NCBI Conserved Domain Search

Conserved domains on [gi|283135120|ref|NP_997441|]

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olfactory receptor 750 [Mus musculus]

Protein Classification

olfactory receptor( domain architecture ID 11610373)

olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

29-297

6.47e-159

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 445.00 E-value: 6.47e-159

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15912    3 LFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLL 188
Cdd:cd15912   83 LGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPN-VINHFFCDSGPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 189 HLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQS 268
Cdd:cd15912  162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQS 241

                        250       260
                 ....*....|....*....|....*....
gi 283135120 269 GSVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15912  242 SSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

Name

Accession

Description

Interval

E-value

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

29-297

6.47e-159

Pssm-ID: 320578 Cd Length: 270 Bit Score: 445.00 E-value: 6.47e-159

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15912    3 LFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLL 188
Cdd:cd15912   83 LGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPN-VINHFFCDSGPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 189 HLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQS 268
Cdd:cd15912  162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQS 241

                        250       260
                 ....*....|....*....|....*....
gi 283135120 269 GSVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15912  242 SSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

33-308

5.67e-41

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 144.18 E-value: 5.67e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120   33 FLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGAS 112
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  113 EFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLHLAC 192
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHH-VLSHSYCLHMGLARLSC 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  193 TNTTrleeADFVLAFLVIMSSLTITG----ASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYV--RPS 266
Cdd:pfam13853 160 ADIK----VNNIYGLFVVTSTFGIDSllivLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFG 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 283135120  267 QSGSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEALKEMF 308
Cdd:pfam13853 236 HNVPPLLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

PHA03087

G protein-coupled chemokine receptor-like protein; Provisional

23-134

1.29e-04

G protein-coupled chemokine receptor-like protein; Provisional

Pssm-ID: 222976 [Multi-domain] Cd Length: 335 Bit Score: 43.23 E-value: 1.29e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  23 NSTGAEVFSVFLFVylLTLTGNtLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIiPKMLSNFLSRRHTISFAACITQ 102
Cdd:PHA03087  39 NSTILIVVYSTIFF--FGLVGN-IIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTL-PFQIYYYILFQWSFGEFACKIV 114

                         90       100       110
                 ....*....|....*....|....*....|..
gi 283135120 103 FYFYFFLGASEFLLLAVMSVDRYLAICRPLHY 134
Cdd:PHA03087 115 SGLYYIGFYNSMNFITVMSVDRYIAIVHPVKS 146

Name

Accession

Description

Interval

E-value

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

29-297

6.47e-159

Pssm-ID: 320578 Cd Length: 270 Bit Score: 445.00 E-value: 6.47e-159

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15912    3 LFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLL 188
Cdd:cd15912   83 LGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPN-VINHFFCDSGPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 189 HLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQS 268
Cdd:cd15912  162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQS 241

                        250       260
                 ....*....|....*....|....*....
gi 283135120 269 GSVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15912  242 SSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

30-297

7.93e-136

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 386.45 E-value: 7.93e-136

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd13954    4 FVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQgAVVQHFFCDSGPLLH 189
Cdd:cd13954   84 GGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGS-NVINHFFCDIPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd13954  163 LSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSSY 242

                        250       260
                 ....*....|....*....|....*...
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd13954  243 SSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

30-304

2.89e-131

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 375.25 E-value: 2.89e-131

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15225    4 FVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCkQGAVVQHFFCDSGPLLH 189
Cdd:cd15225   84 GGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFC-GSNEINHFFCDIPPVLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15225  163 LACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSY 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15225  243 SPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

30-297

5.36e-126

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 361.42 E-value: 5.36e-126

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15911    4 FLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15911   84 AATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPN-EIDHFFCDFAPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15911  163 LSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNT 242

                        250       260
                 ....*....|....*....|....*...
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15911  243 SRDLNKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

30-297

2.74e-112

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 326.93 E-value: 2.74e-112

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15224    4 FLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15224   84 ACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPN-VINHFFCDISPLLN 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15224  163 LSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAIS 242

                        250       260
                 ....*....|....*....|....*...
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15224  243 SFDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

30-297

4.99e-112

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 326.00 E-value: 4.99e-112

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15230    4 FVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15230   84 GTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSN-VINHFFCDIPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15230  163 LSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSY 242

                        250       260
                 ....*....|....*....|....*...
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15230  243 SLDQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

29-304

1.18e-107

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 315.36 E-value: 1.18e-107

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15231    3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCkQGAVVQHFFCDSGPLL 188
Cdd:cd15231   83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFC-GSNQISHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 189 HLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQS 268
Cdd:cd15231  162 KLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSG 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 283135120 269 GSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15231  242 YSLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

29-304

6.42e-106

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 310.64 E-value: 6.42e-106

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15421    3 LFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCkQGAVVQHFFCDSGPLL 188
Cdd:cd15421   83 LGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYC-GSREIHHFFCEVPALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 189 HLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQS 268
Cdd:cd15421  162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 283135120 269 GSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15421  242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

30-304

2.19e-105

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 309.54 E-value: 2.19e-105

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15235    5 FLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQgAVVQHFFCDSGPLLH 189
Cdd:cd15235   85 GNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGS-NEIPHFFCDLQPLLK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15235  164 LSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSSY 243

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15235  244 SADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

30-297

7.19e-105

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 307.84 E-value: 7.19e-105

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15227    4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCkQGAVVQHFFCDSGPLLH 189
Cdd:cd15227   84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFC-GSNVIHQFFCDIPQLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15227  163 LSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDS 242

                        250       260
                 ....*....|....*....|....*...
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15227  243 PSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

30-297

1.17e-104

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 307.23 E-value: 1.17e-104

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15918    4 FGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15918   84 GDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASN-EIPHFFCDLNPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15918  163 LSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSH 242

                        250       260
                 ....*....|....*....|....*...
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15918  243 SASKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

30-297

1.14e-102

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 302.27 E-value: 1.14e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15237    4 FILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15237   84 GVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPN-HINHFFCEAPAVLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15237  163 LACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTH 242

                        250       260
                 ....*....|....*....|....*...
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15237  243 SPDQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

29-305

2.06e-102

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 301.93 E-value: 2.06e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15411    3 LFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCkQGAVVQHFFCDSGPLL 188
Cdd:cd15411   83 LATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFC-GSNVINHFFCDTPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 189 HLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQS 268
Cdd:cd15411  162 KLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 283135120 269 GSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEALK 305
Cdd:cd15411  242 YSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALR 278

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

30-297

2.79e-100

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 296.06 E-value: 2.79e-100

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15431    4 FVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPtVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15431   84 GITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIP-VLTMPLHFCGPN-VINHFFCEVQALLK 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15431  162 LACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKS 241

                        250       260
                 ....*....|....*....|....*...
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15431  242 SSDQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

30-304

4.33e-100

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 296.05 E-value: 4.33e-100

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15229    4 FLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15229   84 AGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPN-EINHFSCELPSLLP 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15229  163 LSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSAS 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15229  243 SSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

14-301

5.08e-100

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 296.15 E-value: 5.08e-100

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  14 FVLAGFPNLNSTGAEVFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHT 93
Cdd:cd15408    1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  94 ISFAACITQFYFYFFLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQ 173
Cdd:cd15408   81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 174 GaVVQHFFCDSGPLLHLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTL 253
Cdd:cd15408  161 N-VINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTL 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 283135120 254 FYGSAIFLYVRPSQSGSVDTNWSVTVITTFVTPLLNPFIYALRNDQVK 301
Cdd:cd15408  240 FYGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

30-305

1.04e-99

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 294.94 E-value: 1.04e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15417    4 FVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15417   84 GLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPN-VIDHFFCDIPPLLS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15417  163 LSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSH 242

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEALK 305
Cdd:cd15417  243 SQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALK 278

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

13-308

5.32e-99

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 293.89 E-value: 5.32e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  13 EFVLAGFPNLNSTGAEVFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRH 92
Cdd:cd15943    1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  93 TISFAACITQFYFYFFLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCK 172
Cdd:cd15943   81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 173 QGaVVQHFFCDSGPLLHLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVT 252
Cdd:cd15943  161 SN-VINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVT 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 283135120 253 LFYGSAIFLYVRPSQSGSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEALKEMF 308
Cdd:cd15943  240 IFYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

30-297

6.38e-99

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 292.68 E-value: 6.38e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15913    4 FSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15913   84 GTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPN-IIDHFLCDPGPLLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15913  163 LSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGN 242

                        250       260
                 ....*....|....*....|....*...
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15913  243 STGMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

30-297

4.93e-97

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 287.98 E-value: 4.93e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15947    4 FVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQgAVVQHFFCDSGPLLH 189
Cdd:cd15947   84 GSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGH-HTLDHFFCEVPALIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15947  163 LACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSY 242

                        250       260
                 ....*....|....*....|....*...
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15947  243 SQDQGKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

29-297

4.56e-95

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 283.04 E-value: 4.56e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15915    3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCkQGAVVQHFFCDSGPLL 188
Cdd:cd15915   83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFC-GPNKINHFFCDIKPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 189 HLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIP-SASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQ 267
Cdd:cd15915  162 KLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSS 241

                        250       260       270
                 ....*....|....*....|....*....|
gi 283135120 268 SGSVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15915  242 GDSLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

30-304

5.10e-95

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 283.14 E-value: 5.10e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15429    4 FVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQgAVVQHFFCDSGPLLH 189
Cdd:cd15429   84 GGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGH-NTINHFSCELLAVVR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15429  163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15429  243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

30-297

1.41e-93

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 279.26 E-value: 1.41e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15914    4 FILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGAvVQHFFCDSGPLLH 189
Cdd:cd15914   84 GITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQ-IQHIFCDFPPLLS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15914  163 LACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSY 242

                        250       260
                 ....*....|....*....|....*...
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15914  243 SLDYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

14-308

9.31e-93

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 278.00 E-value: 9.31e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  14 FVLAGFPNLNSTGAEVFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHT 93
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  94 ISFAACITQFYFYFFLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKq 173
Cdd:cd15410   81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCG- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 174 GAVVQHFFCDSGPLLHLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTL 253
Cdd:cd15410  160 SNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITI 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 283135120 254 FYGSAIFLYVRPSQSGSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEALKEMF 308
Cdd:cd15410  240 FHGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

30-305

9.90e-93

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 277.27 E-value: 9.90e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15419    4 FLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15419   84 GTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSN-EIDHFFCDVPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15419  163 LSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVS 242

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEALK 305
Cdd:cd15419  243 SPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALK 278

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

30-305

1.79e-92

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 276.59 E-value: 1.79e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15412    4 FVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQgAVVQHFFCDSGPLLH 189
Cdd:cd15412   84 VITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGS-NVINHFYCADPPLIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15412  163 LSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEE 242

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEALK 305
Cdd:cd15412  243 SVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALK 278

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

30-297

8.67e-91

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 272.21 E-value: 8.67e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15232    4 FWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15232   84 LGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPN-IINHFFCEIPPLLL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15232  163 LSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSY 242

                        250       260
                 ....*....|....*....|....*...
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15232  243 SPEKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

29-304

4.70e-90

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 270.41 E-value: 4.70e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15434    3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQgAVVQHFFCDSGPLL 188
Cdd:cd15434   83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGH-HRVDHFFCEMPALI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 189 HLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQS 268
Cdd:cd15434  162 KLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 283135120 269 GSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15434  242 VSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

30-304

5.00e-89

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 268.04 E-value: 5.00e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15420    4 FGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQgAVVQHFFCDSGPLLH 189
Cdd:cd15420   84 AHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGP-NEVNHFFCEILAVLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15420  163 LACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15420  243 SAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

30-305

8.57e-89

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 267.31 E-value: 8.57e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15416    4 FVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15416   84 GTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPN-EINHFFCDFPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15416  163 LSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSY 242

