|
Name |
Accession |
Description |
Interval |
E-value |
| LRRC37AB_C |
pfam14914 |
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ... |
1468-1590 |
2.96e-65 |
|
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation. :
Pssm-ID: 464370 Cd Length: 147 Bit Score: 217.67 E-value: 2.96e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 1468 SPGDQFEIQLTQQLQSVIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLVSRTGHLMKLLSGQQEVKASKIEWDTDQWK 1547
Cdd:pfam14914 1 SPGDQFEIQLNQQLLSLIPNVDVRRLISHVIRTLKMDCSEPQMQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 75677612 1548 TENYINESTEAQSEQKE-KSLEFTKELPGYGYTKKLILALIVTG 1590
Cdd:pfam14914 81 NENYINESTEAQSKQKKqSSRELTKEVPGYGYNNKLILAISVTV 124
|
|
| LRRC37 |
pfam15779 |
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ... |
560-629 |
5.86e-22 |
|
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen. :
Pssm-ID: 434930 [Multi-domain] Cd Length: 73 Bit Score: 90.89 E-value: 5.86e-22
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75677612 560 EVELSPTMKETPTQP---PKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHST 629
Cdd:pfam15779 1 EVEPSPTQQETPTQPpesPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
892-949 |
5.61e-15 |
|
Leucine rich repeat; :
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 70.63 E-value: 5.61e-15
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 75677612 892 EKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVI 949
Cdd:pfam13855 4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRRC37 |
pfam15779 |
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ... |
251-319 |
1.42e-14 |
|
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen. :
Pssm-ID: 434930 [Multi-domain] Cd Length: 73 Bit Score: 70.08 E-value: 1.42e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75677612 251 EEEPSSMQQEAPALPPESSMESL--TLPNHEVSVQPPGEDQAYY-HLPNITVKPADVEVTITSEPTNETESS 319
Cdd:pfam15779 1 EVEPSPTQQETPTQPPESPKEVVaqPPVHHEVTVPTPGQGQAQHpTLPNVTVQPLDLELTITPEPTKEAEHS 72
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
868-1018 |
8.89e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription]; :
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 75.36 E-value: 8.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 868 TILNFQGNYISYIDGNVwkaYSWT--EKLILRENNLTELHkDSFEGLLSLQYLDLSCNKIQSIERHtFEPLPFLKFINLS 945
Cdd:COG4886 116 ESLDLSGNQLTDLPEEL---ANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLS 190
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75677612 946 CNVITELSfgtfQAWHGMQFLHKLILNHNPLTTVEDPyLFKLPALKYLDMGTTlvPLTTLKNILMMTvELEKL 1018
Cdd:COG4886 191 NNQITDLP----EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--QLTDLPELGNLT-NLEEL 255
|
|
| LRRC37 |
pfam15779 |
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ... |
332-429 |
2.00e-12 |
|
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen. :
Pssm-ID: 434930 [Multi-domain] Cd Length: 73 Bit Score: 63.92 E-value: 2.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 332 EVEPSATQQEAPIEPPVPPmehelsiseqqqpvqpsessrevessptqQETPGQPPEHHEVTVSPPGHHQTHHLASPSVS 411
Cdd:pfam15779 1 EVEPSPTQQETPTQPPESP-----------------------------KEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVT 51
|
90
....*....|....*...
gi 75677612 412 VKPPDVQLTIAAEPSAEV 429
Cdd:pfam15779 52 VQPLDLELTITPEPTKEA 69
|
|
| PRK10263 super family |
cl35903 |
DNA translocase FtsK; Provisional |
206-704 |
2.10e-12 |
|
DNA translocase FtsK; Provisional The actual alignment was detected with superfamily member PRK10263:
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 72.43 E-value: 2.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 206 PPGPSEQVGPSQFHLE----PETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPssMQQEAPALPPESSMESLTLPNHEVS 281
Cdd:PRK10263 344 PPVASVDVPPAQPTVAwqpvPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEP--LQQPVQPQQPYYAPAAEQPAQQPYY 421
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 282 VQPPGEDQAYYHLPNITVKPA--------DVEVTITSEPTNETESSQAQ---QETPIQFPEEVEPSATQQEAP----IEP 346
Cdd:PRK10263 422 APAPEQPAQQPYYAPAPEQPVagnawqaeEQQSTFAPQSTYQTEQTYQQpaaQEPLYQQPQPVEQQPVVEPEPvveeTKP 501
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 347 PVPPMEHELSISEQQ-----------QPV-QPSESSREVESSPTQQETPGQPPEHHEVTVSP--PGHHQTHHLASPSVSV 412
Cdd:PRK10263 502 ARPPLYYFEEVEEKRarereqlaawyQPIpEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPlaSGVKKATLATGAAATV 581
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 413 KPPDVQLTIAAEPSAEVGTSLVHQ-------EATTRLSGSGNDVEPPAIQhggppLLPESSEEAGPLAVQQETSFQSPEP 485
Cdd:PRK10263 582 AAPVFSLANSGGPRPQVKEGIGPQlprpkriRVPTRRELASYGIKLPSQR-----AAEEKAREAQRNQYDSGDQYNDDEI 656
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 486 INNENPSPTQQEAAAEHPQTAEEGESSLTHQ----EAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLG-FTITP----- 555
Cdd:PRK10263 657 DAMQQDELARQFAQTQQQRYGEQYQHDVPVNaedaDAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDdFEFSPmkall 736
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 556 -ESMTEVELSPT-MKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEpTTEVGHSTPPKR 633
Cdd:PRK10263 737 dDGPHEPLFTPIvEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ-YQQPQQPVAPQP 815
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75677612 634 TIVSPKHPEVTLPHPDQVQTQhshltrATVQPLDLgfTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSD 704
Cdd:PRK10263 816 QYQQPQQPVAPQPQYQQPQQP------VAPQPQDT--LLHPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSE 878
|
|
| LRRC37 |
pfam15779 |
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ... |
689-739 |
1.16e-11 |
|
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen. :
Pssm-ID: 434930 [Multi-domain] Cd Length: 73 Bit Score: 61.61 E-value: 1.16e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 75677612 689 TAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSP 739
Cdd:pfam15779 23 VAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| LRRC37AB_C |
pfam14914 |
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ... |
1468-1590 |
2.96e-65 |
|
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.
