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Conserved domains on  [gi|47086563|ref|NP_997904|]
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F-box only protein 42 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
 16-53 1.16e-18

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438882  Cd Length: 38  Bit Score: 79.30  E-value: 1.16e-18
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 47086563  16 MAELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKG 53
Cdd:cd22110   1 INDLPEEILEYILSYLSPYGDLKSAALVCKRWHRIIKG 38
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
79-289 4.23e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 72.88  E-value: 4.23e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563  79 PYPGTPITqRFSHSACYYDSnqSMYVFGGCTQSSCNaafNDLWRLDLNSKEWiRPLASGSYPsPKAGATLVMYGDLLVLF 158
Cdd:COG3055   5 SLPDLPTP-RSEAAAALLDG--KVYVAGGLSGGSAS---NSFEVYDPATNTW-SELAPLPGP-PRHHAAAVAQDGKLYVF 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563 159 GGWTRPSPYplhqpERFFDEIHTYSPSKNWWncivTTHGPPPMA--GHSSSVIRSTMVVFGGSLGARqMSNEVWVLDLEQ 236
Cdd:COG3055  77 GGFTGANPS-----STPLNDVYVYDPATNTW----TKLAPMPTPrgGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPAT 146

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 47086563 237 WTWSKPtisGPSPHPRGGQSQIVMDEETLLILGGCGGPNALLKDAWLLHMSDP 289
Cdd:COG3055 147 GTWTQL---APLPTPRDHLAAAVLPDGKILVIGGRNGSGFSNTWTTLAPLPTA 196
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 325-473 6.38e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 6.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563   325 QAPSGRAPLSPSlnsRPSPISSTPAPLGPDPPSLRSQSPVRSgAAGAVLGAVEEAPCVNGRWGTLRPRASARASSSSSPS 404
Cdd:PHA03247 2594 QSARPRAPVDDR---GDPRGPAPPSPLPPDTHAPDPPPPSPS-PAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARR 2669

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563   405 RGPDSPPLLNGASPSPRTSPVQQAS--------PPARPPGPADLSWDGSPP----------SANGLHTPPGSPRTPPGAV 466
Cdd:PHA03247 2670 LGRAAQASSPPQRPRRRAARPTVGSltsladppPPPPTPEPAPHALVSATPlppgpaaarqASPALPAAPAPPAVPAGPA 2749


                  ....*..
gi 47086563   467 SPAALRR 473
Cdd:PHA03247 2750 TPGGPAR 2756
 
Name Accession Description Interval E-value
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
 16-53 1.16e-18

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438882  Cd Length: 38  Bit Score: 79.30  E-value: 1.16e-18
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 47086563  16 MAELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKG 53
Cdd:cd22110   1 INDLPEEILEYILSYLSPYGDLKSAALVCKRWHRIIKG 38
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
79-289 4.23e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 72.88  E-value: 4.23e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563  79 PYPGTPITqRFSHSACYYDSnqSMYVFGGCTQSSCNaafNDLWRLDLNSKEWiRPLASGSYPsPKAGATLVMYGDLLVLF 158
Cdd:COG3055   5 SLPDLPTP-RSEAAAALLDG--KVYVAGGLSGGSAS---NSFEVYDPATNTW-SELAPLPGP-PRHHAAAVAQDGKLYVF 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563 159 GGWTRPSPYplhqpERFFDEIHTYSPSKNWWncivTTHGPPPMA--GHSSSVIRSTMVVFGGSLGARqMSNEVWVLDLEQ 236
Cdd:COG3055  77 GGFTGANPS-----STPLNDVYVYDPATNTW----TKLAPMPTPrgGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPAT 146

