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Conserved domains on  [gi|40805825|ref|NP_955474|]
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coatomer subunit epsilon isoform b [Homo sapiens]

Protein Classification

coatomer subunit epsilon( domain architecture ID 707680)

coatomer subunit epsilon, a component of the coatomer complex, which is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins

CATH:  1.25.40.10
Gene Ontology:  GO:0015031|GO:0005198|GO:0006888
SCOP:  4001344

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Coatomer_E super family cl28726
Coatomer epsilon subunit; This family represents the epsilon subunit of the coatomer complex, ...
 17-254 7.62e-122

Coatomer epsilon subunit; This family represents the epsilon subunit of the coatomer complex, which is involved in the regulation of intracellular protein trafficking between the endoplasmic reticulum and the Golgi complex.


The actual alignment was detected with superfamily member pfam04733:

Pssm-ID: 398419 [Multi-domain]  Cd Length: 288  Bit Score: 348.70  E-value: 7.62e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825    17 DELFDVKNAFYIGSYQQCINEAQrVKLSSPERDVERDVFLYRAYLAQRKFGVVLDEIKPSSAPELQAVRMFADYLAHESR 96
Cdd:pfam04733   1 DELFNVRNYFYLGNYQKAINESD-VTSLSEEALVERDVYMYRSYLALGSYQIVISEIKESAATPLQAVRLLAEYLNSPSR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825    97 ---------------------------------------------------STAMTVQILLKLDRLDLARKELKRMQDLD 125
Cdd:pfam04733  80 kesilaslkewvadshigsnstlrllaaiifihegdfddalkhlhkgenleAMALNVQILLKMHRIDLAEQQLKKMQQID 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825   126 EDATLTQLATAWVSLATGGEKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWEAAEGLLQEALDKDSGYPETLVNL 205
Cdd:pfam04733 160 EDATLTQLANAWVKLAVGGEKIQDAYYIFQEFSEKYDSTPLLLNGQAVCCMCLGRYEEAESLLKEALDKDAKDPETLINL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 40805825   206 IVLSQHLGKPPEVTNRYLSQLKDAHRSHPFIKEYQAKENDFDRLVLQYA 254
Cdd:pfam04733 240 VVCALHLGKPAEVSNRNLSQLKLSHPTHPLVKDLNEKEAEFDRAVQQFA 288
 
Name Accession Description Interval E-value
Coatomer_E pfam04733
Coatomer epsilon subunit; This family represents the epsilon subunit of the coatomer complex, ...
 17-254 7.62e-122

Coatomer epsilon subunit; This family represents the epsilon subunit of the coatomer complex, which is involved in the regulation of intracellular protein trafficking between the endoplasmic reticulum and the Golgi complex.


Pssm-ID: 398419 [Multi-domain]  Cd Length: 288  Bit Score: 348.70  E-value: 7.62e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825    17 DELFDVKNAFYIGSYQQCINEAQrVKLSSPERDVERDVFLYRAYLAQRKFGVVLDEIKPSSAPELQAVRMFADYLAHESR 96
Cdd:pfam04733   1 DELFNVRNYFYLGNYQKAINESD-VTSLSEEALVERDVYMYRSYLALGSYQIVISEIKESAATPLQAVRLLAEYLNSPSR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825    97 ---------------------------------------------------STAMTVQILLKLDRLDLARKELKRMQDLD 125
Cdd:pfam04733  80 kesilaslkewvadshigsnstlrllaaiifihegdfddalkhlhkgenleAMALNVQILLKMHRIDLAEQQLKKMQQID 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825   126 EDATLTQLATAWVSLATGGEKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWEAAEGLLQEALDKDSGYPETLVNL 205
Cdd:pfam04733 160 EDATLTQLANAWVKLAVGGEKIQDAYYIFQEFSEKYDSTPLLLNGQAVCCMCLGRYEEAESLLKEALDKDAKDPETLINL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 40805825   206 IVLSQHLGKPPEVTNRYLSQLKDAHRSHPFIKEYQAKENDFDRLVLQYA 254
Cdd:pfam04733 240 VVCALHLGKPAEVSNRNLSQLKLSHPTHPLVKDLNEKEAEFDRAVQQFA 288
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 103-234 3.23e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.57  E-value: 3.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825 103 QILLKLDRLDLARKELKRMQDLDEDATLTQLATAWVSLATGgeKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWE 182
Cdd:COG4783  12 QALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLG--DLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYD 89