Pssm-ID: 464370 Cd Length: 147 Bit Score: 217.67 E-value: 2.96e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 1468 SPGDQFEIQLTQQLQSVIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLVSRTGHLMKLLSGQQEVKASKIEWDTDQWK 1547
Cdd:pfam14914 1 SPGDQFEIQLNQQLLSLIPNVDVRRLISHVIRTLKMDCSEPQMQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 75677612 1548 TENYINESTEAQSEQKE-KSLEFTKELPGYGYTKKLILALIVTG 1590
Cdd:pfam14914 81 NENYINESTEAQSKQKKqSSRELTKEVPGYGYNNKLILAISVTV 124
|
|
| LRRC37 |
pfam15779 |
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ... |
560-629 |
5.86e-22 |
|
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.
Pssm-ID: 434930 [Multi-domain] Cd Length: 73 Bit Score: 90.89 E-value: 5.86e-22
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75677612 560 EVELSPTMKETPTQP---PKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHST 629
Cdd:pfam15779 1 EVEPSPTQQETPTQPpesPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
892-949 |
5.61e-15 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 70.63 E-value: 5.61e-15
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 75677612 892 EKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVI 949
Cdd:pfam13855 4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRRC37 |
pfam15779 |
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ... |
251-319 |
1.42e-14 |
|
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.
Pssm-ID: 434930 [Multi-domain] Cd Length: 73 Bit Score: 70.08 E-value: 1.42e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75677612 251 EEEPSSMQQEAPALPPESSMESL--TLPNHEVSVQPPGEDQAYY-HLPNITVKPADVEVTITSEPTNETESS 319
Cdd:pfam15779 1 EVEPSPTQQETPTQPPESPKEVVaqPPVHHEVTVPTPGQGQAQHpTLPNVTVQPLDLELTITPEPTKEAEHS 72
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
868-1018 |
8.89e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 75.36 E-value: 8.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 868 TILNFQGNYISYIDGNVwkaYSWT--EKLILRENNLTELHkDSFEGLLSLQYLDLSCNKIQSIERHtFEPLPFLKFINLS 945
Cdd:COG4886 116 ESLDLSGNQLTDLPEEL---ANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLS 190
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75677612 946 CNVITELSfgtfQAWHGMQFLHKLILNHNPLTTVEDPyLFKLPALKYLDMGTTlvPLTTLKNILMMTvELEKL 1018
Cdd:COG4886 191 NNQITDLP----EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--QLTDLPELGNLT-NLEEL 255
|
|
| LRRC37 |
pfam15779 |
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ... |
332-429 |
2.00e-12 |
|
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.
Pssm-ID: 434930 [Multi-domain] Cd Length: 73 Bit Score: 63.92 E-value: 2.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 332 EVEPSATQQEAPIEPPVPPmehelsiseqqqpvqpsessrevessptqQETPGQPPEHHEVTVSPPGHHQTHHLASPSVS 411
Cdd:pfam15779 1 EVEPSPTQQETPTQPPESP-----------------------------KEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVT 51
|
90
....*....|....*...
gi 75677612 412 VKPPDVQLTIAAEPSAEV 429
Cdd:pfam15779 52 VQPLDLELTITPEPTKEA 69
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
206-704 |
2.10e-12 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 72.43 E-value: 2.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 206 PPGPSEQVGPSQFHLE----PETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPssMQQEAPALPPESSMESLTLPNHEVS 281
Cdd:PRK10263 344 PPVASVDVPPAQPTVAwqpvPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEP--LQQPVQPQQPYYAPAAEQPAQQPYY 421
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 282 VQPPGEDQAYYHLPNITVKPA--------DVEVTITSEPTNETESSQAQ---QETPIQFPEEVEPSATQQEAP----IEP 346
Cdd:PRK10263 422 APAPEQPAQQPYYAPAPEQPVagnawqaeEQQSTFAPQSTYQTEQTYQQpaaQEPLYQQPQPVEQQPVVEPEPvveeTKP 501
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 347 PVPPMEHELSISEQQ-----------QPV-QPSESSREVESSPTQQETPGQPPEHHEVTVSP--PGHHQTHHLASPSVSV 412
Cdd:PRK10263 502 ARPPLYYFEEVEEKRarereqlaawyQPIpEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPlaSGVKKATLATGAAATV 581
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 413 KPPDVQLTIAAEPSAEVGTSLVHQ-------EATTRLSGSGNDVEPPAIQhggppLLPESSEEAGPLAVQQETSFQSPEP 485
Cdd:PRK10263 582 AAPVFSLANSGGPRPQVKEGIGPQlprpkriRVPTRRELASYGIKLPSQR-----AAEEKAREAQRNQYDSGDQYNDDEI 656
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 486 INNENPSPTQQEAAAEHPQTAEEGESSLTHQ----EAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLG-FTITP----- 555
Cdd:PRK10263 657 DAMQQDELARQFAQTQQQRYGEQYQHDVPVNaedaDAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDdFEFSPmkall 736
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 556 -ESMTEVELSPT-MKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEpTTEVGHSTPPKR 633
Cdd:PRK10263 737 dDGPHEPLFTPIvEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ-YQQPQQPVAPQP 815
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75677612 634 TIVSPKHPEVTLPHPDQVQTQhshltrATVQPLDLgfTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSD 704
Cdd:PRK10263 816 QYQQPQQPVAPQPQYQQPQQP------VAPQPQDT--LLHPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSE 878
|
|
| LRRC37 |
pfam15779 |
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ... |
689-739 |
1.16e-11 |
|
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.
