|
Name |
Accession |
Description |
Interval |
E-value |
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
60-1009 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1011.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 60 YRDTVLLPQTSFPMKL-LgrqqSDMELEIQQKcgfselysWQRE---------RKVKTEFCLHDGPPYANGDPHVGHALN 129
Cdd:COG0060 1 YKETLNLPKTDFPMRAnL----PKREPEILKF--------WEENdiyeksreaRAGRPKFVLHDGPPYANGDIHIGHALN 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 130 KILKDIANRFHMMRGSKVHFVPGWDCHGLPIETKVLSELGVDAQSLSAM---EIREKARSFAQAAIEKQKSAFVRWGVMA 206
Cdd:COG0060 69 KILKDIIVRYKTMRGFDVPYVPGWDCHGLPIELKVEKELGIKKKDIEKVgiaEFREKCREYALKYVDEQREDFKRLGVWG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 207 DWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKPVYWSPSSRTALAEAELEYnPEHVSRSIYVRFPLLRPPPKLeslt 286
Cdd:COG0060 149 DWDNPYLTMDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEY-KDVTSPSIYVKFPVKDEKALL---- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 287 dASSPVSVLVWTTQPWTIPANQAICYMPEAKYAVVKCsASGHLYILAEDKIAPVASALE-TTFDVVAAFSGVDLEGGTCS 365
Cdd:COG0060 224 -LLEDAYLVIWTTTPWTLPANLAVAVHPDIDYVLVEV-TGGERLILAEALVEAVLKELGiEDYEVLATFKGAELEGLRYE 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 366 HPL----TPDKVSPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEGGMFTDAAgPELQNKAVlKEGTD 441
Cdd:COG0060 302 HPFyyvvGYDRAHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEA-PLFAGLFV-KDANP 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 442 VVIKMLQATKNVLKEENIVHSYPCDWRTKTPVLIRASKQWFVNITDIKAAAKESLKTVKFIPGAALNSMTDMLDRRPYWC 521
Cdd:COG0060 380 AIIEDLKERGALLAREKITHSYPHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPEWGEGRFGNMLENRPDWC 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 522 ISRQRVWGVPIPVFHHKTKDEYLINSQTTEHIIKLVEQHGSDVWWTL-PAEQLLPAEVLAQAGGPgalEYAPGQDILDIW 600
Cdd:COG0060 460 ISRQRYWGVPIPIWVCEDCGELHRTEEVIGSVAELLEEEGADAWFELdLHRPFLDETLKCPKCGG---TMRRVPDVLDVW 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 601 FDSGTSWSCVLQDTQQR---ADLYLEGKDQLGGWFQSSLLTSVATRSKAPFRTVMVHGFTLGEKGEKMSKSLGNVINPDT 677
Cdd:COG0060 537 FDSGSMHFAVLENREELhfpADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQE 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 678 IISggkdhskepPYGADILRWWIAESNVFTEVTIGPSVLSAARDDISKLRNTLRFLLGNLTGFNPETDSVPVKNMYVIDQ 757
Cdd:COG0060 617 VID---------KYGADILRLWVASSDYWGDLRFSDEILKEVRDVYRRLRNTYRFLLANLDDFDPAEDAVPYEDLPELDR 687
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 758 YMLHLIQDFATKITDSYKQYDFGKVVRLLKAFYTRELSSFYFSIVKDRLYCENEKDPKRRSCQTALAEILDVLVRAFAPI 837
Cdd:COG0060 688 WILSRLNELIKEVTEAYDNYDFHRAYRALHNFCVEDLSNWYLDISKDRLYTEAADSLDRRAAQTTLYEVLETLVRLLAPI 767
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 838 LPHLAEEVFQHIPYvTEPKSVFRTGWINTSSIWKKPGLEEAVESACAMRDSFLGSIPGKNAA-------EYEVIIVIEPg 910
Cdd:COG0060 768 LPFTAEEIWQNLPG-EAEESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLKALEAARKEklirqplEAAVVLYADE- 845
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 911 llfEIMEMLQAEEtsstSQLNELMMASQTTLLAQEPRERTAGdieltgtfvinLEGGDIrEESSYKVIVVPTAREKCPRC 990
Cdd:COG0060 846 ---ELAAALESLG----DLLAEELNVSEVELVDDAEDLGKDA-----------LKALDV-EGISVTVEVEKADGEKCERC 906
|
970 980
....*....|....*....|..
gi 38490690 991 WKHT-SETADA--LCPRCAEVI 1009
Cdd:COG0060 907 WHYEvGWTPEHegLCRRCVRRV 928
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
84-1012 |
0e+00 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 949.21 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 84 ELEIQQKCGFSELYSWQRERKVKTEFCLHDGPPYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETK 163
Cdd:PLN02843 9 EPEIQKLWEENQVYKRVSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 164 VLSELGVDA-QSLSAMEIREKARSFAQAAIEKQKSAFVRWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKP 242
Cdd:PLN02843 89 VLQSLDQEArKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRKP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 243 VYWSPSSRTALAEAELEYnPE-HVSRSIYVRFPLLRPPPKLESLTDASSP-VSVLVWTTQPWTIPANQAICYMPEAKYAV 320
Cdd:PLN02843 169 VHWSPSSRTALAEAELEY-PEgHVSKSIYVAFPVVSPSETSPEELEEFLPgLSLAIWTTTPWTMPANAAVAVNDKLQYSV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 321 V------------------------KCSASGHLyILAEDKIAPVASALETTFDVVAAFSGVDLEGGTCSHPLTPDKVSPL 376
Cdd:PLN02843 248 VevqsfsedestsggnkkkrpgnvlKEQQKLFL-IVATDLVPALEAKWGVKLVVLKTFPGSDLEGCRYIHPLYNRESPVV 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 377 LPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEGGMFTDAAGPeLQNKAVLKEGTDVVIKMLQATKNVLKE 456
Cdd:PLN02843 327 IGGDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQ-FSGLSVLGEGNAAVVEALDEAGSLLME 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 457 ENIVHSYPCDWRTKTPVLIRASKQWFVNITDIKAAAKESLKTVKFIPGAALNSMTDMLDRRPYWCISRQRVWGVPIPVFH 536
Cdd:PLN02843 406 EAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPAQGENRIRAMVSGRSDWCISRQRTWGVPIPVFY 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 537 HKTKDEYLINSQTTEHIIKLVEQHGSDVWWTLPAEQLLPAEVLAQAGgpgalEYAPGQDILDIWFDSGTSWSCVLQdtqQ 616
Cdd:PLN02843 486 HVETKEPLMNEETIAHVKSIVAQKGSDAWWYMDVEDLLPEKYRDKAS-----DYEKGTDTMDVWFDSGSSWAGVLG---S 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 617 R------ADLYLEGKDQLGGWFQSSLLTSVATRSKAPFRTVMVHGFTLGEKGEKMSKSLGNVINPDTIISGGKDHSKEPP 690
Cdd:PLN02843 558 ReglsypADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEGGKNQKQEPA 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 691 YGADILRWWIAESNVFTEVTIGPSVLSAARDDISKLRNTLRFLLGNLTGFNPEtDSVPVKNMYVIDQYMLHLIQDFATKI 770
Cdd:PLN02843 638 YGADVLRLWVASVDYTGDVLIGPQILKQMSDIYRKLRGTLRYLLGNLHDWKPD-NAVPYEDLPSIDKYALFQLENVVNEI 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 771 TDSYKQYDFGKVVRLLKAFYTRELSSFYFSIVKDRLYCENEKDPKRRSCQTALAEILDVLVRAFAPILPHLAEEVFQHIP 850
Cdd:PLN02843 717 EESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYVGGTTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAEDAWQNLP 796
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 851 YVTEP---KSVFRTGWINTSSIWKKPGLEEA----------VESACAMRDSFLGSIPGKNAAEYEVIIVIEPGLLFEIME 917
Cdd:PLN02843 797 FQEDGsaaESVFEAGWPTPNEEWLSFPAEDVdfwslllevrDEVNKVLESARNGKLIGASLEAKVYLHASDASLAARLAE 876
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 918 MLQAEetSSTSQLNELMMASQTTLLAQEPRERTAGDIElTGTFVINLEGgdireessykvIVVPTAR---EKCPRCWKHT 994
Cdd:PLN02843 877 LCGAS--NGADELRRIFITSQVEVVSSEDDETAACGSY-TGEYVEGAGR-----------VWVGVSRadgSKCERCWNYS 942
|
970 980
....*....|....*....|...
gi 38490690 995 -----SETADALCPRCAEVIGAK 1012
Cdd:PLN02843 943 pavgsFSDHPTLCERCYPVVIAQ 965
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
70-890 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 845.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 70 SFPMKL-LGRQQSDMELEIQQKCGFSELyswQRERKVKTEFCLHDGPPYANGDPHVGHALNKILKDIANRFHMMRGSKVH 148
Cdd:TIGR00392 1 KFPMRGnLSKREEKILAFWQENDIFEKV---KKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 149 FVPGWDCHGLPIETKVLSELGV----DAQSLSAMEIREKARSFAQAAIEKQKSAFVRWGVMADWNNCYYTFDPKYEAKQL 224
Cdd:TIGR00392 78 RKPGWDTHGLPIEHKVEKKLGIsgkkEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQW 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 225 RVFYQMYEKGLVYRSYKPVYWSPSSRTALAEAELEYN---PEHVSRSIYVRFPLlrpppKLESLTDASSPV-SVLVWTTQ 300
Cdd:TIGR00392 158 WLFKEAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYKenyKDVKDPSIYVKFPV-----KKDKKTYLKVKLsSLLIWTTT 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 301 PWTIPANQAICYMPEAKYAVVKCSASGHLYILAEDKIAPVASALETTFDVVAAFSGVDLEGGTCSHPLtPDKVSPLLP-- 378
Cdd:TIGR00392 233 PWTLPSNLAIAVHPDFEYALVQDNTKVEYFILAKKLVEKLYNKAGSDYEIIKTFKGSDLEGLEYEHPL-YDFVSQLKEga 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 379 -----ATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEGGMFTDAAGPE------LQNKAVLKeGTDVVIKML 447
Cdd:TIGR00392 312 pvvigGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVLSPVDEKGVYTEGVNDFqgrfvkDADKDIIK-ANKIIIEQL 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 448 QATKNVLKEENIVHSYPCDWRTKTPVLIRASKQWFVNITDIKAAAKESLKTVKFIPGAALNSMTDMLDRRPYWCISRQRV 527
Cdd:TIGR00392 391 KDKGLLLKAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWGEGRFGNWLENRPDWCISRQRY 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 528 WGVPIPVFHHKTKDEYlINSQTTEHIIKLVEQHGSDVWWTLPAEQLLPAEVLAQAGGPgalEYAPGQDILDIWFDSGTSW 607
Cdd:TIGR00392 471 WGIPIPIWYCEDTGEP-IVVGSIEELIELIELKGIDAWFEDLHRDFLDKITLKSGDGG---EYRRVPDVLDVWFDSGSMP 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 608 SCVL--------QDTQQRADLYLEGKDQLGGWFQSSLLTSVATRSKAPFRTVMVHGFTLGEKGEKMSKSLGNVINPDTII 679
Cdd:TIGR00392 547 YASIhypfenekFKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVI 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 680 SggkdhskepPYGADILRWWIAESNVFTEVTIGPSVLSAARDDISKLR-NTLRFLL--GNLTGFNPETDSVPVKNMYVID 756
Cdd:TIGR00392 627 N---------KYGADILRLYVASSDPWEDLRFSDEILKQVVEKYRKIRwNTYRFLLtyANLDKFDPLFNSVAVEKFPEED 697
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 757 QYMLHLIQDFATKITDSYKQYDFGKVVRLLKAFYTRELSSFYFSIVKDRLYCENeKDPKRRSCQTALAEILDVLVRAFAP 836
Cdd:TIGR00392 698 RWILSRLNSLVEEVNEALEKYNFHKVLRALQDFIVEELSNWYIRIIRDRLYCEA-KDNDKRAAQTTLYYALLTLVRLLAP 776
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....
