NCBI Conserved Domain Search

Conserved domains on [gi|255069790|ref|NP_997058|]

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olfactory receptor 239 [Mus musculus]

Protein Classification

olfactory receptor( domain architecture ID 11607024)

olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 10, subfamily A olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

41-302

2.59e-131

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 374.48 E-value: 2.59e-131

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15225   17 GNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTECFLLAAMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGE-NVLEVAkg 199
Cdd:cd15225   97 DRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACADtSLNEIA-- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 200 VGIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITY 279
Cdd:cd15225  175 IFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYSPETDKLLSLFY 254

                        250       260
                 ....*....|....*....|...
gi 255069790 280 TVLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15225  255 TVVTPMLNPIIYSLRNKEVKGAL 277

Name

Accession

Description

Interval

E-value

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

41-302

2.59e-131

Pssm-ID: 320353 Cd Length: 277 Bit Score: 374.48 E-value: 2.59e-131

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15225   17 GNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTECFLLAAMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGE-NVLEVAkg 199
Cdd:cd15225   97 DRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACADtSLNEIA-- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 200 VGIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITY 279
Cdd:cd15225  175 IFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYSPETDKLLSLFY 254

                        250       260
                 ....*....|....*....|...
gi 255069790 280 TVLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15225  255 TVVTPMLNPIIYSLRNKEVKGAL 277

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

41-307

4.74e-37

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 133.40 E-value: 4.74e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790   41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:pfam13853  11 GNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAMAV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGEnvLEVAKGV 200
Cdd:pfam13853  91 DRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCAD--IKVNNIY 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  201 GIVCITALLGC-FLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHY----GFASVIYLKPKGPKSLEgdTLM 275
Cdd:pfam13853 169 GLFVVTSTFGIdSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYtpmiGLSMVHRFGHNVPPLLQ--IMM 246

                         250       260       270
                  ....*....|....*....|....*....|..
gi 255069790  276 GITYTVLTPFLSPIIFSLRNKELKNAMKKIFL 307
Cdd:pfam13853 247 ANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278

Name

Accession

Description

Interval

E-value

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

41-302

2.59e-131

Pssm-ID: 320353 Cd Length: 277 Bit Score: 374.48 E-value: 2.59e-131

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15225   17 GNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTECFLLAAMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGE-NVLEVAkg 199
Cdd:cd15225   97 DRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACADtSLNEIA-- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 200 VGIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITY 279
Cdd:cd15225  175 IFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYSPETDKLLSLFY 254

                        250       260
                 ....*....|....*....|...
gi 255069790 280 TVLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15225  255 TVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

41-295

2.42e-105

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 308.26 E-value: 2.42e-105

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd13954   17 GNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGGTECFLLAVMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGEN-VLEVAkg 199
Cdd:cd13954   97 DRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLSCSDTsLNELV-- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 200 VGIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITY 279
Cdd:cd13954  175 IFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSSYSSDLDKVVSVFY 254

                        250
                 ....*....|....*.
gi 255069790 280 TVLTPFLSPIIFSLRN 295
Cdd:cd13954  255 TVVTPMLNPIIYSLRN 270

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

41-295

2.52e-96

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 285.53 E-value: 2.52e-96

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15912   17 GNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTTEFFLLAVMSF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGE-NVLEVAkg 199
Cdd:cd15912   97 DRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKLSCSDtRLIELL-- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 200 VGIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITY 279
Cdd:cd15912  175 DFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQSSSLDLNKVVALLN 254

                        250
                 ....*....|....*.
gi 255069790 280 TVLTPFLSPIIFSLRN 295
Cdd:cd15912  255 TVVTPLLNPFIYTLRN 270

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

41-295

7.71e-96

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 284.40 E-value: 7.71e-96

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15230   17 GNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFLLAAMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGE---NVLEVA 197
Cdd:cd15230   97 DRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSDthiNELVLF 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 198 KGVGIVCITAllgcFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGI 277
Cdd:cd15230  177 AFSGFIGLST----LLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYSLDQDKVVSV 252

                        250
                 ....*....|....*...
gi 255069790 278 TYTVLTPFLSPIIFSLRN 295
Cdd:cd15230  253 FYTVVIPMLNPLIYSLRN 270

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

41-295

4.34e-92

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 274.75 E-value: 4.34e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15911   17 GNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATECYLLAVMSY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGE-NVLEVAkg 199
Cdd:cd15911   97 DRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDtSLVELV-- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 200 VGIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITY 279
Cdd:cd15911  175 TFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTSRDLNKVFSLFY 254

                        250
                 ....*....|....*.
gi 255069790 280 TVLTPFLSPIIFSLRN 295
Cdd:cd15911  255 TVLTPLVNPLIYSLRN 270

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

41-302

1.83e-90

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 271.06 E-value: 1.83e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15231   17 GNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLLLAVMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGE----NVLEV 196
Cdd:cd15231   97 DRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLKLSCSDtslnEVLLL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 197 AKGVGI-----VCITAllgcfllillSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEG 271
Cdd:cd15231  177 VASVFIgltpfLFIVI----------SYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGYSLDK 246

                        250       260       270
                 ....*....|....*....|....*....|.
gi 255069790 272 DTLMGITYTVLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15231  247 DTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

41-302

2.21e-90

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 270.58 E-value: 2.21e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15421   17 GNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAECLLLALMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACgENVLEVAKGV 200
Cdd:cd15421   97 DRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLSC-ADTSAYETVV 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 GIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITYT 280
Cdd:cd15421  176 YVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYHSPEQDKVVSVFYT 255

                        250       260
                 ....*....|....*....|..
gi 255069790 281 VLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15421  256 ILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

41-302

9.13e-90

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 269.09 E-value: 9.13e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15235   18 GNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFLLAVMAY 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGE----NVLEV 196
Cdd:cd15235   98 DRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDtslnELLIF 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 197 AKGVGIV-----CITAllgcfllillSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEG 271
Cdd:cd15235  178 TEGAVVVlgpflLIVL----------SYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSSYSADK 247

                        250       260       270
                 ....*....|....*....|....*....|.
gi 255069790 272 DTLMGITYTVLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15235  248 DRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

41-304

2.10e-89

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 268.36 E-value: 2.10e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15417   17 WNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTECFLLAAMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGEN------VL 194
Cdd:cd15417   97 DRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCSDTfisqvvLF 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 195 EVAKGVGIVCItallgcfLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTL 274
Cdd:cd15417  177 LVAVLFGVFSV-------LVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSHSQDQDKV 249

                        250       260       270
                 ....*....|....*....|....*....|
gi 255069790 275 MGITYTVLTPFLSPIIFSLRNKELKNAMKK 304
Cdd:cd15417  250 ASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

41-295

3.21e-89

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 267.60 E-value: 3.21e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15237   17 GNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTECVLLAVMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLEVAKgV 200
Cdd:cd15237   97 DRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLACADTSLNEAV-I 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 GIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITYT 280
Cdd:cd15237  176 FVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTHSPDQDKMISVFYT 255

                        250
                 ....*....|....*
gi 255069790 281 VLTPFLSPIIFSLRN 295
Cdd:cd15237  256 IVTPMLNPLIYSLRN 270

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

11-306

2.54e-88

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 266.15 E-value: 2.54e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  11 EFILIGFSTFPHLQLMFFLLFLLMYLFTLLGNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLH 90
Cdd:cd15943    1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  91 SIAFLACASQMFFSFTFGFTHSFLLTVMGYDRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCG 170
Cdd:cd15943   81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 171 PNEIHHFACHVPPLLKLACGEN-VLEVAkgVGIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVV 249
Cdd:cd15943  161 SNVINHFFCDVPPLLKLSCSDThVNEIV--LFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAV 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 255069790 250 VVHYGFASVIYLKPKGPKSLEGDTLMGITYTVLTPFLSPIIFSLRNKELKNAMKKIF 306
Cdd:cd15943  239 TIFYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

41-295

9.20e-88

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 263.54 E-value: 9.20e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15227   17 GNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELALLTVMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLAC-GENVLEVAKG 199
Cdd:cd15227   97 DRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKLSCsDTYLNEIGVL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 200 VGIVCITalLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITY 279
Cdd:cd15227  177 VLSVCLG--LGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSPSLLDLLLSVFY 254

                        250
                 ....*....|....*.
gi 255069790 280 TVLTPFLSPIIFSLRN 295
Cdd:cd15227  255 SVVPPTLNPIIYSLRN 270

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

12-299

4.20e-87

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 262.64 E-value: 4.20e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  12 FILIGFSTFPHLQLMFFLLFLLMYLFTLLGNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHS 91
Cdd:cd15408    1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  92 IAFLACASQMFFSFTFGFTHSFLLTVMGYDRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGP 171
Cdd:cd15408   81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 172 NEIHHFACHVPPLLKLACGE---NVLEVAKGVGIVCITallgCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTV 248
Cdd:cd15408  161 NVINHFFCDGPPLLALSCSDtslNEMLLFAFVGFNVLT----TTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTA 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 255069790 249 VVVHYGFASVIYLKPKGPKSLEGDTLMGITYTVLTPFLSPIIFSLRNKELK 299
Cdd:cd15408  237 VTLFYGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

41-302

7.02e-87

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 261.76 E-value: 7.02e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15229   17 GNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFLLSAMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLEVAKGV 200
Cdd:cd15229   97 DRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDTFANKMVLL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 GIVCITAlLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITYT 280
Cdd:cd15229  177 TSSVIFG-LGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASSSVLDRVFSIQYS 255

                        250       260
                 ....*....|....*....|..
gi 255069790 281 VLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15229  256 ILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

