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Conserved domains on  [gi|47458050|ref|NP_998817|]
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hemojuvelin isoform c [Homo sapiens]

Protein Classification

RGM_C domain-containing protein( domain architecture ID 10534809)

RGM_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RGM_C pfam06534
Repulsive guidance molecule (RGM) C-terminus; This family consists of several mammalian and ...
 4-163 1.59e-84

Repulsive guidance molecule (RGM) C-terminus; This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.


:

Pssm-ID: 461939  Cd Length: 171  Bit Score: 247.15  E-value: 1.59e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458050     4 CIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFS 83
Cdd:pfam06534   1 CTDQKVYQAETDDLPAAFVDGTTNGGDRDGGNSLRILEKEPGRHVEIHARYIGTTIIVRQVGRYLTFAIRMPEEVANALE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458050    84 AEQDLQLCVGGCPPSQR------LSRSERN-----RRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQ 152
Cdd:pfam06534  81 EDQDLQLCVNGCPRSERidyrtlLAEPVKRtacyqPRVAFTLESATAKCRESLPVEDVYFQSCVFDLLTTGDANFTLAAY 160

                         170
                  ....*....|.
gi 47458050   153 AALEDARAFLP 163
Cdd:pfam06534 161 SALEDVKRLHP 171
 
Name Accession Description Interval E-value
RGM_C pfam06534
Repulsive guidance molecule (RGM) C-terminus; This family consists of several mammalian and ...
 4-163 1.59e-84

Repulsive guidance molecule (RGM) C-terminus; This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.


Pssm-ID: 461939  Cd Length: 171  Bit Score: 247.15  E-value: 1.59e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458050     4 CIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFS 83
Cdd:pfam06534   1 CTDQKVYQAETDDLPAAFVDGTTNGGDRDGGNSLRILEKEPGRHVEIHARYIGTTIIVRQVGRYLTFAIRMPEEVANALE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458050    84 AEQDLQLCVGGCPPSQR------LSRSERN-----RRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQ 152
Cdd:pfam06534  81 EDQDLQLCVNGCPRSERidyrtlLAEPVKRtacyqPRVAFTLESATAKCRESLPVEDVYFQSCVFDLLTTGDANFTLAAY 160

                         170
                  ....*....|.
gi 47458050   153 AALEDARAFLP 163
Cdd:pfam06534 161 SALEDVKRLHP 171
 
Name Accession Description Interval E-value
RGM_C pfam06534
Repulsive guidance molecule (RGM) C-terminus; This family consists of several mammalian and ...
 4-163 1.59e-84

Repulsive guidance molecule (RGM) C-terminus; This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.


Pssm-ID: 461939  Cd Length: 171  Bit Score: 247.15  E-value: 1.59e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458050     4 CIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFS 83
Cdd:pfam06534   1 CTDQKVYQAETDDLPAAFVDGTTNGGDRDGGNSLRILEKEPGRHVEIHARYIGTTIIVRQVGRYLTFAIRMPEEVANALE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458050    84 AEQDLQLCVGGCPPSQR------LSRSERN-----RRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQ 152
Cdd:pfam06534  81 EDQDLQLCVNGCPRSERidyrtlLAEPVKRtacyqPRVAFTLESATAKCRESLPVEDVYFQSCVFDLLTTGDANFTLAAY 160

                         170
                  ....*....|.
gi 47458050   153 AALEDARAFLP 163
Cdd:pfam06534 161 SALEDVKRLHP 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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