDDGGA--TAAQFNYPTGVAVDAAG-------NLYVADTGNHRI-----------RKIT-PD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 385 GTCLRFAGSGNEENRNNAYPHKAGFAQPSGLSLaseDPWSCLFVADSESSTVRTVSLkDGAVKHLVGgerdpmNLFAFGD 464
Cdd:cd14953 162 GVVTTVAGTGGAGYAGDGPATAAQFNNPTGVAV---DAAGNLYVADRGNHRIRKITP-DGVVTTVAG------TGTAGFS 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 465 VDGVGINAKLQHPLGVTWDKKRNlLYVADSYNHKIKVVDPKTKNcTTLAGTGDTNNVTSSSFTESTFNEPGGLCIGENGE 544
Cdd:cd14953 232 GDGGATAAQLNNPTGVAVDAAGN-LYVADSGNHRIRKITPAGVV-TTVAGGGAGFSGDGGPATSAQFNNPTGVAVDAAGN 309
|
330
....*....|..
gi 42476013 545 lLYVADTNNHQI 556
Cdd:cd14953 310 -LYVADTGNNRI 320
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
262-556 |
1.36e-42 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 157.31 E-value: 1.36e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 262 GGPNPGRKDGIFSESTFNSPQGVAI--MNNiIYVADTENHLIRKIDLEAEkVSTVAGIGIQGTDKEGGAkgeQQPISSPW 339
Cdd:cd14953 6 GSGTAGFSGGGGTAARFNSPSGVAVdaAGN-LYVADRGNHRIRKITPDGV-VTTVAGTGTAGFADGGGA---AAQFNTPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 340 DVVFGTSGSevqrgdiLWIAMAGTHQIWALLLDsgklpkkneltkGTCLRFAGSGNEENRNNAYPHKAGFAQPSGLSLas 419
Cdd:cd14953 81 GVAVDAAGN-------LYVADTGNHRIRKITPD------------GVVSTLAGTGTAGFSDDGGATAAQFNYPTGVAV-- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 420 eDPWSCLFVADSESSTVRTVSlKDGAVKHLVGGERdpmnlfAFGDVDGVGINAKLQHPLGVTWDKKRNlLYVADSYNHKI 499
Cdd:cd14953 140 -DAAGNLYVADTGNHRIRKIT-PDGVVTTVAGTGG------AGYAGDGPATAAQFNNPTGVAVDAAGN-LYVADRGNHRI 210
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 42476013 500 KVVDPKTkNCTTLAGTGDTNNVTSSSFTESTFNEPGGLCIGENGElLYVADTNNHQI 556
Cdd:cd14953 211 RKITPDG-VVTTVAGTGTAGFSGDGGATAAQLNNPTGVAVDAAGN-LYVADSGNHRI 265
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
220-558 |
3.60e-38 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 142.84 E-value: 3.60e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 220 PSPLLFPGKVTVDQvTDRLVIADTGHHRILVVWKNGQIQYSIGGpnPGRKDGifsesTFNSPQGVAI-MNNIIYVADTEN 298
Cdd:cd05819 4 PGELNNPQGIAVDS-SGNIYVADTGNNRIQVFDPDGNFITSFGS--FGSGDG-----QFNEPAGVAVdSDGNLYVADTGN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 299 HLIRKIDLEAEKVSTVAGIGIQGTDkeggakgeqqpISSPWDVVFGTSGSevqrgdiLWIAMAGTHQIWAllLDSGklpk 378
Cdd:cd05819 76 HRIQKFDPDGNFLASFGGSGDGDGE-----------FNGPRGIAVDSSGN-------IYVADTGNHRIQK--FDPD---- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 379 kneltkGTCLRFAGSGNEENrnnayphkAGFAQPSGLSLaseDPWSCLFVADSESSTVRTVSLKDGAVkhlvggerdpmn 458
Cdd:cd05819 132 ------GEFLTTFGSGGSGP--------GQFNGPTGVAV---DSDGNIYVADTGNHRIQVFDPDGNFL------------ 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 459 lFAFGdvDGVGINAKLQHPLGVTWDKKRNlLYVADSYNHKIKVVDPktkNCTTLAGTGdtnnvtSSSFTESTFNEPGGLC 538
Cdd:cd05819 183 -TTFG--STGTGPGQFNYPTGIAVDSDGN-IYVADSGNNRVQVFDP---DGAGFGGNG------NFLGSDGQFNRPSGLA 249
|
330 340
....*....|....*....|
gi 42476013 539 IGENGeLLYVADTNNHQIKV 558
Cdd:cd05819 250 VDSDG-NLYVADTGNNRIQV 268
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
278-585 |
1.01e-36 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 138.99 E-value: 1.01e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 278 FNSPQGVAIM-NNIIYVADTENHLIRKIDLEAEkvsTVAGIGIQGTDKEggakgeqqPISSPWDVVFGTSGSevqrgdiL 356
Cdd:cd05819 7 LNNPQGIAVDsSGNIYVADTGNNRIQVFDPDGN---FITSFGSFGSGDG--------QFNEPAGVAVDSDGN-------L 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 357 WIAMAGTHQIWALLLDSGKLPKkneltkgtclrFAGSGNEENrnnayphkaGFAQPSGLSLaseDPWSCLFVADSESSTV 436
Cdd:cd05819 69 YVADTGNHRIQKFDPDGNFLAS-----------FGGSGDGDG---------EFNGPRGIAV---DSSGNIYVADTGNHRI 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 437 RTVSlKDGAVkhlvggerdpmnLFAFGdvDGVGINAKLQHPLGVTWDKKRNlLYVADSYNHKIKVVDPktkNCTTLAGTG 516
Cdd:cd05819 126 QKFD-PDGEF------------LTTFG--SGGSGPGQFNGPTGVAVDSDGN-IYVADTGNHRIQVFDP---DGNFLTTFG 186
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42476013 517 DTNNVTSSsftestFNEPGGLCIGENGeLLYVADTNNHQIKVMDLETKMVSVLPIFRSENAVVDGPFLV 585
Cdd:cd05819 187 STGTGPGQ------FNYPTGIAVDSDG-NIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQFNRPSGL 248
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
407-560 |
1.14e-25 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 108.39 E-value: 1.14e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 407 AGFAQPSGLSLaseDPWSCLFVADSESSTVRTVSlKDGAVKHLVGGErdpmnlfAFGDVDGVGINAKLQHPLGVTWDKKR 486
Cdd:cd14953 20 ARFNSPSGVAV---DAAGNLYVADRGNHRIRKIT-PDGVVTTVAGTG-------TAGFADGGGAAAQFNTPSGVAVDAAG 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42476013 487 NLlYVADSYNHKIKVVDPKTkNCTTLAGTGDTNNVTSSSFTESTFNEPGGLCIGENGELlYVADTNNHQIKVMD 560
Cdd:cd14953 89 NL-YVADTGNHRIRKITPDG-VVSTLAGTGTAGFSDDGGATAAQFNYPTGVAVDAAGNL-YVADTGNHRIRKIT 159
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
223-439 |
7.21e-24 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 102.99 E-value: 7.21e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 223 LLFPGKVTVDqVTDRLVIADTGHHRILVVWKNGQIQYSIGGPNPGRK-DGIFSESTFNSPQGVAI-MNNIIYVADTENHL 300
Cdd:cd14953 131 FNYPTGVAVD-AAGNLYVADTGNHRIRKITPDGVVTTVAGTGGAGYAgDGPATAAQFNNPTGVAVdAAGNLYVADRGNHR 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 301 IRKIDLeAEKVSTVAGIGIQGTDKEGGAKGEQqpISSPWDVVFGTSGSevqrgdiLWIAMAGTHQIwaLLLDSGklpkkn 380
Cdd:cd14953 210 IRKITP-DGVVTTVAGTGTAGFSGDGGATAAQ--LNNPTGVAVDAAGN-------LYVADSGNHRI--RKITPA------ 271
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 42476013 381 eltkGTCLRFAGSGNEENRNNAYPHKAGFAQPSGLSLASEDPwscLFVADSESSTVRTV 439
Cdd:cd14953 272 ----GVVTTVAGGGAGFSGDGGPATSAQFNNPTGVAVDAAGN---LYVADTGNNRIRKI 323
|
|
| TlpA_like_family |
cd02966 |
TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are ... |
75-180 |
7.97e-23 |
|
TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.