Pssm-ID: 434930 [Multi-domain] Cd Length: 73 Bit Score: 61.61 E-value: 1.16e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 75677612 689 TAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSP 739
Cdd:pfam15779 23 VAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
|
|
| LRRC37 |
pfam15779 |
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ... |
508-565 |
8.03e-10 |
|
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.
Pssm-ID: 434930 [Multi-domain] Cd Length: 73 Bit Score: 56.60 E-value: 8.03e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75677612 508 EGESSLTHQEAPAQTPEFPNVVVAQPP---------------EHSHLTQATVQPLDLGFTITPESMTEVELSP 565
Cdd:pfam15779 1 EVEPSPTQQETPTQPPESPKEVVAQPPvhhevtvptpgqgqaQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
874-978 |
9.78e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 48.63 E-value: 9.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 874 GNYISYIDGnvwkayswTEKLilreNNLTELH---------------KDSFEGLL-SLQYLDLSCNKIQSIErhTFEPLP 937
Cdd:cd21340 77 GNRISVVEG--------LENL----TNLEELHienqrlppgekltfdPRSLAALSnSLRVLNISGNNIDSLE--PLAPLR 142
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 75677612 938 FLKFINLSCNVITELS--FGTFQAWHgmqFLHKLILNHNPLTT 978
Cdd:cd21340 143 NLEQLDASNNQISDLEelLDLLSSWP---SLRELDLTGNPVCK 182
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| LRRC37AB_C |
pfam14914 |
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ... |
1468-1590 |
2.96e-65 |
|
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.
Pssm-ID: 464370 Cd Length: 147 Bit Score: 217.67 E-value: 2.96e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 1468 SPGDQFEIQLTQQLQSVIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLVSRTGHLMKLLSGQQEVKASKIEWDTDQWK 1547
Cdd:pfam14914 1 SPGDQFEIQLNQQLLSLIPNVDVRRLISHVIRTLKMDCSEPQMQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 75677612 1548 TENYINESTEAQSEQKE-KSLEFTKELPGYGYTKKLILALIVTG 1590
Cdd:pfam14914 81 NENYINESTEAQSKQKKqSSRELTKEVPGYGYNNKLILAISVTV 124
|
|
| LRRC37 |
pfam15779 |
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ... |
560-629 |
5.86e-22 |
|
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.
Pssm-ID: 434930 [Multi-domain] Cd Length: 73 Bit Score: 90.89 E-value: 5.86e-22
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75677612 560 EVELSPTMKETPTQP---PKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHST 629
Cdd:pfam15779 1 EVEPSPTQQETPTQPpesPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
892-949 |
5.61e-15 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 70.63 E-value: 5.61e-15
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 75677612 892 EKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVI 949
Cdd:pfam13855 4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRRC37 |
pfam15779 |
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ... |
251-319 |
1.42e-14 |
|
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.
Pssm-ID: 434930 [Multi-domain] Cd Length: 73 Bit Score: 70.08 E-value: 1.42e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75677612 251 EEEPSSMQQEAPALPPESSMESL--TLPNHEVSVQPPGEDQAYY-HLPNITVKPADVEVTITSEPTNETESS 319
Cdd:pfam15779 1 EVEPSPTQQETPTQPPESPKEVVaqPPVHHEVTVPTPGQGQAQHpTLPNVTVQPLDLELTITPEPTKEAEHS 72
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
868-1018 |
8.89e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 75.36 E-value: 8.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 868 TILNFQGNYISYIDGNVwkaYSWT--EKLILRENNLTELHkDSFEGLLSLQYLDLSCNKIQSIERHtFEPLPFLKFINLS 945
Cdd:COG4886 116 ESLDLSGNQLTDLPEEL---ANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLS 190
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75677612 946 CNVITELSfgtfQAWHGMQFLHKLILNHNPLTTVEDPyLFKLPALKYLDMGTTlvPLTTLKNILMMTvELEKL 1018
Cdd:COG4886 191 NNQITDLP----EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--QLTDLPELGNLT-NLEEL 255
|
|
| LRRC37 |
pfam15779 |
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ... |
332-429 |
2.00e-12 |
|
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.
