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Conserved domains on  [gi|47550731|ref|NP_999890|]
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ankyrin repeat and SOCS box protein 2b [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-275 7.30e-45

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 160.50  E-value: 7.30e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   4 FSYAEYISLFRTNDKTANPRRQKTHTHRCGGAEARHEPAQAGPSGAEVLDGDDWTPLHEAAYRGQNHCLQALLREGQVCV 83
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  84 DKRTLQEETALMLAVQARQLECVRILLEAGADPDICNKSKETPLYRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHAA 163
Cdd:COG0666  81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731 164 AERGCVQICVCLLRAGASRDARCAQLNTPAVEAARHGHTHTLELLMQNGAAVDLQTSDGYTPLMEACRHGHTDAVRVLLK 243
Cdd:COG0666 161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240

                       250       260       270
                ....*....|....*....|....*....|..
gi 47550731 244 HHADTHRASADGLLPLHVASQHGHHRIVSILL 275
Cdd:COG0666 241 AGADLNAKDKDGLTALLLAAAAGAALIVKLLL 272
PHA03095 super family cl33707
ankyrin-like protein; Provisional
 236-421 2.71e-13

ankyrin-like protein; Provisional


The actual alignment was detected with superfamily member PHA03095:

Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 71.98  E-value: 2.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  236 DAVRVLLKHHADTHRASADGLLPLHVASQHGHH---RIVSILLPITSRWRLRQS-GISPLHLAAERGH-LRVLELLIGSG 310
Cdd:PHA03095  28 EEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEkvkDIVRLLLEAGADVNAPERcGFTPLHLYLYNATtLDVIKLLIKAG 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  311 CDVNSRlsdersaVFADRRVSPLYCAVAAGRTEVAAALLRAGADPE---LDPFSPL--LLAARQACVRTVELLLRSGAHA 385
Cdd:PHA03095 108 ADVNAK-------DKVGRTPLHVYLSGFNINPKVIRLLLRKGADVNaldLYGMTPLavLLKSRNANVELLRLLIDAGADV 180

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 47550731  386 NTHPPTHNTtfpaaLLHTHQL------EVLRELLEHGCDAHA 421
Cdd:PHA03095 181 YAVDDRFRS-----LLHHHLQsfkpraRIVRELIRAGCDPAA 217
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 499-539 1.65e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239641  Cd Length: 41  Bit Score: 61.72  E-value: 1.65e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 47550731 499 SPRALVHLCRLQIRHQLGTHRLNSIRSLPLPERLQRYLTSR 539
Cdd:cd03587   1 NPRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-275 7.30e-45

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 160.50  E-value: 7.30e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   4 FSYAEYISLFRTNDKTANPRRQKTHTHRCGGAEARHEPAQAGPSGAEVLDGDDWTPLHEAAYRGQNHCLQALLREGQVCV 83
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  84 DKRTLQEETALMLAVQARQLECVRILLEAGADPDICNKSKETPLYRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHAA 163
Cdd:COG0666  81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731 164 AERGCVQICVCLLRAGASRDARCAQLNTPAVEAARHGHTHTLELLMQNGAAVDLQTSDGYTPLMEACRHGHTDAVRVLLK 243
Cdd:COG0666 161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240

                       250       260       270
                ....*....|....*....|....*....|..
gi 47550731 244 HHADTHRASADGLLPLHVASQHGHHRIVSILL 275
Cdd:COG0666 241 AGADLNAKDKDGLTALLLAAAAGAALIVKLLL 272
Ank_2 pfam12796
Ankyrin repeats (3 copies);
226-316 9.28e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 84.01  E-value: 9.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   226 LMEACRHGHTDAVRVLLKHHADTHRASADGLLPLHVASQHGHHRIVSILLPITSRwRLRQSGISPLHLAAERGHLRVLEL 305
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV-NLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|.
gi 47550731   306 LIGSGCDVNSR 316
Cdd:pfam12796  80 LLEKGADINVK 90
PHA03095 PHA03095
ankyrin-like protein; Provisional
 103-392 3.07e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 78.14  E-value: 3.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  103 LECVRILLEAGADPDICNKSKETPL-YRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHaaaergcvqicVCLlragas 181
Cdd:PHA03095  63 KDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLH-----------VYL------ 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  182 rdarcAQLNTpaveaarhgHTHTLELLMQNGAAVDLQTSDGYTPLmeACRHGHTDA----VRVLLKHHADTHRASADGLL 257
Cdd:PHA03095 126 -----SGFNI---------NPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNAnvelLRLLIDAGADVYAVDDRFRS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  258 PLHVASQHGHHR--IVSILLPITSRWRLRQ-SGISPLHLAAERGHLR--VLELLIGSGCDVNSRlsdersavfaDRR-VS 331
Cdd:PHA03095 190 LLHHHLQSFKPRarIVRELIRAGCDPAATDmLGNTPLHSMATGSSCKrsLVLPLLIAGISINAR----------NRYgQT 259

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47550731  332 PLYCAVAAGRTEVAAALLRAGADPEL---DPFSPLLLAARQACVRTVELLLrsgahaNTHPPTH 392
Cdd:PHA03095 260 PLHYAAVFNNPRACRRLIALGADINAvssDGNTPLSLMVRNNNGRAVRAAL------AKNPSAE 317
PHA03095 PHA03095
ankyrin-like protein; Provisional
 236-421 2.71e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 71.98  E-value: 2.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  236 DAVRVLLKHHADTHRASADGLLPLHVASQHGHH---RIVSILLPITSRWRLRQS-GISPLHLAAERGH-LRVLELLIGSG 310
Cdd:PHA03095  28 EEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEkvkDIVRLLLEAGADVNAPERcGFTPLHLYLYNATtLDVIKLLIKAG 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  311 CDVNSRlsdersaVFADRRVSPLYCAVAAGRTEVAAALLRAGADPE---LDPFSPL--LLAARQACVRTVELLLRSGAHA 385
Cdd:PHA03095 108 ADVNAK-------DKVGRTPLHVYLSGFNINPKVIRLLLRKGADVNaldLYGMTPLavLLKSRNANVELLRLLIDAGADV 180

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 47550731  386 NTHPPTHNTtfpaaLLHTHQL------EVLRELLEHGCDAHA 421
Cdd:PHA03095 181 YAVDDRFRS-----LLHHHLQsfkpraRIVRELIRAGCDPAA 217
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 499-539 1.65e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 61.72  E-value: 1.65e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 47550731 499 SPRALVHLCRLQIRHQLGTHRLNSIRSLPLPERLQRYLTSR 539
Cdd:cd03587   1 NPRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
Ank_2 pfam12796
Ankyrin repeats (3 copies);
291-387 9.13e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.29  E-value: 9.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   291 LHLAAERGHLRVLELLIGSGCDVNSRLSDERsavfadrrvSPLYCAVAAGRTEVAAALLR-AGADPELDPFSPLLLAARQ 369
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGR---------TALHLAAKNGHLEIVKLLLEhADVNLKDNGRTALHYAARS 71

                          90
                  ....*....|....*...
gi 47550731   370 ACVRTVELLLRSGAHANT 387
Cdd:pfam12796  72 GHLEIVKLLLEKGADINV 89
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 499-537 4.26e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 54.86  E-value: 4.26e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 47550731   499 SPRALVHLCRLQIRHQLGTHRLNSIRSLPLPERLQRYLT 537
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 224-355 4.07e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 56.17  E-value: 4.07e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731 224 TPLMEACRHGHTDAVRVLLK-HHADTHRASADGLLPLHVASQHGHHRIVSILL---------PITSRWRLrqsGISPLHL 293
Cdd:cd22192  19 SPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMeaapelvnePMTSDLYQ---GETALHI 95