Pssm-ID: 239264 [Multi-domain] Cd Length: 116 Bit Score: 93.84 E-value: 7.97e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 75 DLCGKIVVLDFFTYCCINCIHLLPDLHALEHTYSDkDGLLIIGVHSAKFPNEKVldniKSAVLRYNITHPMVNDADASLW 154
Cdd:cd02966 16 DLKGKVVLVNFWASWCPPCRAEMPELEALAKEYKD-DGVEVVGVNVDDDDPAAV----KAFLKKYGITFPVLLDPDGELA 90
|
90 100
....*....|....*....|....*.
gi 42476013 155 QELEVSCWPTLVILGPRGNMLFSLIG 180
Cdd:cd02966 91 KAYGVRGLPTTFLIDRDGRIRARHVG 116
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
220-570 |
1.52e-22 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 97.78 E-value: 1.52e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 220 PSPLLFPGKVTVDqVTDRLVIADTGHHRILVVwkngqiqysiggpNPgrKDGIFSE---STFNSPQGVAI-MNNIIYVAD 295
Cdd:COG4257 13 PAPGSGPRDVAVD-PDGAVWFTDQGGGRIGRL-------------DP--ATGEFTEyplGGGSGPHGIAVdPDGNLWFTD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 296 TENHLIRKIDLEAEKVSTVAGIGiqgtdkeggakgeqqPISSPWDVVFGTSGSevqrgdiLWIAMAGTHQIWALLLDSGK 375
Cdd:COG4257 77 NGNNRIGRIDPKTGEITTFALPG---------------GGSNPHGIAFDPDGN-------LWFTDQGGNRIGRLDPATGE 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 376 LpkkneltkgtclrfagsgneenrnNAYPHKAGFAQPSGLSLASED-PWsclfVADSESSTVRTVSLKDGAVKHLVGger 454
Cdd:COG4257 135 V------------------------TEFPLPTGGAGPYGIAVDPDGnLW----VTDFGANAIGRIDPDTGTLTEYAL--- 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 455 dpmnlfafgdvdgvgiNAKLQHPLGVTWDKKRNlLYVADSYNHKIKVVDPKTKNCTTLAGTGDTnnvtsssftestfNEP 534
Cdd:COG4257 184 ----------------PTPGAGPRGLAVDPDGN-LWVADTGSGRIGRFDPKTGTVTEYPLPGGG-------------ARP 233
|
330 340 350
....*....|....*....|....*....|....*..
gi 42476013 535 GGLCIGENGElLYVADTNNHQIKVMDLETKMVS-VLP 570
Cdd:COG4257 234 YGVAVDGDGR-VWFAESGANRIVRFDPDTELTEyVLP 269
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
166-437 |
1.39e-20 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 92.38 E-value: 1.39e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 166 VILGPRGNMLFSLIGEGHKDKLFLY-TSIALK---------YYKDRGQI--RDNKIGIKLYKDSLPPSPLLFPGKVTVDQ 233
Cdd:cd05819 32 QVFDPDGNFITSFGSFGSGDGQFNEpAGVAVDsdgnlyvadTGNHRIQKfdPDGNFLASFGGSGDGDGEFNGPRGIAVDS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 234 vTDRLVIADTGHHRILVVWKNGQIQYSIGGPNPGrkdgifsESTFNSPQGVAI-MNNIIYVADTENHLIRKIDLEAEKVS 312
Cdd:cd05819 112 -SGNIYVADTGNHRIQKFDPDGEFLTTFGSGGSG-------PGQFNGPTGVAVdSDGNIYVADTGNHRIQVFDPDGNFLT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 313 TVAGIGIqgtdkeggAKGEQqpiSSPWDVVFGTSGSevqrgdiLWIAMAGTHQIwallldsgklpkkneltkgtcLRFAG 392
Cdd:cd05819 184 TFGSTGT--------GPGQF---NYPTGIAVDSDGN-------IYVADSGNNRV---------------------QVFDP 224
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 42476013 393 SGNEENRN-NAYPHKAGFAQPSGLSLASEDpwsCLFVADSESSTVR 437
Cdd:cd05819 225 DGAGFGGNgNFLGSDGQFNRPSGLAVDSDG---NLYVADTGNNRIQ 267
|
|
| TrxA |
COG0526 |
Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, ... |
53-187 |
2.21e-20 |
|
Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440292 [Multi-domain] Cd Length: 139 Bit Score: 87.82 E-value: 2.21e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 53 SVPEFPegLEWLNtEEPISVyKDLCGKIVVLDFFTYCCINCIHLLPDLHALEHTYsdkDGLLIIGVHSAKFPnekvlDNI 132
Cdd:COG0526 7 PAPDFT--LTDLD-GKPLSL-ADLKGKPVLVNFWATWCPPCRAEMPVLKELAEEY---GGVVFVGVDVDENP-----EAV 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 42476013 133 KSAVLRYNITHPMVNDADASLWQELEVSCWPTLVILGPRGNMLFSLIGEGHKDKL 187
Cdd:COG0526 75 KAFLKELGLPYPVLLDPDGELAKAYGVRGIPTTVLIDKDGKIVARHVGPLSPEEL 129
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
225-558 |
2.71e-19 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 88.48 E-value: 2.71e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 225 FPGKVTVDqVTDRLVIADTGHHRILVVWKNGQIQYSIGgpNPGRKDGIfsestFNSPQGVAI-MNNIIYVADTENHLIRK 303
Cdd:cd14957 19 TPRGIAVD-SAGNIYVADTGNNRIQVFTSSGVYSYSIG--SGGTGSGQ-----FNSPYGIAVdSNGNIYVADTDNNRIQV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 304 IDLEAEKVSTvagIGIQGTdkeggakgEQQPISSPWDVVFGTSGSevqrgdiLWIAMAGTH--QIWalllDSgklpkkne 381
Cdd:cd14957 91 FNSSGVYQYS---IGTGGS--------GDGQFNGPYGIAVDSNGN-------IYVADTGNHriQVF----TS-------- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 382 ltKGTCLRFAGSGNEENRNnayphkagFAQPSGLSLaseDPWSCLFVADSESSTVRTVSlKDGAVKHLVGGErdpmnlfa 461
Cdd:cd14957 141 --SGTFSYSIGSGGTGPGQ--------FNGPQGIAV---DSDGNIYVADTGNHRIQVFT-SSGTFQYTFGSS-------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 462 fGDVDGvginaKLQHPLGVTWDKKRNlLYVADSYNHKIKVVDPKTKNCTTLAGTGDTNnvtsssfteSTFNEPGGLCIGE 541
Cdd:cd14957 199 -GSGPG-----QFSDPYGIAVDSDGN-IYVADTGNHRIQVFTSSGAYQYSIGTSGSGN---------GQFNYPYGIAVDN 262
|
330
....*....|....*..