gi 38490690 837 ILPHLAEEVFQHIPYVTEPKSVFRTGWINTSSIWKKPGLEEAVESACAMRDSFL 890
Cdd:TIGR00392 777 FLPHTAEEIYQNLPGGEEEESVHLNLWPEVDEEFIDEALEANMAIVREIVEAFL 830
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
103-705 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 554.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 103 RKVKTEFCLHDGPPYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETKVLSELGV----DAQSLSAM 178
Cdd:pfam00133 19 RKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVVEKKLGIkekkTRHKYGRE 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 179 EIREKARSFAQAAIEKQKSAFVRWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKPVYWSPSSRTALAEAEL 258
Cdd:pfam00133 99 EFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTALSNLEV 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 259 EYNpEHVSRSIYVRFPLlrpppklesltDASSPVSVLVWTTQPWTIPANQAICYMPEAKYAVvkcsaSGHLYILAEDKIA 338
Cdd:pfam00133 179 EYK-DVKGPSIHVAFPL-----------ADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYVI-----TGEGYILAEALLK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 339 PVASAlETTFDVVAAFSGVDLEGGTCSHPLTpDKVSPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDE 418
Cdd:pfam00133 242 SLYKK-GTDKKILEDFRGKELEGKEAIHPFV-NREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDD 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 419 GGMFTDAAgPELQNKAVlKEGTDVVIKMLQATKNVLKEENIVHSYPCDWRTKTPVLIRASKQWFVNITDIKAAAKESLKT 498
Cdd:pfam00133 320 DGTFTEEA-PDFQGVYR-FDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQALEAVEK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 499 VKFIPGAALNSMTDMLDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINSQTTEHIIKLVEQHGSDVWWTLPAEQLLPAev 578
Cdd:pfam00133 398 VQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGRFEEEGSIKWLHREAKDKLGY-- 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 579 laqagGPGALEYAPgqDILDIWFDSGTSWSCVLQ---------DTQQRADLYLEGKDQLGGWFQSSLLTSVATRSKAPFR 649
Cdd:pfam00133 476 -----GKGTLEQDE--DVLDTWFSSGSWPFSTLGwpfvnteefKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFK 548
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*.
gi 38490690 650 TVMVHGFTLGEKGEKMSKSLGNVINPDTIISggkdhskepPYGADILRWWIAESNV 705
Cdd:pfam00133 549 NVLVHGLVRDEQGRKMSKSLGNVIDPLDVID---------KYGADALRLWLANSDY 595
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
83-882 |
1.76e-119 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 384.93 E-value: 1.76e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 83 MELEIQQKCGFSELYSWQRERKvKTEFCLHDGPPYANGDPHVGHALNKILKDIANRFHMMRGSKVhFVP-GWDCHGLPIE 161
Cdd:PRK13208 15 LEEKWQKIWEEEGTYKFDPDER-KPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNV-FFPqGWDDNGLPTE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 162 TKVLSELGVDAQSLSAMEIREKARSFAQAAIEKQKSAFVRWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYK 241
Cdd:PRK13208 93 RKVEKYYGIRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKKGLIYRAEA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 242 PVYWSPSSRTALAEAELEYNPEHvSRSIYVRFPLlrppPKLESLTDAsspvsvlvwTTQPWTIPANQAICYMPE-AKYAv 320
Cdd:PRK13208 173 PVLWCPRCETAIAQAEVEYRERE-GKLNYIKFPV----EDGEEIEIA---------TTRPELLPACVAVVVHPDdERYK- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 321 vkcsasghlyilaedkiapvasalettfdvvaafsgvDLEGGTCSHPLTPDKVsPLLPATHVTMAKGTGLVhtapahgM- 399
Cdd:PRK13208 238 -------------------------------------HLVGKTAIVPLFGVEV-PILADPLVDPDFGTGAV-------Mi 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 400 ------EDYSVASQHSLPMDCLVDEGGMFTDAAGpELQNKAVlKEGTDVVIKMLQATKNVLKEENIVHSYPCDWRTKTPV 473
Cdd:PRK13208 273 ctfgdkTDVTWWRELNLPTRIIIDEDGRMTEAAG-KLAGLTI-EEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPL 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 474 LIRASKQWFVNITDIKAAAKESLKTVKFIPGaalnsmtDMLDRrpY----------WCISRQRVWGVPIPVFHHKTKDey 543
Cdd:PRK13208 351 EILVTRQWFIKVLDLKEELLERGKEINWYPE-------HMRVR--LenwieglnwdWCISRQRYFGTPIPVWYCKDCG-- 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 544 linsqtteHIIklveqhgsdvwwtLPAEQLLPAEVLAQAggP--------GALEYAPGQDILDIWFDSGTSWSCV----- 610
Cdd:PRK13208 420 --------HPI-------------LPDEEDLPVDPTKDE--PpgykcpqcGSPGFEGETDVMDTWATSSITPLIVtgwer 476
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 611 ---LQDTQQRADLYLEGKDQLGGWFQSSLLTSVATRSKAPFRTVMVHGFTLGEKGEKMSKSLGNVINPDTIIsggkdhsk 687
Cdd:PRK13208 477 dedLFEKVFPMDLRPQGHDIIRTWLFYTILRAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELL-------- 548
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 688 ePPYGADILRWWIAESNVFTEVTIGPSVLSAARDDISKLRNTLRFLLgnltGFNPETDSVPVKNMYVIDQYMLHLIQDFA 767
Cdd:PRK13208 549 -EKYGADAVRYWAASARLGSDTPFDEKQVKIGRRLLTKLWNASRFVL----HFSADPEPDKAEVLEPLDRWILAKLAKVV 623
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 768 TKITDSYKQYDFGKVVRLLKAFYTRELSSFYFSIVKDRLYCENEKDPkRRSCQTALAEILDVLVRAFAPILPHLAEEVFQ 847
Cdd:PRK13208 624 EKATEALENYDFAKALEEIESFFWHVFCDDYLELVKSRAYGEDEEEE-QKSARYTLYTVLDTLLRLLAPFLPFITEEVWS 702
|
810 820 830
....*....|....*....|....*....|....*
gi 38490690 848 HIpyvtEPKSVFRTGWINTSSIWKKPGLEEAVESA 882
Cdd:PRK13208 703 WL----YGGSVHRASWPEPDEELIDEEDEELGELA 733
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
81-850 |
4.91e-115 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 374.78 E-value: 4.91e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 81 SDMELEIQQKCGFSELYSWQrERKVKTEFCLHDGPPYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPI 160
Cdd:TIGR00422 8 HEVEKKWYKKWEKSGFFKPD-GNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAGIAT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 161 ETKVLSELGVDAQS---LSAMEIREKARSFAQAAIEKQKSAFVRWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVY 237
Cdd:TIGR00422 87 QVKVEKKLGAEGKTkhdLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYEKGLIY 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 238 RSYKPVYWSPSSRTALAEAELEYNPehVSRSI-YVRFPLlrpppklesltDASSPVSVLVWTTQPWTIPANQAICYMPEA 316
Cdd:TIGR00422 167 RGEYLVNWDPKLNTAISDIEVEYKE--VKGKLyYIRYPL-----------ANGSKDYLVVATTRPETMFGDTAVAVHPED 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 317 K-YAvvkcsasghlyilaedkiapvasalettfdvvaafsgvDLEGGTCSHPLTPDKVsPLLPATHVTMAKGTGLVHTAP 395
Cdd:TIGR00422 234 ErYK--------------------------------------HLIGKKVILPLTGRKI-PIIADEYVDMEFGTGAVKVTP 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 396 AHGMEDYSVASQHSLPMDCLVDEGGMFTDAAGpELQNKAVLkEGTDVVIKMLQATKNVLKEENIVHSYPCDWRTKTPVLI 475
Cdd:TIGR00422 275 AHDFNDYEWGKRHNLEFINILDEDGLLNENAG-KYQGLTRF-EARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEP 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 476 RASKQWFVNITDIKAAAKESLK--TVKFIPG----AALNSMTDMLDrrpyWCISRQRVWGVPIPVFHHKtkdeylinsQT 549
Cdd:TIGR00422 353 LLSKQWFVKVEKLADKALEAAEegEIKFVPKrmekRYLNWLRNIKD----WCISRQLIWGHRIPVWYCK---------EC 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 550 TEHIIKLVEqhgsdvwwtlpaeqllpAEVLAQAGGPGALEYAPGQDILDIWFDSG-TSWSCV--LQDTQQRADLY----- 621
Cdd:TIGR00422 420 GEVYVAKEE-----------------PLPDDKTNTGPSVELEQDTDVLDTWFSSSlWPFSTLgwPDETKDLKKFYptdll 482
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 622 LEGKDQLGGWFQSSLLTSVATRSKAPFRTVMVHGFTLGEKGEKMSKSLGNVINPDTIISggkdhskepPYGADILRWWIA 701
Cdd:TIGR00422 483 VTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIE---------KYGADALRFTLA 553
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 702 esnvfTEVTIGPSV------LSAARDDISKLRNTLRFLLGNLTgfNPETDSVPVKNMYVIDQYMLHLIQDFATKITDSYK 775
Cdd:TIGR00422 554 -----SLVTPGDDInfdwkrVESARNFLNKLWNASRFVLMNLS--DDLELSGGEEKLSLADRWILSKLNRTIKEVRKALD 626
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38490690 776 QYDFGKVVRLLKAFYTRELSSFYFSIVKDRLYCENEKdpKRRSCQTALAEILDVLVRAFAPILPHLAEEVFQHIP 850
Cdd:TIGR00422 627 KYRFAEAAKALYEFIWNDFCDWYIELVKYRLYNGNEA--EKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFK 699
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
106-857 |
5.16e-95 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 326.68 E-value: 5.16e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 106 KTEFCLHDGPPYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETKVLSELGV----DAQSLSAMEIR 181
Cdd:PLN02882 37 LPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPVEYEIDKKLGIkrrdDVLKMGIDKYN 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 182 EKARSFAQAAIEKQKSAFVRWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKPVYWSPSSRTALAEAELEYN 261
Cdd:PLN02882 117 EECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAGLN 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 262 PEHVSR-SIYVRFPLLrpppklesltDASSPVSVLVWTTQPWTIPANQAICYMPEAKYAVVKCSASGHLYILAEDKIAPV 340
Cdd:PLN02882 197 YKDVSDpAVMVSFPIV----------GDPDNASFVAWTTTPWTLPSNLALCVNPNFTYVKVRNKYTGKVYIVAESRLSAL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 341 ASA------------LETTFDVVAAFSGVDLEGgtcshpltpDKVSPLLP--------------ATHVTMAKGTGLVHTA 394
Cdd:PLN02882 267 PTAkpkskkgskpenAAEGYEVLAKVPGSSLVG---------KKYEPLFDyfsefsdtafrvvaDDYVTDDSGTGVVHCA 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 395 PAHGMEDYSVASQH-------SLPmdCLVDEGGMFTDAAgPELQNKAVlKEGTDVVIKMLQATKNVLKEENIVHSYPCDW 467
Cdd:PLN02882 338 PAFGEDDYRVCLANgiiekggNLP--VPVDDDGCFTEKV-TDFSGRYV-KDADKDIIAAIKAKGRLVKSGSITHSYPFCW 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 468 RTKTPVLIRASKQWFVNITDIKAAAKESLKTVKFIPGAAL-----NSMTDMLDrrpyWCISRQRVWGVPIPVFHHKTKDE 542
Cdd:PLN02882 414 RSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKekrfhNWLENARD----WAVSRSRFWGTPLPIWISDDGEE 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 543 YL-INSqttehIIKLVEQHGSDVW---------WTLPAEQllpaevlaqagGPGALEYAPGQDILDIWFDSGTswscvLQ 612
Cdd:PLN02882 490 VVvIGS-----IAELEKLSGVKVTdlhrhfidhITIPSSR-----------GPEFGVLRRVDDVFDCWFESGS-----MP 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 613 DTQQR--------------ADLYLEGKDQLGGWFQSSLLTSVATRSKAPFRTVMVHGFTLGEKGEKMSKSLGNVINPDTI 678
Cdd:PLN02882 549 YAYIHypfenkelfeknfpADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEV 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 679 ISggkdhskepPYGADILRWWI-------AESNVFTEvtigPSVLSAARDDISKLRNTLRFLLGN--------LTGFNPE 743
Cdd:PLN02882 629 ID---------KYGADALRLYLinspvvrAEPLRFKE----EGVFGVVKDVFLPWYNAYRFLVQNakrlevegGAPFVPL 695
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 744 TDSVPVKNMYVIDQYMLHLIQD---FATKITDSYKQYDFgkVVRLLKafYTRELSSFYFSIVKDRLY-CENEKDpkrrsC 819
Cdd:PLN02882 696 DLAKLQNSANVLDRWINSATQSlvkFVREEMGAYRLYTV--VPYLVK--FIDNLTNIYVRFNRKRLKgRTGEED-----C 766
|
810 820 830 840
....*....|....*....|....*....|....*....|.
