NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|109033138|ref|XP_001107824|]
View 

neuromodulin isoform X2 [Macaca mulatta]

Protein Classification

IQ calmodulin-binding motif-containing protein; leucine-rich repeat and IQ domain-containing protein( domain architecture ID 12107677)

IQ calmodulin-binding motif-containing protein may be involved in cooperative interactions with calmodulins or calmodulin-like proteins| leucine-rich repeat and IQ domain-containing protein may bind calmodulin and participate in protein-protein interactions

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Neuromodulin pfam06614
Neuromodulin; This family consists of several neuromodulin (Axonal membrane protein GAP-43) ...
 67-238 3.76e-42

Neuromodulin; This family consists of several neuromodulin (Axonal membrane protein GAP-43) sequences and is found in conjunction with pfam00612. GAP-43 is a neuronal calmodulin-binding phosphoprotein that is concentrated in growth cones and pre-synaptic terminals.


:

Pssm-ID: 461961 [Multi-domain]  Cd Length: 175  Bit Score: 141.45  E-value: 3.76e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109033138   67 NKKDEAPVADGVEKK-GEGTTATEAAPATGSKPDEPGKAGETPSEEKKGEG--DAATEQAAPQAPASSEEKAGSAETESA 143
Cdd:pfam06614   1 KKKDEAPAADGVEKKeSEAPTATEAAPAAGAKPDEAGKAGDTPSEEKKGEGaaDAASEQAAPQAPASSEEKAGSAETESA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109033138  144 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
Cdd:pfam06614  81 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETAESSQAEEKTEAVDETKPKESARQ 160

                         170
                  ....*....|....*
gi 109033138  224 DEGKEEEPEADQEHA 238
Cdd:pfam06614 161 DEGKEEESEADQEHA 175
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 30-52 2.26e-05

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


:

Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 40.00  E-value: 2.26e-05
                           10        20
                   ....*....|....*....|...
gi 109033138    30 KAHKAATKIQASFRGHITRKKLK 52
Cdd:smart00015   1 RLTRAAIIIQAAWRGYLARKRYK 23
Neuromodulin_N pfam10580
Gap junction protein N-terminal region;
2-31 1.73e-03

Gap junction protein N-terminal region;


:

Pssm-ID: 431370 [Multi-domain]  Cd Length: 31  Bit Score: 34.96  E-value: 1.73e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 109033138    2 LCCMRRTKQVEKNDE-DQKIEQDGIKPEDKA 31
Cdd:pfam10580   1 LCCVRASAKVEKNDEaDQKIEQDGNKPEDKA 31
 
Name Accession Description Interval E-value
Neuromodulin pfam06614
Neuromodulin; This family consists of several neuromodulin (Axonal membrane protein GAP-43) ...
 67-238 3.76e-42

Neuromodulin; This family consists of several neuromodulin (Axonal membrane protein GAP-43) sequences and is found in conjunction with pfam00612. GAP-43 is a neuronal calmodulin-binding phosphoprotein that is concentrated in growth cones and pre-synaptic terminals.


Pssm-ID: 461961 [Multi-domain]  Cd Length: 175  Bit Score: 141.45  E-value: 3.76e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109033138   67 NKKDEAPVADGVEKK-GEGTTATEAAPATGSKPDEPGKAGETPSEEKKGEG--DAATEQAAPQAPASSEEKAGSAETESA 143
Cdd:pfam06614   1 KKKDEAPAADGVEKKeSEAPTATEAAPAAGAKPDEAGKAGDTPSEEKKGEGaaDAASEQAAPQAPASSEEKAGSAETESA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109033138  144 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
Cdd:pfam06614  81 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETAESSQAEEKTEAVDETKPKESARQ 160

                         170
                  ....*....|....*
gi 109033138  224 DEGKEEEPEADQEHA 238
Cdd:pfam06614 161 DEGKEEESEADQEHA 175
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 30-52 2.26e-05

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 40.00  E-value: 2.26e-05
                           10        20
                   ....*....|....*....|...
gi 109033138    30 KAHKAATKIQASFRGHITRKKLK 52
Cdd:smart00015   1 RLTRAAIIIQAAWRGYLARKRYK 23
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
 32-52 4.69e-05

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 459869  Cd Length: 21  Bit Score: 39.22  E-value: 4.69e-05
                          10        20
                  ....*....|....*....|.
gi 109033138   32 HKAATKIQASFRGHITRKKLK 52
Cdd:pfam00612   1 RKAAIKIQAAWRGYLARKRYK 21
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 28-56 1.73e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 37.91  E-value: 1.73e-04
                         10        20
                 ....*....|....*....|....*....
gi 109033138  28 EDKAHKAATKIQASFRGHITRKKLKGEKK 56
Cdd:cd23767    5 LQRMNRAATLIQALWRGYKVRKELKKKKK 33
Neuromodulin_N pfam10580
Gap junction protein N-terminal region;
2-31 1.73e-03

Gap junction protein N-terminal region;