gi 42476013 542 NGElLYVADTNNHQIKV 558
Cdd:cd14957 263 DGK-IYVADSNNNRIQV 278
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
226-558 |
3.62e-19 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 88.11 E-value: 3.62e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 226 PGKVTVDQVTDRLViADTGHHRILVVWKNGQIQYSIGGPNPGRkdgifseSTFNSPQGVAIMNN-IIYVADTENHLIRKI 304
Cdd:cd14956 15 PRGIAVDADDNVYV-ADARNGRIQVFDKDGTFLRRFGTTGDGP-------GQFGRPRGLAVDKDgWLYVADYWGDRIQVF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 305 DLEAEKVSTvagIGiqgtdKEGGAKGEqqpisspwdvvFGTSGSEVQRGD-ILWIAMAGTHQIWALLLDsgklpkknelt 383
Cdd:cd14956 87 TLTGELQTI---GG-----SSGSGPGQ-----------FNAPRGVAVDADgNLYVADFGNQRIQKFDPD----------- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 384 kGTCLRFAGSgneenrnnaYPHKAG-FAQPSGLSLaseDPWSCLFVADSESSTVRTVSlKDGAVKHLVGGErdpmnlFAF 462
Cdd:cd14956 137 -GSFLRQWGG---------TGIEPGsFNYPRGVAV---DPDGTLYVADTYNDRIQVFD-NDGAFLRKWGGR------GTG 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 463 gdvdgvgiNAKLQHPLGVTWDKKRNLlYVADSYNHKIKVVDPKTKNCTTLAGTGDTNNvtsssftesTFNEPGGLCIGEN 542
Cdd:cd14956 197 --------PGQFNYPYGIAIDPDGNV-FVADFGNNRIQKFTADGTFLTSWGSPGTGPG---------QFKNPWGVVVDAD 258
|
330
....*....|....*.
gi 42476013 543 GeLLYVADTNNHQIKV 558
Cdd:cd14956 259 G-TVYVADSNNNRVQR 273
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
461-558 |
4.46e-17 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 82.96 E-value: 4.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 461 AFGDVDGVGINAKLQHPLGVTWDKKRNlLYVADSYNHKIKVVDPKTKNcTTLAGTGdtnnvtSSSFTEST-----FNEPG 535
Cdd:cd14953 9 TAGFSGGGGTAARFNSPSGVAVDAAGN-LYVADRGNHRIRKITPDGVV-TTVAGTG------TAGFADGGgaaaqFNTPS 80
|
90 100
....*....|....*....|....
gi 42476013 536 GLCIGENGElLYVADTNNHQI-KV 558
Cdd:cd14953 81 GVAVDAAGN-LYVADTGNHRIrKI 103
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
222-558 |
7.89e-17 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 81.18 E-value: 7.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 222 PLLFPGKVTVDQvtDRLVIADTGHHRILVVWKNGQIQYSIGGPnpGRKDGifsesTFNSPQGVAI-MNNIIYVADTENHL 300
Cdd:cd14963 8 PLNKPMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGP--GTGPG-----EFKYPYGIAVdSDGNIYVADLYNGR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 301 IRKIDLEAEKVSTVAgigiqgtdKEGGAKGEQQPISspwdvVFGTSGSevqrgdiLWIAMAGTHQIwaLLLD-SGKLPKK 379
Cdd:cd14963 79 IQVFDPDGKFLKYFP--------EKKDRVKLISPAG-----LAIDDGK-------LYVSDVKKHKV--IVFDlEGKLLLE 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 380 neltkgtclrFAGSGNEENRnnayphkagFAQPSGLSLaseDPWSCLFVADSESSTVRTVSLKDGAVKHLVGGerdPMNL 459
Cdd:cd14963 137 ----------FGKPGSEPGE---------LSYPNGIAV---DEDGNIYVADSGNGRIQVFDKNGKFIKELNGS---PDGK 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 460 FAFGDVDGVGInaklqhplgvtwDKKRNLlYVADSYNHKIKVVDPKTKNCTTLAGTGDTNNvtsssftesTFNEPGGLCI 539
Cdd:cd14963 192 SGFVNPRGIAV------------DPDGNL-YVVDNLSHRVYVFDEQGKELFTFGGRGKDDG---------QFNLPNGLFI 249
|
330
....*....|....*....
gi 42476013 540 GENGElLYVADTNNHQIKV 558
Cdd:cd14963 250 DDDGR-LYVTDRENNRVAV 267
|
|
| Thioredoxin_8 |
pfam13905 |
Thioredoxin-like; Thioredoxins are small enzymes that participate in redox reactions, via the ... |
78-173 |
7.99e-17 |
|
Thioredoxin-like; Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.
Pssm-ID: 464033 [Multi-domain] Cd Length: 95 Bit Score: 76.19 E-value: 7.99e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 78 GKIVVLDFFTYCCINCIHLLPDLHALEHTYSDKDGLLIIGVHSAKFPNEkvLDNIKSAVLRYNITHPMVNDADASLWQEL 157
Cdd:pfam13905 1 GKVVLLYFGASWCKPCRRFTPLLKELYEKLKKKKNVEIVFVSLDRDLEE--FKDYLKKMPKDWLSVPFDDDERNELKRKY 78
|
90
....*....|....*.
gi 42476013 158 EVSCWPTLVILGPRGN 173
Cdd:pfam13905 79 GVNAIPTLVLLDPNGE 94
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
278-560 |
2.20e-15 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 76.95 E-value: 2.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 278 FNSPQGVAIMNNIIYVADTENHLIRKIDLEAEKVSTVAGigiqgtdkEGGAKGEqqpISSPWDVVfGTSGSEVqrgdilW 357
Cdd:cd14963 9 LNKPMGVAVSDGRIYVADTNNHRVQVFDYEGKFKKSFGG--------PGTGPGE---FKYPYGIA-VDSDGNI------Y 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 358 IAMAGTHQIwALLLDSGKLPKkneltkgtclRFAGSGNEENrnnayphkagFAQPSGLSLASEDpwscLFVADSESSTVR 437
Cdd:cd14963 71 VADLYNGRI-QVFDPDGKFLK----------YFPEKKDRVK----------LISPAGLAIDDGK----LYVSDVKKHKVI 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 438 TVSLKdGAVKHLVGGErdpmnlfafGDVDGvginaKLQHPLGVTWDKKRNLlYVADSYNHKIKVVDPKTKNCTTLAGTGD 517
Cdd:cd14963 126 VFDLE-GKLLLEFGKP---------GSEPG-----ELSYPNGIAVDEDGNI-YVADSGNGRIQVFDKNGKFIKELNGSPD 189
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 42476013 518 TNnvtsssfteSTFNEPGGLCIGENGElLYVADTNNHQIKVMD 560
Cdd:cd14963 190 GK---------SGFVNPRGIAVDPDGN-LYVVDNLSHRVYVFD 222
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
278-571 |
1.70e-14 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 74.29 E-value: 1.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 278 FNSPQGVAIM-NNIIYVADTENHLIRKIDLEAEKVSTVAgigiqgtdkeggakgeQQPISSPWDVVFGTSGSevqrgdiL 356
Cdd:COG4257 16 GSGPRDVAVDpDGAVWFTDQGGGRIGRLDPATGEFTEYP----------------LGGGSGPHGIAVDPDGN-------L 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 357 WIAMAGTHQIWALLLDSGKLpkkneltkgtcLRFAGSGNEenrnnAYPHKAGFAqPSGLslasedpwscLFVADSESSTV 436
Cdd:COG4257 73 WFTDNGNNRIGRIDPKTGEI-----------TTFALPGGG-----SNPHGIAFD-PDGN----------LWFTDQGGNRI 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 437 RTVSLKDGAVKhlvggerdpmnLFAFGDVDGVginaklqhPLGVTWDKKRNLlYVADSYNHKIKVVDPKTKNCTTLAGtg 516
Cdd:COG4257 126 GRLDPATGEVT-----------EFPLPTGGAG--------PYGIAVDPDGNL-WVTDFGANAIGRIDPDTGTLTEYAL-- 183
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 42476013 517 dtnnvtsssftESTFNEPGGLCIGENGELlYVADTNNHQIKVMDLETKMVSVLPI 571
Cdd:COG4257 184 -----------PTPGAGPRGLAVDPDGNL-WVADTGSGRIGRFDPKTGTVTEYPL 226
|
|
| NHL_like_4 |
cd14955 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
225-556 |
1.52e-12 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 68.76 E-value: 1.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 225 FPGKVTVDQVTDRLViADTGHHRILVVWKNGQIQYSIGGPNPGrkDGifsesTFNSPQGVAI--MNNIiYVADTENHLIR 302
Cdd:cd14955 17 SPSGIAVDSAGNVYV-ADTGNNRIQKFDSTGTFLTKWGSSGSG--DG-----QFYSPTGIAVdsDGNV-YVADTGNHRIQ 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 303 KIDleaekvST---VAGIGIQGTdkeggakGEQQpISSPWDVVFGTSGSevqrgdiLWIAMAGTHQIwaLLLDS-GKLpk 378
Cdd:cd14955 88 KFD------STgtfLTKWGSSGS-------GDGQ-FNSPSGIAVDSAGN-------VYVTDSGNNRI--QKFDSsGTF-- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 379 kneLTK-GTclrfAGSGNEEnrnnayphkagFAQPSGLSLASEDPwscLFVADSESSTVRTVSLkDGAVkhlvggerdpm 457
Cdd:cd14955 143 ---ITKwGS----FGSGDGQ-----------FNSPTGIAVDSAGN---VYVADTGNNRIQKFTS-TGTF----------- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 458 nLFAFGdVDGVGiNAKLQHPLGVTWDKKRNlLYVADSYNHKIKVVDPktkncttlAGTGDTnNVTSSSFTESTFNEPGGL 537
Cdd:cd14955 190 -LTKWG-SEGSG-DGQFNAPYGIAVDSAGN-VYVADTGNNRIQKFDS--------SGTFIT-KWGSEGSGDGQFNSPSGI 256
|
330
....*....|....*....