41-304

1.94e-85

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 258.07 E-value: 1.94e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15416   17 GNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVECFLLAAMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGE----NVLEV 196
Cdd:cd15416   97 DRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLSCSDirlaKILPS 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 197 AKGVGIVCITallgcFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMG 276
Cdd:cd15416  177 ISSGIIILVT-----VLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYSMDQNKVVS 251

                        250       260
                 ....*....|....*....|....*...
gi 255069790 277 ITYTVLTPFLSPIIFSLRNKELKNAMKK 304
Cdd:cd15416  252 VFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

41-304

2.06e-85

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 258.01 E-value: 2.06e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15419   17 GNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEGFLLAAMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLAC-----GENVLE 195
Cdd:cd15419   97 DRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSCsdtfiNELVMF 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 196 VAKGVGIVCitallgCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLM 275
Cdd:cd15419  177 VLCGLIIVS------TILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVSSPEQSKVV 250

                        250       260
                 ....*....|....*....|....*....
gi 255069790 276 GITYTVLTPFLSPIIFSLRNKELKNAMKK 304
Cdd:cd15419  251 SVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

41-295

1.62e-84

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 255.62 E-value: 1.62e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15918   17 GNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDNFLLAVMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGEN------VL 194
Cdd:cd15918   97 DRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDThlnelvIL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 195 EVAKGVGIVCITallgcflLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTL 274
Cdd:cd15918  177 VLGGLVGLVPFL-------CILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHSASKDSV 249

                        250       260
                 ....*....|....*....|.
gi 255069790 275 MGITYTVLTPFLSPIIFSLRN 295
Cdd:cd15918  250 AAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

41-302

3.21e-83

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 252.32 E-value: 3.21e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15429   17 GNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEFILLAVMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVL-EVAKG 199
Cdd:cd15429   97 DRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDTSLnEVAIL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 200 VGIVCItaLLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITY 279
Cdd:cd15429  177 VSSVVV--LLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSSALQEKMISLFY 254

                        250       260
                 ....*....|....*....|...
gi 255069790 280 TVLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15429  255 AVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

12-306

4.75e-83

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 252.58 E-value: 4.75e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  12 FILIGFSTFPHLQLMFFLLFLLMYLFTLLGNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHS 91
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  92 IAFLACASQMFFSFTFGFTHSFLLTVMGYDRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGP 171
Cdd:cd15410   81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 172 NEIHHFACHVPPLLKLACGENVL-EVAkgVGIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVV 250
Cdd:cd15410  161 NVINHFFCDLPPLLSLSCSDTYLnELL--LFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAIT 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 255069790 251 VHYGFASVIYLKPKGPKSLEGDTLMGITYTVLTPFLSPIIFSLRNKELKNAMKKIF 306
Cdd:cd15410  239 IFHGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

42-295

2.26e-82

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 249.89 E-value: 2.26e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  42 NLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGYD 121
Cdd:cd15224   18 NLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVLLAVMAYD 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 122 RYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGEnvLEVAKGVG 201
Cdd:cd15224   98 RYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCTD--MSLAELVD 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 202 -IVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITYT 280
Cdd:cd15224  176 fILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAISSFDSNKLVSVLYT 255

                        250
                 ....*....|....*
gi 255069790 281 VLTPFLSPIIFSLRN 295
Cdd:cd15224  256 VVTPLLNPIIYCLRN 270

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

41-295

1.69e-81

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 247.91 E-value: 1.69e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15431   17 GNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITECLLLAVMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVgGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLEVAKGV 200
Cdd:cd15431   97 DRFVAICNPLRYTLIMSWRVCIQLAAGSWV-SAFLLTVIPVLTMPLHFCGPNVINHFFCEVQALLKLACSDTSLNEILMF 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 GIVCITaLLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITYT 280
Cdd:cd15431  176 ATSIFT-LLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSSSDQDKIISVFYG 254

                        250
                 ....*....|....*
gi 255069790 281 VLTPFLSPIIFSLRN 295
Cdd:cd15431  255 VVTPMLNPLIYSLRN 269

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

41-302

3.31e-81

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 247.24 E-value: 3.31e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15420   17 GNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECVLLAVMSY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGEN-VLEVAKG 199
Cdd:cd15420   97 DRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLACADTwINEILIF 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 200 VGIVCItaLLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITY 279
Cdd:cd15420  177 AGCVFI--LLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNSAEQEKILSLFY 254

                        250       260
                 ....*....|....*....|...
gi 255069790 280 TVLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15420  255 SLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

12-304

2.63e-80

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 245.42 E-value: 2.63e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  12 FILIGFSTFPHLQLMFFLLFLLMYLFTLLGNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHS 91
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  92 IAFLACASQMFFSFTFGFTHSFLLTVMGYDRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGP 171
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 172 NEIHHFACHVPPLLKLACGE-NVLEVAkgVGIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVV 250
Cdd:cd15945  161 NTINHFFCDIPPLLALSCSDtQINELL--LFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVG 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 255069790 251 VHYGFASVIYLKPKGPKSLEGDTLMGITYTVLTPFLSPIIFSLRNKELKNAMKK 304
Cdd:cd15945  239 LFYGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

41-304

3.60e-80

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 244.62 E-value: 3.60e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15409   17 GNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECFLLAAMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGE---NVLEVA 197
Cdd:cd15409   97 DRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKISCTDpsiNELVLF 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 198 KGVGIVCItallGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGI 277
Cdd:cd15409  177 IFSGSIQV----FTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYALDQDMMDSL 252

                        250       260
                 ....*....|....*....|....*..
gi 255069790 278 TYTVLTPFLSPIIFSLRNKELKNAMKK 304
Cdd:cd15409  253 FYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

41-304

8.02e-80

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 243.76 E-value: 8.02e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15411   17 GNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECFLLGLMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACG-----ENVLE 195
Cdd:cd15411   97 DRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSdthvnEMLIF 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 196 VAKGVGIVcitallGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLM 275
Cdd:cd15411  177 ILAGLTLV------GSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYSLGQDKVA 250

                        250       260
                 ....*....|....*....|....*....
gi 255069790 276 GITYTVLTPFLSPIIFSLRNKELKNAMKK 304
Cdd:cd15411  251 SVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

41-302

1.21e-78

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 240.80 E-value: 1.21e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15228   17 GNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTECLLYTVMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLevAKGV 200
Cdd:cd15228   97 DRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLACADTSI--AETV 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 GIVCI-TALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLegDTLMGITY 279
Cdd:cd15228  175 SFTNVgLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSPVL--VTPVQIFN 252

                        250       260
                 ....*....|....*....|...
gi 255069790 280 TVLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15228  253 NVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

41-295

3.76e-78

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 239.19 E-value: 3.76e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GN-LLIMTTIWSEHsLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMG 119
Cdd:cd15430   17 GNgVLIIITILDSH-LHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECVLLAVMA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 120 YDRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLEVAKg 199
Cdd:cd15430   96 YDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDISLNEII- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 200 VGIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITY 279
Cdd:cd15430  175 MLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKNAQISDKLITLFY 254

                        250
                 ....*....|....*.
gi 255069790 280 TVLTPFLSPIIFSLRN 295
Cdd:cd15430  255 GVVTPMLNPIIYSLRN 270

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

41-304

1.12e-77

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 238.45 E-value: 1.12e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15412   17 GNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEYYMLAVMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACG-----ENVLE 195
Cdd:cd15412   97 DRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCSdtyvkETAMF 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 196 VAKGVGIVCitallgCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLM 275
Cdd:cd15412  177 IVAGFNLSS------SLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEESVEQSKIV 250

                        250       260
                 ....*....|....*....|....*....
gi 255069790 276 GITYTVLTPFLSPIIFSLRNKELKNAMKK 304
Cdd:cd15412  251 AVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

41-295

2.60e-77

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 237.16 E-value: 2.60e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15232   17 GNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELLLLTAMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLEVAKGV 200
Cdd:cd15232   97 DRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSDTSLNEIMAF 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 gIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITYT 280
Cdd:cd15232  177 -VADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSYSPEKDKVVAVLYS 255

                        250
                 ....*....|....*
gi 255069790 281 VLTPFLSPIIFSLRN 295
Cdd:cd15232  256 VVTPTLNPLIYSLRN 270

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

41-295

3.92e-77

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 236.50 E-value: 3.92e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15914   17 GNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGITECYLLTAMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLEVAKGV 200
Cdd:cd15914   97 DRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLACTDTSLNVLVDF 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 GIVCITaLLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITYT 280
Cdd:cd15914  177 VIHAVI-ILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSYSLDYDRAIAVVYA 255

                        250
                 ....*....|....*
gi 255069790 281 VLTPFLSPIIFSLRN 295
Cdd:cd15914  256 VLTPFFNPIIYSLRN 270

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

41-305

5.81e-77

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 236.88 E-value: 5.81e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15406   26 GNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAIAECYMLTAMAY 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACG-----ENVLE 195
Cdd:cd15406  106 DRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLLKLSCSstyinELLLF 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 196 VAKGVGIVCITallgcfLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLM 275
Cdd:cd15406  186 IVGGFNVLATT------LAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLKPSSSSSMTQEKVS 259

                        250       260       270
                 ....*....|....*....|....*....|
gi 255069790 276 GITYTVLTPFLSPIIFSLRNKELKNAMKKI 305
Cdd:cd15406  260 SVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

41-304

9.18e-77

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 236.06 E-value: 9.18e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15413   17 GNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELFLLSAMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLAC-GENVLEVAkg 199
Cdd:cd15413   97 DRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCsDTHEKELI-- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 200 VGIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITY 279
Cdd:cd15413  175 ILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSHSLDTDKMASVFY 254

                        250       260
                 ....*....|....*....|....*
gi 255069790 280 TVLTPFLSPIIFSLRNKELKNAMKK 304
Cdd:cd15413  255 TLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