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEALK 305
Cdd:cd15416  243 SMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALK 278

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

30-305

1.06e-88

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 267.27 E-value: 1.06e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15413    4 FGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCkQGAVVQHFFCDSGPLLH 189
Cdd:cd15413   84 IISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFC-GSNVINHFYCDDLPLLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15413  163 LSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSH 242

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEALK 305
Cdd:cd15413  243 SLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALK 278

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

30-305

1.15e-88

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 266.97 E-value: 1.15e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15409    4 FLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15409   84 ATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSN-EINHFFCDIPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLA-FLVIMSSLTITgASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQS 268
Cdd:cd15409  163 ISCTDPSINELVLFIFSgSIQVFTILTVL-ISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSL 241

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 283135120 269 GSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEALK 305
Cdd:cd15409  242 YALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALR 278

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

30-305

1.13e-86

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 261.96 E-value: 1.13e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15415    4 FMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15415   84 VTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPN-VINHYFCDIPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15415  163 LSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQY 242

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEALK 305
Cdd:cd15415  243 SLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALK 278

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

14-305

1.19e-86

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 262.37 E-value: 1.19e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  14 FVLAGFPNLNSTGAEVFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHT 93
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  94 ISFAACITQFYFYFFLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQ 173
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 174 GaVVQHFFCDSGPLLHLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTL 253
Cdd:cd15945  161 N-TINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGL 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 283135120 254 FYGSAIFLYVRPSQSGSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEALK 305
Cdd:cd15945  240 FYGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALK 291

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

29-304

1.39e-86

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 261.65 E-value: 1.39e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15428    3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLL 188
Cdd:cd15428   83 FGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHN-KINHFLCEMPALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 189 HLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQS 268
Cdd:cd15428  162 KLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 283135120 269 GSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15428  242 TSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

29-297

6.02e-86

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 259.45 E-value: 6.02e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15939    3 CFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLL 188
Cdd:cd15939   83 FGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPN-VIDHFFCDLFPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 189 HLACTNTtrleeadFVLAFLVI-------MSSLTITGASYGhIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFL 261
Cdd:cd15939  162 KLACTDT-------YVIGLLVVansglicLLSFLILLISYI-VILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFI 233

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 283135120 262 YVRPSQSGSVDTnwSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15939  234 YMRPVTTFPIDK--VVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

30-310

1.57e-85

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 259.28 E-value: 1.57e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15414    4 FLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQgAVVQHFFCDSGPLLH 189
Cdd:cd15414   84 VAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGP-NVINHFFCDIPPLLS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15414  163 LSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSS 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEALKEMFRK 310
Cdd:cd15414  243 SLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRR 283

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

30-307

4.10e-84

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 255.76 E-value: 4.10e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15406   13 FLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVF 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15406   93 AIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDN-VINHYFCDILPLLK 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVL-AFLVIMSSLTITGaSYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQS 268
Cdd:cd15406  172 LSCSSTYINELLLFIVgGFNVLATTLAILI-SYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLKPSSS 250

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 283135120 269 GSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEALKEM 307
Cdd:cd15406  251 SSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

30-297

6.88e-84

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 254.60 E-value: 6.88e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15430    4 FVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15430   84 GSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNN-VINHFTCEILAVLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15430  163 LACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKN 242

                        250       260
                 ....*....|....*....|....*...
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15430  243 AQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

30-304

7.05e-84

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 254.81 E-value: 7.05e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15234    4 FGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQgAVVQHFFCDSGPLLH 189
Cdd:cd15234   84 GGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTD-VEIPHFFCELAQVLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTrleeADFVLAFLV--IMSSLTITGA--SYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRP 265
Cdd:cd15234  163 LACSDTL----INNILIYLAtvIFGGIPLSGIifSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISS 238

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 283135120 266 SQSGSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15234  239 AVTHSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

30-297

1.39e-83

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 253.67 E-value: 1.39e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15226    4 FVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15226   84 GGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPN-VVDSFFCDLPLVIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIvLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15226  163 LACTDTYVLELMVVANSGLISLVCFLLLLISYIVI-LVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                        250       260
                 ....*....|....*....|....*...
gi 283135120 270 SVDTnwSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15226  242 PVDK--FLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

29-304

1.91e-83

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 253.50 E-value: 1.91e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15424    3 LFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGAvVQHFFCDSGPLL 188
Cdd:cd15424   83 LGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNH-INHFFCELPVVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 189 HLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQS 268
Cdd:cd15424  162 KLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSG 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 283135120 269 GSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15424  242 STPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

14-308

2.89e-83

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 253.94 E-value: 2.89e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  14 FVLAGFPNLNSTGAEVFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHT 93
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  94 ISFAACITQFYFYFFLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQ 173
Cdd:cd15944   81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 174 GaVVQHFFCDSGPLLHLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTL 253
Cdd:cd15944  161 N-IINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTL 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 283135120 254 FYGSAIFLYVRPSQSGSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEALKEMF 308
Cdd:cd15944  240 FYGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

29-304

7.18e-83

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 252.01 E-value: 7.18e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15432    3 LFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQgAVVQHFFCDSGPLL 188
Cdd:cd15432   83 LGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGR-RRVDHFFCEVPALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 189 HLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQS 268
Cdd:cd15432  162 KLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSN 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 283135120 269 GSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15432  242 SSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

30-304

1.31e-81

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 248.89 E-value: 1.31e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15228    4 FVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15228   84 GSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSN-VVDYFFCDIFPVLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15228  163 LACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSP 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 283135120 270 SVDTnwSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15228  243 VLVT--PVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

30-297

2.42e-81

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 247.74 E-value: 2.42e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15940    4 FMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15940   84 ACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPN-EIDSFFCDVPPVIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIpSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15940  163 LACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSF 241

                        250       260
                 ....*....|....*....|....*...
gi 283135120 270 SVDTnwSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15940  242 SEDK--VVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

27-304

2.56e-81

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 248.13 E-value: 2.56e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  27 AEVFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRR-HTISFAACITQFYF 105
Cdd:cd15916    1 SLLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 106 YFFLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGAVvQHFFCDSG 185
Cdd:cd15916   81 FHFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRI-DYFFCDIP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 186 PLLHLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRP 265
Cdd:cd15916  160 PLLKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRP 239

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 283135120 266 SQSGSVDTnwSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15916  240 GSKEALDG--VIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

30-304

9.39e-79

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 241.60 E-value: 9.39e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15236    4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKqGAVVQHFFCDSGPLLH 189
Cdd:cd15236   84 GCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCA-DNVIPHFFCDLVALLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15236  163 LSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNN 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15236  243 SSDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

29-297

1.87e-78

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 240.84 E-value: 1.87e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15946    3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGAvVQHFFCDSGPLL 188
Cdd:cd15946   83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNE-INHYFCEVPAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 189 HLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQS 268
Cdd:cd15946  162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSN 241

                        250       260
                 ....*....|....*....|....*....
gi 283135120 269 GSVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15946  242 YSPERDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

30-305

8.08e-78

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 239.24 E-value: 8.08e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15407    4 FIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15407   84 ATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSN-VINHFFCDIPPVLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15407  163 LSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSH 242

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEALK 305
Cdd:cd15407  243 SMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFK 278

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

27-304

1.70e-77

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 238.49 E-value: 1.70e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  27 AEVFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFY 106
Cdd:cd15942    1 APLFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 107 FFLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCkQGAVVQHFFCDSGP 186
Cdd:cd15942   81 HFLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYG-QKNEVDYIFCDIPA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 187 LLHLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPS 266
Cdd:cd15942  160 MLKLACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPG 239

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 283135120 267 QSGSVDTnwSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15942  240 SQDPLDG--VVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

30-304

2.43e-77

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 238.09 E-value: 2.43e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15405    4 FFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKqGAVVQHFFCDSGPLLH 189
Cdd:cd15405   84 VISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCD-SNIINHYMCDILPLLQ 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSG 269
Cdd:cd15405  163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVG 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15405  243 SVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

30-305

3.25e-77

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 237.76 E-value: 3.25e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15418    5 FVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15418   85 AYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDN-IIDHFFCDLPPLVK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEeadFVLAFLVIMSSLTITG---ASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPS 266
Cdd:cd15418  164 LACDDTRVYE---LILYFILGFNVIAPTAlilASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 283135120 267 QSGSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEALK 305
Cdd:cd15418  241 SSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALK 279

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

30-297

6.10e-77

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 236.85 E-value: 6.10e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15936    4 FLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFT 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLH 189
Cdd:cd15936   84 GGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPN-VLDNFYCDVPQVIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 LACTNTTRLEEADF-------VLAFLVIMSSLTitgasyghIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLY 262
Cdd:cd15936  163 LACTDTFLLELLMVsnsglvtLLIFFILLISYT--------VILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIY 234

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 283135120 263 VRPSQSGSVDTnwSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15936  235 ARPFQTFPMDK--AVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

29-304

1.92e-76

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 235.84 E-value: 1.92e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15233    3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLL 188
Cdd:cd15233   83 LAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPN-VINHFFCDLPPLF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 189 HLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQS 268
Cdd:cd15233  162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSV 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 283135120 269 GSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15233  242 YSSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

27-297

1.09e-73

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 228.22 E-value: 1.09e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  27 AEVFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFY 106
Cdd:cd15938    1 ALLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 107 FFLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGAvVQHFFCDSGP 186
Cdd:cd15938   81 HFVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQ-VNNFFCDVPP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 187 LLHLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIvlaVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPS 266
Cdd:cd15938  160 VIKLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPF 236

                        250       260       270
                 ....*....|....*....|....*....|.
gi 283135120 267 QSGSVDTNwsVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15938  237 STFPVDKH--VSVLYNVITPMLNPLIYTLRN 265

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

30-304

7.72e-71

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 221.26 E-value: 7.72e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQT-PMYFFLANLSCLEILITSVIIPKMLSNFLSRRH-TISFAACITQFYFYF 107
Cdd:cd15941    4 FLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSGrTISFEGCVVQLYAFH 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 108 FLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGAvVQHFFCDSGPL 187
Cdd:cd15941   84 FLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQ-IAYFFCDIPPV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 188 LHLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQ 267
Cdd:cd15941  163 LKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 283135120 268 SGSVDTnwSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15941  243 SQAGAG--APAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

29-304

8.29e-71

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 221.20 E-value: 8.29e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15433    3 LFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQgAVVQHFFCDSGPLL 188
Cdd:cd15433   83 LGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGH-RLLDHFFCEMPVFL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 189 HLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQS 268
Cdd:cd15433  162 KLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHR 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 283135120 269 GSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15433  242 YSQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

29-297

5.90e-68

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 213.83 E-value: 5.90e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15937    3 LFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLL 188
Cdd:cd15937   83 LGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPN-VLDNFFCDITQVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 189 HLACTNTTRLEEADFVLAFLVIMSSLTITGASYGhIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQS 268
Cdd:cd15937  162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYA-FLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRS 240

                        250       260
                 ....*....|....*....|....*....
gi 283135120 269 GSVDTnwSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15937  241 FPMDK--VVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

29-297

7.99e-68

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 213.47 E-value: 7.99e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGAD-HRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYF 107
Cdd:cd15935    3 LFVLVLACYAAILLGNLLIVVTVHADpHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLH 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 108 FLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPL 187
Cdd:cd15935   83 FLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPN-ELDNFYCDVPQV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 188 LHLACTNTTRLEEADFVLAFLVIMSSLTITGASYGhIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQ 267
Cdd:cd15935  162 IKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYG-IILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 283135120 268 SGSVDTnwSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd15935  241 SSSVDK--VASVFYTLITPALNPLIYTLRN 268