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731 294 AAERGHLRVLELLIGSGCDVNS-RLSderSAVFADRRVS-------PLYCAVAAGRTEVAAALLRAGADP 355
Cdd:cd22192  96 AVVNQNLNLVRELIARGADVVSpRAT---GTFFRPGPKNliyygehPLSFAACVGNEEIVRLLIEHGADI 162
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 501-539 1.72e-05

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 41.63  E-value: 1.72e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 47550731    501 RALVHLCRLQIRHQLGThrlnsIRSLPLPERLQRYLTSR 539
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 287-314 9.61e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 9.61e-05
                           10        20
                   ....*....|....*....|....*...
gi 47550731    287 GISPLHLAAERGHLRVLELLIGSGCDVN 314
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 221-249 1.22e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.11  E-value: 1.22e-04
                           10        20
                   ....*....|....*....|....*....
gi 47550731    221 DGYTPLMEACRHGHTDAVRVLLKHHADTH 249
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 53-162 5.41e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 42.82  E-value: 5.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  53 DGDDWTPLHEAAYRGQNHclqallrEGQvcvdkrtlqeeTALMLAVQARQLECVRILLEAGADPDICNKSK--------- 123
Cdd:cd22194 122 ENGILDRFINAEYTEEAY-------EGQ-----------TALNIAIERRQGDIVKLLIAKGADVNAHAKGVffnpkykhe 183

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47550731 124 -----ETPLYRACEQECVQMVEVLLQRGA-VVDQRCVRGRSALHA 162
Cdd:cd22194 184 gfyfgETPLALAACTNQPEIVQLLMEKEStDITSQDSRGNTVLHA 228
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-275 7.30e-45

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 160.50  E-value: 7.30e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   4 FSYAEYISLFRTNDKTANPRRQKTHTHRCGGAEARHEPAQAGPSGAEVLDGDDWTPLHEAAYRGQNHCLQALLREGQVCV 83
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  84 DKRTLQEETALMLAVQARQLECVRILLEAGADPDICNKSKETPLYRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHAA 163
Cdd:COG0666  81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731 164 AERGCVQICVCLLRAGASRDARCAQLNTPAVEAARHGHTHTLELLMQNGAAVDLQTSDGYTPLMEACRHGHTDAVRVLLK 243
Cdd:COG0666 161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240

                       250       260       270
                ....*....|....*....|....*....|..
gi 47550731 244 HHADTHRASADGLLPLHVASQHGHHRIVSILL 275
Cdd:COG0666 241 AGADLNAKDKDGLTALLLAAAAGAALIVKLLL 272
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
49-321 9.84e-44

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 157.42  E-value: 9.84e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  49 AEVLDGDDWTPLHEAAYRGQNHCLQALLREGQVCVDKRTLQEETALMLAVQARQLECVRILLEAGADPDICNKSKETPLY 128
Cdd:COG0666  13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLH 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731 129 RACEQECVQMVEVLLQRGAVVDQRCVRGRSALHAAAERGCVQICVCLLRAGASRDARCAQLNTPAVEAARHGHTHTLELL 208
Cdd:COG0666  93 AAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731 209 MQNGAAVDLQTSDGYTPLMEACRHGHTDAVRVLLKHHADTHRASADGLLPLHVASQHGHHRIVSILLPITSRWRLR-QSG 287
Cdd:COG0666 173 LEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKdKDG 252

                       250       260       270
                ....*....|....*....|....*....|....
gi 47550731 288 ISPLHLAAERGHLRVLELLIGSGCDVNSRLSDER 321
Cdd:COG0666 253 LTALLLAAAAGAALIVKLLLLALLLLAAALLDLL 286
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-259 7.64e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 149.33  E-value: 7.64e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  16 NDKTANPRRQKTHTHRCGGAEARHEPAQAGPSGAEVLDGDDWTPLHEAAYRGQNHCLQALLREGQVcVDKRTLQEETALM 95
Cdd:COG0666  47 LALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD-VNARDKDGETPLH 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  96 LAVQARQLECVRILLEAGADPDICNKSKETPLYRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHAAAERGCVQICVCL 175
Cdd:COG0666 126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731 176 LRAGASRDARCAQLNTPAVEAARHGHTHTLELLMQNGAAVDLQTSDGYTPLMEACRHGHTDAVRVLLKHHADTHRASADG 255
Cdd:COG0666 206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285


                ....
gi 47550731 256 LLPL 259
Cdd:COG0666 286 LTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
83-358 2.10e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 145.48  E-value: 2.10e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  83 VDKRTLQEETALMLAVQARQLECVRILLEAGADPDICNKSKETPLYRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHA 162
Cdd:COG0666  14 ALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731 163 AAERGCVQICVCLLRAGASRDARCAQLNTPAVEAARHGHTHTLELLMQNGAAVDLQTSDGYTPLMEACRHGHTDAVRVLL 242
Cdd:COG0666  94 AARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731 243 KHHADTHRASADGLLPLHVASQHGHHRIVSILL----PITSRwrlRQSGISPLHLAAERGHLRVLELLIGSGCDVNSRLS 318
Cdd:COG0666 174 EAGADVNARDNDGETPLHLAAENGHLEIVKLLLeagaDVNAK---DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDK 250

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47550731 319 DERSAvfadrrvspLYCAVAAGRTEVAAALLRAGADPELD 358
Cdd:COG0666 251 DGLTA---------LLLAAAAGAALIVKLLLLALLLLAAA 281
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
106-414 8.88e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 141.24  E-value: 8.88e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731 106 VRILLEAGADPDICNKSKETPLYRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHAAAERGCVQICVCLLRAGASRDAR 185
Cdd:COG0666   4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731 186 CAQLNTPAVEAARHGHTHTLELLMQNGAAVDLQTSDGYTPLMEACRHGHTDAVRVLLKHHADTHRASADGllplhvasqh 265
Cdd:COG0666  84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDG---------- 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731 266 ghhrivsillpitsrwrlrqsgISPLHLAAERGHLRVLELLIGSGCDVNSRLSDERsavfadrrvSPLYCAVAAGRTEVA 345
Cdd:COG0666 154 ----------------------NTPLHLAAANGNLEIVKLLLEAGADVNARDNDGE---------TPLHLAAENGHLEIV 202

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47550731 346 AALLRAGADPEL---DPFSPLLLAARQACVRTVELLLRSGAHANTHPPTHNTTFPAALLHTHQLEVLRELLE 414
Cdd:COG0666 203 KLLLEAGADVNAkdnDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLA 274
Ank_2 pfam12796
Ankyrin repeats (3 copies);
226-316 9.28e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 84.01  E-value: 9.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   226 LMEACRHGHTDAVRVLLKHHADTHRASADGLLPLHVASQHGHHRIVSILLPITSRwRLRQSGISPLHLAAERGHLRVLEL 305
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV-NLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|.
gi 47550731   306 LIGSGCDVNSR 316
Cdd:pfam12796  80 LLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
196-275 4.58e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 79.39  E-value: 4.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   196 AARHGHTHTLELLMQNGAAVDLQTSDGYTPLMEACRHGHTDAVRVLLKhHADThRASADGLLPLHVASQHGHHRIVSILL 275
Cdd:pfam12796   4 AAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADV-NLKDNGRTALHYAARSGHLEIVKLLL 81
Ank_2 pfam12796
Ankyrin repeats (3 copies);
160-247 6.20e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.23  E-value: 6.20e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   160 LHAAAERGCVQICVCLLRAGASRDARCAQLNTPAVEAARHGHTHTLELLMQNgAAVDLQTsDGYTPLMEACRHGHTDAVR 239
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ....*...
gi 47550731   240 VLLKHHAD 247
Cdd:pfam12796  79 LLLEKGAD 86
Ank_2 pfam12796
Ankyrin repeats (3 copies);
94-181 1.64e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.07  E-value: 1.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731    94 LMLAVQARQLECVRILLEAGADPDICNKSKETPLYRACEQECVQMVEVLLQRGAVvdQRCVRGRSALHAAAERGCVQICV 173
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78


                  ....*...
gi 47550731   174 CLLRAGAS 181
Cdd:pfam12796  79 LLLEKGAD 86
PHA03095 PHA03095
ankyrin-like protein; Provisional
 103-392 3.07e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 78.14  E-value: 3.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  103 LECVRILLEAGADPDICNKSKETPL-YRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHaaaergcvqicVCLlragas 181
Cdd:PHA03095  63 KDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLH-----------VYL------ 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  182 rdarcAQLNTpaveaarhgHTHTLELLMQNGAAVDLQTSDGYTPLmeACRHGHTDA----VRVLLKHHADTHRASADGLL 257
Cdd:PHA03095 126 -----SGFNI---------NPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNAnvelLRLLIDAGADVYAVDDRFRS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  258 PLHVASQHGHHR--IVSILLPITSRWRLRQ-SGISPLHLAAERGHLR--VLELLIGSGCDVNSRlsdersavfaDRR-VS 331
Cdd:PHA03095 190 LLHHHLQSFKPRarIVRELIRAGCDPAATDmLGNTPLHSMATGSSCKrsLVLPLLIAGISINAR----------NRYgQT 259

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47550731  332 PLYCAVAAGRTEVAAALLRAGADPEL---DPFSPLLLAARQACVRTVELLLrsgahaNTHPPTH 392
Cdd:PHA03095 260 PLHYAAVFNNPRACRRLIALGADINAvssDGNTPLSLMVRNNNGRAVRAAL------AKNPSAE 317
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 90-354 1.96e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 75.41  E-value: 1.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   90 EETALMLAVQARQLECVRILLEAGADPDICNKSKETPLYRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHAAAERGCV 169
Cdd:PHA02875   2 DQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  170 QicvcllragasrdarcaqlntpAVEaarhghthtlELLMQNGAAVDLQTSDGYTPLMEACRHGHTDAVRVLLKHHADTH 249
Cdd:PHA02875  82 K----------------------AVE----------ELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPD 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  250 RASADGLLPLHVASQHGHHRIVSILLPITSRWRLRQS-GISPLHLAAERGHLRVLELLIGSGCDVNsrlsdersavFADR 328
Cdd:PHA02875 130 IPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCcGCTPLIIAMAKGDIAICKMLLDSGANID----------YFGK 199

                        250       260
                 ....*....|....*....|....*...
gi 47550731  329 R--VSPLYCAVAAGRTEVAAALLRAGAD 354
Cdd:PHA02875 200 NgcVAALCYAIENNKIDIVRLFIKRGAD 227
Ank_2 pfam12796
Ankyrin repeats (3 copies);
60-152 2.91e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.22  E-value: 2.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731    60 LHEAAYRGQNHCLQALLREGQVcVDKRTLQEETALMLAVQARQLECVRILLEaGADPDICNKsKETPLYRACEQECVQMV 139
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD-ANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIV 77

                          90
                  ....*....|...
gi 47550731   140 EVLLQRGAVVDQR 152
Cdd:pfam12796  78 KLLLEKGADINVK 90
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 47-275 5.06e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 75.10  E-value: 5.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   47 SGAEVLDGDDW--TPLHEAAYRGQNHCLQALLREGQVCVDKRTLQEETAL-MLAVQARQLECVRILLEAGADPDICNKSK 123
Cdd:PHA02876 262 AGFSVNSIDDCknTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLyLMAKNGYDTENIRTLIMLGADVNAADRLY 341

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  124 ETPLYRACEQECVQ-MVEVLLQRGAVVDQRCVRGRSALHAAAERGCVQICVCLLRAGASRDARCAQLNTpAVEAARHGHT 202
Cdd:PHA02876 342 ITPLHQASTLDRNKdIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGT-ALHFALCGTN 420

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47550731  203 --HTLELLMQNGAAVDLQTSDGYTPLMEACRHG-HTDAVRVLLKHHADTHRASADGLLPLHVASqhGHHRIVSILL 275
Cdd:PHA02876 421 pyMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILL 494
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 68-265 8.49e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 73.46  E-value: 8.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   68 QNHCLQALLREGqVCVDKRTLQEETALMLAVQARQLECVRILLEAGADPDICNKSKETPLYRACEQECVQMVEVLLQRGA 147
Cdd:PHA02874 103 EKDMIKTILDCG-IDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGA 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  148 VVDQRCVRGRSALHAAAERGCVQICVCLLRAGASRDARCAQLNTPAVEAARHGHThTLELLMQNgAAVDLQTSDGYTPLM 227
Cdd:PHA02874 182 YANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRS-AIELLINN-ASINDQDIDGSTPLH 259

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 47550731  228 EACRHG-HTDAVRVLLKHHADTHRASADGLLPLHVASQH 265
Cdd:PHA02874 260 HAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKY 298
Ank_2 pfam12796
Ankyrin repeats (3 copies);
46-118 1.92e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.91  E-value: 1.92e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47550731    46 PSGAEVLDGDDWTPLHEAAYRGQNHCLQALLREGQVcvdKRTLQEETALMLAVQARQLECVRILLEAGADPDI 118
Cdd:pfam12796  20 GADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV---NLKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89
PHA03095 PHA03095
ankyrin-like protein; Provisional
 236-421 2.71e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 71.98  E-value: 2.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  236 DAVRVLLKHHADTHRASADGLLPLHVASQHGHH---RIVSILLPITSRWRLRQS-GISPLHLAAERGH-LRVLELLIGSG 310
Cdd:PHA03095  28 EEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEkvkDIVRLLLEAGADVNAPERcGFTPLHLYLYNATtLDVIKLLIKAG 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  311 CDVNSRlsdersaVFADRRVSPLYCAVAAGRTEVAAALLRAGADPE---LDPFSPL--LLAARQACVRTVELLLRSGAHA 385
Cdd:PHA03095 108 ADVNAK-------DKVGRTPLHVYLSGFNINPKVIRLLLRKGADVNaldLYGMTPLavLLKSRNANVELLRLLIDAGADV 180

