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Conserved domains on  [gi|41327708|ref|NP_957705|]
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protein crumbs homolog 1 isoform 1 precursor [Homo sapiens]

Protein Classification

EGF_CA and LamG domain-containing protein( domain architecture ID 10810790)

EGF_CA and LamG domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 514-649 1.64e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.41  E-value: 1.64e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708    514 FQTVQPMALLLFRSN-RDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEV-IFAEAVTLTLIDDSCKEKC 591
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVeRNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 41327708    592 IAKAPTPLESDQSIcafqnsFLGGLPvgmtsngvALLNFYNMPSTPSFVGCLQDIKID 649
Cdd:pfam02210   81 PPGESLLLNLNGPL------YLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 743-860 1.19e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 83.24  E-value: 1.19e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708    743 VRTLQPSGLLLALENSTYQYIRVWLERGRLAML--TPNSPKLVV--KFVLNDGNVHLISLKIKPYKIELYQSSQNLGFIS 818
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRydLGSGPESLLssGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 41327708    819 ASTWK--IEKGDVIYIGGLP--DKQETELNGGFFKGCIQDVRLNNQ 860
Cdd:pfam02210   81 PPGESllLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 980-1105 4.48e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 81.70  E-value: 4.48e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708    980 FRTRDANVIILHAE-KEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSlQSVNDGTWHEVTLSMTDplsqtSRWQMEVDNE 1058
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSG-KNLNDGQWHSVRVERNG-----NTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 41327708   1059 TpfVTSTIATGSLNFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEIGGI 1105
Cdd:pfam02210   75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 148-183 1.02e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.02e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 41327708  148 DHDECAS-SPCQNGAVCQDGIDGYSCFCVPGYQGRHC 183
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
397-438 3.59e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.63  E-value: 3.59e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 41327708     397 DVNECSS-NPCQNGGTCENLPGNYTCHCPfdnlsRTFYGGRDC 438
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 187-222 6.18e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 6.18e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 41327708  187 VDECAS-DPCKNEATCLNEIGRYTCICPHNYSGVNCE 222
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 225-260 6.96e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 6.96e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 41327708  225 IDEC-WSQPCLNGATCQDALGAYFCDCAPGFLGDHCE 260
Cdd:cd00054    2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 72-108 7.76e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 7.76e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 41327708   72 DPCFS-NPCQGSATCVNTPGerSFLCKCPPGYSGTICE 108
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVG--SYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1146-1175 9.63e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 9.63e-06
                         10        20        30
                 ....*....|....*....|....*....|
gi 41327708 1146 NPCLHGGNCEDIYSSYHCSCPLGWSGKHCE 1175
Cdd:cd00054    9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1297-1333 1.75e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.75e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 41327708 1297 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAFAGERCE 1333
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 262-299 4.72e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.72e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 41327708  262 NTDECASQ-PCLHGGLCVDGENRYSCNCTgSGFTGTHCE 299
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1177-1212 6.16e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 6.16e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 41327708 1177 NIDECFS-NPC-IHGNCSDRVAAYHCTCEPGYTGVNCE 1212
Cdd:cd00054    1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 309-337 1.83e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.83e-04
                         10        20
                 ....*....|....*....|....*....
gi 41327708  309 PCHNNATCEDSVDNYTCHCWPGYTGAQCE 337
Cdd:cd00054   10 PCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1214-1249 7.48e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 7.48e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 41327708 1214 DIDNCQS-HQCANGATCISHTNGYSCLCFGNFTGKFC 1249
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 676-707 1.13e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.13e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 41327708  676 CESQ-PCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Cdd:cd00054    5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 889-923 1.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.92e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 41327708  889 NSCKS-NPCHNGGVCHSRWDDFSCSCPALTSGKACE 923
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 339-395 9.97e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 9.97e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 41327708  339 DLNECNS-NPCQSNGECVELssekqygritglpssfsyheASGYVCICQPGFTGIHCE 395
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNT--------------------VGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 514-649 1.64e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.41  E-value: 1.64e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708    514 FQTVQPMALLLFRSN-RDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEV-IFAEAVTLTLIDDSCKEKC 591
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVeRNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 41327708    592 IAKAPTPLESDQSIcafqnsFLGGLPvgmtsngvALLNFYNMPSTPSFVGCLQDIKID 649
Cdd:pfam02210   81 PPGESLLLNLNGPL------YLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 743-860 1.19e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 83.24  E-value: 1.19e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708    743 VRTLQPSGLLLALENSTYQYIRVWLERGRLAML--TPNSPKLVV--KFVLNDGNVHLISLKIKPYKIELYQSSQNLGFIS 818
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRydLGSGPESLLssGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 41327708    819 ASTWK--IEKGDVIYIGGLP--DKQETELNGGFFKGCIQDVRLNNQ 860
Cdd:pfam02210   81 PPGESllLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 980-1105 4.48e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 81.70  E-value: 4.48e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708    980 FRTRDANVIILHAE-KEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSlQSVNDGTWHEVTLSMTDplsqtSRWQMEVDNE 1058
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSG-KNLNDGQWHSVRVERNG-----NTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 41327708   1059 TpfVTSTIATGSLNFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEIGGI 1105
Cdd:pfam02210   75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 485-649 1.36e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 81.31  E-value: 1.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708  485 TLSFEGDGFLWVKSGSVTTKGSvcNIALRFQTVQPMALLLF--RSNRDVFVKLELLSGYIHLSiqVNNQSKVLLFISHNT 562
Cdd:cd00110    1 GVSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYagSQNGGDFLALELEDGRLVLR--YDLGSGSLVLSSKTP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708  563 -SDGEWHFVEVIfAEAVTLTLIDDSCK--EKCIAKAPTPLESDQSIcafqnsFLGGLPVGMTSNGVallnfynmPSTPSF 639
Cdd:cd00110   77 lNDGQWHSVSVE-RNGRSVTLSVDGERvvESGSPGGSALLNLDGPL------YLGGLPEDLKSPGL--------PVSPGF 141

