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Conserved domains on  [gi|528491728|ref|XP_005155621|]
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very low-density lipoprotein receptor isoform X5 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
234-269 5.69e-13

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 63.42  E-value: 5.69e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 528491728  234 KCSPSEMQCGSGECIHRKWRCDGDPDCKDGSDEKNC 269
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 564-604 1.30e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 62.56  E-value: 1.30e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 528491728  564 GFLYWSDWGEPAKIEKSGMNGNDRQVLVETDIQWPNGITLD 604
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 588-630 1.50e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.54  E-value: 1.50e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 528491728   588 QVLVETDIQWPNGITLDLIKGRLYWVDSKLHMLCSVDLNGDNR 630
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 29-63 4.07e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 4.07e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 528491728  29 CEQSQFQCGNGRCIPSVWQCDGDMDCSDGSDETSC 63
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 504-541 1.12e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 1.12e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 528491728   504 VIDDVQMPVGIAVDWIYKNIYWSDLGSKSITVANFNGT 541
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
149-184 1.76e-10

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.49  E-value: 1.76e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 528491728  149 TCAPLEFTCSSGRCVSRKFVCNGEDDCGDGSDEQDC 184
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 67-99 7.66e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 7.66e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 528491728    67 TCAEVDFVCRSGQCIPKRWQCDGEPDCEDGSDE 99
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 651-691 1.30e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.09  E-value: 1.30e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 528491728  651 DRVFWTDGENEAIYGANKFTGSDV-TLLASNLNEPQDIIVYH 691
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
272-308 2.20e-09

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 2.20e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 528491728  272 RNCRPDQFKCDDGSCIHGSRQCNGFRDCVDGTDEVNC 308
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
107-145 1.20e-07

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 1.20e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 528491728  107 RTCRVNEFSCGvgSTQCIPVFWKCDGEKDCDNGEDEINC 145
Cdd:pfam00057   1 STCSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 316-346 8.78e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 8.78e-07
                         10        20        30
                 ....*....|....*....|....*....|.
gi 528491728 316 SSDQFKCRSGECIEMSKVCNKVRDCPDWSDE 346
Cdd:cd00112    2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
392-426 2.06e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.06e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 528491728   392 DVNECLNPGICSQ--ICINLKGGYKCECHNGYQMDPT 426
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 356-390 2.38e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.84  E-value: 2.38e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 528491728  356 CLINNGGCSHICRDLTIGFECDCTPGLQLI-DRKTC 390
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 479-570 1.78e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14962:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 271  Bit Score: 44.12  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528491728 479 IFWADLGQKAIFstVLDKQDESHKKVIDDV----QMPVGIAVDwIYKNIYWSDLGSKSITVANFNGTKKKVLFNSGL-KE 553
Cdd:cd14962   25 IYVADTGRGAVF--VFDLPNGKVFVIGNAGpnrfVSPIGVAID-ANGNLYVSDAELGKVFVFDRDGKFLRAIGAGALfKR 101

                         90
                 ....*....|....*..
gi 528491728 554 PASIAVDPLSGFLYWSD 570
Cdd:cd14962  102 PTGIAVDPAGKRLYVVD 118
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 708-745 7.50e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.61  E-value: 7.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 528491728  708 NGGCSFMCLPAPQinkhspKYTCVCPEGQTLASDGLRC 745
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 457-495 8.87e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 34.88  E-value: 8.87e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528491728   457 YTQIVEQLRNTVALDADFIQQMIFWADLGQKAIFSTVLD 495
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Name Accession Description Interval E-value
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
234-269 5.69e-13