gi 38490690 820 QTALAEILDVLV---RAFAPILPHLAEEVFQHIPYVTEPKS 857
Cdd:PLN02882 767 RTALSTLYNVLLtscKVMAPFTPFFTEVLYQNLRKVLPGSE 807
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
711-890 |
4.03e-79 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 255.53 E-value: 4.03e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 711 IGPSVLSAARDDISKLRNTLRFLLGNLTGFNPETDSVPVKNMYVIDQYMLHLIQDFATKITDSYKQYDFGKVVRLLKAFY 790
Cdd:cd07960 1 ISDEILKQVAEAYRKIRNTFRFLLGNLNDFDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 791 TRELSSFYFSIVKDRLYCENEKDPKRRSCQTALAEILDVLVRAFAPILPHLAEEVFQHIPYVTEPKSVFRTGWINTSSIW 870
Cdd:cd07960 81 TVDLSAFYLDIIKDRLYCDAKDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGEKKEESVFLEDWPELPEEW 160
|
170 180
....*....|....*....|
gi 38490690 871 KKPGLEEAVESACAMRDSFL 890
Cdd:cd07960 161 KDEELEEKWEKLLALRDEVN 180
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
472-708 |
1.40e-77 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 257.55 E-value: 1.40e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 472 PVLIRASKQWFVNITDIKAAAKESLKTVKFIPGAALNSMTDMLDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINsqtte 551
Cdd:cd00818 144 PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVLVR----- 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 552 hiiklveqhgsdvwwtlpaeqllpaevlaqaggpgaleyaPGQDILDIWFDSGTSWSCVL--------QDTQQRADLYLE 623
Cdd:cd00818 219 ----------------------------------------RVPDVLDVWFDSGSMPYAQLhypfenedFEELFPADFILE 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 624 GKDQLGGWFQSSLLTSVATRSKAPFRTVMVHGFTLGEKGEKMSKSLGNVINPDTIIsggkdhskePPYGADILRWWIAES 703
Cdd:cd00818 259 GSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVV---------DKYGADALRLWVASS 329
|
....*
gi 38490690 704 NVFTE 708
Cdd:cd00818 330 DVYAE 334
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
107-245 |
2.78e-75 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 251.38 E-value: 2.78e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 107 TEFCLHDGPPYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETKVLSELGV----DAQSLSAMEIRE 182
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGIsgkkDIEKMGIAEFNA 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38490690 183 KARSFAQAAIEKQKSAFVRWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKPVYW 245
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW 143
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
104-849 |
3.05e-74 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 267.22 E-value: 3.05e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 104 KVKTEFCLHDGPPYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETKVLSELGVDA-QSLSAMEI-- 180
Cdd:PTZ00427 99 KNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEYEIEKENNINKkEDILKMGIdv 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 181 -REKARSFAQAAIEKQKSAFVRWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKPVYWSPSSRTALAEAELE 259
Cdd:PTZ00427 179 yNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTPISNFELN 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 260 YNPEHV-SRSIYVRFPLLRPPPKLES----------LTDASSPV-------------------------SVLVWTTQPWT 303
Cdd:PTZ00427 259 LNYKDTpDPSIIISFVLCSDFPKVEEecnieedkqlLGEKYSVLynnkrensnngnnnstnnvcyaqhsEILAWTTTPWT 338
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 304 IPANQAICYMPEAKYAVVKCSASGHLYILAEDKIAPVASALE---TTFDVVAAFSGVDLEGgTCSHPLT---------PD 371
Cdd:PTZ00427 339 LPSNLALCVNEHFTYLRIHHVKSNRVVIVGECRLEWIMKELKwnvEDLKIVNRFKGKELKG-LRYKPLFtnfyekynfKE 417
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 372 KVSPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSL--PMDCL----VDEGGMFTDAAgPELQNkAVLKEGTDVVIK 445
Cdd:PTZ00427 418 RAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidPEKNIfidpLDANGYFTNEV-EEVQN-LYIKEADNVIKK 495
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 446 MLQATKNVLKEENIVHSYPCDWRTKTPVLIRASKQWFVNITDIKAAAKESLKTVKFIPGAAL-----NSMTDMLDrrpyW 520
Cdd:PTZ00427 496 KLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNNETTYWIPAHIKekkfhNWIKDAKD----W 571
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 521 CISRQRVWGVPIPVFHHKtKDEYLINSQTTEHIIKL--------VEQHGSD-VWWTLPAEQLLPaevlaqaggpgALEYA 591
Cdd:PTZ00427 572 CISRNRYWGTPIPIWADE-KMETVICVESIKHLEELsgvknindLHRHFIDhIEIKNPKGKTYP-----------KLKRI 639
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 592 PgqDILDIWFDSGT--------SWSCVLQDTQQ--RADLYLEGKDQLGGWFQSSLLTSVATRSKAPFRTVMVHGFTLGEK 661
Cdd:PTZ00427 640 P--EVFDCWFESGSmpyakvhyPFSTEKEDFHKifPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLASD 717
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 662 GEKMSKSLGNVINPDTIISggkdhskepPYGADILRWWI-------AESNVFTEVTIGPSVLSAarddISKLRNTLRFLL 734
Cdd:PTZ00427 718 GKKMSKRLKNYPDPLYILD---------KYGADSLRLYLinsvavrAENLKFQEKGVNEVVKSF----ILPFYHSFRFFS 784
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 735 GNLTGFNP--------ETDSVpVKNMYVIDQYMLHLIQDFATKITDSYKQYDFGKVV-RLLKafYTRELSSFYFSIVKDR 805
Cdd:PTZ00427 785 QEVTRYEClnkkqflfNTDYI-YKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLpKLLQ--FIENLTNWYIRLNRDR 861
|
810 820 830 840
....*....|....*....|....*....|....*....|....