41-304

1.80e-76

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 235.39 E-value: 1.80e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15415   17 GNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGFLLAVMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGEN----VLEV 196
Cdd:cd15415   97 DRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDThineLLLL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 197 AKGVGIVCITallgcFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMG 276
Cdd:cd15415  177 TFSGVIAMST-----LLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYSLEQEKVSA 251

                        250       260
                 ....*....|....*....|....*...
gi 255069790 277 ITYTVLTPFLSPIIFSLRNKELKNAMKK 304
Cdd:cd15415  252 VFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

41-302

4.80e-76

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 234.24 E-value: 4.80e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15424   17 GNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECLLLGAMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLEVAKGV 200
Cdd:cd15424   97 DRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACADTHITEAIVF 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 GI-VCItaLLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITY 279
Cdd:cd15424  177 GAgVLI--LLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGSTPDRDKQIAVFY 254

                        250       260
                 ....*....|....*....|...
gi 255069790 280 TVLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15424  255 IVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

41-304

1.55e-74

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 230.38 E-value: 1.55e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15407   17 GNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVENFLLASMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGE-NVLEVakg 199
Cdd:cd15407   97 DRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALSCSDiHISEI--- 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 200 vgIVCITA---LLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMG 276
Cdd:cd15407  174 --VLFFLAsfnVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSMDTDKMAS 251

                        250       260
                 ....*....|....*....|....*...
gi 255069790 277 ITYTVLTPFLSPIIFSLRNKELKNAMKK 304
Cdd:cd15407  252 VFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

41-295

7.27e-74

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 228.25 E-value: 7.27e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15939   17 GNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIFLLTVMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGE----NVLEV 196
Cdd:cd15939   97 DRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTDtyviGLLVV 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 197 AKGvGIVCItallGCFLLILLSYAFIVVTiLKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPkgPKSLEGDTLMG 276
Cdd:cd15939  177 ANS-GLICL----LSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRP--VTTFPIDKVVA 248

                        250
                 ....*....|....*....
gi 255069790 277 ITYTVLTPFLSPIIFSLRN 295
Cdd:cd15939  249 VFYTIITPMLNPLIYTLRN 267

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

41-302

1.67e-73

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 227.72 E-value: 1.67e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLST-LHSIAFLACASQMFFSFTFGFTHSFLLTVMG 119
Cdd:cd15916   17 GNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPgGKVISFGGCVAQLYFFHFLGSTECFLYTLMA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 120 YDRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGE---NVLEV 196
Cdd:cd15916   97 YDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACADttiNELVI 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 197 AKGVGIVCITAllgcFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGdtLMG 276
Cdd:cd15916  177 FASIGVVALGC----FILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSKEALDG--VIA 250

                        250       260
                 ....*....|....*....|....*.
gi 255069790 277 ITYTVLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15916  251 VFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

41-302

2.43e-73

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 227.07 E-value: 2.43e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15234   17 GNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDNFLLAVMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLevaKGV 200
Cdd:cd15234   97 DRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDTLI---NNI 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 GIVCITALLGCFLLI--LLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGIT 278
Cdd:cd15234  174 LIYLATVIFGGIPLSgiIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTHSSRKTAVASVM 253

                        250       260
                 ....*....|....*....|....
gi 255069790 279 YTVLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15234  254 YTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

41-302

8.40e-73

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 225.82 E-value: 8.40e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15428   17 GNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECALLSVMSY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVlEVAKGV 200
Cdd:cd15428   97 DRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDTH-QAEMAM 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 GIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITYT 280
Cdd:cd15428  176 FIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSSTSKEYDKMISVFYI 255

                        250       260
                 ....*....|....*....|..
gi 255069790 281 VLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15428  256 IVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

41-295

2.74e-72

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 224.49 E-value: 2.74e-72

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15915   17 GNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAMLLAVMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGG---SFMGTVVTTaifNLTFCGPNEIHHFACHVPPLLKLACGENVLEVa 197
Cdd:cd15915   97 DRYVAICNPLRYTVIMNPQVCLLLAVACWVTGffhALMHTVMTS---RLPFCGPNKINHFFCDIKPLLKLACGDTSLNL- 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 198 KGVGIVCITALLGCFLLILLSYAFIVVTILKIP-SAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMG 276
Cdd:cd15915  173 WLLNIVTGSIALGTFILTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGDSLEQDRIVA 252

                        250
                 ....*....|....*....
gi 255069790 277 ITYTVLTPFLSPIIFSLRN 295
Cdd:cd15915  253 LLYTVVTPVLNPLIYTLRN 271

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

41-295

3.16e-72

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 224.04 E-value: 3.16e-72

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15947   17 GNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGSTECVLLAVMAF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGE---NVLEVA 197
Cdd:cd15947   97 DRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIKLACVDttfNELELF 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 198 kgvgIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGI 277
Cdd:cd15947  177 ----VASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSYSQDQGKFISL 252

                        250
                 ....*....|....*...
gi 255069790 278 TYTVLTPFLSPIIFSLRN 295
Cdd:cd15947  253 FYTVVTPTLNPLIYTLRN 270

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

12-306

4.06e-72

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 224.66 E-value: 4.06e-72

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  12 FILIGFSTFPHLQLMFFLLFLLMYLFTLLGNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHS 91
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  92 IAFLACASQMFFSFTFGFTHSFLLTVMGYDRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGP 171
Cdd:cd15944   81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 172 NEIHHFACHVPPLLKLACGE-NVLEVAkgVGIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVV 250
Cdd:cd15944  161 NIINHFFCDVPPLLALSCSDtHINEIL--LYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVT 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 255069790 251 VHYGFASVIYLKPKGPKSLEGDTLMGITYTVLTPFLSPIIFSLRNKELKNAMKKIF 306
Cdd:cd15944  239 LFYGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

41-309

3.65e-71

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 221.92 E-value: 3.65e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15414   17 GNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAECFLLASMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLEVAKgV 200
Cdd:cd15414   97 DRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLSCADTQINKWV-L 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 GIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITYT 280
Cdd:cd15414  176 FIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSSLDLDKVVSVFYT 255

                        250       260
                 ....*....|....*....|....*....
gi 255069790 281 VLTPFLSPIIFSLRNKELKNAMKKIFLSK 309
Cdd:cd15414  256 AVIPMLNPLIYSLRNKEVKDALRRTIRRK 284

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

41-295

1.39e-70

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 219.88 E-value: 1.39e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15913   17 GNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTTECFFLSVMAF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGEnvlevAKGV 200
Cdd:cd15913   97 DRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLALSCVP-----APGT 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 GIVCIT----ALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMG 276
Cdd:cd15913  172 ELICYTlsslIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGNSTGMQKIVT 251

                        250
                 ....*....|....*....
gi 255069790 277 ITYTVLTPFLSPIIFSLRN 295
Cdd:cd15913  252 LFYSVVTPLLNPLIYSLRN 270

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

41-304

1.93e-70

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 220.04 E-value: 1.93e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15418   18 GNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSECFLLAAMAY 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACG-----ENVLE 195
Cdd:cd15418   98 DRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDdtrvyELILY 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 196 VAKGVGIVCITAllgcflLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLM 275
Cdd:cd15418  178 FILGFNVIAPTA------LILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSSHTPDRDKVV 251

                        250       260
                 ....*....|....*....|....*....
gi 255069790 276 GITYTVLTPFLSPIIFSLRNKELKNAMKK 304
Cdd:cd15418  252 ALFYTVVNPLLNPLIYSLRNKDVKEALKK 280

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

41-302

2.19e-69

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 216.92 E-value: 2.19e-69

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15942   17 GNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECFLYTVMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGE---NVLEVA 197
Cdd:cd15942   97 DRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADtafNELVTF 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 198 KGVGIVCITAllgcFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGdtLMGI 277
Cdd:cd15942  177 IDIGLVAMTC----FLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQDPLDG--VVAV 250

                        250       260
                 ....*....|....*....|....*
gi 255069790 278 TYTVLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15942  251 FYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

55-302

5.88e-69

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 216.09 E-value: 5.88e-69

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  55 LHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGYDRYVAICHPLRYNV 134
Cdd:cd15434   31 LHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGGTECVLLAVMAYDRYAAVCQPLHYTV 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 135 LMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLeVAKGVGIVCITALLGCFLL 214
Cdd:cd15434  111 VMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIKLACVDTTA-YEATIFALGVFILLFPLSL 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 215 ILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITYTVLTPFLSPIIFSLR 294
Cdd:cd15434  190 ILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSVSQDQGKFLTLFYTIVTPSLNPLIYTLR 269


                 ....*...
gi 255069790 295 NKELKNAM 302
Cdd:cd15434  270 NKDVKGAL 277

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

41-295

2.25e-68

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 213.99 E-value: 2.25e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15226   17 GNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMVLLIAMAF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGsFMGTVVTTA-IFNLTFCGPNEIHHFACHVPPLLKLACGEN-VLE--V 196
Cdd:cd15226   97 DRYVAICKPLHYLTIMSPRMCILLVVASWIIG-FIHSLSQLAfVVNLPFCGPNVVDSFFCDLPLVIKLACTDTyVLElmV 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 197 AKGVGIVCITAllgcFLLILLSYAFIVVTILKiPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLegDTLMG 276
Cdd:cd15226  176 VANSGLISLVC----FLLLLISYIVILVTVRK-HSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTFPV--DKFLA 248

                        250
                 ....*....|....*....
gi 255069790 277 ITYTVLTPFLSPIIFSLRN 295
Cdd:cd15226  249 VFYTVITPLLNPIIYTLRN 267

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

41-295

1.98e-67

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 211.95 E-value: 1.98e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15946   17 GNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECTLFSVMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLeVAKGV 200
Cdd:cd15946   97 DRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLACADTSL-NEMVD 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 GIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITYT 280
Cdd:cd15946  176 FVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNYSPERDKKISLFYN 255

                        250
                 ....*....|....*
gi 255069790 281 VLTPFLSPIIFSLRN 295
Cdd:cd15946  256 VFTALLNPVIYSLRN 270

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

41-295

2.45e-67

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 211.53 E-value: 2.45e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15940   17 GNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIFLLTIMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGE----NVLEV 196
Cdd:cd15940   97 DRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACTDtyliDILIV 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 197 AKG--VGIVCITAllgcfllILLSYAFIVVTILKIpSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPkgPKSLEGDTL 274
Cdd:cd15940  177 SNSglISLVCFVA-------LLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRP--STSFSEDKV 246

                        250       260
                 ....*....|....*....|.
gi 255069790 275 MGITYTVLTPFLSPIIFSLRN 295
Cdd:cd15940  247 VSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

41-295

1.43e-66

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 209.50 E-value: 1.43e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15936   17 GNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEVFLLSVMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGEN-VLEV--A 197
Cdd:cd15936   97 DRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACTDTfLLELlmV 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 198 KGVGIVCItallGCFLLILLSYAFIVVTIlKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKgpKSLEGDTLMGI 277
Cdd:cd15936  177 SNSGLVTL----LIFFILLISYTVILVKI-RTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPF--QTFPMDKAVSV 249

                        250
                 ....*....|....*...
gi 255069790 278 TYTVLTPFLSPIIFSLRN 295
Cdd:cd15936  250 LYTVITPMLNPMIYTLRN 267

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

41-302

7.23e-66

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 208.10 E-value: 7.23e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15432   17 GNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTECVLLAVMAF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLEVAkGV 200
Cdd:cd15432   97 DRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCVDTTANEA-EL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 GIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITYT 280
Cdd:cd15432  176 FVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNSSHDRGKMVALFYG 255

                        250       260
                 ....*....|....*....|..
gi 255069790 281 VLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15432  256 IITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

41-302

2.13e-65

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 206.93 E-value: 2.13e-65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15236   17 GNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSFLLAVMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLEvAKGV 200
Cdd:cd15236   97 DRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTSLN-ELVI 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 GIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITYT 280
Cdd:cd15236  176 FTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSDKDIVASVMYT 255

                        250       260
                 ....*....|....*....|..
gi 255069790 281 VLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15236  256 VVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

41-302

3.49e-63

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 201.11 E-value: 3.49e-63

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15405   17 GNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECYVLTAMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGE---NVLEVA 197
Cdd:cd15405   97 DRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCTStyvNELVVF 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 198 KGVGIVCITAllgcFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGI 277
Cdd:cd15405  177 VVVGINIIVP----SVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGSVNQGKVSSV 252

                        250       260
                 ....*....|....*....|....*
gi 255069790 278 TYTVLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15405  253 FYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

41-302

3.06e-62

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 198.92 E-value: 3.06e-62

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHT-PMYLFLCALSISEIFYTFAIIPRMLADLLS-TLHSIAFLACASQMFFSFTFGFTHSFLLTVM 118
Cdd:cd15941   17 GNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTlSGRTISFEGCVVQLYAFHFLASTECFLYTVM 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 119 GYDRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLEVAK 198
Cdd:cd15941   97 AYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLACADTTINELV 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 199 GVGIVCITAlLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSleGDTLMGIT 278
Cdd:cd15941  177 ILANIGIVA-AGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSSSQA--GAGAPAVF 253

                        250       260
                 ....*....|....*....|....
gi 255069790 279 YTVLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15941  254 YTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

41-302

2.02e-60

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 194.24 E-value: 2.02e-60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15233   17 GNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCFLLTAMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLEvAKGV 200
Cdd:cd15233   97 DRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCSSTHLN-ELLL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 GIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLMGITYT 280
Cdd:cd15233  176 FVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVYSSDKDKVIGILNT 255

                        250       260
                 ....*....|....*....|..
gi 255069790 281 VLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15233  256 VLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

41-295

5.79e-59

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 190.08 E-value: 5.79e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15938   17 GNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFLLTVMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENV---LEVA 197
Cdd:cd15938   97 DRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACTDTCvteLLMV 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 198 KGVGIVCITAllgcFLLILLSYAFIVVtilKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKgpKSLEGDTLMGI 277
Cdd:cd15938  177 SNSGLISTVC----FVVLVTSYTTILV---TIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPF--STFPVDKHVSV 247

                        250
                 ....*....|....*...
gi 255069790 278 TYTVLTPFLSPIIFSLRN 295
Cdd:cd15938  248 LYNVITPMLNPLIYTLRN 265

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

41-302

1.07e-56

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 184.42 E-value: 1.07e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15223   17 ANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAMESSILLVMAL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWV-GGSFMGTVVTTAIfNLTFCGPNEIHHFACHVPPLLKLACGENVLEVAKG 199
Cdd:cd15223   97 DRYVAICKPLRYPSIITKSFILKLVLFALIrSGLLVLPIVVLAS-QLSYCSSNVIEHCYCDHMALVSLACGDTTINSIYG 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 200 VgIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGD--TLMGI 277
Cdd:cd15223  176 L-AVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFGKTIPPDvhVLLSV 254

                        250       260
                 ....*....|....*....|....*
gi 255069790 278 TYTVLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15223  255 LYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

41-302

6.06e-56

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 182.68 E-value: 6.06e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15433   17 GNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECVLLAVMAF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACG-----ENVLE 195
Cdd:cd15433   97 DRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACGddettEVQMF 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 196 VAKGVGIVCITAllgcflLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDTLM 275
Cdd:cd15433  177 VARVVILLLPAA------LILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRYSQAHGKFV 250

                        250       260
                 ....*....|....*....|....*..
gi 255069790 276 GITYTVLTPFLSPIIFSLRNKELKNAM 302
Cdd:cd15433  251 SLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

41-295

2.20e-55

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 180.73 E-value: 2.20e-55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSE-HSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMG 119
Cdd:cd15935   17 GNLLIVVTVHADpHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEMLLLTLMA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 120 YDRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGE----NVLE 195
Cdd:cd15935   97 YDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKLACMDtyvvEVLM 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 196 VAKG--VGIVCITAllgcfllILLSYAFIVVTiLKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLegDT 273
Cdd:cd15935  177 VANSglLSLVCFLV-------LLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSSSSV--DK 246

                        250       260
                 ....*....|....*....|..
gi 255069790 274 LMGITYTVLTPFLSPIIFSLRN 295
Cdd:cd15935  247 VASVFYTLITPALNPLIYTLRN 268

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

41-295

7.89e-49

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 163.75 E-value: 7.89e-49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15937   17 GNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAAEMFLLVAMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLE----- 195
Cdd:cd15937   97 DRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKLACTNTYTVellmf 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 196 VAKGVGIVcitallGCFLLILLSYAFIVVTiLKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKgpKSLEGDTLM 275
Cdd:cd15937  177 SNSGLVIL------LCFLLLLISYAFLLAK-LRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPF--RSFPMDKVV 247

                        250       260
                 ....*....|....*....|
gi 255069790 276 GITYTVLTPFLSPIIFSLRN 295
Cdd:cd15937  248 AVFHTVIFPLLNPMIYTLRN 267

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

41-297

3.55e-47

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 159.97 E-value: 3.55e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15222   17 GNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMESSVLLAMAF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYN-VLMSPRgcaclVTWSWVGGSFMGTVVTTA----IFNLTFCGPNEIHHFACHVPPLLKLACGENVLE 195
Cdd:cd15222   97 DRFVAICNPLRYAsILTNSR-----IAKIGLAIVLRSVLLLLPlpflLKRLPFCHSNVLSHSYCLHQDVMKLACSDTRVN 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 196 VAKGVGIVcITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYG---FASVIYLKPKGPKSLEGd 272
Cdd:cd15222  172 SIYGLFVV-LSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVpmiGLSMVHRFGKHASPLVH- 249

                        250       260
                 ....*....|....*....|....*
gi 255069790 273 TLMGITYTVLTPFLSPIIFSLRNKE 297
Cdd:cd15222  250 VLMANVYLLVPPVLNPIIYSVKTKQ 274

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

41-298

1.45e-46

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 158.35 E-value: 1.45e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15950   17 GNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVESGVLLAMAF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLEVAKGV 200
Cdd:cd15950   97 DRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACADPRPSSLYSI 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 gIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHY--GFASVIYLKPKGPKSLEGDTLMGIT 278
Cdd:cd15950  177 -TGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYipGLLSIYTQRFGQGVPPHTQVLLADL 255

                        250       260
                 ....*....|....*....|
gi 255069790 279 YTVLTPFLSPIIFSLRNKEL 298
Cdd:cd15950  256 YLLVPPMLNPIIYGMRTKQI 275

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

41-298

5.62e-46

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 156.68 E-value: 5.62e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15917   17 GNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAMESGVLLAMAF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLEVAKGV 200
Cdd:cd15917   97 DRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACGDTRVNSIYGL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 gIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHY--GFASVIYLKPKGPKSLEGDTLMGIT 278
Cdd:cd15917  177 -FVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYtpALFSFLTHRFGHHVPPHVHILLANL 255

                        250       260
                 ....*....|....*....|
gi 255069790 279 YTVLTPFLSPIIFSLRNKEL 298
Cdd:cd15917  256 YLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

41-298

3.08e-43

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 149.45 E-value: 3.08e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15952   17 GNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGMESAVLVAMAF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRgcacLVTWSWVGGSFMGTVVTTA----IFNLTFCGPNEIHHFACHVPPLLKLACGENVLEV 196
Cdd:cd15952   97 DRYVAICNPLRYTTILTNK----VISVIALGIVLRPLLLVLPfvflILRLPFCGHNIIPHTYCEHMGIAKLACASIRINI 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 197 AKGVGIVCItaLLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEG--DTL 274
Cdd:cd15952  173 IYGLFAISV--LVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHNIPRyiHIL 250