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 63.42  E-value: 5.69e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 528491728  234 KCSPSEMQCGSGECIHRKWRCDGDPDCKDGSDEKNC 269
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 564-604 1.30e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 62.56  E-value: 1.30e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 528491728  564 GFLYWSDWGEPAKIEKSGMNGNDRQVLVETDIQWPNGITLD 604
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 235-269 1.28e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 1.28e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 528491728 235 CSPSEMQCGSGECIHRKWRCDGDPDCKDGSDEKNC 269
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 588-630 1.50e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.54  E-value: 1.50e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 528491728   588 QVLVETDIQWPNGITLDLIKGRLYWVDSKLHMLCSVDLNGDNR 630
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 29-63 4.07e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 4.07e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 528491728  29 CEQSQFQCGNGRCIPSVWQCDGDMDCSDGSDETSC 63
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 504-541 1.12e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 1.12e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 528491728   504 VIDDVQMPVGIAVDWIYKNIYWSDLGSKSITVANFNGT 541
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 544-587 1.16e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 1.16e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 528491728   544 KVLFNSGLKEPASIAVDPLSGFLYWSDWGEPaKIEKSGMNGNDR 587
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 28-60 1.75e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.49  E-value: 1.75e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 528491728    28 ECEQSQFQCGNGRCIPSVWQCDGDMDCSDGSDE 60
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
149-184 1.76e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.49  E-value: 1.76e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 528491728  149 TCAPLEFTCSSGRCVSRKFVCNGEDDCGDGSDEQDC 184
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 150-184 2.02e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.06  E-value: 2.02e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 528491728 150 CAPLEFTCSSGRCVSRKFVCNGEDDCGDGSDEQDC 184
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 67-99 7.66e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 7.66e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 528491728    67 TCAEVDFVCRSGQCIPKRWQCDGEPDCEDGSDE 99
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
29-63 9.37e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.56  E-value: 9.37e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 528491728   29 CEQSQFQCGNGRCIPSVWQCDGDMDCSDGSDETSC 63
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 234-266 1.08e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 1.08e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 528491728   234 KCSPSEMQCGSGECIHRKWRCDGDPDCKDGSDE 266
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 651-691 1.30e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.09  E-value: 1.30e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 528491728  651 DRVFWTDGENEAIYGANKFTGSDV-TLLASNLNEPQDIIVYH 691
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
66-99 2.05e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 2.05e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 528491728   66 KTCAEVDFVCRSGQCIPKRWQCDGEPDCEDGSDE 99
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
272-308 2.20e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 2.20e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 528491728  272 RNCRPDQFKCDDGSCIHGSRQCNGFRDCVDGTDEVNC 308
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 68-99 2.92e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 2.92e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 528491728  68 CAEVDFVCRSGQCIPKRWQCDGEPDCEDGSDE 99
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 149-181 5.63e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 5.63e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 528491728   149 TCAPLEFTCSSGRCVSRKFVCNGEDDCGDGSDE 181
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 274-308 6.50e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 6.50e-09
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 528491728 274 CRPDQFKCDDGSCIHGSRQCNGFRDCVDGTDEVNC 308
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
107-145 1.20e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 1.20e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 528491728  107 RTCRVNEFSCGvgSTQCIPVFWKCDGEKDCDNGEDEINC 145
Cdd:pfam00057   1 STCSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 109-145 1.74e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.97  E-value: 1.74e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 528491728 109 CRVNEFSCGVGstQCIPVFWKCDGEKDCDNGEDEINC 145
Cdd:cd00112    1 CPPNEFRCANG--RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 274-305 3.83e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.86  E-value: 3.83e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 528491728   274 CRPDQFKCDDGSCIHGSRQCNGFRDCVDGTDE 305
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 316-346 8.78e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 8.78e-07
                         10        20        30
                 ....*....|....*....|....*....|.
gi 528491728 316 SSDQFKCRSGECIEMSKVCNKVRDCPDWSDE 346
Cdd:cd00112    2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 316-346 1.03e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 1.03e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 528491728   316 SSDQFKCRSGECIEMSKVCNKVRDCPDWSDE 346
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
479-614 1.11e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.85  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528491728 479 IFWADLGQKAIfsTVLDKQDESHKKVIDDVQMPVGIAVDWIYKNIYWSDLGSKSITVanFNGTKKKVL--FNSGlKEPAS 556
Cdd:COG3391   82 LYVANSGSGRV--SVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVatIPVG-AGPHG 156

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528491728 557 IAVDPLSGFLYWSDWGEP--AKIEkSGMNGNDRQVLVETDI-QWPNGITLDLIKGRLYWVD 614
Cdd:COG3391  157 IAVDPDGKRLYVANSGSNtvSVIV-SVIDTATGKVVATIPVgGGPVGVAVSPDGRRLYVAN 216
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 108-142 6.83e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.39  E-value: 6.83e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 528491728   108 TCRVNEFSCGVGstQCIPVFWKCDGEKDCDNGEDE 142
Cdd:smart00192   1 TCPPGEFQCDNG--RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
316-346 1.00e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.01  E-value: 1.00e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 528491728  316 SSDQFKCRSGECIEMSKVCNKVRDCPDWSDE 346
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
392-426 2.06e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.06e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 528491728   392 DVNECLNPGICSQ--ICINLKGGYKCECHNGYQMDPT 426
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 356-390 2.38e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.84  E-value: 2.38e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 528491728  356 CLINNGGCSHICRDLTIGFECDCTPGLQLI-DRKTC 390
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 608-650 2.66e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.76  E-value: 2.66e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 528491728  608 GRLYWVDSKLH-MLCSVDLNGDNRRKVLQspDYLAHPFALTVFE 650
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSDRKTLFT--DDLQHPNAIAVDP 42
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 392-422 1.12e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.12e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 528491728 392 DVNECLNPGICS--QICINLKGGYKCECHNGYQ 422
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 479-570 1.78e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 44.12  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528491728 479 IFWADLGQKAIFstVLDKQDESHKKVIDDV----QMPVGIAVDwIYKNIYWSDLGSKSITVANFNGTKKKVLFNSGL-KE 553
Cdd:cd14962   25 IYVADTGRGAVF--VFDLPNGKVFVIGNAGpnrfVSPIGVAID-ANGNLYVSDAELGKVFVFDRDGKFLRAIGAGALfKR 101

                         90
                 ....*....|....*..
gi 528491728 554 PASIAVDPLSGFLYWSD 570
Cdd:cd14962  102 PTGIAVDPAGKRLYVVD 118
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 397-430 7.07e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.61  E-value: 7.07e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 528491728  397 LNPGICSQICINLKGGYKCECHNGYQMDPTTGVC 430
Cdd:pfam14670   3 VNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 708-745 7.50e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.61  E-value: 7.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 528491728  708 NGGCSFMCLPAPQinkhspKYTCVCPEGQTLASDGLRC 745
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 479-518 2.05e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 36.75  E-value: 2.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 528491728  479 IFWADLGQKA-IFSTVLDKQDEsHKKVIDDVQMPVGIAVDW 518
Cdd:pfam00058   3 LYWTDSSLRAsISSADLNGSDR-KTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 457-495 8.87e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 34.88  E-value: 8.87e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528491728   457 YTQIVEQLRNTVALDADFIQQMIFWADLGQKAIFSTVLD 495
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Name Accession Description Interval E-value
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
234-269 5.69e-13