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 47086563 237 WTWSKPtisGPSPHPRGGQSQIVMDEETLLILGGCGGPNALLKDAWLLHMSDP 289
Cdd:COG3055 147 GTWTQL---APLPTPRDHLAAAVLPDGKILVIGGRNGSGFSNTWTTLAPLPTA 196
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 16-51 1.60e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 47.86  E-value: 1.60e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 47086563    16 MAELPEEVLEYILSFLSPyQEHKTAALVCKQWYRLI 51
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDP-KDLLRLALVCRRWRELA 35
Kelch_3 pfam13415
Galactose oxidase, central domain;
99-149 1.65e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 45.36  E-value: 1.65e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 47086563    99 NQSMYVFGGCTQSScNAAFNDLWRLDLNSKEWIRPlasGSYPSPKAGATLV 149
Cdd:pfam13415   1 GDKLYIFGGLGFDG-QTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSAT 47
PLN02193 PLN02193
nitrile-specifier protein
 55-241 1.18e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 48.03  E-value: 1.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563   55 AHQCYHGFLRAIQEGNiQWESRTyPYPGTPiTQRFSHSACYYDSNqsMYVFGGCtqsSCNAAFNDLWRLDLNSKEWIRPL 134
Cdd:PLN02193 239 ASRQYNGFYSFDTTTN-EWKLLT-PVEEGP-TPRSFHSMAADEEN--VYVFGGV---SATARLKTLDSYNIVDKKWFHCS 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563  135 ASGSYPSPKAGATL-VMYGDLLVLFGgwtrpspypLHQPErfFDEIHTYSPSKNWWNcIVTTHG--PPPMAGHSSSVIRS 211
Cdd:PLN02193 311 TPGDSFSIRGGAGLeVVQGKVWVVYG---------FNGCE--VDDVHYYDPVQDKWT-QVETFGvrPSERSVFASAAVGK 378

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 47086563  212 TMVVFGGSL--------GARQMSNEVWVLDLEQWTWSK 241
Cdd:PLN02193 379 HIVIFGGEIamdplahvGPGQLTDGTFALDTETLQWER 416
FBOX smart00256
A Receptor for Ubiquitination Targets;
19-52 2.82e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 41.27  E-value: 2.82e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 47086563     19 LPEEVLEYILSFLSPyQEHKTAALVCKQWYRLIK 52
Cdd:smart00256   1 LPDEILEEILSKLDP-KDLLRLRKVSRKWRSLID 33
PHA03247 PHA03247
large tegument protein UL36; Provisional
 325-473 6.38e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 6.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563   325 QAPSGRAPLSPSlnsRPSPISSTPAPLGPDPPSLRSQSPVRSgAAGAVLGAVEEAPCVNGRWGTLRPRASARASSSSSPS 404
Cdd:PHA03247 2594 QSARPRAPVDDR---GDPRGPAPPSPLPPDTHAPDPPPPSPS-PAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARR 2669

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563   405 RGPDSPPLLNGASPSPRTSPVQQAS--------PPARPPGPADLSWDGSPP----------SANGLHTPPGSPRTPPGAV 466
Cdd:PHA03247 2670 LGRAAQASSPPQRPRRRAARPTVGSltsladppPPPPTPEPAPHALVSATPlppgpaaarqASPALPAAPAPPAVPAGPA 2749


                  ....*..
gi 47086563   467 SPAALRR 473
Cdd:PHA03247 2750 TPGGPAR 2756
 
Name Accession Description Interval E-value
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
 16-53 1.16e-18

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438882  Cd Length: 38  Bit Score: 79.30  E-value: 1.16e-18
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 47086563  16 MAELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKG 53
Cdd:cd22110   1 INDLPEEILEYILSYLSPYGDLKSAALVCKRWHRIIKG 38
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
79-289 4.23e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 72.88  E-value: 4.23e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563  79 PYPGTPITqRFSHSACYYDSnqSMYVFGGCTQSSCNaafNDLWRLDLNSKEWiRPLASGSYPsPKAGATLVMYGDLLVLF 158
Cdd:COG3055   5 SLPDLPTP-RSEAAAALLDG--KVYVAGGLSGGSAS---NSFEVYDPATNTW-SELAPLPGP-PRHHAAAVAQDGKLYVF 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563 159 GGWTRPSPYplhqpERFFDEIHTYSPSKNWWncivTTHGPPPMA--GHSSSVIRSTMVVFGGSLGARqMSNEVWVLDLEQ 236
Cdd:COG3055  77 GGFTGANPS-----STPLNDVYVYDPATNTW----TKLAPMPTPrgGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPAT 146