Pssm-ID: 434930 [Multi-domain] Cd Length: 73 Bit Score: 63.92 E-value: 2.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 332 EVEPSATQQEAPIEPPVPPmehelsiseqqqpvqpsessrevessptqQETPGQPPEHHEVTVSPPGHHQTHHLASPSVS 411
Cdd:pfam15779 1 EVEPSPTQQETPTQPPESP-----------------------------KEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVT 51
|
90
....*....|....*...
gi 75677612 412 VKPPDVQLTIAAEPSAEV 429
Cdd:pfam15779 52 VQPLDLELTITPEPTKEA 69
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
206-704 |
2.10e-12 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 72.43 E-value: 2.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 206 PPGPSEQVGPSQFHLE----PETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPssMQQEAPALPPESSMESLTLPNHEVS 281
Cdd:PRK10263 344 PPVASVDVPPAQPTVAwqpvPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEP--LQQPVQPQQPYYAPAAEQPAQQPYY 421
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 282 VQPPGEDQAYYHLPNITVKPA--------DVEVTITSEPTNETESSQAQ---QETPIQFPEEVEPSATQQEAP----IEP 346
Cdd:PRK10263 422 APAPEQPAQQPYYAPAPEQPVagnawqaeEQQSTFAPQSTYQTEQTYQQpaaQEPLYQQPQPVEQQPVVEPEPvveeTKP 501
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 347 PVPPMEHELSISEQQ-----------QPV-QPSESSREVESSPTQQETPGQPPEHHEVTVSP--PGHHQTHHLASPSVSV 412
Cdd:PRK10263 502 ARPPLYYFEEVEEKRarereqlaawyQPIpEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPlaSGVKKATLATGAAATV 581
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 413 KPPDVQLTIAAEPSAEVGTSLVHQ-------EATTRLSGSGNDVEPPAIQhggppLLPESSEEAGPLAVQQETSFQSPEP 485
Cdd:PRK10263 582 AAPVFSLANSGGPRPQVKEGIGPQlprpkriRVPTRRELASYGIKLPSQR-----AAEEKAREAQRNQYDSGDQYNDDEI 656
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 486 INNENPSPTQQEAAAEHPQTAEEGESSLTHQ----EAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLG-FTITP----- 555
Cdd:PRK10263 657 DAMQQDELARQFAQTQQQRYGEQYQHDVPVNaedaDAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDdFEFSPmkall 736
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 556 -ESMTEVELSPT-MKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEpTTEVGHSTPPKR 633
Cdd:PRK10263 737 dDGPHEPLFTPIvEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ-YQQPQQPVAPQP 815
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75677612 634 TIVSPKHPEVTLPHPDQVQTQhshltrATVQPLDLgfTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSD 704
Cdd:PRK10263 816 QYQQPQQPVAPQPQYQQPQQP------VAPQPQDT--LLHPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSE 878
|
|
| LRRC37 |
pfam15779 |
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ... |
689-739 |
1.16e-11 |
|
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.
Pssm-ID: 434930 [Multi-domain] Cd Length: 73 Bit Score: 61.61 E-value: 1.16e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 75677612 689 TAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSP 739
Cdd:pfam15779 23 VAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
868-1009 |
1.80e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 68.04 E-value: 1.80e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 868 TILNFQGNYISYIDGNVWKAYSwTEKLILRENNLTELHkDSFEGLLSLQYLDLSCNKIQSIERhTFEPLPFLKFINLSCN 947
Cdd:COG4886 162 KSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNN 238
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75677612 948 VITELSfgtfqAWHGMQFLHKLILNHNPLTTVedPYLFKLPALKYLDMGTTLVPLTTLKNIL 1009
Cdd:COG4886 239 QLTDLP-----ELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELE 293
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
914-976 |
8.78e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 58.69 E-value: 8.78e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75677612 914 SLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVITELSFGTFqawHGMQFLHKLILNHNPL 976
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAF---SGLPSLRYLDLSGNRL 61
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
190-752 |
2.02e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 66.12 E-value: 2.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 190 PYPGSLPPELRVKS-------DEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPqlleeePSSMQQEAP 262
Cdd:PHA03247 2554 PLPPAAPPAAPDRSvppprpaPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLP------PDTHAPDPP 2627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 263 alPPESSMESLTLPNHEVSVQPPGEDQAYYHLPNITVKPAdvEVTITSEPTNEteSSQAQQETPIQFPEEVEPSATQQEA 342
Cdd:PHA03247 2628 --PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPR--RARRLGRAAQA--SSPPQRPRRRAARPTVGSLTSLADP 2701
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 343 PIEPPVPPMEHELSISEQQQPVQPSESSREVESSPTQQETPGQP-----PEHHEVTVSPPGHHQTHHLASPSVSVKPPDV 417
Cdd:PHA03247 2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPagpatPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 418 QLTIAAEPSAevgtslvhQEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGPLAVQQetsfqSPEPINNENPSPTQQE 497
Cdd:PHA03247 2782 RLTRPAVASL--------SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT-----SAQPTAPPPPPGPPPP 2848
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 498 AAAEHPQTAEEGESSlthQEAPAQTPefPNVVVAQP-PEHSHLTQATVQPLDLGFTITPESMTEvelsPTMKETPTQPPK 576
Cdd:PHA03247 2849 SLPLGGSVAPGGDVR---RRPPSRSP--AAKPAAPArPPVRRLARPAVSRSTESFALPPDQPER----PPQPQAPPPPQP 2919
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 577 KVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHSTPPKRTIVSPKHPEVTLPHPDQVQTQHS 656
Cdd:PHA03247 2920 QPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGH 2999
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 657 HLTRATVQPLDLGFTITPksmtevepstalmttAPPPGHPEVTL-PPSDKGQAQHSHLTQATVQPLDLEltiTTKPTTEV 735
Cdd:PHA03247 3000 SLSRVSSWASSLALHEET---------------DPPPVSLKQTLwPPDDTEDSDADSLFDSDSERSDLE---ALDPLPPE 3061
|
570
....*....|....*..
gi 75677612 736 KPSPTTEETSTQLPDLG 752
Cdd:PHA03247 3062 PHDPFAHEPDPATPEAG 3078
|
|
| LRRC37 |
pfam15779 |
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ... |
508-565 |
8.03e-10 |
|
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.
