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Conserved domains on  [gi|38348402|ref|NP_940965|]
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store-operated calcium entry regulator STIMATE [Homo sapiens]

Protein Classification

STIMATE family protein( domain architecture ID 10574949)

STIMATE family protein similar to human store-operated calcium entry regulator STIMATE, also called transmembrane protein 110 (TMEM110), a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER

Gene Ontology:  GO:0016020
PubMed:  26322679

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
STIMATE pfam12400
STIMATE family; STIMATE is a ER-resident multi-transmembrane protein that serves as a positive ...
 100-219 7.45e-51

STIMATE family; STIMATE is a ER-resident multi-transmembrane protein that serves as a positive regulator of Ca(2+) influx in vertebrates. It interacts with ER-resident Ca2+ sensor protein STIM1 to promote STIM1 conformational switch. This entry also includes budding yeast YPL162C.


:

Pssm-ID: 463561  Cd Length: 124  Bit Score: 163.43  E-value: 7.45e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348402   100 CSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLIL-QW 178
Cdd:pfam12400   1 CSWYFLNILLDTTLGVLILYLLLRLLTKLARRKGIEGIESGNYGKPPSFRAWLKQLLVYLLGLVIMKLVVFLLLLLFpWL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 38348402   179 KKVA--LLNPIE-NPDLKLAIVMLIVPFFVNALMFWVVDNFLMR 219
Cdd:pfam12400  81 FWVGdwLLSWLDgNPKLQLIFVMLIFPLIMNALQFWIIDSIIKK 124
 
Name Accession Description Interval E-value
STIMATE pfam12400
STIMATE family; STIMATE is a ER-resident multi-transmembrane protein that serves as a positive ...
 100-219 7.45e-51

STIMATE family; STIMATE is a ER-resident multi-transmembrane protein that serves as a positive regulator of Ca(2+) influx in vertebrates. It interacts with ER-resident Ca2+ sensor protein STIM1 to promote STIM1 conformational switch. This entry also includes budding yeast YPL162C.


Pssm-ID: 463561  Cd Length: 124  Bit Score: 163.43  E-value: 7.45e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348402   100 CSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLIL-QW 178
Cdd:pfam12400   1 CSWYFLNILLDTTLGVLILYLLLRLLTKLARRKGIEGIESGNYGKPPSFRAWLKQLLVYLLGLVIMKLVVFLLLLLFpWL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 38348402   179 KKVA--LLNPIE-NPDLKLAIVMLIVPFFVNALMFWVVDNFLMR 219
Cdd:pfam12400  81 FWVGdwLLSWLDgNPKLQLIFVMLIFPLIMNALQFWIIDSIIKK 124
 
Name Accession Description Interval E-value
STIMATE pfam12400
STIMATE family; STIMATE is a ER-resident multi-transmembrane protein that serves as a positive ...
 100-219 7.45e-51

STIMATE family; STIMATE is a ER-resident multi-transmembrane protein that serves as a positive regulator of Ca(2+) influx in vertebrates. It interacts with ER-resident Ca2+ sensor protein STIM1 to promote STIM1 conformational switch. This entry also includes budding yeast YPL162C.


Pssm-ID: 463561  Cd Length: 124  Bit Score: 163.43  E-value: 7.45e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348402   100 CSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLIL-QW 178
Cdd:pfam12400   1 CSWYFLNILLDTTLGVLILYLLLRLLTKLARRKGIEGIESGNYGKPPSFRAWLKQLLVYLLGLVIMKLVVFLLLLLFpWL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 38348402   179 KKVA--LLNPIE-NPDLKLAIVMLIVPFFVNALMFWVVDNFLMR 219
Cdd:pfam12400  81 FWVGdwLLSWLDgNPKLQLIFVMLIFPLIMNALQFWIIDSIIKK 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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