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 47550731  386 NTHPPTHNTtfpaaLLHTHQL------EVLRELLEHGCDAHA 421
Cdd:PHA03095 181 YAVDDRFRS-----LLHHHLQsfkpraRIVRELIRAGCDPAA 217
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 58-220 1.01e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 70.02  E-value: 1.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   58 TPLHEAAYRGQNHCLQALLREGQVCVDKRTLQEETALMLAVQARQLECVRILLEAGADPDICNKSKETPLYRACEQECVQ 137
Cdd:PHA02875  70 SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  138 MVEVLLQRGAVVDQRCVRGRSALHAAAERGCVQICVCLLRAGASRD----ARCAQLNTPAVEAARhghTHTLELLMQNGA 213
Cdd:PHA02875 150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDyfgkNGCVAALCYAIENNK---IDIVRLFIKRGA 226


                 ....*..
gi 47550731  214 AVDLQTS 220
Cdd:PHA02875 227 DCNIMFM 233
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 499-539 1.65e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 61.72  E-value: 1.65e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 47550731 499 SPRALVHLCRLQIRHQLGTHRLNSIRSLPLPERLQRYLTSR 539
Cdd:cd03587   1 NPRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 498-536 1.92e-12

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 61.74  E-value: 1.92e-12
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 47550731 498 SSPRALVHLCRLQIRHQLGTHRLNSIRSLPLPERLQRYL 536
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYL 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 72-275 4.66e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.15  E-value: 4.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   72 LQALLREGqVCVDKRTLQEETALMLAVQA-----RQLECVRILLEAGADPDICNKSKETPLYRACEQEC--VQMVEVLLQ 144
Cdd:PHA03100  51 VKILLDNG-ADINSSTKNNSTPLHYLSNIkynltDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKSnsYSIVEYLLD 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  145 RGAVVDQRCVRGRSALHAAAERGCVQICVC--LLRAGASRDARCaqlntpaveaarhghthTLELLMQNGAAVDLQTSDG 222
Cdd:PHA03100 130 NGANVNIKNSDGENLLHLYLESNKIDLKILklLIDKGVDINAKN-----------------RVNYLLSYGVPINIKDVYG 192

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 47550731  223 YTPLMEACRHGHTDAVRVLLKHHADTHRASADGLLPLHVASQHGHHRIVSILL 275
Cdd:PHA03100 193 FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 104-275 5.65e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 67.68  E-value: 5.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  104 ECVRILLEAGADPDICNKSKETPLYRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHAAAERGCVQICVCLLRAGASRD 183
Cdd:PHA02874 105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYAN 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  184 ARCAQLNTPAVEAARHGHTHTLELLMQNGAAVDLQTSDGYTPLMEACRHGHTdaVRVLLKHHADTHRASADGLLPLHVAS 263
Cdd:PHA02874 185 VKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRS--AIELLINNASINDQDIDGSTPLHHAI 262

                        170
                 ....*....|...
gi 47550731  264 QHGHHR-IVSILL 275
Cdd:PHA02874 263 NPPCDIdIIDILL 275
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 196-365 8.30e-12

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 67.97  E-value: 8.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  196 AARHGHTHTLELLMQNGAAVDLQTSDGYTPLMEACRHGHTDAVRVLLKHHADTHRASADGLLPLHVASQHGHHRIVSILL 275
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  276 PITSRWRLRQSGiSPLHLAAERGHLRVLELLIGSGCDVNSRLSDERSAvfadrrvspLYCAVAAGRTEVAAALLRAGADP 355
Cdd:PLN03192 612 HFASISDPHAAG-DLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATA---------LQVAMAEDHVDMVRLLIMNGADV 681

                        170
                 ....*....|....
gi 47550731  356 EL----DPFSPLLL 365
Cdd:PLN03192 682 DKantdDDFSPTEL 695
Ank_2 pfam12796
Ankyrin repeats (3 copies);
291-387 9.13e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.29  E-value: 9.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   291 LHLAAERGHLRVLELLIGSGCDVNSRLSDERsavfadrrvSPLYCAVAAGRTEVAAALLR-AGADPELDPFSPLLLAARQ 369
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGR---------TALHLAAKNGHLEIVKLLLEhADVNLKDNGRTALHYAARS 71

                          90
                  ....*....|....*...
gi 47550731   370 ACVRTVELLLRSGAHANT 387
Cdd:pfam12796  72 GHLEIVKLLLEKGADINV 89
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 94-354 6.58e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 64.30  E-value: 6.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   94 LMLAVQARQLECVRILLEAGADPDICNKSKETPL-----YRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHAAAERgc 168
Cdd:PHA03100  39 LYLAKEARNIDVVKILLDNGADINSSTKNNSTPLhylsnIKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISK-- 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  169 vqicvcllragasrdarcaqlntpaveaaRHGHTHTLELLMQNGAAVDLQTSDGYTPLMEACRHGHTDA--VRVLLKHHA 246
Cdd:PHA03100 117 -----------------------------KSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKLLIDKGV 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  247 DTHRA-SADGLLPLHVasqhghhrivsillPITSRwrlRQSGISPLHLAAERGHLRVLELLIGSGCDVNSRLSDErsavf 325
Cdd:PHA03100 168 DINAKnRVNYLLSYGV--------------PINIK---DVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG----- 225

                        250       260
                 ....*....|....*....|....*....
gi 47550731  326 adrrVSPLYCAVAAGRTEVAAALLRAGAD 354
Cdd:PHA03100 226 ----DTPLHIAILNNNKEIFKLLLNNGPS 250
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 83-229 3.44e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 62.59  E-value: 3.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   83 VDKRTLQeeTALMLAVQARQLECVRILLEAGADPDICNKSKETPLYRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHA 162
Cdd:PHA02878 163 KDRHKGN--TALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHI 240

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47550731  163 AAERgCVQICVC--LLRAGASRDARCAQLNTPAVEAARHGHtHTLELLMQNGAAVDLQTSDGYTPLMEA 229
Cdd:PHA02878 241 SVGY-CKDYDILklLLEHGVDVNAKSYILGLTALHSSIKSE-RKLKLLLEYGADINSLNSYKLTPLSSA 307
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 499-537 4.26e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 54.86  E-value: 4.26e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 47550731   499 SPRALVHLCRLQIRHQLGTHRLNSIRSLPLPERLQRYLT 537
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA03095 PHA03095
ankyrin-like protein; Provisional
 48-249 4.58e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.96  E-value: 4.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   48 GAEVLDGD--DWTPLHeaAY-RGQN---HCLQALLREGqVCVDKRTLQEETALMLAVQARQ--LECVRILLEAGADP--- 116
Cdd:PHA03095 107 GADVNAKDkvGRTPLH--VYlSGFNinpKVIRLLLRKG-ADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVyav 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  117 DICNKS-----KETPLYRACeqecvqMVEVLLQRGAVVDQRCVRGRSALHAAAERG-CVQICVC-LLRAGASRDARCAQL 189
Cdd:PHA03095 184 DDRFRSllhhhLQSFKPRAR------IVRELIRAGCDPAATDMLGNTPLHSMATGSsCKRSLVLpLLIAGISINARNRYG 257

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  190 NTPAVEAARHGHTHTLELLMQNGAAVDLQTSDGYTPLMEACRHGHTDAVRVLLKHHADTH 249
Cdd:PHA03095 258 QTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAE 317
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 98-386 7.54e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 61.62  E-value: 7.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   98 VQARQLECVRILLEAGADPDICNKSKETPLYRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHAAAERGCVQIC----- 172
Cdd:PHA02876 153 IQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIkaiid 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  173 ---------VCLLRAGASRDARCAQL---------------NTPAVEAARHGHTHTL-ELLMQNGAAVDLQTSDGYTPLM 227
Cdd:PHA02876 233 nrsninkndLSLLKAIRNEDLETSLLlydagfsvnsiddckNTPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLY 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  228 EACRHGH-TDAVRVLLKHHADTHRASADGLLPLHVASQHGHHR-IVSILLPITSRWRLRQ-SGISPLHLAAERGHLRVLE 304
Cdd:PHA02876 313 LMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTLDRNKdIVITLLELGANVNARDyCDKTPIHYAAVRNNVVIIN 392