gi 38490690 806 LYCENEKDPKRRSCQTaLAEILDVLVRAFAPILPHLAEEVFQHI 849
Cdd:PTZ00427 862 MRGSLGEENCLQSLCT-TYRTLHLFTVLMAPFTPFITEYIYQQL 904
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
123-858 |
1.15e-68 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 246.94 E-value: 1.15e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 123 HVGHALNKILKDIANRFHMMRGSKVHFVPGWDcH-GLPIETKV---LSELGVDAQSLSameiREKarsFAQAAIE-KQKS 197
Cdd:PRK05729 52 HMGHALNNTLQDILIRYKRMQGYNTLWLPGTD-HaGIATQMVVerqLAAEGKSRHDLG----REK---FLEKVWEwKEES 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 198 AFV------RWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKPVYWSPSSRTALAEAELEYNPEHvSRSIYV 271
Cdd:PRK05729 124 GGTitnqlrRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVK-GKLWHI 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 272 RFPLlrpppkleslTDASSpvSVLVWTTQPWTIPANQAICYMPE-AKYAvvkcsasghlyilaedkiapvasalettfdv 350
Cdd:PRK05729 203 RYPL----------ADGSD--YLVVATTRPETMLGDTAVAVNPEdERYK------------------------------- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 351 vaafsgvDLEGGTCSHPLTpDKVSPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEGGMFTDAAGpEL 430
Cdd:PRK05729 240 -------HLIGKTVILPLV-GREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTINENPG-EY 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 431 QnkavlkeGTDV------VIKMLQATKNVLKEENIVHSYP-CDwRTKTPVLIRASKQWFVNITDIKAAAKESLKT--VKF 501
Cdd:PRK05729 311 Q-------GLDRfearkaIVADLEELGLLVKIEPHTHSVGhSD-RSGVVIEPYLSDQWFVKMKPLAKPALEAVENgeIKF 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 502 IPGAALNS----MTDMLDrrpyWCISRQRVWGVPIPVfhhktkdeylinsqttehiiklveqhgsdvwWTLPAEQLLPAE 577
Cdd:PRK05729 383 VPERWEKTyfhwMENIQD----WCISRQLWWGHRIPA-------------------------------WYDEDGEVYVGR 427
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 578 VLAQAGGPGALEyapgQ--DILDIWFDSGTsW--SCvLQDTQQRADLylegKDqlggWFQSSLLTS--------VAtR-- 643
Cdd:PRK05729 428 EEPEAREKALLT----QdeDVLDTWFSSAL-WpfST-LGWPEKTEDL----KR----FYPTSVLVTgfdiiffwVA-Rmi 492
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 644 -------SKAPFRTVMVHGFTLGEKGEKMSKSLGNVINPDTIISggkdhskepPYGADILRWWIAESNVFTE-VTIGPSV 715
Cdd:PRK05729 493 mmglhftGQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLID---------KYGADALRFTLAALASPGRdIRFDEER 563
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 716 LSAARDDISKLRNTLRFLLGNLTGFNPETDSvPVKNMYVIDQYMLHLIQDFATKITDSYKQYDFGKVVRLLKAFYTRELS 795
Cdd:PRK05729 564 VEGYRNFANKLWNASRFVLMNLEGADVGELP-DPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIWNEFC 642
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38490690 796 SFYFSIVKDRLYcenekDPKRRSCQTALAEILDVLVRAFAPILPHLAEEVFQHIPYVTEPKSV 858
Cdd:PRK05729 643 DWYLELAKPVLQ-----EAAKRATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGIEESI 700
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
115-895 |
8.92e-68 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 246.83 E-value: 8.92e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 115 PPYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETKVLSEL----GVDAQSLSAMEIREKARSFAQ- 189
Cdd:PRK14900 56 PPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATQMIVEKELkkteKKSRHDLGREAFLERVWAWKEq 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 190 --AAIEKQKSAFvrwGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKPVYWSPSSRTALAEAELEYNPEHVSR 267
Cdd:PRK14900 136 ygSRIGEQHKAL---GASLDWQRERFTMDEGLSRAVREVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHQGE 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 268 SIYVRFPLlrpppkleslTDASSpvSVLVWTTQPWTIPANQAICYMPE-AKYavvkcsasghlyilaedkiapvasalet 346
Cdd:PRK14900 213 LWSFAYPL----------ADGSG--EIVVATTRPETMLGDTAVAVHPLdPRY---------------------------- 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 347 tfdvvaafsgVDLEGGTCSHPLTPDKVSPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEGGMFTDAA 426
Cdd:PRK14900 253 ----------MALHGKKVRHPITGRTFPIVADAILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRMTAEA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 427 GP--ELQNKAVLKEgtdvvIKMLQATKNVLKEENiVHSYP---CDwRTKTPVLIRASKQWFVNITDIKAAAKESLKT--V 499
Cdd:PRK14900 323 GPlaGLDRFEARKE-----VKRLLAEQGLDRGAK-PHVLPlgrCQ-RSATILEPLLSDQWYVRIEPLARPAIEAVEQgrT 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 500 KFIPGAALNSMTDMLDRRPYWCISRQRVWGVPIPVfhhktkdeylinsqttehiiklveqhgsdvWWTLPAEQLLPAEVL 579
Cdd:PRK14900 396 RFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPA------------------------------WYCPDGHVTVARETP 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 580 AQAGGPGALEYAPGQDILDIWFDSG------TSWScvlQDTQQRADLY----LE-GKDQLGGWFQSSLLTSVATRSKAPF 648
Cdd:PRK14900 446 EACSTCGKAELRQDEDVLDTWFSSGlwpfstMGWP---EQTDTLRTFYptsvMEtGHDIIFFWVARMMMMGLHFMGEVPF 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 649 RTVMVHGFTLGEKGEKMSKSLGNVINPDTIIsggkdhskePPYGADILRWWIAE-SNVFTEVTIGPSVLSAARDDISKLR 727
Cdd:PRK14900 523 RTVYLHPMVRDEKGQKMSKTKGNVIDPLVIT---------EQYGADALRFTLAAlTAQGRDIKLAKERIEGYRAFANKLW 593
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 728 NTLRFLLGNLTGFnpETDSVPVKN--MYVIDQYMLHLIQDFATKITDSYKQYDFGKVVRLLKAFYTRELSSFYFSIVKDR 805
Cdd:PRK14900 594 NASRFALMNLSGY--QERGEDPARlaRTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHELCDWYIELAKEA 671
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 806 LYCENEKdpKRRSCQTALAEILDVLVRAFAPILPHLAEEVFQHIpyvtePKSVFRTGWINTSSIWKKPGLEEAVESACAM 885
Cdd:PRK14900 672 LASEDPE--ARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVL-----RAQVGASAWADSVLAAEYPRKGEADEAAEAA 744
|
810
....*....|
gi 38490690 886 RDSFLGSIPG 895
Cdd:PRK14900 745 FRPVLGIIDA 754
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
123-880 |
3.59e-66 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 239.95 E-value: 3.59e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 123 HVGHALNKILKDIANRFHMMRGSKVHFVPGWDcH-GLPIETKV---LSELGVDAQSLSameiREKarsFAQAAIE-KQKS 197
Cdd:COG0525 51 HMGHALNNTLQDILIRYKRMQGYNTLWQPGTD-HaGIATQAVVerqLAEEGKSRHDLG----REK---FLERVWEwKEES 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 198 AFV------RWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKPVYWSPSSRTALAEAELEYnpEHVSRSIY- 270
Cdd:COG0525 123 GGTitnqlrRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEH--EEVKGHLWh 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 271 VRFPLlrpppklesltdASSPVSVLVWTTQPWTIPANQAICYMPE-AKYAvvkcsasghlyilaedkiapvasalettfd 349
Cdd:COG0525 201 IRYPL------------ADGSGYIVVATTRPETMLGDTAVAVHPEdERYK------------------------------ 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 350 vvaafsgvDLEGGTCSHPLTpDKVSPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPM-DCLVDEGGMfTDAAGp 428
Cdd:COG0525 239 --------HLIGKTVILPLV-GREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMiNILDEDGTI-NENAG- 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 429 ELQnkavlkeGTDV------VIKMLQATKNVLKEENIVHSYP-CDwRTKTPVLIRASKQWFVNITDIKAAAKESLKT--V 499
Cdd:COG0525 308 KYR-------GLDRfearkaIVADLEELGLLVKVEPHKHSVGhSD-RSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDgeI 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 500 KFIPGAALNS----MTDMLDrrpyWCISRQRVWGVPIPVFHHKTKDEYlinsqttehiiklVEQHgsdvwwtlpaeqllP 575
Cdd:COG0525 380 KFVPERWEKTyfhwMENIRD----WCISRQLWWGHRIPAWYCPDGEVY-------------VART--------------E 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 576 AEVLAQAGGpGALEyapgQ--DILDIWFDSGtSW--ScVL---QDTqqrADL-YlegkdqlggWFQSSLLTS-------- 639
Cdd:COG0525 429 PEACAKAGS-VNLT----QdeDVLDTWFSSA-LWpfS-TLgwpEKT---EDLkY---------FYPTSVLVTgfdiiffw 489
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 640 VAtR---------SKAPFRTVMVHGFTLGEKGEKMSKSLGNVINPDTIISggkdhskepPYGADILRWWIAESNvftevt 710
Cdd:COG0525 490 VA-RmimmglhftGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLID---------KYGADALRFTLAALA------ 553
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 711 igpsvlSAARD---DIS----------KLRNTLRFLLGNLTGFNPETDSVPVKNMyVIDQYMLHLIQDFATKITDSYKQY 777
Cdd:COG0525 554 ------SPGRDikfDEErvegyrnfanKLWNASRFVLMNLEGFDPGLDPDPEELS-LADRWILSRLNKTIAEVTEALEKY 626
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 778 DFGKVVRLLKAFYTRELSSFYFSIVKDRLYCENEKDpkRRSCQTALAEILDVLVRAFAPILPHLAEEVFQHIPYVTEPKS 857
Cdd:COG0525 627 RFDEAAQALYDFVWNEFCDWYLELAKPRLYGGDEAA--KRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPPRKEGES 704
|
810 820
....*....|....*....|...
gi 38490690 858 VFRTGWINTSSIWKKPGLEEAVE 880
Cdd:COG0525 705 IMLAPWPEADEELIDEEAEAEFE 727
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
115-880 |
2.04e-62 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 230.28 E-value: 2.04e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 115 PPYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLP----IETKVLSELGVDAQSLSAMEIREKARSFAQ- 189
Cdd:PTZ00419 68 PPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIAtqvvVEKKLMKEENKTRHDLGREEFLKKVWEWKDk 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 190 --AAIEKQksaFVRWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKPVYWSPSSRTALAEAELEYnpEHVSR 267
Cdd:PTZ00419 148 hgNNICNQ---LRRLGSSLDWSREVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEF--EEIEK 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 268 SIYVRFPLLRPPPKLESLTDASSPV------SVLVWTTQPWTIPANQAICYMPE-AKYAvvkcsasghlyilaedkiapv 340
Cdd:PTZ00419 223 PTKITIPGYDKKVEVGVLWHFAYPLedsgqeEIVVATTRIETMLGDVAVAVHPKdERYK--------------------- 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 341 asalettfdvvaafsgvDLEGGTCSHPLTPDKVSPL-LPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEG 419
Cdd:PTZ00419 282 -----------------KLHGKELIHPFIPDRKIPIiADDELVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLD 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 420 GMFTDAAGP-------ELQNKavlkegtdvVIKMLQaTKNVLKEEnIVHSY--PCDWRTK---TPVLIrasKQWFVNITD 487
Cdd:PTZ00419 345 GKINENGGEfagmhrfDCRRK---------IEEELK-EMGLLRDK-VPNPMrlPRCSRSGdivEPMLI---PQWYVNCKD 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 488 IkaaAKESLKTV-----KFIPGAALNSMTDMLDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINSQTtehiiklveqhgs 562
Cdd:PTZ00419 411 M---AKRAVEAVrngelKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVISKGPETDPSDE------------- 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 563 DVWWTLPAEQLLPAEVLAQAGGPGA-LEYAPGQDILDIWFDSG------TSWSCVLQDTQQ--RADLYLEGKDQLGGWFQ 633
Cdd:PTZ00419 475 EPWVVARSEEEALEKAKKKFGLSEEdFELEQDEDVLDTWFSSGlfpfstLGWPDQTDDLQRffPTSLLETGSDILFFWVA 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 634 SSLLTSVATRSKAPFRTVMVHGFTLGEKGEKMSKSLGNVINPDTIISG------------GKDHSKE------------- 688
Cdd:PTZ00419 555 RMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGislqdlnqklyeGNLPEKEikraielqkkefp 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 689 ---PPYGADILRWWIAesnvftevtigpSVLSAARD---DIS----------KLRNTLRFLLGNLTGFNPETDSVPVKNM 752
Cdd:PTZ00419 635 ngiPECGTDALRFGLL------------AYTQQGRNinlDINrvvgyrhfcnKLWNAVKFALMKLLKDFNLPNSTLFKPN 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 753 YV-----IDQYMLHLIQDFATKITDSYKQYDFGKVVRLLKAFYTRELSSFYFSIVKDRLyCENEKDPKRRSCQTALAEIL 827
Cdd:PTZ00419 703 NVeslpwEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIKPRL-SKQSDGERKQHAQDVLHTVL 781
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....