                        250       260
                 ....*....|....*....|....
gi 255069790 275 MGITYTVLTPFLSPIIFSLRNKEL 298
Cdd:cd15952  251 LANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

41-298

1.44e-42

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 147.80 E-value: 1.44e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15953   17 GNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIMESAVLVAMAF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYN-VLMSPR----GCACLVTwswvgGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLE 195
Cdd:cd15953   97 DRYVAICNPLRYAtILTNSRiaklGLVGLIR-----GVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACGDTTIN 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 196 VAKGVgIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYG---FASVIYLKPKG-PKSLEg 271
Cdd:cd15953  172 RIYGL-VVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTpalFSFLTHRFGQGiAPHIH- 249

                        250       260
                 ....*....|....*....|....*..
gi 255069790 272 dTLMGITYTVLTPFLSPIIFSLRNKEL 298
Cdd:cd15953  250 -IILANLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

41-298

2.62e-42

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 147.05 E-value: 2.62e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFF-SFTFgFTHSFLLTVMG 119
Cdd:cd15221   17 GNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFvHFVF-VTESAILLAMA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 120 YDRYVAICHPLRYNVLMSPRgcacLVTWSWVGGSFMG-TVVTTAIF---NLTFCGPNEIHHFACHVPPLLKLACGENVLE 195
Cdd:cd15221   96 FDRYVAICYPLRYTTILTHS----VIGKIGVAAVARSfCIVFPFVFllkRLPYCGHNVIPHTYCEHMGIARLACADITVN 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 196 VAKGVgIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHY--GFASVIYLKPKGPKSLEGDT 273
Cdd:cd15221  172 IWYGL-TVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYtpAFFSFLTHRFGRHIPRHVHI 250

                        250       260
                 ....*....|....*....|....*
gi 255069790 274 LMGITYTVLTPFLSPIIFSLRNKEL 298
Cdd:cd15221  251 LLANLYVLVPPMLNPIVYGVKTKQI 275

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

41-298

5.77e-41

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 143.64 E-value: 5.77e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15951   17 GNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMESGIFVAMAL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLEVAKGV 200
Cdd:cd15951   97 DRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACADTRVSRAYGL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 gIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHY--GFASVIYLKPKGPKSLEGDTLMGIT 278
Cdd:cd15951  177 -SVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYipALFSFLTHRFGHNVPPHVHILIANV 255

                        250       260
                 ....*....|....*....|
gi 255069790 279 YTVLTPFLSPIIFSLRNKEL 298
Cdd:cd15951  256 YLLVPPMLNPIIYGVRTKQI 275

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

41-307

4.74e-37

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 133.40 E-value: 4.74e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790   41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:pfam13853  11 GNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAMAV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGEnvLEVAKGV 200
Cdd:pfam13853  91 DRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCAD--IKVNNIY 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  201 GIVCITALLGC-FLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHY----GFASVIYLKPKGPKSLEgdTLM 275
Cdd:pfam13853 169 GLFVVTSTFGIdSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYtpmiGLSMVHRFGHNVPPLLQ--IMM 246

                         250       260       270
                  ....*....|....*....|....*....|..
gi 255069790  276 GITYTVLTPFLSPIIFSLRNKELKNAMKKIFL 307
Cdd:pfam13853 247 ANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

41-298

5.66e-34

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 125.36 E-value: 5.66e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15956   17 GNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAMESGVLVAMAL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLEVAKGV 200
Cdd:cd15956   97 DRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACGATTVDSLYGL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 gIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYL----KPKGPKSLEgdTLMG 276
Cdd:cd15956  177 -ALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLmhrfGHSVPSAAH--VLLS 253

                        250       260
                 ....*....|....*....|..
gi 255069790 277 ITYTVLTPFLSPIIFSLRNKEL 298
Cdd:cd15956  254 NLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

41-298

3.07e-31

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 118.00 E-value: 3.07e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15954   17 GNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMESGVLMLMAL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLAC---------GE 191
Cdd:cd15954   97 DRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACanirvdaiyGL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 192 NVLEVAKGVGIVCITallgcfllilLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPK-GPKSLE 270
Cdd:cd15954  177 MVALLIGGFDILCIS----------VSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRfGGHHIT 246

                        250       260       270
                 ....*....|....*....|....*....|
gi 255069790 271 GDT--LMGITYTVLTPFLSPIIFSLRNKEL 298
Cdd:cd15954  247 PHIhiIMANLYLLLPPMMNPIVYGVKTKQI 276

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

41-298

4.00e-30

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 115.25 E-value: 4.00e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15955   17 GNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFESGILLAMAL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAI-FNLTFCGPNEIHHFACHVPPLLKLACGENVLEVAKG 199
Cdd:cd15955   97 DRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIkLRLHHFRSTVISHSYCEHMAVVKLAADDVRVNKIYG 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 200 VgIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDT--LMGI 277
Cdd:cd15955  177 L-FVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHHVAPYVhiLLSN 255

                        250       260
                 ....*....|....*....|.
gi 255069790 278 TYTVLTPFLSPIIFSLRNKEL 298
Cdd:cd15955  256 LYLLVPPVLNPIVYGVKTKQI 276

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

41-299

5.58e-30

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 115.00 E-value: 5.58e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15948   18 GNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMESAVLLAMAF 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLEVAKGV 200
Cdd:cd15948   98 DRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACGDTRFNNIYGI 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 gIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYG---FASVIYlKPKGPKSLEGDTLMGI 277
Cdd:cd15948  178 -AVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTpvvLSSTMH-RFARHVAPHVHILLAN 255

                        250       260
                 ....*....|....*....|..
gi 255069790 278 TYTVLTPFLSPIIFSLRNKELK 299
Cdd:cd15948  256 FYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

41-299

2.15e-27

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 108.33 E-value: 2.15e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15949   33 GNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSSNEIPLHACLLQMFLIHSFSAIESGIFLAMAF 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLKLACGENVLEVAKGV 200
Cdd:cd15949  113 DRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWYRTNIIAHSYCEHMAVVGLACGDVSINNHYGL 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 201 gIVCITALLGCFLLILLSYAFIVVTILKIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPKSLEGDT--LMGIT 278
Cdd:cd15949  193 -TIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAILAFYVPIAVSSLIHRFGQNVPPPThiLLANF 271

                        250       260
                 ....*....|....*....|.
gi 255069790 279 YTVLTPFLSPIIFSLRNKELK 299
Cdd:cd15949  272 YLLIPPMLNPIVYGVRTKQIQ 292

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

41-290

1.88e-24

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 99.29 E-value: 1.88e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790   41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLH-SIAFLACASQMFFSFTFGFTHSFLLTVMG 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  120 YDRYVAICHPLRYNVLMSPRGCACLVTWSWVGGS-------FMGTVVTTAIFNLTFCGPNEIHHFACHVPPLLklacgen 192
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALllslpplLFGWTLTVPEGNVTVCFIDFPEDLSKPVSYTL------- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  193 vlevakgvgIVCITALLGCFLLILLSYAFIVVTILKIPSAEGR-------HKAFSTCASHLTVVVVHYG------FASVI 259
Cdd:pfam00001 154 ---------LISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLpyhivnLLDSL 224

                         250       260       270
                  ....*....|....*....|....*....|.
gi 255069790  260 YLKPKGPKSLEGDTLMGITYTVLTPFLSPII 290
Cdd:pfam00001 225 ALDCELSRLLDKALSVTLWLAYVNSCLNPII 255

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

41-155

1.73e-16

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 77.71 E-value: 1.73e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd00637   15 GNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTAISV 94

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFM 155
Cdd:cd00637   95 DRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLL 129

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

41-156

7.62e-11

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 61.42 E-value: 7.62e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd14967   16 GNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCTASILNLCAISL 95

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMG 156
Cdd:cd14967   96 DRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLIS 131

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

42-160

1.48e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 54.61 E-value: 1.48e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  42 NLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLtVMGYD 121
Cdd:cd14972   16 NSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLASAYSLL-AIAVD 94

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 255069790 122 RYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVT 160
Cdd:cd14972   95 RYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPV 133

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

41-171

6.06e-08

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 53.28 E-value: 6.06e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISE-IFYTFAIIPRMLADLLSTLHSIAFLaCASQMFFSFTFGFTHSFLLTVMG 119
Cdd:cd15387   17 GNICVLLAIHTTRHKHSRMYFFMKHLSIADlVVAVFQVLPQLIWDITFRFYGPDFL-CRLVKYLQVVGMFASTYMLLLMS 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 255069790 120 YDRYVAICHPLRYnvlMSPRGCACLVTWSWVgGSFMGTVVTTAIFNLTFCGP 171
Cdd:cd15387   96 IDRCLAICQPLRS---LHRRSDRVYVLFSWL-LSLVFSIPQVHIFSLREVGN 143

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

41-149

6.73e-08

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 53.23 E-value: 6.73e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSI-AFLACASQMFFSFTFGFTHSFLLTVMG 119
Cdd:cd15005   17 GNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLFCFHSAFTLFCIA 96

                         90       100       110
                 ....*....|....*....|....*....|
gi 255069790 120 YDRYVAICHPLRYNVLMSPRGCACLVTWSW 149
Cdd:cd15005   97 VTRYMAIAHHRFYAKRMTFWTCLAVICMAW 126

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

41-171

9.70e-08

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 52.24 E-value: 9.70e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYT-FAIIPRMLADLLSTLHSIAFLaCASQMFFSFTFGFTHSFLLTVMG 119
Cdd:cd15196   17 GNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAlFNVLPQLIWDITYRFYGGDLL-CRLVKYLQVVGMYASSYVLVATA 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 255069790 120 YDRYVAICHPLRYNVLmSPRGCACLVTWSWVgGSFMGTVVTTAIFNLTFCGP 171
Cdd:cd15196   96 IDRYIAICHPLSSHRW-TSRRVHLMVAIAWV-LSLLLSIPQLFIFSYQEVGS 145

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

41-158

1.03e-07

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 52.26 E-value: 1.03e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPrmLADLLSTLHSIAFLACAsqMFFSFTFGFTHS--FLLTVM 118
Cdd:cd14968   17 GNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCL--FMACLVLVLTQSsiFSLLAI 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 255069790 119 GYDRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTV 158
Cdd:cd14968   93 AIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLT 132

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

41-150

1.26e-07

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 52.22 E-value: 1.26e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd14993   17 GNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQGVSVSASVLTLVAISI 96

                         90       100       110
                 ....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWV 150
Cdd:cd14993   97 DRYLAICYPLKARRVSTKRRARIIIVAIWV 126

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

41-150

3.21e-07

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 50.63 E-value: 3.21e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPrmladlLSTLHSIAF------LACASQMFFSFTFGFTHSFL 114
Cdd:cd15055   17 GNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMP------FSMIRSIETcwyfgdTFCKLHSSLDYILTSASIFN 90

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 255069790 115 LTVMGYDRYVAICHPLRYNVLMSPRGCACLVTWSWV 150
Cdd:cd15055   91 LVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWF 126

7tmA_GHSR-like

cd15928

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...