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

33-304

3.27e-60

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 194.05 E-value: 3.27e-60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  33 FLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGAS 112
Cdd:cd15223    7 FLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 113 EFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWM-GGLLPVLGPTVAvALLPFCKQGaVVQHFFCDSGPLLHLA 191
Cdd:cd15223   87 ESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIrSGLLVLPIVVLA-SQLSYCSSN-VIEHCYCDHMALVSLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 192 CTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYV--RPSQSG 269
Cdd:cd15223  165 CGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyRFGKTI 244

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15223  245 PPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

33-300

1.48e-55

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 182.10 E-value: 1.48e-55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  33 FLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGAS 112
Cdd:cd15917    7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 113 EFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCkQGAVVQHFFCDSGPLLHLAC 192
Cdd:cd15917   87 ESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYC-GSNVISHSYCEHMAVVKLAC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 193 TNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYV--RPSQSGS 270
Cdd:cd15917  166 GDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLthRFGHHVP 245

                        250       260       270
                 ....*....|....*....|....*....|
gi 283135120 271 VDTNWSVTVITTFVTPLLNPFIYALRNDQV 300
Cdd:cd15917  246 PHVHILLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

33-300

4.08e-53

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 175.56 E-value: 4.08e-53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  33 FLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGAS 112
Cdd:cd15221    7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 113 EFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLHLAC 192
Cdd:cd15221   87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHN-VIPHTYCEHMGIARLAC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 193 TNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSGSVD 272
Cdd:cd15221  166 ADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFGRHIP 245

                        250       260       270
                 ....*....|....*....|....*....|
gi 283135120 273 TNWSVTVITTFVT--PLLNPFIYALRNDQV 300
Cdd:cd15221  246 RHVHILLANLYVLvpPMLNPIVYGVKTKQI 275

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

33-300

1.30e-52

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 174.52 E-value: 1.30e-52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  33 FLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGAS 112
Cdd:cd15950    7 FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 113 EFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQgAVVQHFFCDSGPLLHLAC 192
Cdd:cd15950   87 ESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGS-RVVPHSYCEHMAVVKLAC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 193 TNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFY--GSAIFLYVRPSQSGS 270
Cdd:cd15950  166 ADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYipGLLSIYTQRFGQGVP 245

                        250       260       270
                 ....*....|....*....|....*....|
gi 283135120 271 VDTNWSVTVITTFVTPLLNPFIYALRNDQV 300
Cdd:cd15950  246 PHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

33-300

5.27e-52

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 172.83 E-value: 5.27e-52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  33 FLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGAS 112
Cdd:cd15953    7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 113 EFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQgAVVQHFFCDSGPLLHLAC 192
Cdd:cd15953   87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCAN-RIIPHTYCEHMAVVKLAC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 193 TNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYV--RPSQSGS 270
Cdd:cd15953  166 GDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLthRFGQGIA 245

                        250       260       270
                 ....*....|....*....|....*....|
gi 283135120 271 VDTNWSVTVITTFVTPLLNPFIYALRNDQV 300
Cdd:cd15953  246 PHIHIILANLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

33-300

4.37e-48

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 162.67 E-value: 4.37e-48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  33 FLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGAS 112
Cdd:cd15222    7 FCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 113 EFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLHLAC 192
Cdd:cd15222   87 ESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSN-VLSHSYCLHQDVMKLAC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 193 TNTTR-----LeeadFVLAFLVIMSSLTItGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYV--RP 265
Cdd:cd15222  166 SDTRVnsiygL----FVVLSTMGLDSLLI-LLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMvhRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 283135120 266 SQSGSVDTNWSVTVITTFVTPLLNPFIYALRNDQV 300
Cdd:cd15222  241 GKHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

33-300

3.98e-47

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 160.20 E-value: 3.98e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  33 FLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGAS 112
Cdd:cd15951    7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 113 EFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLHLAC 192
Cdd:cd15951   87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTN-IIPHTYCEHMAVVKLAC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 193 TNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIF--LYVRPSQSGS 270
Cdd:cd15951  166 ADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFsfLTHRFGHNVP 245

                        250       260       270
                 ....*....|....*....|....*....|
gi 283135120 271 VDTNWSVTVITTFVTPLLNPFIYALRNDQV 300
Cdd:cd15951  246 PHVHILIANVYLLVPPMLNPIIYGVRTKQI 275

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

32-300

3.75e-46

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 157.72 E-value: 3.75e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGA 111
Cdd:cd15956    6 PFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 112 SEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCkQGAVVQHFFCDSGPLLHLA 191
Cdd:cd15956   86 MESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFC-ASHTIAHTYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 192 CTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSGSV 271
Cdd:cd15956  165 CGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGHSV 244

                        250       260       270
                 ....*....|....*....|....*....|.
gi 283135120 272 DTNWSVTV--ITTFVTPLLNPFIYALRNDQV 300
Cdd:cd15956  245 PSAAHVLLsnLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

33-300

1.29e-45

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 156.39 E-value: 1.29e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  33 FLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGAS 112
Cdd:cd15952    7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 113 EFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQgAVVQHFFCDSGPLLHLAC 192
Cdd:cd15952   87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGH-NIIPHTYCEHMGIAKLAC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 193 TNT-TRLEEADFVLAFLVImsSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYV--RPSQSG 269
Cdd:cd15952  166 ASIrINIIYGLFAISVLVL--DVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLthRFGHNI 243

                        250       260       270
                 ....*....|....*....|....*....|.
gi 283135120 270 SVDTNWSVTVITTFVTPLLNPFIYALRNDQV 300
Cdd:cd15952  244 PRYIHILLANLYVVLPPMLNPVIYGVRTKQI 274

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

33-308

5.67e-41

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 144.18 E-value: 5.67e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120   33 FLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGAS 112
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  113 EFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGaVVQHFFCDSGPLLHLAC 192
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHH-VLSHSYCLHMGLARLSC 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  193 TNTTrleeADFVLAFLVIMSSLTITG----ASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYV--RPS 266
Cdd:pfam13853 160 ADIK----VNNIYGLFVVTSTFGIDSllivLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFG 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 283135120  267 QSGSVDTNWSVTVITTFVTPLLNPFIYALRNDQVKEALKEMF 308
Cdd:pfam13853 236 HNVPPLLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

33-301

5.18e-38

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 136.57 E-value: 5.18e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  33 FLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGAS 112
Cdd:cd15948    8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 113 EFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKqGAVVQHFFCDSGPLLHLAC 192
Cdd:cd15948   88 ESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCR-SHVIAHCYCEHMAVVKLAC 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 193 TNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYV--RPSQSGS 270
Cdd:cd15948  167 GDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTmhRFARHVA 246

                        250       260       270
                 ....*....|....*....|....*....|.
gi 283135120 271 VDTNWSVTVITTFVTPLLNPFIYALRNDQVK 301
Cdd:cd15948  247 PHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

33-300

2.91e-36

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 131.87 E-value: 2.91e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  33 FLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGAS 112
Cdd:cd15954    7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 113 EFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKqGAVVQHFFCDSGPLLHLAC 192
Cdd:cd15954   87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCR-GNFIPHTYCDHMSVVKLAC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 193 TNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYVRPSQSGSVD 272
Cdd:cd15954  166 ANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRFGGHHI 245

                        250       260       270
                 ....*....|....*....|....*....|.
gi 283135120 273 TNWSVTVITT---FVTPLLNPFIYALRNDQV 300
Cdd:cd15954  246 TPHIHIIMANlylLLPPMMNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

43-293

4.83e-36

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 130.88 E-value: 4.83e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120   43 GNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRH-TISFAACITQFYFYFFLGASEFLLLAVMS 121
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  122 VDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLpvlgptvaVALLPFC----KQGAVVQHFFCDSGPLLHLACTNTTR 197
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALL--------LSLPPLLfgwtLTVPEGNVTVCFIDFPEDLSKPVSYT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  198 LeeADFVLAFLVimsSLTITGASYGHIVLAVLRIPSASGR-------QKAFSTCTSHLMVVTLFYGSAIFLYVRPS---- 266
Cdd:pfam00001 153 L--LISVLGFLL---PLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDSlald 227

                         250       260
                  ....*....|....*....|....*....
gi 283135120  267 --QSGSVDTNWSVTVITTFVTPLLNPFIY 293
Cdd:pfam00001 228 ceLSRLLDKALSVTLWLAYVNSCLNPIIY 256

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

12-301

9.02e-35

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 128.36 E-value: 9.02e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  12 TEFVLAGFPNLNSTGAEVFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRR 91
Cdd:cd15949    2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  92 HTISFAACITQFYFYFFLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFC 171
Cdd:cd15949   82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 172 KQGaVVQHFFCDSGPLLHLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVV 251
Cdd:cd15949  162 RTN-IIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAI 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 283135120 252 TLFYG--SAIFLYVRPSQSGSVDTNWSVTVITTFVTPLLNPFIYALRNDQVK 301
Cdd:cd15949  241 LAFYVpiAVSSLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

33-300

3.06e-32

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 121.03 E-value: 3.06e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  33 FLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGAS 112
Cdd:cd15955    7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 113 EFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGAVVQHFFCDSGPLLHLAC 192
Cdd:cd15955   87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 193 TNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFYGSAIFLYV--RPSQSGS 270
Cdd:cd15955  167 DDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFahRFGHHVA 246

                        250       260       270
                 ....*....|....*....|....*....|
gi 283135120 271 VDTNWSVTVITTFVTPLLNPFIYALRNDQV 300
Cdd:cd15955  247 PYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

30-297

2.63e-24

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 99.67 E-value: 2.63e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd00637    2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLpvlgptvaVALLPFCKQGAVVQHFFCDSGPllh 189
Cdd:cd00637   82 LLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLL--------LALPPLLGWGVYDYGGYCCCCL--- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 190 lACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAV----LRIPSASGRQKAFSTCTSH-------LMVVTLFYGS- 257
Cdd:cd00637  151 -CWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLrrhrRRIRSSSSNSSRRRRRRRErkvtktlLIVVVVFLLCw 229

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 283135120 258 ------AIFLYVRPSQSGSVDTNWSVTVITTFVTPLLNPFIYALRN 297
Cdd:cd00637  230 lpyfilLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

32-304

1.28e-15

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 75.29 E-value: 1.28e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGA 111
Cdd:cd14967    5 FLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 112 SEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGAVVQHFFCDSGPLLHLA 191
Cdd:cd14967   85 ASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNKIYVLVSS 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 192 CTNttrleeadFVLAFLvIMSSLtitgasYGHIVLAVLRipsasgRQKAFSTcTSHLMVVTL-----FYGSAIFLYVRPS 266
Cdd:cd14967  165 VIS--------FFIPLL-IMIVL------YARIFRVARR------ELKAAKT-LAIIVGAFLlcwlpFFIIYLVSAFCPP 222

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 283135120 267 QSGSvDTNWSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd14967  223 DCVP-PILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

34-297

9.26e-11

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 61.87 E-value: 9.26e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  34 LFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLS---NFLSRRHTISFAACitqfyFYFFLG 110
Cdd:cd15069    8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITislGFCTDFHSCLFLAC-----FVLVLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 111 ASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMG----GLLPVLGPTVAVALLPFCKQGAvvQHFFCDSGP 186
Cdd:cd15069   83 QSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLafgiGLTPFLGWNKAMSATNNSTNPA--DHGTNHSCC 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 187 LLHLACTNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLRI--------PSASGRQKAFSTCTSHLMVVTLFYGSA 258
Cdd:cd15069  161 LISCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQlqrtelmdHSRTTLQREIHAAKSLAIIVGIFALCW 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 283135120 259 IFLYV-------RPSQsGSVDTNWS--VTVITTFVTPLLNPFIYALRN 297
Cdd:cd15069  241 LPVHIlncitlfQPEF-SKSKPKWAmnVAILLSHANSVVNPIVYAYRN 287