gi 38490690 828 DVLVRAFAPILPHLAEEVFQHIP-YVTEPKSVFRTGWINTSSIWKKPGLEEAVE 880
Cdd:PTZ00419 782 DIGLRLLHPMMPFITEELYQRLPnYLRKSESISIAKYPQPNPGWNNEALDEEMK 835
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
115-867 |
1.41e-57 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 215.19 E-value: 1.41e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 115 PPYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIE---TKVLSELGVDAQSLSAMEIREKARSFAQAA 191
Cdd:PLN02943 96 PPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQlvvEKMLASEGIKRTDLGRDEFTKRVWEWKEKY 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 192 IEKQKSAFVRWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKPVYWSPSSRTALAEAELEYNpEHVSRSIYV 271
Cdd:PLN02943 176 GGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDLEVEYS-EEPGTLYYI 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 272 RFPLlrpppklesltdASSPVSVL-VWTTQPWTIPANQAICYMPE-AKYAVvkcsasghlYIlaeDKIAPVasalettfd 349
Cdd:PLN02943 255 KYRV------------AGGSEDFLtIATTRPETLFGDVAIAVNPEdDRYSK---------YI---GKMAIV--------- 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 350 vvaafsgvdleggtcshPLTPDKVSPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEGGMFTDAAGpe 429
Cdd:PLN02943 302 -----------------PMTYGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLNEVAG-- 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 430 lqnkAVLKEGTDVVIKMLQATKNVLKEENIVHSYPCDWRTKTPVLIRASKQWFVNITDIKAAAKESL--KTVKFIPGAAL 507
Cdd:PLN02943 363 ----LYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVenGELTIIPERFE 438
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 508 NSMTDMLDRRPYWCISRQRVWGVPIPVFHHKTKD---EYLINSQTTEHIIKLVEQHGSDVwwtlpaeqllpaevlaqagg 584
Cdd:PLN02943 439 KIYNHWLSNIKDWCISRQLWWGHRIPVWYIVGKDceeDYIVARSAEEALEKAREKYGKDV-------------------- 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 585 pgalEYAPGQDILDIWFDSGT------SWSCVLQDTQQR---ADLYLEGKDQLGGWFQSSLLTSVATRSKAPFRTVMVHG 655
Cdd:PLN02943 499 ----EIYQDPDVLDTWFSSALwpfstlGWPDVSAEDFKKfypTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHG 574
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 656 FTLGEKGEKMSKSLGNVINP-DTIisggkdhsKEppYGADILRWWIAESNVFTEVTIGPSVLSAARDDISKLRNTLRFLL 734
Cdd:PLN02943 575 LIRDSQGRKMSKTLGNVIDPlDTI--------KE--FGTDALRFTLALGTAGQDLNLSTERLTSNKAFTNKLWNAGKFVL 644
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 735 GNLTG--------------FNPETD--SVPVKNMYVIDQymLHLIQDfatKITDSYKQYDFGKVVRLLKAFYTRELSSFY 798
Cdd:PLN02943 645 QNLPSqsdtsawehilackFDKEESllSLPLPECWVVSK--LHELID---SVTTSYDKYFFGDVGREIYDFFWSDFADWY 719
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38490690 799 FSIVKDRLYcENEKDPKRRSCQTALAEILDVLVRAFAPILPHLAEEVFQHIPYvtEPKSVFRTGWINTS 867
Cdd:PLN02943 720 IEASKTRLY-HSGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQALPY--RKEALIVSPWPQTS 785
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
115-701 |
1.19e-48 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 177.82 E-value: 1.19e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 115 PPYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETKVLSELGVDAQSLSAM---EIREKARSFAQAA 191
Cdd:cd00817 9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTRHDLgreEFLEKCWEWKEES 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 192 IEKQKSAFVRWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKPVYWSPSSRTALAEAELeynpehVSRSIYV 271
Cdd:cd00817 89 GGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV------CSRSGDV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 272 RFPLLrpppklesltdasspvsvlvwTTQPWtipanqaicympeakyavVKCSasghlyilaedkiapvasalettfdvv 351
Cdd:cd00817 163 IEPLL---------------------KPQWF------------------VKVK--------------------------- 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 352 aafsgvdleggtcshpltpdkvspllpathvTMAkgtglvhtapahgmedysvasqhslpmdclvdeggmftdaagpelq 431
Cdd:cd00817 177 -------------------------------DLA---------------------------------------------- 179
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 432 nKAVLKEGTDVVIKMlqatknvlkeenivhsYPCDWRtktpvliRASKQWFVNITDikaaakeslktvkfipgaalnsmt 511
Cdd:cd00817 180 -KKALEAVKEGDIKF----------------VPERME-------KRYENWLENIRD------------------------ 211
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 512 dmldrrpyWCISRQRVWGVPIPVFHHKTKDEylinsqttehiiklveqhgsdvWWTLPAEQL--LPAEVLAQAGGPGAlE 589
Cdd:cd00817 212 --------WCISRQLWWGHRIPAWYCKDGGH----------------------WVVAREEDEaiDKAAPEACVPCGGE-E 260
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 590 YAPGQDILDIWFDSG------TSWscvLQDTQ-----QRADLYLEGKDQLGGWFQSSLLTSVATRSKAPFRTVMVHGFTL 658
Cdd:cd00817 261 LKQDEDVLDTWFSSSlwpfstLGW---PEETKdlkkfYPTSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVR 337
|
570 580 590 600
....*....|....*....|....*....|....*....|...
gi 38490690 659 GEKGEKMSKSLGNVINPDTIISGgkdhskeppYGADILRWWIA 701
Cdd:cd00817 338 DEDGRKMSKSLGNVIDPLDVIDG---------YGADALRFTLA 371
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
109-297 |
1.34e-44 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 163.74 E-value: 1.34e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 109 FCLHDGPPYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETKVLSELGVDAQSLSAMEIREKARSFA 188
Cdd:cd00668 2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIWIEEFREDPKEFV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 189 QAAIEKQKSAFVRWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKPVYWSPS---SRTALAEAELEYN---- 261
Cdd:cd00668 82 EEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPVRITEQwffDMPKFKEKLLKALrrgk 161
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 38490690 262 --PEHV----------------SRSIYVRFPLlrPPPKLESLTDAS-SPVSVLVW 297
Cdd:cd00668 162 ivPEHVknrmeawleslldwaiSRQRYWGTPL--PEDVFDVWFDSGiGPLGSLGY 214
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
115-900 |
8.37e-43 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 169.69 E-value: 8.37e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 115 PPYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLP----IETKVLSELGVDAQSLSAME-IRE--KARSF 187
Cdd:PLN02381 136 PPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIAtqvvVEKKLMRERHLTRHDIGREEfVSEvwKWKDE 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 188 AQAAIEKQksaFVRWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKPVYWSPSSRTALAEAELEYNpeHVSR 267
Cdd:PLN02381 216 YGGTILNQ---LRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYI--DIKE 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 268 SIYVRFPLLRPPPKLESLTDASSPVS-----VLVWTTQPWTIPANQAICYMPE-AKYAvvkcsasgHLYilaedkiapva 341
Cdd:PLN02381 291 RTLLKVPGYDKPVEFGVLTSFAYPLEgglgeIVVATTRIETMLGDTAIAIHPDdERYK--------HLH----------- 351
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 342 salettfdvvaafsgvdleGGTCSHPLTPDKVSPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEGGM 421
Cdd:PLN02381 352 -------------------GKFAVHPFNGRKLPIICDAILVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGK 412
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 422 FTDAAGPELQNKAVLkEGTDVVIKMLQATKNVLKEENIVHSYPCDWRTKTPVLIRASKQWFVNITD-----IKAAAKESL 496
Cdd:PLN02381 413 INSNGGSEFAGMPRF-AAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCSSmakqaLDAAIDGEN 491
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 497 KTVKFIPGAALNSMTDMLDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINSQTTehiiklveqhgSDVWWTLPAEQLLPA 576
Cdd:PLN02381 492 KKLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYVTLEDDQLKELGSY-----------NDHWVVARNESDALL 560
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 577 EvlAQAGGPGA-LEYAPGQDILDIWFDSGTSWSCVL---QDTQQRADLY----LE-GKDQLGGWFQSSLLTSVATRSKAP 647
Cdd:PLN02381 561 E--ASQKFPGKkFELSQDPDVLDTWFSSGLFPLSVLgwpDDTDDLKAFYptsvLEtGHDILFFWVARMVMMGMQLGGDVP 638
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 648 FRTVMVHGFTLGEKGEKMSKSLGNVINPDTIISG----------------------GKDHSKE------PPYGADILRW- 698
Cdd:PLN02381 639 FRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGisleglhkrleegnldpkelvvAKEGQKKdfpngiAECGTDALRFa 718
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 699 ---WIAESNvftEVTIGPSVLSAARDDISKLRNTLRFLLGNL-TGFNPETdSVPVKNMYVIDQYMLHLIQDFATKITDSY 774
Cdd:PLN02381 719 lvsYTAQSD---KINLDILRVVGYRQWCNKLWNAVRFAMSKLgDDYTPPA-TLSVETMPFSCKWILSVLNKAISKTVSSL 794
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 775 KQYDFGKVVRLLKAFYTRELSSFYFSIVKDRLYCEN-EKDPKRRSCQTALAEILDVLVRAFAPILPHLAEEVFQHIPYV- 852
Cdd:PLN02381 795 DAYEFSDAASTVYSWWQYQFCDVFIEAIKPYFAGDNpEFASERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLPQPk 874
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|...