41-151

3.73e-07

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.

Pssm-ID: 320594 [Multi-domain] Cd Length: 288 Bit Score: 50.57 E-value: 3.73e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFyTFAIIPRMLADLL-STLHSIAFLACASQMFFSFTFGFTHSFLLTVMG 119
Cdd:cd15928   17 GNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLL-IFLVLPLDLYRLWrYRPWRFGDLLCRLMYFFSETCTYASILHITALS 95

                         90       100       110
                 ....*....|....*....|....*....|..
gi 255069790 120 YDRYVAICHPLRYNVLMSPRGCACLVTWSWVG 151
Cdd:cd15928   96 VERYLAICHPLRAKVLVTRGRVKLLIAVIWAV 127

7tmA_QRFPR

cd15205

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...

41-150

1.18e-06

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.

Pssm-ID: 320333 [Multi-domain] Cd Length: 298 Bit Score: 49.39 E-value: 1.18e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15205   17 GNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTAVVTSILTMTCIAV 96

                         90       100       110
                 ....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWV 150
Cdd:cd15205   97 ERHQGIVHPLKMKWQYTNRRAFTMLGLVWI 126

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

41-154

1.27e-06

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 49.13 E-value: 1.27e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd14969   17 LNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTLAALAF 96

                         90       100       110
                 ....*....|....*....|....*....|....
gi 255069790 121 DRYVAICHPLRYNVLmSPRGCACLVTWSWVGGSF 154
Cdd:cd14969   97 ERYLVIVRPLKAFRL-SKRRALILIAFIWLYGLF 129

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

41-131

4.17e-06

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 47.49 E-value: 4.17e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYT-FAIIPRMLADLLSTLHSIAFLaCASQMFFSFTFGFTHSFLLTVMG 119
Cdd:cd15386   17 GNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVAlFQVLPQLIWEITYRFQGPDLL-CRAVKYLQVLSMFASTYMLIMMT 95

                         90
                 ....*....|..
gi 255069790 120 YDRYVAICHPLR 131
Cdd:cd15386   96 VDRYIAVCHPLR 107

7tmA_Mel1C

cd15401

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...

41-150

7.74e-06

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320523 [Multi-domain] Cd Length: 279 Bit Score: 46.44 E-value: 7.74e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15401   17 GNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGLSVIGSVFNITAIAI 96

                         90       100       110
                 ....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWV 150
Cdd:cd15401   97 NRYCYICHSLRYDKLYNMKKTCCYVCLTWV 126

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

41-150

9.12e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 46.46 E-value: 9.12e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLL---STLHSIAFLACasqmffsFTFGFTHS--FLL 115
Cdd:cd15069   17 GNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLgfcTDFHSCLFLAC-------FVLVLTQSsiFSL 89

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 255069790 116 TVMGYDRYVAICHPLRYNVLMSPRGCACLVTWSWV 150
Cdd:cd15069   90 LAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWV 124

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

41-149

1.93e-05

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 45.42 E-value: 1.93e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15312   17 GNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFHLCFIAV 96

                         90       100
                 ....*....|....*....|....*....
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSW 149
Cdd:cd15312   97 DRYYAVCDPLHYRTKITTPVIKVFLVISW 125

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

41-149

2.35e-05

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 45.32 E-value: 2.35e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLS-TLHSIAFLACASQMFFSFTFGFTHSFLLTVMG 119
Cdd:cd15217   17 GNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNgSAWTYSVLSCKIVAFMAVLFCFHAAFMLFCIS 96

                         90       100       110
                 ....*....|....*....|....*....|
gi 255069790 120 YDRYVAICHPLRYNVLMSPRGCACLVTWSW 149
Cdd:cd15217   97 VTRYMAIAHHRFYSKRMTFWTCIAVICMVW 126

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

41-159

2.73e-05

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 44.98 E-value: 2.73e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFaIIPRMLADLLstLHSIAF--LACASQMFFSFTFGFTHSFLLTVM 118
Cdd:cd14970   17 GNSLVIYVILRYSKMKTVTNIYILNLAVADELFLL-GLPFLATSYL--LGYWPFgeVMCKIVLSVDAYNMFTSIFCLTVM 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 255069790 119 GYDRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVV 159
Cdd:cd14970   94 SVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPV 134

7tmA_alpha2B_AR

cd15321

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

41-155

3.10e-05

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320444 [Multi-domain] Cd Length: 268 Bit Score: 44.53 E-value: 3.10e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15321   23 GNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIVHLCAISL 102

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFM 155
Cdd:cd15321  103 DRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVI 137

7tmA_TACR_family

cd14992

tachykinin receptor and closely related proteins, member of the class A family of ...

41-150

3.86e-05

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320123 [Multi-domain] Cd Length: 291 Bit Score: 44.35 E-value: 3.86e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd14992   17 GNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLTAIAF 96

                         90       100       110
                 ....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWV 150
Cdd:cd14992   97 DRYFAIIHPLKPRHRQSYTTTVIIIITIWV 126

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

54-139

4.05e-05

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 44.55 E-value: 4.05e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  54 SLHTPMYLFLCALSISEIFYTFAIIPRMLADLL-----STLHSIAFLACASQMFFSFTFGFTHSFLLTVMGYDRYVAICH 128
Cdd:cd14978   29 SMRSSTNVYLAALAVSDILVLLSALPLFLLPYIadyssSFLSYFYAYFLPYIYPLANTFQTASVWLTVALTVERYIAVCH 108

                         90
                 ....*....|.
gi 255069790 129 PLRYNVLMSPR 139
Cdd:cd14978  109 PLKARTWCTPR 119

7tmA_NOFQ_opioid_R

cd15092

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...

41-156

4.60e-05

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320220 [Multi-domain] Cd Length: 279 Bit Score: 44.09 E-value: 4.60e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTI--WSEHSLHTPMYLFLCALSISEIFYTfaiIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVM 118
Cdd:cd15092   17 GNCLVMYVIlrHTKMKTATNIYIFNLALADTLVLLT---LPFQGTDIFLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAM 93

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 255069790 119 GYDRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMG 156
Cdd:cd15092   94 SVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVG 131

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

41-132

5.36e-05

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 44.08 E-value: 5.36e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15318   17 GNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLCFISI 96

                         90
                 ....*....|..
gi 255069790 121 DRYVAICHPLRY 132
Cdd:cd15318   97 DRHCAICDPLLY 108

7tmA_alpha2A_AR

cd15322

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

41-150

5.39e-05

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320445 [Multi-domain] Cd Length: 259 Bit Score: 43.78 E-value: 5.39e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15322   17 GNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISL 96

                         90       100       110
                 ....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWV 150
Cdd:cd15322   97 DRYWSITQAIEYNLKRTPRRIKCIIFIVWV 126

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

41-139

6.25e-05

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 43.88 E-value: 6.25e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYtfaIIPRMLADLLSTLHSIAFL----ACASQMFFSFTFGFTHSFLLT 116
Cdd:cd14979   17 GNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLI---LLVGLPVELYNFWWQYPWAfgdgGCKLYYFLFEACTYATVLTIV 93

                         90       100
                 ....*....|....*....|...
gi 255069790 117 VMGYDRYVAICHPLRYNVLMSPR 139
Cdd:cd14979   94 ALSVERYVAICHPLKAKTLVTKR 116

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

41-150

7.31e-05

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 43.77 E-value: 7.31e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLA---DLLSTLHSIAFLACasqmfFSFTFGFTHSFLLTV 117
Cdd:cd15068   17 GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITistGFCAACHGCLFIAC-----FVLVLTQSSIFSLLA 91

                         90       100       110
                 ....*....|....*....|....*....|...
gi 255069790 118 MGYDRYVAICHPLRYNVLMSPRGCACLVTWSWV 150
Cdd:cd15068   92 IAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWV 124

7tmA_Delta_opioid_R

cd15089

opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...

41-156

7.74e-05

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320217 [Multi-domain] Cd Length: 281 Bit Score: 43.40 E-value: 7.74e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTfAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15089   17 GNVLVMYGIVRYTKMKTATNIYIFNLALADALAT-STLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSV 95

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMG 156
Cdd:cd15089   96 DRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVG 131

7tmA_Mel1A

cd15402

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

41-150

8.01e-05

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320524 [Multi-domain] Cd Length: 279 Bit Score: 43.35 E-value: 8.01e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15402   17 GNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSVIGSIFNITGIAI 96

                         90       100       110
                 ....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWV 150
Cdd:cd15402   97 NRYCYICHSLKYDKLYSDKNSLCYVLLIWV 126

7tmA_Mu_opioid_R

cd15090

opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...