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

28-160

1.76e-10

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 60.68 E-value: 1.76e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  28 EVFSVFLFVY-LLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFY 106
Cdd:cd14969    1 YVLAVYLSLIgVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 283135120 107 FFLGASEFLLLAVMSVDRYLAICRPLhYPLLMNGAVCFRVALACWMGGLL----PVLG 160
Cdd:cd14969   81 TFLGLVSISTLAALAFERYLVIVRPL-KAFRLSKRRALILIAFIWLYGLFwalpPLFG 137

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

38-304

3.79e-10

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 59.96 E-value: 3.79e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  38 LLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPkmLSNFLSRRHTISFAACITQFYFYFFLG-ASEFLL 116
Cdd:cd14968   12 VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCLFMACLVLVLTqSSIFSL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 117 LAVmSVDRYLAICRPLHYPLLMNGAVCFRVALACWMG----GLLPVLGPTVAVALLPFCKQGAVVQHFfcdsgpllhlac 192
Cdd:cd14968   90 LAI-AIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLsflvGLTPMFGWNNGAPLESGCGEGGIQCLF------------ 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 193 TNTTRLEEADFVLAFLVIMSSLTITGASYGHIVLAVLR----IPSASG-------RQKAFSTCTSHLMVVTLFYGSAIFL 261
Cdd:cd14968  157 EEVIPMDYMVYFNFFACVLVPLLIMLVIYLRIFRVIRKqlrqIESLLRsrrsrstLQKEVKAAKSLAIILFLFALCWLPL 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 283135120 262 YVRPSQS---GSVDTNWSVTVITTFVTPL---LNPFIYALRNDQVKEAL 304
Cdd:cd14968  237 HIINCITlfcPECKVPKILTYIAILLSHAnsaVNPIVYAYRIRKFRQTF 285

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

28-156

4.43e-09

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 56.52 E-value: 4.43e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  28 EVFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYF 107
Cdd:cd15001    1 PVIIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 283135120 108 FLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLL 156
Cdd:cd15001   81 LSFICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAI 129

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

29-160

1.05e-08

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 55.35 E-value: 1.05e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15329    3 IGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLL----PVLG 160
Cdd:cd15329   83 LCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALisipPLFG 138

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

39-161

1.44e-08

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 55.07 E-value: 1.44e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  39 LTLTGNTLIVVLVGADHRLQ-TPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGASEFLLL 117
Cdd:cd15104   12 LIITGNLLVIVALLKLIRKKdTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSCAASVLSL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 283135120 118 AVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGP 161
Cdd:cd15104   92 AAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLP 135

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

30-163

2.19e-08

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 54.42 E-value: 2.19e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15063    4 LLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWM 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTV 163
Cdd:cd15063   84 CTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLV 137

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

33-304

3.16e-08

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 53.99 E-value: 3.16e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  33 FLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGAS 112
Cdd:cd15012    6 YTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 113 EFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMggllpvlgpTVAVALLPFCKQGAVVQHFFCDSGPLLHLAC 192
Cdd:cd15012   86 SIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWL---------TSAVYNTPYFVFSQTVEILVTQDGQEEEICV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 193 T-----NTTRLEEADFVLAFLVIMSSLTITgasYGHIVLAVLRIPSASGRQKAFSTCTSHLMVVTLFY--GSAIFLYVRP 265
Cdd:cd15012  157 LdremfNSKLYDTINFIVWYLIPLLIMTVL---YSKISIVLWKSSSIEARRKVVRLLVAVVVSFALCNlpYHARKMWQYW 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 283135120 266 SQSGSVDTNWS-----VTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15012  234 SEPYRCDSNWNalltpLTFLVLYFNSAVNPLLYAFLSKRFRQSM 277

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

29-152

6.67e-08

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 52.99 E-value: 6.67e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLF-VYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAAC-ITQFYFY 106
Cdd:cd14993    2 VLIVLYVvVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCkAVPYLQG 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 283135120 107 FFLGASeFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWM 152
Cdd:cd14993   82 VSVSAS-VLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWV 126

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

34-160

8.06e-08

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 53.02 E-value: 8.06e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  34 LFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPkmLSNFLSRRHTISFAACITQFYFYFFLGASE 113
Cdd:cd15068    8 LAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP--FAITISTGFCAACHGCLFIACFVLVLTQSS 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 283135120 114 FLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMG----GLLPVLG 160
Cdd:cd15068   86 IFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLsfaiGLTPMLG 136

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

35-151

1.23e-07

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 52.46 E-value: 1.23e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  35 FVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMlsnFLSRRH----TISFAACITQFYFYFFLG 110
Cdd:cd15005    9 LILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFV---MASVRHgsgwIYGALSCKVIAFLAVLFC 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 283135120 111 ASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACW 151
Cdd:cd15005   86 FHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAW 126

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

32-134

1.36e-07

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 51.85 E-value: 1.36e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSV-IIPKMLSNFLSRRHTISFAACITQFYFYFFLG 110
Cdd:cd15196    6 VLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFnVLPQLIWDITYRFYGGDLLCRLVKYLQVVGMY 85

                         90       100
                 ....*....|....*....|....
gi 283135120 111 ASEFLLLAvMSVDRYLAICRPLHY 134
Cdd:cd15196   86 ASSYVLVA-TAIDRYIAICHPLSS 108

7tmA_DmOct-betaAR-like

cd15066

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...

32-156

1.40e-07

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.

Pssm-ID: 320194 [Multi-domain] Cd Length: 265 Bit Score: 51.99 E-value: 1.40e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGA 111
Cdd:cd15066    5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFST 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 283135120 112 SEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLL 156
Cdd:cd15066   85 ASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPAL 129

7tmA_PR4-like

cd15392

neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...

29-159

4.61e-07

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.

Pssm-ID: 320514 [Multi-domain] Cd Length: 287 Bit Score: 50.44 E-value: 4.61e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIP-KMLSNFLSRRHTISFAACITQFYFY- 106
Cdd:cd15392    3 IILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPfSFIALLILQYWPFGEFMCPVVNYLQa 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 283135120 107 --FFLGAsefLLLAVMSVDRYLAICRPLHYPLLMNGAvcFRVALACWMGGLLPVL 159
Cdd:cd15392   83 vsVFVSA---FTLVAISIDRYVAIMWPLRPRMTKRQA--LLLIAVIWIFALATAL 132

7tmA_alpha2B_AR

cd15321

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

27-134

4.75e-07

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320444 [Multi-domain] Cd Length: 268 Bit Score: 50.31 E-value: 4.75e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  27 AEVFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFY 106
Cdd:cd15321    7 AAIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALD 86

                         90       100
                 ....*....|....*....|....*...
gi 283135120 107 FFLGASEFLLLAVMSVDRYLAICRPLHY 134
Cdd:cd15321   87 VLFCTSSIVHLCAISLDRYWSVSRAIEY 114

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

29-152

4.91e-07

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 50.52 E-value: 4.91e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPkmLSNFLSRRHTISFAACITQFYFY-- 106
Cdd:cd15317    3 IYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMP--FSMIRTVETCWYFGDLFCKFHTGld 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 283135120 107 FFLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWM 152
Cdd:cd15317   81 LLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWL 126

7tmA_alpha2_AR

cd15059

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...

31-161

4.96e-07

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320187 [Multi-domain] Cd Length: 261 Bit Score: 50.03 E-value: 4.96e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  31 SVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLG 110
Cdd:cd15059    5 SIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFC 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 283135120 111 ASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGP 161
Cdd:cd15059   85 TASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPP 135

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

34-134

5.59e-07

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 50.00 E-value: 5.59e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  34 LFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIP-KMLSNFLSRRHTISFAACITQFYFYFFLGAS 112
Cdd:cd15052    8 LLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLDVLFCTA 87

                         90       100
                 ....*....|....*....|..
gi 283135120 113 EFLLLAVMSVDRYLAICRPLHY 134
Cdd:cd15052   88 SIMHLCTISLDRYMAIRYPLRT 109

7tmA_CCK_R

cd15206

cholecystokinin receptors, member of the class A family of seven-transmembrane G ...

36-175

5.63e-07

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320334 [Multi-domain] Cd Length: 269 Bit Score: 50.08 E-value: 5.63e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  36 VYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFY-FFLGASEF 114
Cdd:cd15206   10 IFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQaVSVSVSTF 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 283135120 115 LLLAVmSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQGA 175
Cdd:cd15206   90 TLVAI-SLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPGG 149

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

31-161

9.47e-07

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 49.64 E-value: 9.47e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  31 SVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACitQFYFYF--F 108
Cdd:cd15083    5 IFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGC--DMYGFSggL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGP 161
Cdd:cd15083   83 FGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPP 135

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

32-160

1.23e-06

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 49.21 E-value: 1.23e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGA 111
Cdd:cd14972    4 VAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLA 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 283135120 112 SEFLLLAVmSVDRYLAICRPLHYPLLMNGAVCFRVALACWMG----GLLPVLG 160
Cdd:cd14972   84 SAYSLLAI-AVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWsvllALLPVLG 135

7tmA_5-HT6

cd15054

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...

35-151

1.56e-06

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320182 [Multi-domain] Cd Length: 267 Bit Score: 48.65 E-value: 1.56e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  35 FVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGASEF 114
Cdd:cd15054    9 LIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASI 88

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 283135120 115 LLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACW 151
Cdd:cd15054   89 LNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAW 125

7tmA_OXR

cd15208

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

33-132

1.88e-06

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.

Pssm-ID: 320336 [Multi-domain] Cd Length: 303 Bit Score: 48.92 E-value: 1.88e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  33 FLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGAS 112
Cdd:cd15208    7 YILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTVSVSV 86

                         90       100
                 ....*....|....*....|
gi 283135120 113 EFLLLAVMSVDRYLAICRPL 132
Cdd:cd15208   87 SVLTLSCIALDRWYAICHPL 106

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

31-310

2.58e-06

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 48.06 E-value: 2.58e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  31 SVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSvIIPKMLSNFLSRRHTISFAACITQFYFYFFLG 110
Cdd:cd14970    5 AVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLL-GLPFLATSYLLGYWPFGEVMCKIVLSVDAYNM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 111 ASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLgptvavallPFCKQGAVVQHFFCDSGPLLHL 190
Cdd:cd14970   84 FTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGL---------PVIIFARTLQEEGGTISCNLQW 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 191 ACTNTTRLEEA---DFVLAFLVimsSLTITGASYGHIVL---AVLRIPSASGRQKAFSTCTSHLMVVTL----------F 254
Cdd:cd14970  155 PDPPDYWGRVFtiyTFVLGFAV---PLLVITVCYSLIIRrlrSSRNLSTSGAREKRRARRKVTRLVLVVvavfvvcwlpF 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 283135120 255 YGSAIF-LYVRPSQSGSVDTNWSVTVITTFVTPLLNPFIYALrndqvkeaLKEMFRK 310
Cdd:cd14970  232 HVFQIVrLLIDPPETLTVVGVFLFCIALSYANSCLNPILYAF--------LDENFRK 280

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

32-133

2.64e-06

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 48.06 E-value: 2.64e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRR-----HTISFAACITQFYFY 106
Cdd:cd14997    6 VYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREpwllgEFMCKLVPFVELTVA 85

                         90       100
                 ....*....|....*....|....*..
gi 283135120 107 FflgASEFLLLAVmSVDRYLAICRPLH 133
Cdd:cd14997   86 H---ASVLTILAI-SFERYYAICHPLQ 108

7tmA_NTSR1

cd15355

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...

29-156

2.75e-06

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.