Pssm-ID: 434930 [Multi-domain] Cd Length: 73 Bit Score: 56.60 E-value: 8.03e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75677612 508 EGESSLTHQEAPAQTPEFPNVVVAQPP---------------EHSHLTQATVQPLDLGFTITPESMTEVELSP 565
Cdd:pfam15779 1 EVEPSPTQQETPTQPPESPKEVVAQPPvhhevtvptpgqgqaQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
900-1018 |
3.40e-08 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 57.64 E-value: 3.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 900 NLTEL---HKDSFEGLLSLQYLDLSCNKIQSIERHtFEPLPFLKFINLSCNVITEL--SFGTFQAwhgmqfLHKLILNHN 974
Cdd:COG4886 97 NLTELdlsGNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLpePLGNLTN------LKSLDLSNN 169
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 75677612 975 PLTTVEDPyLFKLPALKYLDMGTTlvPLTTLKNILMMTVELEKL 1018
Cdd:COG4886 170 QLTDLPEE-LGNLTNLKELDLSNN--QITDLPEPLGNLTNLEEL 210
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
307-739 |
2.74e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 55.54 E-value: 2.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 307 TITSEPTNETESSQAQQEtpiQFPEEVEPSATQQEAPIEPPVPPMEHELSISEQ----QQPVQPSESSREVESSPTQQET 382
Cdd:pfam03154 147 SIPSPQDNESDSDSSAQQ---QILQTQPPVLQAQSGAASPPSPPPPGTTQAATAgptpSAPSVPPQGSPATSQPPNQTQS 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 383 PGQPpeHHEVTVSPPGHHQthHLASPsvsvKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVE--PPAIQHGGPP 460
Cdd:pfam03154 224 TAAP--HTLIQQTPTLHPQ--RLPSP----HPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQtgPSHMQHPVPP 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 461 ----LLPESSEEAGPLAVQQETSFQSPEPINNENPSPTQQEAAAEHPQTAEEGESSLTHQEAPAQTPeFPNVVVAQPPEH 536
Cdd:pfam03154 296 qpfpLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTP-IPQLPNPQSHKH 374
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 537 -SHLTQATVQPLDLGFTITPESMTEVELSPTMKETPTQPPKKVVPQlrvyqgvtnptpGQDQAQHPVSPSVTVQLLDLGL 615
Cdd:pfam03154 375 pPHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQ------------SQQLPPPPAQPPVLTQSQSLPP 442
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 616 TITPEPTTEVGHSTPPKRTIvsPKHPEVTLPHPdqvqtqhshltraTVQPLDLGFTITPKSMTEVEP--STALMTTAPPP 693
Cdd:pfam03154 443 PAASHPPTSGLHQVPSQSPF--PQHPFVPGGPP-------------PITPPSGPPTSTSSAMPGIQPpsSASVSSSGPVP 507
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 75677612 694 GHPEVTLPPsdkgqaqhshlTQATVQPLDLELTITTKPTTEVKPSP 739
Cdd:pfam03154 508 AAVSCPLPP-----------VQIKEEALDEAEEPESPPPPPRSPSP 542
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
823-1020 |
1.04e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 53.01 E-value: 1.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 823 KASTSTNICELCTCGDEMLSCIDLNPEQRLRQVPVPEPNTHNGTFTILNFQGNYISYIDGNVWKAYSWTEKLILRENNLT 902
Cdd:COG4886 8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 903 ELhkDSFEGLLSLQYLDLSCNKiqsierhTFEPLPFLKFINLSCNVITELSFGTFQawhgMQFLHKLILNHNPLTTVEDP 982
Cdd:COG4886 88 GL--TDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAN----LTNLKELDLSNNQLTDLPEP 154
|
170 180 190
....*....|....*....|....*....|....*...
