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Conserved domains on  [gi|42766422|ref|NP_976249|]
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fin bud initiation factor homolog precursor [Homo sapiens]

Protein Classification

Fibin domain-containing protein( domain architecture ID 11239385)

Fibin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fibin pfam15819
Fin bud initiation factor homolog; Fibin is a family of eukaryotic proteins expressed in the ...
 16-210 3.04e-111

Fin bud initiation factor homolog; Fibin is a family of eukaryotic proteins expressed in the lateral plate mesoderm of presumptive pectoral fin bud regions. It acts as a signal molecule for the expression of Tbx5, a gene involved in the specification of fore-limb identity. Fibin is found to be expressed in cerebellum, skeletal muscle and many other embryonic as well as adult mouse tissues, suggesting roles in both embryogenesis and in adult life. Although Fibin is routed through the endoplasmic reticulum (ER) no significant evidence for secretion is found. Fibin is post-translationally modified and forms dimers when expressed heterologously and its expression is regulated by a number of cellular signalling pathways.


:

Pssm-ID: 406297  Cd Length: 189  Bit Score: 315.92  E-value: 3.04e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42766422    16 CQGYFDGPLYPEMSNGTLHHYFVPDGDYEENDDPEKCQLLFRVSDHRRCSQGEGSQVgsllslTLREEFTVLGRQVEDAG 95
Cdd:pfam15819   1 CGGYFGGPLPPEMSNGTLHHFFVPDGDYEENDDPEKCQLLFKVSDRRPCGAEEDSDA------VLRDDFIILKRQVEDAA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42766422    96 RVLEGISKSISYDLDGEESYGKYLRRESHQIGDAYSNSDKSLTELESKFKQGQEQDSRQESRLNEDFLGMLVHTRSLLKE 175
Cdd:pfam15819  75 RVLEGIGKSISYDLDGEESYGKYLRRESQQIGEAFSVSDKSLEELEKKFKQSQEEEREEEQRLGDDFLQMVDHRRALLEE 154

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 42766422   176 TLDISVGLRDKYELLALTIRSHGTRLGRLKNDYLK 210
Cdd:pfam15819 155 TLDISGGLRDKHELLSLIVRSHGTRLSRLKNEYLK 189
 
Name Accession Description Interval E-value
Fibin pfam15819
Fin bud initiation factor homolog; Fibin is a family of eukaryotic proteins expressed in the ...
 16-210 3.04e-111

Fin bud initiation factor homolog; Fibin is a family of eukaryotic proteins expressed in the lateral plate mesoderm of presumptive pectoral fin bud regions. It acts as a signal molecule for the expression of Tbx5, a gene involved in the specification of fore-limb identity. Fibin is found to be expressed in cerebellum, skeletal muscle and many other embryonic as well as adult mouse tissues, suggesting roles in both embryogenesis and in adult life. Although Fibin is routed through the endoplasmic reticulum (ER) no significant evidence for secretion is found. Fibin is post-translationally modified and forms dimers when expressed heterologously and its expression is regulated by a number of cellular signalling pathways.


Pssm-ID: 406297  Cd Length: 189  Bit Score: 315.92  E-value: 3.04e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42766422    16 CQGYFDGPLYPEMSNGTLHHYFVPDGDYEENDDPEKCQLLFRVSDHRRCSQGEGSQVgsllslTLREEFTVLGRQVEDAG 95
Cdd:pfam15819   1 CGGYFGGPLPPEMSNGTLHHFFVPDGDYEENDDPEKCQLLFKVSDRRPCGAEEDSDA------VLRDDFIILKRQVEDAA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42766422    96 RVLEGISKSISYDLDGEESYGKYLRRESHQIGDAYSNSDKSLTELESKFKQGQEQDSRQESRLNEDFLGMLVHTRSLLKE 175
Cdd:pfam15819  75 RVLEGIGKSISYDLDGEESYGKYLRRESQQIGEAFSVSDKSLEELEKKFKQSQEEEREEEQRLGDDFLQMVDHRRALLEE 154

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 42766422   176 TLDISVGLRDKYELLALTIRSHGTRLGRLKNDYLK 210
Cdd:pfam15819 155 TLDISGGLRDKHELLSLIVRSHGTRLSRLKNEYLK 189
 
Name Accession Description Interval E-value
Fibin pfam15819
Fin bud initiation factor homolog; Fibin is a family of eukaryotic proteins expressed in the ...
 16-210 3.04e-111

Fin bud initiation factor homolog; Fibin is a family of eukaryotic proteins expressed in the lateral plate mesoderm of presumptive pectoral fin bud regions. It acts as a signal molecule for the expression of Tbx5, a gene involved in the specification of fore-limb identity. Fibin is found to be expressed in cerebellum, skeletal muscle and many other embryonic as well as adult mouse tissues, suggesting roles in both embryogenesis and in adult life. Although Fibin is routed through the endoplasmic reticulum (ER) no significant evidence for secretion is found. Fibin is post-translationally modified and forms dimers when expressed heterologously and its expression is regulated by a number of cellular signalling pathways.


Pssm-ID: 406297  Cd Length: 189  Bit Score: 315.92  E-value: 3.04e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42766422    16 CQGYFDGPLYPEMSNGTLHHYFVPDGDYEENDDPEKCQLLFRVSDHRRCSQGEGSQVgsllslTLREEFTVLGRQVEDAG 95
Cdd:pfam15819   1 CGGYFGGPLPPEMSNGTLHHFFVPDGDYEENDDPEKCQLLFKVSDRRPCGAEEDSDA------VLRDDFIILKRQVEDAA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42766422    96 RVLEGISKSISYDLDGEESYGKYLRRESHQIGDAYSNSDKSLTELESKFKQGQEQDSRQESRLNEDFLGMLVHTRSLLKE 175
Cdd:pfam15819  75 RVLEGIGKSISYDLDGEESYGKYLRRESQQIGEAFSVSDKSLEELEKKFKQSQEEEREEEQRLGDDFLQMVDHRRALLEE 154

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 42766422   176 TLDISVGLRDKYELLALTIRSHGTRLGRLKNDYLK 210
Cdd:pfam15819 155 TLDISGGLRDKHELLSLIVRSHGTRLSRLKNEYLK 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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