Pssm-ID: 320477 [Multi-domain] Cd Length: 310 Bit Score: 48.30 E-value: 2.75e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTL---IVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYf 105
Cdd:cd15355    3 VTAIYLALFVVGTVGNSItlyTLARKKSLQHLQSTVHYHLASLALSDLLILLLAMPVELYNFIWVHHPWAFGDAACRGY- 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 283135120 106 YFFLGASEF---LLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLL 156
Cdd:cd15355   82 YFLRDACTYataLNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASAL 135

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

34-151

3.00e-06

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 48.00 E-value: 3.00e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  34 LFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIP-KMLSNFLSRRHTISFAACITQFYFYFFLGAS 112
Cdd:cd15304    8 VIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLDVLFSTA 87

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 283135120 113 EFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACW 151
Cdd:cd15304   88 SIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVW 126

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

32-156

3.20e-06

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 48.01 E-value: 3.20e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADhRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFY----- 106
Cdd:cd14978    6 VLPVICIFGIIGNILNLVVLTRK-SMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFLPYiypla 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 283135120 107 -FFLGASEFLLLAvMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLL 156
Cdd:cd14978   85 nTFQTASVWLTVA-LTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLL 134

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

38-161

4.03e-06

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 47.58 E-value: 4.03e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  38 LLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGASEFLLL 117
Cdd:cd15325   12 LFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 283135120 118 AVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGP 161
Cdd:cd15325   92 CIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGP 135

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

34-160

5.22e-06

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 47.27 E-value: 5.22e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  34 LFVYLLTLTGN-TLIVVLVGADHRLQtPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGAS 112
Cdd:cd15074    8 TVIGILSTLGNgTVLFVLYRRRSKLK-PAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCC 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 283135120 113 EFLLLAVMSVDRYLAICRPLHYPLLMNGAVCfRVALACWMGGLL----PVLG 160
Cdd:cd15074   87 SINTLTAISIYRYLKICHPPYGPKLSRRHVC-IVIVAIWLYALFwavaPLVG 137

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

32-216

5.62e-06

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 47.35 E-value: 5.62e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLsrrHTISFAACITQFYFYFFLGA 111
Cdd:cd14979    6 IYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFW---WQYPWAFGDGGCKLYYFLFE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 112 S----EFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVallpfckqGAVVQHFFCDSGPL 187
Cdd:cd14979   83 ActyaTVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLM--------GIQYLNGPLPGPVP 154

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 283135120 188 LHLACTNTTRLE------EADFVLAFLVIMSSLTI 216
Cdd:cd14979  155 DSAVCTLVVDRStfkyvfQVSTFIFFVLPMFVISI 189

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

29-132

6.29e-06

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 47.02 E-value: 6.29e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACitqfYFYFF 108
Cdd:cd15336    3 VGSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGC----ELYAF 78

                         90       100
                 ....*....|....*....|....*...
gi 283135120 109 LGA----SEFLLLAVMSVDRYLAICRPL 132
Cdd:cd15336   79 CGAlfgiTSMITLLAISLDRYLVITKPL 106

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

35-134

6.43e-06

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 47.04 E-value: 6.43e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  35 FVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGASEF 114
Cdd:cd15050    9 TISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASI 88

                         90       100
                 ....*....|....*....|
gi 283135120 115 LLLAVMSVDRYLAICRPLHY 134
Cdd:cd15050   89 FSLFILCIDRYRSVQQPLKY 108

7tmA_CCK-AR

cd15978

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...

32-172

6.98e-06

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320644 [Multi-domain] Cd Length: 278 Bit Score: 46.79 E-value: 6.98e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGA 111
Cdd:cd15978    6 LYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVS 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 283135120 112 SEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCK 172
Cdd:cd15978   86 VSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTR 146

7tmA_alpha2C_AR

cd15323

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...

35-136

7.41e-06

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320446 [Multi-domain] Cd Length: 261 Bit Score: 46.85 E-value: 7.41e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  35 FVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGASEF 114
Cdd:cd15323    9 FLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSI 88

                         90       100
                 ....*....|....*....|..
gi 283135120 115 LLLAVMSVDRYLAICRPLHYPL 136
Cdd:cd15323   89 VHLCAISLDRYWSVTQAVEYNL 110

7tmA_TACR-like

cd15202

tachykinin receptors and related receptors, member of the class A family of ...

33-132

8.85e-06

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320330 [Multi-domain] Cd Length: 288 Bit Score: 46.73 E-value: 8.85e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  33 FLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAAC-ITQFYFYFFLGA 111
Cdd:cd15202    7 YSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMChFSNFAQYCSVHV 86

                         90       100
                 ....*....|....*....|.
gi 283135120 112 SEFLLLAVmSVDRYLAICRPL 132
Cdd:cd15202   87 SAYTLTAI-AVDRYQAIMHPL 106

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

32-152

9.05e-06

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 46.47 E-value: 9.05e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPkmLSNFLSRRHTISFAACITQFY--FYFFL 109
Cdd:cd15314    6 FLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMP--PSMVRSVETCWYFGDLFCKIHssFDITL 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWM 152
Cdd:cd15314   84 CTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWS 126

7tmA_GPR161

cd15214

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...

34-170

9.63e-06

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320342 [Multi-domain] Cd Length: 261 Bit Score: 46.47 E-value: 9.63e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  34 LFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGASE 113
Cdd:cd15214    7 IIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSAS 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 283135120 114 FLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPF 170
Cdd:cd15214   87 MLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSLEF 143

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

32-134

1.06e-05

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 46.48 E-value: 1.06e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGA 111
Cdd:cd15307    6 LALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCT 85

                         90       100
                 ....*....|....*....|...
gi 283135120 112 SEFLLLAVMSVDRYLAICRPLHY 134
Cdd:cd15307   86 ASIMHLCTISVDRYLSLRYPMRF 108

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

31-132

1.27e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 46.35 E-value: 1.27e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  31 SVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSV-IIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15387    5 TVLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFqVLPQLIWDITFRFYGPDFLCRLVKYLQVVGM 84

                         90       100
                 ....*....|....*....|...
gi 283135120 110 GASEFLLLaVMSVDRYLAICRPL 132
Cdd:cd15387   85 FASTYMLL-LMSIDRCLAICQPL 106

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

36-139

1.81e-05

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 45.91 E-value: 1.81e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  36 VYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGASEFL 115
Cdd:cd15058   10 IILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIE 89

                         90       100
                 ....*....|....*....|....
gi 283135120 116 LLAVMSVDRYLAICRPLHYPLLMN 139
Cdd:cd15058   90 TLCVIAVDRYIAITRPLRYQVLLT 113

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

29-156

1.84e-05

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 45.80 E-value: 1.84e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFvylLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15065    5 FLSLIIV---LAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVM 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLL 156
Cdd:cd15065   82 CSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSAL 129

7tmA_GHSR-like

cd15928

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...

27-157

1.90e-05

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.

Pssm-ID: 320594 [Multi-domain] Cd Length: 288 Bit Score: 45.56 E-value: 1.90e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  27 AEVFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFY 106
Cdd:cd15928    1 AAVTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFS 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 283135120 107 FFLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLP 157
Cdd:cd15928   81 ETCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVS 131

7tmA_Histamine_H2R

cd15051

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...

38-138

2.03e-05

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320179 [Multi-domain] Cd Length: 287 Bit Score: 45.40 E-value: 2.03e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  38 LLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGASEFLLL 117
Cdd:cd15051   12 LLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDVMLCTASILNL 91

                         90       100
                 ....*....|....*....|.
gi 283135120 118 AVMSVDRYLAICRPLHYPLLM 138
Cdd:cd15051   92 FAISLDRYLAITAPLRYPSRV 112

7tmA_mAChR_M1

cd17790

muscarinic acetylcholine receptor subtype M1, member of the class A family of ...

38-134

2.04e-05

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341356 [Multi-domain] Cd Length: 262 Bit Score: 45.34 E-value: 2.04e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  38 LLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGASEFLLL 117
Cdd:cd17790   12 LVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMNL 91

                         90
                 ....*....|....*..
gi 283135120 118 AVMSVDRYLAICRPLHY 134
Cdd:cd17790   92 LIISFDRYFSITRPLTY 108

7tmA_mAChR_DM1-like

cd15301

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...

32-134

2.05e-05

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320428 [Multi-domain] Cd Length: 270 Bit Score: 45.20 E-value: 2.05e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGA 111
Cdd:cd15301    6 VAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASN 85

                         90       100
                 ....*....|....*....|...
gi 283135120 112 SEFLLLAVMSVDRYLAICRPLHY 134
Cdd:cd15301   86 ASVLNLLIISFDRYFSVTRPLTY 108

7tmA_alpha1_AR

cd15062

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...

38-161

2.09e-05

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320190 [Multi-domain] Cd Length: 261 Bit Score: 45.17 E-value: 2.09e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  38 LLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGASEFLLL 117
Cdd:cd15062   12 LFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 283135120 118 AVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGP 161
Cdd:cd15062   92 CVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGP 135

7tmA_GPR19

cd15008

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...

32-134

2.14e-05

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320137 [Multi-domain] Cd Length: 275 Bit Score: 45.21 E-value: 2.14e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGA 111
Cdd:cd15008    5 VFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPG 84

                         90       100
                 ....*....|....*....|...
gi 283135120 112 SEFLLLAVMSVDRYLAICRPLHY 134
Cdd:cd15008   85 VQIYVLLSICVDRFYTIVYPLSF 107

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

30-293

2.23e-05

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 45.33 E-value: 2.23e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTL-IVVLVGaDHRLQTPMYFFLANLSCLEILITsVIIPKMLSNFLSRRHTI-SFAACITQFYFYF 107
Cdd:cd14982    4 PIVYSLIFILGLLGNILaLWVFLR-KMKKRSPTTIYMINLALADLLFV-LTLPFRIYYYLNGGWWPfGDFLCRLTGLLFY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 108 FLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWM---GGLLPVLgptvaVALLPFCKQGAVVQHFFCDS 184
Cdd:cd14982   82 INMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWIlvlVASVPLL-----LLRSTIAKENNSTTCFEFLS 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 185 GPLLHLACTNTTRLeeadfVLAFLVImssLTITGASYGHIVLAVLRIPSASG----RQKAFSTCTSHLMVVTLF---YGS 257
Cdd:cd14982  157 EWLASAAPIVLIAL-----VVGFLIP---LLIILVCYSLIIRALRRRSKQSQksvrKRKALRMILIVLAVFLVCflpYHV 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 283135120 258 AIFLYVRPSQSGSVDTNWSVTV-----ITTFVTPL---LNPFIY 293
Cdd:cd14982  229 TRILYLLVRLSFIADCSARNSLykayrITLCLASLnscLDPLIY 272

7tmA_5-HT4

cd15056

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...

29-151

2.43e-05

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320184 [Multi-domain] Cd Length: 294 Bit Score: 45.17 E-value: 2.43e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFL-FVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYF 107
Cdd:cd15056    2 VLSTFLsLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDV 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 283135120 108 FLGASEFLLLAVMSVDRYLAICR-PLHYPllMNGAVCFRVALACW 151
Cdd:cd15056   82 LLTTASIMHLCCIALDRYYAICCqPLVYK--MTPLRVAVMLGGCW 124

7tmA_alpha2A_AR

cd15322

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

38-136

2.45e-05

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320445 [Multi-domain] Cd Length: 259 Bit Score: 44.94 E-value: 2.45e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  38 LLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGASEFLLL 117
Cdd:cd15322   12 LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHL 91

                         90
                 ....*....|....*....
gi 283135120 118 AVMSVDRYLAICRPLHYPL 136
Cdd:cd15322   92 CAISLDRYWSITQAIEYNL 110

7tmA_GPR83

cd15389

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...

35-132

2.52e-05

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.