Pssm-ID: 431370 [Multi-domain]  Cd Length: 31  Bit Score: 34.96  E-value: 1.73e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 109033138    2 LCCMRRTKQVEKNDE-DQKIEQDGIKPEDKA 31
Cdd:pfam10580   1 LCCVRASAKVEKNDEaDQKIEQDGNKPEDKA 31
 
Name Accession Description Interval E-value
Neuromodulin pfam06614
Neuromodulin; This family consists of several neuromodulin (Axonal membrane protein GAP-43) ...
 67-238 3.76e-42

Neuromodulin; This family consists of several neuromodulin (Axonal membrane protein GAP-43) sequences and is found in conjunction with pfam00612. GAP-43 is a neuronal calmodulin-binding phosphoprotein that is concentrated in growth cones and pre-synaptic terminals.


Pssm-ID: 461961 [Multi-domain]  Cd Length: 175  Bit Score: 141.45  E-value: 3.76e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109033138   67 NKKDEAPVADGVEKK-GEGTTATEAAPATGSKPDEPGKAGETPSEEKKGEG--DAATEQAAPQAPASSEEKAGSAETESA 143
Cdd:pfam06614   1 KKKDEAPAADGVEKKeSEAPTATEAAPAAGAKPDEAGKAGDTPSEEKKGEGaaDAASEQAAPQAPASSEEKAGSAETESA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109033138  144 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
Cdd:pfam06614  81 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETAESSQAEEKTEAVDETKPKESARQ 160

                         170
                  ....*....|....*
gi 109033138  224 DEGKEEEPEADQEHA 238
Cdd:pfam06614 161 DEGKEEESEADQEHA 175
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 30-52 2.26e-05

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 40.00  E-value: 2.26e-05
                           10        20
                   ....*....|....*....|...
gi 109033138    30 KAHKAATKIQASFRGHITRKKLK 52
Cdd:smart00015   1 RLTRAAIIIQAAWRGYLARKRYK 23
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
 32-52 4.69e-05

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 459869  Cd Length: 21  Bit Score: 39.22  E-value: 4.69e-05
                          10        20
                  ....*....|....*....|.
gi 109033138   32 HKAATKIQASFRGHITRKKLK 52
Cdd:pfam00612   1 RKAAIKIQAAWRGYLARKRYK 21
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 28-56 1.73e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 37.91  E-value: 1.73e-04
                         10        20
                 ....*....|....*....|....*....
gi 109033138  28 EDKAHKAATKIQASFRGHITRKKLKGEKK 56
Cdd:cd23767    5 LQRMNRAATLIQALWRGYKVRKELKKKKK 33
Adgb_C_mid-like cd22307
C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted ...
 14-52 3.71e-04

C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif; Androglobin (Adgb, also known as Calpain-7-like protein, CAPN7L) is a large multidomain protein consisting of an N-terminal peptidase C2 family calpain-like domain, an IQ calmodulin-binding motif, and an internal, circularly permuted globin domain. The canonical secondary structure of hemoglobins is an 3-over-3 alpha-helical sandwich structure, where the eight alpha-helical segments are conventionally labeled, A-H, according to their sequential order; Adgbs differ from this in having helices C-H followed by A-B. Adgbs and other phylogenetically ancient globins, such as neuroglobins and globin X, form hexacoordinated heme iron complexes. Globins contain various highly conserved residues of the heme pocket: including a Phe in the interhelical position CD1 (Phe CD1, first position in the loop between the helices C and D) that is packed against the heme, a His at the 7th position of the E-helix (His E7) that binds the heme iron distally, and a His at the 8th position of the F-helix (His F8) that binds the heme iron proximally. Unlike other hexacoordinated globins, Adgbs have an E7 Gln; their hexacoordination scheme is [Gln]-Fe-[His]. In mammals, Adgb is mainly expressed in the testes and may play an important role in spermatogenesis. Arthropod Adgbs have degenerate globin domains (DOI:10.3389/fgene.2020.00858). This model spans the permuted globin domain, the IQ motif, and a conserved region of about 200 amino acid residues located C-terminal to the globin domain; it does not include the N-terminal protease domain or the large uncharacterized C-terminal domain of approximately 500 residues.


Pssm-ID: 412094  Cd Length: 416  Bit Score: 41.00  E-value: 3.71e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 109033138  14 NDEDQKIEQDGI--KPEDKAHKAATKIQASFRGHITRKKLK 52
Cdd:cd22307  127 REIVEPDECDCRtrEPTIEEHEAATKIQAFFRGTLVRKLLK 167
Neuromodulin_N pfam10580
Gap junction protein N-terminal region;
2-31 1.73e-03

Gap junction protein N-terminal region;


Pssm-ID: 431370 [Multi-domain]  Cd Length: 31  Bit Score: 34.96  E-value: 1.73e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 109033138    2 LCCMRRTKQVEKNDE-DQKIEQDGIKPEDKA 31
Cdd:pfam10580   1 LCCVRASAKVEKNDEaDQKIEQDGNKPEDKA 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH