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Conserved domains on  [gi|46402263|ref|NP_997138|]
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zinc finger protein 532 isoform 2 [Mus musculus]

Protein Classification

zf-C2H2_11 and zf-C2H2_6 domain-containing protein( domain architecture ID 11244371)

protein containing domains PTZ00108, zf-C2H2_11, and zf-C2H2_6

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-C2H2_11 pfam16622
zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.
 936-962 1.53e-11

zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.


:

Pssm-ID: 465205  Cd Length: 27  Bit Score: 59.36  E-value: 1.53e-11
                           10        20
                   ....*....|....*....|....*..
gi 46402263    936 SSHQCRECGLCYTSHGSLARHLFIVHK 962
Cdd:pfam16622    1 STCQCLLCGLCFTSQGSLSRHLFIVHK 27
zf-C2H2_6 pfam13912
C2H2-type zinc finger;
1000-1021 1.42e-03

C2H2-type zinc finger;


:

Pssm-ID: 433576  Cd Length: 27  Bit Score: 36.84  E-value: 1.42e-03
                           10        20
                   ....*....|....*....|..
gi 46402263   1000 KCKVCAKTFETEAALNTHMRTH 1021
Cdd:pfam13912    3 ECSECGKSFPSYQALGGHKKSH 24
PTZ00108 super family cl36510
DNA topoisomerase 2-like protein; Provisional
 136-371 1.94e-03

DNA topoisomerase 2-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00108:

Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 42.34  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402263   136 EEFEDDEKIEVDDPpDKEEARAGFRSNVLTGSAPQQDFDKLKALGgensSKTGVSTSGHTDKNKVKREAESNSITLSVYE 215
Cdd:PTZ00108 1139 EALEEQEEVEEKEI-AKEQRLKSKTKGKASKLRKPKLKKKEKKKK----KSSADKSKKASVVGNSKRVDSDEKRKLDDKP 1213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402263   216 PFKVRKAEDKLKENSEKMLESRVLDGKPSSEKSDSGIAAAASSKTKPSSKLSSCIAAIAALSAKKAASDSCKEPvaNSRE 295
Cdd:PTZ00108 1214 DNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPP--PSKR 1291

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 46402263   296 ASPlPKEVNDSPKAADKSPEsQNLIDGTKKASLKPSDSPRSVSSENSSKGSPSSPVGSTPAIPKVRIKTIKTSSGE 371
Cdd:PTZ00108 1292 PDG-ESNGGSKPSSPTKKKV-KKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSS 1365
 
Name Accession Description Interval E-value
zf-C2H2_11 pfam16622
zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.
 936-962 1.53e-11

zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.


Pssm-ID: 465205  Cd Length: 27  Bit Score: 59.36  E-value: 1.53e-11
                           10        20
                   ....*....|....*....|....*..
gi 46402263    936 SSHQCRECGLCYTSHGSLARHLFIVHK 962
Cdd:pfam16622    1 STCQCLLCGLCFTSQGSLSRHLFIVHK 27
zf-C2H2_6 pfam13912
C2H2-type zinc finger;
1000-1021 1.42e-03

C2H2-type zinc finger;


Pssm-ID: 433576  Cd Length: 27  Bit Score: 36.84  E-value: 1.42e-03
                           10        20
                   ....*....|....*....|..
gi 46402263   1000 KCKVCAKTFETEAALNTHMRTH 1021
Cdd:pfam13912    3 ECSECGKSFPSYQALGGHKKSH 24
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 136-371 1.94e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 42.34  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402263   136 EEFEDDEKIEVDDPpDKEEARAGFRSNVLTGSAPQQDFDKLKALGgensSKTGVSTSGHTDKNKVKREAESNSITLSVYE 215
Cdd:PTZ00108 1139 EALEEQEEVEEKEI-AKEQRLKSKTKGKASKLRKPKLKKKEKKKK----KSSADKSKKASVVGNSKRVDSDEKRKLDDKP 1213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402263   216 PFKVRKAEDKLKENSEKMLESRVLDGKPSSEKSDSGIAAAASSKTKPSSKLSSCIAAIAALSAKKAASDSCKEPvaNSRE 295
Cdd:PTZ00108 1214 DNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPP--PSKR 1291

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 46402263   296 ASPlPKEVNDSPKAADKSPEsQNLIDGTKKASLKPSDSPRSVSSENSSKGSPSSPVGSTPAIPKVRIKTIKTSSGE 371
Cdd:PTZ00108 1292 PDG-ESNGGSKPSSPTKKKV-KKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSS 1365
ZnF_C2H2 smart00355
zinc finger;
1000-1021 3.74e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.90  E-value: 3.74e-03
                            10        20
                    ....*....|....*....|..
gi 46402263    1000 KCKVCAKTFETEAALNTHMRTH 1021
Cdd:smart00355    2 RCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
zf-C2H2_11 pfam16622
zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.
 936-962 1.53e-11

zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.


Pssm-ID: 465205  Cd Length: 27  Bit Score: 59.36  E-value: 1.53e-11
                           10        20
                   ....*....|....*....|....*..
gi 46402263    936 SSHQCRECGLCYTSHGSLARHLFIVHK 962
Cdd:pfam16622    1 STCQCLLCGLCFTSQGSLSRHLFIVHK 27
zf-C2H2_6 pfam13912
C2H2-type zinc finger;
1000-1021 1.42e-03

C2H2-type zinc finger;


Pssm-ID: 433576  Cd Length: 27  Bit Score: 36.84  E-value: 1.42e-03
                           10        20
                   ....*....|....*....|..
gi 46402263   1000 KCKVCAKTFETEAALNTHMRTH 1021
Cdd:pfam13912    3 ECSECGKSFPSYQALGGHKKSH 24
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 136-371 1.94e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 42.34  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402263   136 EEFEDDEKIEVDDPpDKEEARAGFRSNVLTGSAPQQDFDKLKALGgensSKTGVSTSGHTDKNKVKREAESNSITLSVYE 215
Cdd:PTZ00108 1139 EALEEQEEVEEKEI-AKEQRLKSKTKGKASKLRKPKLKKKEKKKK----KSSADKSKKASVVGNSKRVDSDEKRKLDDKP 1213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402263   216 PFKVRKAEDKLKENSEKMLESRVLDGKPSSEKSDSGIAAAASSKTKPSSKLSSCIAAIAALSAKKAASDSCKEPvaNSRE 295
Cdd:PTZ00108 1214 DNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPP--PSKR 1291

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 46402263   296 ASPlPKEVNDSPKAADKSPEsQNLIDGTKKASLKPSDSPRSVSSENSSKGSPSSPVGSTPAIPKVRIKTIKTSSGE 371
Cdd:PTZ00108 1292 PDG-ESNGGSKPSSPTKKKV-KKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSS 1365
ZnF_C2H2 smart00355
zinc finger;
1000-1021 3.74e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.90  E-value: 3.74e-03
                            10        20
                    ....*....|....*....|..
gi 46402263    1000 KCKVCAKTFETEAALNTHMRTH 1021
Cdd:smart00355    2 RCPECGKVFKSKSALREHMRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1000-1021 3.80e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 3.80e-03
                           10        20
                   ....*....|....*....|..
gi 46402263   1000 KCKVCAKTFETEAALNTHMRTH 1021
Cdd:pfam00096    2 KCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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