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  305 LLIGSGCDVNSrLSDERSAV--FADRRVSPlYCAVaagrtevaAALLRAGAD---PELDPFSPLLLAARQAC-VRTVELL 378
Cdd:PHA02876 393 TLLDYGADIEA-LSQKIGTAlhFALCGTNP-YMSV--------KTLIDRGANvnsKNKDLSTPLHYACKKNCkLDVIEML 462


                 ....*...
gi 47550731  379 LRSGAHAN 386
Cdd:PHA02876 463 LDNGADVN 470
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 104-262 7.78e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 61.43  E-value: 7.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  104 ECVRILLEAGADPDICNKSK-ETPLYRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHAAAERGCVQICVCLLRAGASR 182
Cdd:PHA02878 148 EITKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  183 DARCAQLNTPA-VEAARHGHTHTLELLMQNGAAVDLQTS-DGYTPLMEACRhgHTDAVRVLLKHHADTHRASADGLLPLH 260
Cdd:PHA02878 228 DARDKCGNTPLhISVGYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLS 305


                 ..
gi 47550731  261 VA 262
Cdd:PHA02878 306 SA 307
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 65-307 9.01e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.13  E-value: 9.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   65 YRGQNHCLQALLREGQVCVDKRTLQEETALMLAVQARQLECVRILLEAGADPDICNKSKETPLYRACEQECVQMVEVLLQ 144
Cdd:PHA02874  10 YSGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLID 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  145 RG---AVVDQRCVrgrsalhaaaERGCVQIcvcLLRAGASRDARCAQLNTPAVEAARHGHTHTLELLMQNGAAVDLQTSD 221
Cdd:PHA02874  90 NGvdtSILPIPCI----------EKDMIKT---ILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  222 GYTPLMEACRHGHTDAVRVLLKHHADTHRASADGLLPLHVASQHGHHRIVSILLPITSRWRLR-QSGISPLHLAAErgHL 300
Cdd:PHA02874 157 GCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKcKNGFTPLHNAII--HN 234


                 ....*...
gi 47550731  301 R-VLELLI 307
Cdd:PHA02874 235 RsAIELLI 242
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 109-254 1.17e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 61.04  E-value: 1.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  109 LLEAGADPDICNKSKETPLYRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHAAAERGCVQICVCLLRagasrdarCAQ 188
Cdd:PLN03192 544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYH--------FAS 615

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47550731  189 LNTPAV------EAARHGHTHTLELLMQNGAAVDLQTSDGYTPLMEACRHGHTDAVRVLLKHHADTHRASAD 254
Cdd:PLN03192 616 ISDPHAagdllcTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 58-315 5.96e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 58.92  E-value: 5.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   58 TPLHEAAYRGQNHCLQALLREG--------------------------QVCVDKRTL--QEETALMLAVQARQLECVRIL 109
Cdd:PHA02876 180 TPIHYAAERGNAKMVNLLLSYGadvniialddlsvlecavdsknidtiKAIIDNRSNinKNDLSLLKAIRNEDLETSLLL 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  110 LEAGADPDICNKSKETPLYRACEQECV-QMVEVLLQRGAVVDQRCVRGRSALHAAAERGC-VQICVCLLRAGASRDARCA 187
Cdd:PHA02876 260 YDAGFSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADR 339

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  188 QLNTPAVEAAR-HGHTHTLELLMQNGAAVDLQTSDGYTPLMEACRHGHTDAVRVLLKHHADTHRASADGLLPLHVAsQHG 266
Cdd:PHA02876 340 LYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFA-LCG 418

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 47550731  267 HHRIVSI--LLPITSRWRLRQSGIS-PLHLAAERG-HLRVLELLIGSGCDVNS 315
Cdd:PHA02876 419 TNPYMSVktLIDRGANVNSKNKDLStPLHYACKKNcKLDVIEMLLDNGADVNA 471
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 106-387 6.17e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 58.14  E-value: 6.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  106 VRILLEAGADPDICNKSKETPLYRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHAAAERGCVQICVcllragasrdar 185
Cdd:PHA03100  18 IKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDV------------ 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  186 caqlntpaVEaarhghthTLELLMQNGAAVDLQTSDGYTPLMEA--CRHGHTDAVRVLLKHHADTHRASADGLLPLHVAS 263
Cdd:PHA03100  86 --------KE--------IVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  264 QHGHH--RIVSILLpitsrwrlrQSGIsplHLAAERghlRVlELLIGSGCDVNSRlsDERSAvfadrrvSPLYCAVAAGR 341
Cdd:PHA03100 150 ESNKIdlKILKLLI---------DKGV---DINAKN---RV-NYLLSYGVPINIK--DVYGF-------TPLHYAVYNNN 204

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 47550731  342 TEVAAALLRAGADPEL---DPFSPLLLAARQACVRTVELLLRSGAHANT 387
Cdd:PHA03100 205 PEFVKYLLDLGANPNLvnkYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 138-275 1.23e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 57.96  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  138 MVEVLLQRGAVVDQRCVRGRSALHAAAERGCVQICVCLLRAGASRDARCAQLNTPAVEAARHGHTHTLELLMQNGAAVDL 217
Cdd:PLN03192 540 LLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISDP 619

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 47550731  218 QTSDGYtpLMEACRHGHTDAVRVLLKHHADTHRASADGLLPLHVASQHGHHRIVSILL 275
Cdd:PLN03192 620 HAAGDL--LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 500-536 1.64e-08

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 50.63  E-value: 1.64e-08
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 47550731 500 PRALVHLCRLQIRHQLGTHRLNSIRSLPLPERLQRYL 536
Cdd:cd03721   3 PRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYL 39
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 224-355 4.07e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 56.17  E-value: 4.07e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731 224 TPLMEACRHGHTDAVRVLLK-HHADTHRASADGLLPLHVASQHGHHRIVSILL---------PITSRWRLrqsGISPLHL 293
Cdd:cd22192  19 SPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMeaapelvnePMTSDLYQ---GETALHI 95

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731 294 AAERGHLRVLELLIGSGCDVNS-RLSderSAVFADRRVS-------PLYCAVAAGRTEVAAALLRAGADP 355
Cdd:cd22192  96 AVVNQNLNLVRELIARGADVVSpRAT---GTFFRPGPKNliyygehPLSFAACVGNEEIVRLLIEHGADI 162
Ank_4 pfam13637
Ankyrin repeats (many copies);
222-275 6.36e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 6.36e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 47550731   222 GYTPLMEACRHGHTDAVRVLLKHHADTHRASADGLLPLHVASQHGHHRIVSILL 275
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 105-421 1.25e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.68  E-value: 1.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  105 CVRILLEAGADPDIC-NKSKETPLYRACEQECVQ-----MVEVLLQRGAVVDQRCVRGRSALHAAAERGCVQICVCLLRA 178
Cdd:PHA02876 121 CIHILKEAISGNDIHyDKINESIEYMKLIKERIQqdellIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSY 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  179 GAsrDARCAQLNTPAV--EAARHGHTHTLELLMQNGAAVDLQTsdgyTPLMEACRhgHTDAVRVLLKHHADTHRASADGL 256
Cdd:PHA02876 201 GA--DVNIIALDDLSVleCAVDSKNIDTIKAIIDNRSNINKND----LSLLKAIR--NEDLETSLLLYDAGFSVNSIDDC 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  257 --LPLHVASQHGH-HRIVSILLPITSRWRLRQ-SGISPLHLAAERGH-LRVLELLIGSGCDVNSrlsdersavfADR-RV 330
Cdd:PHA02876 273 knTPLHHASQAPSlSRLVPKLLERGADVNAKNiKGETPLYLMAKNGYdTENIRTLIMLGADVNA----------ADRlYI 342