gi 42476013 538 CIGENGElLYVADTNNHQI 556
Cdd:cd14955 257 AVDSAGN-VYVADSGNNRI 274
|
|
| Bcp |
COG1225 |
Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; |
75-181 |
1.50e-11 |
|
Peroxiredoxin [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440838 [Multi-domain] Cd Length: 136 Bit Score: 62.58 E-value: 1.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 75 DLCGKIVVLDFFTYCCINCIHLLPDLHALEHTYSDKdGLLIIGVHSAKfpnekvLDNIKSAVLRYNITHPMVNDADASLW 154
Cdd:COG1225 18 DLRGKPVVLYFYATWCPGCTAELPELRDLYEEFKDK-GVEVLGVSSDS------DEAHKKFAEKYGLPFPLLSDPDGEVA 90
|
90 100
....*....|....*....|....*..
gi 42476013 155 QELEVSCWPTLVILGPRGNMLFSLIGE 181
Cdd:COG1225 91 KAYGVRGTPTTFLIDPDGKIRYVWVGP 117
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
260-558 |
3.41e-11 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 64.61 E-value: 3.41e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 260 SIGGPnpGRKDGifsesTFNSPQGVAI-MNNIIYVADTENHLIrkidleaekvstvagigiQGTDKEGGAKGEqqpissp 338
Cdd:cd14956 1 SWGGR--GSGPG-----QFKDPRGIAVdADDNVYVADARNGRI------------------QVFDKDGTFLRR------- 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 339 wdvvFGTSGSEV-QRGDILWIAMAGTHQIWAllldsgklpkkNELTKGTCLRFAGSGNEENRNNAYPHKAG-FAQPSGls 416
Cdd:cd14956 49 ----FGTTGDGPgQFGRPRGLAVDKDGWLYV-----------ADYWGDRIQVFTLTGELQTIGGSSGSGPGqFNAPRG-- 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 417 lASEDPWSCLFVADSESSTVRTVSLkDGAVkhlvggerdpmnLFAFGDVD--GVGINAklqhPLGVTWDKKRNLlYVADS 494
Cdd:cd14956 112 -VAVDADGNLYVADFGNQRIQKFDP-DGSF------------LRQWGGTGiePGSFNY----PRGVAVDPDGTL-YVADT 172
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42476013 495 YNHKIKVVDPKTKNCTTLAGTGDTNnvtsssfteSTFNEPGGLCIGENGElLYVADTNNHQIKV 558
Cdd:cd14956 173 YNDRIQVFDNDGAFLRKWGGRGTGP---------GQFNYPYGIAIDPDGN-VFVADFGNNRIQK 226
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
426-584 |
2.72e-10 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 61.25 E-value: 2.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 426 LFVADSESSTVRTVSLKDGAVKHLVGgerdpmnlfafgdvdgVGinaklQHPLGVTWDKKRNLLYVADSYNHKIKVVDPK 505
Cdd:COG3391 82 LYVANSGSGRVSVIDLATGKVVATIP----------------VG-----GGPRGLAVDPDGGRLYVADSGNGRVSVIDTA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 506 TKNCTTLAGTGdtnnvtsssftestfNEPGGLCIGENGELLYVADTNNHQI----KVMDLET-KMVSVLPIFRSENAVV- 579
Cdd:COG3391 141 TGKVVATIPVG---------------AGPHGIAVDPDGKRLYVANSGSNTVsvivSVIDTATgKVVATIPVGGGPVGVAv 205
|
....*..