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 40805825 183 AAEGLLQEALDKDSGYPETLVNLIVLSQHLGKPPEvtnrYLSQLKDAHRSHP 234
Cdd:COG4783  90 EALALLEKALKLDPEHPEAYLRLARAYRALGRPDE----AIAALEKALELDP 137
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 56-256 8.03e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.45  E-value: 8.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825    56 LYRAYLAQRKFGVVLDEikpSSAPELQAVRMFADYLAHesRSTAMtvqilLKLDRLDLARKELKRMQDLDEDATLTQLAT 135
Cdd:TIGR02917  96 LARAYLLQGKFQQVLDE---LPGKTLLDDEGAAELLAL--RGLAY-----LGLGQLELAQKSYEQALAIDPRSLYAKLGL 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825   136 AWVSLATGgeKLQDAYYIFQEM--ADKCSPTLLLLNGQAAchMAQGRWEAAEGLLQEALDKDSGYPETLVNLIVLSQHLG 213
Cdd:TIGR02917 166 AQLALAEN--RFDEARALIDEVltADPGNVDALLLKGDLL--LSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAG 241

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 40805825   214 KpPEVTNRYLSQLKDAHRSHPFIKEYQA----KENDFDRL------VLQYAPS 256
Cdd:TIGR02917 242 E-FEEAEKHADALLKKAPNSPLAHYLKAlvdfQKKNYEDAretlqdALKSAPE 293
 
Name Accession Description Interval E-value
Coatomer_E pfam04733
Coatomer epsilon subunit; This family represents the epsilon subunit of the coatomer complex, ...
 17-254 7.62e-122

Coatomer epsilon subunit; This family represents the epsilon subunit of the coatomer complex, which is involved in the regulation of intracellular protein trafficking between the endoplasmic reticulum and the Golgi complex.


Pssm-ID: 398419 [Multi-domain]  Cd Length: 288  Bit Score: 348.70  E-value: 7.62e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825    17 DELFDVKNAFYIGSYQQCINEAQrVKLSSPERDVERDVFLYRAYLAQRKFGVVLDEIKPSSAPELQAVRMFADYLAHESR 96
Cdd:pfam04733   1 DELFNVRNYFYLGNYQKAINESD-VTSLSEEALVERDVYMYRSYLALGSYQIVISEIKESAATPLQAVRLLAEYLNSPSR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825    97 ---------------------------------------------------STAMTVQILLKLDRLDLARKELKRMQDLD 125
Cdd:pfam04733  80 kesilaslkewvadshigsnstlrllaaiifihegdfddalkhlhkgenleAMALNVQILLKMHRIDLAEQQLKKMQQID 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825   126 EDATLTQLATAWVSLATGGEKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWEAAEGLLQEALDKDSGYPETLVNL 205
Cdd:pfam04733 160 EDATLTQLANAWVKLAVGGEKIQDAYYIFQEFSEKYDSTPLLLNGQAVCCMCLGRYEEAESLLKEALDKDAKDPETLINL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 40805825   206 IVLSQHLGKPPEVTNRYLSQLKDAHRSHPFIKEYQAKENDFDRLVLQYA 254
Cdd:pfam04733 240 VVCALHLGKPAEVSNRNLSQLKLSHPTHPLVKDLNEKEAEFDRAVQQFA 288
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 103-234 3.23e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.57  E-value: 3.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825 103 QILLKLDRLDLARKELKRMQDLDEDATLTQLATAWVSLATGgeKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWE 182
Cdd:COG4783  12 QALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLG--DLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYD 89