gi 38490690 853 --TEPKSVFRTGWINTSSIWKKPGLE---EAVESACAMRDSFLGSIPGKNAAE 900
Cdd:PLN02381 875 dhTRKDSIMISEYPSAVEAWTNEKVEyemDLVLSTVKCLRSLRAEVLEKQKNE 927
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
470-701 |
4.81e-36 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 139.09 E-value: 4.81e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 470 KTPVLIRASKQWFVNITDIKAAAKESLKTVKFIPGAALNSMTDMLDRRPYWCISRQRVWGVPIPvfhhktkdeylinsqt 549
Cdd:cd00668 131 RGTHPVRITEQWFFDMPKFKEKLLKALRRGKIVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP---------------- 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 550 tEHIIklveqhgsDVWWTLPAEQLlpaevlaqaggpGALEYAPGQDILDIWFDsgtswscvlqdtqqrADLYLEGKDQLG 629
Cdd:cd00668 195 -EDVF--------DVWFDSGIGPL------------GSLGYPEEKEWFKDSYP---------------ADWHLIGKDILR 238
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38490690 630 GWFQSSLLTSVATRSKAPFRTVMVHGFTLGEKGEKMSKSLGNVINPDTIISggkdhskepPYGADILRWWIA 701
Cdd:cd00668 239 GWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVE---------KYGADALRYYLT 301
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
122-845 |
7.39e-31 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 131.14 E-value: 7.39e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 122 PHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETkvLSEL---GvDAQSLSA--------MEIREK------- 183
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPILG--IAERiarG-DPETIELykslygipEEELEKfkdpeyi 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 184 ARSFAQAAiekqKSAFVRWGVMADWNNCYYTFDPKYEA---KQlrvFYQMYEKGLVYRSYKPVYWSPSSRTALAEAELey 260
Cdd:PRK12300 78 VEYFSEEA----KEDMKRIGYSIDWRREFTTTDPEYSKfieWQ---FRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDL-- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 261 nPEHVSRSIyVRFPLLrpppKLESLTDASSPVSvlvwTTQPWTIPANQAICYMPEAKYAVVKcsASGHLYILAEDkiapV 340
Cdd:PRK12300 149 -LDGEEPEI-VEYTLI----KFEESEDLILPAA----TLRPETIFGVTNLWVNPDATYVKAE--VDGEKWIVSKE----A 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 341 ASAL---ETTFDVVAAFSGVDLEGGTCSHPLTPDKVsPLLPATHVTMAKGTGLVHTAPAHGMEDYsVA-----SQHSLPM 412
Cdd:PRK12300 213 AEKLsfqDRDVEIIEEIKGSELIGKKVKNPVTGKEV-PILPADFVDPDNGTGVVMSVPAHAPYDY-VAlrdlkKNKELLD 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 413 D------CLVDEGGMF-----------TDAAGPELQ-----------NKAVLKEGTDV-----VIKMLQATKNVLKEENI 459
Cdd:PRK12300 291 ViepiplIEVEGYGEFpakevveklgiKSQEDPELEeatkevyraefHKGVLKENTGEyagkpVREAREKITKDLIEKGI 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 460 ------VHSYPCDWRTKTPVLIRASK-QWFVNITD--IKAAAKESLKTVKFIPG---AALNSMTDMLDRRPywCiSRQRV 527
Cdd:PRK12300 371 adimyeFSNRPVYCRCGTECVVKVVKdQWFIDYSDpeWKELAHKALDNMEIIPEeyrKEFENTIDWLKDRA--C-ARRRG 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 528 WGVPIPVfhhktKDEYLINSQT---------TehIIKLVEQHGsdvwwtLPAEQLLPA---EVLAQAGGPGALEYAPG-- 593
Cdd:PRK12300 448 LGTRLPW-----DEEWIIESLSdstiymayyT--IAHKIREYG------IKPEQLTPEffdYVFLGKGDPEEVSKKTGip 514
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 594 QDILDiwfdsgtswscvlqdtQQRA--------DLYLEGKDQLGGW--FQssLLTSVAT--RSKAPfRTVMVHGFTLGEk 661
Cdd:PRK12300 515 KEILE----------------EMREeflywypvDWRHSGKDLIPNHltFF--IFNHVAIfpEEKWP-RGIVVNGFVLLE- 574
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 662 GEKMSKSLGNVINPDTIIsggkdhsKEppYGADILRWWIAES-NVFTEVTIGPSVLSAARDDISKLRNTLRFLLGnLTGF 740
Cdd:PRK12300 575 GKKMSKSKGNVIPLRKAI-------EE--YGADVVRLYLTSSaELLQDADWREKEVESVRRQLERFYELAKELIE-IGGE 644
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 741 NPETDsvpvknmyvIDQYMLHLIQDFATKITDSYKQYDFGKVVRLLkafytrelssfYFSIVKD-RLYCENEKDPKRRsc 819
Cdd:PRK12300 645 EELRF---------IDKWLLSRLNRIIKETTEAMESFQTRDAVQEA-----------FYELLNDlRWYLRRVGEANNK-- 702
|
810 820
....*....|....*....|....*.
gi 38490690 820 qtALAEILDVLVRAFAPILPHLAEEV 845
Cdd:PRK12300 703 --VLREVLEIWIRLLAPFTPHLAEEL 726
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
116-863 |
8.51e-27 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 117.84 E-value: 8.51e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 116 PYANGDPHVGHALNKILKDIANRFHMMRGSKV-HfvP-GWDCHGLP-----IETKVlselgvdaqslsameireKARSFA 188
Cdd:COG0495 42 PYPSGRLHMGHVRNYTIGDVVARYKRMQGYNVlH--PmGWDAFGLPaenaaIKNGV------------------HPAEWT 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 189 QAAIEKQKSAFVRWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKPVYWSPSSRTALA-E------------ 255
Cdd:COG0495 102 YENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWCPVDQTVLAnEqvidgrcwrcga 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 256 -----------------AE--------LEYNPEHV----------SRSIYVRFPLLRPPPKLEsltdasspvsvlVWTTQ 300
Cdd:COG0495 182 pvekkelpqwflkitdyADellddldkLDGWPEKVktmqrnwigrSEGAEVDFPVEGSDEKIT------------VFTTR 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 301 PWTIPAnqaicympeAKYAVVkcsASGHlyILAEdKIAPVASALEttfdvVAAF-------------------SGVDLeG 361
Cdd:COG0495 250 PDTLFG---------ATFMVL---APEH--PLVK-ELATPEQNAA-----VAAFieeakkkseiertsetkekTGVFT-G 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 362 GTCSHPLTPDKVsPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEGgmftDAAGPELQNKAVLKEGTd 441
Cdd:COG0495 309 LYAINPLTGEKI-PIWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPE----DGDDPDILEEAYTGDGV- 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 442 vvikmlqatknvlkeenIVHSYPCDWrtktpvliraskqwfVNITDIKAAAKESL-------KTVKFipgaalnSMTDml 514
Cdd:COG0495 383 -----------------LINSGEFDG---------------LDSEEAKEAIIEWLeekglgkRKVNY-------RLRD-- 421
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 515 drrpyWCISRQRVWGVPIPVFHhktkDEylinsqttehiiklveqHGSDVwwTLPAEQL---LPAEV---------LAQA 582
Cdd:COG0495 422 -----WLISRQRYWGEPIPIIH----CE-----------------DCGVV--PVPEDQLpveLPEDVdfdptggspLARA 473
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 583 -----------GGPGALEYapgqDILDIWFDSgtSW-----SCVLQDTQ----QRA------DLYLEG------------ 624
Cdd:COG0495 474 pewvnvtcpkcGGPARRET----DTMDTFVDS--SWyylryTDPHNDEApfdpEAAnywlpvDQYIGGiehailhllyar 547
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 625 ------KDqLGgwfqssLLTsvatrSKAPFRTVMVHG--FTLGEKG------EKMSKSLGNVINPDTIISggkdhskepP 690
Cdd:COG0495 548 fftkvlRD-LG------LVS-----FDEPFKRLLTQGmvLEVGKDGvviggiEKMSKSKGNVVDPDEIIE---------K 606
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 691 YGADILRWWIaesnvftevtigpsvLSAARDDISKLRNT------LRFL---------LGNLTGFNPETDSVPVKNMYvi 755
Cdd:COG0495 607 YGADTLRLFE---------------MFAGPPERDLEWSDsgvegaYRFLnrvwrlvvdEAEALKLDVADLSEADKELR-- 669
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 756 dqYMLH-LIQdfatKITDSYKQYDFGKVV-RLLKafYTRELSSFYFSIVKDRlycenekdpkrrscqTALAEILDVLVRA 833
Cdd:COG0495 670 --RALHkTIK----KVTEDIERLRFNTAIaALME--LVNALYKAKDSGEADR---------------AVLREALETLVLL 726
|
890 900 910
....*....|....*....|....*....|
gi 38490690 834 FAPILPHLAEEVFQHIPYvtePKSVFRTGW 863
Cdd:COG0495 727 LAPFAPHIAEELWERLGH---EGSVADAPW 753
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
756-863 |
3.87e-25 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 102.10 E-value: 3.87e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 756 DQYMLHLIQDFATKITDSYKQYDFGKVVRLLKAFYTRELSSFYFSIVKDRLYCENEKDpkrrSCQTALAEILDVLVRAFA 835
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDS----RAQTTLYEVLETLLRLLA 76
|
90 100
....*....|....*....|....*...
gi 38490690 836 PILPHLAEEVFQHipyvtepKSVFRTGW 863
Cdd:pfam08264 77 PFMPFITEELWQK-------ESIHLAPW 97
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
720-887 |
6.07e-22 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 94.16 E-value: 6.07e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 720 RDDISKLRNTLRFLLG--NLTGFNPETDSVPVKNMYVIDQYMLHLIQDFATKITDSYKQYDFGKVVRLLKAFyTRELSSF 797
Cdd:cd07961 11 RKVLLPLWNAYRFFVTyaNLDGFDPGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEF-IDELTNW 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 798 YFSIVKDRLYCENEKDPKRRSCQTaLAEILDVLVRAFAPILPHLAEEVFQHI--PYVTEPKSVFRTGWINTSSIWKKPGL 875
Cdd:cd07961 90 YIRRNRKRFWGEEGDDDKLAAYAT-LYEVLLTLSRLMAPFTPFITEEIYQNLrrELGDAPESVHLLDWPEVDESLIDEEL 168
|
170
....*....|..