gi 42476013 580 --DGPFL 584
Cdd:COG3391 206 spDGRRL 212
|
|
| NHL_like_6 |
cd14962 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
406-570 |
3.49e-10 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 61.45 E-value: 3.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 406 KAGFAQPSGLSLaseDPWSCLFVADSESSTVRTVSLKDGAVkHLVGGERDPMnlfafgdvdgvginakLQHPLGVTWDKK 485
Cdd:cd14962 8 KEALTRPYGVAA---DGRGRIYVADTGRGAVFVFDLPNGKV-FVIGNAGPNR----------------FVSPIGVAIDAN 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 486 RNLlYVADSYNHKIKVVDPKTKNCTTLAGTGDtnnvtsssftestFNEPGGLCIGENGELLYVADTNNHQIKVMDLETKM 565
Cdd:cd14962 68 GNL-YVSDAELGKVFVFDRDGKFLRAIGAGAL-------------FKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRL 133
|
....*
gi 42476013 566 VSVLP 570
Cdd:cd14962 134 LFDIG 138
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
342-566 |
4.17e-10 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 61.14 E-value: 4.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 342 VFGTSGSE-----------VQRGDILWIAMAGTHQIWALlldsgklpkknELTKGTCLRFAGSGNEENrnnayphkaGFA 410
Cdd:cd14956 1 SWGGRGSGpgqfkdprgiaVDADDNVYVADARNGRIQVF-----------DKDGTFLRRFGTTGDGPG---------QFG 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 411 QPSGLSLAsEDPWscLFVADSESSTVRTVSLkDGAVKHLvGGERDPMNlfafGDVDGVGinaklqhplGVTWDKKRNLlY 490
Cdd:cd14956 61 RPRGLAVD-KDGW--LYVADYWGDRIQVFTL-TGELQTI-GGSSGSGP----GQFNAPR---------GVAVDADGNL-Y 121
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42476013 491 VADSYNHKIKVVDPKTKNCTTLAGTGDTnnvtsssftESTFNEPGGLCIGENGELlYVADTNNHQIKVMDLETKMV 566
Cdd:cd14956 122 VADFGNQRIQKFDPDGSFLRQWGGTGIE---------PGSFNYPRGVAVDPDGTL-YVADTYNDRIQVFDNDGAFL 187
|
|
| NHL_like_6 |
cd14962 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
409-564 |
4.19e-10 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 61.06 E-value: 4.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 409 FAQPSGLSLASEDPwscLFVADSESstvrtvslkdGAVKHLVGGERdPMNLFafgdvdgvGINAKLQHPLGVTWDKKRNL 488
Cdd:cd14962 56 FVSPIGVAIDANGN---LYVSDAEL----------GKVFVFDRDGK-FLRAI--------GAGALFKRPTGIAVDPAGKR 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42476013 489 LYVADSYNHKIKVVDPKTKNCTTLAGTGDtnnvtsssfTESTFNEPGGLCIGENGElLYVADTNNHQIKVMDLETK 564
Cdd:cd14962 114 LYVVDTLAHKVKVFDLDGRLLFDIGKRGS---------GPGEFNLPTDLAVDRDGN-LYVTDTMNFRVQIFDADGK 179
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
165-436 |
5.72e-10 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 60.77 E-value: 5.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 165 LVILGPRGNMLFSLIGEGHKDKLFLY-TSIALK---------YYKDRGQIRDNKiGIklYKDSLPPSP----LLFPGKVT 230
Cdd:cd14963 32 VQVFDYEGKFKKSFGGPGTGPGEFKYpYGIAVDsdgniyvadLYNGRIQVFDPD-GK--FLKYFPEKKdrvkLISPAGLA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 231 VDQvtDRLVIADTGHHRILVVWKNGQIQYSIGGPnpGRKDGifsesTFNSPQGVAIM-NNIIYVADTENHLIRKIDLEAE 309
Cdd:cd14963 109 IDD--GKLYVSDVKKHKVIVFDLEGKLLLEFGKP--GSEPG-----ELSYPNGIAVDeDGNIYVADSGNGRIQVFDKNGK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 310 KVSTVAgigiqgtdkegGAKGEQQPISSPWDVVFGTSGsevqrgdILWIAMAGTHQIWALlldsgkLPKKNELTKgtclr 389
Cdd:cd14963 180 FIKELN-----------GSPDGKSGFVNPRGIAVDPDG-------NLYVVDNLSHRVYVF------DEQGKELFT----- 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 42476013 390 FAGSGNEENRNNAyphkagfaqPSGLSLaseDPWSCLFVADSESSTV 436
Cdd:cd14963 231 FGGRGKDDGQFNL---------PNGLFI---DDDGRLYVTDRENNRV 265
|
|
| NHL_TRIM71_like |
cd14954 |
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ... |
225-558 |
1.15e-09 |
|
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 59.87 E-value: 1.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 225 FPGKVTVDQvTDRLVIADTGHHRILVVWKNGQIQYSIGGPnpGRKDGifsesTFNSPQGVAI-MNNIIYVADTENHliRk 303
Cdd:cd14954 72 RPAGVAVNS-RGRIIVADKDNHRIQVFDLNGRFLLKFGER--GTKNG-----QFNYPWGVAVdSEGRIYVSDTRNH--R- 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 304 idleaekvstvagigIQGTDKEGgakgeqQPISSpwdvvFGTSGSevqrgdilwiamagthqiwallldsgkLPKKnelt 383
Cdd:cd14954 141 ---------------VQVFDSDG------QFIRK-----FGFEGA---------------------------GPGQ---- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 384 kgtclrfagsgneenrnnayphkagFAQPSGLSLASEDPwscLFVADSESSTVRTVSLkDGAVKHLVGGErdpmnlfafG 463
Cdd:cd14954 164 -------------------------LDSPRGVAVNPDGN---IVVSDFNNHRLQVFDP-DGQFLRFFGSE---------G 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 464 DVDGvginaKLQHPLGVTWDKKRNLLyVADSYNHKIKVVDPKTKNCTTLAGTGDtnnvtsssfTESTFNEPGGLCIGENG 543
Cdd:cd14954 206 SGNG-----QFKRPRGVAVDDEGNII-VADSGNHRVQVFSPDGEFLCSFGTEGN---------GEGQFDRPSGVAVTPDG 270
|
330
....*....|....*
gi 42476013 544 eLLYVADTNNHQIKV 558
Cdd:cd14954 271 -RIVVVDRGNHRIQV 284
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
459-566 |
1.92e-09 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 59.23 E-value: 1.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 459 LFAFGDVDGvgINAKLQHPLGVTWDKKRNLlYVADSYNHKIKVVDPKTKNCTTLAGTGDTNNVTSssftestfnePGGLC 538
Cdd:cd14963 42 KKSFGGPGT--GPGEFKYPYGIAVDSDGNI-YVADLYNGRIQVFDPDGKFLKYFPEKKDRVKLIS----------PAGLA 108
|
90 100
....*....|....*....|....*...
gi 42476013 539 IgeNGELLYVADTNNHQIKVMDLETKMV 566
Cdd:cd14963 109 I--DDGKLYVSDVKKHKVIVFDLEGKLL 134
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
216-366 |
7.16e-09 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 57.66 E-value: 7.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 216 DSLPPSPLLFPGKVTVDQvTDRLVIADTGHHRILVVWKNGQIQYSIGGPNPGrkDGifsesTFNSPQGVAIMNN-IIYVA 294
Cdd:cd14957 151 GGTGPGQFNGPQGIAVDS-DGNIYVADTGNHRIQVFTSSGTFQYTFGSSGSG--PG-----QFSDPYGIAVDSDgNIYVA 222
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42476013 295 DTENHLIrkidleaeKVSTVAG-----IGIQGTDKEGgakgeqqpISSPWDVvfgtsgsEVQRGDILWIAMAGTHQI 366
Cdd:cd14957 223 DTGNHRI--------QVFTSSGayqysIGTSGSGNGQ--------FNYPYGI-------AVDNDGKIYVADSNNNRI 276
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
225-436 |
1.13e-08 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 56.91 E-value: 1.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 225 FPGKVTVDqVTDRLVIADTGHHRILVVWKNGQIQYSIGGPN--PGRkdgifsestFNSPQGVAIM-NNIIYVADTENHLI 301
Cdd:cd14956 108 APRGVAVD-ADGNLYVADFGNQRIQKFDPDGSFLRQWGGTGiePGS---------FNYPRGVAVDpDGTLYVADTYNDRI 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 302 RKIDLEAEKVSTVAGigiqgtdkEGGAKGEqqpISSPWDVVFGTSGSevqrgdiLWIAMAGTHQIWALLLDsgklpkkne 381
Cdd:cd14956 178 QVFDNDGAFLRKWGG--------RGTGPGQ---FNYPYGIAIDPDGN-------VFVADFGNNRIQKFTAD--------- 230
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 42476013 382 ltkGTCLRFAGSgneenrnnaYPHKAG-FAQPSGLSLASeDPWscLFVADSESSTV 436
Cdd:cd14956 231 ---GTFLTSWGS---------PGTGPGqFKNPWGVVVDA-DGT--VYVADSNNNRV 271
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
229-315 |
1.54e-08 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 57.20 E-value: 1.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 229 VTVDQvTDRLVIADTGHHRILVV-WKNGQIQYSIGGPNPGRKDgifSESTFNSPQGVAIMNN-IIYVADTENHLIRKIDL 306
Cdd:cd14951 201 VAALP-DGSVYVADTYNHKIKRVdPATGEVSTLAGTGKAGYKD---LEAQFSEPSGLVVDGDgRLYVADTNNHRIRRLDL 276
|
90
....*....|.
