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Conserved domains on  [gi|41393554|ref|NP_958815|]
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putative RNA-binding protein Luc7-like 1 isoform b [Homo sapiens]

Protein Classification

LUC7 domain-containing protein( domain architecture ID 12042729)

LUC7 domain-containing protein similar to Homo sapiens Luc7-like protein 3 that may play a role in RNA splicing

Gene Ontology:  GO:0003729|GO:0006376|GO:0005685

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LUC7 pfam03194
LUC7 N_terminus; This family contains the N terminal region of several LUC7 protein homologs ...
5-242 2.20e-98

LUC7 N_terminus; This family contains the N terminal region of several LUC7 protein homologs and only contains eukaryotic proteins. LUC7 has been shown to be a U1 snRNA associated protein with a role in splice site recognition. The family also contains human and mouse LUC7 like (LUC7L) proteins and human cisplatin resistance-associated overexpressed protein (CROP).


:

Pssm-ID: 460842 [Multi-domain]  Cd Length: 246  Bit Score: 292.20  E-value: 2.20e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393554     5 AQMRALLDQLMGTARDGDETRQR--VKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERD-LF 81
Cdd:pfam03194   1 DAQRALLDELMGRNRNLAPSEKKkkKHFDDPEVCKSYLVGFCPHDLFTNTKADLGPCPKIHDEALKADYEKASKRKKkYG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393554    82 FELDAMDHLESFIAECDRRTELAKKRLAETQEEISAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEK 161
Cdd:pfam03194  81 YEREFLRFLQKLIDDVDRKIRKGKQRLELTQEEIEQTDELKQEQISVLEEKIKKLLEEAEELGEEGNVDEAQKLMKKVEE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393554   162 VRAKKKEAEEEYRN-SMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRN 240
Cdd:pfam03194 161 LKEEKEELEQQYESlTKESAASQEKKMEVCEVCGAFLIVNDADRRLADHLTGKQHLGYAKIRDTLEELKEKIEERREERE 240

                  ..
gi 41393554   241 QD 242
Cdd:pfam03194 241 ER 242
 
Name Accession Description Interval E-value
LUC7 pfam03194
LUC7 N_terminus; This family contains the N terminal region of several LUC7 protein homologs ...
5-242 2.20e-98

LUC7 N_terminus; This family contains the N terminal region of several LUC7 protein homologs and only contains eukaryotic proteins. LUC7 has been shown to be a U1 snRNA associated protein with a role in splice site recognition. The family also contains human and mouse LUC7 like (LUC7L) proteins and human cisplatin resistance-associated overexpressed protein (CROP).


Pssm-ID: 460842 [Multi-domain]  Cd Length: 246  Bit Score: 292.20  E-value: 2.20e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393554     5 AQMRALLDQLMGTARDGDETRQR--VKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERD-LF 81
Cdd:pfam03194   1 DAQRALLDELMGRNRNLAPSEKKkkKHFDDPEVCKSYLVGFCPHDLFTNTKADLGPCPKIHDEALKADYEKASKRKKkYG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393554    82 FELDAMDHLESFIAECDRRTELAKKRLAETQEEISAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEK 161
Cdd:pfam03194  81 YEREFLRFLQKLIDDVDRKIRKGKQRLELTQEEIEQTDELKQEQISVLEEKIKKLLEEAEELGEEGNVDEAQKLMKKVEE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393554   162 VRAKKKEAEEEYRN-SMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRN 240
Cdd:pfam03194 161 LKEEKEELEQQYESlTKESAASQEKKMEVCEVCGAFLIVNDADRRLADHLTGKQHLGYAKIRDTLEELKEKIEERREERE 240

                  ..
gi 41393554   241 QD 242
Cdd:pfam03194 241 ER 242
LUC7 COG5200
U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and ...
5-230 1.89e-47

U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification];


Pssm-ID: 227527 [Multi-domain]  Cd Length: 258  Bit Score: 161.67  E-value: 1.89e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393554   5 AQMRALLDQLMGTARDGDETRQRVKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERDLFFEL 84
Cdd:COG5200   3 AEQRKVLEQLMGPERSTFDPCRPTHFTDKKVCISMLVGFCPFDLFRNTKRSLGKCPTSHEEKYKAEYERNGRERAEEYEW 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393554  85 DAMDHLESFIAECDRRTELAKKRLAETQEEiSAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRA 164
Cdd:COG5200  83 EYLRLLVRIVLSCNDGIRAAGLEDRTTPEE-FGKIKEKEELFNRVDESIGELGMEGDALAKRKLVERACSAFNELERLRE 161
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41393554 165 KKKEAEEEYRNSMP-ASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRK 230
Cdd:COG5200 162 ERKEIKEAVYSMVEnNGQGTHQKLQVCGICGAYLSRLDTDRRLADHFNGKLHLGYLLVRSDLADLLK 228
 
Name Accession Description Interval E-value
LUC7 pfam03194
LUC7 N_terminus; This family contains the N terminal region of several LUC7 protein homologs ...
5-242 2.20e-98

LUC7 N_terminus; This family contains the N terminal region of several LUC7 protein homologs and only contains eukaryotic proteins. LUC7 has been shown to be a U1 snRNA associated protein with a role in splice site recognition. The family also contains human and mouse LUC7 like (LUC7L) proteins and human cisplatin resistance-associated overexpressed protein (CROP).


Pssm-ID: 460842 [Multi-domain]  Cd Length: 246  Bit Score: 292.20  E-value: 2.20e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393554     5 AQMRALLDQLMGTARDGDETRQR--VKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERD-LF 81
Cdd:pfam03194   1 DAQRALLDELMGRNRNLAPSEKKkkKHFDDPEVCKSYLVGFCPHDLFTNTKADLGPCPKIHDEALKADYEKASKRKKkYG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393554    82 FELDAMDHLESFIAECDRRTELAKKRLAETQEEISAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEK 161
Cdd:pfam03194  81 YEREFLRFLQKLIDDVDRKIRKGKQRLELTQEEIEQTDELKQEQISVLEEKIKKLLEEAEELGEEGNVDEAQKLMKKVEE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393554   162 VRAKKKEAEEEYRN-SMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRN 240
Cdd:pfam03194 161 LKEEKEELEQQYESlTKESAASQEKKMEVCEVCGAFLIVNDADRRLADHLTGKQHLGYAKIRDTLEELKEKIEERREERE 240

                  ..
gi 41393554   241 QD 242
Cdd:pfam03194 241 ER 242
LUC7 COG5200
U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and ...
5-230 1.89e-47

U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification];


Pssm-ID: 227527 [Multi-domain]  Cd Length: 258  Bit Score: 161.67  E-value: 1.89e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393554   5 AQMRALLDQLMGTARDGDETRQRVKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERDLFFEL 84
Cdd:COG5200   3 AEQRKVLEQLMGPERSTFDPCRPTHFTDKKVCISMLVGFCPFDLFRNTKRSLGKCPTSHEEKYKAEYERNGRERAEEYEW 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393554  85 DAMDHLESFIAECDRRTELAKKRLAETQEEiSAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRA 164
Cdd:COG5200  83 EYLRLLVRIVLSCNDGIRAAGLEDRTTPEE-FGKIKEKEELFNRVDESIGELGMEGDALAKRKLVERACSAFNELERLRE 161
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41393554 165 KKKEAEEEYRNSMP-ASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRK 230
Cdd:COG5200 162 ERKEIKEAVYSMVEnNGQGTHQKLQVCGICGAYLSRLDTDRRLADHFNGKLHLGYLLVRSDLADLLK 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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