gi 38490690 876 EEAVEsacAMRD 887
Cdd:cd07961 169 EEAME---LVRE 177
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
116-245 |
2.06e-21 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 96.16 E-value: 2.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 116 PYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETkvlselgvdaqslSAMEIREKARSFAQAAIEKQ 195
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAEN-------------AAIKIGRDPEDWTEYNIKKM 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 38490690 196 KSAFVRWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKPVYW 245
Cdd:cd00812 76 KEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNW 125
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
725-849 |
3.52e-21 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 90.31 E-value: 3.52e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 725 KLRNTLRFLLGNLTGFNPetDSVPVKNMYVIDQYMLHLIQDFATKITDSYKQYDFGKVVRLLKAFYTRELSSFYFSIVKD 804
Cdd:cd07962 15 KLWNAARFVLMNLEDDDE--PEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFWNDFCDWYLELVKP 92
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 38490690 805 RLYceNEKDPKRRSCQTALAEILDVLVRAFAPILPHLAEEVFQHI 849
Cdd:cd07962 93 RLY--GEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
28-844 |
4.00e-20 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 96.43 E-value: 4.00e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 28 PSRLGCLGMTRRLVVRSVAGADSPQSSSKGGRYRDTVLLPQTSFPMKLLGrQQSDMELEIQQKCGFSELYS-WQR---ER 103
Cdd:PLN02563 18 FTSLRLSLFLVVSSAQTPASASSYFRRSRRGGVSRSLTRRAFAAPSALTS-TTAKTTPAAKRAYPFHEIEPkWQRyweEN 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 104 KV----------KTEFCLHDGPPYANGDP-HVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETkvlselgvda 172
Cdd:PLN02563 97 RTfrtpddvdtsKPKFYVLDMFPYPSGAGlHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLPAEQ---------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 173 qslSAMEIREKARSFAQAAIEKQKSAFVRWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKPVYWSPSSRTA 252
Cdd:PLN02563 167 ---YAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 253 LAEaeleynpEHVSRSIYVR--FPLLRPPPK-------------LESLTDASSPVSV----------------------- 294
Cdd:PLN02563 244 LAN-------EEVVDGLSERggHPVIRKPMRqwmlkitayadrlLEDLDDLDWPESIkemqrnwigrsegaeldfsvldg 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 295 ---------LVWTTQPWTIPANQAICYMPEAKYAVVKCSASGHLYILAEDKIAPVASALETTfDVVAAFSGVDlEGGTCS 365
Cdd:PLN02563 317 egkerdekiTVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEQKEAVEEYVDAASRKSDLERT-ELQKEKTGVF-TGSYAI 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 366 HPLTPDKVsPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEG-GMFTDAagpelqNKAVLKEGTdvvi 444
Cdd:PLN02563 395 NPATGEAI-PIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPAdGNEDDA------EKAYTGEGV---- 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 445 kmlqatknvlkeenIVHSypcdwrtktpvlirASKQWFVNITDIKAAAKeslKTVKFIPGAALNSMTDMLDRRPyWCISR 524
Cdd:PLN02563 464 --------------IVNS--------------SSSGLDINGLSSKEAAK---KVIEWLEETGNGKKKVNYKLRD-WLFAR 511
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 525 QRVWGVPIPVFHHKTKDEylinsqttehIIKLVEqhgSDVWWTLPAEQLL-----PAEVLAQA-----------GGPGAL 588
Cdd:PLN02563 512 QRYWGEPIPVVFLEDSGE----------PVPVPE---SDLPLTLPELDDFtptgtGEPPLAKAvswvntvdpssGKPARR 578
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 589 EyapgQDILDIWfdSGTSW----------SCVLQDTQQR-----ADLYLEGKDQ-----LGGWFQSSLLTSV-ATRSKAP 647
Cdd:PLN02563 579 E----TNTMPQW--AGSCWyylrfmdpknSNALVDKEKEkywmpVDLYVGGAEHavlhlLYARFWHKVLYDIgVVSTKEP 652
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 648 FRTVMVHGFTLGE-------------------------------------KGE-----------------KMSKSLGNVI 673
Cdd:PLN02563 653 FQCLVNQGMILGEveytafkdsdgeyvsadtadrlgelqqekipeekvikSGDsfvlkddpsirliarahKMSKSRGNVV 732
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 674 NPDTIISggkdhskepPYGADILRWWiaesnvftEVTIGPsvlsaARDdiSKLRNT------LRFL--LGNLTGFNPETD 745
Cdd:PLN02563 733 NPDDVVS---------EYGADSLRLY--------EMFMGP-----LRD--SKTWSTsgvegvHRFLgrTWRLVVGAPLPD 788
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 746 SVPVKNMYVIDQYM----LHLIQDFATKITDSYKQYDFGKVVRLLKAFyTRELSSFyfsivkdrlycenEKDPKrrscqt 821
Cdd:PLN02563 789 GSFRDGTVVTDEEPsleqLRLLHKCIAKVTEEIESTRFNTAISAMMEF-TNAAYKW-------------DKVPR------ 848
|
970 980
....*....|....*....|...
gi 38490690 822 alaEILDVLVRAFAPILPHLAEE 844
Cdd:PLN02563 849 ---EAIEPFVLLLSPYAPHLAEE 868
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
116-255 |
9.06e-16 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 79.50 E-value: 9.06e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 116 PYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETKVLsELGVDAQslsamEIREKARsfaqaaiEKQ 195
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAE-EEGVTPQ-----ELCDKYH-------EIF 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 38490690 196 KSAFVRWGVMADwnncYY--TFDPK-YEAKQlRVFYQMYEKGLVY-RSYKPVYwSPSSRTALAE 255
Cdd:cd00814 76 KDLFKWLNISFD----YFirTTSPRhKEIVQ-EFFKKLYENGYIYeGEYEGLY-CVSCERFLPE 133
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
116-259 |
4.57e-15 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 79.34 E-value: 4.57e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 116 PYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETKVLSElGVDAQSLsameirekarsfaqaaIEKQ 195
Cdd:TIGR00398 8 PYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAEQE-GLTPKEL----------------VDKY 70
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 196 KSAFVRwgvMADWNNCYY-----TFDPKYEAKQLRVFYQMYEKGLVY-RSYKPVYwSPSSRTALAEAELE 259
Cdd:TIGR00398 71 HEEFKD---DWKWLNISFdrfirTTDEEHKEIVQKIFQKLKENGYIYeKEIKQLY-CPECEMFLPDRYVE 136
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
116-259 |
2.07e-14 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 76.17 E-value: 2.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 116 PYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETKVLsELGVDAQSLSAMEIREKARSFAQAAIEkq 195
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAE-KEGITPEELVDRYHEIHREDFKKFNIS-- 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38490690 196 KSAFVRwgvmadwnncyyTFDPK-YEAKQLrVFYQMYEKGLVYRSYKPVYWSPSSRTALAEAELE 259
Cdd:pfam09334 85 FDDYGR------------TTSERhHELVQE-FFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVE 136
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
462-701 |
1.89e-13 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 72.28 E-value: 1.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 462 SYPCDWRtktpvliRASKQWFVNI--TDIKAAAKESLKTVKFIPGAALNSMTDMLDrrpywcISRQRVWGVPIPVfhhkt 539
Cdd:cd00812 120 EAPVNWC-------KLLDQWFLKYseTEWKEKLLKDLEKLDGWPEEVRAMQENWIG------CSRQRYWGTPIPW----- 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 540 kdEYLINSQttehiiklveqhgSDVWW-----TLPAEQLLPAEVLAQAGGPGALEYAPgqdildiwfdsgtswscvlqdt 614
Cdd:cd00812 182 --TDTMESL-------------SDSTWyyaryTDAHNLEQPYEGDLEFDREEFEYWYP---------------------- 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 615 qqrADLYLEGKDQLGGWFQSSLLTSVATRSKA-----PFRTVMVHGFTLGEkGEKMSKSLGNVINPDTIIsggkdhsKEp 689
Cdd:cd00812 225 ---VDIYIGGKEHAPNHLLYSRFNHKALFDEGlvtdePPKGLIVQGMVLLE-GEKMSKSKGNVVTPDEAI-------KK- 292
|
250
....*....|..
gi 38490690 690 pYGADILRWWIA 701
Cdd:cd00812 293 -YGADAARLYIL 303
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
649-847 |
3.39e-13 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 73.22 E-value: 3.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 649 RTVMVHGF-TLgeKGEKMSKSLGNVINPDTIIsggkDHskeppYGADILRWWIAESNVFTEvtigPSVLSaaRDDI---- 723
Cdd:COG0143 313 KKVFAHGFlTV--EGEKMSKSRGNVIDPDDLL----DR-----YGPDALRYYLLREVPFGQ----DGDFS--WEDFvarv 375
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 724 -SKLRNTlrflLGNL----TGF-NPETDSV--PVKNMYVIDQYMLHLIQDFATKITDSYKQYDFGKVVRLLkafytRELS 795
Cdd:COG0143 376 nSDLAND----LGNLasrtLSMiHKYFDGKvpEPGELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEI-----MALA 446
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38490690 796 SF---YFSivkdrlycENE-----KDPKRRSCQTAL---AEILDVLVRAFAPILPHLAEEVFQ 847
Cdd:COG0143 447 RAankYID--------ETApwklaKDEDPERLATVLytlLEALRILAILLKPFLPETAEKILE 501
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
116-255 |
5.28e-13 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 72.84 E-value: 5.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 116 PYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETKVLSElGVDAQSLsAMEIRekarsfaqaaiEKQ 195
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKE-GITPQEL-VDRIH-----------AEF 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38490690 196 KSAFVRWGVmaDWNNCYYTFDPK-YEAKQlRVFYQMYEKGLVY-RSYKpVYWSPSSRTALAE 255
Cdd:COG0143 77 KELFEKLGI--SFDNFIRTTSPEhKELVQ-EIFQRLYDNGDIYkGEYE-GWYCPECERFLPD 134
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
719-838 |
7.45e-13 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 65.99 E-value: 7.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 719 ARDDISKLRNTLRFLLGNLTGFNPETDSVPVKNMyviDQYMLHLIQDFATKITDSYKQYDFGKVVRLLKAFyTRELsSFY 798
Cdd:cd07375 7 ARAFLNRLYRLLSFFRKALGGTQPKWDNELLEEA---DRELLARLQEFIKRTTNALEALDPTTAVQELFKF-TNEL-NWY 81
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 38490690 799 FSIVKDRLYCENEkdpkRRSCQTALAEILDVLVRAFAPIL 838
Cdd:cd07375 82 LDELKPALQTEEL----REAVLAVLRAALVVLTKLLAPFT 117
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
115-241 |
9.15e-11 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 65.67 E-value: 9.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 115 PPYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETKVLsELGVDAQSLSameiREKARSFAQ--AAI 192
Cdd:PRK11893 9 IYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAE-EAGISPQELA----DRNSAAFKRlwEAL 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 38490690 193 EKQKSAFVRwgvmadwnncyyTFDPKYEAKQLRVFYQMYEKGLVY-RSYK 241
Cdd:PRK11893 84 NISYDDFIR------------TTDPRHKEAVQEIFQRLLANGDIYlGKYE 121
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
116-193 |
1.29e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 65.56 E-value: 1.29e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 38490690 116 PYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETKVLSElGVDAQSLSAMEIREKARSFAQAAIE 193