gi 75677612 983 yLFKLPALKYLDMGTTlvPLTTLKNILMMTVELEKLIV 1020
Cdd:COG4886 155 -LGNLTNLKSLDLSNN--QLTDLPEELGNLTNLKELDL 189
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
315-809 |
1.30e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 53.79 E-value: 1.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 315 ETESSQAQQETPIqFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPVQPsessreveSSPTQQETPGQPPEhhevtv 394
Cdd:PHA03247 2542 ELASDDAGDPPPP-LPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAP--------PQSARPRAPVDDRG------ 2606
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 395 SPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVEPP--------AIQHGGPPLLPesS 466
Cdd:PHA03247 2607 DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPrrarrlgrAAQASSPPQRP--R 2684
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 467 EEAGPLAVQQETSFQSPEPINNE-NPSPTQQEAAAEHP---QTAEEGESSLTHQEAPAQTPEFPNV-----VVAQPPEHS 537
Cdd:PHA03247 2685 RRAARPTVGSLTSLADPPPPPPTpEPAPHALVSATPLPpgpAAARQASPALPAAPAPPAVPAGPATpggpaRPARPPTTA 2764
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 538 -----------------HLTQATVQPL-----DLGFTITPESMTEVELSPTMKETPTQPPKKVVPqlrvyqgvtnPTPGQ 595
Cdd:PHA03247 2765 gppapappaapaagpprRLTRPAVASLsesreSLPSPWDPADPPAAVLAPAAALPPAASPAGPLP----------PPTSA 2834
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 596 DQAQHPVSPSVTVQLLDLGLTITP-EPTTEVGHSTPPKRTIVSPKHPEVT-LPHPD-QVQTQHSHLTRATVQPLDLGFTI 672
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGGSVAPgGDVRRRPPSRSPAAKPAAPARPPVRrLARPAvSRSTESFALPPDQPERPPQPQAP 2914
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 673 TPKSMTEVEPSTALMTTAP-PPGHPEVTLPPSDKGQA-----------QHSHLTQATVqPLDLELTITTKPTTEVKPSPT 740
Cdd:PHA03247 2915 PPPQPQPQPPPPPQPQPPPpPPPRPQPPLAPTTDPAGagepsgavpqpWLGALVPGRV-AVPRFRVPQPAPSREAPASST 2993
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75677612 741 TEETSTQLPDLglaiipeptTETGHSTALEKTTAPRPDRV-QTLHrsltevtgPPTELEPA-QDSLVQSES 809
Cdd:PHA03247 2994 PPLTGHSLSRV---------SSWASSLALHEETDPPPVSLkQTLW--------PPDDTEDSdADSLFDSDS 3047
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
868-1010 |
3.82e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 51.09 E-value: 3.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 868 TILNFQGNYISYIDGNVwKAYSWTEKLILRENNLTELhkDSFEGLLSLQYLDLSCNKIQSIErhTFEPLPFLKFINLSCN 947
Cdd:COG4886 208 EELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNN 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75677612 948 VITELSFGTFQAWHGMQFLHKLILNHNPLTTVEDPYLFKLPALKYLDMGTTLVPLTTLKNILM 1010
Cdd:COG4886 283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
874-978 |
9.78e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 48.63 E-value: 9.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 874 GNYISYIDGnvwkayswTEKLilreNNLTELH---------------KDSFEGLL-SLQYLDLSCNKIQSIErhTFEPLP 937
Cdd:cd21340 77 GNRISVVEG--------LENL----TNLEELHienqrlppgekltfdPRSLAALSnSLRVLNISGNNIDSLE--PLAPLR 142
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 75677612 938 FLKFINLSCNVITELS--FGTFQAWHgmqFLHKLILNHNPLTT 978
Cdd:cd21340 143 NLEQLDASNNQISDLEelLDLLSSWP---SLRELDLTGNPVCK 182
|
|
| rne |
PRK10811 |
ribonuclease E; Reviewed |
299-538 |
3.31e-05 |
|
ribonuclease E; Reviewed
Pssm-ID: 236766 [Multi-domain] Cd Length: 1068 Bit Score: 48.88 E-value: 3.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 299 VKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHElsiseqqqpvqpsessrevesspT 378
Cdd:PRK10811 848 VRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAE-----------------------P 904
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 379 QQETPGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTrlsgsgndveppaiqhgg 458
Cdd:PRK10811 905 QPEEVVVVETTHPEVIAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETA------------------ 966
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 459 PPLLPESSEEAGPLAVQQETsfqSPEPINNENPSPTQQEAAAEHPQTAEEGESSLTHQEAPAqtPEFpnvvVAQPPEHSH 538
Cdd:PRK10811 967 EVVVAEPEVVAQPAAPVVAE---VAAEVETVTAVEPEVAPAQVPEATVEHNHATAPMTRAPA--PEY----VPEAPRHSD 1037
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
49-383 |
8.70e-05 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 47.45 E-value: 8.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 49 LTSNPLGPPEPWSSHSSHfPRESPHAPtLPADPWDFdHLGPSaSSEMPAPPQestenlvPFLDTWDSA-GELPLEPEQFL 127
Cdd:pfam03154 249 LQPMTQPPPPSQVSPQPL-PQPSLHGQ-MPPMPHSL-QTGPS-HMQHPVPPQ-------PFPLTPQSSqSQVPPGPSPAA 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 128 ASQQDLKDKLSPQERLPVSPKKLKKDPAQRWSLA------EIIGIIHQLSTPQSQKQtlqneysstdtPYPGSLPPELRV 201
Cdd:pfam03154 318 PGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSmphikpPPTTPIPQLPNPQSHKH-----------PPHLSGPSPFQM 386
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 202 KSDEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPQLleeepssmqQEAPALPPESSMESLTLPNHEVS 281
Cdd:pfam03154 387 NSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVL---------TQSQSLPPPAASHPPTSGLHQVP 457
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 282 VQPPGEDQAYYHLPNITVKPAdvevtitSEPTNETESSQaqqeTPIQFPEEVEPSATQQ-EAPIEPPVPPME-HELSISE 359
Cdd:pfam03154 458 SQSPFPQHPFVPGGPPPITPP-------SGPPTSTSSAM----PGIQPPSSASVSSSGPvPAAVSCPLPPVQiKEEALDE 526
|
330 340
....*....|....*....|....