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 47086563 237 WTWSKPtisGPSPHPRGGQSQIVMDEETLLILGGCGGPNALLKDAWLLHMSDP 289
Cdd:COG3055 147 GTWTQL---APLPTPRDHLAAAVLPDGKILVIGGRNGSGFSNTWTTLAPLPTA 196
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
72-284 3.92e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.10  E-value: 3.92e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563  72 QWESRTyPYPGTPItqrfSHSACYYDSNQsMYVFGGCTQSSCN-AAFNDLWRLDLNSKEWIRplaSGSYPSPKAGATLVM 150
Cdd:COG3055  49 TWSELA-PLPGPPR----HHAAAVAQDGK-LYVFGGFTGANPSsTPLNDVYVYDPATNTWTK---LAPMPTPRGGATALL 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563 151 YGDLLVLFGGWTRPSPYPLHQ-----------------PERFF-------DEIH-----TYSPSKNWWNciVTTHGPPPM 201
Cdd:COG3055 120 LDGKIYVVGGWDDGGNVAWVEvydpatgtwtqlaplptPRDHLaaavlpdGKILviggrNGSGFSNTWT--TLAPLPTAR 197

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563 202 AGHSSSVIRSTMVVFGGSLGArqmSNEVWVLDLEQWTWSKptiSGPSPHPRGGQSQIVMDEEtLLILGGCGGPNALLKDA 281
Cdd:COG3055 198 AGHAAAVLGGKILVFGGESGF---SDEVEAYDPATNTWTA---LGELPTPRHGHAAVLTDGK-VYVIGGETKPGVRTPLV 270


                ...
gi 47086563 282 WLL 284
Cdd:COG3055 271 TSA 273
F-box_AtTIR1-like cd22159
F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), ...
 16-51 1.29e-08

F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), coronatine-insensitive protein 1 (COI1) and similar proteins; TIR1, also called F-box/LRR-repeat protein 1 (FBL1), is part of an SCF (SKP1-cullin-F-box) protein ligase complex that promotes the ubiquitin-dependent proteolysis of a family of transcriptional regulators known as Aux/IAAs in an auxin-dependent manner. TIR1 is an auxin receptor that plays a potential role in plant hormone signaling. COI1, also called F-box/LRR-repeat protein 2 (FBL2), is the substrate-recruiting module of an SCF ubiquitin E3 ligase complex. It mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of transcriptional repressor JASMONATE ZIM-domain (JAZ) family proteins. This subfamily also includes Arabidopsis thaliana EIN3-binding F-box protein 1 (EBF1). EBF1, also called F-box/LRR-repeat protein 6 (FBL6), is a component of the SCF(EBF1) E3 ubiquitin ligase complex, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438930  Cd Length: 40  Bit Score: 50.93  E-value: 1.29e-08
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 47086563  16 MAELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLI 51
Cdd:cd22159   1 IDLLPDEILELIFSYLSDPWDRNSCSLVCKRWYRLE 36
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 17-52 1.41e-07

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 47.82  E-value: 1.41e-07
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 47086563  17 AELPEEVLEYILSFLSPyQEHKTAALVCKQWYRLIK 52
Cdd:cd09917   1 SDLPDEILLKILSYLDP-RDLLRLSLVCKRWRELAS 35
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 16-51 1.60e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 47.86  E-value: 1.60e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 47086563    16 MAELPEEVLEYILSFLSPyQEHKTAALVCKQWYRLI 51
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDP-KDLLRLALVCRRWRELA 35
Kelch_3 pfam13415
Galactose oxidase, central domain;
99-149 1.65e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 45.36  E-value: 1.65e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 47086563    99 NQSMYVFGGCTQSScNAAFNDLWRLDLNSKEWIRPlasGSYPSPKAGATLV 149
Cdd:pfam13415   1 GDKLYIFGGLGFDG-QTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSAT 47
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 18-52 2.63e-06

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 44.45  E-value: 2.63e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 47086563    18 ELPEEVLEYILSFLSPyQEHKTAALVCKQWYRLIK 52
Cdd:pfam00646   3 DLPDDLLLEILSRLDP-KDLLRLSLVSKRWRSLVD 36
PLN02193 PLN02193
nitrile-specifier protein
 55-241 1.18e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 48.03  E-value: 1.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563   55 AHQCYHGFLRAIQEGNiQWESRTyPYPGTPiTQRFSHSACYYDSNqsMYVFGGCtqsSCNAAFNDLWRLDLNSKEWIRPL 134
Cdd:PLN02193 239 ASRQYNGFYSFDTTTN-EWKLLT-PVEEGP-TPRSFHSMAADEEN--VYVFGGV---SATARLKTLDSYNIVDKKWFHCS 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563  135 ASGSYPSPKAGATL-VMYGDLLVLFGgwtrpspypLHQPErfFDEIHTYSPSKNWWNcIVTTHG--PPPMAGHSSSVIRS 211
Cdd:PLN02193 311 TPGDSFSIRGGAGLeVVQGKVWVVYG---------FNGCE--VDDVHYYDPVQDKWT-QVETFGvrPSERSVFASAAVGK 378