Pssm-ID: 320511 [Multi-domain] Cd Length: 285 Bit Score: 45.02 E-value: 2.52e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  35 FVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAAC-ITQFYFYFFLGASE 113
Cdd:cd15389    9 IIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMChLSRFAQYCSVYVST 88

                         90
                 ....*....|....*....
gi 283135120 114 FLLLAVmSVDRYLAICRPL 132
Cdd:cd15389   89 LTLTAI-ALDRHRVILHPL 106

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

29-163

2.96e-05

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 45.11 E-value: 2.96e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVY-LLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACitQFYFY- 106
Cdd:cd15073    2 IVAAYLIVAgIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGC--QWYAFl 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 283135120 107 -FFLGASEFLLLAVMSVDRYLAICRPLHYPlLMNGAVCFRVALACWMGGLLPVLGPTV 163
Cdd:cd15073   80 nIFFGMASIGLLTVVAVDRYLTICRPDLGR-KMTTNTYTVMILLAWTNAFFWAAMPLV 136

7tmA_mAChR_M3

cd15299

muscarinic acetylcholine receptor subtype M3, member of the class A family of ...

29-134

2.98e-05

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320426 [Multi-domain] Cd Length: 274 Bit Score: 44.94 E-value: 2.98e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFL--FVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFY 106
Cdd:cd15299    4 VLIAFLtgILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSID 83

                         90       100
                 ....*....|....*....|....*...
gi 283135120 107 FFLGASEFLLLAVMSVDRYLAICRPLHY 134
Cdd:cd15299   84 YVASNASVMNLLVISFDRYFSITRPLTY 111

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

32-152

3.19e-05

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 44.65 E-value: 3.19e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVY-LLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPkMLSNFLSRRHTISFAA--CITQFYFYFF 108
Cdd:cd15067    4 VVLSLFcLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMP-FSILHEMTGGYWLFGRdwCDVWHSFDVL 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWM 152
Cdd:cd15067   83 ASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWI 126

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

30-151

3.20e-05

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 45.04 E-value: 3.20e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15312    4 YLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMML 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACW 151
Cdd:cd15312   84 STTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISW 125

7tmA_mAChR

cd15049

muscarinic acetylcholine receptor subfamily, member of the class A family of ...

38-135

3.55e-05

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341322 [Multi-domain] Cd Length: 262 Bit Score: 44.62 E-value: 3.55e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  38 LLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYF-YFFLGASEFLL 116
Cdd:cd15049   12 LVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALdYVASNASVMNL 91

                         90
                 ....*....|....*....
gi 283135120 117 LaVMSVDRYLAICRPLHYP 135
Cdd:cd15049   92 L-LISFDRYFSVTRPLTYR 109

7tmA_alpha1D_AR

cd15327

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

32-161

3.61e-05

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320450 [Multi-domain] Cd Length: 261 Bit Score: 44.52 E-value: 3.61e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLL-TLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPkmlsnFLSRRHTISFAA-----CITQFYF 105
Cdd:cd15327    5 VFLAIFILmAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLP-----FSATLEVLGFWAfgrvfCDIWAAV 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 283135120 106 YFFLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGP 161
Cdd:cd15327   80 DVLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGP 135

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

36-152

4.01e-05

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 44.42 E-value: 4.01e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  36 VYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITS-----VIIPKMLSNFLsrrhtisFAACITQFYFYFF-- 108
Cdd:cd15979   10 IFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVfcmpfTLIPNLMGTFI-------FGEVICKAVAYLMgv 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 283135120 109 -LGASEFLLLAVmSVDRYLAICRPLHYPLLMNGAVCFRVALACWM 152
Cdd:cd15979   83 sVSVSTFSLVAI-AIERYSAICNPLQSRVWQTRSHAYRVIAATWL 126

7tmA_alpha1B_AR

cd15326

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

38-161

5.98e-05

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320449 [Multi-domain] Cd Length: 261 Bit Score: 43.73 E-value: 5.98e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  38 LLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGASEFLLL 117
Cdd:cd15326   12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 283135120 118 AVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGP 161
Cdd:cd15326   92 CAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGP 135

7tmA_alpha-2D_AR

cd15324

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

32-136

6.20e-05

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320447 [Multi-domain] Cd Length: 256 Bit Score: 43.71 E-value: 6.20e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGA 111
Cdd:cd15324    6 VVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCT 85

                         90       100
                 ....*....|....*....|....*
gi 283135120 112 SEFLLLAVMSVDRYLAICRPLHYPL 136
Cdd:cd15324   86 SSIVHLCAISLDRYWSVTKAVSYNL 110

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

31-151

8.94e-05

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 43.74 E-value: 8.94e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  31 SVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLG 110
Cdd:cd15959    5 ALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCV 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 283135120 111 ASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACW 151
Cdd:cd15959   85 TASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVW 125

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

31-135

9.12e-05

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 43.12 E-value: 9.12e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  31 SVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLG 110
Cdd:cd15061    4 SFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVLLC 83

                         90       100
                 ....*....|....*....|....*
gi 283135120 111 ASEFLLLAVMSVDRYLAICRPLHYP 135
Cdd:cd15061   84 TASILNLCCISLDRYFAITYPLKYR 108

7tmA_QRFPR

cd15205

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...

30-132

1.22e-04

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.

Pssm-ID: 320333 [Multi-domain] Cd Length: 298 Bit Score: 43.23 E-value: 1.22e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIP-KMLSNFLSRRHTISFaACITQFYFYFF 108
Cdd:cd15205    4 VITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPfTLLQNISSNWLGGAF-MCKMVPFVQST 82

                         90       100
                 ....*....|....*....|....
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPL 132
Cdd:cd15205   83 AVVTSILTMTCIAVERHQGIVHPL 106

7tmA_NPYR-like

cd15203

neuropeptide Y receptors and related proteins, member of the class A family of ...

31-156

1.23e-04

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.

Pssm-ID: 320331 [Multi-domain] Cd Length: 293 Bit Score: 42.98 E-value: 1.23e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  31 SVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACitQFYFYFFlG 110
Cdd:cd15203    5 LLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILC--KLVPSLQ-G 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 283135120 111 ASEF---LLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALacWMGGLL 156
Cdd:cd15203   82 VSIFvstLTLTAIAIDRYQLIVYPTRPRMSKRHALLIIALI--WILSLL 128

PHA03087

G protein-coupled chemokine receptor-like protein; Provisional

23-134

1.29e-04

G protein-coupled chemokine receptor-like protein; Provisional

Pssm-ID: 222976 [Multi-domain] Cd Length: 335 Bit Score: 43.23 E-value: 1.29e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  23 NSTGAEVFSVFLFVylLTLTGNtLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIiPKMLSNFLSRRHTISFAACITQ 102
Cdd:PHA03087  39 NSTILIVVYSTIFF--FGLVGN-IIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTL-PFQIYYYILFQWSFGEFACKIV 114

                         90       100       110
                 ....*....|....*....|....*....|..
gi 283135120 103 FYFYFFLGASEFLLLAVMSVDRYLAICRPLHY 134
Cdd:PHA03087 115 SGLYYIGFYNSMNFITVMSVDRYIAIVHPVKS 146

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

34-134

1.54e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 42.59 E-value: 1.54e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  34 LFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFL-SRRHTISFAACITQFYFYFFLGAS 112
Cdd:cd15305    8 LIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILyDYAWPLPRYLCPIWISLDVLFSTA 87

                         90       100
                 ....*....|....*....|..
gi 283135120 113 EFLLLAVMSVDRYLAICRPLHY 134
Cdd:cd15305   88 SIMHLCAISLDRYVAIRNPIEH 109

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

35-173

1.93e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 42.63 E-value: 1.93e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  35 FVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLsnfLSRRH----TISFAAC-ITQFYFYFFL 109
Cdd:cd15217    9 LIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVL---VSIRNgsawTYSVLSCkIVAFMAVLFC 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 283135120 110 GASEFLLLAVmSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQ 173
Cdd:cd15217   86 FHAAFMLFCI-SVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFDVGTYKFIRE 148

7tmA_P2Y1-like

cd15168

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...

32-255

2.22e-04

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).

Pssm-ID: 341329 [Multi-domain] Cd Length: 284 Bit Score: 42.30 E-value: 2.22e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILItSVIIPKMLSNFLSRRHTI--SFAACITQFYFYFFL 109
Cdd:cd15168    6 VYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLY-LLSLPFLIYYYANGDHWIfgDFMCKLVRFLFYFNL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 110 GASeFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMggllpvlgpTVAVALLPfckqgavVQHFFCDSGPLLH 189
Cdd:cd15168   85 YGS-ILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWI---------LVLLQLLP-------ILFFATTGRKNNR 147

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 283135120 190 LACTNTTRLEEADFVLAFLVIMSSLT------ITGASYGHIVLAVLR----IPSASGRQKAFSTCtshLMVVTLFY 255
Cdd:cd15168  148 TTCYDTTSPEELNDYVIYSMVLTGLGfllpllIILACYGLIVRALIRklgeGVTSALRRKSIRLV---IIVLALFA 220

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

30-151

2.24e-04

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 42.16 E-value: 2.24e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPkmLSNFLSRRHTISFA--ACITQFYFYF 107
Cdd:cd15055    4 YIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMP--FSMIRSIETCWYFGdtFCKLHSSLDY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 283135120 108 FLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACW 151
Cdd:cd15055   82 ILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCW 125

7tmA_TAAR6_8_9

cd15316

trace amine-associated receptors 6, 8, and 9, member of the class A family of ...

29-135

2.71e-04

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320439 [Multi-domain] Cd Length: 290 Bit Score: 42.15 E-value: 2.71e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPkmLSNFLSRRHTISFAACITQFYFYF- 107
Cdd:cd15316    3 LYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMP--FSTVRSVESCWYFGESFCTFHTCCd 80

                         90       100
                 ....*....|....*....|....*....
gi 283135120 108 -FLGASEFLLLAVMSVDRYLAICRPLHYP 135
Cdd:cd15316   81 vSFCYASLFHLCFISVDRYIAVTDPLVYP 109

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

29-135

3.01e-04

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 41.55 E-value: 3.01e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFL-FVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYF 107
Cdd:cd15064    2 LISVLLsLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDV 81

                         90       100
                 ....*....|....*....|....*...
gi 283135120 108 FLGASEFLLLAVMSVDRYLAICRPLHYP 135
Cdd:cd15064   82 TCCTASILHLCVIALDRYWAITDAVEYA 109

7tmA_GPR17

cd15161

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...

29-132

3.57e-04

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.

Pssm-ID: 320289 [Multi-domain] Cd Length: 277 Bit Score: 41.62 E-value: 3.57e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLF-VYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEiLITSVIIPKMLSNFLSRRH-TISFAAC-ITQFYF 105
Cdd:cd15161    2 LFALFYIlVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVAD-LSYVLILPMRLVYHLSGNHwPFGEVPCrLAGFLF 80

                         90       100
                 ....*....|....*....|....*..
gi 283135120 106 YFFLGASEFLLlAVMSVDRYLAICRPL 132
Cdd:cd15161   81 YLNMYASLYFL-ACISVDRFLAIVHPV 106

7tmA_NPFFR

cd15207

neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...

29-131

3.57e-04

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.

Pssm-ID: 320335 [Multi-domain] Cd Length: 291 Bit Score: 41.84 E-value: 3.57e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSV-FLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIP-KMLSNFLSRRHTISFAACITQFYFY 106
Cdd:cd15207    2 LFIVsYSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPfTLVDNILTGWPFGDVMCKLSPLVQG 81

                         90       100
                 ....*....|....*....|....*
gi 283135120 107 FFLGASEFLLLAVmSVDRYLAICRP 131
Cdd:cd15207   82 VSVAASVFTLVAI-AVDRYRAVVHP 105

7tmA_mAChR_M5

cd15300

muscarinic acetylcholine receptor subtype M5, member of the class A family of ...