41-159

8.77e-05

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320218 [Multi-domain] Cd Length: 279 Bit Score: 43.44 E-value: 8.77e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTfAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15090   17 GNFLVMYVIVRYTKMKTATNIYIFNLALADALAT-STLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSV 95

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVV 159
Cdd:cd15090   96 DRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPV 134

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

41-150

9.66e-05

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 43.20 E-value: 9.66e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15317   17 GNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLCTTSIFHLCFIAI 96

                         90       100       110
                 ....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWV 150
Cdd:cd15317   97 DRYYAVCDPLRYPSKITVQVAWRFIAIGWL 126

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

42-158

1.21e-04

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 42.86 E-value: 1.21e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  42 NLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFA-IIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFL-----L 115
Cdd:cd15103   18 NILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSnALETIVIILLNNGYLVPRDSFEQHIDNVIDSMICSSLLasicsL 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 255069790 116 TVMGYDRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTV 158
Cdd:cd15103   98 LAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGIL 140

7tmA_MC2R_ACTH_R

cd15350

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...

42-153

1.34e-04

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320472 [Multi-domain] Cd Length: 270 Bit Score: 42.85 E-value: 1.34e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  42 NLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAiipRMLADLLSTLHSIAFL------------ACASQMFFSFTFGF 109
Cdd:cd15350   18 NLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLY---KTLENILIILADMGYLnrrgpfetklddIMDSLFCLSLLGSI 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 255069790 110 thsFLLTVMGYDRYVAICHPLRYNVLMSPR--GCACLVTWSWVGGS 153
Cdd:cd15350   95 ---FSILAIAADRYITIFHALRYHNIMTMRrtLVILAIIWTFCGGS 137

7tmA_V2R

cd15388

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...

41-130

2.54e-04

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320510 [Multi-domain] Cd Length: 295 Bit Score: 42.07 E-value: 2.54e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYT-FAIIPRMLADLLSTLHSIAFLaCASQMFFSFTFGFTHSFLLTVMG 119
Cdd:cd15388   17 SNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAfFQVLPQLVWDITDRFRGPDVL-CRLVKYLQVVGMFASSYMIVAMT 95

                         90
                 ....*....|.
gi 255069790 120 YDRYVAICHPL 130
Cdd:cd15388   96 FDRHQAICRPM 106

7tmA_alpha-2D_AR

cd15324

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

41-150

3.15e-04

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320447 [Multi-domain] Cd Length: 256 Bit Score: 41.39 E-value: 3.15e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15324   17 GNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTSSIVHLCAISL 96

                         90       100       110
                 ....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWV 150
Cdd:cd15324   97 DRYWSVTKAVSYNLKRTPKRIKRMIAVVWV 126

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

41-150

4.64e-04

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 41.19 E-value: 4.64e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISE-----IFYTFAIIPRMLA-------DLLSTLHSIAFLACasqmffsftfg 108
Cdd:cd15067   16 GNLLVILAVLRERYLRTVTNYFIVSLAVADllvgsIVMPFSILHEMTGgywlfgrDWCDVWHSFDVLAS----------- 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 255069790 109 fTHSFL-LTVMGYDRYVAICHPLRYNVLMSPRGCACLVTWSWV 150
Cdd:cd15067   85 -TASILnLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWI 126

7tmA_TACR-like

cd15202

tachykinin receptors and related receptors, member of the class A family of ...

41-131

6.34e-04

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320330 [Multi-domain] Cd Length: 288 Bit Score: 40.95 E-value: 6.34e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15202   17 GNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAYTLTAIAV 96

                         90
                 ....*....|.
gi 255069790 121 DRYVAICHPLR 131
Cdd:cd15202   97 DRYQAIMHPLK 107

7tmA_alpha2C_AR

cd15323

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...

41-150

6.76e-04

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320446 [Multi-domain] Cd Length: 261 Bit Score: 40.69 E-value: 6.76e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15323   17 GNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIVHLCAISL 96

                         90       100       110
                 ....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWV 150
Cdd:cd15323   97 DRYWSVTQAVEYNLKRTPRRVKAIIVTVWL 126

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

41-139

9.15e-04

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 40.41 E-value: 9.15e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLstLHSIAFLACASQMFFSFTFGF-THSFL-LTVM 118
Cdd:cd15065   16 GNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDL--LGYWLFGETFCNIWISFDVMCsTASILnLCAI 93

                         90       100
                 ....*....|....*....|.
gi 255069790 119 GYDRYVAICHPLRYNVLMSPR 139
Cdd:cd15065   94 SLDRYIHIKKPLKYERWMTTR 114

7tmA_alpha2_AR

cd15059

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...

41-150

1.04e-03

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320187 [Multi-domain] Cd Length: 261 Bit Score: 40.02 E-value: 1.04e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLstLHSIAFLACASQMFFSF-TFGFTHSFL-LTVM 118
Cdd:cd15059   17 GNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNEL--MGYWYFGSVWCEIWLALdVLFCTASIVnLCAI 94

                         90       100       110
                 ....*....|....*....|....*....|..
gi 255069790 119 GYDRYVAICHPLRYNVLMSPRGCACLVTWSWV 150
Cdd:cd15059   95 SLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWI 126

7tmA_TRH-R

cd14995

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...

41-150

1.10e-03

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.

Pssm-ID: 320126 [Multi-domain] Cd Length: 269 Bit Score: 40.06 E-value: 1.10e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISE-IFYTFAIIPRMLADLLSTLHSI-AFLACASQMFFSFTFGFTHSFLLTVM 118
Cdd:cd14995   17 GNIMVVLVVLRTRHMRTPTNCYLVSLAVADlMVLVAAGLPNEIESLLGPDSWIyGYAGCLLITYLQYLGINASSLSITAF 96

                         90       100       110
                 ....*....|....*....|....*....|..
gi 255069790 119 GYDRYVAICHPLRYNVLMSPRGCACLVTWSWV 150
Cdd:cd14995   97 TIERYIAICHPMKAQFICTVSRAKKIICFVWI 128

7tmA_GnRHR-like

cd15195

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...

41-179

1.29e-03

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320323 [Multi-domain] Cd Length: 293 Bit Score: 39.69 E-value: 1.29e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPrMLADLLSTLHSIAFLACASQMFFSFTFG-FTHSFLLTVMG 119
Cdd:cd15195   17 GNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMP-MDAVWNYTVEWLAGDLMCRVMMFLKQFGmYLSSFMLVVIA 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790 120 YDRYVAICHPLryNVLMSPRGCACLVTWSWVgGSFMGTVVTTAIFNLTFCGPNEIHHFAC 179
Cdd:cd15195   96 LDRVFAILSPL--SANQARKRVKIMLTVAWV-LSALCSIPQSFIFSVLRKMPEQPGFHQC 152

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

42-161

1.45e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 39.78 E-value: 1.45e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  42 NLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY- 120
Cdd:cd15351   18 NILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMDNVIDTMICSSVVSSLSFl 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 255069790 121 -----DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMGTVVTT 161
Cdd:cd15351   98 gaiavDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIV 143

7tmA_Kappa_opioid_R

cd15091

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...

41-156

1.61e-03

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320219 [Multi-domain] Cd Length: 282 Bit Score: 39.55 E-value: 1.61e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTfAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15091   17 GNSLVMFVIIRYTKMKTATNIYIFNLALADALVT-TTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSV 95

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWVGGSFMG 156
Cdd:cd15091   96 DRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVG 131

7tmA_AstC_insect

cd15094

somatostatin-like receptor for allatostatin C, member of the class A family of ...

109-148

1.65e-03

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.

Pssm-ID: 320222 [Multi-domain] Cd Length: 282 Bit Score: 39.38 E-value: 1.65e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 255069790 109 FTHSFLLTVMGYDRYVAICHPLRYNVLMSPR--GCACLVTWS 148
Cdd:cd15094   84 FTSSFTLTVMSADRYLAVCHPIRSMRYRTPFiaKVVCATTWS 125

7tmA_Gal1_R

cd15098

galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...

61-172

2.07e-03

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320226 [Multi-domain] Cd Length: 282 Bit Score: 39.32 E-value: 2.07e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  61 LFLCALSISEIFYTFAIIPrmladLLSTLHSI------AFLaCASQMFFSFTFGFTHSFLLTVMGYDRYVAICHPLRYNV 134
Cdd:cd15098   39 VFILNLSIADLFFLLFCVP-----FQATIYSLpewvfgAFM-CKFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSS 112

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 255069790 135 LMSPRGC--ACLVTWSWVGGSFMGTVVTTAIF------NLTFCGPN 172
Cdd:cd15098  113 LRTRRNAllGVLVIWVLSLAMASPVAVHQDLVhhwtasNQTFCWEN 158

7tmA_AKHR

cd15382

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...

41-151

2.36e-03

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320504 [Multi-domain] Cd Length: 298 Bit Score: 39.22 E-value: 2.36e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIW-SEHSLHTPMYLFLCALSISEIFYTFAIIPrmladlLSTLHSIAF------LACASQMFFSfTFG-FTHS 112
Cdd:cd15382   17 GNLTVLLILLrNRRRKRSRVNILLMHLAIADLLVTFIMMP------LEIGWAATVawlagdFLCRLMLFFR-AFGlYLSS 89

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 255069790 113 FLLTVMGYDRYVAICHPLRynVLMSPRGCACLVTWSWVG 151
Cdd:cd15382   90 FVLVCISLDRYFAILKPLR--LSDARRRGRIMLAVAWVI 126

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

41-149

2.40e-03

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 38.95 E-value: 2.40e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15050   17 LNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSLFILCI 96

                         90       100
                 ....*....|....*....|....*....
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSW 149
Cdd:cd15050   97 DRYRSVQQPLKYLKYRTKTRASLMISGAW 125

7tmA_GPR83

cd15389

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...