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 47086563  212 TMVVFGGSL--------GARQMSNEVWVLDLEQWTWSK 241
Cdd:PLN02193 379 HIVIFGGEIamdplahvGPGQLTDGTFALDTETLQWER 416
PRK14131 PRK14131
N-acetylneuraminate epimerase;
118-219 1.68e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 47.32  E-value: 1.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563  118 NDLWRLDLN--SKEWiRPLASgsYPS-PKAGATLVMYGDLLVLFGGWTRPSPYPLHQperFFDEIHTYSPSKNWWNcIVT 194
Cdd:PRK14131  50 TSWYKLDLNapSKGW-TKIAA--FPGgPREQAVAAFIDGKLYVFGGIGKTNSEGSPQ---VFDDVYKYDPKTNSWQ-KLD 122

                         90       100
                 ....*....|....*....|....*.
gi 47086563  195 THGPPPMAGHSSSVIRSTMVVF-GGS 219
Cdd:PRK14131 123 TRSPVGLAGHVAVSLHNGKAYItGGV 148
Kelch_4 pfam13418
Galactose oxidase, central domain;
88-136 1.89e-05

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 42.21  E-value: 1.89e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 47086563    88 RFSHSACYyDSNQSMYVFGGCTQSscNAAFNDLWRLDLNSKEWiRPLAS 136
Cdd:pfam13418   2 RAYHTSTS-IPDDTIYLFGGEGED--GTLLSDLWVFDLSTNEW-TRLGS 46
F-box_5 pfam18511
F-box; Jasmonates are a family of plant hormones that regulate plant growth, development and ...
 16-50 2.04e-05

F-box; Jasmonates are a family of plant hormones that regulate plant growth, development and responses to stress. COI1 is an F-box protein that functions as the substrate-recruiting module of the Skp1-Cul1-F-box protein (SCF) ubiquitin E3 ligase complex. The role of COI1-mediated JAZ degradation in jasmonate (JA) signaling is analogous to auxin signaling through the receptor F-box protein transport inhibitor response 1 (TIR1), which promotes hormone-dependent turnover of the AUX/IAA transcriptional repressors. The crystal structure of COI1 reveals a TIR1-like overall architecture, with an N-terminal tri-helical F-box motif bound to ASK1 and a C-terminal horseshoe-shaped solenoid domain formed by 18 tandem leucine-rich repeats. This entry represents the N-terminal F-box domain which is also found in other auxin signaling f-box proteins such as AFB1, AFB2 and AFB3.


Pssm-ID: 436553  Cd Length: 42  Bit Score: 41.79  E-value: 2.04e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 47086563    16 MAELPEEVLEYILSFLspyQEHK---TAALVCKQWYRL 50
Cdd:pfam18511   1 SDGFPDEVLECVLPYI---TSPRdrnAVSLVCKRWYRI 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
19-52 2.82e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 41.27  E-value: 2.82e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 47086563     19 LPEEVLEYILSFLSPyQEHKTAALVCKQWYRLIK 52
Cdd:smart00256   1 LPDEILEEILSKLDP-KDLLRLRKVSRKWRSLID 33
PLN02193 PLN02193
nitrile-specifier protein
 94-323 3.31e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 46.87  E-value: 3.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563   94 CYYDSNQ---SMYVFGGctQSSCNAAFND-LWRLDLNSKEWIRPLASGSYPSPKA-GATLVMYGDLLVLFGGwtrpspyp 168
Cdd:PLN02193 167 CSHGIAQvgnKIYSFGG--EFTPNQPIDKhLYVFDLETRTWSISPATGDVPHLSClGVRMVSIGSTLYVFGG-------- 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563  169 lHQPERFFDEIHTYSPSKNWWNCIV-TTHGPPPMAGHSSSVIRSTMVVFGGsLGARQMSNEVWVLDLEQWTWSKPTISGP 247
Cdd:PLN02193 237 -RDASRQYNGFYSFDTTTNEWKLLTpVEEGPTPRSFHSMAADEENVYVFGG-VSATARLKTLDSYNIVDKKWFHCSTPGD 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563  248 SPHPRGGQSQIVMDEETLLILG--GCGgpnalLKDawlLHMSDPC---WTwqqlRVENEDHGAPELWCHPACKVGQCVVV 322
Cdd:PLN02193 315 SFSIRGGAGLEVVQGKVWVVYGfnGCE-----VDD---VHYYDPVqdkWT----QVETFGVRPSERSVFASAAVGKHIVI 382


                 .
gi 47086563  323 F 323
Cdd:PLN02193 383 F 383
F-box_FBXL8 cd22121
F-box domain found in F-box/LRR-repeat protein 8 (FBXL8) and similar proteins; FBXL8, also ...
 18-48 3.84e-05

F-box domain found in F-box/LRR-repeat protein 8 (FBXL8) and similar proteins; FBXL8, also called F-box and leucine-rich repeat protein 8, or F-box protein FBL8, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438893  Cd Length: 35  Bit Score: 40.81  E-value: 3.84e-05
                        10        20        30
                ....*....|....*....|....*....|.
gi 47086563  18 ELPEEVLEYILSFLSpYQEHKTAALVCKQWY 48
Cdd:cd22121   2 ALPEEILVHIFRHLS-LRDRYAAAQVCKHWR 31
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 86-128 6.19e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 40.63  E-value: 6.19e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 47086563    86 TQRFSHSACYYDsnQSMYVFGGCTQSScNAAFNDLWRLDLNSK 128
Cdd:pfam13854   2 VPRYGHCAVTVG--DYIYLYGGYTGGE-GQPSDDVYVLSLPTF 41
Kelch_3 pfam13415
Galactose oxidase, central domain;
152-209 8.91e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 40.35  E-value: 8.91e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 47086563   152 GDLLVLFGGWTRPSpyplhqpERFFDEIHTYSPSKNWWncIVTTHGPPPMAGHSSSVI 209
Cdd:pfam13415   1 GDKLYIFGGLGFDG-------QTRLNDLYVYDLDTNTW--TQIGDLPPPRSGHSATYI 49
F-box_FBXO18 cd22095
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ...
 18-52 9.15e-05

F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438867  Cd Length: 48  Bit Score: 40.33  E-value: 9.15e-05
                        10        20        30
                ....*....|....*....|....*....|....*
gi 47086563  18 ELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIK 52
Cdd:cd22095   4 QLPEELLRNIFAFLPAEDLYQNISLVCRHWRDIVS 38
PLN02772 PLN02772
guanylate kinase
 197-289 1.01e-04

guanylate kinase


Pssm-ID: 215414 [Multi-domain]  Cd Length: 398  Bit Score: 45.21  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563  197 GPPPMAGHSSSVIRSTMVVFGGSLGARQMSNEVWVLDLEQWTWSKPTISGPSPHPRGGQSQIVMDEETLLILGGCGGPNa 276
Cdd:PLN02772  21 GVKPKNRETSVTIGDKTYVIGGNHEGNTLSIGVQILDKITNNWVSPIVLGTGPKPCKGYSAVVLNKDRILVIKKGSAPD- 99

                         90
                 ....*....|...
gi 47086563  277 llKDAWLLHMSDP 289
Cdd:PLN02772 100 --DSIWFLEVDTP 110
F-box_FBXO28 cd22100
F-box domain found in F-box only protein 28 (FBXO28) and similar proteins; FBXO28, also called ...
 18-46 1.22e-04

F-box domain found in F-box only protein 28 (FBXO28) and similar proteins; FBXO28, also called FBX28, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It promotes mitotic progression and regulates topoisomerase IIalpha-dependent DNA decatenation. FBXO28 plays a crucial role in the pathogenesis of the 1q41q42 microdeletion syndrome. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438872  Cd Length: 45  Bit Score: 39.84  E-value: 1.22e-04
                        10        20
                ....*....|....*....|....*....
gi 47086563  18 ELPEEVLEYILSFLSpYQEHKTAALVCKQ 46
Cdd:cd22100   3 ELPDEIIEKILSYLS-YDEISKLRLVCRR 30
F-box_FBXO45 cd22111
F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called ...
 16-50 2.07e-04