                        170
                 ....*....|
gi 41327708  640 VGCLQDIKID 649
Cdd:cd00110  142 VGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 952-1102 1.07e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 78.61  E-value: 1.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708  952 AVFNGQSGqILFRSNGNITRElTNITFGFRTRDANVIILHAEKEP--EFLNISIQDSRLFFQLQSGNSfyMLSLTSLQSV 1029
Cdd:cd00110    2 VSFSGSSY-VRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGSG--SLVLSSKTPL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708 1030 NDGTWHEVTLSMtdplsQTSRWQMEVDNEtPFVTSTIATGSLnFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEI 1102
Cdd:cd00110   78 NDGQWHSVSVER-----NGRSVTLSVDGE-RVVESGSPGGSA-LLNLDGPLYLGglpedlkSPGLPVSPGFVGCIRDLKV 150
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 720-858 3.92e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.07  E-value: 3.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708  720 DSTGYVIFTLDESYGDTISLSMFVRTLQPSGLLLALENSTY-QYIRVWLERGRLAM---LTPNSPKLVVKFVLNDGNVHL 795
Cdd:cd00110    5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALELEDGRLVLrydLGSGSLVLSSKTPLNDGQWHS 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41327708  796 ISLKIKPYKIELY--QSSQNLGFISASTWKIEKGDVIYIGGLPD--KQETELNGGFFKGCIQDVRLN 858
Cdd:cd00110   85 VSVERNGRSVTLSvdGERVVESGSPGGSALLNLDGPLYLGGLPEdlKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
975-1104 1.58e-15

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 74.68  E-value: 1.58e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708     975 NITFGFRTRDANVIILHA--EKEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSlQSVNDGTWHEVTLSMTDplsqtSRWQ 1052
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDP-TPLNDGQWHRVAVERNG-----RSVT 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 41327708    1053 MEVDNETPfvTSTIATGSLNFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEIGG 1104
Cdd:smart00282   75 LSVDGGNR--VSGESPGGLTILNLDGPLYLGglpedlkLPPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
509-649 3.71e-14

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 70.83  E-value: 3.71e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708     509 NIALRFQTVQPMALLLF--RSNRDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVIfAEAVTLTLIDDS 586
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVE-RNGRSVTLSVDG 79

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41327708     587 CKEKcIAKAP---TPLESDQSIcafqnsFLGGLPVGMTSNGVallnfynmPSTPSFVGCLQDIKID 649
Cdd:smart00282   80 GNRV-SGESPgglTILNLDGPL------YLGGLPEDLKLPPL--------PVTPGFRGCIRNLKVN 130
LamG smart00282
Laminin G domain;
738-860 1.12e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 66.59  E-value: 1.12e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708     738 SLSMFVRTLQPSGLLLALENSTY-QYIRVWLERGRL-AMLTPNSPKLVVK---FVLNDGNVHLISLKIKPYKIELY--QS 810
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLvLRYDLGSGPARLTsdpTPLNDGQWHRVAVERNGRSVTLSvdGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 41327708     811 SQNLGFISASTWKIEKGDVIYIGGLPD--KQETELNGGFFKGCIQDVRLNNQ 860
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEdlKLPPLPVTPGFRGCIRNLKVNGK 132
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 148-183 1.02e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.02e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 41327708  148 DHDECAS-SPCQNGAVCQDGIDGYSCFCVPGYQGRHC 183
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
397-438 3.59e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.63  E-value: 3.59e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 41327708     397 DVNECSS-NPCQNGGTCENLPGNYTCHCPfdnlsRTFYGGRDC 438
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 187-222 6.18e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 6.18e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 41327708  187 VDECAS-DPCKNEATCLNEIGRYTCICPHNYSGVNCE 222
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 397-424 2.41e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 2.41e-06
                         10        20
                 ....*....|....*....|....*....
gi 41327708  397 DVNECSS-NPCQNGGTCENLPGNYTCHCP 424
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCP 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
148-184 2.70e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.70e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 41327708     148 DHDECAS-SPCQNGAVCQDGIDGYSCFCVPGYQ-GRHCD 184
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 225-260 6.96e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 6.96e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 41327708  225 IDEC-WSQPCLNGATCQDALGAYFCDCAPGFLGDHCE 260
Cdd:cd00054    2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 72-108 7.76e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 7.76e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 41327708   72 DPCFS-NPCQGSATCVNTPGerSFLCKCPPGYSGTICE 108
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVG--SYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1146-1175 9.63e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 9.63e-06
                         10        20        30
                 ....*....|....*....|....*....|
gi 41327708 1146 NPCLHGGNCEDIYSSYHCSCPLGWSGKHCE 1175
Cdd:cd00054    9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1297-1333 1.75e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.75e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 41327708 1297 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAFAGERCE 1333
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
186-222 2.66e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.66e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 41327708     186 EVDECAS-DPCKNEATCLNEIGRYTCICPHNYS-GVNCE 222
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1143-1173 3.72e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.72e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 41327708   1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKH 1173
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 262-299 4.72e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.72e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 41327708  262 NTDECASQ-PCLHGGLCVDGENRYSCNCTgSGFTGTHCE 299
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1177-1212 6.16e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 6.16e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 41327708 1177 NIDECFS-NPC-IHGNCSDRVAAYHCTCEPGYTGVNCE 1212
Cdd:cd00054    1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 309-337 1.83e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.83e-04
                         10        20
                 ....*....|....*....|....*....
gi 41327708  309 PCHNNATCEDSVDNYTCHCWPGYTGAQCE 337
Cdd:cd00054   10 PCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
224-260 1.86e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 1.86e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 41327708     224 EIDECWS-QPCLNGATCQDALGAYFCDCAPGF-LGDHCE 260
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 401-424 2.70e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 2.70e-04
                           10        20
                   ....*....|....*....|....
gi 41327708    401 CSSNPCQNGGTCENLPGNYTCHCP 424
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP 24
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 152-182 3.32e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 3.32e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 41327708    152 CASSPCQNGAVCQDGIDGYSCFCVPGYQGRH 182
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 190-220 3.35e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 3.35e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 41327708    190 CASDPCKNEATCLNEIGRYTCICPHNYSGVN 220
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1297-1333 3.67e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 3.67e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 41327708    1297 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAF-AGERCE 1333
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
77-108 5.18e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 5.18e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 41327708      77 NPCQGSATCVNTPGerSFLCKCPPGYS-GTICE 108
Cdd:smart00179    9 NPCQNGGTCVNTVG--SYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1146-1175 5.49e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 5.49e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 41327708    1146 NPCLHGGNCEDIYSSYHCSCPLGWS-GKHCE 1175
Cdd:smart00179    9 NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1214-1249 7.48e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 7.48e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 41327708 1214 DIDNCQS-HQCANGATCISHTNGYSCLCFGNFTGKFC 1249
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 676-707 1.13e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.13e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 41327708  676 CESQ-PCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Cdd:cd00054    5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
309-337 1.59e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.59e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 41327708     309 PCHNNATCEDSVDNYTCHCWPGYT-GAQCE 337
Cdd:smart00179   10 PCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 889-923 1.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.92e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 41327708  889 NSCKS-NPCHNGGVCHSRWDDFSCSCPALTSGKACE 923
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1177-1212 2.70e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.70e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 41327708    1177 NIDECFS-NPCIHG-NCSDRVAAYHCTCEPGYT-GVNCE 1212
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
262-299 2.76e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.76e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 41327708     262 NTDECAS-QPCLHGGLCVDGENRYSCNCtGSGFT-GTHCE 299
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCEC-PPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 74-104 3.15e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 3.15e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 41327708     74 CFSNPCQGSATCVNTPGerSFLCKCPPGYSG 104
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPG--GYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 266-295 5.41e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 5.41e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 41327708    266 CASQPCLHGGLCVDGENRYSCNCTgSGFTG 295
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 676-706 6.40e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 6.40e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 41327708    676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPN 706
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 228-258 6.53e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 6.53e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 41327708    228 CWSQPCLNGATCQDALGAYFCDCAPGFLGDH 258
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 891-920 9.77e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 9.77e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 41327708    891 CKSNPCHNGGVCHSRWDDFSCSCPALTSGK 920
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 339-395 9.97e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 9.97e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 41327708  339 DLNECNS-NPCQSNGECVELssekqygritglpssfsyheASGYVCICQPGFTGIHCE 395
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNT--------------------VGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 514-649 1.64e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.41  E-value: 1.64e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708    514 FQTVQPMALLLFRSN-RDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEV-IFAEAVTLTLIDDSCKEKC 591
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVeRNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 41327708    592 IAKAPTPLESDQSIcafqnsFLGGLPvgmtsngvALLNFYNMPSTPSFVGCLQDIKID 649
Cdd:pfam02210   81 PPGESLLLNLNGPL------YLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 743-860 1.19e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 83.24  E-value: 1.19e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708    743 VRTLQPSGLLLALENSTYQYIRVWLERGRLAML--TPNSPKLVV--KFVLNDGNVHLISLKIKPYKIELYQSSQNLGFIS 818
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRydLGSGPESLLssGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 41327708    819 ASTWK--IEKGDVIYIGGLP--DKQETELNGGFFKGCIQDVRLNNQ 860
Cdd:pfam02210   81 PPGESllLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 980-1105 4.48e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 81.70  E-value: 4.48e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708    980 FRTRDANVIILHAE-KEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSlQSVNDGTWHEVTLSMTDplsqtSRWQMEVDNE 1058
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSG-KNLNDGQWHSVRVERNG-----NTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 41327708   1059 TpfVTSTIATGSLNFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEIGGI 1105
Cdd:pfam02210   75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 485-649 1.36e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 81.31  E-value: 1.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708  485 TLSFEGDGFLWVKSGSVTTKGSvcNIALRFQTVQPMALLLF--RSNRDVFVKLELLSGYIHLSiqVNNQSKVLLFISHNT 562
Cdd:cd00110    1 GVSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYagSQNGGDFLALELEDGRLVLR--YDLGSGSLVLSSKTP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708  563 -SDGEWHFVEVIfAEAVTLTLIDDSCK--EKCIAKAPTPLESDQSIcafqnsFLGGLPVGMTSNGVallnfynmPSTPSF 639
Cdd:cd00110   77 lNDGQWHSVSVE-RNGRSVTLSVDGERvvESGSPGGSALLNLDGPL------YLGGLPEDLKSPGL--------PVSPGF 141

                        170
                 ....*....|
gi 41327708  640 VGCLQDIKID 649
Cdd:cd00110  142 VGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 952-1102 1.07e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 78.61  E-value: 1.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708  952 AVFNGQSGqILFRSNGNITRElTNITFGFRTRDANVIILHAEKEP--EFLNISIQDSRLFFQLQSGNSfyMLSLTSLQSV 1029
Cdd:cd00110    2 VSFSGSSY-VRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGSG--SLVLSSKTPL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708 1030 NDGTWHEVTLSMtdplsQTSRWQMEVDNEtPFVTSTIATGSLnFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEI 1102
Cdd:cd00110   78 NDGQWHSVSVER-----NGRSVTLSVDGE-RVVESGSPGGSA-LLNLDGPLYLGglpedlkSPGLPVSPGFVGCIRDLKV 150
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 720-858 3.92e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.07  E-value: 3.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708  720 DSTGYVIFTLDESYGDTISLSMFVRTLQPSGLLLALENSTY-QYIRVWLERGRLAM---LTPNSPKLVVKFVLNDGNVHL 795
Cdd:cd00110    5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALELEDGRLVLrydLGSGSLVLSSKTPLNDGQWHS 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41327708  796 ISLKIKPYKIELY--QSSQNLGFISASTWKIEKGDVIYIGGLPD--KQETELNGGFFKGCIQDVRLN 858
Cdd:cd00110   85 VSVERNGRSVTLSvdGERVVESGSPGGSALLNLDGPLYLGGLPEdlKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
975-1104 1.58e-15

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 74.68  E-value: 1.58e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708     975 NITFGFRTRDANVIILHA--EKEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSlQSVNDGTWHEVTLSMTDplsqtSRWQ 1052
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDP-TPLNDGQWHRVAVERNG-----RSVT 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 41327708    1053 MEVDNETPfvTSTIATGSLNFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEIGG 1104
Cdd:smart00282   75 LSVDGGNR--VSGESPGGLTILNLDGPLYLGglpedlkLPPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
509-649 3.71e-14

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 70.83  E-value: 3.71e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708     509 NIALRFQTVQPMALLLF--RSNRDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVIfAEAVTLTLIDDS 586
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVE-RNGRSVTLSVDG 79

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41327708     587 CKEKcIAKAP---TPLESDQSIcafqnsFLGGLPVGMTSNGVallnfynmPSTPSFVGCLQDIKID 649
Cdd:smart00282   80 GNRV-SGESPgglTILNLDGPL------YLGGLPEDLKLPPL--------PVTPGFRGCIRNLKVN 130
Laminin_G_1 pfam00054
Laminin G domain;
980-1104 7.83e-13

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 66.96  E-value: 7.83e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708    980 FRTRDANVIILHAEK--EPEFLNISIQDSRLFFQLQSGNSfyMLSLTSLQSVNDGTWHEVTLSMTdplsqTSRWQMEVDN 1057
Cdd:pfam00054    1 FRTTEPSGLLLYNGTqtERDFLALELRDGRLEVSYDLGSG--AAVVRSGDKLNDGKWHSVELERN-----GRSGTLSVDG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 41327708   1058 ETPFVTSTiATGSLNFLKDNTDIYVG--------DRAIDNIKGLQGCLSTIEIGG 1104
Cdd:pfam00054   74 EARPTGES-PLGATTDLDVDGPLYVGglpslgvkKRRLAISPSFDGCIRDVIVNG 127
LamG smart00282
Laminin G domain;
738-860 1.12e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 66.59  E-value: 1.12e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708     738 SLSMFVRTLQPSGLLLALENSTY-QYIRVWLERGRL-AMLTPNSPKLVVK---FVLNDGNVHLISLKIKPYKIELY--QS 810
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLvLRYDLGSGPARLTsdpTPLNDGQWHRVAVERNGRSVTLSvdGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 41327708     811 SQNLGFISASTWKIEKGDVIYIGGLPD--KQETELNGGFFKGCIQDVRLNNQ 860
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEdlKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
514-649 4.46e-08

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 53.09  E-value: 4.46e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708    514 FQTVQPMALLLF--RSNRDVFVKLELLSGYIHLSIQVNNQsKVLLFISHNTSDGEWHFVEVifaEAVT--LTLIDDSCKE 589
Cdd:pfam00054    1 FRTTEPSGLLLYngTQTERDFLALELRDGRLEVSYDLGSG-AAVVRSGDKLNDGKWHSVEL---ERNGrsGTLSVDGEAR 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708    590 KCIAkapTPLESDQSICAFQNSFLGGLPvgmtSNGVALLNFynmPSTPSFVGCLQDIKID 649
Cdd:pfam00054   77 PTGE---SPLGATTDLDVDGPLYVGGLP----SLGVKKRRL---AISPSFDGCIRDVIVN 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 148-183 1.02e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.02e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 41327708  148 DHDECAS-SPCQNGAVCQDGIDGYSCFCVPGYQGRHC 183
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
397-438 3.59e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.63  E-value: 3.59e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 41327708     397 DVNECSS-NPCQNGGTCENLPGNYTCHCPfdnlsRTFYGGRDC 438
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 187-222 6.18e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 6.18e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 41327708  187 VDECAS-DPCKNEATCLNEIGRYTCICPHNYSGVNCE 222
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 397-424 2.41e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 2.41e-06
                         10        20
                 ....*....|....*....|....*....
gi 41327708  397 DVNECSS-NPCQNGGTCENLPGNYTCHCP 424
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCP 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
148-184 2.70e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.70e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 41327708     148 DHDECAS-SPCQNGAVCQDGIDGYSCFCVPGYQ-GRHCD 184
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 225-260 6.96e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 6.96e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 41327708  225 IDEC-WSQPCLNGATCQDALGAYFCDCAPGFLGDHCE 260
Cdd:cd00054    2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 72-108 7.76e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 7.76e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 41327708   72 DPCFS-NPCQGSATCVNTPGerSFLCKCPPGYSGTICE 108
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVG--SYRCSCPPGYTGRNCE 38
Laminin_G_1 pfam00054
Laminin G domain;
743-863 8.33e-06

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 46.54  E-value: 8.33e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327708    743 VRTLQPSGLLLALENSTY-QYIRVWLERGRLAMLTPNSPKLVV---KFVLNDGNVHLISLKIKPYKIELY---------- 808
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTErDFLALELRDGRLEVSYDLGSGAAVvrsGDKLNDGKWHSVELERNGRSGTLSvdgearptge 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 41327708    809 QSSQNLGFISASTwkiekgdVIYIGGLPDKQETEL---NGGFFKGCIQDVRLNNQNLE 863
Cdd:pfam00054   81 SPLGATTDLDVDG-------PLYVGGLPSLGVKKRrlaISPSFDGCIRDVIVNGKPLD 131
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1146-1175 9.63e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 9.63e-06
                         10        20        30
                 ....*....|....*....|....*....|
gi 41327708 1146 NPCLHGGNCEDIYSSYHCSCPLGWSGKHCE 1175
Cdd:cd00054    9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1297-1333 1.75e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.75e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 41327708 1297 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAFAGERCE 1333
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
186-222 2.66e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.66e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 41327708     186 EVDECAS-DPCKNEATCLNEIGRYTCICPHNYS-GVNCE 222
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1143-1173 3.72e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.72e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 41327708   1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKH 1173
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 262-299 4.72e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.72e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 41327708  262 NTDECASQ-PCLHGGLCVDGENRYSCNCTgSGFTGTHCE 299
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1177-1212 6.16e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 6.16e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 41327708 1177 NIDECFS-NPC-IHGNCSDRVAAYHCTCEPGYTGVNCE 1212
Cdd:cd00054    1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 309-337 1.83e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.83e-04
                         10        20
                 ....*....|....*....|....*....
gi 41327708  309 PCHNNATCEDSVDNYTCHCWPGYTGAQCE 337
Cdd:cd00054   10 PCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
224-260 1.86e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 1.86e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 41327708     224 EIDECWS-QPCLNGATCQDALGAYFCDCAPGF-LGDHCE 260
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 401-424 2.70e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 2.70e-04
                           10        20
                   ....*....|....*....|....
gi 41327708    401 CSSNPCQNGGTCENLPGNYTCHCP 424
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP 24
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 152-182 3.32e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 3.32e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 41327708    152 CASSPCQNGAVCQDGIDGYSCFCVPGYQGRH 182
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 190-220 3.35e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 3.35e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 41327708    190 CASDPCKNEATCLNEIGRYTCICPHNYSGVN 220
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1297-1333 3.67e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 3.67e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 41327708    1297 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAF-AGERCE 1333
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
77-108 5.18e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 5.18e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 41327708      77 NPCQGSATCVNTPGerSFLCKCPPGYS-GTICE 108
Cdd:smart00179    9 NPCQNGGTCVNTVG--SYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1146-1175 5.49e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 5.49e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 41327708    1146 NPCLHGGNCEDIYSSYHCSCPLGWS-GKHCE 1175
Cdd:smart00179    9 NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1214-1249 7.48e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 7.48e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 41327708 1214 DIDNCQS-HQCANGATCISHTNGYSCLCFGNFTGKFC 1249
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 151-183 8.65e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.23  E-value: 8.65e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 41327708  151 ECA-SSPCQNGAVCQDGIDGYSCFCVPGYQG-RHC 183
Cdd:cd00053    1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGdRSC 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 676-707 1.13e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.13e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 41327708  676 CESQ-PCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Cdd:cd00054    5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
309-337 1.59e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.59e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 41327708     309 PCHNNATCEDSVDNYTCHCWPGYT-GAQCE 337
Cdd:smart00179   10 PCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 889-923 1.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.92e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 41327708  889 NSCKS-NPCHNGGVCHSRWDDFSCSCPALTSGKACE 923
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1177-1212 2.70e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.70e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 41327708    1177 NIDECFS-NPCIHG-NCSDRVAAYHCTCEPGYT-GVNCE 1212
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
262-299 2.76e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.76e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 41327708     262 NTDECAS-QPCLHGGLCVDGENRYSCNCtGSGFT-GTHCE 299
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCEC-PPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 74-104 3.15e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 3.15e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 41327708     74 CFSNPCQGSATCVNTPGerSFLCKCPPGYSG 104
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPG--GYTCICPEGYTG 29
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 400-424 3.90e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 3.90e-03
                         10        20
                 ....*....|....*....|....*.
gi 41327708  400 ECS-SNPCQNGGTCENLPGNYTCHCP 424
Cdd:cd00053    1 ECAaSNPCSNGGTCVNTPGSYRCVCP 26
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 230-260 4.47e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 4.47e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 41327708  230 SQPCLNGATCQDALGAYFCDCAPGFLGD-HCE 260
Cdd:cd00053    5 SNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1144-1175 4.75e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 4.75e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 41327708 1144 NSNPCLHGGNCEDIYSSYHCSCPLGWSG-KHCE 1175
Cdd:cd00053    4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 266-295 5.41e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 5.41e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 41327708    266 CASQPCLHGGLCVDGENRYSCNCTgSGFTG 295
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 676-706 6.40e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 6.40e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 41327708    676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPN 706
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 228-258 6.53e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 6.53e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 41327708    228 CWSQPCLNGATCQDALGAYFCDCAPGFLGDH 258
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 76-104 8.49e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.53  E-value: 8.49e-03
                         10        20
                 ....*....|....*....|....*....
gi 41327708   76 SNPCQGSATCVNTPGerSFLCKCPPGYSG 104
Cdd:cd00053    5 SNPCSNGGTCVNTPG--SYRCVCPPGYTG 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 891-920 9.77e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 9.77e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 41327708    891 CKSNPCHNGGVCHSRWDDFSCSCPALTSGK 920
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 339-395 9.97e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 9.97e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 41327708  339 DLNECNS-NPCQSNGECVELssekqygritglpssfsyheASGYVCICQPGFTGIHCE 395
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNT--------------------VGSYRCSCPPGYTGRNCE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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