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 63.42  E-value: 5.69e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 528491728  234 KCSPSEMQCGSGECIHRKWRCDGDPDCKDGSDEKNC 269
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 564-604 1.30e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 62.56  E-value: 1.30e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 528491728  564 GFLYWSDWGEPAKIEKSGMNGNDRQVLVETDIQWPNGITLD 604
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 235-269 1.28e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 1.28e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 528491728 235 CSPSEMQCGSGECIHRKWRCDGDPDCKDGSDEKNC 269
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 588-630 1.50e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.54  E-value: 1.50e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 528491728   588 QVLVETDIQWPNGITLDLIKGRLYWVDSKLHMLCSVDLNGDNR 630
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 29-63 4.07e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 4.07e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 528491728  29 CEQSQFQCGNGRCIPSVWQCDGDMDCSDGSDETSC 63
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 504-541 1.12e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 1.12e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 528491728   504 VIDDVQMPVGIAVDWIYKNIYWSDLGSKSITVANFNGT 541
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 544-587 1.16e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 1.16e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 528491728   544 KVLFNSGLKEPASIAVDPLSGFLYWSDWGEPaKIEKSGMNGNDR 587
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 28-60 1.75e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.49  E-value: 1.75e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 528491728    28 ECEQSQFQCGNGRCIPSVWQCDGDMDCSDGSDE 60
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
149-184 1.76e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.49  E-value: 1.76e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 528491728  149 TCAPLEFTCSSGRCVSRKFVCNGEDDCGDGSDEQDC 184
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 150-184 2.02e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.06  E-value: 2.02e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 528491728 150 CAPLEFTCSSGRCVSRKFVCNGEDDCGDGSDEQDC 184
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 67-99 7.66e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 7.66e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 528491728    67 TCAEVDFVCRSGQCIPKRWQCDGEPDCEDGSDE 99
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
29-63 9.37e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.56  E-value: 9.37e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 528491728   29 CEQSQFQCGNGRCIPSVWQCDGDMDCSDGSDETSC 63
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 234-266 1.08e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 1.08e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 528491728   234 KCSPSEMQCGSGECIHRKWRCDGDPDCKDGSDE 266
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 651-691 1.30e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.09  E-value: 1.30e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 528491728  651 DRVFWTDGENEAIYGANKFTGSDV-TLLASNLNEPQDIIVYH 691
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
66-99 2.05e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 2.05e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 528491728   66 KTCAEVDFVCRSGQCIPKRWQCDGEPDCEDGSDE 99
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
272-308 2.20e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 2.20e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 528491728  272 RNCRPDQFKCDDGSCIHGSRQCNGFRDCVDGTDEVNC 308
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 68-99 2.92e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 2.92e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 528491728  68 CAEVDFVCRSGQCIPKRWQCDGEPDCEDGSDE 99
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 149-181 5.63e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 5.63e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 528491728   149 TCAPLEFTCSSGRCVSRKFVCNGEDDCGDGSDE 181
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 274-308 6.50e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 6.50e-09
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 528491728 274 CRPDQFKCDDGSCIHGSRQCNGFRDCVDGTDEVNC 308
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
107-145 1.20e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 1.20e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 528491728  107 RTCRVNEFSCGvgSTQCIPVFWKCDGEKDCDNGEDEINC 145
Cdd:pfam00057   1 STCSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 479-664 1.25e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 53.83  E-value: 1.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528491728 479 IFWADLGQKAIfsTVLDKQDE-----SHKKVIDDVQMPVGIAVDwiYKNIYWSDLGSKSITVANFNGTKKKVLFNSG--- 550
Cdd:cd14963   69 IYVADLYNGRI--QVFDPDGKflkyfPEKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLEFGKPGsep 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528491728 551 --LKEPASIAVDPlSGFLYWSDW-----------GEPAKIEKSGMNGNDRQVLvetdiqwPNGITLDLiKGRLYWVDSKL 617
Cdd:cd14963  145 geLSYPNGIAVDE-DGNIYVADSgngriqvfdknGKFIKELNGSPDGKSGFVN-------PRGIAVDP-DGNLYVVDNLS 215

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528491728 618 HMLCSVDLNGDNRRKVLQS---PDYLAHPFALTVFED-RVFWTDGENEAIY 664
Cdd:cd14963  216 HRVYVFDEQGKELFTFGGRgkdDGQFNLPNGLFIDDDgRLYVTDRENNRVA 266
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 522-561 1.73e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.92  E-value: 1.73e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 528491728  522 NIYWSDLGSK-SITVANFNGTKKKVLFNSGLKEPASIAVDP 561
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 109-145 1.74e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.97  E-value: 1.74e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 528491728 109 CRVNEFSCGVGstQCIPVFWKCDGEKDCDNGEDEINC 145
Cdd:cd00112    1 CPPNEFRCANG--RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 274-305 3.83e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.86  E-value: 3.83e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 528491728   274 CRPDQFKCDDGSCIHGSRQCNGFRDCVDGTDE 305
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 316-346 8.78e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 8.78e-07
                         10        20        30
                 ....*....|....*....|....*....|.
gi 528491728 316 SSDQFKCRSGECIEMSKVCNKVRDCPDWSDE 346
Cdd:cd00112    2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 316-346 1.03e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 1.03e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 528491728   316 SSDQFKCRSGECIEMSKVCNKVRDCPDWSDE 346
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
479-614 1.11e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.85  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528491728 479 IFWADLGQKAIfsTVLDKQDESHKKVIDDVQMPVGIAVDWIYKNIYWSDLGSKSITVanFNGTKKKVL--FNSGlKEPAS 556
Cdd:COG3391   82 LYVANSGSGRV--SVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVatIPVG-AGPHG 156

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528491728 557 IAVDPLSGFLYWSDWGEP--AKIEkSGMNGNDRQVLVETDI-QWPNGITLDLIKGRLYWVD 614
Cdd:COG3391  157 IAVDPDGKRLYVANSGSNtvSVIV-SVIDTATGKVVATIPVgGGPVGVAVSPDGRRLYVAN 216
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 108-142 6.83e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.39  E-value: 6.83e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 528491728   108 TCRVNEFSCGVGstQCIPVFWKCDGEKDCDNGEDE 142
Cdd:smart00192   1 TCPPGEFQCDNG--RCIPSSWVCDGVDDCGDGSDE 33
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 503-660 6.89e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 48.74  E-value: 6.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528491728 503 KVIDDVQMPVGIAVDWIYKnIYWSDLGSKSITVANFNGTKKKVLFNSG---LKEPASIAVDPlSGFLYWSDwGEPAKIEK 579
Cdd:cd14962    6 RPKEALTRPYGVAADGRGR-IYVADTGRGAVFVFDLPNGKVFVIGNAGpnrFVSPIGVAIDA-NGNLYVSD-AELGKVFV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528491728 580 SGMNGNDRQVLVETDIQW-PNGITLDLIKGRLYWVDSKLHMLCSVDLNGDNRRKVLQS---PDYLAHPFALTVF-EDRVF 654
Cdd:cd14962   83 FDRDGKFLRAIGAGALFKrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRgsgPGEFNLPTDLAVDrDGNLY 162


                 ....*.
gi 528491728 655 WTDGEN 660
Cdd:cd14962  163 VTDTMN 168
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
316-346 1.00e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.01  E-value: 1.00e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 528491728  316 SSDQFKCRSGECIEMSKVCNKVRDCPDWSDE 346
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
392-426 2.06e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.06e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 528491728   392 DVNECLNPGICSQ--ICINLKGGYKCECHNGYQMDPT 426
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 356-390 2.38e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.84  E-value: 2.38e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 528491728  356 CLINNGGCSHICRDLTIGFECDCTPGLQLI-DRKTC 390
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 608-650 2.66e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.76  E-value: 2.66e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 528491728  608 GRLYWVDSKLH-MLCSVDLNGDNRRKVLQspDYLAHPFALTVFE 650
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSDRKTLFT--DDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 509-689 5.48e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 45.77  E-value: 5.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528491728 509 QMPVGIAVDwIYKNIYWSDLGSKSITVANFNGTKKKVLFNSG-----LKEPASIAVDPlSGFLYWSDWGEpAKIEKSGMN 583
Cdd:cd05819    8 NNPQGIAVD-SSGNIYVADTGNNRIQVFDPDGNFITSFGSFGsgdgqFNEPAGVAVDS-DGNLYVADTGN-HRIQKFDPD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528491728 584 GNDRQVLVETDIQ-----WPNGITLDLiKGRLYWVDSKLHMLCSVDLNGDNRRKV---LQSPDYLAHPFALTVF-EDRVF 654
Cdd:cd05819   85 GNFLASFGGSGDGdgefnGPRGIAVDS-SGNIYVADTGNHRIQKFDPDGEFLTTFgsgGSGPGQFNGPTGVAVDsDGNIY 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 528491728 655 WTDGENEAI--YGAN----KFTGSDVTLLASnLNEPQDIIV 689
Cdd:cd05819  164 VADTGNHRIqvFDPDgnflTTFGSTGTGPGQ-FNYPTGIAV 203
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 392-422 1.12e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.12e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 528491728 392 DVNECLNPGICS--QICINLKGGYKCECHNGYQ 422
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 479-570 1.78e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 44.12  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528491728 479 IFWADLGQKAIFstVLDKQDESHKKVIDDV----QMPVGIAVDwIYKNIYWSDLGSKSITVANFNGTKKKVLFNSGL-KE 553
Cdd:cd14962   25 IYVADTGRGAVF--VFDLPNGKVFVIGNAGpnrfVSPIGVAID-ANGNLYVSDAELGKVFVFDRDGKFLRAIGAGALfKR 101

                         90
                 ....*....|....*..
gi 528491728 554 PASIAVDPLSGFLYWSD 570
Cdd:cd14962  102 PTGIAVDPAGKRLYVVD 118
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 511-652 2.06e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 43.82  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528491728 511 PVGIAVDWiyKNIYWSDLGSKSITVANFNGTKKKVLFNSGLKE-----PASIAVDPlSGFLYWSDWGEpAKIEKSGMNGN 585
Cdd:cd14963   12 PMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGPGTGPgefkyPYGIAVDS-DGNIYVADLYN-GRIQVFDPDGK 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528491728 586 DRQVLVETD----IQWPNGITLDliKGRLYWVDSKLHMLCSVDLNGdnrRKVL------QSPDYLAHPFALTVFEDR 652
Cdd:cd14963   88 FLKYFPEKKdrvkLISPAGLAID--DGKLYVSDVKKHKVIVFDLEG---KLLLefgkpgSEPGELSYPNGIAVDEDG 159
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 509-660 2.58e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 43.85  E-value: 2.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528491728 509 QMPVGIAVDwIYKNIYWSDLGSKSITVANFNGTKKKVL-----FNSGLKEPASIAVDPlSGFLYWSDWGePAKIEKSGMN 583
Cdd:cd05819  102 NGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTG-NHRIQVFDPD 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528491728 584 GN-----DRQVLVETDIQWPNGITLDLiKGRLYWVDSKLHMLCSVDLNGDNRR---KVLQSPDYLAHPFALTVFED-RVF 654
Cdd:cd05819  179 GNflttfGSTGTGPGQFNYPTGIAVDS-DGNIYVADSGNNRVQVFDPDGAGFGgngNFLGSDGQFNRPSGLAVDSDgNLY 257


                 ....*.
gi 528491728 655 WTDGEN 660
Cdd:cd05819  258 VADTGN 263
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 397-430 7.07e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.61  E-value: 7.07e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 528491728  397 LNPGICSQICINLKGGYKCECHNGYQMDPTTGVC 430
Cdd:pfam14670   3 VNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 708-745 7.50e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.61  E-value: 7.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 528491728  708 NGGCSFMCLPAPQinkhspKYTCVCPEGQTLASDGLRC 745
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 479-518 2.05e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 36.75  E-value: 2.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 528491728  479 IFWADLGQKA-IFSTVLDKQDEsHKKVIDDVQMPVGIAVDW 518
Cdd:pfam00058   3 LYWTDSSLRAsISSADLNGSDR-KTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 457-495 8.87e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 34.88  E-value: 8.87e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528491728   457 YTQIVEQLRNTVALDADFIQQMIFWADLGQKAIFSTVLD 495
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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