F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called FBX45, or F-box/SPRY domain-containing protein 1, functions as the substrate-recognition component of E3 ubiquitin ligase complexes. It is critical for synaptogenesis, neuronal migration, and synaptic transmission. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438883  Cd Length: 36  Bit Score: 38.80  E-value: 2.07e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 47086563  16 MAELPEEVLEYILSFLsPYQEHKTAALVCKQWYRL 50
Cdd:cd22111   1 AARLPSRVLEVIFSYL-DLPDLRNCSLVCKSWYRL 34
PLN02153 PLN02153
epithiospecifier protein
 82-270 3.11e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 43.44  E-value: 3.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563   82 GTPITQRFSHSACyyDSNQsMYVFGGCTQSSCNAA---FNDLWRLDLNSKEWIRPLASGSYPSPKAGAT-LVMYGDLLVL 157
Cdd:PLN02153 123 GGPEARTFHSMAS--DENH-VYVFGGVSKGGLMKTperFRTIEAYNIADGKWVQLPDPGENFEKRGGAGfAVVQGKIWVV 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563  158 FGGWTrpSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAG-HSSSVIRSTMVVFGGS--------LGARQMSNE 228
Cdd:PLN02153 200 YGFAT--SILPGGKSDYESNAVQFFDPASGKWTEVETTGAKPSARSvFAHAVVGKYIIIFGGEvwpdlkghLGPGTLSNE 277

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 47086563  229 VWVLDLEQWTWSKPTISGPSPHPRGGQS---QIVMDEETLLILGG 270
Cdd:PLN02153 278 GYALDTETLVWEKLGECGEPAMPRGWTAyttATVYGKNGLLMHGG 322
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 198-237 5.17e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.93  E-value: 5.17e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 47086563   198 PPPMAGHSSSVIRSTMVVFGG-SLGARQMSNEVWVLDLEQW 237
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGyTGGEGQPSDDVYVLSLPTF 41
F-box_DdgacFF-like cd22148
F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) ...
 19-51 5.32e-04

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438919  Cd Length: 44  Bit Score: 38.03  E-value: 5.32e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 47086563  19 LPEEVLEYILSFLSPyQEHKTAALVCKQWYRLI 51
Cdd:cd22148   5 LPEHLALKILSYLSP-KELLIASQVSKTWRRLA 36
F-box_AtSKIP19-like cd22164
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar ...
 18-52 6.35e-04

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438935 [Multi-domain]  Cd Length: 47  Bit Score: 37.96  E-value: 6.35e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 47086563  18 ELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIK 52
Cdd:cd22164   4 DLPDDLTASILSRLGAIDILTNAQKVCKLWRRICK 38
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
 19-51 1.07e-03

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438903  Cd Length: 40  Bit Score: 36.92  E-value: 1.07e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 47086563  19 LPEEVLEYILSFLSPYQEHkTAALVCKQWYRLI 51
Cdd:cd22131   6 LPLELSFYLLSFLDPESLL-TCCLVSKQWNKVI 37
Kelch_3 pfam13415
Galactose oxidase, central domain;
210-252 1.64e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.88  E-value: 1.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 47086563   210 RSTMVVFGGSLGARQ-MSNEVWVLDLEQWTWSKPtisGPSPHPR 252
Cdd:pfam13415   1 GDKLYIFGGLGFDGQtRLNDLYVYDLDTNTWTQI---GDLPPPR 41
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 19-50 1.82e-03

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 36.44  E-value: 1.82e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 47086563  19 LPEEVLEYILSFLSPyQEHKTAALVCKQWYRL 50
Cdd:cd22132   4 LPDSLLLHIFSYLSP-KDLLAAGQVCKQWYRV 34
F-box_unchar cd22138
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 ...
 19-52 2.90e-03

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 (FBXO13); The family corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 13 (FBXO13). FBXO13, also called FBX13, or F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438910  Cd Length: 45  Bit Score: 35.77  E-value: 2.90e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 47086563  19 LPEEVLEYILSFLSPyQEHKTAALVCKQWYRLIK 52
Cdd:cd22138   4 LPVECQLKIFSFLSE-VDKCLAATVCRSWSELIR 36
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 200-241 3.48e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 35.67  E-value: 3.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 47086563   200 PMAGHSSSVIRSTMVVFGGSLGARQMSNeVWVLDLEQWTWSK 241
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNS-VEVYDPETNTWSK 41
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 17-52 4.59e-03