29-134

3.77e-04

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320427 [Multi-domain] Cd Length: 262 Bit Score: 41.55 E-value: 3.77e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15300    3 IAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYV 82

                         90       100
                 ....*....|....*....|....*.
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPLHY 134
Cdd:cd15300   83 ASNASVMNLLVISFDRYFSITRPLTY 108

7tmA_Prostanoid_R

cd14981

G protein-coupled receptors for prostanoids, member of the class A family of ...

29-180

5.56e-04

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320112 [Multi-domain] Cd Length: 288 Bit Score: 41.08 E-value: 5.56e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVylLTLTGN--TLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTI-SFAACITQFYF 105
Cdd:cd14981    5 APPALMFV--FGVLGNllALIVLARSSKSHKWSVFYRLVAGLAITDLLGILLTSPVVLAVYASNFEWDgGQPLCDYFGFM 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 283135120 106 YFFLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLpvlgptvaVALLPFCKQGAVVQHF 180
Cdd:cd14981   83 MSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALL--------IASLPLLGLGSYVLQY 149

7tm_GPCRs

cd14964

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...

30-163

5.86e-04

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410628 [Multi-domain] Cd Length: 267 Bit Score: 40.87 E-value: 5.86e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  30 FSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd14964    2 TIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGA 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTV 163
Cdd:cd14964   82 NLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLV 135

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

32-136

6.17e-04

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 40.74 E-value: 6.17e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIipkMLSNFLSRRHTI----SFAACITQFYFYF 107
Cdd:cd15390    6 VFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFN---TVFNFTYLLYNDwpfgLFYCKFSNFVAIT 82

                         90       100
                 ....*....|....*....|....*....
gi 283135120 108 FLGASEFLLLAvMSVDRYLAICRPLHYPL 136
Cdd:cd15390   83 TVAASVFTLMA-ISIDRYIAIVHPLRPRL 110

7tmA_Galanin_R-like

cd14971

galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...

29-133

7.65e-04

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320102 [Multi-domain] Cd Length: 281 Bit Score: 40.53 E-value: 7.65e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTI-SFAACITQFYFYF 107
Cdd:cd14971    3 VPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFgDFMCKFVHYFQQV 82

                         90       100
                 ....*....|....*....|....*.
gi 283135120 108 FLGASEFLLLAvMSVDRYLAICRPLH 133
Cdd:cd14971   83 SMHASIFTLVA-MSLDRFLAVVYPLR 107

7tmA_Beta1_AR

cd15958

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...

36-187

8.14e-04

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320624 [Multi-domain] Cd Length: 298 Bit Score: 40.66 E-value: 8.14e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  36 VYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPkmLSNFLSRRHTISFAACITQFYFYF--FLGASE 113
Cdd:cd15958   10 IVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVP--FGATLVVRGRWLYGSFFCELWTSVdvLCVTAS 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 283135120 114 FLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWmggllpvlGPTVAVALLPfckqgaVVQHFFCDSGPL 187
Cdd:cd15958   88 IETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVW--------AISALVSFLP------IMMHWWRDEDDQ 147

7tmA_GPR135

cd15212

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...

32-131

8.36e-04

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320340 [Multi-domain] Cd Length: 285 Bit Score: 40.52 E-value: 8.36e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTI-SFAACITQFYFYFFLG 110
Cdd:cd15212    6 VLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGWLfGDRLCLANGFFNACFG 85

                         90       100
                 ....*....|....*....|.
gi 283135120 111 ASEFLLLAVMSVDRYLAICRP 131
Cdd:cd15212   86 IVSTLTMTLISFDRYYAIVRQ 106

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

32-161

1.02e-03

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 40.25 E-value: 1.02e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIiPKMLSNFLSRRHTISFAACitqfYFYFFLGA 111
Cdd:cd15079    6 IYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKM-PIFIYNSFYEGWALGPLGC----QIYAFLGS 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 283135120 112 ----SEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALaCWMGGLLPVLGP 161
Cdd:cd15079   81 lsgiGSIWTNAAIAYDRYNVIVKPLNGNPLTRGKALLLILF-IWLYALPWALLP 133

7tmA_D4_dopamine_R

cd15308

D4 dopamine receptor of the D2-like family, member of the class A family of ...

27-134

1.07e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320434 [Multi-domain] Cd Length: 258 Bit Score: 40.20 E-value: 1.07e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  27 AEVFSVFLFvyLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKML-SNFLSRRHTISFAACITQFYF 105
Cdd:cd15308    3 ALVGGVLLI--LAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVySEFQGGVWTLSPVLCDALMTM 80

                         90       100
                 ....*....|....*....|....*....
gi 283135120 106 YFFLGASEFLLLAVMSVDRYLAICRPLHY 134
Cdd:cd15308   81 DVMLCTASIFNLCAISVDRFIAVSVPLNY 109

7tmA_Chemokine_R

cd14984

classical and atypical chemokine receptors, member of the class A family of ...

32-294

1.16e-03

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.

Pssm-ID: 341319 [Multi-domain] Cd Length: 278 Bit Score: 39.89 E-value: 1.16e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEIL--------ITSVIIPKMLSNFLsrrhtisfaaCITQF 103
Cdd:cd14984    6 LYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLfvltlpfwAVYAADGWVFGSFL----------CKLVS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 104 YFYFFLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLpvlgptVAVALLPFCKQGAVVQHFFCD 183
Cdd:cd14984   76 ALYTINFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALL------LSLPEFIFSQVSEENGSSICS 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 184 SGPLLHLACTNTTRLEEADFVLAFLVimsSLTITGASYGHIVLAVLRIPSaSGRQKAFSTCTSHLMV---------VTLF 254
Cdd:cd14984  150 YDYPEDTATTWKTLLRLLQNILGFLL---PLLVMLFCYSRIIRTLLRARN-HKKHRALRVIFAVVVVfflcwlpynIVLL 225

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 283135120 255 YGSAIFLYVRP---SQSGSVDTNWSVTVITTFVTPLLNPFIYA 294
Cdd:cd14984  226 LDTLQLLGIISrscELSKSLDYALQVTESLAFSHCCLNPVLYA 268

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

38-151

1.17e-03

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 40.23 E-value: 1.17e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  38 LLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPkmLSNFLSRRHTISFAACITQFYFYF---FLGASEF 114
Cdd:cd15318   12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLP--FSTIRSVESCWYFGDSFCRLHTCLdtlFCLTSIF 89

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 283135120 115 LLlAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACW 151
Cdd:cd15318   90 HL-CFISIDRHCAICDPLLYPSKFTIRVACIFIAAGW 125

7tmA_P2Y6_P2Y3-like

cd15968

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...

32-132

1.29e-03

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).

Pssm-ID: 320634 [Multi-domain] Cd Length: 285 Bit Score: 39.76 E-value: 1.29e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLScLEILITSVIIPKMLSNFLSRRHTI--SFAACITQFYFYFFL 109
Cdd:cd15968    6 CYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLA-LADLLYALSLPLLIYNYAMRDRWLfgDFMCRLVRFLFYFNL 84

                         90       100
                 ....*....|....*....|...
gi 283135120 110 GASeFLLLAVMSVDRYLAICRPL 132
Cdd:cd15968   85 YGS-ILFLTCISVHRYLGICHPM 106

7tmA_Histamine_H3R_H4R

cd15048

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...

32-134

1.42e-03

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320176 [Multi-domain] Cd Length: 296 Bit Score: 39.98 E-value: 1.42e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGA 111
Cdd:cd15048    6 LISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDYTLCT 85

                         90       100
                 ....*....|....*....|...
gi 283135120 112 SEFLLLAVMSVDRYLAICRPLHY 134
Cdd:cd15048   86 ASALTIVLISLDRYLSVTKAVKY 108

7tmA_motilin_R

cd15132

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

29-156

1.67e-03

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).

Pssm-ID: 320260 [Multi-domain] Cd Length: 289 Bit Score: 39.78 E-value: 1.67e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITsVIIPKMLSNFLSRRHTIsFAACITQFYFYFF 108
Cdd:cd15132    3 VTIVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLIL-LCLPFDLYRLWKSRPWI-FGEFLCRLYHYIS 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 283135120 109 LGA--SEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLL 156
Cdd:cd15132   81 EGCtyATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALL 130

7tmA_FFAR2_FFAR3

cd15170

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...

29-151

1.72e-03

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.

Pssm-ID: 320298 Cd Length: 278 Bit Score: 39.55 E-value: 1.72e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTL-IVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYF 107
Cdd:cd15170    3 VLAVYIITFLIGLPANLLaFYTFIRKVRRKPTPIDILLLNLTVSDLIFLLFLPFKMAEAASGMIWPLPYFLCPLSSFIFF 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 283135120 108 FLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACW 151
Cdd:cd15170   83 STIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFW 126

7tmA_D1A_dopamine_R

cd15320

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

33-151

1.75e-03

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320443 [Multi-domain] Cd Length: 319 Bit Score: 39.60 E-value: 1.75e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  33 FLFVYLL-TLTGNTLIVVLVGADHRLQTPMY-FFLANLSCLEILITSVIIP-KMLSNFLSRRHTISFaaCITQFYFYFFL 109
Cdd:cd15320    7 FLSVLILsTLLGNTLVCAAVIRFRHLRSKVTnFFVISLAVSDLLVAVLVMPwKAVAEIAGFWPFGSF--CNIWVAFDIMC 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 283135120 110 GASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACW 151
Cdd:cd15320   85 STASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAW 126

7tmA_5-HT2B

cd15306

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...

34-133

1.81e-03

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341347 [Multi-domain] Cd Length: 277 Bit Score: 39.43 E-value: 1.81e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  34 LFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFL-SRRHTISFAACITQFYFYFFLGAS 112
Cdd:cd15306    8 LMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILfEAMWPLPLVLCPIWLFLDVLFSTA 87

                         90       100
                 ....*....|....*....|.
gi 283135120 113 EFLLLAVMSVDRYLAICRPLH 133
Cdd:cd15306   88 SIMHLCAISLDRYIAIKKPIQ 108

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

36-132

2.03e-03

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 39.28 E-value: 2.03e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  36 VYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSV-IIPKMLSNFLSRRHTISFAACITQFYFYFFLGASEF 114
Cdd:cd14986   10 LFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFtVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLFASTY 89

                         90
                 ....*....|....*...
gi 283135120 115 LLLAvMSVDRYLAICRPL 132
Cdd:cd14986   90 ILVS-MSLDRYQAIVKPM 106

7tmA_mAChR_M2

cd15297

muscarinic acetylcholine receptor subtype M2, member of the class A family of ...

38-152

2.07e-03

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320424 [Multi-domain] Cd Length: 262 Bit Score: 39.18 E-value: 2.07e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  38 LLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGASEFLLL 117
Cdd:cd15297   12 LVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNL 91

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 283135120 118 AVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWM 152
Cdd:cd15297   92 LIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWV 126

7tmA_AstC_insect

cd15094

somatostatin-like receptor for allatostatin C, member of the class A family of ...

32-151

2.32e-03

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.

Pssm-ID: 320222 [Multi-domain] Cd Length: 282 Bit Score: 39.00 E-value: 2.32e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSC--------LEILITSVIIPK-MLSNFLSRRHTISFaaCITQ 102
Cdd:cd15094    6 LYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVadecfligLPFLIVTMILKYwPFGAAMCKIYMVLT--SINQ 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 283135120 103 FyfyfflgASEFLLLaVMSVDRYLAICRPLHYPLLMNGAVCFRVALACW 151
Cdd:cd15094   84 F-------TSSFTLT-VMSADRYLAVCHPIRSMRYRTPFIAKVVCATTW 124

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

28-134

2.51e-03

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 38.94 E-value: 2.51e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  28 EVFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSV-IIPKMLSNFLSRRHTISFAACITQFYFY 106
Cdd:cd15197    2 EQLATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLInVLTDIIWRITVEWRAGDFACKVIRYLQV 81

                         90       100
                 ....*....|....*....|....*...
gi 283135120 107 FFLGASEFLLLAvMSVDRYLAICRPLHY 134
Cdd:cd15197   82 VVTYASTYVLVA-LSIDRYDAICHPMNF 108

7tmA_V2R

cd15388

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...