gi 75677612 360 QQQPVQPSESSREVESSPTQQETP 383
Cdd:pfam03154 527 AEEPESPPPPPRSPSPEPTVVNTP 550
|
|
| rne |
PRK10811 |
ribonuclease E; Reviewed |
223-593 |
1.13e-04 |
|
ribonuclease E; Reviewed
Pssm-ID: 236766 [Multi-domain] Cd Length: 1068 Bit Score: 46.96 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 223 ETQNPETLEDIQSSSLQQEAPAQLPQ-LLEEEPSSMQQEAPALPPEssmesltlpnHEVSVQPPGEDQAYYHLPNITVKP 301
Cdd:PRK10811 655 ESQQAEVTEKARTQDEQQQAPRRERQrRRNDEKRQAQQEAKALNVE----------EQSVQETEQEERVQQVQPRRKQRQ 724
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 302 ADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPmehELSISEQQQPVQpsessrevesspTQQE 381
Cdd:PRK10811 725 LNQKVRIEQSVAEEAVAPVVEETVAAEPVVQEVPAPRTELVKVPLPVVA---QTAPEQDEENNA------------ENRD 789
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 382 TPGQP------PEHHEV--------------TVSP-PghhQTHHLASPSVS----------VKPPDVQLTIAAEPSAEVG 430
Cdd:PRK10811 790 NNGMPrrsrrsPRHLRVsgqrrrryrderypTQSPmP---LTVACASPEMAsgkvwirypvVRPQDVQVEEQREAEEVQV 866
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 431 TSLVHqEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGPlAVQQETSFQSPEPIN---NENPSPTQQEAAAEHPQTAE 507
Cdd:PRK10811 867 QPVVA-EVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAEPQP-EEVVVVETTHPEVIAapvTEQPQVITESDVAVAQEVAE 944
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 508 EGESSLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPldlgfTITPESMTEVELSPTMKETPTQPPKKVVPQLRVYQG 587
Cdd:PRK10811 945 HAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPV-----VAEVAAEVETVTAVEPEVAPAQVPEATVEHNHATAP 1019
|
....*..
gi 75677612 588 VTN-PTP 593
Cdd:PRK10811 1020 MTRaPAP 1026
|
|
| rne |
PRK10811 |
ribonuclease E; Reviewed |
215-418 |
2.39e-04 |
|
ribonuclease E; Reviewed
Pssm-ID: 236766 [Multi-domain] Cd Length: 1068 Bit Score: 46.19 E-value: 2.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 215 PSQFHLEPETQNPETLEDIQSSSLQQEAPAQlpqllEEEPSSMQQEAPALPPEssmesltlPNHEVSVQPPGEDQAYYHL 294
Cdd:PRK10811 850 PQDVQVEEQREAEEVQVQPVVAEVPVAAAVE-----PVVSAPVVEAVAEVVEE--------PVVVAEPQPEEVVVVETTH 916
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 295 PNITVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPpmehelsisEQQQPVQPSESSREVE 374
Cdd:PRK10811 917 PEVIAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVA---------EPEVVAQPAAPVVAEV 987
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 75677612 375 SSPTQQETPGQPPEHHEVTVSPPGHHqtHHLASPSVSVKPPDVQ 418
Cdd:PRK10811 988 AAEVETVTAVEPEVAPAQVPEATVEH--NHATAPMTRAPAPEYV 1029
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
39-418 |
3.72e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 45.70 E-value: 3.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 39 PLEWVKDPLQLTSNPLGPPEPWSSHSSHFP---RESPHAPTLPADPwdfdhlGPSASSEMPAPPQESTENLVPFLDTWDS 115
Cdd:PHA03247 2694 SLTSLADPPPPPPTPEPAPHALVSATPLPPgpaAARQASPALPAAP------APPAVPAGPATPGGPARPARPPTTAGPP 2767
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 116 AGELPLEPEQFLASQQDLKDKLSPQERLPVSPkkLKKDPAQrwSLAEIIGIIHQLSTPQSQKQTLQNEYSSTDT------ 189
Cdd:PHA03247 2768 APAPPAAPAAGPPRRLTRPAVASLSESRESLP--SPWDPAD--PPAAVLAPAAALPPAASPAGPLPPPTSAQPTappppp 2843
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 190 -PYPGSLPPELRVKsdePPGPSEQVGPSQfhlePETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPSSMQQEAPALPPES 268
Cdd:PHA03247 2844 gPPPPSLPLGGSVA---PGGDVRRRPPSR----SPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPP 2916
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 269 SMESLTLPNHEvSVQPPGEDQAyyhLPNITVKPaDVEVTITSEPTNETESSQAQQETPIQFP---EEVEPSATQQEAPIE 345
Cdd:PHA03247 2917 PQPQPQPPPPP-QPQPPPPPPP---RPQPPLAP-TTDPAGAGEPSGAVPQPWLGALVPGRVAvprFRVPQPAPSREAPAS 2991
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 346 PPVPPMEHEL--------SISEQQQPVQPSESSREVESSPTQQE--------------------TPGQPPEHHEVTVSP- 396
Cdd:PHA03247 2992 STPPLTGHSLsrvsswasSLALHEETDPPPVSLKQTLWPPDDTEdsdadslfdsdsersdlealDPLPPEPHDPFAHEPd 3071
|
410 420
....*....|....*....|..
