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Conserved domains on  [gi|157837979|ref|NP_963836|]
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mediator of RNA polymerase II transcription subunit 8 isoform 4 [Homo sapiens]

Protein Classification

Med8 domain-containing protein( domain architecture ID 10562974)

Med8 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Med8 pfam10232
Mediator of RNA polymerase II transcription complex subunit 8; Arc32, or Med8, is one of the ...
1-265 6.45e-119

Mediator of RNA polymerase II transcription complex subunit 8; Arc32, or Med8, is one of the subunits of the Mediator complex of RNA polymerase II. The region conserved contains two alpha helices putatively necessary for binding to other subunits within the core of the Mediator complex. The N-terminus of Med8 binds to the essential core Head part of Mediator and the C-terminus hinges to Med18 on the non-essential part of the Head that also includes Med20.


:

Pssm-ID: 463012  Cd Length: 230  Bit Score: 339.32  E-value: 6.45e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157837979    1 MQREEKQLEASLDALLSQVADLKNSLGSFICKLENEYGRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLV 80
Cdd:pfam10232   1 MQREEKQLEASLEAIRQRLNDLKNSLASLIFKLENEYPLPNWPSLLDNFALISGQLTTLSKVLKSEKTPLLRNLVVLPLP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157837979   81 LSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISK--EE 158
Cdd:pfam10232  81 LSPGRDEELARLTEGRVPVFSHDVVPDLLRTKLDPEVEPREAQLEARARNLGGEYTQKQIAGVNKVVTGLRRKLSKarEE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157837979  159 RESESGGLRPNKQTFNPTDTNALVAAVAFGKGLSNWRPSGSSGPGQAGQpgagtilagtsglqqvqmagapsqqqpmlsg 238
Cdd:pfam10232 161 WEEEEGSRGGIQQTSSGADTEALVAAVGFGKGLKPGVEFGISGPPPSGG------------------------------- 209
                         250       260
                  ....*....|....*....|....*..
gi 157837979  239 vqmaqaGQPGKMPSGIKTNIKSASMHP 265
Cdd:pfam10232 210 ------GMMGKLPSGIKTNIKGAQIHP 230
 
Name Accession Description Interval E-value
Med8 pfam10232
Mediator of RNA polymerase II transcription complex subunit 8; Arc32, or Med8, is one of the ...
1-265 6.45e-119

Mediator of RNA polymerase II transcription complex subunit 8; Arc32, or Med8, is one of the subunits of the Mediator complex of RNA polymerase II. The region conserved contains two alpha helices putatively necessary for binding to other subunits within the core of the Mediator complex. The N-terminus of Med8 binds to the essential core Head part of Mediator and the C-terminus hinges to Med18 on the non-essential part of the Head that also includes Med20.


Pssm-ID: 463012  Cd Length: 230  Bit Score: 339.32  E-value: 6.45e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157837979    1 MQREEKQLEASLDALLSQVADLKNSLGSFICKLENEYGRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLV 80
Cdd:pfam10232   1 MQREEKQLEASLEAIRQRLNDLKNSLASLIFKLENEYPLPNWPSLLDNFALISGQLTTLSKVLKSEKTPLLRNLVVLPLP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157837979   81 LSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISK--EE 158
Cdd:pfam10232  81 LSPGRDEELARLTEGRVPVFSHDVVPDLLRTKLDPEVEPREAQLEARARNLGGEYTQKQIAGVNKVVTGLRRKLSKarEE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157837979  159 RESESGGLRPNKQTFNPTDTNALVAAVAFGKGLSNWRPSGSSGPGQAGQpgagtilagtsglqqvqmagapsqqqpmlsg 238
Cdd:pfam10232 161 WEEEEGSRGGIQQTSSGADTEALVAAVGFGKGLKPGVEFGISGPPPSGG------------------------------- 209
                         250       260
                  ....*....|....*....|....*..
gi 157837979  239 vqmaqaGQPGKMPSGIKTNIKSASMHP 265
Cdd:pfam10232 210 ------GMMGKLPSGIKTNIKGAQIHP 230
 
Name Accession Description Interval E-value
Med8 pfam10232
Mediator of RNA polymerase II transcription complex subunit 8; Arc32, or Med8, is one of the ...
1-265 6.45e-119

Mediator of RNA polymerase II transcription complex subunit 8; Arc32, or Med8, is one of the subunits of the Mediator complex of RNA polymerase II. The region conserved contains two alpha helices putatively necessary for binding to other subunits within the core of the Mediator complex. The N-terminus of Med8 binds to the essential core Head part of Mediator and the C-terminus hinges to Med18 on the non-essential part of the Head that also includes Med20.


Pssm-ID: 463012  Cd Length: 230  Bit Score: 339.32  E-value: 6.45e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157837979    1 MQREEKQLEASLDALLSQVADLKNSLGSFICKLENEYGRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLV 80
Cdd:pfam10232   1 MQREEKQLEASLEAIRQRLNDLKNSLASLIFKLENEYPLPNWPSLLDNFALISGQLTTLSKVLKSEKTPLLRNLVVLPLP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157837979   81 LSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISK--EE 158
Cdd:pfam10232  81 LSPGRDEELARLTEGRVPVFSHDVVPDLLRTKLDPEVEPREAQLEARARNLGGEYTQKQIAGVNKVVTGLRRKLSKarEE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157837979  159 RESESGGLRPNKQTFNPTDTNALVAAVAFGKGLSNWRPSGSSGPGQAGQpgagtilagtsglqqvqmagapsqqqpmlsg 238
Cdd:pfam10232 161 WEEEEGSRGGIQQTSSGADTEALVAAVGFGKGLKPGVEFGISGPPPSGG------------------------------- 209
                         250       260
                  ....*....|....*....|....*..
gi 157837979  239 vqmaqaGQPGKMPSGIKTNIKSASMHP 265
Cdd:pfam10232 210 ------GMMGKLPSGIKTNIKGAQIHP 230
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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