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  331 SPLYCAVAAGR-TEVAAALLRAGADPELDPF---SPLLLAARQACVRTVELLLRSGAHANTHPPTHNTTFPAALLHTHQL 406
Cdd:PHA02876 343 TPLHQASTLDRnKDIVITLLELGANVNARDYcdkTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPY 422

                        330
                 ....*....|....*
gi 47550731  407 EVLRELLEHGCDAHA 421
Cdd:PHA02876 423 MSVKTLIDRGANVNS 437
Ank_4 pfam13637
Ankyrin repeats (many copies);
190-242 1.61e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.04  E-value: 1.61e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 47550731   190 NTPAVEAARHGHTHTLELLMQNGAAVDLQTSDGYTPLMEACRHGHTDAVRVLL 242
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 188-315 3.35e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.96  E-value: 3.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  188 QLNTPAVEAARHGHTHTLELLMQNGAAVDLQTSDGYTPLMEACRHGHTDAVRVLLKHHADTHRASADGLLPLHVASQH-G 266
Cdd:PHA02878 167 KGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcK 246

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 47550731  267 HHRIVSILLPITSRWRLRQS--GISPLHLAAERGhlRVLELLIGSGCDVNS 315
Cdd:PHA02878 247 DYDILKLLLEHGVDVNAKSYilGLTALHSSIKSE--RKLKLLLEYGADINS 295
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 499-536 4.57e-07

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 46.53  E-value: 4.57e-07
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 47550731 499 SPRALVHLCRLQIRHQLGTHRLNSIRSLPLPERLQRYL 536
Cdd:cd03718   2 EPLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYL 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 191-402 4.96e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 52.27  E-value: 4.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  191 TPAVEAARHGHTHTLELLMQNGAAVDLQTSDGYTPLMEACRHGHTDAVRVLLKHHADThrasadGLLPLHVASQHGHHRI 270
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDT------SILPIPCIEKDMIKTI 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  271 VSILLPITSRWRLRQSGispLHLAAERGHLRVLELLIGSGCDVNsrLSDersavfaDRRVSPLYCAVAAGRTEVAAALLR 350
Cdd:PHA02874 111 LDCGIDVNIKDAELKTF---LHYAIKKGDLESIKMLFEYGADVN--IED-------DNGCYPIHIAIKHNFFDIIKLLLE 178

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  351 AGADPELDPF---SPLLLAARQACVRTVELLLRSGAH-----ANTHPPTHNttfpaALLH 402
Cdd:PHA02874 179 KGAYANVKDNngeSPLHNAAEYGDYACIKLLIDHGNHimnkcKNGFTPLHN-----AIIH 233
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 498-536 1.00e-06

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 45.40  E-value: 1.00e-06
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 47550731 498 SSPRALVHLCRLQIRHQLGTHRLNSIRSLPLPERLQRYL 536
Cdd:cd03719   1 AEPHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYL 39
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 500-536 1.27e-06

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 45.33  E-value: 1.27e-06
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 47550731 500 PRALVHLCRLQIRHQLGTHRLNSIRSLPLPERLQRYL 536
Cdd:cd03743   3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYL 39
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 499-542 1.70e-06

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 45.21  E-value: 1.70e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 47550731 499 SPRALVHLCRLQIRHQLGTHRL---NSIRSLPLPERLQRYLTSRASD 542
Cdd:cd03731   2 NPRPLKHLCRLKIRKLMGLQKLqqpSSMKKLPLPPALKRYILYKEYD 48
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 498-536 1.93e-06

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 44.72  E-value: 1.93e-06
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 47550731 498 SSPRALVHLCRLQIRHQLGTHRLNSIRSLPLPERLQRYL 536
Cdd:cd03720   1 GNPRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFL 39
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 195-275 4.17e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 4.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  195 EAARHGHTHTLELLMQNGAAVDLQTSDGYTPLMEACRHGHTDAVRVLLKHHADTHRASADGLLPLHVASQHGHHRIVSIL 274
Cdd:PTZ00322  88 QLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167


                 .
gi 47550731  275 L 275
Cdd:PTZ00322 168 S 168
Ank_5 pfam13857
Ankyrin repeats (many copies);
213-262 6.64e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.49  E-value: 6.64e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 47550731   213 AAVDLQTSDGYTPLMEACRHGHTDAVRVLLKHHADTHRASADGLLPLHVA 262
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 498-542 7.32e-06

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 43.68  E-value: 7.32e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 47550731 498 SSPRALVHLCRLQIRHQLGTHRLNS---IRSLPLPERLQRYLTSRASD 542
Cdd:cd03730   1 TNPRSLKHLCRLKIRACMGRLRLRCpvfMSFLPLPNRLKAYILYKEYD 48
Ank_4 pfam13637
Ankyrin repeats (many copies);
92-143 7.47e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.42  E-value: 7.47e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 47550731    92 TALMLAVQARQLECVRILLEAGADPDICNKSKETPLYRACEQECVQMVEVLL 143
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 502-536 1.13e-05

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 42.86  E-value: 1.13e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 47550731 502 ALVHLCRLQIRHQLGTHRLNS---IRSLPLPERLQRYL 536
Cdd:cd03722   5 SLTHLCRLEIRSSLKSERLRSdsfICQLPLPRSLQDYL 42
Ank_5 pfam13857
Ankyrin repeats (many copies);
75-127 1.41e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 1.41e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 47550731    75 LLREGQVCVDKRTLQEETALMLAVQARQLECVRILLEAGADPDICNKSKETPL 127
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 498-539 1.51e-05

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 42.20  E-value: 1.51e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 47550731 498 SSPRALVHLCRLQIRhqlGTHRLNSIRSLPLPERLQRYLTSR 539
Cdd:cd03717   1 TSVRSLQHLCRFVIR---QCTRRDLIDQLPLPRRLKDYLKEY 39
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 49-184 1.58e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.94  E-value: 1.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   49 AEVLDGDDWTPLHEAAYRGQNHCLQALLREGqvC-VDKRTLQEETALMLAVQARQLECVRIL--LEAGADPDICNKSket 125
Cdd:PLN03192 551 PDIGDSKGRTPLHIAASKGYEDCVLVLLKHA--CnVHIRDANGNTALWNAISAKHHKIFRILyhFASISDPHAAGDL--- 625

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 47550731  126 pLYRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHAAAERGCVQICVCLLRAGASRDA 184
Cdd:PLN03192 626 -LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDK 683
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 91-150 1.69e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 47.35  E-value: 1.69e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   91 ETALMLAVQARQLECVRILLEAGADPDICNKSKETPLYRACEQECVQMVEVLLQRGAVVD 150
Cdd:PHA03100 193 FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 501-539 1.72e-05

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 41.63  E-value: 1.72e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 47550731    501 RALVHLCRLQIRHQLGThrlnsIRSLPLPERLQRYLTSR 539
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 223-419 3.67e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.20  E-value: 3.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  223 YTPLMEACRHGHTDAVRVLLKHHADTHRASADGLLPLHVASQHGHH-----RIVSILLPITSRWR-LRQSGISPLHLAA- 295
Cdd:PHA03100  36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNaPDNNGITPLLYAIs 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  296 -ERGHLRVLELLIGSGCDVNSRLSDERSAvfadrrvSPLYCAVAAGRTEVAAALLRAGAD-------------------P 355
Cdd:PHA03100 116 kKSNSYSIVEYLLDNGANVNIKNSDGENL-------LHLYLESNKIDLKILKLLIDKGVDinaknrvnyllsygvpiniK 188

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47550731  356 ELDPFSPLLLAARQACVRTVELLLRSGAHANT-----HPPTHNttfpAALlhTHQLEVLRELLEHGCDA 419
Cdd:PHA03100 189 DVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLvnkygDTPLHI----AIL--NNNKEIFKLLLNNGPSI 251
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 58-133 4.06e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.41  E-value: 4.06e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47550731   58 TPLHEAAYRGQNHCLQALLREGQVCVD-KRTLQEETALMLAVQARQLecVRILLEAGADPDICNKSKETPLYRACEQ 133
Cdd:PHA02878 236 TPLHISVGYCKDYDILKLLLEHGVDVNaKSYILGLTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPLSSAVKQ 310
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 93-177 4.23e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.43  E-value: 4.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   93 ALMLAVQARQLEC------VRILLEAGADPDICNKSKETPLYRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHAAAER 166
Cdd:PTZ00322  79 AHMLTVELCQLAAsgdavgARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEEN 158

                         90
                 ....*....|.
gi 47550731  167 GCVQICVCLLR 177
Cdd:PTZ00322 159 GFREVVQLLSR 169
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 126-421 4.67e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.03  E-value: 4.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  126 PLYRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHAAAERGCVQICVCLLRAGASRDARCAQLNTPavEAARHGHTHTL 205
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAIK--DAFNNRNVEIF 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  206 ELLMQNGAAvDLQTSDgytpLMEACRHGHTDA-----VRVLLKHHADTHRASadgllplhvasqhghhrivsillpitsr 280
Cdd:PHA02878 118 KIILTNRYK-NIQTID----LVYIDKKSKDDIieaeiTKLLLSYGADINMKD---------------------------- 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  281 wrlRQSGISPLHLAAERGHLRVLELLIGSGCDVNSrlsdersavfADR-RVSPLYCAVAAGRTEVAAALLRAGADPELDP 359
Cdd:PHA02878 165 ---RHKGNTALHYATENKDQRLTELLLSYGANVNI----------PDKtNNSPLHHAVKHYNKPIVHILLENGASTDARD 231

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47550731  360 F---SPLLLA-ARQACVRTVELLLRSGAHANTHPPTHNTTfpAALLHTHQLEVLRELLEHGCDAHA 421
Cdd:PHA02878 232 KcgnTPLHISvGYCKDYDILKLLLEHGVDVNAKSYILGLT--ALHSSIKSERKLKLLLEYGADINS 295
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 500-536 6.11e-05

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 40.35  E-value: 6.11e-05
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 47550731 500 PRALVHLCRLQIRHQLGTHRLNSIRSLPLPERLQRYL 536
Cdd:cd03744   3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYL 39
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 498-539 6.41e-05

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 40.54  E-value: 6.41e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 47550731 498 SSPRALVHLCRLQIRHQLGTHRLNSIRSLPLPERLQRYLTSR 539
Cdd:cd03729   1 STPLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSYN 42
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 221-247 8.30e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.93  E-value: 8.30e-05
                          10        20
                  ....*....|....*....|....*..
gi 47550731   221 DGYTPLMEACRHGHTDAVRVLLKHHAD 247
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGAD 27
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 287-314 9.61e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 9.61e-05
                           10        20
                   ....*....|....*....|....*...
gi 47550731    287 GISPLHLAAERGHLRVLELLIGSGCDVN 314
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
Ank_4 pfam13637
Ankyrin repeats (many copies);
289-349 1.08e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 1.08e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47550731   289 SPLHLAAERGHLRVLELLIGSGCDVNSRLSDERsavfadrrvSPLYCAVAAGRTEVAAALL 349
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGE---------TALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
125-176 1.18e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 1.18e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 47550731   125 TPLYRACEQECVQMVEVLLQRGAVVDQRCVRGRSALHAAAERGCVQICVCLL 176
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 233-308 1.20e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.89  E-value: 1.20e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47550731  233 GHTDAVRVLLKHHADTHRASADGLLPLHVASQHGHHRIVSILLPITSRWR-LRQSGISPLHLAAERGHLRVLELLIG 308
Cdd:PTZ00322  93 GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTlLDKDGKTPLELAEENGFREVVQLLSR 169
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 221-249 1.22e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.11  E-value: 1.22e-04
                           10        20
                   ....*....|....*....|....*....
gi 47550731    221 DGYTPLMEACRHGHTDAVRVLLKHHADTH 249
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 498-539 1.52e-04

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 39.20  E-value: 1.52e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 47550731    498 SSPRALVHLCRLQIRHQLGTHrlnSIRSLPLPERLQRYLTSR 539
Cdd:smart00253   5 SNVPSLQHLCRFTIRRCTRTD---QIKTLPLPPKLKDYLSYY 43
Ank_4 pfam13637
Ankyrin repeats (many copies);
156-208 1.67e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 1.67e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 47550731   156 GRSALHAAAERGCVQICVCLLRAGASRDARCAQLNTPAVEAARHGHTHTLELL 208
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 292-380 2.37e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 2.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  292 HLAAErGHLRVLELLIGSGCDVNSRLSDERSavfadrrvsPLYCAVAAGRTEVAAALLRAGADPEL---DPFSPLLLAAR 368
Cdd:PTZ00322  88 QLAAS-GDAVGARILLTGGADPNCRDYDGRT---------PLHIACANGHVQVVRVLLEFGADPTLldkDGKTPLELAEE 157

                         90
                 ....*....|..
gi 47550731  369 QACVRTVELLLR 380
Cdd:PTZ00322 158 NGFREVVQLLSR 169
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 499-536 3.00e-04

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 38.58  E-value: 3.00e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 47550731 499 SPRALVHLCRLQIRHQLGTHRLNSIRSLPLPERLQRYL 536
Cdd:cd03723   2 TPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYL 39
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 502-539 3.77e-04

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 38.17  E-value: 3.77e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 47550731 502 ALVHLCRLQIRHQLGTHRlnsIRSLPLPERLQRYLTSR 539
Cdd:cd03733   5 SLQHLCRMALRRVMTTQQ---VLALPIPKKMKEFLTYR 39
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 91-121 3.81e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.04  E-value: 3.81e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 47550731    91 ETALMLAV-QARQLECVRILLEAGADPDICNK 121
Cdd:pfam00023   3 NTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 287-316 5.16e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 5.16e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 47550731   287 GISPLHLAAER-GHLRVLELLIGSGCDVNSR 316
Cdd:pfam00023   2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNAR 32
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 175-255 5.22e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.96  E-value: 5.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  175 LLRAGASRDARCAQLNTPAVEAARHGHTHTLELLMQNGAAVDLQTSDGYTPLMEACRHGHTDAVRVLLKHHADTHRASAD 254
Cdd:PTZ00322 101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGAN 180