36-132

2.65e-03

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320510 [Multi-domain] Cd Length: 295 Bit Score: 38.99 E-value: 2.65e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  36 VYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLsCLEILITSV--IIPKMLSNFLSRRHTISFAACITQFYFYFFLGASE 113
Cdd:cd15388   10 IFACALLSNSLVLLVLWRRRKQLARMHVFMLHL-CIADLVVAFfqVLPQLVWDITDRFRGPDVLCRLVKYLQVVGMFASS 88

                         90
                 ....*....|....*....
gi 283135120 114 FLLLAvMSVDRYLAICRPL 132
Cdd:cd15388   89 YMIVA-MTFDRHQAICRPM 106

7tmA_Beta2_AR

cd15957

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...

32-152

2.67e-03

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.

Pssm-ID: 341355 [Multi-domain] Cd Length: 301 Bit Score: 39.08 E-value: 2.67e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGA 111
Cdd:cd15957    6 VMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVT 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 283135120 112 SEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWM 152
Cdd:cd15957   86 ASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWI 126

7tmA_GPR26_GPR78-like

cd15219

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...

46-134

2.70e-03

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320347 [Multi-domain] Cd Length: 264 Bit Score: 38.98 E-value: 2.70e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  46 LIVVLVGADHRLQTPMyFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGASEFLLLAVMSVDRY 125
Cdd:cd15219   21 LLCFLYSAELRKQVPG-IFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTSNAMLSMAALSIDRW 99


                 ....*....
gi 283135120 126 LAICRPLHY 134
Cdd:cd15219  100 IAVVFPLSY 108

7tmA_Kappa_opioid_R

cd15091

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...

29-132

2.85e-03

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320219 [Multi-domain] Cd Length: 282 Bit Score: 38.78 E-value: 2.85e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIiPKMLSNFLSRRHTISFAACITQFYFYFF 108
Cdd:cd15091    3 ITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTM-PFQSTVYLMNSWPFGDVLCKIVISIDYY 81

                         90       100
                 ....*....|....*....|....
gi 283135120 109 LGASEFLLLAVMSVDRYLAICRPL 132
Cdd:cd15091   82 NMFTSIFTLTMMSVDRYIAVCHPV 105

7tmA_SREB2_GPR85

cd15218

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...

35-173

3.89e-03

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320346 [Multi-domain] Cd Length: 330 Bit Score: 38.47 E-value: 3.89e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  35 FVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRR---------HTISFAACITQFYF 105
Cdd:cd15218    9 FIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFTSVKNGStwtygtltcKVIAFLGVLSCFHT 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 283135120 106 YFflgaseflLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGPTVAVALLPFCKQ 173
Cdd:cd15218   89 AF--------MLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIRE 148

7tmA_mAChR_M4

cd15298

muscarinic acetylcholine receptor subtype M4, member of the class A family of ...

38-304

3.93e-03

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341344 [Multi-domain] Cd Length: 262 Bit Score: 38.46 E-value: 3.93e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  38 LLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYFFLGASEFLLL 117
Cdd:cd15298   12 LVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 118 AVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWmggLLPVLGPTVAVALLPFCKQGAVVQHFFCDSGPLLHLACTNTTR 197
Cdd:cd15298   92 LIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAW---VLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTA 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 198 LeeADFVLAfLVIMSSLtitgasYGHIVLAVLRIPSASgrQKAFSTCTSHLMVVTLFygSAIFLYVRPSQSGSVDTNWSV 277
Cdd:cd15298  169 I--AAFYLP-VVIMTVL------YIHISLASARERKVT--RTIFAILLAFILTWTPY--NVMVLVNTFCQSCIPDTVWSI 235

                        250       260
                 ....*....|....*....|....*..
gi 283135120 278 TVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15298  236 GYWLCYVNSTINPACYALCNATFKKTF 262

7tmA_D2-like_dopamine_R

cd15053

D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...

38-134

3.95e-03

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320181 [Multi-domain] Cd Length: 263 Bit Score: 38.48 E-value: 3.95e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  38 LLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKM-----------LSNFLSRRHTISFAACITqfyfy 106
Cdd:cd15053   12 LLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAvyvevnggkwyLGPILCDIYIAMDVMCST----- 86

                         90       100
                 ....*....|....*....|....*...
gi 283135120 107 fflgASEFLLLAVmSVDRYLAICRPLHY 134
Cdd:cd15053   87 ----ASIFNLCAI-SIDRYIAVTQPIKY 109

7tmA_Adenosine_R_A1

cd15071

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...

36-160

4.07e-03

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.

Pssm-ID: 341323 [Multi-domain] Cd Length: 290 Bit Score: 38.29 E-value: 4.07e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  36 VYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPkmLSNFLSRRHTISFAACITQFYFYFFLGASEFL 115
Cdd:cd15071   10 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAIIINIGPQTEFYSCLMVACPVLILTQSSIL 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 283135120 116 LLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWM----GGLLPVLG 160
Cdd:cd15071   88 ALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWIlsflVGLTPMFG 136

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

31-161

4.30e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 38.22 E-value: 4.30e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  31 SVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPkmLSNFLSRRHTISFAACITQFYFYFFLG 110
Cdd:cd15070    5 SIEILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLLVVFT 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 283135120 111 ASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLLPVLGP 161
Cdd:cd15070   83 HASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTP 133

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

31-132

4.62e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 38.26 E-value: 4.62e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  31 SVFLFVYLLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSV-IIPKMLSNFLSRRHTISFAACITQFYFYFFL 109
Cdd:cd15385    5 AVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFqVLPQLCWDITYRFYGPDFLCRIVKHLQVLGM 84

                         90       100
                 ....*....|....*....|...
gi 283135120 110 GASEFLLLaVMSVDRYLAICRPL 132
Cdd:cd15385   85 FASTYMLV-MMTADRYIAICHPL 106

7tmA_leucokinin-like

cd15393

leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...

38-132

4.68e-03

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.

Pssm-ID: 320515 [Multi-domain] Cd Length: 288 Bit Score: 38.16 E-value: 4.68e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  38 LLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAAC-ITQFYFYFFLGASEFLL 116
Cdd:cd15393   12 LVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCpFCPFVQVLSVNVSVFTL 91

                         90
                 ....*....|....*.
gi 283135120 117 LAVmSVDRYLAICRPL 132
Cdd:cd15393   92 TVI-AVDRYRAVIHPL 106

7tmA_NTSR2

cd15356

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...

31-155

5.88e-03

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.

Pssm-ID: 320478 [Multi-domain] Cd Length: 285 Bit Score: 37.92 E-value: 5.88e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  31 SVFLFVYLLTLTGNTLIVVLV---GADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFAACITQFYFYF 107
Cdd:cd15356    5 AVYALIWALGAAGNALTIHLVlkkRSLRGLQGTVHYHLVSLALSDLLILLISVPIELYNFVWFHYPWVFGDLVCRGYYFV 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 283135120 108 --FLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGL 155
Cdd:cd15356   85 rdICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSL 134

7tmA_AKHR

cd15382

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...

29-132

6.96e-03

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320504 [Multi-domain] Cd Length: 298 Bit Score: 37.68 E-value: 6.96e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGN-TLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKML----------SNFLSRrhtisfa 97
Cdd:cd15382    3 SIIVYSVLFLIAAVGNlTVLLILLRNRRRKRSRVNILLMHLAIADLLVTFIMMPLEIgwaatvawlaGDFLCR------- 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 283135120  98 acITQFYFYFFLGASEFLLLAvMSVDRYLAICRPL 132
Cdd:cd15382   76 --LMLFFRAFGLYLSSFVLVC-ISLDRYFAILKPL 107

7tmA_NTSR

cd15130

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

29-156

7.06e-03

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.

Pssm-ID: 320258 [Multi-domain] Cd Length: 281 Bit Score: 37.62 E-value: 7.06e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  29 VFSVFLFVYLLTLTGNTL---IVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISF--AACITQF 103
Cdd:cd15130    3 VTAIYLALFVVGTVGNSVtlfTLARKKSLQSLQSTVRYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFgdAGCRGYY 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 283135120 104 YFYFFLGASEFLLLAVMSVDRYLAICRPLHYPLLMNGAVCFRVALACWMGGLL 156
Cdd:cd15130   83 FLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASAL 135

7tmA_Gal2_Gal3_R

cd15097

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...

32-133

7.50e-03

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320225 [Multi-domain] Cd Length: 279 Bit Score: 37.50 E-value: 7.50e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  32 VFLFVYLLTLTGNTLIV-VLVGADHRLQTPMYFFLANLSCLEILITSVIIPkmlsnFLSRRHTI------SFAACITQFY 104
Cdd:cd15097    6 VFSLIFLLGTVGNSLVLaVLLRSGQSGHNTTNLFILNLSVADLCFILFCVP-----FQATIYSLegwvfgSFLCKAVHFF 80

                         90       100
                 ....*....|....*....|....*....
gi 283135120 105 FYFFLGASEFLLLAVmSVDRYLAICRPLH 133
Cdd:cd15097   81 IYLTMYASSFTLAAV-SVDRYLAIRYPLR 108

7tmA_GPR6

cd15962

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...

44-304

8.07e-03

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.

Pssm-ID: 320628 [Multi-domain] Cd Length: 268 Bit Score: 37.60 E-value: 8.07e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  44 NTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLSNFLSRRHTISFaacITQFYFYFFLGASEFLLLAVmSVD 123
Cdd:cd15962   18 NAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCGLILNFVFQYVIQSETISL---ITVGFLVASFTASVSSLLAI-TVD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 124 RYLAICRPLHYpllmngavCFRVALACWMGGLLPVLGPTVAVALLPFCKQGAVVQHFFCDSgpLLHLACTNTTRLEEADF 203
Cdd:cd15962   94 RYLSLYNALTY--------YSEKTVLGVHLMLAATWGVSLCLGLLPVLGWNCLEERASCSI--VRPLTKSNVTLLSASFF 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120 204 VLAFLVIMSSLTITGASYGH---IVLA--VLRIPSASGRQKAFSTctshLMVVTLFYGS-----AIFLYVRPSQSGSVDT 273
Cdd:cd15962  164 FIFILMLHLYIKICKIVCRHahqIALQqhFLTASHYVATKKGVST----LAIILGTFGAswlpfAIYCVVGDHEYPAVYT 239

                        250       260       270
                 ....*....|....*....|....*....|.
gi 283135120 274 nwSVTVITTFVTPLLNPFIYALRNDQVKEAL 304
Cdd:cd15962  240 --YATLLPATYNSMINPIIYAYRNQEIQRSM 268

7tmA_D3_dopamine_R

cd15310

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...

38-152

8.12e-03

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320436 [Multi-domain] Cd Length: 259 Bit Score: 37.26 E-value: 8.12e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135120  38 LLTLTGNTLIVVLVGADHRLQTPMYFFLANLSCLEILITSVIIPKMLS-NFLSRRHTISFAACITQFYFYFFLGASEFLL 116
Cdd:cd15310   12 LAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYlEVTGGVWNFSRICCDVFVTLDVMMCTASILN 91

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 283135120 117 LAVMSVDRYLAICRPLHYPLLMNGAVCFRVAL---ACWM 152
Cdd:cd15310   92 LCAISIDRYTAVVMPVHYQHGTGQSSCRRVSLmitAVWV 130

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01