gi 42476013 307 EAE--KVSTVA 315
Cdd:cd14951 277 PTEalEVLTLA 287
|
|
| NHL_TRIM71_like |
cd14954 |
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ... |
229-582 |
1.82e-08 |
|
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 56.40 E-value: 1.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 229 VTVDQvTDRLVIADTGHHRILVVWKNGQIQYSIGGPnpGRKDGifsesTFNSPQGVAI-MNNIIYVADTENHLIRKIDLE 307
Cdd:cd14954 29 VAVDK-DGRIIVADRSNNRVQVFDPDGKFLRKFGSY--GSRDG-----QFDRPAGVAVnSRGRIIVADKDNHRIQVFDLN 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 308 aekvstvagigiqgtdkeggakgeqqpisspwdvvfgtsgsevqrgdilwiamagthqiwallldsgklpkkneltkGTC 387
Cdd:cd14954 101 -----------------------------------------------------------------------------GRF 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 388 LR-FAGSGNEENRnnayphkagFAQPSGLSLASEDpwsCLFVADSESSTVRTVSLkDGAVKHLVGGErdpmnlfafGDVD 466
Cdd:cd14954 104 LLkFGERGTKNGQ---------FNYPWGVAVDSEG---RIYVSDTRNHRVQVFDS-DGQFIRKFGFE---------GAGP 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 467 GvginaKLQHPLGVTWDKKRNLlYVADSYNHKIKVVDPktkNCTTLAGTGdtnnvtSSSFTESTFNEPGGLCIGENGELL 546
Cdd:cd14954 162 G-----QLDSPRGVAVNPDGNI-VVSDFNNHRLQVFDP---DGQFLRFFG------SEGSGNGQFKRPRGVAVDDEGNII 226
|
330 340 350
....*....|....*....|....*....|....*.
gi 42476013 547 yVADTNNHQIKVMDLETKMVSVLPIFRSENAVVDGP 582
Cdd:cd14954 227 -VADSGNHRVQVFSPDGEFLCSFGTEGNGEGQFDRP 261
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
460-560 |
2.24e-08 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 56.12 E-value: 2.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 460 FAFGDVdGVGINAkLQHPLGVTWDKKRNLlYVADSYNHKIKVVDPKTKNCTTLaGTGDTNNvtsssfteSTFNEPGGLCI 539
Cdd:cd14957 5 YAFGSN-GSGNGQ-FNTPRGIAVDSAGNI-YVADTGNNRIQVFTSSGVYSYSI-GSGGTGS--------GQFNSPYGIAV 72
|
90 100
....*....|....*....|.
gi 42476013 540 GENGElLYVADTNNHQIKVMD 560
Cdd:cd14957 73 DSNGN-IYVADTDNNRIQVFN 92
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
489-560 |
4.58e-08 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 54.96 E-value: 4.58e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42476013 489 LYVADSYNHKIKVVDPKTKNCTTLAGTGDTNNvtsssftesTFNEPGGLCIGENGElLYVADTNNHQIKVMD 560
Cdd:cd14957 78 IYVADTDNNRIQVFNSSGVYQYSIGTGGSGDG---------QFNGPYGIAVDSNGN-IYVADTGNHRIQVFT 139
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
471-570 |
5.74e-08 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 54.60 E-value: 5.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 471 NAKLQHPLGVTWDKKRnlLYVADSYNHKIKVVDPKTKNCTTLAGTGDtnnvtsssfTESTFNEPGGLCIGENGElLYVAD 550
Cdd:cd14963 6 GDPLNKPMGVAVSDGR--IYVADTNNHRVQVFDYEGKFKKSFGGPGT---------GPGEFKYPYGIAVDSDGN-IYVAD 73
|
90 100
....*....|....*....|
gi 42476013 551 TNNHQIKVMDLETKMVSVLP 570
Cdd:cd14963 74 LYNGRIQVFDPDGKFLKYFP 93
|
|
| NHL_TRIM71_like |
cd14954 |
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ... |
223-301 |
5.77e-08 |
|
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 54.86 E-value: 5.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 223 LLFPGKVTVDQvTDRLVIADTGHHRILVVWKNGQIQYSIGGPNPGrkdgifsESTFNSPQGVAIMNN-IIYVADTENHLI 301
Cdd:cd14954 211 FKRPRGVAVDD-EGNIIVADSGNHRVQVFSPDGEFLCSFGTEGNG-------EGQFDRPSGVAVTPDgRIVVVDRGNHRI 282
|
|
| NHL_like_6 |
cd14962 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
226-307 |
1.23e-07 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 53.75 E-value: 1.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 226 PGKVTVDQVTDRLVIADTGHHRILVVWKNGQIQYSIGgpNPGRKDGifsesTFNSPQGVAIMNN-IIYVADTENHLIRKI 304
Cdd:cd14962 102 PTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIG--KRGSGPG-----EFNLPTDLAVDRDgNLYVTDTMNFRVQIF 174
|
...
gi 42476013 305 DLE 307
Cdd:cd14962 175 DAD 177
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
403-576 |
2.04e-07 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 53.10 E-value: 2.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 403 YPHKAGFAQPSGLSLaseDPWSCLFVADSESSTVRTVSLKDGAVKHLVGGErdpmnlfafgdvdgvginakLQHPLGVTW 482
Cdd:COG4257 10 YPVPAPGSGPRDVAV---DPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGG--------------------GSGPHGIAV 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 483 DKkRNLLYVADSYNHKIKVVDPKTKNCTTLAGTGDTNNvtsssftestfnePGGLCIGENGElLYVADTNNHQIKVMDLE 562
Cdd:COG4257 67 DP-DGNLWFTDNGNNRIGRIDPKTGEITTFALPGGGSN-------------PHGIAFDPDGN-LWFTDQGGNRIGRLDPA 131
|
170
....*....|....
gi 42476013 563 TKMVSVLPIFRSEN 576
Cdd:COG4257 132 TGEVTEFPLPTGGA 145
|
|
| NHL_TRIM71_like |
cd14954 |
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ... |
223-323 |
2.41e-07 |
|
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 52.94 E-value: 2.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 223 LLFPGKVTVDQvTDRLVIADTGHHRILVVWKNGQIQYSIGGPNPGRKDgifsestFNSPQGVAIMN-NIIYVADTENHLI 301
Cdd:cd14954 117 FNYPWGVAVDS-EGRIYVSDTRNHRVQVFDSDGQFIRKFGFEGAGPGQ-------LDSPRGVAVNPdGNIVVSDFNNHRL 188
|
90 100
....*....|....*....|..
gi 42476013 302 RKIDLEAEKVSTvagIGIQGTD 323
Cdd:cd14954 189 QVFDPDGQFLRF---FGSEGSG 207
|
|
| NHL_like_6 |
cd14962 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
216-558 |
3.53e-07 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 52.20 E-value: 3.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 216 DSLPPSPLLFPGKVTVDQvTDRLVIADTGHHRILVVWKNGQIQYSIGGPNPGRkdgifsestFNSPQGVAI-MNNIIYVA 294
Cdd:cd14962 4 EERPKEALTRPYGVAADG-RGRIYVADTGRGAVFVFDLPNGKVFVIGNAGPNR---------FVSPIGVAIdANGNLYVS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 295 DTENHLIRKIDLEAEKVSTVagigiqgtdkeGGAKGEQQPISSPWDvvfgtsgsevQRGDILWIAMAGTHQIWALLLDsG 374
Cdd:cd14962 74 DAELGKVFVFDRDGKFLRAI-----------GAGALFKRPTGIAVD----------PAGKRLYVVDTLAHKVKVFDLD-G 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 375 KLPKkneltkgtclRF--AGSGNEEnrnnayphkagFAQPSGLSLASEDPwscLFVADSESSTVRTVSLKDGAVKHLvgG 452
Cdd:cd14962 132 RLLF----------DIgkRGSGPGE-----------FNLPTDLAVDRDGN---LYVTDTMNFRVQIFDADGKFLRSF--G 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 453 ERdpmnlfafGDVDGvginaKLQHPLGVTWDKKRNLlYVADSYNHKIKVVDPKTKNCTTLAGTGDtnnvtsssfTESTFN 532
Cdd:cd14962 186 ER--------GDGPG-----SFARPKGIAVDSEGNI-YVVDAAFDNVQIFNPEGELLLTVGGPGS---------GPGEFY 242
|
330 340
....*....|....*....|....*.