                 .
gi 47550731  255 G 255
Cdd:PTZ00322 181 A 181
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 53-162 5.41e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 42.82  E-value: 5.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  53 DGDDWTPLHEAAYRGQNHclqallrEGQvcvdkrtlqeeTALMLAVQARQLECVRILLEAGADPDICNKSK--------- 123
Cdd:cd22194 122 ENGILDRFINAEYTEEAY-------EGQ-----------TALNIAIERRQGDIVKLLIAKGADVNAHAKGVffnpkykhe 183

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47550731 124 -----ETPLYRACEQECVQMVEVLLQRGA-VVDQRCVRGRSALHA 162
Cdd:cd22194 184 gfyfgETPLALAACTNQPEIVQLLMEKEStDITSQDSRGNTVLHA 228
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 498-538 6.10e-04

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 37.81  E-value: 6.10e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 47550731 498 SSPRALVHLCRLQIRHQLGTHRLNS-IRSLPLPERLQRYLTS 538
Cdd:cd03725   1 SYPPPLKHLCRVFIRLCLRPWPVDVkVKALPLPDRLKWYLLP 42
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 498-539 7.46e-04

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 37.55  E-value: 7.46e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 47550731 498 SSPRALVHLCRLQIRHQLGTHRLNSIRSLPLPERLQRYLTSR 539
Cdd:cd03724   1 ATPSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQYR 42
PHA02946 PHA02946
ankyin-like protein; Provisional
 94-259 7.97e-04

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.96  E-value: 7.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   94 LMLAVQARQLECVRILLEAGADPDICNKSKETPLY--RACEQECVQMVEVLLQRGAVVDqrcvrgrsalHAAAERGCVQI 171
Cdd:PHA02946  76 LHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYylSGTDDEVIERINLLVQYGAKIN----------NSVDEEGCGPL 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  172 CVCLlragASRDARCAQLNTPAVEA-------ARHGHTH---------TLELLMQNGAAVDLQTSDGYTPLMEACRH--G 233
Cdd:PHA02946 146 LACT----DPSERVFKKIMSIGFEArivdkfgKNHIHRHlmsdnpkasTISWMMKLGISPSKPDHDGNTPLHIVCSKtvK 221

                        170       180
                 ....*....|....*....|....*.
gi 47550731  234 HTDAVRVLLKhHADTHRASADGLLPL 259
Cdd:PHA02946 222 NVDIINLLLP-STDVNKQNKFGDSPL 246
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 502-539 9.35e-04

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 37.18  E-value: 9.35e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 47550731 502 ALVHLCRLQIRHQLGTHRlnsIRSLPLPERLQRYLTSR 539
Cdd:cd03745   5 SLRHLCRKALRHFLTTYQ---VLALPIPKKMKEFLTYR 39
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 287-314 1.18e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.47  E-value: 1.18e-03
                          10        20
                  ....*....|....*....|....*...
gi 47550731   287 GISPLHLAAERGHLRVLELLIGSGCDVN 314
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 221-247 1.41e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.50  E-value: 1.41e-03
                          10        20
                  ....*....|....*....|....*...
gi 47550731   221 DGYTPLMEAC-RHGHTDAVRVLLKHHAD 247
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGAD 28
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 48-213 1.62e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.20  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731   48 GAEVLDGDDW--TPLHEAAYRGQNHCLQALLREGQVCVDKRTLQEETALMLAVQARQLECVRILLEAGADPDICNKSKET 125
Cdd:PHA02876 331 GADVNAADRLyiTPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGT 410

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  126 PLYRA-CEQECVQMVEVLLQRGAVVDQRCVRGRSALHAAAERGC-VQICVCLLRAGASRDARCAQLNTPAVEAArhGHTH 203
Cdd:PHA02876 411 ALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNCkLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHG 488

                        170
                 ....*....|
gi 47550731  204 TLELLMQNGA 213
Cdd:PHA02876 489 IVNILLHYGA 498
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 499-542 1.76e-03

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 36.36  E-value: 1.76e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 47550731 499 SPRALVHLCRLQIRHQLGTHRLNSIRSLPLPERLQRYLTSRASD 542
Cdd:cd03726   2 QPRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHKFDD 45
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 92-118 1.90e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 1.90e-03
                           10        20
                   ....*....|....*....|....*..
gi 47550731     92 TALMLAVQARQLECVRILLEAGADPDI 118
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 75-143 3.40e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.27  E-value: 3.40e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47550731   75 LLREGQVCVDKRTLQEETALMLAVQARQLECVRILLEAGADPDICNKSKETPLYRACEQECVQMVEVLL 143
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
Ank_4 pfam13637
Ankyrin repeats (many copies);
57-110 3.67e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 3.67e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 47550731    57 WTPLHEAAYRGQNHCLQALLrEGQVCVDKRTLQEETALMLAVQARQLECVRILL 110
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLL-EKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 288-418 5.69e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 39.18  E-value: 5.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  288 ISPLHLAAERGHLRVLELLIGSGCDVNSrlsdersavFADRRVSPLYCAVAAGRTEVAAALLRAGADPELDPFsplllaa 367
Cdd:PHA02874  36 TTPLIDAIRSGDAKIVELFIKHGADINH---------INTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILPI------- 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 47550731  368 rqACVR--TVELLLRSGAHANTHpPTHNTTFPAALLHTHQLEVLRELLEHGCD 418
Cdd:PHA02874 100 --PCIEkdMIKTILDCGIDVNIK-DAELKTFLHYAIKKGDLESIKMLFEYGAD 149
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 288-422 6.22e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 39.26  E-value: 6.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  288 ISPLHLAAERGHLRVLELLIGSGCDVNSRLSDERSA-VFADRRVSPLYCAVaagrtEVAAALLRAGADPEL---DPFSPL 363
Cdd:PHA03100  36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPlHYLSNIKYNLTDVK-----EIVKLLLEYGANVNApdnNGITPL 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47550731  364 LLAA--RQACVRTVELLLRSGAHANTHPPTHNTTFPAALLHTH-QLEVLRELLEHGCDAHAC 422
Cdd:PHA03100 111 LYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKiDLKILKLLIDKGVDINAK 172
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 89-243 7.72e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 39.01  E-value: 7.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731  89 QEETALMLAVQARQLECVRILLEAGAD------PDICNKSK--------ETPLYRACEQECVQMVEVLLQ---RGAVVDQ 151
Cdd:cd22193  75 EGQTALHIAIERRQGDIVALLVENGADvhahakGRFFQPKYqgegfyfgELPLSLAACTNQPDIVQYLLEnehQPADIEA 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550731 152 RCVRGRSALHAaaergCVQIcvcllrAGASRDarcaqlNTPAVeaarhghTHTLELLMQNGA----AVDLQT---SDGYT 224
Cdd:cd22193 155 QDSRGNTVLHA-----LVTV------ADNTKE------NTKFV-------TRMYDMILIRGAklcpTVELEEirnNDGLT 210

                       170
                ....*....|....*....
gi 47550731 225 PLMEACRHGHTDAVRVLLK 243
Cdd:cd22193 211 PLQLAAKMGKIEILKYILQ 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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