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 40805825 183 AAEGLLQEALDKDSGYPETLVNLIVLSQHLGKPPEvtnrYLSQLKDAHRSHP 234
Cdd:COG4783  90 EALALLEKALKLDPEHPEAYLRLARAYRALGRPDE----AIAALEKALELDP 137
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 103-217 2.31e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.37  E-value: 2.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825 103 QILLKLDRLDLARKELKRMQDLDEDATLTQLATAWVSLATGgeKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWE 182
Cdd:COG3914  86 LLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALG--RLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLE 163

                        90       100       110
                ....*....|....*....|....*....|....*
gi 40805825 183 AAEGLLQEALDKDSGYPETLVNLIVLSQHLGKPPE 217
Cdd:COG3914 164 EAIAALRRALELDPDNAEALNNLGNALQDLGRLEE 198
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 82-253 2.96e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 2.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825  82 QAVRMFADYLAHESRSTAMTV---QILLKLDRLDLARKELKRMQDLDEDA--TLTQLATAWVSLatggEKLQDAYYIFQE 156
Cdd:COG2956  60 RAIRIHQKLLERDPDRAEALLelaQDYLKAGLLDRAEELLEKLLELDPDDaeALRLLAEIYEQE----GDWEKAIEVLER 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825 157 MADKCSPTLLLLNGQAACHMAQGRWEAAEGLLQEALDKDSGYPETLVNLIVLSQHLGKPPEVTNRYLSQLK---DAHRSH 233
Cdd:COG2956 136 LLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEqdpDYLPAL 215

                       170       180
                ....*....|....*....|
gi 40805825 234 PFIKEYQAKENDFDRLVLQY 253
Cdd:COG2956 216 PRLAELYEKLGDPEEALELL 235
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 103-227 3.46e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.95  E-value: 3.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825 103 QILLKLDRLDLARKELKRMQDLDEDATLTQLATAWVSLATGgeKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWE 182
Cdd:COG2956 152 ELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQG--DYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPE 229

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 40805825 183 AAEGLLQEALDKDSGYPEtLVNLIVLSQHLGKPPEVTNRYLSQLK 227
Cdd:COG2956 230 EALELLRKALELDPSDDL-LLALADLLERKEGLEAALALLERQLR 273
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 103-217 1.14e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.41  E-value: 1.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825 103 QILLKLDRLDLARKELKRMQDLDEDATLTQLATAWVSLATGgeKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWE 182
Cdd:COG2956  16 LNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRG--EYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLD 93

                        90       100       110
                ....*....|....*....|....*....|....*
gi 40805825 183 AAEGLLQEALDKDSGYPETLVNLIVLSQHLGKPPE 217
Cdd:COG2956  94 RAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEK 128
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 102-234 4.24e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.87  E-value: 4.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825 102 VQILLKLDRLDLARKELKRMQDLDEDATLTQLATAWVSLATGGEKLQDAYYIF-QEMADKCSPTLLLLngqAACHMAQGR 180
Cdd:COG2956 117 AEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKaLKLDPDCARALLLL---AELYLEQGD 193

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 40805825 181 WEAAEGLLQEALDKDSGYPETLVNLIVLSQHLGKPPEvtnrYLSQLKDAHRSHP 234
Cdd:COG2956 194 YEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEE----ALELLRKALELDP 243
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 48-217 5.28e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.13  E-value: 5.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825  48 RDVERDVFLYRAYLAQRKFGVVLDEIKPSSAPELQAVRMFADYLAHESRSTAMTVQILLKLDRLDLARKELKRMQDLDED 127
Cdd:COG3914   5 ALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825 128 ATLTQLAtawvslatggEKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWEAAEGLLQEALDKDSGYPETLVNLIV 207
Cdd:COG3914  85 ALLLQAL----------GRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGE 154

                       170
                ....*....|
gi 40805825 208 LSQHLGKPPE 217
Cdd:COG3914 155 ALRRLGRLEE 164
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 56-256 8.03e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.45  E-value: 8.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825    56 LYRAYLAQRKFGVVLDEikpSSAPELQAVRMFADYLAHesRSTAMtvqilLKLDRLDLARKELKRMQDLDEDATLTQLAT 135
Cdd:TIGR02917  96 LARAYLLQGKFQQVLDE---LPGKTLLDDEGAAELLAL--RGLAY-----LGLGQLELAQKSYEQALAIDPRSLYAKLGL 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825   136 AWVSLATGgeKLQDAYYIFQEM--ADKCSPTLLLLNGQAAchMAQGRWEAAEGLLQEALDKDSGYPETLVNLIVLSQHLG 213
Cdd:TIGR02917 166 AQLALAEN--RFDEARALIDEVltADPGNVDALLLKGDLL--LSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAG 241

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 40805825   214 KpPEVTNRYLSQLKDAHRSHPFIKEYQA----KENDFDRL------VLQYAPS 256
Cdd:TIGR02917 242 E-FEEAEKHADALLKKAPNSPLAHYLKAlvdfQKKNYEDAretlqdALKSAPE 293
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
104-217 1.59e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.83  E-value: 1.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825 104 ILLKLDRLDLARKELKRMQDLDED--ATLTQLATAWVSLatggEKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRW 181
Cdd:COG0457  17 AYRRLGRYEEAIEDYEKALELDPDdaEALYNLGLAYLRL----GRYEEALADYEQALELDPDDAEALNNLGLALQALGRY 92

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 40805825 182 EAAEGLLQEALDKDSGYPETLVNLIVLSQHLGKPPE 217
Cdd:COG0457  93 EEALEDYDKALELDPDDAEALYNLGLALLELGRYDE 128
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 114-256 2.18e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825   114 ARKELKRMQDLDEDATLTQLATAWVSLATggEKLQDAYYIFQEMADK--CSPTLLLLNGQAacHMAQGRWEAAEGLLQEA 191
Cdd:TIGR02917 654 AITSLKRALELKPDNTEAQIGLAQLLLAA--KRTESAKKIAKSLQKQhpKAALGFELEGDL--YLRQKDYPAAIQAYRKA 729

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 40805825   192 LDKDSGyPETLVNL-IVLSQhLGKPPEVTNRYLSQLKDaHRSHPFIKEYQA----KENDFD------RLVLQYAPS 256
Cdd:TIGR02917 730 LKRAPS-SQNAIKLhRALLA-SGNTAEAVKTLEAWLKT-HPNDAVLRTALAelylAQKDYDkaikhyQTVVKKAPD 802
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 78-217 4.86e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 36.86  E-value: 4.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825  78 APELQAVRMFADYLAHESRSTAMTVQILLKLDRLDLARKELKRMQDLDEDATLTQLATAWVSLATGGEKLQDAYYIFQEM 157
Cdd:COG5010   1 ARALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQA 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825 158 ADKCSPTLLLLNGQAACHMAQGRWEAAEGLLQEALDKDSGYPETLVNLIVLSQHLGKPPE 217
Cdd:COG5010  81 LQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDE 140
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
103-254 5.97e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 37.29  E-value: 5.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805825 103 QILLKLDRLDLARKELKRMQDLDEDATLTQLATAWVSLATGgeKLQDAYYIFQEmADKCSPTLL-LLNGQAACHMAQGRW 181
Cdd:COG0457  50 LAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALG--RYEEALEDYDK-ALELDPDDAeALYNLGLALLELGRY 126

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40805825 182 EAAEGLLQEALDKDSGYPETLVNLIVLSQHLGKPPEVTNRYLSQLKDAHRSHPFIKEYQAKENDFDRLVLQYA 254
Cdd:COG0457 127 DEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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