41-155

2.70e-03

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.

Pssm-ID: 320511 [Multi-domain] Cd Length: 285 Bit Score: 38.86 E-value: 2.70e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15389   17 GNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVSTLTLTAIAL 96

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 255069790 121 DRYVAICHPLRYNvlMSPRGCACLVTWSWVGGSFM 155
Cdd:cd15389   97 DRHRVILHPLKPR--ITPCQGVVVIAIIWIMASCL 129

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

41-131

2.93e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 38.65 E-value: 2.93e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYT-FAIIPRMLADLLSTLHSIAFLaCASQMFFSFTFGFTHSFLLTVMG 119
Cdd:cd15385   17 GNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAfFQVLPQLCWDITYRFYGPDFL-CRIVKHLQVLGMFASTYMLVMMT 95

                         90
                 ....*....|..
gi 255069790 120 YDRYVAICHPLR 131
Cdd:cd15385   96 ADRYIAICHPLK 107

7tmA_Prostanoid_R

cd14981

G protein-coupled receptors for prostanoids, member of the class A family of ...

57-139

3.26e-03

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320112 [Multi-domain] Cd Length: 288 Bit Score: 38.77 E-value: 3.26e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  57 TPMYLFLCALSISEIFYTFAIIPRMLAdlLSTLHSIAFLACASQMFFSFT---FGFTHSFLLTVMGYDRYVAICHPLRYN 133
Cdd:cd14981   35 SVFYRLVAGLAITDLLGILLTSPVVLA--VYASNFEWDGGQPLCDYFGFMmsfFGLSSLLIVCAMAVERFLAITHPFFYN 112


                 ....*.
gi 255069790 134 VLMSPR 139
Cdd:cd14981  113 SHVKKR 118

7tmA_Opsin_Gq_invertebrates

cd15337

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...

41-156

3.39e-03

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320459 [Multi-domain] Cd Length: 292 Bit Score: 38.46 E-value: 3.39e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEifYTFAII---PRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTV 117
Cdd:cd15337   17 GNLLVIYLFSKTKSLRTPSNMFIINLAISD--FGFSAVngfPLKTISSFNKKWIWGKVACELYGFAGGIFGFMSITTLAA 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 255069790 118 MGYDRYVAICHPLRYNVLMSPRGcACLV-----TWS--WVGGSFMG 156
Cdd:cd15337   95 ISIDRYLVIAKPLEAMKKMTFKR-AFIMiiiiwLWSllWSIPPFFG 139

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

41-164

3.41e-03

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 38.51 E-value: 3.41e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTF-AIIPRMLADLLSTLHSIAFLaCASQMFFSFTFGFTHSFLLTVMG 119
Cdd:cd14986   17 GNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFfTVLTQIIWEATGEWVAGDVL-CRIVKYLQVVGLFASTYILVSMS 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 255069790 120 YDRYVAICHPLRynVLMSPRGCACLVTWSWVgGSFMGTVVTTAIF 164
Cdd:cd14986   96 LDRYQAIVKPMS--SLKPRKRARLMIVVAWV-LSFLFSIPQLVIF 137

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

41-149

3.41e-03

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 38.47 E-value: 3.41e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15083   17 GNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTLAAIAV 96

                         90       100       110
                 ....*....|....*....|....*....|.
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCA--CLVTWSW 149
Cdd:cd15083   97 DRYLVITRPMKASVRISHRRALivIAVVWLY 127

7tmA_Mel1

cd15209

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...

41-150

3.59e-03

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320337 [Multi-domain] Cd Length: 279 Bit Score: 38.61 E-value: 3.59e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15209   17 GNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSIFNITAIAI 96

                         90       100       110
                 ....*....|....*....|....*....|
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWV 150
Cdd:cd15209   97 NRYCYICHSLQYDRLYSLRNTCCYLCLTWL 126

7tmA_PrRP_R

cd15394

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...

41-150

4.15e-03

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.

Pssm-ID: 320516 [Multi-domain] Cd Length: 286 Bit Score: 38.18 E-value: 4.15e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSI-AFLACASQMFFSFTFGFTHSFLLTVMG 119
Cdd:cd15394   17 GNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRGWVfGRFMCYFVFLMQPVTVYVSVFTLTAIA 96

                         90       100       110
                 ....*....|....*....|....*....|.
gi 255069790 120 YDRYVAICHPLRYNvlMSPRGCACLVTWSWV 150
Cdd:cd15394   97 VDRYYVTVYPLRRR--ISRRTCAYIVAAIWL 125

7tmA_OXR

cd15208

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

41-132

4.16e-03

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.

Pssm-ID: 320336 [Multi-domain] Cd Length: 303 Bit Score: 38.14 E-value: 4.16e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIP-RMLADLLSTLHsIAFLACASQMFFSFTFGFTHSFLLTVMG 119
Cdd:cd15208   17 GNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPaTLLVDVTETWF-FGQVLCKIIPYLQTVSVSVSVLTLSCIA 95

                         90
                 ....*....|...
gi 255069790 120 YDRYVAICHPLRY 132
Cdd:cd15208   96 LDRWYAICHPLMF 108

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

41-131

6.40e-03

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 37.65 E-value: 6.40e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLStlHSIAFLA---CASQMFFSFTfgFTHSFLLTV 117
Cdd:cd14997   17 GNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWA--REPWLLGefmCKLVPFVELT--VAHASVLTI 92

                         90
                 ....*....|....*.
gi 255069790 118 M--GYDRYVAICHPLR 131
Cdd:cd14997   93 LaiSFERYYAICHPLQ 108

7tmA_SREB1_GPR27

cd15216

super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of ...

41-149

7.04e-03

super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320344 [Multi-domain] Cd Length: 332 Bit Score: 37.70 E-value: 7.04e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPR-MLADLLSTLHSIA---FLACASQMFFSFTFGFTHSFLLT 116
Cdd:cd15216   17 GNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAvMLAARRAAAAAGTppgALGCKLLAFLAALFCFHAAFLLL 96

                         90       100       110
                 ....*....|....*....|....*....|....
gi 255069790 117 VMGYDRYVAICHPLRYNVLMSPRGCAC-LVTWSW 149
Cdd:cd15216   97 GVGVTRYLAIAHHRFYAERLAGWPCAAmLVCAAW 130

7tmA_Gal2_Gal3_R

cd15097

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...

41-149

7.32e-03

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320225 [Multi-domain] Cd Length: 279 Bit Score: 37.50 E-value: 7.32e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIW-SEHSLHTPMYLFLCALSISEIFYTFAIIPrmLADLLSTLHSIAF--LACASQMFFSFTFGFTHSFLLTV 117
Cdd:cd15097   17 GNSLVLAVLLrSGQSGHNTTNLFILNLSVADLCFILFCVP--FQATIYSLEGWVFgsFLCKAVHFFIYLTMYASSFTLAA 94

                         90       100       110
                 ....*....|....*....|....*....|..
gi 255069790 118 MGYDRYVAICHPLRYNVLMSPRGCACLVTWSW 149
Cdd:cd15097   95 VSVDRYLAIRYPLRSRELRTPRNAVAAIALIW 126

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

41-150

9.11e-03

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 36.92 E-value: 9.11e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACasQMFFSF-TFGFTHSFL-LTVM 118
Cdd:cd15064   17 GNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLC--DIWISLdVTCCTASILhLCVI 94

                         90       100       110
                 ....*....|....*....|....*....|..
gi 255069790 119 GYDRYVAICHPLRYNVLMSPRGCACLVTWSWV 150
Cdd:cd15064   95 ALDRYWAITDAVEYAHKRTPKRAAVMIALVWT 126

7tmA_GHSR

cd15131

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...

41-149

9.74e-03

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.

Pssm-ID: 320259 [Multi-domain] Cd Length: 291 Bit Score: 37.17 E-value: 9.74e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15131   17 GNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSESCTYSTILNITALSV 96

                         90       100
                 ....*....|....*....|....*....
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSW 149
Cdd:cd15131   97 ERYFAICFPLRAKVVVTKRRVKLVILVLW 125

7tmA_GPBAR1

cd15905

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...

42-151

9.79e-03

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.

Pssm-ID: 320571 [Multi-domain] Cd Length: 272 Bit Score: 37.04 E-value: 9.79e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  42 NLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAI--IPRMLADLLSTLHSIAFLACASQMFF-SFTFGfthsflLTVM 118
Cdd:cd15905   16 NLFIILGIACNRKLHNTANYFFLSLLLADLLTGVALpfIPGMSNESRRGYHSCLFVYVAPNFLFlSFLAN------LLMV 89

                         90       100       110
                 ....*....|....*....|....*....|...
gi 255069790 119 GYDRYVAICHPLRYNVLMSPRGCACLVTWSWVG 151
Cdd:cd15905   90 HYERYLCIVYPLQYHNFWVHRWVPLALLLTWAL 122

7tmA_NPR-like_invertebrate

cd15391

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...

41-163

9.86e-03

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.

Pssm-ID: 320513 [Multi-domain] Cd Length: 289 Bit Score: 37.11 E-value: 9.86e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069790  41 GNLLIMTTIWSEHSLHTPMYLFLCALSISEIFYTFAIIPRMLADLLSTLHSIAFLACASQMFFSFTFGFTHSFLLTVMGY 120
Cdd:cd15391   17 GNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAIGI 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 255069790 121 DRYVAICHPLRYNVLMSPRGCACLVTWSWvggSFMGTVVTTAI 163
Cdd:cd15391   97 DRFFAVIFPLRSRHTKSRTKCIIASIWAI---SFSLSSVQLFA 136

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01