gi 75677612 397 PGHHQTHHLASPSVSVKPPDVQ 418
Cdd:PHA03247 3072 PATPEAGARESPSSQFGPPPLS 3093
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
914-954 |
9.00e-04 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 38.38 E-value: 9.00e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 75677612 914 SLQYLDLSCNKIQSIErhTFEPLPFLKFINLS-CNVITELSF 954
Cdd:pfam12799 2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSgNNKITDLSD 41
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
892-929 |
1.87e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 37.61 E-value: 1.87e-03
10 20 30
....*....|....*....|....*....|....*....
gi 75677612 892 EKLILRENNLTELhkDSFEGLLSLQYLDLS-CNKIQSIE 929
Cdd:pfam12799 4 EVLDLSNNQITDI--PPLAKLPNLETLDLSgNNKITDLS 40
|
|
| PRK14949 |
PRK14949 |
DNA polymerase III subunits gamma and tau; Provisional |
197-602 |
3.68e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237863 [Multi-domain] Cd Length: 944 Bit Score: 42.02 E-value: 3.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 197 PELRVKSDEPPGPSEQVGPSQFHLEP-ETQNPETLEDIQSSSLQqeAPAQLPQLLEEEPSSMQQEAPALPPESSMESLTL 275
Cdd:PRK14949 359 PEKPVKRWQVDDPAEISLPEGQTPSAlAAAVQAPHANEPQFVNA--APAEKKTALTEQTTAQQQVQAANAEAVAEADASA 436
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 276 PNHEVSVQPPGED--------------------QAYYHLPNITVKP-ADVEVTITSEPTNETESS------QAQQETPIQ 328
Cdd:PRK14949 437 EPADTVEQALDDEsellaalnaeqavilsqaqsQGFEASSSLDADNsAVPEQIDSTAEQSVVNPSvtdtqvDDTSASNNS 516
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 329 FPEEVEPSATQQEAPIEPpvppmeHELSISEQQQPVQPSESSREVESSPTQQETPGQPPEHHEVTVSPPGHHQthHLASP 408
Cdd:PRK14949 517 AADNTVDDNYSAEDTLES------NGLDEGDYAQDSAPLDAYQDDYVAFSSESYNALSDDEQHSANVQSAQSA--AEAQP 588
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 409 SVSVKPPDVQLTIAAEPSAE-----------------VGTSLVHQEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGP 471
Cdd:PRK14949 589 SSQSLSPISAVTTAAASLADddildavlaardsllsdLDALSPKEGDGKKSSADRKPKTPPSRAPPASLSKPASSPDASQ 668
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 472 LAVQQETSFQS-PEPINNENPSPTQ-QEAAAEHPQT----------AEEGESSLTHQEAPAQTPEFPNVV---------V 530
Cdd:PRK14949 669 TSASFDLDPDFeLATHQSVPEAALAsGSAPAPPPVPdpydrppweeAPEVASANDGPNNAAEGNLSESVEdasnselqaV 748
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75677612 531 AQPPEHSHLTQATVQPldlgftitpesmtevelsPTMKETPTQPPKKVVPQlrvyQGVTNPTPGQDQAQHPV 602
Cdd:PRK14949 749 EQQATHQPQVQAEAQS------------------PASTTALTQTSSEVQDT----ELNLVLLSSGSITGHPL 798
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
891-976 |
5.35e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 40.80 E-value: 5.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 891 TEKLILRENNLTELH-KDSFEGL---LSLQYLDLSCNKIQSIER------HTFEPLPFLKFINLSCNVITELSFGTFQAW 960
Cdd:cd00116 25 LQVLRLEGNTLGEEAaKALASALrpqPSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDGCGVLESL 104
|
90
....*....|....*.
gi 75677612 961 HGMQFLHKLILNHNPL 976
Cdd:cd00116 105 LRSSSLQELKLNNNGL 120
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
438-785 |
7.38e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 41.22 E-value: 7.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 438 ATTRLSGSGNDVEPpaIQHGGPPLLPESSEEAGPLAVQQETSFQSPEPINNENPsptqqEAAAEHPQTAEEGESSLTHQE 517
Cdd:PRK10263 326 ATTATQSWAAPVEP--VTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAP-----EGYPQQSQYAQPAVQYNEPLQ 398
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 518 APAQTPEFPNVVVAQPPEHSHLTQATVQPLDLGFTITPESMTEVELSPTMKEtPTQPPKKVVPQLRVYQGVTNPTPG--Q 595
Cdd:PRK10263 399 QPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAE-EQQSTFAPQSTYQTEQTYQQPAAQepL 477
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 596 DQAQHPVSPSVTVQlldlgltitPEPTTEvghSTPPKRTivspkhPEVTLPHPDQVQTQHSHLTRATVQPLdlgftitPK 675
Cdd:PRK10263 478 YQQPQPVEQQPVVE---------PEPVVE---ETKPARP------PLYYFEEVEEKRAREREQLAAWYQPI-------PE 532
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612 676 SMTEVEPSTALMTTAPPPGHPEVTlppsdkgqaqhshlTQATVQPLDLELTITTkpttevkpSPTTEETSTQLPDLGLAI 755
Cdd:PRK10263 533 PVKEPEPIKSSLKAPSVAAVPPVE--------------AAAAVSPLASGVKKAT--------LATGAAATVAAPVFSLAN 590
|
330 340 350
....*....|....*....|....*....|..
gi 75677612 756 --IPEPTTETGHSTALekttaPRPDRVQTLHR 785
Cdd:PRK10263 591 sgGPRPQVKEGIGPQL-----PRPKRIRVPTR 617
|
|
|