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKE-GITPEELIARYHAEHKRDFAGFGIS 87
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
648-847 |
9.71e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 62.21 E-value: 9.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 648 FRTVMVHGF-TLgeKGEKMSKSLGNVINPDTIIsggkDHskeppYGADILRWWIAesnvfTEVTIG-PSVLSaaRDDISK 725
Cdd:PRK11893 284 PKRVFAHGFlTL--DGEKMSKSLGNVIDPFDLV----DE-----YGVDAVRYFLL-----REIPFGqDGDFS--REAFIN 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 726 LRN-TLRFLLGNL------------TGFNPETDSVPVKnmyviDQYMLHLIQDFATKITDSYKQYDFGKVvrllkAFYTR 792
Cdd:PRK11893 346 RINaDLANDLGNLaqrtlsmiaknfDGKVPEPGALTEA-----DEALLEAAAALLERVRAAMDNLAFDKA-----LEAIL 415
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38490690 793 ELSSF---YFSIVKD-RLYcenEKDPKRrscqtaLAEILDVL---VRAFA----PILPHLAEEVFQ 847
Cdd:PRK11893 416 ALVRAankYIDEQAPwSLA---KTDPER------LATVLYTLlevLRGIAvllqPVMPELAAKILD 472
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
475-701 |
4.57e-09 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 59.08 E-value: 4.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 475 IRASKQWFVNITDIKAAAKESLKT--VKFIPGAALNSMTDMLDR--RPyWCISRQRV-WGVPIPVFhhktkdeylinsqt 549
Cdd:cd00814 134 WREEEHYFFRLSKFQDRLLEWLEKnpDFIWPENARNEVLSWLKEglKD-LSITRDLFdWGIPVPLD-------------- 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 550 TEHIIKlveqhgsdVWWTLPAEQLlpaevlaqaggpGALEYAPGQDILDIWFDSGtswscvlqdtqQRADLYLEGKDQLg 629
Cdd:cd00814 199 PGKVIY--------VWFDALIGYI------------SATGYYNEEWGNSWWWKDG-----------WPELVHFIGKDII- 246
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38490690 630 gWFQS-----SLLtsvATRSKAPfRTVMVHGFTLGEkGEKMSKSLGNVINPDTIIsggkDHskeppYGADILRWWIA 701
Cdd:cd00814 247 -RFHAiywpaMLL---GAGLPLP-TRIVAHGYLTVE-GKKMSKSRGNVVDPDDLL----ER-----YGADALRYYLL 308
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
117-163 |
5.96e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 56.73 E-value: 5.96e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 38490690 117 YANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETK 163
Cdd:PRK12267 14 YPNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHGQKIQQA 60
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
82-863 |
7.03e-08 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 56.62 E-value: 7.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 82 DMELEIQ---QKcgfselySWQRERKVKTEFCLH-DGP----------PYANGDPHVGHA--LNKIlkDIANRFHMMRGS 145
Cdd:PLN02959 13 DRLLEIEvavQK-------WWEEEKVFEAEAGDEpPKPgekffgnfpyPYMNGLLHLGHAfsLSKL--EFAAAYHRLRGA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 146 KVHFVPGWDCHGLPIET---KVLSELG-----------VDAQSLSAMEIREKARSFAQA----------AIEKQKSAFVR 201
Cdd:PLN02959 84 NVLLPFAFHCTGMPIKAsadKLAREIQqygnppvfpeeDEDEAAAVAAAKAEAEAAAAPpdkfkgkkskAVAKSGTQKYQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 202 WGVM-------------------------------------ADWNNCYYTFD--PKYEA---KQLRVFYQM--YEKGLVY 237
Cdd:PLN02959 164 WEIMrsfglpdseiakfqdpyhwlsyfpplakedlkafglgCDWRRSFITTDvnPYYDAfvrWQFRKLKKKgkIVKDKRY 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 238 RSYKPVYWSPSSRTALAEAELEYNPEHVSRSIYVRFPLlrpPPKLESLtdASSPVSVLVWTTQPWTIpANQAICY-MPEA 316
Cdd:PLN02959 244 TIYSPLDGQPCADHDRASGEGVGPQEYVLIKMEVLPPF---PGKLKAL--EGKKVFLAAATLRPETM-YGQTNCWvLPDG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 317 KYAVVKCSAsGHLYILAE-----------DKIAPVASALETtfdvvaaFSGVDLEGGTCSHPLTPDKVSPLLPATHVTMA 385
Cdd:PLN02959 318 KYGAYEIND-TEVFILTAraalnlayqnfSKVPGKPTCLVE-------LTGYDLIGLPLKSPLAFNEVIYALPMLTILTD 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 386 KGTGLVHTAPAHGMED----------------YSVASQHSLPMD---CLVDEGgmFTDAAGPEL--------QN-KAVLK 437
Cdd:PLN02959 390 KGTGVVTSVPSDSPDDymalsdlkakpalrakYGVKDEWVLPFEvvpIINIPE--FGDKSAEKVcedlkiksQNdKEKLA 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 438 EG---------TDVVI-------KMLQATKNVLKEE------NIVHSYPcdwrtKTPVLIRASKQWFVNITD-------- 487
Cdd:PLN02959 468 EAkrltylkgfTDGTMlvgeyagRKVQEAKPLIKKKlieagqAILYSEP-----EKKVMSRSGDECVVALTDqwyltyge 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 488 --IKAAAKESLKTVKFIPGAALNSMTDMLDRRPYWCISRQRVWGVPIPVfhhktkDE-YLINS----------QTTEHI- 553
Cdd:PLN02959 543 eeWKKKAEKCLSKMNLYSDETRHGFEHTLGWLNQWACSRSFGLGTRIPW------DEqFLIESlsdstiymayYTVAHLl 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 554 ------------IKlVEQHGSDVW------WTLPAEQLLPAEVLAQAggpgALEYapgqdilDIWFDsgtswscvlqdtq 615
Cdd:PLN02959 617 qggdmygkdkssIK-PEQMTDEVWdfvfcgGPLPKSSDIPAELLEKM----KQEF-------EYWYP------------- 671
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 616 qrADLYLEGKDQLGGWFQSSLLTSVATRSKAP----FRT---VMVHgftlgekGEKMSKSLGNVInpdTIisggKDHSKE 688
Cdd:PLN02959 672 --FDLRVSGKDLIQNHLTFAIYNHTAIWAEEHwprgFRCnghLMLN-------SEKMSKSTGNFL---TL----RQAIEE 735
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 689 ppYGADILRWWIAESN--------VF-----------TEVTIGPSVLSAArddiSKLRntlrfllgnlTGfnPETDsvpv 749
Cdd:PLN02959 736 --FSADATRFALADAGdgvddanfVFetanaailrltKEIAWMEEVLAAE----SSLR----------TG--PPST---- 793
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 750 knmyVIDQYMLHLIqDFATKIT-DSYKQYDFGKVvrLLKAFYtrELssfyfsivkdrlycENEKDPKRRSCQTA------ 822
Cdd:PLN02959 794 ----YADRVFENEI-NIAIAETeKNYEAMMFREA--LKSGFY--DL--------------QAARDEYRLSCGSGgmnrdl 850
|
970 980 990 1000
....*....|....*....|....*....|....*....|.
gi 38490690 823 LAEILDVLVRAFAPILPHLAEEVFQHIpyVTEPKSVFRTGW 863
Cdd:PLN02959 851 VWRFMDVQTRLITPICPHYAEHVWREI--LKKEGFAVTAGW 889
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
651-845 |
4.76e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 54.00 E-value: 4.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 651 VMVHGF-TLgeKGEKMSKSLGNVINPDTIIsggkDHskeppYGADILRWWIAesnvftevtigpSVLSAARDDI------ 723
Cdd:PRK00133 317 VFAHGFlTV--EGAKMSKSRGTFIWARTYL----DH-----LDPDYLRYYLA------------AKLPETIDDLdfnwed 373
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 724 ------SKLRNTLrfllGNLT----GF-NPETDSVPVKNmyVIDQYMLHLIQDFATKITDSYKQYDFGKVVRLlkafyTR 792
Cdd:PRK00133 374 fqqrvnSELVGKV----VNFAsrtaGFiNKRFDGKLPDA--LADPELLEEFEAAAEKIAEAYEAREFRKALRE-----IM 442
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 38490690 793 ELSSF---YFSivkdrlycENE-----KDPKRRsCQTALA---EILDVLVRAFAPILPHLAEEV 845
Cdd:PRK00133 443 ALADFankYVD--------DNEpwklaKQDGER-LQAVCSvglNLFRALAIYLKPVLPELAERA 497
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
647-697 |
5.45e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 50.18 E-value: 5.45e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 38490690 647 PFRTVMVHGFTLGeKGEKMSKSLGNVINPDTIIsggkDHskeppYGADILR 697
Cdd:PRK12267 283 LPKKVFAHGWWLM-KDGKMSKSKGNVVDPEELV----DR-----YGLDALR 323
|
|
| zf-FPG_IleRS |
pfam06827 |
Zinc finger found in FPG and IleRS; This zinc binding domain is found at the C-terminus of ... |
985-1006 |
2.29e-04 |
|
Zinc finger found in FPG and IleRS; This zinc binding domain is found at the C-terminus of isoleucyl tRNA synthetase and the enzyme Formamidopyrimidine-DNA glycosylase EC:3.2.2.23.
Pssm-ID: 429140 [Multi-domain] Cd Length: 28 Bit Score: 39.11 E-value: 2.29e-04
10 20
....*....|....*....|....*..
gi 38490690 985 EKCPRCWKHTSETADA-----LCPRCA 1006
Cdd:pfam06827 2 EKCPRCWTYIEKVGVGgrstyFCPRCQ 28
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
755-845 |
4.35e-04 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 41.04 E-value: 4.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 755 IDQYMLHLIQDFATKITDSYKQYDFgkvvrllkafytRE-LSSFYFSIVKDRlyceneKDPKRRS----CQTALAEILDV 829
Cdd:cd07959 36 IDRWLLSRLNRLIKETTEAYENMQF------------REaLKEGLYELQNDL------DWYRERGgagmNKDLLRRFIEV 97
|
90
....*....|....*.
gi 38490690 830 LVRAFAPILPHLAEEV 845
Cdd:cd07959 98 WTRLLAPFAPHLAEEI 113
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
117-244 |
4.75e-04 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 43.93 E-value: 4.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 117 YANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETKVLSElGVDAQSLSAMeIREKARSFAQaAIEKQK 196
Cdd:PLN02224 79 YVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGEKIATSAAAN-GRNPPEHCDI-ISQSYRTLWK-DLDIAY 155
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 38490690 197 SAFVRwgvmadwnncyyTFDPKYEAKQLRVFYQMYEKGLVYRS-YKPVY 244
Cdd:PLN02224 156 DKFIR------------TTDPKHEAIVKEFYARVFANGDIYRAdYEGLY 192
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
356-412 |
6.81e-04 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 41.76 E-value: 6.81e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 38490690 356 GVDlEGGTCSHPLTPDKVsPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPM 412
Cdd:pfam13603 82 GVF-TGLYAIHPITGEKI-PIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPI 136
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
662-830 |
1.03e-03 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 42.78 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 662 GEKMSKSLGNVINPDTIISggkdhskepPYGADILRWWIAESN-----VFTEvtigpSVLSAARDDISKLRNTLRFLLGN 736
Cdd:COG0215 263 GEKMSKSLGNFFTVRDLLK---------KYDPEVLRFFLLSAHyrsplDFSE-----EALEEAEKALERLYNALRRLEEA 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490690 737 LTGFNPETDSVPVknmyvidqymlhLIQDFATKITDsykqyDFGkvvrllkafyTRELSSFYFSIVKD--RLYCENEKDP 814
Cdd:COG0215 329 LGAADSSAEEIEE------------LREEFIAAMDD-----DFN----------TPEALAVLFELVREinKALDEGEDKA 381
|
170
....*....|....*.
gi 38490690 815 KRRSCQTALAEILDVL 830
Cdd:COG0215 382 ALAALAALLRALGGVL 397
|
|
| tRNA-synt_1f |
pfam01921 |
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from ... |
660-728 |
4.93e-03 |
|
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from prokaryotes.
Pssm-ID: 396483 Cd Length: 357 Bit Score: 40.32 E-value: 4.93e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38490690 660 EKGEKMSKSLGNVINPDTIISGGkdhskePPygaDILRWWIAESNVFTEVTIGPSVLSAARDDISKLRN 728
Cdd:pfam01921 275 KGGGKMSSSKGNVITPEDWLEYA------PP---ESLRFLMFRTKPKKAKDLDFDVIPRLVDEYDRLER 334
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
647-704 |
5.76e-03 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 39.48 E-value: 5.76e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 38490690 647 PFRTVMVHGFTLGEKGEKMSKSLGNVInpdTIisggKDHSKEppYGADILRWWIAESN 704
Cdd:cd00672 157 PFARYWLHTGHLTIDGEKMSKSLGNFI---TV----RDALKK--YDPEVLRLALLSSH 205
|
|
| |