gi 42476013 533 EPGGLCIGENGElLYVADTNNHQIKV 558
Cdd:cd14962 243 LPSGIAIDKDDR-IYVVDQFNRRIQV 267
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
216-370 |
3.97e-07 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 51.62 E-value: 3.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 216 DSLPPSPLLFPGKVTVDQVTDRLVIADTGHHRILVVW-KNGQIQYSIggpnpgrkdgifseSTFNSPQGVAIM--NNIIY 292
Cdd:COG3391 60 LGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDlATGKVVATI--------------PVGGGPRGLAVDpdGGRLY 125
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42476013 293 VADTENHLIRKIDLEAEKVSTVAGIGiqgtdkeggakgeqqpiSSPWDVVFGTSGSEvqrgdiLWIAMAGTHQIWALL 370
Cdd:COG3391 126 VADSGNGRVSVIDTATGKVVATIPVG-----------------AGPHGIAVDPDGKR------LYVANSGSNTVSVIV 180
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
426-570 |
5.04e-07 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 51.62 E-value: 5.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 426 LFVADSESSTVRTVSLKDGAVKHLVGGERDPMNLFAFGDVDGVGINAKLQHPLGVTWDKKRNLLYVADSYNHKIKVVDPK 505
Cdd:COG3391 19 AALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLA 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42476013 506 TKNCTTLAGTGDtnnvtsssftestfnEPGGLCIGENGELLYVADTNNHQIKVMDLET-KMVSVLP 570
Cdd:COG3391 99 TGKVVATIPVGG---------------GPRGLAVDPDGGRLYVADSGNGRVSVIDTATgKVVATIP 149
|
|
| NHL_like_4 |
cd14955 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
278-556 |
1.73e-06 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 50.27 E-value: 1.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 278 FNSPQGVAI--MNNIiYVADTENHLIRKIDleaekvST---VAGIGIQGTdkeggakGEQQpISSPWDVVFGTSGSevqr 352
Cdd:cd14955 15 FNSPSGIAVdsAGNV-YVADTGNNRIQKFD------STgtfLTKWGSSGS-------GDGQ-FYSPTGIAVDSDGN---- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 353 gdiLWIAMAGTHQIWALllDS-GKLpkkneLTK-GTClrfaGSGNEEnrnnayphkagFAQPSGLSLaseDPWSCLFVAD 430
Cdd:cd14955 76 ---VYVADTGNHRIQKF--DStGTF-----LTKwGSS----GSGDGQ-----------FNSPSGIAV---DSAGNVYVTD 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 431 SESSTVRTVSlKDGAVKHLVGGerdpmnlfaFGDVDGvginaKLQHPLGVTWDKKRNLlYVADSYNHKIKVVDPkTKNCT 510
Cdd:cd14955 128 SGNNRIQKFD-SSGTFITKWGS---------FGSGDG-----QFNSPTGIAVDSAGNV-YVADTGNNRIQKFTS-TGTFL 190
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 42476013 511 TLAGTGDTNNvtsssfteSTFNEPGGLCIGENGeLLYVADTNNHQI 556
Cdd:cd14955 191 TKWGSEGSGD--------GQFNAPYGIAVDSAG-NVYVADTGNNRI 227
|
|
| NHL_brat_like |
cd14959 |
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ... |
531-567 |
5.19e-06 |
|
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271329 [Multi-domain] Cd Length: 274 Bit Score: 48.81 E-value: 5.19e-06
10 20 30
....*....|....*....|....*....|....*..
gi 42476013 531 FNEPGGLCIGENGELLyVADTNNHQIKVMDLETKMVS 567
Cdd:cd14959 21 FNSPSGFCLGEDEDIL-VADTNNHRIQVFDKEGEFKF 56
|
|
| NHL_TRIM71_like |
cd14954 |
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ... |
220-301 |
5.84e-06 |
|
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 48.70 E-value: 5.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 220 PSPLLFPGKVTVDQvTDRLVIADTGHHRILVVWKNGQIQYSIG--GPNPGRkdgifsestFNSPQGVAI--MNNIIyVAD 295
Cdd:cd14954 161 PGQLDSPRGVAVNP-DGNIVVSDFNNHRLQVFDPDGQFLRFFGseGSGNGQ---------FKRPRGVAVddEGNII-VAD 229
|
....*.
gi 42476013 296 TENHLI 301
Cdd:cd14954 230 SGNHRV 235
|
|
| NHL_TRIM2_like |
cd14960 |
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ... |
247-558 |
8.94e-06 |
|
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271330 [Multi-domain] Cd Length: 274 Bit Score: 48.11 E-value: 8.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 247 RILVVWKNGQ-IQ-YSIGGPNPgRKDGIF--SESTFNSPQGVAI-MNNIIYVADTENHLIRKIDLEAEKVSTVagigiqG 321
Cdd:cd14960 29 RLVIADSNNQcVQvFSNDGQFK-LRFGVRgrSPGQLQRPTGVAVtLNGDIIIADYDNKWVSIFSPDGKFKSKI------G 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 322 TDKEGGAKGeqqpisspwdvvfgtsgSEVQR-GDILWIAM-AGTHQIWALlldSGKLpkkneLTkgtclRFAGSGNEENR 399
Cdd:cd14960 102 AGKLMGPKG-----------------VAVDRnGHIIVVDNkACCVFIFQP---NGKL-----VT-----RFGSRGNGDRQ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 400 nnayphkagFAQPSGLSLASEDPwscLFVADSESSTVRtVSLKDGAVkhlvggerdpmnLFAFGdVDGVGiNAKLQHPLG 479
Cdd:cd14960 152 ---------FAGPHFAAVNNNNE---IIVTDFHNHSVK-VFNAEGEF------------LFKFG-SNGEG-NGQFNAPTG 204
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42476013 480 VTWDKKRNLLyVADSYNHKIKVVDpktkncttlaGTGDTNNVTSSSFteSTFNEPGGLCIGENGELLyVADTNNHQIKV 558
Cdd:cd14960 205 VAVDSNGNII-VADWGNSRIQVFD----------SSGSFLSYINTSA--DPLYGPQGLALTSDGHVV-VADSGNHCFKV 269
|
|
| NHL_like_4 |
cd14955 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
471-560 |
1.17e-05 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 47.57 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 471 NAKLQHPLGVTWDKKRNLlYVADSYNHKIKVVDPKTKNCTTLAGTGDTNNvtsssftesTFNEPGGLCIGENGELlYVAD 550
Cdd:cd14955 59 DGQFYSPTGIAVDSDGNV-YVADTGNHRIQKFDSTGTFLTKWGSSGSGDG---------QFNSPSGIAVDSAGNV-YVTD 127
|
90
....*....|
gi 42476013 551 TNNHQIKVMD 560
Cdd:cd14955 128 SGNNRIQKFD 137
|
|
| NHL_TRIM71_like |
cd14954 |
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ... |
459-562 |
4.42e-05 |
|
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 46.00 E-value: 4.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 459 LFAFGDvDGVGiNAKLQHPLGVTWDKKrNLLYVADSYNHKIKVVDPKTKNCTTLAGTGDTNnvtsssfteSTFNEPGGLC 538
Cdd:cd14954 10 LLSFGK-EGSK-DGELCRPWGVAVDKD-GRIIVADRSNNRVQVFDPDGKFLRKFGSYGSRD---------GQFDRPAGVA 77
|
90 100
....*....|....*....|....
gi 42476013 539 IGENGELlYVADTNNHQIKVMDLE 562
Cdd:cd14954 78 VNSRGRI-IVADKDNHRIQVFDLN 100
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
225-304 |
6.21e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 45.35 E-value: 6.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 225 FPGKVTVDQVtDRLVIADTGHHRILVVWKNGQIQYSIGGPnpGRKDGifsesTFNSPQGVAI-MNNIIYVADTENHLIRK 303
Cdd:cd14956 202 YPYGIAIDPD-GNVFVADFGNNRIQKFTADGTFLTSWGSP--GTGPG-----QFKNPWGVVVdADGTVYVADSNNNRVQR 273
|
.
gi 42476013 304 I 304
Cdd:cd14956 274 F 274
|
|
| NHL |
pfam01436 |
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ... |
531-558 |
1.19e-04 |
|
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.