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 35.13  E-value: 4.59e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 47086563  17 AELPEEVLEYILSFLsPYQEHKTAALVCKQWYRLIK 52
Cdd:cd22157   1 SSLPDDLVEEILSRL-PAKSLLRFRCVCKQWNSLIS 35
F-box_FBXO17-like cd22169
F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and ...
 16-53 5.17e-03

F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and similar proteins; This subfamily includes FBXO17 and FBXO27. FBXO17 is also called FBX17, F-box only protein 26 (FBX26/FBXO26), or FBG4, while FBXO27 is also called FBX27, or F-box/G-domain protein 5. FBXO17 and FBXO27 are the substrate-recognition components of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. They can recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. FBXO17 also recognizes sulfated glycans but does not bind high-mannose glycoproteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438940  Cd Length: 48  Bit Score: 35.47  E-value: 5.17e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 47086563  16 MAELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKG 53
Cdd:cd22169   1 LSLLPEELLLLVLSHVPARTLVTRCRLVCRDWRDLVDG 38
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 18-52 5.86e-03

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 35.02  E-value: 5.86e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 47086563  18 ELPEEVLEYILSFLsPYQEHKTAALVCKQWYRLIK 52
Cdd:cd22123   3 QLPENVLLEILSYL-PVRDLLRISRVCKRWRRLVY 36
PHA03247 PHA03247
large tegument protein UL36; Provisional
 325-473 6.38e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 6.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563   325 QAPSGRAPLSPSlnsRPSPISSTPAPLGPDPPSLRSQSPVRSgAAGAVLGAVEEAPCVNGRWGTLRPRASARASSSSSPS 404
Cdd:PHA03247 2594 QSARPRAPVDDR---GDPRGPAPPSPLPPDTHAPDPPPPSPS-PAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARR 2669

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086563   405 RGPDSPPLLNGASPSPRTSPVQQAS--------PPARPPGPADLSWDGSPP----------SANGLHTPPGSPRTPPGAV 466
Cdd:PHA03247 2670 LGRAAQASSPPQRPRRRAARPTVGSltsladppPPPPTPEPAPHALVSATPlppgpaaarqASPALPAAPAPPAVPAGPA 2749


                  ....*..
gi 47086563   467 SPAALRR 473
Cdd:PHA03247 2750 TPGGPAR 2756
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
 16-51 8.62e-03

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 34.60  E-value: 8.62e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 47086563  16 MAELPEEVLEYILSFLspyqEHKT---AALVCKQWYRLI 51
Cdd:cd22147   2 LSALPVELSLKILSYL----DAKSlcrAAQVSKKWRNLA 36
F-box_FBXL1 cd22114
F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also ...
 18-50 8.90e-03

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438886  Cd Length: 41  Bit Score: 34.31  E-value: 8.90e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 47086563  18 ELPEEVLEYILSFLsPYQEHKTAALVCKQWYRL 50
Cdd:cd22114   3 SLPDELLLGIFSCL-CLPDLLKVSQVCKRWYRL 34
F-box_FBXO33 cd22104
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called ...
 19-49 9.59e-03

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438876  Cd Length: 48  Bit Score: 34.54  E-value: 9.59e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 47086563  19 LPEEVLEYILSFLSPyQEHKTAALVCKQWYR 49
Cdd:cd22104   4 LPSVVLVHIFSYLPP-RDRLRASSTCRRWRE 33
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
 19-52 9.74e-03

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 34.24  E-value: 9.74e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 47086563  19 LPEEVLEYILSFLSPyQEHKTAALVCKQWYRLIK 52
Cdd:cd22118   4 LPPEIMLKIFSYLNP-QDLCRCAQVCTKWSQLAR 36
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
 19-50 9.94e-03

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 34.53  E-value: 9.94e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 47086563  19 LPEEVLEYILSFLSPyQEHKTAALVCKQWYRL 50
Cdd:cd22139   4 LPDELWLHIFSFLSP-KDLCQVALVCRRFNRL 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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