Pssm-ID: 396153 [Multi-domain] Cd Length: 28 Bit Score: 39.69 E-value: 1.19e-04
10 20
....*....|....*....|....*...
gi 42476013 531 FNEPGGLCIGENGELlYVADTNNHQIKV 558
Cdd:pfam01436 1 FNRPHGVAVDSNGDI-YVADSENHRVQV 27
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
472-581 |
2.26e-04 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 43.47 E-value: 2.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 472 AKLQHPLGVTWDKKRNLlYVADSYNHKIKVVDPKTKNCTTlagtgdtnnvtsssFTESTFNEPGGLCIGENGELlYVADT 551
Cdd:COG4257 14 APGSGPRDVAVDPDGAV-WFTDQGGGRIGRLDPATGEFTE--------------YPLGGGSGPHGIAVDPDGNL-WFTDN 77
|
90 100 110
....*....|....*....|....*....|....
gi 42476013 552 NNHQIKVMDLETKMVSVLPIFRSENA----VVDG 581
Cdd:COG4257 78 GNNRIGRIDPKTGEITTFALPGGGSNphgiAFDP 111
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
420-561 |
2.31e-04 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 43.73 E-value: 2.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 420 EDP-WS---CLFVADSESSTVRTVSLKDGAVKHLVGGERdpmnlfafgdvdgvginaklqHPLGVTWDKKRNlLYVADSy 495
Cdd:COG3386 11 EGPvWDpdgRLYWVDIPGGRIHRYDPDGGAVEVFAEPSG---------------------RPNGLAFDPDGR-LLVADH- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 496 NHKIKVVDPKTKNCTTLAGTGDT-----NNVTSSS-----FTESTFNEPG-----------------------GLCIGEN 542
Cdd:COG3386 68 GRGLVRFDPADGEVTVLADEYGKplnrpNDGVVDPdgrlyFTDMGEYLPTgalyrvdpdgslrvladgltfpnGIAFSPD 147
|
170
....*....|....*....
gi 42476013 543 GELLYVADTNNHQIKVMDL 561
Cdd:COG3386 148 GRTLYVADTGAGRIYRFDL 166
|
|
| NHL_like_4 |
cd14955 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
225-367 |
3.13e-04 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 43.33 E-value: 3.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 225 FPGKVTVDQvTDRLVIADTGHHRILVVWKNGQIQYSIGGPnpGRKDGifsesTFNSPQGVAI--MNNIiYVADTENHLIR 302
Cdd:cd14955 158 SPTGIAVDS-AGNVYVADTGNNRIQKFTSTGTFLTKWGSE--GSGDG-----QFNAPYGIAVdsAGNV-YVADTGNNRIQ 228
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42476013 303 KIDLEAEKVSTVAGigiqgtdkEGGAKGEqqpISSPWDVVFGTSGSevqrgdiLWIAMAGTHQIW 367
Cdd:cd14955 229 KFDSSGTFITKWGS--------EGSGDGQ---FNSPSGIAVDSAGN-------VYVADSGNNRIQ 275
|
|
| NHL_like_4 |
cd14955 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
225-305 |
4.55e-04 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 42.95 E-value: 4.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 225 FPGKVTVDQVTDRLViADTGHHRILVVWKNGQIQYSIGgpNPGRKDGifsesTFNSPQGVAI-MNNIIYVADTENHLIRK 303
Cdd:cd14955 205 APYGIAVDSAGNVYV-ADTGNNRIQKFDSSGTFITKWG--SEGSGDG-----QFNSPSGIAVdSAGNVYVADSGNNRIQK 276
|
..
gi 42476013 304 ID 305
Cdd:cd14955 277 FA 278
|
|
| NHL_PAL_like |
cd14958 |
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ... |
409-564 |
6.91e-04 |
|
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271328 [Multi-domain] Cd Length: 300 Bit Score: 42.25 E-value: 6.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 409 FAQPSGLSLASEDPwscLFVADSESSTVRTVSLkDGAVKHLVG-GER----DPMNLFAfgdvdgvginaklqHPLGVTWD 483
Cdd:cd14958 75 FYMPHGLTIDPDGN---IWVTDVGLHQVFKFDP-EGKLLPLLTlGERgepgSDQTHFC--------------KPTDVAVA 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 484 KKRNLlYVADSY-NHKIKVVDPktkncttlagtgDTNNVTS---SSFTESTFNEPGGLCIGENGeLLYVADTNNHQIKVM 559
Cdd:cd14958 137 PDGDI-FVADGYcNSRIVKFSP------------DGKLLKSwgePGSGPGQFNLPHSIALDEDG-RVYVADRENGRIQVF 202
|
....*
gi 42476013 560 DLETK 564
Cdd:cd14958 203 DADGK 207
|
|
| NHL |
pfam01436 |
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ... |
278-303 |
8.28e-04 |
|
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.
Pssm-ID: 396153 [Multi-domain] Cd Length: 28 Bit Score: 37.00 E-value: 8.28e-04
10 20
....*....|....*....|....*..
gi 42476013 278 FNSPQGVAIM-NNIIYVADTENHLIRK 303
Cdd:pfam01436 1 FNRPHGVAVDsNGDIYVADSENHRVQV 27
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
472-569 |
1.31e-03 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 41.42 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 472 AKLQHPLGVTWDKKRNLlYVADSYNHKIKVVDPKTKNCTTLAGTGdtnnvtsssftestfNEPGGLCIGENGElLYVADT 551
Cdd:COG3386 5 AGFRLGEGPVWDPDGRL-YWVDIPGGRIHRYDPDGGAVEVFAEPS---------------GRPNGLAFDPDGR-LLVADH 67
|
90
....*....|....*...
gi 42476013 552 nNHQIKVMDLETKMVSVL 569
Cdd:COG3386 68 -GRGLVRFDPADGEVTVL 84
|
|
| AhpC-TSA |
pfam00578 |
AhpC/TSA family; This family contains proteins related to alkyl hydroperoxide reductase (AhpC) ... |
74-173 |
7.30e-03 |
|
AhpC/TSA family; This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA).
Pssm-ID: 425763 [Multi-domain] Cd Length: 124 Bit Score: 37.20 E-value: 7.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476013 74 KDLCGKIVVLDFF-TYCCINCIHLLPDLHALeHTYSDKDGLLIIGVHSAKfpnekvLDNIKSAVLRYNITHPMVNDADAS 152
Cdd:pfam00578 21 SDYRGKWVVLFFYpADWTPVCTTELPALADL-YEEFKKLGVEVLGVSVDS------PESHKAFAEKYGLPFPLLSDPDGE 93
|
90 100
....*....|....*....|....*..
gi 42476013 153 L------WQELEVSCWPTLVILGPRGN 173
Cdd:pfam00578 94 VaraygvLNEEEGGALRATFVIDPDGK 120
|
|
| |
